| Year |
Citation |
Score |
| 2024 |
Khan I, Amin MA, Eklund EA, Gartel AL. Regulation of HOX gene expression in AML. Blood Cancer Journal. 14: 42. PMID 38453907 DOI: 10.1038/s41408-024-01004-y |
0.449 |
|
| 2023 |
Chen H, Bai Y, Kobayashi M, Xiao S, Barajas S, Cai W, Chen S, Miao J, Nguele Meke F, Yao C, Yang Y, Strube K, Satchivi O, Sun J, Ronnstrand L, ... ... Eklund EA, et al. PRL2 phosphatase promotes oncogenic KIT signaling in leukemia cells through modulating CBL phosphorylation. Molecular Cancer Research : McR. PMID 37756563 DOI: 10.1158/1541-7786.MCR-23-0115 |
0.397 |
|
| 2023 |
Williams O, Hu L, Huang W, Patel P, Bartom ET, Bei L, Hjort E, Hijiya C, Eklund EA. Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis. The Journal of Biological Chemistry. 299: 104867. PMID 37247756 DOI: 10.1016/j.jbc.2023.104867 |
0.385 |
|
| 2022 |
Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Nguele Meke F, Vemula S, Ropa J, Croop J, Boswell HS, Wan J, Jia Y, ... ... Eklund EA, et al. PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood. PMID 36206490 DOI: 10.1182/blood.2022016580 |
0.4 |
|
| 2021 |
Suarez M, Blyth GT, Mina AA, Kosciuczuk EM, Dolniak B, Dinner S, Altman JK, Eklund EA, Saleiro D, Beauchamp EM, Platanias LC. Inhibitory effects of Tomivosertib in acute myeloid leukemia. Oncotarget. 12: 955-966. PMID 34012509 DOI: 10.18632/oncotarget.27952 |
0.346 |
|
| 2020 |
Khan I, Eklund EA, Gartel AL. Therapeutic vulnerabilities of transcription factors in AML. Molecular Cancer Therapeutics. PMID 33158995 DOI: 10.1158/1535-7163.MCT-20-0115 |
0.424 |
|
| 2020 |
Wang H, Shah CA, Hu L, Huang W, Platanias LC, Eklund EA. An aberrantly sustained emergency granulopoiesis response accelerates post chemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice. The Journal of Biological Chemistry. PMID 32467231 DOI: 10.1074/Jbc.Ra120.013206 |
0.521 |
|
| 2020 |
Huang W, Liu B, Eklund EA. Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia. Leukemia. PMID 32080344 DOI: 10.1038/S41375-020-0771-7 |
0.474 |
|
| 2019 |
Kosciuczuk EM, Kar AK, Blyth GT, Fischietti M, Abedin S, Mina AA, Siliezar R, Rzymski T, Brzozka K, Eklund EA, Beauchamp EM, Eckerdt F, Saleiro D, Platanias LC. Inhibitory effects of SEL201 in acute myeloid leukemia. Oncotarget. 10: 7112-7121. PMID 31903169 DOI: 10.18632/Oncotarget.27388 |
0.513 |
|
| 2018 |
Beauchamp EM, Abedin SM, Radecki SG, Fischietti M, Arslan AD, Blyth GT, Yang A, Lantz C, Nelson A, Goo YA, Akpan I, Eklund EA, Frankfurt O, Fish EN, Thomas PM, et al. Identification and targeting of novel CDK9 complexes in acute myeloid leukemia. Blood. PMID 30587525 DOI: 10.1182/Blood-2018-08-870089 |
0.493 |
|
| 2018 |
Suraneni PK, Corey SJ, Hession MJ, Ishaq R, Awomolo A, Hasan S, Shah C, Liu H, Wickrema A, Debili N, Crispino JD, Eklund EA, Chen Y. Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity. Blood Advances. 2: 3540-3552. PMID 30538113 DOI: 10.1182/Bloodadvances.2018021923 |
0.42 |
|
| 2018 |
