Year |
Citation |
Score |
2023 |
Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, Assi SA, Costanza M, Weniger MA, Akalin A, Anagnostopoulos I, Bukur T, Casarotto MG, Damm F, Daumke O, ... ... Grosschedl R, et al. Transcriptional reprogramming by mutated IRF4 in lymphoma. Nature Communications. 14: 6947. PMID 37935654 DOI: 10.1038/s41467-023-41954-8 |
0.346 |
|
2022 |
Zolotarev N, Bayer M, Grosschedl R. EBF1 is continuously required for stabilizing local chromatin accessibility in pro-B cells. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210595119. PMID 36409886 DOI: 10.1073/pnas.2210595119 |
0.386 |
|
2022 |
Bayer M, Boller S, Ramamoothy S, Zolotarev N, Cauchy P, Iwanami N, Mittler G, Boehm T, Grosschedl R. Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling. Genes & Development. 36: 901-915. PMID 36167471 DOI: 10.1101/gad.349696.122 |
0.425 |
|
2022 |
Lenaerts A, Kucinski I, Deboutte W, Derecka M, Cauchy P, Manke T, Göttgens B, Grosschedl R. EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors. The Journal of Experimental Medicine. 219. PMID 36048017 DOI: 10.1084/jem.20212437 |
0.355 |
|
2021 |
Antonio Urrutia G, Ramachandran H, Cauchy P, Boo K, Ramamoorthy S, Boller S, Dogan E, Clapes T, Trompouki E, Torres-Padilla ME, Palvimo JJ, Pichler A, Grosschedl R. ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation. Genes & Development. PMID 34244292 DOI: 10.1101/gad.345843.120 |
0.323 |
|
2020 |
Wang Y, Zolotarev N, Yang CY, Rambold A, Mittler G, Grosschedl R. A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin. Immunity. PMID 33159853 DOI: 10.1016/j.immuni.2020.10.009 |
0.375 |
|
2020 |
Kucinski I, Wilson NK, Hannah R, Kinston SJ, Cauchy P, Lenaerts A, Grosschedl R, Göttgens B. Interactions between lineage-associated transcription factors govern haematopoietic progenitor states. The Embo Journal. e104983. PMID 33103827 DOI: 10.15252/embj.2020104983 |
0.317 |
|
2020 |
Ramamoorthy S, Kometani K, Herman JS, Bayer M, Boller S, Edwards-Hicks J, Ramachandran H, Li R, Klein-Geltink R, Pearce EL, Grün D, Grosschedl R. EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes & Development. PMID 33004416 DOI: 10.1101/gad.340216.120 |
0.333 |
|
2018 |
Li R, Cauchy P, Ramamoorthy S, Boller S, Chavez L, Grosschedl R. Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming. Genes & Development. PMID 29440261 DOI: 10.1101/gad.309583.117 |
0.423 |
|
2018 |
Boller S, Li R, Grosschedl R. Defining B Cell Chromatin: Lessons from EBF1. Trends in Genetics : Tig. PMID 29336845 DOI: 10.1016/j.tig.2017.12.014 |
0.389 |
|
2017 |
Musa YR, Boller S, Puchalska M, Grosschedl R, Mittler G. Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Utilizing Data Independent Acquisition. Journal of Proteome Research. PMID 29181981 DOI: 10.1021/acs.jproteome.7b00369 |
0.39 |
|
2016 |
Yang CY, Ramamoorthy S, Boller S, Rosenbaum M, Rodriguez Gil A, Mittler G, Imai Y, Kuba K, Grosschedl R. Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis. Genes & Development. PMID 27807034 DOI: 10.1101/gad.285452.116 |
0.436 |
|
2016 |
Schnappauf O, Beyes S, Dertmann A, Freihen V, Frey P, Jägle S, Rose K, Michoel T, Grosschedl R, Hecht A. Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. Biochimica Et Biophysica Acta. PMID 27504909 DOI: 10.1016/j.bbagrm.2016.08.002 |
0.338 |
|
2014 |
Boller S, Grosschedl R. The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function. Immunological Reviews. 261: 102-15. PMID 25123279 DOI: 10.1111/imr.12206 |
0.406 |
|
2013 |
Grosschedl R. Establishment and maintenance of B cell identity. Cold Spring Harbor Symposia On Quantitative Biology. 78: 23-30. PMID 24733381 DOI: 10.1101/sqb.2013.78.020057 |
0.401 |
|
2013 |
Nechanitzky R, Akbas D, Scherer S, Györy I, Hoyler T, Ramamoorthy S, Diefenbach A, Grosschedl R. Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nature Immunology. 14: 867-75. PMID 23812095 DOI: 10.1038/ni.2641 |
0.387 |
|
2012 |
Györy I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, Grosschedl R. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes & Development. 26: 668-82. PMID 22431510 DOI: 10.1101/gad.187328.112 |
