Sendurai A Mani, PhD - Publications

Affiliations: 
2022- Pathology and Lab Medicine Brown University, Providence, RI 
Area:
cell biology, cancer biology
Website:
www.mani.us

126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kuburich NA, den Hollander P, Castaneda M, Pietilä M, Tang X, Batra H, Martínez-Peña F, Visal TH, Zhou T, Demestichas BR, Dontula RV, Liu JY, Maddela JJ, Padmanabhan RS, Phi LTH, ... ... Mani SA, et al. Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas. Cell Reports. 42: 113470. PMID 37979166 DOI: 10.1016/j.celrep.2023.113470  0.453
2023 Kuburich NA, Sabapathy T, Demestichas BR, Maddela JJ, den Hollander P, Mani SA. Proactive and reactive roles of TGF-β in cancer. Seminars in Cancer Biology. 95: 120-139. PMID 37572731 DOI: 10.1016/j.semcancer.2023.08.002  0.402
2023 Fathi M, Martinez-Paniagua M, Rezvan A, Montalvo MJ, Mohanty V, Chen K, Mani SA, Varadarajan N. Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling. Iscience. 26: 106482. PMID 37091228 DOI: 10.1016/j.isci.2023.106482  0.483
2023 Addeo A, Miranda E, den Hollander P, Friedlaender A, Sintim H, Wu J, Mani SA, Subbiah V. RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives. Pharmacology & Therapeutics. 108344. PMID 36632846 DOI: 10.1016/j.pharmthera.2023.108344  0.341
2022 Castaneda M, den Hollander P, Kuburich NA, Rosen JM, Mani SA. Mechanisms of cancer metastasis. Seminars in Cancer Biology. 87: 17-31. PMID 36354098 DOI: 10.1016/j.semcancer.2022.10.006  0.801
2022 Aouad P, Zhang Y, De Martino F, Stibolt C, Ali S, Ambrosini G, Mani SA, Maggs K, Quinn HM, Sflomos G, Brisken C. Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nature Communications. 13: 4975. PMID 36008376 DOI: 10.1038/s41467-022-32523-6  0.386
2022 Martínez-Peña F, Pearson AD, Tang EL, Kuburich NA, Mani SA, Schultz PG, Bollong MJ, Lairson LL. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. European Journal of Medicinal Chemistry. 242: 114638. PMID 36001933 DOI: 10.1016/j.ejmech.2022.114638  0.81
2022 den Hollander P, Joseph R, Vasaikar S, Kuburich NA, Deshmukh AP, Mani SA. Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 2429: 547-554. PMID 35507188 DOI: 10.1007/978-1-0716-1979-7_38  0.827
2022 Kuburich NA, den Hollander P, Deshmukh AP, Vasaikar S, Joseph R, Wicha MS, Mani SA. In Vitro Quantification of Cancer Stem Cells Using a Mammosphere Formation Assay. Methods in Molecular Biology (Clifton, N.J.). 2429: 509-513. PMID 35507185 DOI: 10.1007/978-1-0716-1979-7_35  0.827
2022 Deshmukh AP, den Hollander P, Kuburich NA, Vasaikar S, Joseph R, Mani SA. Enrichment of Cancer Stem Cells in a Tumorsphere Assay. Methods in Molecular Biology (Clifton, N.J.). 2429: 501-507. PMID 35507184 DOI: 10.1007/978-1-0716-1979-7_34  0.818
2022 Kudaravalli S, den Hollander P, Mani SA. Role of p38 MAP kinase in cancer stem cells and metastasis. Oncogene. 41: 3177-3185. PMID 35501462 DOI: 10.1038/s41388-022-02329-3  0.413
2022 Castaneda M, den Hollander P, Mani SA. Forkhead box transcription factors: double-edged swords in cancer. Cancer Research. PMID 35315926 DOI: 10.1158/0008-5472.CAN-21-3371  0.332
2022 Wu L, Amjad S, Yun H, Mani S, de Perrot M. A panel of emerging EMT genes identified in malignant mesothelioma. Scientific Reports. 12: 1007. PMID 35046456 DOI: 10.1038/s41598-022-04973-x  0.359
2021 Kuburich NA, den Hollander P, Pietz JT, Mani SA. Vimentin and cytokeratin: good alone, bad together. Seminars in Cancer Biology. PMID 34953942 DOI: 10.1016/j.semcancer.2021.12.006  0.808
2021 Balcik-Ercin P, Cayrefourcq L, Soundararajan R, Mani SA, Alix-Panabières C. Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer. Cancers. 13. PMID 34771571 DOI: 10.3390/cancers13215408  0.488
