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Adrian L Harris - Publications

Affiliations: 
Weatherall Institute of Molecular Medicine University of Oxford, Oxford, United Kingdom 
Area:
Breast cancer, angiogenesis, hypoxia, metabolism
Website:
https://www.oncology.ox.ac.uk/team/adrian-harris
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Year Citation  Score
2023 Pagnamenta AT, Camps C, Giacopuzzi E, Taylor JM, Hashim M, Calpena E, Kaisaki PJ, Hashimoto A, Yu J, Sanders E, Schwessinger R, Hughes JR, Lunter G, Dreau H, Ferla M, ... ... Harris AL, et al. Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases. Genome Medicine. 15: 94. PMID 37946251 DOI: 10.1186/s13073-023-01240-0  0.567
2023 Wang Z, Zhang N, Zhang M, Jiang Y, Ng AS, Bridges E, Zhang W, Zeng X, Luo Q, Liang J, Gyorffy B, Hublitz P, Liang Z, Fischer R, Kerr D, ... Harris AL, et al. GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner. Cancer Research. PMID 37463466 DOI: 10.1158/0008-5472.CAN-22-3471  0.349
2023 Lord SR, Harris AL. Is it still worth pursuing the repurposing of metformin as a cancer therapeutic? British Journal of Cancer. PMID 36823364 DOI: 10.1038/s41416-023-02204-2  0.64
2023 Yu T, Jadhav AC, Xu J, Harris AL, Nair V, Huang WE. Metabolic Reprogramming in Colon Cancer Cells Persistently Infected with Newcastle Disease Virus. Cancers. 15. PMID 36765769 DOI: 10.3390/cancers15030811  0.493
2022 Harris BHL, Macaulay VM, Harris DA, Klenerman P, Karpe F, Lord SR, Harris AL, Buffa FM. Obesity: a perfect storm for carcinogenesis. Cancer Metastasis Reviews. PMID 36038791 DOI: 10.1007/s10555-022-10046-2  0.711
2022 Badve SS, Cho S, Lu X, Cao S, Ghose S, Thike AA, Tan PH, Ocal IT, Generali D, Zanconati F, Harris AL, Ginty F, Gökmen-Polar Y. Tumor Infiltrating Lymphocytes in Multi-National Cohorts of Ductal Carcinoma In Situ (DCIS) of Breast. Cancers. 14. PMID 36010908 DOI: 10.3390/cancers14163916  0.503
2022 Zois CE, Hendriks AM, Haider S, Pires E, Bridges E, Kalamida D, Voukantsis D, Lagerholm BC, Fehrmann RSN, den Dunnen WFA, Tarasov AI, Baba O, Morris J, Buffa FM, McCullagh JSO, ... ... Harris AL, et al. Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation. Cell Death & Disease. 13: 573. PMID 35764612 DOI: 10.1038/s41419-022-05005-2  0.504
2022 Arnaiz E, Harris AL. Role of Hypoxia in the Interferon Response. Frontiers in Immunology. 13: 821816. PMID 35251003 DOI: 10.3389/fimmu.2022.821816  0.325
2022 Carroll CP, Bolland H, Vancauwenberghe E, Collier P, Ritchie AA, Clarke PA, Grabowska AM, Harris AL, McIntyre A. Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis. Neoplasia (New York, N.Y.). 25: 41-52. PMID 35150959 DOI: 10.1016/j.neo.2022.01.003  0.351
2022 Schilling K, Harris AL, Halliday AN, Schofield CJ, Sheldon H, Haider S, Larner F. Investigations on Zinc Isotope Fractionation in Breast Cancer Tissue Using Cell Culture Uptake-Efflux Experiments. Frontiers in Medicine. 8: 746532. PMID 35127740 DOI: 10.3389/fmed.2021.746532  0.517
2021 Sheldon H, Alexander J, Bridges E, Moreira L, Reilly S, Ang KH, Wang D, Lin S, Haider S, Banham AH, Harris AL. ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype. International Journal of Molecular Sciences. 22. PMID 34681953 DOI: 10.3390/ijms222011293  0.811
2021 Sheldon H, Bridges E, Silva I, Masiero M, Favara DM, Wang D, Leek R, Snell C, Roxanis I, Kreuzer M, Gileadi U, Buffa FM, Banham A, Harris AL. ADGRL4/ELTD1 expression in breast cancer cells induces vascular normalisation and immune suppression. Molecular Cancer Research : McR. PMID 34348993 DOI: 10.1158/1541-7786.MCR-21-0171  0.825
2021 Giatromanolaki A, Harris AL, Koukourakis MI. The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer. Cancer & Metabolism. 9: 28. PMID 34344457 DOI: 10.1186/s40170-021-00264-7  0.541
2021 Goedegebuure RSA, Kleibeuker EA, Buffa FM, Castricum KCM, Haider S, Schulkens IA, Ten Kroode L, van den Berg J, Jacobs MAJM, van Berkel AM, van Grieken NCT, Derks S, Slotman BJ, Verheul HMW, Harris AL, et al. Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation. Journal of Experimental & Clinical Cancer Research : Cr. 40: 161. PMID 33964942 DOI: 10.1186/s13046-021-01962-2  0.772
2021 Artibani M, Masuda K, Hu Z, Rauher PC, Mallett G, Wietek N, Morotti M, Chong K, KaramiNejadRanjbar M, Zois CE, Dhar S, El-Sahhar S, Campo L, Blagden SP, Damato S, ... ... Harris AL, et al. Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells. Jci Insight. PMID 33945502 DOI: 10.1172/jci.insight.147929  0.779
2021 Xu J, Yu T, Zois CE, Cheng JX, Tang Y, Harris AL, Huang WE. Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing. Cancers. 13. PMID 33916413 DOI: 10.3390/cancers13071718  0.446
2021 Favara DM, Liebscher I, Jazayeri A, Nambiar M, Sheldon H, Banham AH, Harris AL. Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling. Scientific Reports. 11: 8870. PMID 33893326 DOI: 10.1038/s41598-021-85408-x  0.755
2021 Fanfani V, Citi L, Harris AL, Pezzella F, Stracquadanio G. The landscape of the heritable cancer genome. Cancer Research. PMID 33731442 DOI: 10.1158/0008-5472.CAN-20-3348  0.543
2021 Skwarski M, McGowan DR, Belcher E, Di Chiara F, Stavroulias D, McCole MG, Derham J, Chu KY, Teoh E, Chauhan J, O'Reilly D, Harris BHL, Macklin PS, Bull JA, Green M, ... ... Harris AL, et al. Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33597271 DOI: 10.1158/1078-0432.CCR-20-4128  0.593
2020 Baird RD, Linossi C, Middleton M, Lord S, Harris A, Rodón J, Zitt C, Fiedler U, Dawson KM, Leupin N, Stumpp MT, Harstrick A, Azaro A, Fischer S, Omlin A. First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2000596. PMID 33301375 DOI: 10.1200/JCO.20.00596  0.659
2020 Morotti M, Zois CE, El-Ansari R, Craze ML, Rakha EA, Fan SJ, Valli A, Haider S, Goberdhan DCI, Green AR, Harris AL. Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. British Journal of Cancer. PMID 33028955 DOI: 10.1038/s41416-020-01113-y  0.819
2020 de Heer EC, Jalving M, Harris AL. HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer. The Journal of Clinical Investigation. PMID 32870818 DOI: 10.1172/JCI137552  0.335
2020 Kawashima M, Bensaad K, Zois CE, Barberis A, Bridges E, Wigfield S, Lagerholm C, Dmitriev RI, Tokiwa M, Toi M, Papkovsky DB, Buffa FM, Harris AL. Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells. Cancer & Metabolism. 8: 18. PMID 32789015 DOI: 10.1186/s40170-020-00224-7  0.767
2020 Walsh CA, Akrap N, Garre E, Magnusson Y, Harrison H, Andersson D, Jonasson E, Rafnsdottir S, Choudhry H, Buffa F, Ragoussis J, Ståhlberg A, Harris A, Landberg G. The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer. Plos One. 15: e0236187. PMID 32692762 DOI: 10.1371/journal.pone.0236187  0.622
2020 Kawashima M, Bensaad K, Zois CE, Barberis A, Bridges E, Wigfield S, Lagerholm C, Dmitriev RI, Tokiwa M, Toi M, Papkovsky DB, Buffa FM, Harris AL. Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells. Cancer & Metabolism. 8: 13. PMID 32647572 DOI: 10.1186/S40170-020-00219-4  0.778
2020 Dhawan A, Scott J, Sundaresan P, Veness M, Porceddu S, Hau E, Harris AL, Buffa FM, Gee HE. Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer. Scientific Reports. 10: 10226. PMID 32576885 DOI: 10.1038/S41598-020-66983-X  0.684
2020 Fanfani V, Zatopkova M, Harris AL, Pezzella F, Stracquadanio G. Dissecting the heritable risk of breast cancer: from statistical methods to susceptibility genes. Seminars in Cancer Biology. PMID 32569822 DOI: 10.1016/j.semcancer.2020.06.001  0.557
2020 Bridges E, Sheldon H, Kleibeuker E, Ramberger E, Zois C, Barnard A, Harjes U, Li JL, Masiero M, MacLaren R, Harris A. RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain. Angiogenesis. PMID 32506201 DOI: 10.1007/S10456-020-09726-W  0.795
2020 Giatromanolaki A, Harris AL, Banham AH, Contrafouris CA, Koukourakis MI. Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration. British Journal of Cancer. PMID 32066909 DOI: 10.1038/s41416-020-0756-3  0.454
2019 Lord SR, Collins JM, Cheng WC, Haider S, Wigfield S, Gaude E, Fielding BA, Pinnick KE, Harjes U, Segaran A, Jha P, Hoefler G, Pollak MN, Thompson AM, Roy PG, ... ... Harris AL, et al. Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin. British Journal of Cancer. PMID 31819193 DOI: 10.1038/s41416-019-0665-5  0.802
2019 Kawashima M, Tokiwa M, Nishimura T, Kawata Y, Sugimoto M, Kataoka TR, Sakurai T, Iwaisako K, Suzuki E, Hagiwara M, Harris AL, Toi M. High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. British Journal of Cancer. PMID 31819188 DOI: 10.1038/s41416-019-0662-8  0.449
2019 Favara DM, Zois CE, Haider S, Pires E, Sheldon H, McCullagh J, Banham AH, Harris AL. ADGRL4/ELTD1 Silencing in Endothelial Cells Induces ACLY and SLC25A1 and Alters the Cellular Metabolic Profile. Metabolites. 9. PMID 31775252 DOI: 10.3390/metabo9120287  0.801
2019 Masiero M, Li D, Whiteman P, Bentley C, Greig J, Hassanali T, Watts S, Stribbling S, Yates J, Bealing E, Li JL, Chillakuri C, Sheppard D, Serres S, Sarmiento-Soto M, ... ... Harris AL, et al. Development of therapeutic anti-JAGGED1 antibodies for cancer therapy. Molecular Cancer Therapeutics. PMID 31395687 DOI: 10.1158/1535-7163.Mct-18-1176  0.683
