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Ashwani K Thakur - Publications

Affiliations: 
Biological Science and Bioengineering Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India 
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kumar V, Sinha N, Thakur AK. Necessity of regulatory guidelines for the development of amyloid based biomaterials. Biomaterials Science. PMID 34018497 DOI: 10.1039/d1bm00059d  0.351
2020 Burra G, Maina MB, Serpell LC, Thakur AK. Nucleation-dependent aggregation kinetics of Yeast Sup35 fragment GNNQQNY. Journal of Molecular Biology. 166732. PMID 33279578 DOI: 10.1016/j.jmb.2020.166732  0.369
2020 Bajpai A, Ahmad QT, Tang HW, Manzar N, Singh V, Thakur A, Ateeq B, Perrimon N, Sinha P. A model of oral peptide therapeutics for adult Intestinal Stem Cell tumors. Disease Models & Mechanisms. PMID 32540914 DOI: 10.1242/Dmm.044420  0.336
2019 Singh V, Patel KA, Sharma RK, Patil PR, Joshi AS, Parihar R, Athilingam T, Sinha N, Ganesh S, Sinha P, Roy I, Thakur AK. Discovery of arginine ethyl ester as polyglutamine aggregation inhibitor: Conformational transitioning of huntingtin N-terminus augments aggregation suppression. Acs Chemical Neuroscience. PMID 31460743 DOI: 10.1021/Acschemneuro.9B00167  0.44
2019 Burra G, Thakur AK. Insights into the molecular mechanism behind solubilization of amyloidogenic polyglutamine‐containing peptides Biopolymers. 111. DOI: 10.1002/Pep2.24094  0.381
2018 Joshi AS, Singh V, Gahane AY, Thakur AK. Biodegradable nanoparticles containing mechanism based peptide inhibitors reduce polyglutamine aggregation in cell models and alleviate motor symptoms in Drosophila model of Huntington's disease. Acs Chemical Neuroscience. PMID 30452227 DOI: 10.1021/Acschemneuro.8B00545  0.379
2018 Saha I, Singh V, Burra G, Thakur AK. Osmolytes modulate polyglutamine aggregation in a sequence dependent manner. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3115. PMID 30062707 DOI: 10.1002/Psc.3115  0.457
2018 Singh V, Krishna Deepak RNV, Sengupta B, Joshi AS, Fan H, Sen P, Thakur AK. Calmidazolium chloride and its complex with serum albumin prevent Huntingtin exon1 aggregation. Molecular Pharmaceutics. PMID 29979597 DOI: 10.1021/Acs.Molpharmaceut.8B00380  0.419
2017 Singh V, Sharma RK, Athilingam T, Sinha P, Sinha N, Thakur AK. NMR spectroscopy-based metabolomics of Drosophila model of Huntington's disease suggests altered cell energetics. Journal of Proteome Research. PMID 28871787 DOI: 10.1021/Acs.Jproteome.7B00491  0.338
2017 Burra G, Thakur AK. Inhibition of polyglutamine aggregation by SIMILAR huntingtin N-terminal sequences: Prospective molecules for preclinical evaluation in Huntington's disease. Biopolymers. PMID 28406522 DOI: 10.1002/Bip.23021  0.462
2016 Burra G, Thakur AK. Unaided trifluoroacetic acid pretreatment solubilizes polyglutamine peptides and retains their biophysical properties of aggregation. Analytical Biochemistry. 494: 23-30. PMID 26514067 DOI: 10.1016/J.Ab.2015.10.006  0.456
2015 Burra G, Thakur AK. Anhydrous trifluoroacetic acid pretreatment converts insoluble polyglutamine peptides to soluble monomers. Data in Brief. 5: 1066-71. PMID 26793752 DOI: 10.1016/J.Dib.2015.11.007  0.319
2015 Singh V, Snigdha K, Singh C, Sinha N, Thakur AK. Understanding the self-assembly of Fmoc-phenylalanine to hydrogel formation. Soft Matter. 11: 5353-64. PMID 26059479 DOI: 10.1039/C5Sm00843C  0.306
2015 Mishra R, Thakur AK. Amyloid nanospheres from polyglutamine rich peptides: assemblage through an intermolecular salt bridge interaction. Organic & Biomolecular Chemistry. 13: 4155-9. PMID 25692827 DOI: 10.1039/C4Ob02589J  0.397
2014 Joshi AS, Thakur AK. Biodegradable delivery system containing a peptide inhibitor of polyglutamine aggregation: a step toward therapeutic development in Huntington's disease. Journal of Peptide Science : An Official Publication of the European Peptide Society. 20: 630-9. PMID 24788406 DOI: 10.1002/Psc.2640  0.466
2014 Singh V, Rai RK, Arora A, Sinha N, Thakur AK. Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria. Scientific Reports. 4: 3875. PMID 24464217 DOI: 10.1038/Srep03875  0.334