2021 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, ... ... Mani SA, et al. Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology. PMID 34654908 DOI: 10.1038/s41580-021-00428-9  0.411
2021 Fathi M, Joseph R, Adolacion JRT, Martinez-Paniagua M, An X, Gabrusiewicz K, Mani SA, Varadarajan N. Single-Cell Cloning of Breast Cancer Cells Secreting Specific Subsets of Extracellular Vesicles. Cancers. 13. PMID 34503207 DOI: 10.3390/cancers13174397  0.45
2021 Satpathy S, Krug K, Jean Beltran PM, Savage SR, Petralia F, Kumar-Sinha C, Dou Y, Reva B, Kane MH, Avanessian SC, Vasaikar SV, Krek A, Lei JT, Jaehnig EJ, Omelchenko T, ... ... Mani SA, et al. A proteogenomic portrait of lung squamous cell carcinoma. Cell. 184: 4348-4371.e40. PMID 34358469 DOI: 10.1016/j.cell.2021.07.016  0.345
2021 Zhao N, Powell RT, Yuan X, Bae G, Roarty KP, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition. Nature Communications. 12: 4262. PMID 34253738 DOI: 10.1038/s41467-021-24545-3  0.383
2021 Bushnell GG, Deshmukh AP, den Hollander P, Luo M, Soundararajan R, Jia D, Levine H, Mani SA, Wicha MS. Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge. Npj Breast Cancer. 7: 66. PMID 34050189 DOI: 10.1038/s41523-021-00269-x  0.362
2021 Deshmukh AP, Vasaikar SV, Tomczak K, Tripathi S, den Hollander P, Arslan E, Chakraborty P, Soundararajan R, Jolly MK, Rai K, Levine H, Mani SA. Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33941680 DOI: 10.1073/pnas.2102050118  0.307
2021 Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, ... ... Mani SA, et al. CD8 T cells inhibit metastasis and CXCL4 regulates its function. British Journal of Cancer. PMID 33795809 DOI: 10.1038/s41416-021-01338-5  0.578
2020 Vasaikar SV, Deshmukh AP, den Hollander P, Addanki S, Kuburich NA, Kudaravalli S, Joseph R, Chang JT, Soundararajan R, Mani SA. EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures. British Journal of Cancer. PMID 33299129 DOI: 10.1038/s41416-020-01178-9  0.819
2020 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, ... ... Mani SA, et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology. PMID 32300252 DOI: 10.1038/S41580-020-0237-9  0.531
2020 Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, ... ... Mani SA, et al. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. PMID 32214199 DOI: 10.1038/S41388-020-1252-1  0.372
2020 Soundararajan R, Hollander Pd, Shepherd P, Navone N, Lorenzini D, Laberiano-Fernandez C, Lu W, Zhou J, Liu J, Zhang J, Solis-Soto LM, Mani SA, Aparicio A. Abstract 5443: Modulating plasticity in aggressive variant prostate cancers Cancer Research. 80: 5443-5443. DOI: 10.1158/1538-7445.Am2020-5443  0.435
2020 Kuburich NA, Rosolen M, Martinez F, Hollander Pd, Bollong MJ, Soundararajan R, Lairson LL, Mani SA. Abstract 5043: A vimentin binding small molecule (FiVe1) is a novel candidate to target CSC-rich TNBC Cancer Research. 80: 5043-5043. DOI: 10.1158/1538-7445.Am2020-5043  0.56
2019 Ramirez-Peña E, Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, Bhangre N, Allegakoen P, Prasad R, Conley Z, Matés JM, Márquez J, Chang JT, Vasaikar S, Soundararajan R, ... ... Mani SA, et al. The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing Expression. Cancers. 11. PMID 31652551 DOI: 10.3390/Cancers11101610  0.598
2019 Jia W, Deshmukh A, Mani SA, Jolly MK, Levine H. A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT). Physical Biology. PMID 31342918 DOI: 10.1088/1478-3975/Ab34Df  0.381
2019 Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Nagi C, Sikora AG, Rowley D, ... ... Mani SA, et al. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. PMID 31308490 DOI: 10.1038/S41388-019-0885-4  0.457