Huang W, Bei L, Eklund EA. Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin. Oncotarget. 9: 25891-25902. PMID 29899829 DOI: 10.18632/Oncotarget.25401 |
0.436 |
|
| 2018 |
Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA. The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia. Oncogene. PMID 29459712 DOI: 10.1038/S41388-018-0131-5 |
0.548 |
|
| 2018 |
Hu L, Huang W, Bei L, Broglie L, Eklund EA. TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 29427417 DOI: 10.4049/Jimmunol.1700931 |
0.413 |
|
| 2018 |
Shah CA, Broglie L, Hu L, Bei L, Huang W, Dressler DB, Eklund EA. Stat3 and CCAAT enhancer-binding protein β (C/ebpβ) activate Fanconi C gene transcription during emergency granulopoiesis. The Journal of Biological Chemistry. PMID 29382715 DOI: 10.1074/Jbc.Ra117.000528 |
0.458 |
|
| 2018 |
Chae H, Murphy LC, Donato M, Lee AG, Sweet-Cordero EA, Abidi P, Bittencourt H, Lacayo NJ, Dahl GVH, Aftandilian C, Davis KL, Huang M, Sumarsono N, Redell M, Fu CH, ... ... Eklund EA, et al. Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells Blood. 132: 4246-4246. DOI: 10.1182/Blood-2018-99-119974 |
0.454 |
|
| 2018 |
Suraneni PK, Corey SJ, Hession M, Ishaq R, Awomolo A, Hasan S, Debili N, Crispino JD, Eklund EA, Chen Y. Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration Blood. 132: 2429-2429. DOI: 10.1182/Blood-2018-99-118782 |
0.434 |
|
| 2017 |
Huang W, Bei L, Hjort EE, Eklund EA. Decreased calpain activity in chronic myeloid leukemia impairs apoptosis by increasing survivin in myeloid progenitors and xiap1 in differentiating granulocytes. Oncotarget. 8: 50629-50641. PMID 28881589 DOI: 10.18632/Oncotarget.16884 |
0.495 |
|
| 2017 |
Huang W, Bei L, Hjort EE, Eklund EA. Decreased Calpain activity in chronic myeloid leukemia impairs apoptosis by increasing Survivin in myeloid progenitors and xiap1 in differentiating granulocytes. Oncotarget. PMID 28431398 DOI: 10.18632/oncotarget.16884 |
0.399 |
|
| 2017 |
Kroczynska B, Blyth GT, Rafidi RL, Majchrzak-Kita B, Xu L, Saleiro D, Kosciuczuk EM, Jemielity J, Su B, Altman JK, Eklund EA, Fish EH, Platanias LC. Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses. The Journal of Biological Chemistry. PMID 28174303 DOI: 10.1074/Jbc.M116.757666 |
0.498 |
|
| 2016 |
Hjort EE, Huang W, Hu L, Eklund EA. Bcr-abl regulates Stat5 through Shp2, the interferon consensus sequence binding protein (Icsbp/Irf8), growth arrest specific 2 (Gas2) and calpain. Oncotarget. PMID 27769062 DOI: 10.18632/Oncotarget.12749 |
0.609 |
|
| 2016 |
Shah CA, Bei L, Wang H, Altman JK, Platanias LC, Eklund EA. Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells. Oncotarget. PMID 27340869 DOI: 10.18632/Oncotarget.10189 |
0.591 |
|
| 2016 |
Huang W, Luan CH, Hjort EE, Bei L, Mishra R, Sakamoto KM, Platanias LC, Eklund EA. The role of Fas-associated phosphatase 1 in leukemia stem cell-persistence during tyrosine kinase inhibitor-treatment of chronic myeloid leukemia. Leukemia. PMID 26984787 DOI: 10.1038/Leu.2016.66 |
0.453 |
|
| 2016 |