0.379 |
|
2010 |
Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R. Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner. Cell Stem Cell. 7: 496-507. PMID 20887955 DOI: 10.1016/j.stem.2010.07.015 |
0.341 |
|
2010 |
Treiber N, Treiber T, Zocher G, Grosschedl R. Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins. Genes & Development. 24: 2270-5. PMID 20876732 DOI: 10.1101/gad.1976610 |
0.331 |
|
2010 |
Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R. Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity. 32: 714-25. PMID 20451411 DOI: 10.1016/J.Immuni.2010.04.013 |
0.429 |
|
2010 |
Mandel EM, Grosschedl R. Transcription control of early B cell differentiation. Current Opinion in Immunology. 22: 161-7. PMID 20144854 DOI: 10.1016/j.coi.2010.01.010 |
0.417 |
|
2008 |
Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Fariñas I, Grosschedl R, McConnell SK. Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron. 57: 364-77. PMID 18255030 DOI: 10.1016/J.Neuron.2007.12.012 |
0.374 |
|
2008 |
Pongubala JM, Northrup DL, Lancki DW, Medina KL, Treiber T, Bertolino E, Thomas M, Grosschedl R, Allman D, Singh H. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nature Immunology. 9: 203-15. PMID 18176567 DOI: 10.1038/Ni1555 |
0.582 |
|
2007 |
Schneider R, Grosschedl R. Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes & Development. 21: 3027-43. PMID 18056419 DOI: 10.1101/Gad.1604607 |
0.366 |
|
2007 |
Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R. Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Molecular and Cellular Biology. 27: 579-94. PMID 17101802 DOI: 10.1128/Mcb.01192-06 |
0.414 |
|
2006 |
Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K, Zeidler C, Lehmann U, Eder M, Baum C, Grosschedl R, Stanulla M, Scherr M, Welte K. LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nature Medicine. 12: 1191-7. PMID 17063141 DOI: 10.1038/nm1474 |
0.331 |
|
2006 |
Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fariñas I, Karsenty G, Grosschedl R. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 125: 971-86. PMID 16751105 DOI: 10.1016/J.Cell.2006.05.012 |
0.315 |
|
2006 |
Roessler S, Grosschedl R. Role of transcription factors in commitment and differentiation of early B lymphoid cells. Seminars in Immunology. 18: 12-9. PMID 16431127 DOI: 10.1016/j.smim.2005.12.001 |
0.329 |
|
2004 |
Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes & Development. 18: 2718-23. PMID 15545629 DOI: 10.1101/gad.1249504 |
0.316 |
|
2004 |
Roth W, Sustmann C, Kieslinger M, Gilmozzi A, Irmer D, Kremmer E, Turck C, Grosschedl R. PIASy-deficient mice display modest defects in IFN and Wnt signaling Journal of Immunology. 173: 6189-6199. PMID 15528356 |
0.346 |
|
2004 |
Medina KL, Pongubala JM, Reddy KL, Lancki DW, Dekoter R, Kieslinger M, Grosschedl R, Singh H. Assembling a gene regulatory network for specification of the B cell fate. Developmental Cell. 7: 607-17. PMID 15469848 DOI: 10.1016/J.Devcel.2004.08.006 |
0.559 |
|
2003 |
Dobreva G, Dambacher J, Grosschedl R. SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Genes & Development. 17: 3048-61. PMID 14701874 DOI: 10.1101/gad.1153003 |
0.378 |
|
2003 |
Pérez-Alvarado GC, Martínez-Yamout M, Allen MM, Grosschedl R, Dyson HJ, Wright PE. Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes. Biochemistry. 42: 7348-57. PMID 12809490 DOI: 10.1021/Bi034062O |
0.314 |
|
2001 |
Sachdev S, Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes & Development. 15: 3088-103. PMID 11731474 DOI: 10.1101/Gad.944801 |
0.406 |
|
2001 |
Reya T, Okamura R, Grosschedl R. Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors. Cold Spring Harbor Symposia On Quantitative Biology. 64: 133-40. PMID 11232278 DOI: 10.1101/Sqb.1999.64.133 |
0.6 |
|
2000 |
Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, Grosschedl R. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 13: 15-24. PMID 10933391 DOI: 10.1016/S1074-7613(00)00004-2 |
0.636 |
|
2000 |
Pérez-Alvarado GC, Munnerlyn A, Dyson HJ, Grosschedl R, Wright PE. Identification of the regions involved in DNA binding by the mouse PEBP2α protein Febs Letters. 470: 125-130. PMID 10734220 DOI: 10.1016/S0014-5793(00)01296-5 |