2019 Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, ... ... Mani SA, et al. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers. 11. PMID 31137625 DOI: 10.3390/Cancers11050714  0.712
2019 Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, ... ... Mani SA, et al. GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Research : Bcr. 21: 37. PMID 30845991 DOI: 10.1186/S13058-019-1125-0  0.572
2019 Soundararajan R, Allegakoen P, Hollander Pd, Paranjape A, Joseph R, Sundaram S, Karunagaran D, Shepherd P, Navone N, Aparicio A, Maity S, Broom B, Logothetis C, Mani S. Abstract 4674: Targeting cancer stem-cells in aggressive variant prostate cancers Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4674  0.481
2019 Hollander Pd, Shah S, Zhou X, Redwood A, Cai S, Sobieski M, Brunell D, Stephan C, Davies P, Piwnica-Worms H, Moulder S, Symmans WF, Mani SA. Abstract 4669: Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition Cancer Research. 79: 4669-4669. DOI: 10.1158/1538-7445.Am2019-4669  0.517
2019 Joseph R, Soundararajan R, Vasaikar S, Yang F, Isgandarova S, Tian L, Haemmerle M, Mino B, Zhou T, Raja GV, Pena ER, Hollander PD, Bhangre N, Shin C, Martinez M, ... ... Mani SA, et al. Abstract 3761: Regulation of metastasis by CD8 T lymphocytes Cancer Research. 79: 3761-3761. DOI: 10.1158/1538-7445.Am2019-3761  0.525
2019 Fathi M, Joseph R, Martinez-Paniagua M, Adolacion JR, An X, Mahendra A, Gabrusiewicz K, Chatterjee S, Mani SA, Varadarajan N. Abstract 2907: Exosome secretion is an inheritable property of cancer cells: Single-cell profiling of exosome secretion Cancer Research. 79: 2907-2907. DOI: 10.1158/1538-7445.Am2019-2907  0.545
2018 Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, ... ... Mani SA, et al. A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. Cell Systems. PMID 30268436 DOI: 10.1016/J.Cels.2018.08.010  0.35
2018 Jolly MK, Mani SA, Levine H. Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis? Biochimica Et Biophysica Acta. PMID 29997040 DOI: 10.1016/J.Bbcan.2018.07.001  0.501
2018 Soundararajan R, Paranjape AN, Maity S, Aparicio A, Mani SA. EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers. Biochimica Et Biophysica Acta. PMID 29981816 DOI: 10.1016/J.Bbcan.2018.06.006  0.493
2018 Soundararajan R, Aparicio AM, Logothetis CJ, Mani SA, Maity SN. Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. Frontiers in Oncology. 8: 69. PMID 29600194 DOI: 10.3389/Fonc.2018.00069  0.427
2018 Soundararajan R, Paranjape A, Joseph R, Bhangre N, Aparicio A, Maity S, Logothetis C, Chang J, Mani S. Abstract A065: Modulating a cancer stem cell-specific signaling pathway to reverse the course of neuroendocrine prostate cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A065  0.512
2017 Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087350 DOI: 10.1073/Pnas.1716009114  0.579
2017 Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 8: 65548-65565. PMID 29029452 DOI: 10.18632/Oncotarget.19214  0.561
2017 Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Jin Song J, Chang JT, Gyu Lee M, Soundararajan R, Mani SA. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. PMID 28747563 DOI: 10.18632/oncotarget.19214  0.477
2017 Yam C, Mani SA, Moulder SL. Targeting the Molecular Subtypes of Triple Negative Breast Cancer: Understanding the Diversity to Progress the Field. The Oncologist. 22: 1086-1093. PMID 28559413 DOI: 10.1634/Theoncologist.2017-0095  0.432
2017 Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, ... ... Mani SA, et al. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biology. 18: 98. PMID 28535802 DOI: 10.1186/S13059-017-1224-0  0.389
2017 Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. PMID 28371798 DOI: 10.1038/Nature21724  0.319