Konieczna IM, DeLuca TA, Eklund EA, Miller WM. Hoxa10 null animals exhibit reduced platelet biogenesis. British Journal of Haematology. 173: 303-13. PMID 26847476 DOI: 10.1111/Bjh.13949 |
0.714 |
|
| 2016 |
Mitton B, Hsu K, Dutta R, Tiu BC, Cox N, McLure KG, Chae HD, Smith M, Eklund EA, Solow-Cordero DE, Sakamoto KM. Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters. Oncotarget. PMID 26840025 DOI: 10.18632/Oncotarget.7085 |
0.394 |
|
| 2016 |
Konieczna IM, Deluca TA, Eklund EA, Miller WM. Hoxa10 null animals exhibit reduced platelet biogenesis British Journal of Haematology. DOI: 10.1111/bjh.13949 |
0.638 |
|
| 2015 |
Hu L, Huang W, Hjort EE, Bei L, Platanias LC, Eklund EA. The Interferon Consensus Sequence Binding Protein (Icsbp/Irf8) is Required for Termination of Emergency Granulopoiesis. The Journal of Biological Chemistry. PMID 26683374 DOI: 10.1074/Jbc.M115.681361 |
0.553 |
|
| 2015 |
Wang H, Bei L, Shah CA, Hu L, Eklund EA. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. Journal of Immunology (Baltimore, Md. : 1950). 194: 5375-87. PMID 25895533 DOI: 10.4049/Jimmunol.1401909 |
0.557 |
|
| 2015 |
Sakamoto KM, Grant S, Saleiro D, Crispino JD, Hijiya N, Giles F, Platanias L, Eklund EA. Targeting novel signaling pathways for resistant acute myeloid leukemia. Molecular Genetics and Metabolism. 114: 397-402. PMID 25533111 DOI: 10.1016/J.Ymgme.2014.11.017 |
0.392 |
|
| 2014 |
Kroczynska B, Mehrotra S, Majchrzak-Kita B, Arslan AD, Altman JK, Stein BL, McMahon B, Kozlowski P, Kahle PJ, Eklund EA, Fish EN, Platanias LC. Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses. Proceedings of the National Academy of Sciences of the United States of America. 111: 11377-82. PMID 25049393 DOI: 10.1073/Pnas.1405250111 |
0.44 |
|
| 2014 |
Altman JK, Szilard A, Goussetis DJ, Sassano A, Colamonici M, Gounaris E, Frankfurt O, Giles FJ, Eklund EA, Beauchamp EM, Platanias LC. Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2400-9. PMID 24610825 DOI: 10.1158/1078-0432.Ccr-13-3218 |
0.4 |
|
| 2014 |
Wu EJ, Goussetis DJ, Beauchamp E, Kosciuczuk EM, Altman JK, Eklund EA, Platanias LC. Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors. Cancer Biology & Therapy. 15: 473-8. PMID 24496081 DOI: 10.4161/Cbt.27824 |
0.429 |
|
| 2014 |
Bei L, Shah C, Wang H, Eklund E. Constitutive Activation of Shp2 Cooperates with MLL1 Fusion Proteins to Increase Expression of the Homeodomain Transcription Factors Cdx4, HoxA9 and HoxA10 Blood. 124: 3537-3537. DOI: 10.1182/Blood.V124.21.3537.3537 |
0.614 |
|
| 2014 |
Bei L, Shah C, Wang H, Huang W, Platanias LC, Eklund EA. Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis Oncogenesis. 3. DOI: 10.1038/oncsis.2014.49 |
0.555 |
|
| 2013 |
Shah CA, Bei L, Wang H, Platanias LC, Eklund EA. The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells. The Journal of Biological Chemistry. 288: 32490-505. PMID 24089521 DOI: 10.1074/Jbc.M113.496109 |
0.537 |
|
| 2013 |
Hu L, Huang W, Hjort E, Eklund EA. Increased Fanconi C expression contributes to the emergency granulopoiesis response. The Journal of Clinical Investigation. 123: 3952-66. PMID 23925293 DOI: 10.1172/Jci69032 |