2019 Giatromanolaki A, Koukourakis IM, Balaska K, Mitrakas AG, Harris AL, Koukourakis MI. Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis. Medical Oncology (Northwood, London, England). 36: 76. PMID 31342270 DOI: 10.1007/s12032-019-1299-4  0.424
2019 Fox NS, Haider S, Harris AL, Boutros PC. Landscape of transcriptomic interactions between breast cancer and its microenvironment. Nature Communications. 10: 3116. PMID 31308365 DOI: 10.1038/s41467-019-10929-z  0.517
2019 Favara DM, Banham AH, Harris AL. ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants. Bmc Evolutionary Biology. 19: 143. PMID 31299890 DOI: 10.1186/s12862-019-1445-9  0.746
2019 Morotti M, Bridges E, Valli A, Choudhry H, Sheldon H, Wigfield S, Gray N, Zois CE, Grimm F, Jones D, Teoh EJ, Cheng WC, Lord S, Anastasiou D, Haider S, ... ... Harris AL, et al. Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31152137 DOI: 10.1073/Pnas.1818521116  0.83
2019 Giatromanolaki A, Banham AH, Harris AL, Koukourakis MI. FOXP3 infiltrating lymphocyte density and PD-L1 expression in operable non-small cell lung carcinoma. Experimental Lung Research. 1-8. PMID 31134811 DOI: 10.1080/01902148.2019.1617371  0.482
2019 Valli A, Morotti M, Zois CE, Albers PK, Soga T, Feldinger K, Fischer R, Frejno M, McIntyre A, Bridges E, Haider S, Buffa FM, Baban D, Rodriguez M, Yanes O, ... ... Harris AL, et al. Adaptation to HIF1α deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism. Molecular Cancer Research : McR. PMID 30885992 DOI: 10.1158/1541-7786.MCR-18-0315  0.812
2018 Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO, Harris AL. 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. Molecular Cancer Therapeutics. 18: 376-388. PMID 30478149 DOI: 10.1158/1535-7163.MCT-17-0857  0.795
2018 Lord SR, Cheng WC, Liu D, Gaude E, Haider S, Metcalf T, Patel N, Teoh EJ, Gleeson F, Bradley K, Wigfield S, Zois C, McGowan DR, Ah-See ML, Thompson AM, ... ... Harris AL, et al. Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism. PMID 30244975 DOI: 10.1016/J.Cmet.2018.08.021  0.812
2018 Lee SH, McIntyre D, Honess D, Hulikova A, Pacheco-Torres J, Cerdán S, Swietach P, Harris AL, Griffiths JR. Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo. British Journal of Cancer. PMID 30206370 DOI: 10.1038/S41416-018-0216-5  0.58
2018 Leithner K, Triebl A, Trötzmüller M, Hinteregger B, Leko P, Wieser BI, Grasmann G, Bertsch AL, Züllig T, Stacher E, Valli A, Prassl R, Olschewski A, Harris AL, Köfeler HC, et al. The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844165 DOI: 10.1073/pnas.1719871115  0.716
2018 Schuh A, Dreau H, Knight SJL, Ridout K, Mizani T, Vavoulis D, Colling R, Antoniou P, Kvikstad EM, Pentony MM, Hamblin A, Protheroe A, Parton M, Shah KA, Orosz Z, ... ... Harris A, et al. Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing. Cold Spring Harbor Molecular Case Studies. 4. PMID 29610388 DOI: 10.1101/mcs.a002279  0.57
2018 Donnem T, Reynolds AR, Kuczynski EA, Gatter K, Vermeulen PB, Kerbel RS, Harris AL, Pezzella F. Non-angiogenic tumours and their influence on cancer biology. Nature Reviews. Cancer. PMID 29520090 DOI: 10.1038/Nrc.2018.14  0.554
2018 Woodcock VK, Clive S, Wilson RH, Coyle VM, Stratford MRL, Folkes LK, Eastell R, Barton C, Jones P, Kazmi-Stokes S, Turner H, Halford S, Harris AL, Middleton MR. A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424. British Journal of Cancer. PMID 29438361 DOI: 10.1038/bjc.2017.484  0.536
2018 Koukourakis MI, Giatromanolaki A, Fylaktakidou K, Sivridis E, Zois CE, Kalamida D, Mitrakas A, Pouliliou S, Karagounis IV, Simopoulos K, Ferguson DJP, Harris AL. SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone morrow and liver against radiotherapy. Investigational New Drugs. PMID 29387992 DOI: 10.1007/s10637-018-0566-0  0.459
2018 Yang J, Harris AL, Davidoff AM. Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer. International Journal of Molecular Sciences. 19. PMID 29342868 DOI: 10.3390/ijms19010240  0.379
2018 Koukourakis MI, Giatromanolaki A, Fylaktakidou K, Kouroupi M, Sivridis E, Zois CE, Kalamida D, Mitrakas A, Pouliliou S, Karagounis IV, Simopoulos K, Ferguson DJP, Harris AL. Amifostine Protects Mouse Liver Against Radiation-induced Autophagy Blockage. Anticancer Research. 38: 227-238. PMID 29277777 DOI: 10.21873/anticanres.12212  0.415
2018 Dhawan A, Scott JG, Sundaresan P, Veness M, Porceddu S, Hau E, Ahern V, Harris AL, Buffa FM, Gee HE. Are signatures of radiosensitivity ready for routine clinical use? A pragmatic comparison of clinical, pathological, and gene signature predictors of outcome in oropharynx head and neck cancers. Journal of Clinical Oncology. 36: e18046-e18046. DOI: 10.1016/J.Ijrobp.2018.06.338  0.68
2018 Dhawan A, Scott J, Sundaresan P, Veness M, Porceddu S, Hau E, Ahern V, Harris A, Buffa F, Gee H. Are Signatures of Radiosensitivity Ready for Routine Clinical Use? a Pragmatic Comparison of Clinical, Pathological and Gene Signature Predictors of Outcome in Oropharynx Head and Neck Cancers International Journal of Radiation Oncology*Biology*Physics. 102: S137-S138. DOI: 10.1016/j.ijrobp.2018.06.338  0.68
2017 Pajic M, Froio D, Daly S, Doculara L, Millar E, Graham PH, Drury A, Steinmann A, de Bock CE, Boulghourjian A, Zaratzian A, Carroll S, Toohey J, O'Toole SA, Harris AL, et al. miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense. Cancer Research. PMID 29180477 DOI: 10.1158/0008-5472.CAN-16-3105  0.712
2017 Choudhry H, Harris AL. Advances in Hypoxia-Inducible Factor Biology. Cell Metabolism. PMID 29129785 DOI: 10.1016/j.cmet.2017.10.005  0.607
2017 Milani M, Venturini S, Bonardi S, Allevi G, Strina C, Cappelletti MR, Corona SP, Aguggini S, Bottini A, Berruti A, Jubb A, Campo L, Harris AL, Gatter K, Fox SB, et al. Hypoxia-related biological markers as predictors of epirubicin-based treatment responsiveness and resistance in locally advanced breast cancer. Oncotarget. 8: 78870-78881. PMID 29108271 DOI: 10.18632/oncotarget.20239  0.81
2017 Morotti M, Dass PH, Harris AL, Lord S. Pharmacodynamic and Pharmacokinetic Markers For Anti-angiogenic Cancer Therapy: Implications for Dosing and Selection of Patients. European Journal of Drug Metabolism and Pharmacokinetics. PMID 29019020 DOI: 10.1007/s13318-017-0442-x  0.803
2017 Oon CE, Bridges E, Sheldon H, Sainson RCA, Jubb A, Turley H, Leek R, Buffa F, Harris AL, Li JL. Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth. Oncotarget. PMID 28445154 DOI: 10.18632/oncotarget.16969  0.81
2017 Erdal E, Haider S, Rehwinkel J, Harris AL, McHugh PJ. A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1. Genes & Development. PMID 28279982 DOI: 10.1101/gad.289769.116  0.805
2017 Cheng W, Choudhry H, Leszczynska K, Roberts D, Hammond E, West C, Harris A, Buffa F. Extensive global alternative splicing induced by hypoxia across four major cancer types Annals of Oncology. 28: vii25. DOI: 10.1093/annonc/mdx513  0.58
2016 Kleibeuker EA, Fokas E, Allen PD, Kersemans V, Griffioen AW, Beech J, Im JH, Smart SC, Castricum KC, van den Berg J, Schulkens IA, Hill SA, Harris AL, Slotman BJ, Verheul HM, et al. Low dose angiostatic treatment counteracts radiotherapy-induced tumor perfusion and enhances the anti-tumor effect. Oncotarget. PMID 27780936 DOI: 10.18632/oncotarget.12814  0.801
2016 Koukourakis MI, Giatromanolaki A, Zois CE, Kalamida D, Pouliliou S, Karagounis IV, Yeh TL, Abboud MI, Claridge TD, Schofield CJ, Sivridis E, Simopoulos C, Tokmakidis SP, Harris AL. Normal tissue radioprotection by amifostine via Warburg-type effects. Scientific Reports. 6: 30986. PMID 27507219 DOI: 10.1038/Srep30986  0.5
2016 Mehta S, Hughes NP, Li S, Jubb A, Adams R, Lord S, Koumakis L, van Stiphout R, Padhani A, Makris A, Buffa FM, Harris AL. Radiogenomics Monitoring in Breast Cancer Identifies Metabolism and Immune Checkpoints as Early Actionable Mechanisms of Resistance to Anti-angiogenic Treatment. Ebiomedicine. PMID 27474395 DOI: 10.1016/j.ebiom.2016.07.017  0.822
2016 Andreis D, Bonardi S, Allevi G, Aguggini S, Gussago F, Milani M, Strina C, Spada D, Ferrero G, Ungari M, Rocca A, Nanni O, Roviello G, Berruti A, Harris AL, et al. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with T2 to T4, N0 and N1 breast cancer. Breast (Edinburgh, Scotland). 29: 55-61. PMID 27428471 DOI: 10.1016/j.breast.2016.07.003  0.737
2016 Haider S, McIntyre A, van Stiphout RG, Winchester LM, Wigfield S, Harris AL, Buffa FM. Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. Genome Biology. 17: 140. PMID 27358048 DOI: 10.1186/s13059-016-0999-8  0.792
2016 Leek R, Grimes DR, Harris AL, McIntyre A. Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia. Advances in Experimental Medicine and Biology. 899: 167-96. PMID 27325267 DOI: 10.1007/978-3-319-26666-4_10  0.583
2016 da Motta LL, Ledaki I, Purshouse K, Haider S, De Bastiani MA, Baban D, Morotti M, Steers G, Wigfield S, Bridges E, Li JL, Knapp S, Ebner D, Klamt F, Harris AL, et al. The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer. Oncogene. PMID 27292261 DOI: 10.1038/onc.2016.184  0.835