2017 Baez Vallecillo L, Chang JT, Chen K, Moss TJ, Shaw KR, Meric-Bernstam F, Eterovic AK, Mills GB, Mani S, Li X(, Gilcrease M, Moulder SL. Whole exome sequencing of metaplastic breast cancer (MpBC): Effect of mutation status on survival. Journal of Clinical Oncology. 35: 1090-1090. DOI: 10.1200/Jco.2017.35.15_Suppl.1090  0.318
2017 Arnold J, Rasaily U, Ramirez-Peña E, Pathak R, Martin RS, Purwaha P, Rao A, Putluri N, Rowley D, Sikora A, Mani S, Sreekumar A. Abstract P6-02-02: Uridine diphosphate glucose dehydrogenase is required for hyaluronic acid production and breast cancer invasion Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P6-02-02  0.363
2017 Jolly MK, Jia D, Tripathi SC, Mooney S, Celiktas M, Hanash SM, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. Abstract 3053: Stability and stemness of the hybrid epithelial-mesenchymal phenotype Cancer Research. 77: 3053-3053. DOI: 10.1158/1538-7445.Am2017-3053  0.377
2016 Toneff MJ, Sreekumar A, Tinnirello A, Hollander PD, Habib S, Li S, Ellis MJ, Xin L, Mani SA, Rosen JM. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. Bmc Biology. 14: 47. PMID 27317311 DOI: 10.1186/S12915-016-0269-Y  0.547
2016 Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. The Journal of Clinical Investigation. PMID 27294523 DOI: 10.1172/Jci84637  0.424
2016 Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Ramirez-Peña EQ, Soundararajan R, den Hollander P, Powell E, Echeverria GV, Miura N, Chang JT, Piwnica-Worms H, ... ... Mani SA, et al. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene. PMID 27292262 DOI: 10.1038/Onc.2016.203  0.528
2016 Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. PMID 27259233 DOI: 10.18632/Oncotarget.9730  0.533
2016 Boareto M, Jolly MK, Goldman A, Pietilä M, Mani SA, Sengupta S, Ben-Jacob E, Levine H, Onuchic JN. Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. Journal of the Royal Society, Interface / the Royal Society. 13. PMID 27170649 DOI: 10.1098/Rsif.2015.1106  0.436
2016 Pietilä M, Vijay GV, Soundararajan R, Yu X, Symmans WF, Sphyris N, Mani SA. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Scientific Reports. 6: 23070. PMID 27064522 DOI: 10.1038/Srep23070  0.562
2016 Jolly MK, Tripathi SC, Jia D, Mooney SM, Celiktas M, Hanash SM, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. Stability of the hybrid epithelial/mesenchymal phenotype. Oncotarget. PMID 27008704 DOI: 10.18632/Oncotarget.8166  0.449
2016 Dhawan A, Madani Tonekaboni SA, Taube JH, Hu S, Sphyris N, Mani SA, Kohandel M. Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia. Scientific Reports. 6: 18074. PMID 26838463 DOI: 10.1038/Srep18074  0.528
2016 Zhao W, Prijic S, Urban BC, Tisza MJ, Zuo Y, Li L, Tan Z, Chen X, Mani SA, Chang JT. Candidate anti-metastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity. Cancer Research. PMID 26825169 DOI: 10.1158/0008-5472.Can-15-1970  0.559
2016 Paranjape AN, Soundararajan R, Werden SJ, Joseph R, Taube JH, Liu H, Rodriguez-Canales J, Sphyris N, Wistuba I, Miura N, Dhillon J, Mahajan N, Mahajan K, Chang JT, Ittmann M, ... ... Mani SA, et al. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties. Oncogene. PMID 26804168 DOI: 10.1038/Onc.2015.498  0.498
2016 Pietilä M, Ivaska J, Mani SA. Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment? Cancer Letters. 380: 359-68. PMID 26791236 DOI: 10.1016/J.Canlet.2015.12.033  0.479
2016 Joseph R, Soundararajan R, Paranjape A, Mani S. Abstract A130: Immune regulation of EMT and metastatic competence in breast tumor progression Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A130  0.543