0.495 |
|
| 2013 |
Mehrotra S, Sharma B, Joshi S, Kroczynska B, Majchrzak B, Stein BL, McMahon B, Altman JK, Licht JD, Baker DP, Eklund EA, Wickrema A, Verma A, Fish EN, Platanias LC. Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors. The Journal of Biological Chemistry. 288: 23814-22. PMID 23814052 DOI: 10.1074/Jbc.M113.476192 |
0.44 |
|
| 2013 |
Huang W, Bei L, Eklund EA. Fas-associated phosphatase 1 (Fap1) influences βcatenin activity in myeloid progenitor cells expressing the Bcr-abl oncogene. The Journal of Biological Chemistry. 288: 12766-76. PMID 23519466 DOI: 10.1074/Jbc.M112.429696 |
0.519 |
|
| 2013 |
Konieczna IM, Panuganti S, DeLuca TA, Papoutsakis ET, Eklund EA, Miller WM. Administration of nicotinamide does not increase platelet levels in mice. Blood Cells, Molecules & Diseases. 50: 171-6. PMID 23265740 DOI: 10.1016/J.Bcmd.2012.11.007 |
0.69 |
|
| 2013 |
Huang W, Bei L, Eklund EA. Fas-associated phosphatase 1 mediates Fas resistance in myeloid progenitor cells expressing the Bcr-abl oncogene. Leukemia & Lymphoma. 54: 619-30. PMID 22891763 DOI: 10.3109/10428194.2012.720979 |
0.52 |
|
| 2013 |
Shah C, Wang H, Bei L, Eklund E. Increased Expression Of Fgf2 Induces Cytokine Hypersensitivity In Leukemia Stem Cells With Translocations Involving The MLL Gene Blood. 122: 3791-3791. DOI: 10.1182/Blood.V122.21.3791.3791 |
0.585 |
|
| 2012 |
Bei L, Shah C, Wang H, Huang W, Roy R, Eklund EA. β-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells. The Journal of Biological Chemistry. 287: 39589-601. PMID 23038246 DOI: 10.1074/Jbc.M112.402172 |
0.476 |
|
| 2012 |
Kroczynska B, Sharma B, Eklund EA, Fish EN, Platanias LC. Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Molecular and Cellular Biology. 32: 2809-22. PMID 22586265 DOI: 10.1128/Mcb.00310-12 |
0.448 |
|
| 2012 |
Shah CA, Bei L, Wang H, Platanias LC, Eklund EA. HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells. The Journal of Biological Chemistry. 287: 18230-48. PMID 22493287 DOI: 10.1074/Jbc.M111.328401 |
0.563 |
|
| 2012 |
Huang W, Hu L, Bei L, Hjort E, Eklund EA. The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp). The Journal of Biological Chemistry. 287: 8110-25. PMID 22262849 DOI: 10.1074/Jbc.M111.294884 |
0.586 |
|
| 2012 |
Eklund E. The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis. Critical Reviews in Oncogenesis. 16: 65-76. PMID 22150308 DOI: 10.1615/Critrevoncog.V16.I1-2.70 |
0.518 |
|
| 2012 |
Eklund EA. Regulation of Myelopoiesis by Differentiation Stage-Specific Activities of HOXA9 and HOXA10 Blood. 120: SCI-29-SCI-29. DOI: 10.1182/Blood.V120.21.Sci-29.Sci-29 |
0.585 |
|
| 2012 |
Hjort E, Huang W, Eklund EA. Bcr-Abl Represses IRF8 Gene Transcription in a Stat5-Dependent Manner Blood. 120: 3497-3497. DOI: 10.1182/Blood.V120.21.3497.3497 |
0.634 |
|
| 2012 |
Huang W, Bei L, Eklund EA. Fap1 Controls Beta-Catenin Activity in a Gsk3-Beta Dependent Manner in Chronic Myeloid Leukemia. Blood. 120: 2404-2404. DOI: 10.1182/Blood.V120.21.2404.2404 |
