Thomas Franklin Westbrook - Publications

Affiliations: 
2008- Biochemistry and Molecular Biology Baylor College of Medicine, Houston, TX 
Area:
cancer research, genetics, technology, therapeutics
Website:
https://profiles.viictr.org/display/BCM/thomas-westbrook

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, ... ... Westbrook TF, et al. Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. Elife. 11. PMID 36043466 DOI: 10.7554/eLife.78163  0.645
2021 Gao Y, Kabotyanski EB, Shepherd JH, Villegas E, Acosta D, Hamor C, Sun T, Montmeyor-Garcia C, He X, Dobrolecki LE, Westbrook TF, Lewis MT, Hilsenbeck SG, Zhang XH, Perou CM, et al. Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics. Cancer Research Communications. 1: 178-193. PMID 35156101 DOI: 10.1158/2767-9764.crc-21-0106  0.318
2021 Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, Yee BA, Li H, Madrigal AA, Neill NJ, Shankar A, Tyagi S, Westbrook TF, Yeo GW. Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer. Molecular Cell. PMID 34216543 DOI: 10.1016/j.molcel.2021.06.014  0.357
2020 Krug K, Jaehnig EJ, Satpathy S, Blumenberg L, Karpova A, Anurag M, Miles G, Mertins P, Geffen Y, Tang LC, Heiman DI, Cao S, Maruvka YE, Lei JT, Huang C, ... ... Westbrook TF, et al. Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy. Cell. PMID 33212010 DOI: 10.1016/j.cell.2020.10.036  0.307
2020 Arnal-Estapé A, Cai WL, Albert AE, Zhao M, Stevens LE, López-Giráldez F, Patel KD, Tyagi S, Schmitt EM, Westbrook TF, Nguyen DX. Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6. Oncogene. PMID 32157212 DOI: 10.1038/S41388-020-1246-Z  0.677
2020 Gao Y, Kabotyanski E, Acosta D, Villegas E, Westbrook TF, Perou CM, Rosen JM. Abstract P4-08-01: Tumor suppressor PLK2 may serve as a biomarker in triple negative breast cancer for combinational therapy of PLK1 inhibitors with the standard-of-care chemotherapy Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P4-08-01  0.463
2019 Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, et al. Reduction of Global H3K27me Enhances HER2/ErbB2 Targeted Therapy. Cell Reports. 29: 249-257.e8. PMID 31597089 DOI: 10.1016/J.Celrep.2019.08.105  0.391
2019 Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo HC, Toneff MJ, Nguyen T, Bu W, ... ... Westbrook TF, et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nature Cell Biology. PMID 31451770 DOI: 10.1038/S41556-019-0373-7  0.362
2018 Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, ... ... Westbrook TF, et al. Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Cell Reports. 25: 1898-1911.e5. PMID 30428356 DOI: 10.1016/J.Celrep.2018.10.061  0.333
2018 Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, ... ... Westbrook TF, et al. A druggable genome screen identifies modifiers of α-synuclein levels via a tiered cross-species validation approach. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30249792 DOI: 10.1523/Jneurosci.0254-18.2018  0.479
2018 Stylianou N, Lehman ML, Wang C, Fard AT, Rockstroh A, Fazli L, Jovanovic L, Ward M, Sadowski MC, Kashyap AS, Buttyan R, Gleave ME, Westbrook TF, Williams ED, Gunter JH, et al. A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome. Oncogene. PMID 30194451 DOI: 10.1038/S41388-018-0488-5  0.386
2018 Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. PMID 29615789 DOI: 10.1038/S41586-018-0018-1  0.419
2018 Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, ... ... Westbrook TF, et al. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nature Medicine. PMID 29578538 DOI: 10.1038/Nm.4507  0.403
2018 Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, et al. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. PMID 29576454 DOI: 10.1016/J.Cell.2018.02.037  0.602
2018 Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, ... Westbrook TF, et al. Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nature Genetics. PMID 29379199 DOI: 10.1038/S41588-018-0044-9  0.394
2017 Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, ... ... Westbrook TF, et al. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. PMID 28528867 DOI: 10.1016/J.Ccell.2017.04.013  0.411