2016 Joseph R, Soundararajan R, Paranjape A, Mani S. Abstract 5141: Determinants of metastatic competence in breast carcinoma: a role for immune cells Cancer Research. 76: 5141-5141. DOI: 10.1158/1538-7445.Am2016-5141  0.548
2016 Kumar M, DeVaux RS, Shen JJ, Davis SP, Dinger ME, Mattick JS, Perou CM, Rosen JM, Mani SA, Herschkowitz JI. Abstract 1598: LncRNA AK001796 as a therapeutic target in aggressive breast cancers Cancer Research. 76: 1598-1598. DOI: 10.1158/1538-7445.Am2016-1598  0.555
2016 Pietilä M, Ivaska J, Mani SA. Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment? Cancer Letters. DOI: 10.1016/j.canlet.2015.12.033  0.328
2015 Sphyris N, Sarkar TR, Battula VL, Andreeff M, Mani SA. GD2 and GD3 synthase: novel drug targets for cancer therapy. Molecular & Cellular Oncology. 2: e975068. PMID 27308452 DOI: 10.4161/23723556.2014.975068  0.565
2015 Jolly MK, Jia D, Boareto M, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. Coupling the modules of EMT and stemness: A tunable 'stemness window' model. Oncotarget. PMID 26317796 DOI: 10.18632/Oncotarget.4629  0.462
2015 Bhowmik SK, Ramirez-Peña E, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA. EMT-Induced Metabolite Signature Identifies Poor Clinical Outcome. Oncotarget. PMID 26315396 DOI: 10.18632/Oncotarget.4765  0.526
2015 Cohen EN, Gao H, Anfossi S, Mego M, Reddy NG, Debeb B, Giordano A, Tin S, Wu Q, Garza RJ, Cristofanilli M, Mani SA, Croix DA, Ueno NT, Woodward WA, et al. Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells. Plos One. 10: e0132710. PMID 26207636 DOI: 10.1371/Journal.Pone.0132710  0.545
2015 Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani SA. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Scientific Reports. 5: 11766. PMID 26123483 DOI: 10.1038/Srep11766  0.501
2015 Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, ... ... Mani SA, et al. Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. Blood. 125: 2968-73. PMID 25712988 DOI: 10.1182/Blood-2014-05-576421  0.392
2015 Sarkar TR, Battula VL, Werden SJ, Vijay GV, Ramirez-Peña EQ, Taube JH, Chang JT, Miura N, Porter W, Sphyris N, Andreeff M, Mani SA. GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene. 34: 2958-67. PMID 25109336 DOI: 10.1038/Onc.2014.245  0.595
2015 Jolly MK, Huang B, Lu M, Mani SA, Levine H, Ben-Jacob E. Abstract B2-49: Coupled cellular decision-making of EMT and stemness: A bottom-up regulatory model Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B2-49  0.427
2015 Zhao W, Sara P, Urban B, Tisza M, Mani SA, Chang JT. Abstract B2-10: Systems biology reveals role of cholesterol homeostasis in breast cancer metastasis Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B2-10  0.511
2015 Paranjape AN, Soundararajan R, Werden SJ, Joseph R, Taube JH, Bhangre N, Liu H, Rodriguez-Canales J, Wistuba II, Chang JT, Tang DG, Mahajan N, Mahajan K, Miura N, Mani SA. Abstract 4065: Delineating the role of epithelial-mesenchymal transition in the generation and maintenance of prostate cancer stem cells Cancer Research. 75: 4065-4065. DOI: 10.1158/1538-7445.Am2015-4065  0.579
2015 Mitra S, Federico L, Roysarkar T, Mani S, Mills GB. Abstract 4040: Transcription factor Snail mediates EMT by altering vesicular trafficking protein Rab25 Cancer Research. 75: 4040-4040. DOI: 10.1158/1538-7445.Am2015-4040  0.584
2014 Jolly MK, Huang B, Lu M, Mani SA, Levine H, Ben-Jacob E. Towards elucidating the connection between epithelial-mesenchymal transitions and stemness. Journal of the Royal Society, Interface / the Royal Society. 11: 20140962. PMID 25339690 DOI: 10.1098/Rsif.2014.0962  0.379
2014 Krohn A, Ahrens T, Yalcin A, Plönes T, Wehrle J, Taromi S, Wollner S, Follo M, Brabletz T, Mani SA, Claus R, Hackanson B, Burger M. Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT) and DNA methylation changes. Plos One. 9: e100249. PMID 24959847 DOI: 10.1371/Journal.Pone.0100249  0.566
