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Clint Tavares - Publications

Affiliations: 
2008-2015 Medicinal Chemistry University of Texas at Austin, Austin, Texas, U.S.A. 
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21/32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, et al. Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nature Communications. 10: 5232. PMID 31745079 DOI: 10.1038/S41467-019-12996-8  0.752
2017 Jose J, Tavares CDJ, Ebelt ND, Lodi A, Edupuganti R, Xie X, Devkota AK, Kaoud TS, Van Den Berg CL, Anslyn EV, Tiziani S, Bartholomeusz C, Dalby KN. Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth. Acs Medicinal Chemistry Letters. 8: 1072-1076. PMID 29057053 DOI: 10.1021/Acsmedchemlett.7B00282  0.779
2016 Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN. Signal Integration at Elongation Factor 2 Kinase; the Roles of Calcium, Calmodulin and Ser-500 Phosphorylation. The Journal of Biological Chemistry. PMID 27956550 DOI: 10.1074/Jbc.M116.753277  0.781
2016 Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R. Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure (London, England : 1993). PMID 27499441 DOI: 10.1016/J.Str.2016.06.015  0.791
2016 Tavares CD, Devkota AK, Dalby KN, Cho EJ. Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening. Methods in Molecular Biology (Clifton, N.J.). 1360: 19-33. PMID 26501899 DOI: 10.1007/978-1-4939-3073-9_2  0.811
2016 Kaoud TS, Xie X, Park J, Tavares CDJ, Mitra S, Cano M, Radwan MF, Bartholomeusz C, Dalby KN. Abstract A17: TRPM7 kinase domain is involved in breast tumor cell metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A17  0.772
2015 Wang Q, Edupuganti R, Tavares CD, Dalby KN, Ren P. Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis. Frontiers in Molecular Biosciences. 2: 9. PMID 25988177 DOI: 10.3389/Fmolb.2015.00009  0.712
2015 Warthaka M, Adelmann CH, Kaoud TS, Edupuganti R, Yan C, Johnson WH, Ferguson S, Tavares CD, Pence LJ, Anslyn EV, Ren P, Tsai KY, Dalby KN. Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine. Acs Medicinal Chemistry Letters. 6: 47-52. PMID 25589929 DOI: 10.1021/Ml500198B  0.776
2015 Kaoud TS, Xie X, Park J, Tavares CDJ, Mitra S, Cano M, Sammons RM, Radwan MF, Bartholomeusz C, Dalby KN. Abstract 3569: Inhibition of the TRPM7 kinase domain inhibits breast cancer cell migration and invasion and tumor metastasis Cancer Research. 75: 3569-3569. DOI: 10.1158/1538-7445.Am2015-3569  0.795
2014 Edupuganti R, Wang Q, Tavares CD, Chitjian CA, Bachman JL, Ren P, Anslyn EV, Dalby KN. Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. Bioorganic & Medicinal Chemistry. 22: 4910-6. PMID 25047940 DOI: 10.1016/J.Bmc.2014.06.050  0.789
2014 Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN. The molecular mechanism of eukaryotic elongation factor 2 kinase activation. The Journal of Biological Chemistry. 289: 23901-16. PMID 25012662 DOI: 10.1074/Jbc.M114.577148  0.816
2014 Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN. High-throughput screens for eEF-2 kinase. Journal of Biomolecular Screening. 19: 445-52. PMID 24078616 DOI: 10.1177/1087057113505204  0.816
2014 Tavares CDJ, Jose J, Devkota AK, Park J, Kaoud TS, Anslyn EV, Dalby KN. Abstract 5462: Antiproliferative and cytotoxic activities of 5-(nonyloxy)tryptamine derivatives in breast cancer cells Cancer Research. 74: 5462-5462. DOI: 10.1158/1538-7445.Am2014-5462  0.794
2014 Park J, Wang Q, Kaoud TS, Tavares CDJ, Edupuganti R, Ren P, Dalby KN. Abstract 513: Investigating stress-response pathways in pancreatic cancer cells using novel PERK inhibitors Cancer Research. 74: 513-513. DOI: 10.1158/1538-7445.Am2014-513  0.817