2017 Ramabadran R, Wang J, Guzman A, Cullen SM, Brunetti L, Gundry M, Chan S, Kyba M, Westbrook T, Goodell M. Loss of De Novo DNA Methyltransferase DNMT3A Impacts Alternative Splicing in Hematopoietic Stem Cells Blood. 130: 1-1. DOI: 10.1182/Blood.V130.Suppl_1.1.1  0.36
2016 Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, et al. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. PMID 27720485 DOI: 10.1016/J.Neuron.2016.09.022  0.316
2016 Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, ... ... Westbrook TF, et al. Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nature Cell Biology. 18: 822. PMID 27350446 DOI: 10.1038/Ncb3379  0.353
2016 Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, ... ... Westbrook TF, et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nature Cell Biology. PMID 27183469 DOI: 10.1038/Ncb3355  0.429
2016 Acosta D, Villegas E, Kabotyanski E, Montemayor C, Kurley SJ, Dominguez-Vidana R, Shaw CA, Westbrook TF, Rosen JM. Abstract A05: The tumor suppressor function of Plk2 in triple-negative breast cancer may be mediated through regulation of Plk1 Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-A05  0.464
2015 Mahamdallie SS, Hanks S, Karlin KL, Zachariou A, R Perdeaux E, Ruark E, Shaw CA, Renwick A, Ramsay E, Yost S, Elliott A, Birch J, Capra M, Gray J, Hale J, ... ... Westbrook TF, et al. Mutations in the transcriptional repressor REST predispose to Wilms tumor. Nature Genetics. PMID 26551668 DOI: 10.1038/Ng.3440  0.348
2015 Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, ... ... Westbrook TF, et al. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. PMID 26331541 DOI: 10.1038/Nature14985  0.476
2015 Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Reports. 11: 1486-500. PMID 26004182 DOI: 10.1016/J.Celrep.2015.04.053  0.735
2015 He Y, Wu AC, Harrington BS, Davies CM, Wallace SJ, Adams MN, Palmer JS, Roche DK, Hollier BG, Westbrook TF, Hamidi H, Konecny GE, Winterhoff B, Chetty NP, Crandon AJ, et al. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene. PMID 25893298 DOI: 10.1038/Onc.2015.101  0.411
2015 Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L, Zhao H, Zhao Z, Du S, Tao J, Lee B, Westbrook TF, Wong ST, Jin X, Rosen JM, et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 27: 193-210. PMID 25600338 DOI: 10.1016/J.Ccell.2014.11.017  0.376
2015 Westbrook TF, Nair A, Sun T, Karlin KL, Kessler J, Migliaccio I, Nguyen DX, Bernardi RJ, Renwick A, Creighton CJ, Dephoure N, Gygi SP, Shaw CA, Gibbs R, Wheeler D, et al. Abstract P6-11-01: A broad spectrum therapeutic strategy for TNBC revealed by a new pathway that coordinates oncogenic RTKs Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-11-01  0.62
2014 Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, ... ... Westbrook TF, et al. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Reports. 9: 1318-32. PMID 25453754 DOI: 10.1016/J.Celrep.2014.10.011  0.674
2014 Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, et al. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Research : Bcr. 16: 430. PMID 25212826 DOI: 10.1186/S13058-014-0430-X  0.368
2014 Miao Q, Ku AT, Nishino Y, Howard JM, Rao AS, Shaver TM, Garcia GE, Le DN, Karlin KL, Westbrook TF, Poli V, Nguyen H. Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nature Communications. 5: 4088. PMID 24909826 DOI: 10.1038/Ncomms5088  0.301
2014 Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, ... ... Westbrook TF, et al. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. The Journal of Clinical Investigation. 124: 398-412. PMID 24316975 DOI: 10.1172/Jci71180  0.424
2013 Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, ... ... Westbrook TF, et al. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 498: 325-31. PMID 23719381 DOI: 10.1038/Nature12204  0.327
2013 Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX. Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell. 23: 725-38. PMID 23707782 DOI: 10.1016/J.Ccr.2013.04.009  0.648
2013 Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2: e00358. PMID 23682311 DOI: 10.7554/Elife.00358  0.773
