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Gina M DeNicola - Publications

Affiliations: 
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States 
Area:
redox biology, cancer metabolism
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. ASCT2 is the primary serine transporter in cancer cells. Biorxiv : the Preprint Server For Biology. PMID 37873453 DOI: 10.1101/2023.10.09.561530  0.301
2023 DeBlasi JM, Falzone A, Caldwell S, Prieto-Farigua N, Prigge JR, Schmidt EE, Chio IIC, Karreth FA, DeNicola GM. Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Research. PMID 37062029 DOI: 10.1158/0008-5472.CAN-22-3848  0.335
2023 Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biology. 61: 102627. PMID 36841051 DOI: 10.1016/j.redox.2023.102627  0.308
2022 Wang X, Li Y, Li Z, Lin S, Wang H, Sun J, Lan C, Wu L, Sun D, Huang C, Singh PK, Hempel N, Trebak M, DeNicola GM, Hao J, et al. Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer. Cancer Research. PMID 35413105 DOI: 10.1158/0008-5472.CAN-21-3230  0.335
2021 Torrente L, DeNicola GM. Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges. Annual Review of Pharmacology and Toxicology. PMID 34499527 DOI: 10.1146/annurev-pharmtox-052220-104025  0.386
2021 Lin S, Li Y, Wang D, Huang C, Marino D, Bollt O, Wu C, Taylor MD, Li W, DeNicola GM, Hao J, Singh PK, Yang S. Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Letters. 518: 230-242. PMID 34303764 DOI: 10.1016/j.canlet.2021.07.025  0.415
2020 Kang YP, Falzone A, Liu M, González-Sánchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Cancer & Metabolism. 8: 6. PMID 32549981 DOI: 10.1186/S40170-020-00212-X  0.354
2020 Ward NP, DeNicola GM. The Golgi: Keeping It Unapologetically Basic. Cancer Discovery. 10: 768-770. PMID 32482665 DOI: 10.1158/2159-8290.Cd-20-0357  0.362
2020 Harris IS, DeNicola GM. The Complex Interplay between Antioxidants and ROS in Cancer. Trends in Cell Biology. PMID 32303435 DOI: 10.1016/J.Tcb.2020.03.002  0.337
2020 Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. The Journal of Experimental Medicine. 217. PMID 32196080 DOI: 10.1084/Jem.20191689  0.368
2020 Torrente L, Prieto-Farigua N, Falzone A, Elkins CM, Boothman DA, Haura EB, DeNicola GM. Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. Redox Biology. 30: 101440. PMID 32007910 DOI: 10.1016/J.Redox.2020.101440  0.339
2020 Cheung EC, DeNicola GM, Nixon C, Blyth K, Labuschagne CF, Tuveson DA, Vousden KH. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. PMID 31983610 DOI: 10.1016/J.Ccell.2019.12.012  0.587
2019 Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola G. Correction: Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Elife. 8. PMID 31625908 DOI: 10.7554/Elife.52671  0.383
2019 Stewart PA, Welsh EA, Slebos RJC, Fang B, Izumi V, Chambers M, Zhang G, Cen L, Pettersson F, Zhang Y, Chen Z, Cheng CH, Thapa R, Thompson Z, Fellows KM, ... ... DeNicola GM, et al. Proteogenomic landscape of squamous cell lung cancer. Nature Communications. 10: 3578. PMID 31395880 DOI: 10.1038/S41467-019-11452-X  0.303
2019 Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, et al. Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer. Cancer Discovery. PMID 31263025 DOI: 10.1158/2159-8290.Cd-18-1409  0.571
2019 Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola G. Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Elife. 8. PMID 31107239 DOI: 10.7554/Elife.45572  0.432
2019 Combs JA, DeNicola GM. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival. Cancers. 11. PMID 31100816 DOI: 10.3390/cancers11050678  0.336
2019 Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, ... ... DeNicola GM, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metabolism. PMID 30799286 DOI: 10.1016/J.Cmet.2019.01.020  0.464
2019 Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM. Author response: Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer Elife. DOI: 10.7554/Elife.45572.043  0.372
2019 Reverón D, Beato F, DeNicola G, Ortiz A, Centeno B, Jiang K, Jeong D, Malafa M, Hodul P, Deszi K, Permuth J, Fleming J. Abstract C46: Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-C46  0.418
2017 Torrente L, DeNicola GM. Stressing Out PanIN: NRF2 Pushes over the Edge. Cancer Cell. 32: 723-725. PMID 29232549 DOI: 10.1016/J.Ccell.2017.11.014  0.353
