| Year |
Citation |
Score |
| 2022 |
Nelczyk AT, Ma L, Gupta AD, Gamage HEV, McHenry MT, Henn MA, Kadiri M, Wang Y, Krawczynska N, Bendre S, He S, Shahoei SH, Madak-Erdogan Z, Hsiao SH, Saleh T, ... ... Spinella MJ, et al. The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166515. PMID 35932893 DOI: 10.1016/j.bbadis.2022.166515 |
0.342 |
|
| 2021 |
Singh R, Fazal Z, Bikorimana E, Boyd RI, Yerby C, Tomlin M, Baldwin H, Shokry D, Corbet AK, Shahid K, Hattab A, Freemantle SJ, Spinella MJ. Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy. Molecular Oncology. PMID 34482638 DOI: 10.1002/1878-0261.13096 |
0.322 |
|
| 2020 |
Albany C, Spinella MJ, Adra N, Hanna NH, Einhorn L. A phase I study of guadecitabine (SGI-110) plus cisplatin in patients with platinum refractory germ cell tumors. Journal of Clinical Oncology. 38: 408-408. DOI: 10.1200/Jco.2020.38.6_Suppl.408 |
0.303 |
|
| 2019 |
Tripathi SK, Pandey K, Panda M, Spinella MJ, Rengasamy KR, Biswal BK. The potential of retinoids for combination therapy of lung cancer: updates and future directions. Pharmacological Research. 104331. PMID 31254665 DOI: 10.1016/J.Phrs.2019.104331 |
0.374 |
|
| 2019 |
Singh R, Fazal Z, Corbet AK, Bikorimana E, Rodriguez JC, Khan EM, Shahid K, Freemantle SJ, Spinella MJ. Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors. Cancers. 11. PMID 31181810 DOI: 10.3390/Cancers11060796 |
0.432 |
|
| 2019 |
Singh R, Fazal Z, Bikorimana E, Corbet A, Rodriguez J, Steege A, Freemantle SJ, Spinella MJ. Abstract 5188: Epigenetic changes mediated by polycomb repressive complex 2 are associated with cisplatin acquired resistance in testicular germ cell tumor Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-5188 |
0.389 |
|
| 2018 |
Hashemi-Sadraei N, Einhorn LH, Perkins S, Spinella MJ, Fang F, Hanna NH, Nephew KP, Albany C. Safety and tolerability of guadecitabine (SGI-110) plus cisplatin in patients (pts) with platinum-refractory germ cell tumors (GCT): Preliminary results from an open label phase 1b study. Journal of Clinical Oncology. 36: e16545-e16545. DOI: 10.1200/Jco.2018.36.15_Suppl.E16545 |
0.378 |
|
| 2017 |
Chovanec M, Taza F, Kalra M, Hahn N, Nephew KP, Spinella MJ, Albany C. Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review. Targeted Oncology. PMID 29230671 DOI: 10.1007/S11523-017-0546-X |
0.341 |
|
| 2017 |
Yim CY, Bikorimana E, Khan E, Warzecha JM, Shin L, Rodriguez J, Dmitrovsky E, Freemantle SJ, Spinella MJ. G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer. Cell Cycle (Georgetown, Tex.). 1-10. PMID 28910567 DOI: 10.1080/15384101.2017.1371884 |
0.404 |
|
| 2016 |
Albany C, Hever-Jardine MP, von Herrmann KM, Yim CY, Tam J, Warzecha JM, Shin L, Bock SE, Curran BS, Chaudhry AS, Kim F, Sandusky GE, Taverna P, Freemantle SJ, Christensen BC, ... ... Spinella MJ, et al. Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine. Oncotarget. PMID 27936464 DOI: 10.18632/Oncotarget.13811 |
0.533 |
|
| 2016 |
Yim CY, Sekula D, Hever-Jardine MP, Liu X, Warzecha JM, Tam J, Freemantle SJ, Dmitrovsky E, Spinella MJ. G0S2 suppresses oncogenic transformation by repressing a Myc-regulated transcriptional program. Cancer Research. PMID 26837760 DOI: 10.1158/0008-5472.Can-15-2265 |
0.436 |
|
| 2015 |
Sonnenburg D, Spinella MJ, Albany C. Epigenetic Targeting of Platinum Resistant Testicular Cancer. Current Cancer Drug Targets. PMID 26694252 DOI: 10.2174/1568009616666151222150359 |
0.395 |
|
| 2015 |