2016 McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li JL, Russell A, Swietach P, Harris AL. Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth. Cancer Research. PMID 27197160 DOI: 10.1158/0008-5472.Can-15-1862  0.821
2016 Grimes DR, Kannan P, McIntyre A, Kavanagh A, Siddiky A, Wigfield S, Harris A, Partridge M. The Role of Oxygen in Avascular Tumor Growth. Plos One. 11: e0153692. PMID 27088720 DOI: 10.1371/journal.pone.0153692  0.713
2016 Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, ... ... Harris AL, et al. Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer & Metabolism. 4: 6. PMID 27042297 DOI: 10.1186/S40170-016-0146-8  0.627
2016 Lord S, Funes JM, Harris AL, Quintela-Fandino M. Antiangiogenic resistance and cancer metabolism: opportunities for synthetic lethality. Current Drug Targets. PMID 26953245 DOI: 10.2174/1389450117666160307143718  0.674
2016 Gijsen M, King P, Perera T, Parker PJ, Harris AL, Larijani B, Kong A. Correction: HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer. Plos Biology. 14: e1002414. PMID 26949965 DOI: 10.1371/journal.pbio.1002414  0.596
2016 Siriwardana PN, Luong TV, Watkins J, Turley H, Ghazaley M, Gatter K, Harris AL, Hochhauser D, Davidson BR. Biological and Prognostic Significance of the Morphological Types and Vascular Patterns in Colorectal Liver Metastases (CRLM): Looking Beyond the Tumor Margin. Medicine. 95: e2924. PMID 26937938 DOI: 10.1097/MD.0000000000002924  0.618
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Harris AL, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.362
2016 Adighibe O, Leek RD, Fernandez-Mercado M, Hu J, Snell C, Gatter KC, Harris AL, Pezzella F. Why some tumours trigger neovascularisation and others don't: the story thus far. Chinese Journal of Cancer. 35: 18. PMID 26873439 DOI: 10.1186/s40880-016-0082-6  0.814
2016 Chen L, Zeng X, Kleibeuker E, Buffa F, Barberis A, Leek RD, Roxanis I, Zhang W, Worth A, Beech JS, Harris AL, Cai S. Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth. Oncotarget. PMID 26814432 DOI: 10.18632/oncotarget.6981  0.834
2016 Choudhry H, Harris AL, McIntyre A. The tumour hypoxia induced non-coding transcriptome. Molecular Aspects of Medicine. PMID 26806607 DOI: 10.1016/j.mam.2016.01.003  0.578
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Harris AL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.422
2016 Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Schödel J, Green C, Camps C, Buffa F, Ratcliffe P, Ragoussis I, Mole D, Harris A. Abstract A29: Hypoxia regulated long noncoding RNAs and antisense transcripts in breast cancer: Novel insights of noncoding transcriptional regulation in hypoxic microenvironment Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-A29  0.826
2016 Siriwardana P, Luong T, Watkins J, Turley H, Ong W, Gatter K, Hochhauser D, Harris A, Davidson B. Ten-year follow up case-control study of the effect of portal vein embolisation on the survival of patients with colorectal liver metastases; the hypoxia factor influence Hpb. 18: e3. DOI: 10.1016/J.HPB.2016.02.014  0.529
2016 Lord S, Liu D, Cheng W, Haider S, Gaude E, Teoh E, Patel N, Metcalf T, McGowan D, Roxanis I, Qifeng Z, Roy P, Gleeson F, Thompson A, Pollak M, ... ... Harris A, et al. Metformin increases 18F-FDG flux and inhibits fatty acid oxidation at clinical doses in breast cancer: Results of a phase 0 clinical trial European Journal of Surgical Oncology (Ejso). 42: S230. DOI: 10.1016/J.Ejso.2016.07.060  0.698
2015 Pezzella F, Harris AL, Tavassoli M, Gatter KC. Blood vessels and cancer much more than just angiogenesis. Cell Death Discovery. 1: 15064. PMID 27551488 DOI: 10.1038/cddiscovery.2015.64  0.549
2015 Zhang X, Gee H, Rose B, Lee CS, Clark J, Elliott M, Gamble JR, Cairns MJ, Harris A, Khoury S, Tran N. Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers. Bmc Cancer. 16: 86. PMID 26867589 DOI: 10.1186/s12885-016-2109-4  0.707
2015 Biziota E, Briasoulis E, Mavroeidis L, Marselos M, Harris AL, Pappas P. Cellular and molecular effects of metronomic vinorelbine and 4-O-deacetylvinorelbine on human umbilical vein endothelial cells. Anti-Cancer Drugs. PMID 26629767 DOI: 10.1097/CAD.0000000000000319  0.805
2015 Yang J, AlTahan A, Jones DT, Buffa FM, Bridges E, Interiano RB, Qu C, Vogt N, Li JL, Baban D, Ragoussis J, Nicholson R, Davidoff AM, Harris AL. Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 26598706 DOI: 10.1073/pnas.1422015112  0.768
2015 Gee HE, Buffa FM, Harris AL, Toohey JM, Carroll SL, Cooper CL, Beith J, McNeil C, Carmalt H, Mak C, Warrier S, Holliday A, Selinger C, Beckers R, Kennedy C, et al. MicroRNA-Related DNA Repair/Cell-Cycle Genes Independently Associated With Relapse After Radiation Therapy for Early Breast Cancer. International Journal of Radiation Oncology, Biology, Physics. 93: 1104-14. PMID 26581147 DOI: 10.1016/j.ijrobp.2015.08.046  0.721
2015 Fan SJ, Snell C, Turley H, Li JL, McCormick R, Perera SM, Heublein S, Kazi S, Azad A, Wilson C, Harris AL, Goberdhan DC. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. PMID 26434594 DOI: 10.1038/onc.2015.363  0.605
2015 Koukourakis MI, Kalamida D, Giatromanolaki A, Zois CE, Sivridis E, Pouliliou S, Mitrakas A, Gatter KC, Harris AL. Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines. Plos One. 10: e0137675. PMID 26378792 DOI: 10.1371/journal.pone.0137675  0.471
2015 Ledaki I, McIntyre A, Wigfield S, Buffa F, McGowan S, Baban D, Li JL, Harris AL. Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition. Oncotarget. 6: 19413-27. PMID 26305601  0.82
2015 Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, Schödel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, Mole DR. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 34: 4546. PMID 26289678 DOI: 10.1038/onc.2014.431  0.815
2015 Giatromanolaki A, Kalamida D, Sivridis E, Karagounis IV, Gatter KC, Harris AL, Koukourakis MI. Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 90: 98-105. PMID 26264650 DOI: 10.1016/j.lungcan.2015.07.008  0.487
2015 Blick C, Ramachandran A, McCormick R, Wigfield S, Cranston D, Catto J, Harris AL. Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis. British Journal of Cancer. 113: 634-44. PMID 26196183 DOI: 10.1038/bjc.2015.203  0.797
2015 Valli A, Harris AL, Kessler BM. Hypoxia metabolism in ageing. Aging. 7: 465-6. PMID 26187134  0.661
2015 Amoroso V, Generali D, Buchholz T, Cristofanilli M, Pedersini R, Curigliano G, Daidone MG, Di Cosimo S, Dowsett M, Fox S, Harris AL, Makris A, Vassalli L, Ravelli A, Cappelletti MR, et al. International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fifth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2013). Journal of the National Cancer Institute. Monographs. 2015: 90-6. PMID 26063896 DOI: 10.1093/jncimonographs/lgv023  0.604
2015 Lord SR, Patel N, Liu D, Fenwick J, Gleeson F, Buffa F, Harris AL. Neoadjuvant Window Studies of Metformin and Biomarker Development for Drugs Targeting Cancer Metabolism. Journal of the National Cancer Institute. Monographs. 2015: 81-6. PMID 26063894 DOI: 10.1093/jncimonographs/lgv011  0.662
2015 Generali D, Berruti A, Cappelletti MR, Zanotti L, Brugnoli G, Forti M, Bedussi F, Vailati ME, Milani M, Strina C, Ardine M, Aguggini S, Allevi G, Ferrero G, Bertoni R, ... ... Harris AL, et al. Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1α and Relation to Clinical Response. Journal of the National Cancer Institute. Monographs. 2015: 64-6. PMID 26063890 DOI: 10.1093/jncimonographs/lgv018  0.796
2015 Chiorean EG, LoRusso P, Strother RM, Diamond JR, Younger A, Messersmith WA, Adriaens L, Liu L, Kao RJ, DiCioccio AT, Kostic A, Leek R, Harris A, Jimeno A. A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2695-703. PMID 25724527 DOI: 10.1158/1078-0432.Ccr-14-2797  0.582
2015 McIntyre A, Harris AL. Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality. Embo Molecular Medicine. 7: 368-79. PMID 25700172 DOI: 10.15252/emmm.201404271  0.302
2015 Leung WY, Roxanis I, Sheldon H, Buffa FM, Li JL, Harris AL, Kong A. Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer. Oncotarget. 6: 5678-94. PMID 25691057  0.772
2015 Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, Harris AL, Schulze A. SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene. PMID 25619842 DOI: 10.1038/onc.2014.439  0.302
2015 Valli A, Rodriguez M, Moutsianas L, Fischer R, Fedele V, Huang HL, Van Stiphout R, Jones D, Mccarthy M, Vinaxia M, Igarashi K, Sato M, Soga T, Buffa F, Mccullagh J, ... ... Harris A, et al. Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways. Oncotarget. 6: 1920-41. PMID 25605240 DOI: 10.18632/Oncotarget.3058  0.793
2015 Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, ... ... Harris AL, et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell. 27: 57-71. PMID 25584894 DOI: 10.1016/J.Ccell.2014.12.002  0.634
2015 Fleming IN, Manavaki R, Blower PJ, West C, Williams KJ, Harris AL, Domarkas J, Lord S, Baldry C, Gilbert FJ. Imaging tumour hypoxia with positron emission tomography. British Journal of Cancer. 112: 238-50. PMID 25514380 DOI: 10.1038/bjc.2014.610  0.625