2017 Lee SB, Sellers B, DeNicola G. The regulation of NRF2 by nutrient responsive signaling and its role in anabolic cancer metabolism. Antioxidants & Redox Signaling. PMID 28899208 DOI: 10.1089/ars.2017.7356  0.34
2016 Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, ... ... DeNicola GM, et al. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. PMID 27477511 DOI: 10.1016/J.Cell.2016.06.056  0.628
2016 Moon JS, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabón MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature Medicine. PMID 27455510 DOI: 10.1038/Nm.4153  0.326
2016 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 48: 473. PMID 27023779 DOI: 10.1038/Ng0329-473A  0.473
2016 Mullarky E, Lucki NC, Zavareh RB, Anglin JL, Gomes AP, Nicolay BN, Wong JCY, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, et al. Erratum: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (1778-1783) DOI:10.1073/pnas.1521548113) Proceedings of the National Academy of Sciences of the United States of America. 113. PMID 26951666 DOI: 10.1073/Pnas.1602228113  0.487
2016 Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/Pnas.1521548113  0.686
2016 DeNicola GM, Chen P, Mullarky E, Chio C, Asara JM, Minna JD, Tuveson DA, DeBerardinis RJ, Cantley LC. Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B04  0.685
2015 DeNicola GM, Cantley LC. Cancer's Fuel Choice: New Flavors for a Picky Eater. Molecular Cell. 60: 514-23. PMID 26590711 DOI: 10.1016/J.Molcel.2015.10.018  0.527
2015 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. PMID 26482881 DOI: 10.1038/Ng.3421  0.575
2015 DeNicola GM, Karreth FA, Adams DJ, Wong CC. The utility of transposon mutagenesis for cancer studies in the era of genome editing. Genome Biology. 16: 229. PMID 26481584 DOI: 10.1186/S13059-015-0794-Y  0.344
2015 Moon JS, Hisata S, Park MA, DeNicola GM, Ryter SW, Nakahira K, Choi AM. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Reports. 12: 102-15. PMID 26119735 DOI: 10.1016/J.Celrep.2015.05.046  0.336
2014 Emerling BM, Hurov JB, Poulogiannis G, Choo-Wing R, Wulf GM, Shim H, Lamia KA, Rameh LE, Yuan X, Bullock A, DeNicola GM, Song J, Signoretti S, Cantley LC. Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Ng05  0.679
2013 Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, ... Denicola GM, et al. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 155: 844-57. PMID 24209622 DOI: 10.1016/J.Cell.2013.09.057  0.716
2012 Gopinathan A, Denicola GM, Frese KK, Cook N, Karreth FA, Mayerle J, Lerch MM, Reinheckel T, Tuveson DA. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut. 61: 877-84. PMID 22157328 DOI: 10.1136/Gutjnl-2011-300850  0.523
2012 Caldwell ME, DeNicola GM, Martins CP, Jacobetz MA, Maitra A, Hruban RH, Tuveson DA. Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer. Oncogene. 31: 1599-608. PMID 21860420 DOI: 10.1038/Onc.2011.350  0.599
2011 Karreth FA, Frese KK, DeNicola GM, Baccarini M, Tuveson DA. C-Raf is required for the initiation of lung cancer by K-Ras(G12D). Cancer Discovery. 1: 128-36. PMID 22043453 DOI: 10.1158/2159-8290.Cd-10-0044  0.569
2011 Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, et al. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 147: 382-95. PMID 22000016 DOI: 10.1016/J.Cell.2011.09.032  0.605
2011 DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 475: 106-9. PMID 21734707 DOI: 10.1038/Nature10189  0.588
2011 Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. The Embo Journal. 30: 2719-33. PMID 21602788 DOI: 10.1038/Emboj.2011.158  0.38
2009 Karreth FA, DeNicola GM, Winter SP, Tuveson DA. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). Molecular Cell. 36: 477-86. PMID 19917255 DOI: 10.1016/J.Molcel.2009.10.017  0.545
2009 DeNicola GM, Tuveson DA. RAS in cellular transformation and senescence. European Journal of Cancer (Oxford, England : 1990). 45: 211-6. PMID 19775620 DOI: 10.1016/S0959-8049(09)70036-X  0.572
2009 Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (New York, N.Y.). 324: 1457-61. PMID 19460966 DOI: 10.1126/Science.1171362  0.569
2005 Denicola G, Tuveson DA. VAV1: a new target in pancreatic cancer? Cancer Biology & Therapy. 4: 509-11. PMID 15970675 DOI: 10.4161/Cbt.4.5.1781  0.618
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