| Year |
Citation |
Score |
| 2024 |
Li J, Hilimire TA, Yueying L, Wang L, Liang J, Győrffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, ... ... Chen M, et al. Mediator kinase inhibition reverses castration resistance of advanced prostate cancer. The Journal of Clinical Investigation. PMID 38546787 DOI: 10.1172/JCI176709 |
0.379 |
|
| 2023 |
Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, et al. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Nucleic Acids Research. PMID 37378433 DOI: 10.1093/nar/gkad538 |
0.344 |
|
| 2021 |
Hu L, Wu H, Jiang T, Kuang M, Liu B, Guo X, He D, Chen M, Gu J, Gu J, Chang L, Feng M, Ruan Y. pVHL promotes lysosomal degradation of YAP in lung adenocarcinoma. Cellular Signalling. 110002. PMID 33823241 DOI: 10.1016/j.cellsig.2021.110002 |
0.303 |
|
| 2019 |
Chen M, Li J, Liang J, Thompson ZS, Kathrein K, Broude EV, Roninson IB. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition. Cells. 8. PMID 31717492 DOI: 10.3390/Cells8111413 |
0.371 |
|
| 2019 |
Li J, Ji H, Porter DC, Broude EV, Roninson IB, Chen M. Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay. Cells. 8. PMID 31590445 DOI: 10.3390/Cells8101208 |
0.418 |
|
| 2019 |
Roninson IB, Győrffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV. Identifying Cancers Impacted by CDK8/19. Cells. 8. PMID 31382571 DOI: 10.3390/Cells8080821 |
0.43 |
|
| 2019 |
Liang J, Chen M, Broude EV, Roninson IB. Role of transcription-regulating kinase CDK8 in colon cancer metastasis. Oncotarget. 10: 622-623. PMID 30774756 DOI: 10.18632/Oncotarget.26593 |
0.414 |
|
| 2018 |
Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. Cancer Research. PMID 30185549 DOI: 10.1158/0008-5472.Can-18-1583 |
0.438 |
|
| 2017 |
Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, et al. CDK8/19 Mediator kinases potentiate induction of transcription by NFκB. Proceedings of the National Academy of Sciences of the United States of America. PMID 28855340 DOI: 10.1073/Pnas.1710467114 |
0.454 |
|
| 2017 |
Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M. Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Scientific Reports. 7: 43023. PMID 28223711 DOI: 10.1038/Srep43023 |
0.393 |
|
| 2017 |
McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. PMID 28147342 DOI: 10.18632/Oncotarget.14894 |
0.417 |
|
| 2017 |
Nouri M, Caradec J, Lubik AA, Li N, Hollier BG, Takhar M, Altimirano-Dimas M, Chen M, Roshan-Moniri M, Butler M, Lehman M, Bishop J, Truong S, Huang SC, Cochrane D, et al. Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance. Oncotarget. PMID 28145883 DOI: 10.18632/Oncotarget.14850 |
0.422 |
|
| 2017 |
McDermott, Chumanevich A, Liang J, Chen M, Altilia S, Hennes C, Roninson I, Broude E. Abstract P3-07-05: CDK8 inhibition improves the efficacy of ER- and HER2-targeted drugs in breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P3-07-05 |
0.371 |
|
| 2017 |
Liang J, Chen M, Karthikeyan M, Pena MM, Hughes D, Kaza V, Lim C, Broude E, Roninson IB. Abstract 4896: Role of CDK8 in colon cancer hepatic metastasis Cancer Research. 77: 4896-4896. DOI: 10.1158/1538-7445.Am2017-4896 |
0.405 |
|
| 2017 |
Chen M, Hu B, Ji H, Altilia S, Liang J, McDermott M, Lim C, Porter DC, Broude E, Roninson I. Abstract 1512: Functional characterization of novel transcription-regulating cancer drug targets, CDK8 and CDK19, using CRISPR/Cas9 knockout and a highly selective CDK8/19 kinase inhibitor Cancer Research. 77: 1512-1512. DOI: 10.1158/1538-7445.Am2017-1512 |
0.466 |
|
| 2016 |
McDermott M, Györffy B, Chumanevich A, Kaza V, Porter D, Catroppo J, Chen M, Oliver D, Shtutman M, Roninson I, Broude E. Abstract P5-04-07: CDK8 protein complex as a potential biomarker and therapeutic target in breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P5-04-07 |
0.424 |
|
| 2015 |