0.397 |
|
1999 |
O'Riordan M, Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity. 11: 21-31. PMID 10435576 DOI: 10.1016/S1074-7613(00)80078-3 |
0.512 |
|
1999 |
Eastman Q, Grosschedl R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals Current Opinion in Cell Biology. 11: 233-240. PMID 10209158 DOI: 10.1016/S0955-0674(99)80031-3 |
0.377 |
|
1999 |
Galceran J, Fariñas I, Depew MJ, Clevers H, Grosschedl R. Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes & Development. 13: 709-17. PMID 10090727 DOI: 10.1101/Gad.13.6.709 |
0.38 |
|
1998 |
Hsu S, Galceran J, Grosschedl R. Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin Molecular and Cellular Biology. 18: 4807-4818. PMID 9671490 DOI: 10.1128/Mcb.18.8.4807 |
0.338 |
|
1998 |
Okamura RM, Sigvardsson M, Galceran J, Verbeek S, Clevers H, Grosschedl R. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity. 8: 11-20. PMID 9462507 DOI: 10.1016/S1074-7613(00)80454-9 |
0.466 |
|
1997 |
McKendry R, Hsu SC, Harland RM, Grosschedl R. LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. Developmental Biology. 192: 420-31. PMID 9441678 DOI: 10.1006/Dbio.1997.8797 |
0.481 |
|
1997 |
Giese K, Pagel J, Grosschedl R. Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1. Proceedings of the National Academy of Sciences of the United States of America. 94: 12845-12850. PMID 9371763 DOI: 10.1073/Pnas.94.24.12845 |
0.399 |
|
1997 |
Sigvardsson M, O'Riordan M, Grosschedl R. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity. 7: 25-36. PMID 9252117 DOI: 10.1016/S1074-7613(00)80507-5 |
0.46 |
|
1997 |
Bruhn L, Munnerlyn A, Grosschedl R. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes & Development. 11: 640-653. PMID 9119228 DOI: 10.1101/Gad.11.5.640 |
0.403 |
|
1997 |
Riese J, Yu X, Munnerlyn A, Eresh S, Hsu SC, Grosschedl R, Bienz M. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell. 88: 777-87. PMID 9118221 DOI: 10.1016/S0092-8674(00)81924-8 |
0.412 |
|
1997 |
Jenuwein T, Forrester WC, Fernández-Herrero LA, Laible G, Dull M, Grosschedl R. Extension of chromatin accessibility by nuclear matrix attachment regions Nature. 385: 269-272. PMID 9000077 DOI: 10.1038/385269A0 |
0.429 |
|
1996 |
Clevers HC, Grosschedl R. Transcriptional control of lymphoid development: lessons from gene targeting. Immunology Today. 17: 336-43. PMID 8763820 DOI: 10.1016/0167-5699(96)10019-0 |
0.438 |
|
1996 |
Kratochwil K, Dull M, Farinas I, Galceran J, Grosschedl R. Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes & Development. 10: 1382-1394. PMID 8647435 DOI: 10.1101/Gad.10.11.1382 |
0.393 |
|
1995 |
Giese K, Kingsley C, Kirshner JR, Grosschedl R. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes & Development. 9: 995-1008. PMID 7774816 DOI: 10.1101/Gad.9.8.995 |
0.355 |
|
1995 |
Grosschedl R. Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination. Current Opinion in Cell Biology. 7: 362-370. PMID 7662366 DOI: 10.1016/0955-0674(95)80091-3 |
0.395 |
|
1995 |
Lin H, Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF Nature. 376: 263-267. PMID 7542362 DOI: 10.1038/376263A0 |
0.501 |
|
1995 |
Hagman J, Gutch MJ, Lin H, Grosschedl R. EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains. The Embo Journal. 14: 2907-2916. DOI: 10.1002/J.1460-2075.1995.Tb07290.X |
0.432 |
|
1994 |
Grosschedl R, Giese K, Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures Trends in Genetics. 10: 94-100. PMID 8178371 DOI: 10.1016/0168-9525(94)90232-1 |
0.383 |
|
1994 |
Giese K, Pagel J, Grosschedl R. Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors. Proceedings of the National Academy of Sciences of the United States of America. 91: 3368-3372. PMID 8159753 DOI: 10.1073/Pnas.91.8.3368 |
0.398 |
|
1994 |
Forrester W, Genderen Cv, Jenuwein T, Grosschedl R. Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions Science. 265: 1221-1225. PMID 8066460 DOI: 10.1126/Science.8066460 |
0.458 |
|
1994 |
Hagman J, Grosschedl R. Regulation of gene expression at early stages of B-cell differentiation Current Opinion in Immunology. 6: 222-230. PMID 8011207 DOI: 10.1016/0952-7915(94)90095-7 |