2013 Tomar R, Garg DK, Mishra R, Thakur AK, Kundu B. N-terminal domain of Pyrococcus furiosus l-asparaginase functions as a non-specific, stable, molecular chaperone. The Febs Journal. 280: 2688-99. PMID 23551356 DOI: 10.1111/Febs.12271  0.422
2012 Jayaraman M, Mishra R, Kodali R, Thakur AK, Koharudin LMI, Gronenborn AM, Wetzel R. Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties Biochemistry. 51: 2706-2716. PMID 22432740 DOI: 10.1021/Bi3000929  0.462
2012 Mishra R, Jayaraman M, Roland BP, Landrum E, Fullam T, Kodali R, Thakur AK, Arduini I, Wetzel R. Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates. Journal of Molecular Biology. 415: 900-17. PMID 22178478 DOI: 10.1016/J.Jmb.2011.12.011  0.472
2012 Jayaraman M, Kodali R, Sahoo B, Thakur AK, Mayasundari A, Mishra R, Peterson CB, Wetzel R. Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments. Journal of Molecular Biology. 415: 881-99. PMID 22178474 DOI: 10.1016/J.Jmb.2011.12.010  0.488
2011 Jayaraman M, Thakur AK, Kar K, Kodali R, Wetzel R. Assays for studying nucleated aggregation of polyglutamine proteins. Methods (San Diego, Calif.). 53: 246-54. PMID 21232603 DOI: 10.1016/J.Ymeth.2011.01.001  0.424
2009 Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IJ, Anjum DH, Kodali R, Creamer TP, Conway JF, Gronenborn AM, Wetzel R. Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism. Nature Structural & Molecular Biology. 16: 380-9. PMID 19270701 DOI: 10.1038/Nsmb.1570  0.501
2007 Ignatova Z, Thakur AK, Wetzel R, Gierasch LM. In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence. The Journal of Biological Chemistry. 282: 36736-43. PMID 17942400 DOI: 10.1074/Jbc.M703682200  0.445
2006 O'Nuallain B, Thakur AK, Williams AD, Bhattacharyya AM, Chen S, Thiagarajan G, Wetzel R. Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay. Methods in Enzymology. 413: 34-74. PMID 17046390 DOI: 10.1016/S0076-6879(06)13003-7  0.462
2006 Thakur AK, Kishore R. Characterization of β-turn and Asx-turns mimicry in a model peptide: Stabilization via CH · · · O interaction Biopolymers. 81: 440-449. PMID 16411188 DOI: 10.1002/Bip.20441  0.372
2006 Bhattacharyya A, Thakur AK, Chellgren VM, Thiagarajan G, Williams AD, Chellgren BW, Creamer TP, Wetzel R. Oligoproline effects on polyglutamine conformation and aggregation. Journal of Molecular Biology. 355: 524-35. PMID 16321399 DOI: 10.1016/J.Jmb.2005.10.053  0.404
2005 Bhattacharyya AM, Thakur AK, Wetzel R. polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction. Proceedings of the National Academy of Sciences of the United States of America. 102: 15400-5. PMID 16230628 DOI: 10.1073/Pnas.0501651102  0.452
2004 Thakur AK, Yang W, Wetzel R. Inhibition of polyglutamine aggregate cytotoxicity by a structure-based elongation inhibitor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 923-5. PMID 15001566 DOI: 10.1096/Fj.03-1238Fje  0.493
2002 Thakur AK, Wetzel R. Mutational analysis of the structural organization of polyglutamine aggregates. Proceedings of the National Academy of Sciences of the United States of America. 99: 17014-9. PMID 12444250 DOI: 10.1073/Pnas.252523899  0.475
2001 Thakur AK, Kishore R. Influence of hydrophobic interactions on the conformational adaptability of the beta-Ala residue. Journal of Peptide Research. 57: 455-461. PMID 11437949 DOI: 10.1034/J.1399-3011.2001.00839.X  0.329
2001 Thakur AK, Kishore R. Crystallographic characterisation of novel β-turn like folds in a model peptide: stabilisation by main-chain to side-chain interactions Tetrahedron Letters. 42: 4691-4694. DOI: 10.1016/S0040-4039(01)00788-2  0.333
2000 Thakur AK, Kishore R. Stabilization of a novel β‐turn‐like motif by nonconventional intramolecular hydrogen‐bonding interactions in a model peptide incorporating β‐alanine Biopolymers. 53: 447-454. PMID 10775060 DOI: 10.1002/(Sici)1097-0282(200005)53:6<447::Aid-Bip1>3.0.Co;2-H  0.355
1999 Thakur AK, Ashish, Kishore R. Novel hydrogen bonding ring motifs in a model peptide: crystal and molecular conformation Chemical Communications. 1643-1644. DOI: 10.1039/A904711E  0.338
1998 Thakur AK, Kishore R. An observation of a folded β-Ala conformation in a model peptide: Boc-L-Pip-β-Ala-NHCH3, X-ray diffraction study Tetrahedron Letters. 39: 9553-9556. DOI: 10.1016/S0040-4039(98)02122-4  0.312
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