| Year |
Citation |
Score |
| 2020 |
Kwon J, Helfman DM, Kim MY. AKT drives sustained motility following MEK inhibition via promoting SNAIL and AXL in MDA-MB-231 LM2. Biochemical and Biophysical Research Communications. PMID 32456793 DOI: 10.1016/j.bbrc.2020.05.043 |
0.516 |
|
| 2019 |
Park H-, Helfman DM. Up-regulated fibronectin in 3D culture facilitates spreading of triple negative breast cancer cells on 2D through integrin β-5 and Src. Scientific Reports. 9: 19950. PMID 31882647 DOI: 10.1038/s41598-019-56276-3 |
0.317 |
|
| 2017 |
Shin H, Kim D, Helfman DM. Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells. Oncotarget. 8: 95192-95205. PMID 29221121 DOI: 10.18632/oncotarget.19182 |
0.434 |
|
| 2017 |
Shin H, Kim D, Helfman DM. Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells. Oncotarget. PMID 28732351 DOI: 10.18632/oncotarget.19182 |
0.434 |
|
| 2017 |
Jeong S, Lim S, Schevzov G, Gunning PW, Helfman DM. Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling. Oncotarget. PMID 28431393 DOI: 10.18632/oncotarget.16825 |
0.388 |
|
| 2016 |
Choi C, Kwon J, Lim S, Helfman DM. Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer. Oncotarget. PMID 27563827 DOI: 10.18632/oncotarget.11525 |
0.478 |
|
| 2016 |
Kim DY, Helfman DM. Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. Oncogene. PMID 26876209 DOI: 10.1038/onc.2015.508 |
0.461 |
|
| 2013 |
Choi C, Helfman DM. The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2. Oncogene. 33: 3668-76. PMID 23995792 DOI: 10.1038/onc.2013.341 |
0.477 |
|
| 2011 |
Helfman DM, Pawlak G. Erratum: “Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras”. D.M. Helfman, G. Pawlak. Journal of Cellular Biochemistry. 112: 3489-3489. DOI: 10.1002/jcb.23260 |
0.304 |
|
| 2010 |
Jiang X, Lu X, McNamara G, Liu X, Cubedo E, Sarosiek KA, Sánchez-García I, Helfman DM, Lossos IS. HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway. Blood. 116: 5217-27. PMID 20844236 DOI: 10.1182/Blood-2010-04-281568 |
0.349 |
|
| 2010 |
Flynn PG, Helfman DM. Non-muscle myosin IIB helps mediate TNF cell death signaling independent of actomyosin contractility (AMC). Journal of Cellular Biochemistry. 110: 1365-75. PMID 20564232 DOI: 10.1002/jcb.22653 |
0.404 |
|
| 2009 |
Larrea MD, Hong F, Wander SA, da Silva TG, Helfman D, Lannigan D, Smith JA, Slingerland JM. RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proceedings of the National Academy of Sciences of the United States of America. 106: 9268-73. PMID 19470470 DOI: 10.1073/Pnas.0805057106 |
0.41 |
|
| 2009 |
Jiang X, Lu X, Mcnamara G, Liu X, Sarosiek KA, Helfman DM, Lossos IS. HGAL, a Lymphoma Prognostic Biomarker, Regulates Lymphocyte and Lymphoma Cell Motility by Modulation of RhoA Signaling Pathway. Blood. 114: 316-316. DOI: 10.1182/Blood.V114.22.316.316 |
0.49 |
|
| 2008 |
Helfman DM, Flynn P, Khan P, Saeed A. Tropomyosin as a regulator of cancer cell transformation. Advances in Experimental Medicine and Biology. 644: 124-31. PMID 19209818 |
0.412 |
|
| 2007 |
Lu X, Chen J, Malumbres R, Cubedo Gil E, Helfman DM, Lossos IS. HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. Blood. 110: 4268-77. PMID 17823310 DOI: 10.1182/blood-2007-04-087775 |
0.379 |
|
| 2006 |