Yim CY, Sekula DJ, Freemantle SJ, Dmitrovsky E, Spinella MJ. Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc Cancer Research. 75: 2026-2026. DOI: 10.1158/1538-7445.Am2015-2026 |
0.476 |
|
| 2014 |
Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biology & Therapy. 15: 463-72. PMID 24496080 DOI: 10.4161/Cbt.27821 |
0.552 |
|
| 2014 |
Yim CY, Mao P, Spinella MJ. Headway and hurdles in the clinical development of dietary phytochemicals for cancer therapy and prevention: lessons learned from vitamin A derivatives. The Aaps Journal. 16: 281-8. PMID 24431081 DOI: 10.1208/S12248-014-9562-2 |
0.595 |
|
| 2014 |
Mao P, Jardine MP, Rahme GJ, Yang EC, Tam J, Kodali A, Biswal B, Fadul CE, Gaur AB, Israel MA, Pletnev A, Spinella M. Abstract 4605: STK17A is a potential therapeutic target in glioblastoma Cancer Research. 74: 4605-4605. DOI: 10.1158/1538-7445.Am2014-4605 |
0.713 |
|
| 2013 |
Mao P, Hever-Jardine MP, Rahme GJ, Yang E, Tam J, Kodali A, Biswal B, Fadul CE, Gaur A, Israel MA, Spinella MJ. Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma. Plos One. 8: e81803. PMID 24312360 DOI: 10.1371/Journal.Pone.0081803 |
0.702 |
|
| 2012 |
Biswal BK, Beyrouthy MJ, Hever-Jardine MP, Armstrong D, Tomlinson CR, Christensen BC, Marsit CJ, Spinella MJ. Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. Plos One. 7: e53003. PMID 23300844 DOI: 10.1371/Journal.Pone.0053003 |
0.515 |
|
| 2012 |
Mao P, Jardine M, Niemaszyk L, Haghkerdar J, Yang E, yanco EG, Desai D, Beyrouthy M, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ. Abstract 2958: The novel protein kinase STK17A is a direct p53 target gene that mediates response to genotoxic and nutritional stress in a cancer cell context-dependent manner Cancer Research. 72: 2958-2958. DOI: 10.1158/1538-7445.Am2012-2958 |
0.785 |
|
| 2011 |
Poliandri AH, Gamsby JJ, Christian M, Spinella MJ, Loros JJ, Dunlap JC, Parker MG. Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). Journal of Biological Rhythms. 26: 187-99. PMID 21628546 DOI: 10.1177/0748730411401579 |
0.378 |
|
| 2011 |
Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ. Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. The Journal of Biological Chemistry. 286: 19381-91. PMID 21489989 DOI: 10.1074/Jbc.M111.218040 |
0.787 |
|
| 2010 |
Beyrouthy MJ, Garner K, Hever MP, Freemantle SJ, Eastman A, Dmitrovsky E, Spinella MJ. Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells Cancer Research. 70: 4273-4273. DOI: 10.1158/1538-7445.Am10-4273 |
0.515 |
|
| 2009 |
Beyrouthy MJ, Garner KM, Hever MP, Freemantle SJ, Eastman A, Dmitrovsky E, Spinella MJ. High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. Cancer Research. 69: 9360-6. PMID 19951990 DOI: 10.1158/0008-5472.Can-09-1490 |
0.506 |
|
| 2009 |
Snow GE, Kasper AC, Busch AM, Schwarz E, Ewings KE, Bee T, Spinella MJ, Dmitrovsky E, Freemantle SJ. Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. Bmc Cancer. 9: 383. PMID 19874621 DOI: 10.1186/1471-2407-9-383 |
0.448 |
|
| 2009 |
Heim KC, Gamsby JJ, Hever MP, Freemantle SJ, Loros JJ, Dunlap JC, Spinella MJ. Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140. Plos One. 4: e7639. PMID 19862326 DOI: 10.1371/Journal.Pone.0007639 |
0.755 |
|
| 2007 |
Heim KC, White KA, Deng D, Tomlinson CR, Moore JH, Freemantle SJ, Spinella MJ. Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. Molecular Cancer. 6: 57. PMID 17880687 DOI: 10.1186/1476-4598-6-57 |
0.798 |
|
| 2007 |
Kerley-Hamilton JS, Pike AM, Hutchinson JA, Freemantle SJ, Spinella MJ. The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins. Biochimica Et Biophysica Acta. 1769: 209-19. PMID 17397945 DOI: 10.1016/J.Bbaexp.2007.02.002 |
