☰

Michele Leuenberger - Publications

Affiliations: 
2003 Chemistry Universität Basel, Basel, Basel-Stadt, Switzerland 
Tree Info Similar researchers PubMed Report error

15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Preti B, Suchankova A, Deganutti G, Leuenberger M, Barkan K, Manulak I, Huang X, Carvalho S, Ladds G, Lochner M. Discovery and Structure-Activity Relationship Studies of Novel Adenosine A Receptor-Selective Agonists. Journal of Medicinal Chemistry. 65: 14864-14890. PMID 36270633 DOI: 10.1021/acs.jmedchem.2c01414  0.654
2022 Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, et al. Selective activation of Gαob by an adenosine A receptor agonist elicits analgesia without cardiorespiratory depression. Nature Communications. 13: 4150. PMID 35851064 DOI: 10.1038/s41467-022-31652-2  0.648
2021 Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. The Journal of Pharmacology and Experimental Therapeutics. PMID 33782042 DOI: 10.1124/jpet.120.000449  0.598
2021 Deganutti G, Barkan K, Preti B, Leuenberger M, Wall M, Frenguelli BG, Lochner M, Ladds G, Reynolds CA. Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. Acs Pharmacology & Translational Science. 4: 314-326. PMID 33615181 DOI: 10.1021/acsptsci.0c00195  0.661
2020 Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G. Correction to Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. Journal of Medicinal Chemistry. PMID 32870678 DOI: 10.1021/acs.jmedchem.0c01416  0.648
2019 French RR, Holzer P, Leuenberger MG, Woggon WD. A Supramolecular Enzyme Mimic That Catalyzes the 15,15' Double Bond Scission of beta,beta-Carotene This research was supported by the Swiss National Science Foundation, Novartis International AG, and F. Hoffmann-La Roche AG. We are grateful to F. Hoffmann-La Roche AG for the generous gift of carotenoids, and we also thank Prof. Dr. Jakob Wirz, Insitut für Physikalische Chemie der Universität Basel, for the calculation of the binding constant K(a) of 1 to the receptor 3. Angewandte Chemie (International Ed. in English). 39: 1267-1269. PMID 10767027 DOI: 10.1002/(SICI)1521-3773(20000403)39:7<1267::AID-ANIE1267>3.0.CO;2-7  0.749
2018 Jack T, Leuenberger M, Ruepp MD, Vernekar SKV, Thompson AJ, Braga-Lagache S, Heller M, Lochner M. Mapping the Orthosteric Binding Site of the Human 5-HT Receptor Using Photo-crosslinking Antagonists. Acs Chemical Neuroscience. PMID 30149702 DOI: 10.1021/acschemneuro.8b00327  0.642
2017 Ruepp MD, Wei H, Leuenberger M, Lochner M, Thompson AJ. The binding orientations of structurally-related ligands can differ; A cautionary note. Neuropharmacology. PMID 28137449 DOI: 10.1016/j.neuropharm.2017.01.023  0.645
2016 Leuenberger M, Ritler A, Simonin A, Hediger MA, Lochner M. Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. Acs Chemical Neuroscience. 7: 534-9. PMID 26918289 DOI: 10.1021/acschemneuro.5b00311  0.615
2016 Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G. Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity. Journal of Medicinal Chemistry. PMID 26756468 DOI: 10.1021/acs.jmedchem.5b01402  0.646
2013 Hofer A, Kovacs G, Zappatini A, Leuenberger M, Hediger MA, Lochner M. Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic & Medicinal Chemistry. 21: 3202-13. PMID 23602525 DOI: 10.1016/j.bmc.2013.03.037  0.596
2013 Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular Aspects of Medicine. 34: 108-20. PMID 23506861 DOI: 10.1016/j.mam.2013.01.001  0.605
2002 French RR, Holzer P, Leuenberger M, Nold MC, Woggon WD. A supramolecular enzyme model catalyzing the central cleavage of carotenoids. Journal of Inorganic Biochemistry. 88: 295-304. PMID 11897343  0.698
2001 Leuenberger MG, Engeloch-Jarret C, Woggon WD. The Reaction Mechanism of the Enzyme-Catalyzed Central Cleavage of β-Carotene to Retinal. Angewandte Chemie (International Ed. in English). 40: 2613-2617. PMID 29712336 DOI: 10.1002/1521-3773(20010716)40:14<2613::AID-ANIE2613>3.0.CO;2-Z  0.66
2001 Leuenberger MG, Engeloch-Jarret C, Woggon WD. The Reaction Mechanism of the Enzyme-Catalyzed Central Cleavage of beta-Carotene to Retinal This research was supported by F. Hoffmann-La Roche AG and the Swiss National Science Foundation. We are grateful to F. Hoffmann-La Roche AG for a generous gift of carotenoids and Dr. Claus Bornemann for preliminary experiments. Angewandte Chemie (International Ed. in English). 40: 2613-2617. PMID 11458349 DOI: 10.1002/1521-3773(20010716)40:14<2613::AID-ANIE2613>3.0.CO;2-Z  0.677
Show low-probability matches.