0.473 |
|
1994 |
Van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R. Development of several organs that require inductive epithelial- mesenchymal interactions is impaired in LEF-1-deficient mice Genes and Development. 8: 2691-2703. PMID 7958926 DOI: 10.1101/Gad.8.22.2691 |
0.392 |
|
1993 |
Travis A, Hagman J, Hwang L, Grosschedl R. Purification of early-B-cell factor and characterization of its DNA- binding specificity Molecular and Cellular Biology. 13: 3392-3400. PMID 8497258 DOI: 10.1128/Mcb.13.6.3392 |
0.421 |
|
1993 |
Giese K, Grosschedl R. LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites. The Embo Journal. 12: 4667-4676. DOI: 10.1002/J.1460-2075.1993.Tb06155.X |
0.453 |
|
1992 |
Giese K, Cox J, Grosschedl R. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell. 69: 185-95. PMID 1555239 DOI: 10.1016/0092-8674(92)90129-Z |
0.398 |
|
1992 |
Hagman J, Grosschedl R. An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene Proceedings of the National Academy of Sciences of the United States of America. 89: 8889-8893. PMID 1409581 DOI: 10.1073/Pnas.89.19.8889 |
0.38 |
|
1992 |
Matsuuchi L, Gold MR, Travis A, Grosschedl R, DeFranco AL, Kelly RB. The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proceedings of the National Academy of Sciences of the United States of America. 89: 3404-8. PMID 1373499 DOI: 10.1073/Pnas.89.8.3404 |
0.36 |
|
1991 |
Travis A, Hagman J, Grosschedl R. Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: Analysis of the requirement for upstream factor-binding sites and initiation site sequences Molecular and Cellular Biology. 11: 5756-5766. PMID 1922076 DOI: 10.1128/Mcb.11.11.5756 |
0.467 |
|
1991 |
Travis A, Amsterdam A, Belanger C, Grosschedl R. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] Genes & Development. 5: 880-894. PMID 1827423 DOI: 10.1101/Gad.5.5.880 |
0.471 |
|
1991 |
Giese K, Amsterdam A, Grosschedl R. DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1. Genes & Development. 5: 2567-2578. PMID 1752444 DOI: 10.1101/Gad.5.12B.2567 |
0.419 |
|
1991 |
Hagman J, Travis A, Grosschedl R. A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. The Embo Journal. 10: 3409-3417. DOI: 10.1002/J.1460-2075.1991.Tb04905.X |
0.528 |
|
1988 |
Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice Cell. 55: 619-625. PMID 3180222 DOI: 10.1016/0092-8674(88)90220-6 |
0.331 |
|
1988 |
Grosschedl R, Marx M. Stable propagation of the active transcriptional state of an immunoglobulin μ gene requires continuous enhancer function Cell. 55: 645-654. PMID 3141063 DOI: 10.1016/0092-8674(88)90223-1 |
0.432 |
|
1986 |
Baltimore D, Grosschedl R, Weaver D, Costantini F, Imanishi-Kari T. Studies of immunodifferentiation using transgenic mice. Cold Spring Harbor Symposia On Quantitative Biology. 50: 417-20. PMID 3938364 DOI: 10.1101/Sqb.1985.050.01.052 |
0.408 |
|
1985 |
Grosschedl R, Whitehead DB. Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements Cell. 41: 885-897. PMID 3924411 DOI: 10.1016/S0092-8674(85)80069-6 |
0.46 |
|
1984 |
Grosschedl R, Weaver D, Baltimore D, Costantini F. Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell. 38: 647-58. PMID 6091894 DOI: 10.1016/0092-8674(84)90259-9 |
0.396 |
|
1983 |
Grosschedl R, Mächler M, Rohrer U, Birnstiel ML. A functional component of the sea urchin H2A gene modulator contains an extended sequence homology to a viral enhancer. Nucleic Acids Research. 11: 8123-36. PMID 6324073 DOI: 10.1093/Nar/11.23.8123 |
0.353 |
|
1980 |
Grosschedl R, Birnstiel ML. Identification of regulatory sequences in the prelude sequences of an H2A histone gene by study of specific deletion mutants in vivo Proceedings of the National Academy of Sciences of the United States of America. 77: 1432-1436. PMID 6929494 DOI: 10.1073/Pnas.77.3.1432 |
0.386 |
|
1979 |
Grosschedl R, Schwarz E. Nucleotide sequence of the cro - cII - oop region of bacteriophage 434 DNA Nucleic Acids Research. 6: 867-881. PMID 375198 DOI: 10.1093/Nar/6.3.867 |
0.335 |
|
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