2013 Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. Author response: A role for PVRL4-driven cell–cell interactions in tumorigenesis Elife. DOI: 10.7554/Elife.00358.038  0.705
2013 Cheung WKC, Zhao M, Liu Z, Cao PD, Stevens LE, Westbrook TF, Nguyen DX. Abstract 3872: A lineage-selective transcriptional pathway linking lung differentiation and cancer metastasis. Cancer Research. 73: 3872-3872. DOI: 10.1158/1538-7445.Am2013-3872  0.405
2012 Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. Plos One. 7: e30207. PMID 22879872 DOI: 10.1371/Journal.Pone.0030207  0.414
2012 Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, et al. An animal model of MYC-driven medulloblastoma. Cancer Cell. 21: 155-67. PMID 22340590 DOI: 10.1016/J.Ccr.2011.12.021  0.376
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Westbrook TF, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/Science.1212728  0.713
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Westbrook TF, et al. Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Cancer Research. 72: 3091-3091. DOI: 10.1158/1538-7445.Am2012-3091  0.711
2012 Fu X, Kumar V, Shea M, Biswal N, Nanda S, Chayanam S, Mitchell T, Hergenroeder G, Meerbrey K, Joshi A, Westbrook T, Mills G, Creighton C, Hilsenbeck S, Osborne C, et al. Abstract PD01-01: Overcoming endocrine therapy resistance related to PTEN loss by strategic combinations with mTOR, AKT, or MEK inhibitors Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-Pd01-01  0.385
2011 Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, ... ... Westbrook TF, et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 144: 703-18. PMID 21376233 DOI: 10.1016/J.Cell.2011.02.003  0.767
2011 Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, ... ... Westbrook TF, et al. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 3665-70. PMID 21307310 DOI: 10.1073/Pnas.1019736108  0.759
2011 Westbrook TF. Abstract SY01-04: Tackling breast cancer: from genetic screens to new therapeutic strategies Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy01-04  0.484
2011 Fu X, Shea M, Biswal N, Mitchell T, Giuliano M, Healy N, Meerbrey K, Joshi A, Westbrook T, Hilsenbeck S, Osborne C, Schiff R. P4-01-03: Establishment and Characterization of an Endocrine Resistance Model In Vitro and In Vivo by Inducible PTEN Knockdown. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P4-01-03  0.407
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/J.Cell.2009.05.006  0.739
2008 Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. CDYL Bridges REST and Histone Methyltransferases for Gene Repression and Suppression of Cellular Transformation Molecular Cell. 32: 718-726. PMID 19061646 DOI: 10.1016/J.Molcel.2008.10.025  0.758
2008 Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation Nature. 452: 370-374. PMID 18354483 DOI: 10.1038/Nature06780  0.751
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/Science.1149200  0.784
2005 Westbrook TF, Stegmeier F, Elledge SJ. Dissecting cancer pathways and vulnerabilities with RNAi Cold Spring Harbor Symposia On Quantitative Biology. 70: 435-444. PMID 16869781 DOI: 10.1101/Sqb.2005.70.031  0.587
2005 Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 121: 837-48. PMID 15960972 DOI: 10.1016/J.Cell.2005.03.033  0.63
2004 Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, et al. A resource for large-scale RNA-interference-based screens in mammals. Nature. 428: 427-31. PMID 15042091 DOI: 10.1038/Nature02370  0.523
2002 Westbrook TF, Nguyen DX, Thrash BR, McCance DJ. E7 abolishes raf-induced arrest via mislocalization of p21(Cip1). Molecular and Cellular Biology. 22: 7041-52. PMID 12242284 DOI: 10.1128/Mcb.22.20.7041-7052.2002  0.694
2002 Nguyen DX, Westbrook TF, McCance DJ. Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest. Journal of Virology. 76: 619-32. PMID 11752153 DOI: 10.1128/Jvi.76.2.619-632.2002  0.742
2001 Mcmurray HR, Nguyen D, Westbrook TF, Mcance DJ. Biology of human papillomaviruses International Journal of Experimental Pathology. 82: 15-33. PMID 11422538 DOI: 10.1046/J.1365-2613.2001.00177.X  0.739
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