2015 Bazzola L, Foroni C, Andreis D, Zanoni V, R Cappelletti M, Allevi G, Aguggini S, Strina C, Milani M, Venturini S, Ferrozzi F, Giardini R, Bertoni R, Turley H, Gatter K, ... ... Harris AL, et al. Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer. British Journal of Cancer. 112: 52-60. PMID 25461806 DOI: 10.1038/bjc.2014.563  0.811
2015 Harris BHL, Wigfield S, Harris AL, Buffa FM. Bioinformatic approaches elucidate a high likelyhood of interaction between miR-182 and the pro-apoptotic gene MTCH2 in breast cancers. Journal of Clinical Oncology. 33: e12551-e12551. DOI: 10.1200/jco.2015.33.15_suppl.e12551  0.714
2015 Choudhry H, Schodel J, Albukhari A, Haider S, Buffa F, Ratcliffe PJ, Mole DR, Ragousis I, Harris AL. Abstract P2-05-01: The non-coding transcriptome of hypoxic breast cancer: Novel insights of clinical relevant long non-coding RNA in hypoxia signalling Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P2-05-01  0.707
2015 Stevens D, Verrill C, Bryant R, McKee C, Turley H, Fan S, Perera S, Wilson C, Harris AL, Hamdy FC, Goberdhan DC. MP55-12 THE PROTON-ASSISTED AMINO ACID TRANSPORTER 4 (PAT4/SLC36A4) IS UP-REGULATED IN PROSTATE CANCER Journal of Urology. 193. DOI: 10.1016/J.Juro.2015.02.2055  0.572
2014 Kato T, Pezzella F, Steers G, Campo L, Leek RD, Turley H, Kameoka S, Nishikawa T, Harris AL, Gatter KC, Fox S. Blood vessel invasion and other variables as predictors of long-term survival in Japanese and British patients with primary invasive breast cancer. International Journal of Clinical and Experimental Pathology. 7: 7967-78. PMID 25550840  0.807
2014 Singleton DC, Rouhi P, Zois CE, Haider S, Li JL, Kessler BM, Cao Y, Harris AL. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene. PMID 25486436 DOI: 10.1038/onc.2014.396  0.819
2014 Giatromanolaki A, Sivridis E, Mitrakas A, Kalamida D, Zois CE, Haider S, Piperidou C, Pappa A, Gatter KC, Harris AL, Koukourakis MI. Autophagy and lysosomal related protein expression patterns in human glioblastoma. Cancer Biology & Therapy. 15: 1468-78. PMID 25482944 DOI: 10.4161/15384047.2014.955719  0.641
2014 Choudhry H, Albukhari A, Morotti M, Hider S, Moralli D, Smythies J, Schödel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, Mole DR. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. PMID 25417700 DOI: 10.1038/Onc.2014.378  0.836
2014 Favara DM, Banham AH, Harris AL. A review of ELTD1, a pro-angiogenic adhesion GPCR. Biochemical Society Transactions. 42: 1658-64. PMID 25399586 DOI: 10.1042/BST20140216  0.768
2014 van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MH, Yao CQ, Ivan M, Ivan C, Pecot CV, et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nature Communications. 5: 5203. PMID 25351418 DOI: 10.1038/Ncomms6203  0.556
2014 Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, ... ... Harris AL, et al. Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-33. PMID 25347767 DOI: 10.3109/14756366.2014.966704  0.805
2014 Li D, Masiero M, Banham AH, Harris AL. The notch ligand JAGGED1 as a target for anti-tumor therapy. Frontiers in Oncology. 4: 254. PMID 25309874 DOI: 10.3389/fonc.2014.00254  0.321
2014 Adighibe O, Turley H, Leek R, Harris A, Coutts AS, La Thangue N, Gatter K, Pezzella F. JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues. Virchows Archiv : An International Journal of Pathology. 465: 715-22. PMID 25280461 DOI: 10.1007/s00428-014-1660-0  0.803
2014 Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJ, Karpe F, Schulze A, Harris AL. Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. Cell Reports. 9: 349-65. PMID 25263561 DOI: 10.1016/j.celrep.2014.08.056  0.797
2014 Zois CE, Favaro E, Harris AL. Glycogen metabolism in cancer. Biochemical Pharmacology. 92: 3-11. PMID 25219323 DOI: 10.1016/j.bcp.2014.09.001  0.741
2014 Mohd Nafi SN, Generali D, Kramer-Marek G, Gijsen M, Strina C, Cappelletti M, Andreis D, Haider S, Li JL, Bridges E, Capala J, Ioannis R, Harris AL, Kong A. Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer. Oncotarget. 5: 5934-49. PMID 25153719  0.816
2014 Hulikova A, Aveyard N, Harris AL, Vaughan-Jones RD, Swietach P. Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure. The Journal of Biological Chemistry. 289: 25418-30. PMID 25059669 DOI: 10.1074/jbc.M114.547844  0.619
2014 Feldinger K, Generali D, Kramer-Marek G, Gijsen M, Ng TB, Wong JH, Strina C, Cappelletti M, Andreis D, Li JL, Bridges E, Turley H, Leek R, Roxanis I, Capala J, ... ... Harris AL, et al. ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer. Oncotarget. 5: 6633-46. PMID 24952873  0.815
2014 Harjes U, Bridges E, McIntyre A, Fielding BA, Harris AL. Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells. The Journal of Biological Chemistry. 289: 23168-76. PMID 24939870 DOI: 10.1074/jbc.M114.576512  0.655
2014 Generali D, Buffa FM, Deb S, Cummings M, Reid LE, Taylor M, Andreis D, Allevi G, Ferrero G, Byrne D, Martinotti M, Bottini A, Harris AL, Lakhani SR, Fox SB. COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment. British Journal of Cancer. 111: 46-54. PMID 24874483 DOI: 10.1038/bjc.2014.236  0.609
2014 Pezzella F, Harris AL. When cancer co-opts the vasculature. The New England Journal of Medicine. 370: 2146-7. PMID 24869725 DOI: 10.1056/NEJMcibr1402407  0.552
2014 Favara DM, Harris AL. VEGF sticky-trap: the first report of a non-systemically acting angiogenesis inhibitor. Embo Molecular Medicine. 6: 577-9. PMID 24803395 DOI: 10.1002/emmm.201404026  0.736
2014 Koukourakis MI, Giatromanolaki A, Bottini A, Cappelletti MR, Zanotti L, Allevi G, Strina C, Ardine M, Milani M, Brugnoli G, Martinotti M, Ferrero G, Bertoni R, Ferrozzi F, Harris AL, et al. Prospective neoadjuvant analysis of PET imaging and mechanisms of resistance to Trastuzumab shows role of HIF1 and autophagy. British Journal of Cancer. 110: 2209-16. PMID 24722179 DOI: 10.1038/bjc.2014.196  0.797
2014 Interiano RB, Yang J, Harris AL, Davidoff AM. Seven In Absentia Homolog 2 (SIAH2) downregulation is associated with tamoxifen resistance in MCF-7 breast cancer cells. The Journal of Surgical Research. 190: 203-9. PMID 24656476 DOI: 10.1016/j.jss.2014.02.018  0.373
2014 Agorreta J, Hu J, Liu D, Delia D, Turley H, Ferguson DJ, Iborra F, Pajares MJ, Larrayoz M, Zudaire I, Pio R, Montuenga LM, Harris AL, Gatter K, Pezzella F. TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC. Molecular Cancer Research : McR. 12: 660-9. PMID 24567527 DOI: 10.1158/1541-7786.MCR-13-0481  0.693
2014 Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F. Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. Plos One. 9: e88955. PMID 24563687 DOI: 10.1371/Journal.Pone.0088955  0.836
2014 Jiang H, Favaro E, Goulbourne CN, Rakowska PD, Hughes GM, Ryadnov MG, Fong LG, Young SG, Ferguson DJ, Harris AL, Grovenor CR. Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques. Methods (San Diego, Calif.). 68: 317-24. PMID 24556558 DOI: 10.1016/j.ymeth.2014.02.012  0.703
2014 Camps C, Saini HK, Mole DR, Choudhry H, Reczko M, Guerra-Assunção JA, Tian YM, Buffa FM, Harris AL, Hatzigeorgiou AG, Enright AJ, Ragoussis J. Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia. Molecular Cancer. 13: 28. PMID 24517586 DOI: 10.1186/1476-4598-13-28  0.583
2014 Swietach P, Vaughan-Jones RD, Harris AL, Hulikova A. The chemistry, physiology and pathology of pH in cancer. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130099. PMID 24493747 DOI: 10.1098/rstb.2013.0099  0.591
2014 Airley RE, McHugh P, Evans AR, Harris B, Winchester L, Buffa FM, Al-Tameemi W, Leek R, Harris AL. Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression. British Journal of Cancer. 110: 715-23. PMID 24366300 DOI: 10.1038/bjc.2013.765  0.81
2014 Choudhry H, Schödel J, Oikonomopoulos S, Camps C, Grampp S, Harris AL, Ratcliffe PJ, Ragoussis J, Mole DR. Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. Embo Reports. 15: 70-6. PMID 24363272 DOI: 10.1002/Embr.201337642  0.533
2014 Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F. Expression of proline-hydroxylated HIF-1α predicts poorer overall survival in primary breast cancer. Plos One. DOI: 10.1371/Journal.Pone.0088955.G005  0.814
2014 Choudhry H, Schodel J, Albukhari A, Oikonomopoulos S, Haider S, Buffa F, Ragousis I, Mole DR, Harris AL. Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer Bmc Genomics. 15. DOI: 10.1186/1471-2164-15-S2-P40  0.672
2014 Choudhry H, Schodel J, Albukhari A, Oikonomopoulos S, Haider S, Buffa F, Ragousis I, Mole DR, Harris AL. Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer Bmc Genomics. 15. DOI: 10.1186/1471-2164-15-S2-O17  0.691
2014 Choudhry H, Schodel J, Albukhari A, Oikonomopoulos S, Haider S, Moralli D, Camps C, Buffa F, Ratcliffe P, Ragousis I, Mole DR, Harris AL. Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer Bmc Genomics. 15. DOI: 10.1186/1471-2164-15-S2-O17  0.672
2014 Oon CE, Bridges E, Sheldon H, Sainson RCA, Jubb A, Turley H, Leek R, Buffa F, Li JL, Harris AL. Functional comparison of Notch ligands in tumour angiogenesis Asian Pacific Journal of Tropical Disease. 4: 229. DOI: 10.1016/S2222-1808(14)60523-5  0.779