2013 Kaoud TS, Park J, Mitra S, Tavares CDJ, Tseng A, Dalby KN. Abstract 4551: Identification of TRPM7 kinase inhibitors. Cancer Research. 73: 4551-4551. DOI: 10.1158/1538-7445.Am2013-4551  0.787
2013 Tavares CDJ, Ferguson SB, Wellmann RM, Kaoud TS, O'Brien JP, Ozpolat B, Brodbelt JS, Dalby KN. Abstract 2222: Analysis of the autophosphorylation-induced calcium-independent activity of human elongation factor 2 kinase (eEF-2K) - a therapeutic target for breast cancer. Cancer Research. 73: 2222-2222. DOI: 10.1158/1538-7445.Am2013-2222  0.852
2012 Tekedereli I, Alpay SN, Tavares CD, Cobanoglu ZE, Kaoud TS, Sahin I, Sood AK, Lopez-Berestein G, Dalby KN, Ozpolat B. Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. Plos One. 7: e41171. PMID 22911754 DOI: 10.1371/Journal.Pone.0041171  0.806
2012 Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry. 51: 2100-12. PMID 22352903 DOI: 10.1021/Bi201787P  0.812
2012 Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence. Biochemistry. 51: 2232-45. PMID 22329831 DOI: 10.1021/Bi201788E  0.784
2012 Abramczyk O, Tavares CDJ, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Corrigendum to "Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli" [Protein Expression and Purification 79 (2011) 237-244] (DOI:10.1016/j.pep.2011.05.005) Protein Expression and Purification. DOI: 10.1016/J.Pep.2012.07.010  0.8
2011 Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli. Protein Expression and Purification. 79: 237-44. PMID 21605678 DOI: 10.1016/J.Pep.2011.05.005  0.838
Low-probability matches (unlikely to be authored by this person)
2021 Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P. A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. Cell Metabolism. PMID 33592173 DOI: 10.1016/j.cmet.2021.01.013  0.214
2020 Luo C, Balsa E, Perry EA, Liang J, Tavares CD, Vazquez F, Widlund HR, Puigserver P. H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP. The Journal of Clinical Investigation. PMID 31929186 DOI: 10.1172/Jci130038  0.184
2016 Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Molecular Cell. PMID 27666594 DOI: 10.1016/J.Molcel.2016.08.023  0.177
2016 Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyl Transferase and the PGC-1α Transcriptional Coactivator. The Journal of Biological Chemistry. PMID 27022023 DOI: 10.1074/Jbc.M115.706200  0.113
2017 Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 169: 148-160.e15. PMID 28340340 DOI: 10.1016/J.Cell.2017.03.001  0.09
2020 Luo C, Liang J, Sharabi K, Hatting M, Perry EA, Tavares CD, Goyal L, Srivastava A, Bilodeau M, Zhu AX, Sicinski P, Puigserver P. Obesity/type 2 diabetes-associated liver tumors are sensitive to Cyclin D1 deficiency. Cancer Research. PMID 32606000 DOI: 10.1158/0008-5472.Can-20-0106  0.087
2020 Tavares CDJ, Aigner S, Sharabi K, Sathe S, Mutlu B, Yeo GW, Puigserver P. Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action. Proceedings of the National Academy of Sciences of the United States of America. PMID 32848060 DOI: 10.1073/Pnas.2000643117  0.083
2017 Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Annals of the New York Academy of Sciences. PMID 28868790 DOI: 10.1111/Nyas.13435  0.058
2016 Rines AK, Sharabi K, Tavares CD, Puigserver P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nature Reviews. Drug Discovery. PMID 27516169 DOI: 10.1038/Nrd.2016.151  0.053
2015 Sharabi K, Tavares CD, Rines AK, Puigserver P. Molecular pathophysiology of hepatic glucose production. Molecular Aspects of Medicine. 46: 21-33. PMID 26549348 DOI: 10.1016/J.Mam.2015.09.003  0.046
2019 Sharabi K, Tavares CDJ, Puigserver P. Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives. Current Diabetes Reports. 19: 98. PMID 31494755 DOI: 10.1007/S11892-019-1224-4  0.027
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