0.795 |
|
| 2007 |
Li H, Cherukuri P, Li N, Cowling V, Spinella M, Cole M, Godwin AK, Wells W, DiRenzo J. Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. Cancer Research. 67: 501-10. PMID 17234757 DOI: 10.1158/0008-5472.Can-05-4571 |
0.421 |
|
| 2007 |
Freemantle SJ, Vaseva AV, Ewings KE, Bee T, Krizan KA, Kelley MR, Hattab EM, Memoli VA, Black CC, Spinella MJ, Dmitrovsky E. Repression of cyclin D1 as a target for germ cell tumors. International Journal of Oncology. 30: 333-40. PMID 17203214 DOI: 10.3892/Ijo.30.2.333 |
0.459 |
|
| 2006 |
Giuliano CJ, Freemantle SJ, Spinella MJ. Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells. Current Cancer Therapy Reviews. 2: 255-270. PMID 24482633 DOI: 10.2174/157339406777934681 |
0.424 |
|
| 2005 |
Giuliano CJ, Kerley-Hamilton JS, Bee T, Freemantle SJ, Manickaratnam R, Dmitrovsky E, Spinella MJ. Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochimica Et Biophysica Acta. 1731: 48-56. PMID 16168501 DOI: 10.1016/J.Bbaexp.2005.08.006 |
0.8 |
|
| 2005 |
Kerley-Hamilton JS, Pike AM, Li N, DiRenzo J, Spinella MJ. A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma. Oncogene. 24: 6090-100. PMID 15940259 DOI: 10.1038/Sj.Onc.1208755 |
0.815 |
|
| 2005 |
Curtin JC, Spinella MJ. p53 in human embryonal carcinoma: identification of a transferable, transcriptional repression domain in the N-terminal region of p53. Oncogene. 24: 1481-90. PMID 15674351 DOI: 10.1038/Sj.Onc.1208130 |
0.779 |
|
| 2005 |
White KA, Yore MM, Deng D, Spinella MJ. Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid. The Journal of Biological Chemistry. 280: 7829-35. PMID 15632153 DOI: 10.1074/Jbc.M412707200 |
0.448 |
|
| 2003 |
Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene. 22: 7305-15. PMID 14576840 DOI: 10.1038/Sj.Onc.1206936 |
0.435 |
|
| 2003 |
White KA, Yore MM, Warburton SL, Vaseva AV, Rieder E, Freemantle SJ, Spinella MJ. Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. The Journal of Biological Chemistry. 278: 43889-92. PMID 14506269 DOI: 10.1074/Jbc.C300374200 |
0.493 |
|
| 2003 |
Spinella MJ, Kerley JS, White KA, Curtin JC. Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model. The Journal of Nutrition. 133: 273S-276S. PMID 12514308 DOI: 10.1093/Jn/133.1.273S |
0.783 |
|
| 2002 |
Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ, Dmitrovsky E. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. Gene. 291: 17-27. PMID 12095675 DOI: 10.1016/S0378-1119(02)00594-2 |
0.504 |
|
| 2002 |
Freemantle SJ, Kerley JS, Olsen SL, Gross RH, Spinella MJ. Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma Oncogene. 21: 2880-2889. PMID 11973648 DOI: 10.1038/Sj.Onc.1205408 |
0.532 |
|
| 2001 |
Dragnev KH, Freemantle SJ, Spinella MJ, Dmitrovsky E. Cyclin proteolysis as a retinoid cancer prevention mechanism. Annals of the New York Academy of Sciences. 952: 13-22. PMID 11795432 DOI: 10.1111/J.1749-6632.2001.Tb02724.X |
0.483 |
|
| 2001 |
Kerley JS, Olsen SL, Freemantle SJ, Spinella MJ. Transcriptional activation of the nuclear receptor corepressor RIP140 by retinoic acid: A potential negative-feedback regulatory mechanism Biochemical and Biophysical Research Communications. 285: 969-975. PMID 11467847 DOI: 10.1006/Bbrc.2001.5274 |
0.496 |
|
| 2001 |
Curtin JC, Dragnev KH, Sekula D, Christie AJ, Dmitrovsky E, Spinella MJ. Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function. Oncogene. 20: 2559-69. PMID 11420666 DOI: 10.1038/Sj.Onc.1204370 |