2014 Jiang H, Favaro E, Goulbourne CN, Ferguson DJ, Young SG, Harris AL, Grovenor CR. Quantitatively Imaging Stable Isotopes at Subcellular Level with Correlative Electron Microscopy and Nanosims Analysis Biophysical Journal. 106: 597a-598a. DOI: 10.1016/J.BPJ.2013.11.3309  0.685
2013 Donnem T, Hu J, Ferguson M, Adighibe O, Snell C, Harris AL, Gatter KC, Pezzella F. Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment? Cancer Medicine. 2: 427-36. PMID 24156015 DOI: 10.1002/cam4.105  0.753
2013 Horsley L, Cummings J, Middleton M, Ward T, Backen A, Clamp A, Dawson M, Farmer H, Fisher N, Halbert G, Halford S, Harris A, Hasan J, Hogg P, Kumaran G, et al. A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours. Cancer Chemotherapy and Pharmacology. 72: 1343-52. PMID 24141375 DOI: 10.1007/s00280-013-2320-9  0.665
2013 Nikitenko LL, Leek R, Henderson S, Pillay N, Turley H, Generali D, Gunningham S, Morrin HR, Pellagatti A, Rees MC, Harris AL, Fox SB. The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5740-8. PMID 23969937 DOI: 10.1158/1078-0432.CCR-13-1712  0.811
2013 Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman JB, Mortensen N, ... ... Harris AL, et al. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell. 24: 229-41. PMID 23871637 DOI: 10.1016/J.Ccr.2013.06.004  0.811
2013 Bazan-Peregrino M, Sainson RC, Carlisle RC, Thoma C, Waters RA, Arvanitis C, Harris AL, Hernandez-Alcoceba R, Seymour LW. Combining virotherapy and angiotherapy for the treatment of breast cancer. Cancer Gene Therapy. 20: 461-8. PMID 23846253 DOI: 10.1038/Cgt.2013.41  0.74
2013 Blick C, Ramachandran A, Wigfield S, McCormick R, Jubb A, Buffa FM, Turley H, Knowles MA, Cranston D, Catto J, Harris AL. Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer. British Journal of Cancer. 109: 50-9. PMID 23778527 DOI: 10.1038/bjc.2013.240  0.801
2013 Eustace A, Irlam JJ, Taylor J, Denley H, Agrawal S, Choudhury A, Ryder D, Ord JJ, Harris AL, Rojas AM, Hoskin PJ, West CM. Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 108: 40-7. PMID 23773411 DOI: 10.1016/j.radonc.2013.05.017  0.791
2013 Giatromanolaki A, Koukourakis MI, Pouliliou S, Gatter KC, Pezzella F, Harris AL, Sivridis E. Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas. Hematology/Oncology and Stem Cell Therapy. 6: 20-5. PMID 23664601 DOI: 10.1016/j.hemonc.2013.02.001  0.654
2013 Singleton DC, Harris AL. Microenvironmental induced essentiality of autophagy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2791-3. PMID 23613319 DOI: 10.1158/1078-0432.CCR-13-0634  0.742
2013 Allevi G, Strina C, Andreis D, Zanoni V, Bazzola L, Bonardi S, Foroni C, Milani M, Cappelletti MR, Gussago F, Aguggini S, Giardini R, Martinotti M, Fox SB, Harris AL, et al. Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer. British Journal of Cancer. 108: 1587-92. PMID 23579222 DOI: 10.1038/bjc.2013.151  0.764
2013 Ong CC, Jubb AM, Jakubiak D, Zhou W, Rudolph J, Haverty PM, Kowanetz M, Yan Y, Tremayne J, Lisle R, Harris AL, Friedman LS, Belvin M, Middleton MR, Blackwood EM, et al. P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma. Journal of the National Cancer Institute. 105: 606-7. PMID 23535073 DOI: 10.1093/Jnci/Djt054  0.64
2013 McCormick RI, Blick C, Ragoussis J, Schoedel J, Mole DR, Young AC, Selby PJ, Banks RE, Harris AL. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. British Journal of Cancer. 108: 1133-42. PMID 23449350 DOI: 10.1038/bjc.2013.56  0.665
2013 Favaro E, Harris AL. Targeting glycogen metabolism: a novel strategy to inhibit cancer cell growth? Oncotarget. 4: 3-4. PMID 23448808  0.752
2013 Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M. Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts. Journal of Molecular Medicine (Berlin, Germany). 91: 749-58. PMID 23361368 DOI: 10.1007/s00109-013-0996-2  0.796
2013 Ramachandran A, Betts G, Bhana S, Helme G, Blick C, Moller-Levet C, Saunders E, Valentine H, Pepper S, Miller CJ, Buffa F, Harris AL, West CM. An in vivo hypoxia metagene identifies the novel hypoxia inducible factor target gene SLCO1B3. European Journal of Cancer (Oxford, England : 1990). 49: 1741-51. PMID 23352438 DOI: 10.1016/j.ejca.2012.12.003  0.677
2013 Giatromanolaki A, Koukourakis MI, Koutsopoulos AV, Harris AL, Gatter KC, Sivridis E. Autophagy and hypoxia in colonic adenomas related to aggressive features. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland. 15: e223-30. PMID 23351172 DOI: 10.1111/codi.12147  0.49
2013 Whiteman P, de Madrid BH, Taylor P, Li D, Heslop R, Viticheep N, Tan JZ, Shimizu H, Callaghan J, Masiero M, Li JL, Banham AH, Harris AL, Lea SM, Redfield C, et al. Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. The Journal of Biological Chemistry. 288: 7305-12. PMID 23339193 DOI: 10.1074/jbc.M112.428854  0.568
2013 Gieling RG, Parker CA, De Costa LA, Robertson N, Harris AL, Stratford IJ, Williams KJ. Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cells in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 360-9. PMID 23163664 DOI: 10.3109/14756366.2012.736979  0.748
2013 Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL. High DLL4 expression in tumour-associated vessels predicts for favorable radiotherapy outcome in locally advanced squamous cell head-neck cancer (HNSCC). Angiogenesis. 16: 343-51. PMID 23108591 DOI: 10.1007/s10456-012-9318-5  0.523
2013 Pike LR, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li JL, Simon AK, Murray JT, Harris AL. Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival. The Biochemical Journal. 449: 389-400. PMID 23078367 DOI: 10.1042/Bj20120972  0.829
2013 Betts GN, Eustace A, Patiar S, Valentine HR, Irlam J, Ramachandran A, Merve A, Homer JJ, Möller-Levet C, Buffa FM, Hall G, Miller CJ, Harris AL, West CM. Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma. European Journal of Cancer (Oxford, England : 1990). 49: 156-65. PMID 22951015 DOI: 10.1016/j.ejca.2012.07.028  0.766
2013 Hulikova A, Harris AL, Vaughan-Jones RD, Swietach P. Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia. Journal of Cellular Physiology. 228: 743-52. PMID 22949268 DOI: 10.1002/jcp.24221  0.612
2013 Charlesworth PJS, Sullivan ME, Protheroe A, Turner GDH, Roberts ISD, Kilbey N, Harris AL, Cranston D. Changing prognosis of renal cell carcinoma: A single-centre experience over 25 years Journal of Clinical Urology. 6: 119-124. DOI: 10.1177/2051415812473912  0.727
2013 Hoeflich K, Ong C, Lyle K, Jubb A, Zhou W, Harris A, Belvin M, Friedman L, Koeppen H, Rudolph J, Staben S. Abstract A067: Targeting p21-activated kinases in breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A067  0.674
2013 McIntyre A, Hulikova A, Ledaki I, Seden P, Turley H, Jones D, Russell A, Swietach P, Harris AL. Abstract 4053: Hypoxic trans-activation of sodium dependent bicarbonate co-transporters regulates pH in 3D spheroids and promotes growth. Cancer Research. 73: 4053-4053. DOI: 10.1158/1538-7445.Am2013-4053  0.817
2013 Harris AL, Generali D. Inhibitors of Tumor Angiogenesis Cancer Drug Design and Discovery: Second Edition. 275-317. DOI: 10.1016/B978-0-12-396521-9.00010-3  0.464
2013 Al-Ebraheem A, Geraki K, Leek R, Harris AL, Farquharson MJ. The use of bio-metal concentrations correlated with clinical prognostic factors to assess human breast tissues X-Ray Spectrometry. 42: 330-336. DOI: 10.1002/xrs.2463  0.581
2012 Favaro E, Bensaad K, Chong MG, Tennant DA, Ferguson DJ, Snell C, Steers G, Turley H, Li JL, Günther UL, Buffa FM, McIntyre A, Harris AL. Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells. Cell Metabolism. 16: 751-64. PMID 23177934 DOI: 10.1016/j.cmet.2012.10.017  0.814
2012 Pike LR, Phadwal K, Simon AK, Harris AL. ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. Molecular Biology Reports. 39: 10811-22. PMID 23090478 DOI: 10.1007/s11033-012-1975-3  0.734
2012 Jones DT, Lechertier T, Mitter R, Herbert JM, Bicknell R, Jones JL, Li JL, Buffa F, Harris AL, Hodivala-Dilke K. Gene expression analysis in human breast cancer associated blood vessels. Plos One. 7: e44294. PMID 23056178 DOI: 10.1371/journal.pone.0044294  0.772
2012 Singleton DC, Harris AL. Targeting the ATF4 pathway in cancer therapy. Expert Opinion On Therapeutic Targets. 16: 1189-202. PMID 23009153 DOI: 10.1517/14728222.2012.728207  0.769
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Harris AL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.405
2012 Giatromanolaki A, Koukourakis MI, Sivridis E, Gatter KC, Trarbach T, Folprecht G, Shi MM, Lebwohl D, Jalava T, Laurent D, Meinhardt G, Harris AL. Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials. British Journal of Cancer. 107: 1044-50. PMID 22910317 DOI: 10.1038/bjc.2012.369  0.524
2012 Biswas S, Charlesworth PJ, Turner GD, Leek R, Thamboo PT, Campo L, Turley H, Dildey P, Protheroe A, Cranston D, Gatter KC, Pezzella F, Harris AL. CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC. Carcinogenesis. 33: 1717-25. PMID 22777959 DOI: 10.1093/carcin/bgs222  0.823
2012 Swietach P, Hulikova A, Patiar S, Vaughan-Jones RD, Harris AL. Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin. Plos One. 7: e35949. PMID 22563426 DOI: 10.1371/journal.pone.0035949  0.763