0.355 |
|
| 2011 |
Eklund EA, Platanias LC. Inhibition of histone deacetylase 6 as a therapeutic strategy for acute lymphocytic leukemia. Leukemia & Lymphoma. 52: 1421-2. PMID 21657957 DOI: 10.3109/10428194.2011.577259 |
0.336 |
|
| 2011 |
Bei L, Huang W, Wang H, Shah C, Horvath E, Eklund E. HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells. The Journal of Biological Chemistry. 286: 19047-64. PMID 21471217 DOI: 10.1074/Jbc.M110.213983 |
0.604 |
|
| 2011 |
Wang H, Bei L, Shah CA, Horvath E, Eklund EA. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1. The Journal of Biological Chemistry. 286: 16832-45. PMID 21454682 DOI: 10.1074/Jbc.M110.213975 |
0.623 |
|
| 2011 |
Shah CA, Wang H, Bei L, Platanias LC, Eklund EA. HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells. The Journal of Biological Chemistry. 286: 3161-76. PMID 21087928 DOI: 10.1074/Jbc.M110.183251 |
0.593 |
|
| 2011 |
Kroczynska B, Joshi S, Eklund EA, Verma A, Kotenko SV, Fish EN, Platanias LC. Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling. The Journal of Biological Chemistry. 286: 1147-56. PMID 21075852 DOI: 10.1074/Jbc.M110.183566 |
0.486 |
|
| 2011 |
Huang W, Eklund EA. Icsbp/Irf8 Cooperates with Tel to Regulate Fas Induced Apoptosis in Myeloid Leukemia. Blood. 118: 395-395. DOI: 10.1182/Blood.V118.21.395.395 |
0.565 |
|
| 2010 |
Shinnick KM, Eklund EA, McGarry TJ. Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice Journal of Clinical Investigation. 120: 4303-4315. PMID 21041951 DOI: 10.1172/Jci43556 |
0.451 |
|
| 2010 |
Huang W, Zhou W, Saberwal G, Konieczna I, Horvath E, Katsoulidis E, Platanias LC, Eklund EA. Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. Molecular and Cellular Biology. 30: 4575-94. PMID 20679491 DOI: 10.1128/Mcb.01595-09 |
0.753 |
|
| 2010 |
Eklund EA. Genomic analysis of acute myeloid leukemia: potential for new prognostic indicators. Current Opinion in Hematology. 17: 75-8. PMID 20075726 DOI: 10.1097/Moh.0B013E3283366C43 |
0.336 |
|
| 2010 |
Shah C, Wang H, Eklund EA. HoxA10 Regulates Myeloid Progenitor Proliferation by Activating Transcription of the Gene Encoding Transforming Growth Factor Beta 2. Blood. 116: 1572-1572. DOI: 10.1182/Blood.V116.21.1572.1572 |
0.641 |
|
| 2010 |
Huang W, Eklund E. SS5-4 Constitutive activation of Shp2 blocks IFNγ-stimulated increase in Fas-sensitivity in monocytes and granulocytes Cytokine. 52: 44-45. DOI: 10.1016/J.Cyto.2010.07.187 |
0.324 |
|
| 2009 |
Saberwal G, Horvath E, Hu L, Zhu C, Hjort E, Eklund EA. The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation. The Journal of Biological Chemistry. 284: 33242-54. PMID 19801548 DOI: 10.1074/Jbc.M109.010231 |
0.601 |
|
| 2009 |
Katsoulidis E, Carayol N, Woodard J, Konieczna I, Majchrzak-Kita B, Jordan A, Sassano A, Eklund EA, Fish EN, Platanias LC. Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses. The Journal of Biological Chemistry. 284: 25051-64. PMID 19592487 DOI: 10.1074/Jbc.M109.030445 |