2014 Zhao W, Tisza M, Sjol J, Mani S, Chang JT. Abstract 2080: Plasma membrane fluidity drives metastasis in breast cancer Cancer Research. 74: 2080-2080. DOI: 10.1158/1538-7445.Am2014-2080  0.48
2013 Malouf GG, Taube JH, Lu Y, Roysarkar T, Panjarian S, Estecio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, ... Mani SA, et al. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biology. 14: R144. PMID 24367927 DOI: 10.1186/Gb-2013-14-12-R144  0.463
2013 Taube JH, Malouf GG, Lu E, Sphyris N, Vijay V, Ramachandran PP, Ueno KR, Gaur S, Nicoloso MS, Rossi S, Herschkowitz JI, Rosen JM, Issa JP, Calin GA, Chang JT, ... Mani SA, et al. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Scientific Reports. 3: 2687. PMID 24045437 DOI: 10.1038/Srep02687  0.494
2013 Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, ... ... Mani SA, et al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Research. 23: 1446-61. PMID 23796952 DOI: 10.1101/Gr.152942.112  0.402
2013 Zarkoob H, Taube JH, Singh SK, Mani SA, Kohandel M. Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein. Plos One. 8: e64169. PMID 23734191 DOI: 10.1371/Journal.Pone.0064169  0.405
2013 Chang JT, Mani SA. Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition. Cancer Letters. 341: 16-23. PMID 23499890 DOI: 10.1016/J.Canlet.2013.03.004  0.618
2013 Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, ... Mani SA, et al. FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Research. 73: 1981-92. PMID 23378344 DOI: 10.1158/0008-5472.Can-12-2962  0.633
2013 Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, Maru DM, Hawke DH, Rak J, Mani SA, Zweidler-McKay P, et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 23: 171-85. PMID 23375636 DOI: 10.1016/J.Ccr.2012.12.021  0.527
2013 Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Science Signaling. 6: ra2. PMID 23300339 DOI: 10.1126/Scisignal.2003295  0.311
2013 Herschkowitz JI, Coarfa C, Prat A, Toneff MJ, Hoadley KA, Dinger ME, Mattick JS, Mani SA, Perou CM, Rosen JM. Abstract A039: The role of long noncoding RNAs in epithelial to mesenchymal transition and cancer stem cells Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A039  0.547
2013 Barsan V, Cristofanilli M, Mani S. Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition Breast Diseases: a Year Book Quarterly. 24: 225-226. DOI: 10.1016/J.Breastdis.2013.07.021  0.448
2012 Fan F, Samuel S, Evans KW, Lu J, Xia L, Zhou Y, Sceusi E, Tozzi F, Ye XC, Mani SA, Ellis LM. Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells. Cancer Medicine. 1: 5-16. PMID 23342249 DOI: 10.1002/Cam4.4  0.619
2012 Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee BN, Tin S, De Laurentiis M, Parker CA, Alvarez RH, Valero V, Ueno NT, De Placido S, Mani SA, Esteva FJ, et al. Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Molecular Cancer Therapeutics. 11: 2526-34. PMID 22973057 DOI: 10.1158/1535-7163.Mct-12-0460  0.386
2012 Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani SA, Andreeff M. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. The Journal of Clinical Investigation. 122: 2066-78. PMID 22585577 DOI: 10.1172/Jci59735  0.63
2012 Román-Pérez E, Casbas-Hernández P, Pirone JR, Rein J, Carey LA, Lubet RA, Mani SA, Amos KD, Troester MA. Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Research : Bcr. 14: R51. PMID 22429463 DOI: 10.1186/Bcr3152  0.418
2012 Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 148: 1015-28. PMID 22385965 DOI: 10.1016/J.Cell.2012.02.008  0.763