2012 Jones DT, Harris AL. Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions. Expert Opinion On Therapeutic Targets. 16: 463-80. PMID 22512262 DOI: 10.1517/14728222.2012.674516  0.601
2012 McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, Vaughan-Jones RD, Swietach P, Harris AL. Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3100-11. PMID 22498007 DOI: 10.1158/1078-0432.CCR-11-1877  0.822
2012 Cavazzoni A, Bonelli MA, Fumarola C, La Monica S, Airoud K, Bertoni R, Alfieri RR, Galetti M, Tramonti S, Galvani E, Harris AL, Martin LA, Andreis D, Bottini A, Generali D, et al. Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones. Cancer Letters. 323: 77-87. PMID 22484466 DOI: 10.1016/j.canlet.2012.03.034  0.539
2012 Hulikova A, Harris AL, Vaughan-Jones RD, Swietach P. Acid-extrusion from tissue: the interplay between membrane transporters and pH buffers. Current Pharmaceutical Design. 18: 1331-7. PMID 22360560  0.586
2012 Jubb AM, Browning L, Campo L, Turley H, Steers G, Thurston G, Harris AL, Ansorge O. Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma. Histopathology. 60: 740-7. PMID 22296176 DOI: 10.1111/j.1365-2559.2011.04138.x  0.753
2012 Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, et al. Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. The Journal of Clinical Investigation. 122: 600-11. PMID 22214851 DOI: 10.1172/Jci58780  0.381
2012 Rzymski T, Petry A, Kračun D, Rieß F, Pike L, Harris AL, Görlach A. The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. Oncogene. 31: 3621-34. PMID 22105359 DOI: 10.1038/onc.2011.522  0.815
2012 Giatromanolaki A, Sivridis E, Bechrakis NE, Willerding G, St Charitoudis G, Foerster MH, Gatter KC, Harris AL, Koukourakis MI. Phosphorylated pVEGFR2/KDR receptor expression in uveal melanomas: relation with HIF2α and survival. Clinical & Experimental Metastasis. 29: 11-7. PMID 21984395 DOI: 10.1007/s10585-011-9424-6  0.551
2012 Mehta S, Hughes NP, Jubb AM, Turley H, Han C, Li SP, Taylor NJ, Padhani AR, Adams RF, Makris A, Harris AL. Early changes in angiogenesis and hypoxia following bevacizumab therapy in primary breast cancer. Journal of Clinical Oncology. 30: 1066-1066. DOI: 10.1200/JCO.2012.30.15_SUPPL.1066  0.765
2012 Ong C, Jubb A, Haverty P, Zhou W, Lyle K, Harris A, Belvin M, Friedman L, Koeppen H, Hoeflich KP. Abstract 4004: P21-activated kinases (PAKs) are novel therapeutic targets in human breast cancer Cancer Research. 72: 4004-4004. DOI: 10.1158/1538-7445.Am2012-4004  0.689
2012 Ong CC, Jubb AM, Haverty PM, Zhou W, Harris AL, Belvin M, Friedman LS, Koeppen H, Hoeflich KP. Abstract B8: Targeting p21-activated kinases in human lung cancer Clinical Cancer Research. 18: B8-B8. DOI: 10.1158/1078-0432.12Aacriaslc-B8  0.647
2011 Oon CE, Harris AL. New pathways and mechanisms regulating and responding to Delta-like ligand 4-Notch signalling in tumour angiogenesis. Biochemical Society Transactions. 39: 1612-8. PMID 22103496 DOI: 10.1042/BST20110721  0.695
2011 Berruti A, Generali D, Kaufmann M, Puztai L, Curigliano G, Aglietta M, Gianni L, Miller WR, Untch M, Sotiriou C, Daidone M, Conte P, Kennedy D, Damia G, Petronini P, ... ... Harris AL, et al. International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010). Journal of the National Cancer Institute. Monographs. 2011: 147-51. PMID 22043063 DOI: 10.1093/jncimonographs/lgr037  0.618
2011 Mehta S, Hughes NP, Buffa FM, Li SP, Adams RF, Adwani A, Taylor NJ, Levitt NC, Padhani AR, Makris A, Harris AL. Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles. Journal of the National Cancer Institute. Monographs. 2011: 71-4. PMID 22043045 DOI: 10.1093/jncimonographs/lgr027  0.812
2011 Generali D, Berruti A, Foroni C, Bazzola L, Andreis D, Allevi G, Bersiga A, Dogliotti L, Fox SB, Harris AL, Bottini A. Molecular oncology and the neoadjuvant setting: the perfect blend for treatment personalization and clinical trial design. Journal of the National Cancer Institute. Monographs. 2011: 67-70. PMID 22043044 DOI: 10.1093/jncimonographs/lgr029  0.622
2011 Liu SK, Bham SA, Fokas E, Beech J, Im J, Cho S, Harris AL, Muschel RJ. Delta-like ligand 4-notch blockade and tumor radiation response. Journal of the National Cancer Institute. 103: 1778-98. PMID 22010178 DOI: 10.1093/Jnci/Djr419  0.799
2011 Favaro E, Lord S, Harris AL, Buffa FM. Gene expression and hypoxia in breast cancer. Genome Medicine. 3: 55. PMID 21875443 DOI: 10.1186/gm271  0.833
2011 Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, ... Harris AL, et al. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Research. 71: 6073-83. PMID 21803743 DOI: 10.1158/0008-5472.Can-11-1704  0.805
2011 Buffa FM, Camps C, Winchester L, Snell CE, Gee HE, Sheldon H, Taylor M, Harris AL, Ragoussis J. microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer. Cancer Research. 71: 5635-45. PMID 21737487 DOI: 10.1158/0008-5472.CAN-11-0489  0.803
2011 Dubois L, Peeters S, Lieuwes NG, Geusens N, Thiry A, Wigfield S, Carta F, McIntyre A, Scozzafava A, Dogné JM, Supuran CT, Harris AL, Masereel B, Lambin P. Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 99: 424-31. PMID 21676479 DOI: 10.1016/J.Radonc.2011.05.045  0.738
2011 Ong CC, Jubb AM, Zhou W, Haverty PM, Harris AL, Belvin M, Friedman LS, Koeppen H, Hoeflich KP. p21-activated kinase 1: PAK'ed with potential. Oncotarget. 2: 491-6. PMID 21653999 DOI: 10.18632/Oncotarget.271  0.652
2011 Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Trarbach T, Folprecht G, Shi MM, Lebwohl D, Jalava T, Laurent D, Meinhardt G, Harris AL. Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 4892-900. PMID 21632858 DOI: 10.1158/1078-0432.CCR-10-2918  0.541
2011 Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li JL, Harris AL, Hammond EM, La Thangue NB. Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α. Oncogene. 30: 4835-42. PMID 21625218 DOI: 10.1038/onc.2011.188  0.687
2011 Serafin V, Persano L, Moserle L, Esposito G, Ghisi M, Curtarello M, Bonanno L, Masiero M, Ribatti D, Stürzl M, Naschberger E, Croner RS, Jubb AM, Harris AL, Koeppen H, et al. Notch3 signalling promotes tumour growth in colorectal cancer. The Journal of Pathology. 224: 448-60. PMID 21598247 DOI: 10.1002/path.2895  0.661
2011 Yan M, Jene N, Byrne D, Millar EK, O'Toole SA, McNeil CM, Bates GJ, Harris AL, Banham AH, Sutherland RL, Fox SB. Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers. Breast Cancer Research : Bcr. 13: R47. PMID 21521526 DOI: 10.1186/bcr2869  0.524
2011 Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP. Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 7177-82. PMID 21482786 DOI: 10.1073/Pnas.1103350108  0.767
2011 Bridges E, Oon CE, Harris A. Notch regulation of tumor angiogenesis. Future Oncology (London, England). 7: 569-88. PMID 21463145 DOI: 10.2217/fon.11.20  0.695
2011 Gee HE, Buffa FM, Camps C, Ramachandran A, Leek R, Taylor M, Patil M, Sheldon H, Betts G, Homer J, West C, Ragoussis J, Harris AL. The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. British Journal of Cancer. 104: 1168-77. PMID 21407217 DOI: 10.1038/sj.bjc.6606076  0.699
2011 Shaida N, Chan P, Turley H, Jones CM, Kanga S, Ritchie RW, Malone PR, Harris AL, Fox SB. Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. The Journal of Urology. 185: 1513-8. PMID 21334674 DOI: 10.1016/j.juro.2010.12.001  0.678
2011 Ghazoui Z, Buffa FM, Dunbier AK, Anderson H, Dexter T, Detre S, Salter J, Smith IE, Harris AL, Dowsett M. Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3005-12. PMID 21325071 DOI: 10.1158/1078-0432.CCR-10-1704  0.34
2011 Murri-Plesko MT, Hulikova A, Oosterwijk E, Scott AM, Zortea A, Harris AL, Ritter G, Old L, Bauer S, Swietach P, Renner C. Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX. European Journal of Pharmacology. 657: 173-83. PMID 21315712 DOI: 10.1016/j.ejphar.2011.01.063  0.619
2011 Fox SB, Generali D, Berruti A, Brizzi MP, Campo L, Bonardi S, Bersiga A, Allevi G, Milani M, Aguggini S, Mele T, Dogliotti L, Bottini A, Harris AL. The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen. Breast Cancer Research : Bcr. 13: R16. PMID 21291529 DOI: 10.1186/bcr2825  0.811
2011 Jubb AM, Miller KD, Rugo HS, Harris AL, Chen D, Reimann JD, Cobleigh MA, Schmidt M, Langmuir VK, Hillan KJ, Chen DS, Koeppen H. Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 372-81. PMID 21224365 DOI: 10.1158/1078-0432.Ccr-10-1791  0.675
2011 Blick C, McCormick R, Ramachandran A, Cranston D, Catto J, Harris A. 495 THE HYPOXIC REGULATION OF FGFR3 IN NON MUSCLE INVASIVE BLADDER CANCER European Urology Supplements. 10: 167. DOI: 10.1016/S1569-9056(11)60486-7  0.653
2010 Gijsen M, King P, Perera T, Parker PJ, Harris AL, Larijani B, Kong A. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. Plos Biology. 8: e1000563. PMID 21203579 DOI: 10.1371/journal.pbio.1000563  0.609
2010 Lord S, Harris AL. Angiogenesis - still a worthwhile target for breast cancer therapy? Breast Cancer Research : Bcr. 12: S19. PMID 21172081 DOI: 10.1186/bcr2748  0.668
2010 Jubb AM, Harris AL. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. The Lancet. Oncology. 11: 1172-83. PMID 21126687 DOI: 10.1016/S1470-2045(10)70232-1  0.651