0.742 |
|
| 2009 |
Wang H, Lindsey S, Konieczna I, Bei L, Horvath E, Huang W, Saberwal G, Eklund EA. Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia. The Journal of Biological Chemistry. 284: 2549-67. PMID 19022774 DOI: 10.1074/Jbc.M804704200 |
0.832 |
|
| 2009 |
Huang W, Horvath E, Eklund EA. Bcr/Abl Increases Bcatenin Protein and Activity in An ICSBP-Dependent Manner in Myeloid Cells. Blood. 114: 2958-2958. DOI: 10.1182/Blood.V114.22.2958.2958 |
0.583 |
|
| 2009 |
Shinnick KM, Barry KA, Eklund EA, McGarry TJ. Geminin Regulates Hematopoietic Stem Cell Proliferation and Differentiation. Blood. 114: 1478-1478. DOI: 10.1182/Blood.V114.22.1478.1478 |
0.479 |
|
| 2008 |
Kaur S, Sassano A, Joseph AM, Majchrzak-Kita B, Eklund EA, Verma A, Brachmann SM, Fish EN, Platanias LC. Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. Journal of Immunology (Baltimore, Md. : 1950). 181: 7316-23. PMID 18981154 DOI: 10.4049/Jimmunol.181.10.7316 |
0.438 |
|
| 2008 |
Konieczna I, Horvath E, Wang H, Lindsey S, Saberwal G, Bei L, Huang W, Platanias L, Eklund EA. Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. The Journal of Clinical Investigation. 118: 853-67. PMID 18246201 DOI: 10.1172/Jci33742 |
0.805 |
|
| 2008 |
Huang W, Zhu C, Wang H, Horvath E, Eklund EA. The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells. The Journal of Biological Chemistry. 283: 7921-35. PMID 18195016 DOI: 10.1074/Jbc.M706710200 |
0.601 |
|
| 2008 |
Zhu C, Lindsey S, Konieczna I, Eklund EA. Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation. Journal of Leukocyte Biology. 83: 680-91. PMID 18089853 DOI: 10.1189/Jlb.0807514 |
0.803 |
|
| 2008 |
Eklund EA. The Role of Hox Proteins and Interferon Regulatory Factors in Myeloid Differentiation. Blood. 112: sci-34-sci-34. DOI: 10.1182/Blood.V112.11.Sci-34.Sci-34 |
0.594 |
|
| 2008 |
Wang H, Lindsey S, Konieczna I, Horvath E, Bei L, Huang W, Eklund EA. Constitutive Activation of SHP2 Protein Tyrosine Phosphatase Cooperates with HoxA10 Overexpression for Progression to Acute Myeloid Leukemia in a Murine Model Blood. 112: 752-752. DOI: 10.1182/Blood.V112.11.752.752 |
0.819 |
|
| 2008 |
Kaur S, Sassano A, Joseph AM, Majchrzak-Kita B, Eklund EA, Fish EN, Verma A, Brachmann SM, Platanias LC. 1 Dual regulatory roles of the phosphatidylinositol 3-kinase in interferon signaling Cytokine. 43: 237. DOI: 10.1016/J.Cyto.2008.07.041 |
0.319 |
|
| 2007 |
Bei L, Lu Y, Bellis SL, Zhou W, Horvath E, Eklund EA. Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation. The Journal of Biological Chemistry. 282: 16846-59. PMID 17439948 DOI: 10.1074/Jbc.M609744200 |
0.533 |
|
| 2007 |
Wang H, Lu Y, Huang W, Papoutsakis ET, Fuhrken P, Eklund EA. HoxA10 activates transcription of the gene encoding mitogen-activated protein kinase phosphatase 2 (Mkp2) in myeloid cells. The Journal of Biological Chemistry. 282: 16164-76. PMID 17430893 DOI: 10.1074/Jbc.M610556200 |
0.64 |
|
| 2007 |