Chen J, Ding F, Helfman DM, Lossos IS. HGAL - A Germinal Center-Like Diffuse Large B-Cell Lymphoma Prognostic Biomarker Interacts with the Cytoskeleton and Influences Cell Migration. Blood. 108: 2022-2022. DOI: 10.1182/BLOOD.V108.11.2022.2022 |
0.385 |
|
| 2005 |
Helfman DM, Pawlak G. Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras. Journal of Cellular Biochemistry. 95: 1069-80. PMID 15962288 DOI: 10.1002/jcb.20498 |
0.538 |
|
| 2004 |
Bakin AV, Safina A, Rinehart C, Daroqui C, Darbary H, Helfman DM. A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells. Molecular Biology of the Cell. 15: 4682-94. PMID 15317845 DOI: 10.1091/Mbc.E04-04-0353 |
0.35 |
|
| 2004 |
Dhawan J, Helfman DM. Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation. Journal of Cell Science. 117: 3735-48. PMID 15252113 DOI: 10.1242/jcs.01197 |
0.543 |
|
| 2004 |
Pawlak G, McGarvey TW, Nguyen TB, Tomaszewski JE, Puthiyaveettil R, Malkowicz SB, Helfman DM. Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder. International Journal of Cancer. Journal International Du Cancer. 110: 368-73. PMID 15095301 DOI: 10.1002/ijc.20151 |
0.369 |
|
| 2004 |
Lee S, Helfman DM. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. The Journal of Biological Chemistry. 279: 1885-91. PMID 14559914 DOI: 10.1074/Jbc.M306968200 |
0.583 |
|
| 2002 |
Pawlak G, Helfman DM. MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. The Journal of Biological Chemistry. 277: 26927-33. PMID 12011049 DOI: 10.1074/jbc.M202261200 |
0.514 |
|
| 2002 |
Pawlak G, Helfman DM. Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Molecular Biology of the Cell. 13: 336-47. PMID 11809843 DOI: 10.1091/mbc.01-02-0302 |
0.555 |
|
| 2001 |
Pawlak G, Helfman DM. Cytoskeletal changes in cell transformation and tumorigenesis Current Opinion in Genetics and Development. 11: 41-47. PMID 11163149 DOI: 10.1016/S0959-437X(00)00154-4 |
0.416 |
|
| 1999 |
Helfman DM, Levy ET, Berthier C, Shtutman M, Riveline D, Grosheva I, Lachish-Zalait A, Elbaum M, Bershadsky AD. Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. Molecular Biology of the Cell. 10: 3097-112. PMID 10512853 DOI: 10.1091/Mbc.10.10.3097 |
0.438 |
|
| 1998 |
Temm-Grove CJ, Jockusch BM, Weinberger RP, Schevzov G, Helfman DM. Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesions. Cell Motility and the Cytoskeleton. 40: 393-407. PMID 9712268 DOI: 10.1002/(SICI)1097-0169(1998)40:4<393::AID-CM7>3.0.CO;2-C |
0.388 |
|
| 1996 |
Gimona M, Kazzaz JA, Helfman DM. Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proceedings of the National Academy of Sciences of the United States of America. 93: 9618-23. PMID 8790379 DOI: 10.1073/PNAS.93.18.9618 |
0.444 |
|
| 1994 |
Cáceres JF, Stamm S, Helfman DM, Krainer AR. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (New York, N.Y.). 265: 1706-9. PMID 8085156 DOI: 10.1126/Science.8085156 |
0.365 |
|
| 1985 |
Lin JJ, Helfman DM, Hughes SH, Chou CS. Tropomyosin isoforms in chicken embryo fibroblasts: purification, characterization, and changes in Rous sarcoma virus-transformed cells. The Journal of Cell Biology. 100: 692-703. PMID 2982883 DOI: 10.1083/Jcb.100.3.692 |
0.394 |
|
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