2010 Giatromanolaki A, Koukourakis MI, Harris AL, Polychronidis A, Gatter KC, Sivridis E. Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas. Journal of Clinical Pathology. 63: 867-72. PMID 20876316 DOI: 10.1136/jcp.2010.079525  0.487
2010 Chen L, Zeng X, Wang J, Briggs SS, O'Neill E, Li J, Leek R, Kerr DJ, Harris AL, Cai S. Roles of tetrahydrobiopterin in promoting tumor angiogenesis. The American Journal of Pathology. 177: 2671-80. PMID 20847284 DOI: 10.2353/ajpath.2010.100025  0.767
2010 Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Research. 70: 6456-66. PMID 20682797 DOI: 10.1158/0008-5472.CAN-10-0413  0.822
2010 Mele T, Generali D, Fox S, Brizzi MP, Bersiga A, Milani M, Allevi G, Bonardi S, Aguggini S, Volante M, Dogliotti L, Bottini A, Harris A, Berruti A. Anti-angiogenic effect of tamoxifen combined with epirubicin in breast cancer patients. Breast Cancer Research and Treatment. 123: 795-804. PMID 20680681 DOI: 10.1007/s10549-010-1063-0  0.805
2010 Biswas S, Troy H, Leek R, Chung YL, Li JL, Raval RR, Turley H, Gatter K, Pezzella F, Griffiths JR, Stubbs M, Harris AL. Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts. Journal of Oncology. 2010: 757908. PMID 20652061 DOI: 10.1155/2010/757908  0.81
2010 da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, et al. Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. The American Journal of Pathology. 177: 1534-48. PMID 20639457 DOI: 10.2353/Ajpath.2010.100043  0.611
2010 Li JL, Jubb AM, Harris AL. Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. Future Oncology (London, England). 6: 1099-103. PMID 20624122 DOI: 10.2217/fon.10.62  0.77
2010 Sheldon H, Heikamp E, Turley H, Dragovic R, Thomas P, Oon CE, Leek R, Edelmann M, Kessler B, Sainson RC, Sargent I, Li JL, Harris AL. New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood. 116: 2385-94. PMID 20558614 DOI: 10.1182/blood-2009-08-239228  0.803
2010 McCormick R, Buffa FM, Ragoussis J, Harris AL. The role of hypoxia regulated microRNAs in cancer. Current Topics in Microbiology and Immunology. 345: 47-70. PMID 20549470 DOI: 10.1007/82_2010_76  0.735
2010 Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene. 29: 4424-35. PMID 20514020 DOI: 10.1038/onc.2010.191  0.801
2010 Gossage L, Zaitoun A, Fareed KR, Turley H, Aloysius M, Lobo DN, Harris AL, Madhusudan S. Expression of key hypoxia sensing prolyl-hydroxylases PHD1, -2 and -3 in pancreaticobiliary cancer. Histopathology. 56: 908-20. PMID 20497244 DOI: 10.1111/j.1365-2559.2010.03566.x  0.589
2010 Liu D, Hu J, Agorreta J, Cesario A, Zhang Y, Harris AL, Gatter K, Pezzella F. Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases. Cancer Letters. 296: 194-205. PMID 20471161 DOI: 10.1016/j.canlet.2010.04.017  0.574
2010 Thurlow JK, Peña Murillo CL, Hunter KD, Buffa FM, Patiar S, Betts G, West CM, Harris AL, Parkinson EK, Harrison PR, Ozanne BW, Partridge M, Kalna G. Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 2881-8. PMID 20458058 DOI: 10.1200/Jco.2009.24.8724  0.754
2010 Grzmil M, Rzymski T, Milani M, Harris AL, Capper RG, Saunders NJ, Salhan A, Ragoussis J, Norbury CJ. An oncogenic role of eIF3e/INT6 in human breast cancer. Oncogene. 29: 4080-9. PMID 20453879 DOI: 10.1038/Onc.2010.152  0.832
2010 Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li JL, Vojnovic B, Pires das Neves R, Glazer P, Iborra F, Ivan M, ... ... Harris AL, et al. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. Plos One. 5: e10345. PMID 20436681 DOI: 10.1371/Journal.Pone.0010345  0.794
2010 Sivridis E, Koukourakis MI, Zois CE, Ledaki I, Ferguson DJ, Harris AL, Gatter KC, Giatromanolaki A. LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. The American Journal of Pathology. 176: 2477-89. PMID 20382705 DOI: 10.2353/ajpath.2010.090049  0.815
2010 Azam F, Mehta S, Harris AL. Mechanisms of resistance to antiangiogenesis therapy. European Journal of Cancer (Oxford, England : 1990). 46: 1323-32. PMID 20236818 DOI: 10.1016/j.ejca.2010.02.020  0.822
2010 Gee HE, Camps C, Buffa FM, Patiar S, Winter SC, Betts G, Homer J, Corbridge R, Cox G, West CM, Ragoussis J, Harris AL. hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer. Cancer. 116: 2148-58. PMID 20187102 DOI: 10.1002/cncr.25009  0.786
2010 Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, Blades J, Li JL, Allen P, Leek R, Noguera-Troise I, Gatter KC, Thurston G, Harris AL. Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. The American Journal of Pathology. 176: 2019-28. PMID 20167860 DOI: 10.2353/ajpath.2010.090908  0.824
2010 Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Research. 70: 925-35. PMID 20103649 DOI: 10.1158/0008-5472.CAN-09-2715  0.751
2010 Mellor HR, Rouschop KM, Wigfield SM, Wouters BG, Harris AL. Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase. Biochemical Pharmacology. 79: 1562-72. PMID 20100468 DOI: 10.1016/j.bcp.2010.01.019  0.787
2010 Buffa FM, Harris AL, West CM, Miller CJ. Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene. British Journal of Cancer. 102: 428-35. PMID 20087356 DOI: 10.1038/sj.bjc.6605450  0.318
2010 Bonelli MA, Fumarola C, Alfieri RR, La Monica S, Cavazzoni A, Galetti M, Gatti R, Belletti S, Harris AL, Fox SB, Evans DB, Dowsett M, Martin LA, Bottini A, Generali D, et al. Synergistic activity of letrozole and sorafenib on breast cancer cells. Breast Cancer Research and Treatment. 124: 79-88. PMID 20054642 DOI: 10.1007/s10549-009-0714-5  0.657
2010 Charlesworth PJ, Kilbey N, Taylor M, Leek R, Cranston D, Turner G, Crew J, Harris A, Protheroe A. Automated uro-oncology data collection: the Cancer Research Uro-Oncology Database. Bju International. 105: 1663-6. PMID 19930178 DOI: 10.1111/j.1464-410X.2009.09058.x  0.786
2010 Jubb AM, Buffa FM, Harris AL. Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. Journal of Cellular and Molecular Medicine. 14: 18-29. PMID 19840191 DOI: 10.1111/j.1582-4934.2009.00944.x  0.686
2010 Gijsen M, King P, Perera T, Parker P, Larijani B, Harris A, Kong A. Upregulation of ADAM proteases and HER ligands through a feedback loop mediates acquired resistance to trastuzumab in HER2-amplified breast cancer Breast Cancer Research. 12. DOI: 10.1186/bcr2493  0.6
2010 Hoeflich K, Ong C, Jubb A, Haverty P, Truong T, Harris A, Belvin M, Friedman L, Blackwood E, Koeppen H. 343 Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells European Journal of Cancer Supplements. 8: 109. DOI: 10.1016/S1359-6349(10)72050-4  0.609
2010 Oon C, Li J, Sainson R, Sheldon H, Turley H, Leek R, Harris A. 360 Role of DLL4 and JAG1 in tumour angiogenesis European Journal of Cancer Supplements. 8: 92. DOI: 10.1016/S1359-6349(10)71161-7  0.793
2009 Patel NS, Muneer A, Blick C, Arya M, Harris AL. Targeting vascular endothelial growth factor in renal cell carcinoma. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 30: 292-9. PMID 19940550 DOI: 10.1159/000260241  0.777
2009 Koukourakis MI, Giatromanolaki A, Winter S, Leek R, Sivridis E, Harris AL. Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy. Oncology. 77: 285-92. PMID 19923867 DOI: 10.1159/000259260  0.773
2009 Rzymski T, Milani M, Singleton DC, Harris AL. Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell Cycle (Georgetown, Tex.). 8: 3838-47. PMID 19887912 DOI: 10.4161/cc.8.23.10086  0.805
2009 Koukourakis MI, Giatromanolaki A, Sheldon H, Buffa FM, Kouklakis G, Ragoussis I, Sivridis E, Harris AL. Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7069-76. PMID 19887481 DOI: 10.1158/1078-0432.CCR-09-0688  0.515
2009 Yang J, Ledaki I, Turley H, Gatter KC, Montero JC, Li JL, Harris AL. Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases. Annals of the New York Academy of Sciences. 1177: 185-97. PMID 19845621 DOI: 10.1111/j.1749-6632.2009.05027.x  0.771
2009 Jubb AM, Turley H, Moeller HC, Steers G, Han C, Li JL, Leek R, Tan EY, Singh B, Mortensen NJ, Noguera-Troise I, Pezzella F, Gatter KC, Thurston G, Fox SB, ... Harris AL, et al. Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. British Journal of Cancer. 101: 1749-57. PMID 19844231 DOI: 10.1038/sj.bjc.6605368  0.835
2009 Turley H, Steers G, Li JL, Sainson R, Harris AL, Pezzella F, Gatter KC. Corrigendum. Histopathology. 55: 463-4. PMID 19817897 DOI: 10.1111/j.1365-2559.2009.03412.x  0.777
2009 Mujcic H, Rzymski T, Rouschop KM, Koritzinsky M, Milani M, Harris AL, Wouters BG. Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 92: 450-9. PMID 19726095 DOI: 10.1016/j.radonc.2009.08.017  0.835
2009 Poon E, Harris AL, Ashcroft M. Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Reviews in Molecular Medicine. 11: e26. PMID 19709449 DOI: 10.1017/S1462399409001173  0.34
2009 Farquharson MJ, Al-Ebraheem A, Geraki K, Leek R, Jubb A, Harris AL. Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor status. Physics in Medicine and Biology. 54: 4213-23. PMID 19521003 DOI: 10.1088/0031-9155/54/13/016  0.738
2009 Swietach P, Patiar S, Supuran CT, Harris AL, Vaughan-Jones RD. The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. The Journal of Biological Chemistry. 284: 20299-310. PMID 19458084 DOI: 10.1074/jbc.M109.006478  0.778