Eklund EA. The role of HOX genes in malignant myeloid disease. Current Opinion in Hematology. 14: 85-9. PMID 17255784 DOI: 10.1097/Moh.0B013E32801684B6 |
0.468 |
|
| 2007 |
Huang W, Horvath E, Eklund EA. PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells. The Journal of Biological Chemistry. 282: 6629-43. PMID 17200120 DOI: 10.1074/Jbc.M607760200 |
0.504 |
|
| 2007 |
Lindsey S, Huang W, Wang H, Horvath E, Zhu C, Eklund EA. Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX). The Journal of Biological Chemistry. 282: 2237-49. PMID 17138561 DOI: 10.1074/Jbc.M608642200 |
0.796 |
|
| 2007 |
Konieczna I, Horvath E, Wang H, Platanias L, Eklund E. ICSBP Haplo-Insufficiency Synergizes with SHP2-Activation for Apoptosis Resistance and Cytokine Hypersensitivity in Myeloid Progenitors. Blood. 110: 2209-2209. DOI: 10.1182/Blood.V110.11.2209.2209 |
0.794 |
|
| 2006 |
Huang W, Saberwal G, Horvath E, Zhu C, Lindsey S, Eklund EA. Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein. Molecular and Cellular Biology. 26: 6311-32. PMID 16914719 DOI: 10.1128/Mcb.00036-06 |
0.774 |
|
| 2006 |
Eklund EA. The role of HOX genes in myeloid leukemogenesis. Current Opinion in Hematology. 13: 67-73. PMID 16456371 DOI: 10.1097/01.Moh.0000208467.63861.D6 |
0.448 |
|
| 2006 |
Lindsey S, Wang H, Eklund EA. Leukemia Associated Mutants of SHP2 Protein Tyrosine Phosphatase Prevent HoxA10 Tyrosine Phosphorylation in Differentiating Myeloid Cells, Thereby Blocking Transcription of the Gene Encoding Gp91phox. Blood. 108: 504-504. DOI: 10.1182/Blood.V108.11.504.504 |
0.803 |
|
| 2006 |
Huang W, Horvath E, Eklund EA. Leukemia Associated Mutants of SHP2 Protein Tyrosine Phosphatase Inhibit Nf1-Expression by Decreasing ICSBP and IRF2 Phosphorylation. Blood. 108: 1165-1165. DOI: 10.1182/Blood.V108.11.1165.1165 |
0.559 |
|
| 2005 |
Lindsey S, Zhu C, Lu YF, Eklund EA. HoxA10 represses transcription of the gene encoding p67phox in phagocytic cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 5269-79. PMID 16210632 DOI: 10.4049/Jimmunol.175.8.5269 |
0.76 |
|
| 2005 |
Parmar S, Smith J, Sassano A, Uddin S, Katsoulidis E, Majchrzak B, Kambhampati S, Eklund EA, Tallman MS, Fish EN, Platanias LC. Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells. Blood. 106: 2436-43. PMID 15790787 DOI: 10.1182/Blood-2004-10-4003 |
0.455 |
|
| 2005 |
Bei L, Lu Y, Eklund EA. HOXA9 activates transcription of the gene encoding gp91Phox during myeloid differentiation. The Journal of Biological Chemistry. 280: 12359-70. PMID 15681849 DOI: 10.1074/Jbc.M408138200 |
0.583 |
|
| 2005 |
Kakar R, Kautz B, Eklund EA. JAK2 is necessary and sufficient for interferon-gamma-induced transcription of the gene encoding gp91PHOX. Journal of Leukocyte Biology. 77: 120-7. PMID 15496449 DOI: 10.1189/Jlb.0704429 |
0.512 |
|
| 2005 |
Lindsey S, Lu Y, Eklund EA. HoxA10 Represses Transcription of Multiple Genes Encoding Respiratory Burst Oxidase Proteins in Undifferentiated Myeloid Cells. Blood. 106: 632-632. DOI: 10.1182/Blood.V106.11.632.632 |
0.798 |
|
| 2005 |