0.789 |
|
| 1999 |
Kitareewan S, Spinella MJ, Allopenna J, Reczek PR, Dmitrovsky E. 4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARgamma independent pathway. Oncogene. 18: 5747-55. PMID 10523855 DOI: 10.1038/Sj.Onc.1202981 |
0.492 |
|
| 1999 |
Hromas R, Ye H, Spinella M, Dmitrovsky E, Xu D, Costa RH. Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model. Cell and Tissue Research. 297: 371-82. PMID 10460485 DOI: 10.1007/S004410051365 |
0.513 |
|
| 1999 |
Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ, Dmitrovsky E. Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. The Journal of Biological Chemistry. 274: 22013-8. PMID 10419526 DOI: 10.1074/Jbc.274.31.22013 |
0.469 |
|
| 1998 |
Maerz WJ, Baselga J, Reuter VE, Mellado B, Myers ML, Bosl GJ, Spinella MJ, Dmitrovsky E. FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas Oncogene. 17: 761-767. PMID 9715278 DOI: 10.1038/Sj.Onc.1201992 |
0.511 |
|
| 1998 |
Spinella MJ, Kitareewan S, Mellado B, Sekula D, Khoo KS, Dmitrovsky E. Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells. Oncogene. 16: 3471-80. PMID 9692555 DOI: 10.1038/Sj.Onc.1201876 |
0.483 |
|
| 1997 |
Brigle KE, Spinella MJ, Sierra EE, Goldman ID. Organization of the murine reduced folate carrier gene and identification of variant splice forms. Biochimica Et Biophysica Acta. 1353: 191-8. PMID 9294013 DOI: 10.1016/S0167-4781(97)00082-1 |
0.343 |
|
| 1997 |
Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM. Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. Journal of Molecular Endocrinology. 18: 167-76. PMID 9134503 DOI: 10.1677/Jme.0.0180167 |
0.466 |
|
| 1997 |
Sierra EE, Brigle KE, Spinella MJ, Goldman ID. pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH. Biochemical Pharmacology. 53: 223-31. PMID 9037255 DOI: 10.1016/S0006-2952(96)00730-7 |
0.319 |
|
| 1996 |
Spinella MJ, Brigle KE, Freemantle SJ, Sierra EE, Goldman ID. Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects. Biochemical Pharmacology. 52: 703-12. PMID 8765468 DOI: 10.1016/0006-2952(96)00347-4 |
0.398 |
|
| 1996 |
Spinella MJ, Brigle KE, GoldmanD. Molecular cloning of murine folylpoly-gamma-glutamate synthetase. Biochimica Et Biophysica Acta. 1305: 11-4. PMID 8605241 DOI: 10.1016/0167-4781(95)00193-X |
0.389 |
|
| 1995 |
Spinella MJ, Brigle KE, Sierra EE, Goldman ID. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. The Journal of Biological Chemistry. 270: 7842-9. PMID 7713875 DOI: 10.1074/Jbc.270.14.7842 |
0.373 |
|
| 1995 |
Kranz DM, Patrick TA, Brigle KE, Spinella MJ, Roy EJ. Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis. Proceedings of the National Academy of Sciences of the United States of America. 92: 9057-61. PMID 7568072 DOI: 10.1073/Pnas.92.20.9057 |
0.381 |
|
| 1995 |
Brigle KE, Spinella MJ, Sierra EE, Goldman ID. Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. The Journal of Biological Chemistry. 270: 22974-9. PMID 7559435 DOI: 10.1074/Jbc.270.39.22974 |
0.367 |
|
| 1995 |
Sierra EE, Brigle KE, Spinella MJ, Goldman ID. Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells. Biochemical Pharmacology. 50: 1287-94. PMID 7488246 DOI: 10.1016/0006-2952(95)94097-Y |
0.391 |
|
| 1994 |
Brigle KE, Spinella MJ, Westin EH, Goldman ID. Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells Biochemical Pharmacology. 47: 337-345. PMID 8304978 DOI: 10.1016/0006-2952(94)90025-6 |
0.349 |
|
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