Broude EV, Gyorffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB. Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. Current Cancer Drug Targets. 15: 739-49. PMID 26452386 DOI: 10.2174/156800961508151001105814 |
0.413 |
|
| 2015 |
Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M. Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. Oncotarget. 6: 13088-104. PMID 26036626 DOI: 10.18632/Oncotarget.3743 |
0.399 |
|
| 2015 |
McDermott MS, Lim C, Chen M, Chumanevich A, Catroppo JF, Gyorffy B, Oliver D, Roninson IB, Broude EV. Abstract P4-15-13: CDK8 inhibition potentiates anti-ER and anti-HER2 therapies in breast cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P4-15-13 |
0.397 |
|
| 2015 |
Porter DC, Chen M, Liang J, Kaza V, Chumanevich A, Altilia S, Farmaki E, Pena M, Schools GP, Chatzistamou I, Friedhoff LT, Wentland MP, Broude EV, Kiaris H, Roninson IB. Abstract PR08: Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19 Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-Pr08 |
0.387 |
|
| 2014 |
Li N, Chen M, Truong S, Yan C, Buttyan R. Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors. The Prostate. 74: 1400-10. PMID 25132524 DOI: 10.1002/Pros.22855 |
0.436 |
|
| 2014 |
Chen M, Kaza V, Liang J, McDermott M, Roninson I. Abstract 616: Transcription-regulating kinases CDK8 and CDK19 as novel therapeutic targets for advanced prostate cancer Cancer Research. 74: 616-616. DOI: 10.1158/1538-7445.Am2014-616 |
0.538 |
|
| 2014 |
Li N, Buttyan R, Truong S, Yu Y, Chen M. Abstract 5574: Gli2 protein and the AR operational switch to the castration resistant prostate cancer transcription program Cancer Research. 74: 5574-5574. DOI: 10.1158/1538-7445.Am2014-5574 |
0.498 |
|
| 2014 |
Chen M, McDermott M, Yang Z, Liang J, Schools GP, Lim C, Lu T, George SR, West DK, Porter DC, Broude EV, Roninson IB. Abstract 4883: CDK8: A new druggable mediator of NFκB activity Cancer Research. 74: 4883-4883. DOI: 10.1158/1538-7445.Am2014-4883 |
0.467 |
|
| 2014 |
Porter DC, Liang J, Kaza V, Chumanevich AA, Altilia S, Farmaki E, Chen M, Schools GP, Chatzistamou I, Pena MM, Friedhoff LT, Wentland MP, Broude E, Kiaris H, Roninson IB. Abstract 4879: Targeting the seed and the soil of cancers with selective small-molecule inhibitors of CDK8/19: Chemopotentiating, chemopreventive, anti-invasive and anti-metastatic activities Cancer Research. 74: 4879-4879. DOI: 10.1158/1538-7445.Am2014-4879 |
0.408 |
|
| 2014 |
McDermott M, Gyorffy B, Lim C, Chumanevich A, Yang Z, Chen M, Catroppo JF, Roninson I, Broude EV. Abstract 2101: Role of CDK8 in estrogen receptor signaling in breast cancers Cancer Research. 74: 2101-2101. DOI: 10.1158/1538-7445.Am2014-2101 |
0.436 |
|
| 2013 |
Li N, Chen M, Buttyan R. Abstract 1294: Identification of the binding domains that allow ligand-independent co-activation of androgen receptor by Gli2. Cancer Research. 73: 1294-1294. DOI: 10.1158/1538-7445.Am2013-1294 |
0.429 |
|
| 2013 |
Li N, Chen M, Buttyan R. 502 IDENTIFICATION OF THE BINDING DOMAINS THAT ENABLE THE LIGAND-INDEPENDENT CO-ACTIVATION OF ANDROGEN RECEPTOR BY GLI2 Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.1896 |
0.314 |
|
| 2012 |
Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, et al. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proceedings of the National Academy of Sciences of the United States of America. 109: 13799-804. PMID 22869755 DOI: 10.1073/Pnas.1206906109 |
0.429 |
|
| 2012 |
Wang H, Jiang M, Cui H, Chen M, Buttyan R, Hayward SW, Hai T, Wang Z, Yan C. The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Molecular and Cellular Biology. 32: 3190-202. PMID 22665497 DOI: 10.1128/Mcb.00159-12 |
0.477 |
|
| 2012 |
Levina E, Chen M, Carkner R, Shtutman M, Buttyan R. Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner. The Prostate. 72: 817-24. PMID 22025366 DOI: 10.1002/Pros.21500 |
0.505 |
|
| 2011 |