Huang W, Saberwal G, Zhu C, Eklund EA. ICSBP Activates Transcription of the Gene Encoding Neurofibromin 1 in Differentiating Myeloid Cells. Blood. 106: 122-122. DOI: 10.1182/Blood.V106.11.122.122 |
0.589 |
|
| 2004 |
Zhu C, Saberwal G, Lu Y, Platanias LC, Eklund EA. The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. The Journal of Biological Chemistry. 279: 50874-85. PMID 15371411 DOI: 10.1074/Jbc.M405736200 |
0.56 |
|
| 2004 |
Eklund EA, Bei L, Lu Y. HoxA9 Activates Transcription of the Gene Encoding Gp91phox, a Respiratory Burst Oxidase Protein, during Myeloid Differentiation. Blood. 104: 1470-1470. DOI: 10.1182/Blood.V104.11.1470.1470 |
0.501 |
|
| 2003 |
Lu Y, Goldenberg I, Bei L, Andrejic J, Eklund EA. HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2. The Journal of Biological Chemistry. 278: 47792-802. PMID 14512427 DOI: 10.1074/Jbc.M305885200 |
0.532 |
|
| 2002 |
Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R. SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells. The Journal of Biological Chemistry. 277: 36878-88. PMID 12145285 DOI: 10.1074/jbc.M203917200 |
0.399 |
|
| 2001 |
Miller KA, Eklund EA, Peddinghaus ML, Cao Z, Fernandes N, Turk PW, Thimmapaya B, Weitzman SA. Kruppel-like factor 4 regulates laminin alpha 3A expression in mammary epithelial cells. The Journal of Biological Chemistry. 276: 42863-8. PMID 11551969 DOI: 10.1074/Jbc.M108130200 |
0.409 |
|
| 2001 |
Kautz B, Kakar R, David E, Eklund EA. SHP1 protein-tyrosine phosphatase inhibits gp91PHOX and p67PHOX expression by inhibiting interaction of PU.1, IRF1, interferon consensus sequence-binding protein, and CREB-binding protein with homologous Cis elements in the CYBB and NCF2 genes. The Journal of Biological Chemistry. 276: 37868-78. PMID 11483597 DOI: 10.1074/Jbc.M103381200 |
0.569 |
|
| 2000 |
Eklund EA, Jalava A, Kakar R. Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines. The Journal of Biological Chemistry. 275: 20117-26. PMID 10766757 DOI: 10.1074/JBC.M907915199 |
0.399 |
|
| 1998 |
Eklund EA, Jalava A, Kakar R. PU.1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91(phox) expression. The Journal of Biological Chemistry. 273: 13957-65. PMID 9593745 DOI: 10.1074/JBC.273.22.13957 |
0.369 |
|
| 1997 |
Eklund EA, Kakar R. Identification and characterization of TF1(phox), a DNA-binding protein that increases expression of gp91(phox) in PLB985 myeloid leukemia cells. The Journal of Biological Chemistry. 272: 9344-55. PMID 9083071 DOI: 10.1074/jbc.272.14.9344 |
0.389 |
|
| 1995 |
Eklund EA, Skalnik DG. Characterization of a gp91-phox promoter element that is required for interferon γ-induced transcription Journal of Biological Chemistry. 270: 8267-8273. PMID 7713934 DOI: 10.1074/Jbc.270.14.8267 |
0.336 |
|
| 1994 |
Newburger PE, Skalnik DG, Hopkins PJ, Eklund EA, Curnutte JT. Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558 Journal of Clinical Investigation. 94: 1205-1211. PMID 8083361 DOI: 10.1172/Jci117437 |
0.303 |
|
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