2012 Kolonin MG, Evans KW, Mani SA, Gomer RH. Alternative origins of stroma in normal organs and disease. Stem Cell Research. 8: 312-23. PMID 22209011 DOI: 10.1016/J.Scr.2011.11.005  0.441
2012 Walia V, Yu Y, Cao D, Sun M, McLean JR, Hollier BG, Cheng J, Mani SA, Rao K, Premkumar L, Elble RC. Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis. Oncogene. 31: 2237-46. PMID 21909135 DOI: 10.1038/Onc.2011.392  0.578
2012 Mego M, Mani SA, Lee BN, Li C, Evans KW, Cohen EN, Gao H, Jackson SA, Giordano A, Hortobagyi GN, Cristofanilli M, Lucci A, Reuben JM. Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy. International Journal of Cancer. Journal International Du Cancer. 130: 808-16. PMID 21387303 DOI: 10.1002/Ijc.26037  0.519
2012 Battula VL, Shi Y, Evans K, Wang R, Speath EL, Jacamo R, Guerra R, Sahin A, Marini F, Mani S, Andreeff M. Abstract LB-193: Ganglioside GD2 identifies cancer stem cells and inhibition of GD2 biosynthesis by targeting GD3 synthase exerts antitumor effects Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-193  0.61
2011 Tong Z, Chakraborty S, Sung B, Koolwal P, Kaur S, Aggarwal BB, Mani SA, Bresalier RS, Batra SK, Guha S. Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells. Cancer. 117: 2408-18. PMID 24048788 DOI: 10.1002/Cncr.25803  0.379
2011 Sphyris N, Mani SA. pIgR: frenemy of inflammation, EMT, and HCC progression. Journal of the National Cancer Institute. 103: 1644-5. PMID 22025623 DOI: 10.1093/Jnci/Djr421  0.436
2011 Mani SA, Barton MC. HDAC3 at the fulcrum of an epithelial-mesenchymal balance. Molecular Cell. 43: 697-8. PMID 21884971 DOI: 10.1016/J.Molcel.2011.08.012  0.569
2011 May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA. Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Research : Bcr. 13: 202. PMID 21392411 DOI: 10.1186/Bcr2789  0.749
2011 Tong Z, Chakraborty S, Sung B, Kaur S, Aggarwal BB, Mani S, Bresalier RS, Batra S, Guha S. Abstract 5008: Epidermal growth factor downregulates expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells Cancer Research. 71: 5008-5008. DOI: 10.1158/1538-7445.Am2011-5008  0.429
2011 Casbas-Hernandez P, Roman-Perez E, Mani S, Troester M. P1-03-04: In-Vitro Characterization of a Breast Cancer Microenvironment with Epithelial-to-Mesenchymal Transition (EMT) Characteristics. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P1-03-04  0.613
2011 Andreeff M, Battula VL, Wang R, Chen Y, Ling X, Jacamo R, Spaeth E, Konoplev S, Burks J, Hazen A, Schober W, Lu H, Mak D, McQueen T, Shi Y, ... ... Mani S, et al. 900 Multipotent Mesenchymal Stromal Cells (MSC) - Evolving Role in Cancer and Leukemia Therapy Clinical Lymphoma Myeloma and Leukemia. 11: S134-S135. DOI: 10.1016/J.Clml.2011.05.033  0.513
2010 Mego M, Mani SA, Cristofanilli M. Molecular mechanisms of metastasis in breast cancer--clinical applications. Nature Reviews. Clinical Oncology. 7: 693-701. PMID 20956980 DOI: 10.1038/Nrclinonc.2010.171  0.463
2010 Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, ... Mani SA, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 15449-54. PMID 20713713 DOI: 10.1073/Pnas.1004900107  0.639
2010 Battula VL, Evans KW, Hollier BG, Shi Y, Marini FC, Ayyanan A, Wang RY, Brisken C, Guerra R, Andreeff M, Mani SA. Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells (Dayton, Ohio). 28: 1435-45. PMID 20572012 DOI: 10.1002/Stem.467  0.544
2010 Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. Journal of Mammary Gland Biology and Neoplasia. 15: 235-52. PMID 20521089 DOI: 10.1007/S10911-010-9175-Z  0.626
2010 Battula VL, Evans K, Hollier BG, Shi Y, Marini FC, Ayyanan A, Brisken C, Guerra R, Andreeff M, Mani SA. Abstract 2314: Epithelial-mesenchymal transition derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells Cancer Research. 70: 2314-2314. DOI: 10.1158/1538-7445.Am10-2314  0.579