Chen M, Carkner R, Buttyan R. The hedgehog/Gli signaling paradigm in prostate cancer. Expert Review of Endocrinology & Metabolism. 6: 453-467. PMID 21776292 DOI: 10.1586/Eem.11.24 |
0.468 |
|
| 2011 |
Tanner MJ, Welliver RC, Chen M, Shtutman M, Godoy A, Smith G, Mian BM, Buttyan R. Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblasts and paracrine signaling to prostate cancer cells. Plos One. 6: e16027. PMID 21267466 DOI: 10.1371/Journal.Pone.0016027 |
0.475 |
|
| 2011 |
Chen M, Akinola O, Carkner R, Mian B, Buttyan R. 406 High-Throughput Screen For Genes That Selectively Promote Growth Of Androgen Independent Prostate Cancer Cells The Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.495 |
0.492 |
|
| 2011 |
Welliver C, Tanner M, Chen M, Mian B, Godoy A, Smith G, Buttyan R. 1578 Regulation Of Prostate Stromal Cell Gene Expression By The Androgen Receptor And Its Effects On Paracrine Signaling To Prostate Cancer Cells The Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.1614 |
0.475 |
|
| 2010 |
Mechlin CW, Tanner MJ, Chen M, Buttyan R, Levin RM, Mian BM. Gli2 expression and human bladder transitional carcinoma cell invasiveness. The Journal of Urology. 184: 344-51. PMID 20488474 DOI: 10.1016/J.Juro.2010.03.007 |
0.415 |
|
| 2010 |
Chen M, Feuerstein MA, Levina E, Baghel PS, Carkner RD, Tanner MJ, Shtutman M, Vacherot F, Terry S, de la Taille A, Buttyan R. Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells. Molecular Cancer. 9: 89. PMID 20420697 DOI: 10.1186/1476-4598-9-89 |
0.436 |
|
| 2010 |
Fu YY, Gao WL, Chen M, Chai KX, Wang YL, Chen LM. Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway. Human Reproduction (Oxford, England). 25: 623-32. PMID 20089521 DOI: 10.1093/Humrep/Dep457 |
0.677 |
|
| 2010 |
Chen M, Chen LM, Lin CY, Chai KX. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. Molecular and Cellular Biochemistry. 337: 259-66. PMID 19911255 DOI: 10.1007/S11010-009-0307-Y |
0.666 |
|
| 2010 |
Tanner M, Chen M, Levina E, Carkner R, Buttyan R. 1408 Induction Of Secreted Wnt Factor Wisp1/Ccn4 By Human Prostate Stromal Cells By Microenviornmental Hypoxia The Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.1100 |
0.398 |
|
| 2009 |
Chen M, Tanner M, Levine AC, Levina E, Ohouo P, Buttyan R. Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells. Cell Cycle (Georgetown, Tex.). 8: 149-57. PMID 19158486 DOI: 10.4161/Cc.8.1.7532 |
0.51 |
|
| 2009 |
Chen M, Tanner M, Levine AC, Levina E, Buttyan R. Androgen Regulates The Expression Of Critical Hedgehog Signaling Components In Prostate Cancer Cells The Journal of Urology. 181: 96-96. DOI: 10.1016/S0022-5347(09)60273-1 |
0.465 |
|
| 2008 |
Chen M, Buttyan R. Editorial comment on: Hedgehog signalling in androgen independent prostate cancer. European Urology. 54: 1341-3. PMID 18262714 DOI: 10.1016/J.Eururo.2008.01.071 |
0.386 |
|
| 2008 |
Chen M, Chen LM, Lin CY, Chai KX. The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells. Biochimica Et Biophysica Acta. 1783: 896-903. PMID 18054338 DOI: 10.1016/J.Bbamcr.2007.10.019 |
0.701 |
|
| 2007 |
Chen M, Fu YY, Lin CY, Chen LM, Chai KX. Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3. Biochimica Et Biophysica Acta. 1773: 1133-40. PMID 17532063 DOI: 10.1016/J.Bbamcr.2007.04.013 |
0.7 |
|
| 2006 |
Chen M, Chen LM, Chai KX. Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression. Biochemical and Biophysical Research Communications. 346: 1245-53. PMID 16806080 DOI: 10.1016/J.Bbrc.2006.06.049 |
0.655 |
|
| 2006 |
Chen LM, Wang C, Chen M, Marcello MR, Chao J, Chao L, Chai KX. Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation. American Journal of Physiology. Renal Physiology. 291: F567-77. PMID 16638913 DOI: 10.1152/Ajprenal.00047.2006 |
0.629 |
|
| 2006 |
Chen M, Chen LM, Chai KX. Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. The Prostate. 66: 911-20. PMID 16541421 DOI: 10.1002/Pros.20325 |
0.685 |
|
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