2010 Fan F, Evans KW, Mani SA, Zhou Y, Samuel S, Lu J, Xia L, Sceusi E, Tozzi F, Ye X, Ellis LM. Abstract 2300: Overexpression of Snail induces epithelial-mesenchymal transition and cancer stem cell-like phenotypes in CRC cells Cancer Research. 70: 2300-2300. DOI: 10.1158/1538-7445.Am10-2300  0.617
2010 Lu J, Bose D, Zhou Y, Gaur P, Samuel S, Fan F, Xia L, Ye X, Sceusi E, Tozzi F, Mani SA, Ellis LM. Abstract 1281: Endothelial cells promote the cancer stem cell phenotype of human colorectal cancer cells Cancer Research. 70: 1281-1281. DOI: 10.1158/1538-7445.Am10-1281  0.513
2010 Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, ... Mani SA, et al. Erratum: Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudinlow and metaplastic breast cancer subtypes (Proceedings of the National Academy of Sciences of the United States of America (2010) 107:35 (15449-15454)) Proceedings of the National Academy of Sciences of the United States of America. 107. DOI: 10.1073/Pnas.1015095107  0.574
2009 Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, Hortobagyi GN, Yu D. Breast cancer metastasis: challenges and opportunities. Cancer Research. 69: 4951-3. PMID 19470768 DOI: 10.1158/0008-5472.Can-09-0099  0.451
2009 Hollier BG, Evans K, Mani SA. The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies. Journal of Mammary Gland Biology and Neoplasia. 14: 29-43. PMID 19242781 DOI: 10.1007/S10911-009-9110-3  0.64
2009 Mego M, Mani S, Li C, Andreoupolou E, Tin S, Jackson S, Cohen E, Gao H, Cristofanilli M, Reuben J. Circulating Tumor Cells (CTCs) and Epithelial Mesenchymal Transition (EMT) in Breast Cancer: Describing the Heterogeneity of Microscopic Disease. Cancer Research. 69: 3011-3011. DOI: 10.1158/0008-5472.Sabcs-09-3011  0.496
2009 Sphyris N, Mani SA. The importance of the epithelial-mesenchymal transition in breast cancer Current Breast Cancer Reports. 1: 229-237. DOI: 10.1007/S12609-009-0032-2  0.593
2008 Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani SA, Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, et al. Cell type-specific DNA methylation patterns in the human breast. Proceedings of the National Academy of Sciences of the United States of America. 105: 14076-81. PMID 18780791 DOI: 10.1073/Pnas.0805206105  0.479
2008 Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133: 704-15. PMID 18485877 DOI: 10.1016/J.Cell.2008.03.027  0.767
2008 Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Research. 68: 3645-54. PMID 18483246 DOI: 10.1158/0008-5472.Can-07-2938  0.55
2007 Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA. Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Research. 67: 8131-8. PMID 17804725 DOI: 10.1158/0008-5472.Can-06-4493  0.732
2007 Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proceedings of the National Academy of Sciences of the United States of America. 104: 10069-74. PMID 17537911 DOI: 10.1073/Pnas.0703900104  0.705
2006 Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Research. 66: 4549-52. PMID 16651402 DOI: 10.1158/0008-5472.Can-05-3850  0.619
2005 Gupta PB, Mani S, Yang J, Hartwell K, Weinberg RA. The evolving portrait of cancer metastasis. Cold Spring Harbor Symposia On Quantitative Biology. 70: 291-7. PMID 16869765 DOI: 10.1101/Sqb.2005.70.033  0.646
2004 Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117: 927-39. PMID 15210113 DOI: 10.1016/J.Cell.2004.06.006  0.667
2001 Hahn W, Elenbaas B, Stewart S, Watnick R, Yang J, Mani S, Weinberg R. Rules governing the creation of human tumor cells European Journal of Cancer. 37: S369. DOI: 10.1016/S0959-8049(01)81861-X  0.647
Show low-probability matches.