2009 Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Guenther T. Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. British Journal of Cancer. 100: 1666-73. PMID 19436307 DOI: 10.1038/sj.bjc.6605026  0.577
2009 Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D, Harris AL. The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Research. 69: 4415-23. PMID 19417138 DOI: 10.1158/0008-5472.CAN-08-2839  0.819
2009 Martinez JC, Müller MM, Turley H, Steers G, Choteau L, Li JL, Sainson R, Harris AL, Pezzella F, Gatter KC. Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues. Histopathology. 54: 598-606. PMID 19413639 DOI: 10.1111/j.1365-2559.2009.03279.x  0.809
2009 Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, ... ... Harris AL, et al. Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 1-39. PMID 19330638 DOI: 10.1080/14756360902784425  0.302
2009 Lowndes SA, Sheldon HV, Cai S, Taylor JM, Harris AL. Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms. Microvascular Research. 77: 314-26. PMID 19323979 DOI: 10.1016/j.mvr.2009.01.003  0.781
2009 Li JL, Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Frontiers in Bioscience (Landmark Edition). 14: 3094-110. PMID 19273260 DOI: 10.2741/3438  0.653
2009 Generali D, Bates G, Berruti A, Brizzi MP, Campo L, Bonardi S, Bersiga A, Allevi G, Milani M, Aguggini S, Dogliotti L, Banham AH, Harris AL, Bottini A, Fox SB. Immunomodulation of FOXP3+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1046-51. PMID 19188178 DOI: 10.1158/1078-0432.CCR-08-1507  0.786
2009 Tan EY, Yan M, Campo L, Han C, Takano E, Turley H, Candiloro I, Pezzella F, Gatter KC, Millar EK, O'Toole SA, McNeil CM, Crea P, Segara D, Sutherland RL, ... Harris AL, et al. The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. British Journal of Cancer. 100: 405-11. PMID 19165203 DOI: 10.1038/sj.bjc.6604844  0.765
2009 Generali D, Buffa FM, Berruti A, Brizzi MP, Campo L, Bonardi S, Bersiga A, Allevi G, Milani M, Aguggini S, Papotti M, Dogliotti L, Bottini A, Harris AL, Fox SB. Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 227-34. PMID 19064988 DOI: 10.1200/JCO.2007.13.7083  0.798
2009 Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Guenther T. Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. Pathology, Research and Practice. 205: 1-9. PMID 19008051 DOI: 10.1016/j.prp.2008.08.008  0.56
2009 Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JMA, Guenther T. Erratum: Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis British Journal of Cancer. 101: 742-742. DOI: 10.1038/sj.bjc.6605242  0.566
2009 Charlesworth P, Protheroe A, Turner G, Roberts I, Harris A, Cranston D. 240 24 YEARS OF RENAL CELL CARCINOMA NEPHRECTOMIES IN OXFORD, UK (1983-2007) European Urology Supplements. 8: 180. DOI: 10.1016/S1569-9056(09)60245-1  0.724
2009 Jensen H, Nordsmark M, Donskov F, Marcussen N, Turley H, Gatter K, Harris A, von der Maase H. 7103 Baseline and on-treatment expression of HIF-1a, HIF-2a and CAIX in patients with metastatic renal cell carcinoma European Journal of Cancer Supplements. 7: 423. DOI: 10.1016/S1359-6349(09)71436-3  0.529
2009 Swietach P, Patiar S, Villafuerte FC, Harris AL, Vaughan-Jones RD. Confocal Imaging Of Extracellular pH With Fluorescein Derivatives Biophysical Journal. 96: 298a. DOI: 10.1016/j.bpj.2008.12.1481  0.715
2008 Giatromanolaki A, Koukourakis MI, Pezzella F, Sivridis E, Turley H, Harris AL, Gatter KC. Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins. Leukemia & Lymphoma. 49: 2181-6. PMID 19021062 DOI: 10.1080/10428190802450629  0.761
2008 Lowndes SA, Adams A, Timms A, Fisher N, Smythe J, Watt SM, Joel S, Donate F, Hayward C, Reich S, Middleton M, Mazar A, Harris AL. Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7526-34. PMID 19010871 DOI: 10.1158/1078-0432.CCR-08-0315  0.73
2008 Milani M, Harris AL. Targeting tumour hypoxia in breast cancer. European Journal of Cancer (Oxford, England : 1990). 44: 2766-73. PMID 18990559 DOI: 10.1016/j.ejca.2008.09.025  0.715
2008 Gee HE, Camps C, Buffa FM, Colella S, Sheldon H, Gleadle JM, Ragoussis J, Harris AL. MicroRNA-10b and breast cancer metastasis. Nature. 455: E8-9; author reply E. PMID 18948893 DOI: 10.1038/nature07362  0.713
2008 Kong A, Calleja V, Leboucher P, Harris A, Parker PJ, Larijani B. HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells. Plos One. 3: e2881. PMID 18682844 DOI: 10.1371/journal.pone.0002881  0.615
2008 Giatromanolaki A, Bates GJ, Koukourakis MI, Sivridis E, Gatter KC, Harris AL, Banham AH. The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer. Gynecologic Oncology. 110: 216-21. PMID 18533240 DOI: 10.1016/j.ygyno.2008.04.021  0.525
2008 Generali D, Dovio A, Tampellini M, Tucci M, Tedoldi S, Torta M, Bonardi S, Allevi G, Aguggini S, Milani M, Harris AL, Bottini A, Dogliotti L, Angeli A, Berruti A. Changes of bone turnover markers and serum PTH after night or morning administration of zoledronic acid in breast cancer patients with bone metastases. British Journal of Cancer. 98: 1753-8. PMID 18506177 DOI: 10.1038/sj.bjc.6604390  0.699
2008 Farquharson MJ, Al-Ebraheem A, Falkenberg G, Leek R, Harris AL, Bradley DA. The distribution of trace elements Ca, Fe, Cu and Zn and the determination of copper oxidation state in breast tumour tissue using muSRXRF and muXANES. Physics in Medicine and Biology. 53: 3023-37. PMID 18490810 DOI: 10.1088/0031-9155/53/11/018  0.555
2008 Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, Vaughan-Jones RD. Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. The Journal of Biological Chemistry. 283: 20473-83. PMID 18482982 DOI: 10.1074/jbc.M801330200  0.776
2008 Giatromanolaki A, Koukourakis MI, Pezzella F, Sivridis E, Turley H, Harris AL, Gatter KC. Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation. Hematological Oncology. 26: 219-24. PMID 18461646 DOI: 10.1002/hon.861  0.772
2008 Smythe J, Fox A, Fisher N, Frith E, Harris AL, Watt SM. Measuring angiogenic cytokines, circulating endothelial cells, and endothelial progenitor cells in peripheral blood and cord blood: VEGF and CXCL12 correlate with the number of circulating endothelial progenitor cells in peripheral blood. Tissue Engineering. Part C, Methods. 14: 59-67. PMID 18454646 DOI: 10.1089/tec.2007.0251  0.801
2008 Generali D, Fox SB, Brizzi MP, Allevi G, Bonardi S, Aguggini S, Milani M, Bersiga A, Campo L, Dionisio R, Vergoni F, Giardini R, Dogliotti L, Bottini A, Harris AL, et al. Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 2673-80. PMID 18451231 DOI: 10.1158/1078-0432.CCR-07-1046  0.793
2008 Swietach P, Wigfield S, Supuran CT, Harris AL, Vaughan-Jones RD. Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion. Bju International. 101: 22-4. PMID 18430118 DOI: 10.1111/j.1464-410X.2008.07644.x  0.781
2008 Rzymski T, Paantjens A, Bod J, Harris AL. Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4. Oncogene. 27: 4532-43. PMID 18408768 DOI: 10.1038/onc.2008.100  0.701
2008 Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Research. 68: 1889-95. PMID 18339870 DOI: 10.1158/0008-5472.CAN-07-2181  0.713
2008 Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. British Journal of Haematology. 141: 672-5. PMID 18318758 DOI: 10.1111/j.1365-2141.2008.07077.x  0.526
2008 Sainson RC, Harris AL. Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies. Angiogenesis. 11: 41-51. PMID 18256896 DOI: 10.1007/s10456-008-9098-0  0.7
2008 Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, et al. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1118-30. PMID 18234890 DOI: 10.1523/Jneurosci.2262-07.2008  0.514
2008 Giatromanolaki A, Koukourakis MI, Pezzella F, Turley H, Sivridis E, Bouros D, Bougioukas G, Harris AL, Gatter KC. Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway. Cancer Letters. 262: 87-93. PMID 18187257 DOI: 10.1016/j.canlet.2007.11.041  0.761
2008 Shaida N, Launchbury R, Boddy JL, Jones C, Campo L, Turley H, Kanga S, Banham AH, Malone PR, Harris AL, Fox SB. Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines. The Prostate. 68: 336-43. PMID 18163427 DOI: 10.1002/pros.20707  0.819
2008 Bates GJ, Fox SB, Han C, Launchbury R, Leek RD, Harris AL, Banham AH. Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas. Breast Cancer Research and Treatment. 111: 453-9. PMID 18026833 DOI: 10.1007/s10549-007-9812-4  0.712
2008 Harrington LS, Sainson RC, Williams CK, Taylor JM, Shi W, Li JL, Harris AL. Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvascular Research. 75: 144-54. PMID 17692341 DOI: 10.1016/j.mvr.2007.06.006  0.822
2008 Giatromanolaki A, Koukourakis MI, Gatter KC, Harris AL, Sivridis E. BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis. Journal of Clinical Pathology. 61: 217-20. PMID 17513511 DOI: 10.1136/jcp.2007.046680  0.58
2008 Ameri K, Harris AL. Activating transcription factor 4. The International Journal of Biochemistry & Cell Biology. 40: 14-21. PMID 17466566 DOI: 10.1016/j.biocel.2007.01.020  0.789
2008 Kong A, Calleja V, Leboucher P, Harris A, Parker P, Larijani B. Activation of alternative HER receptors mediates resistance to EGFR tyrosine kinase inhibitors in breast cancer cells European Journal of Cancer Supplements. 6: 9. DOI: 10.1016/S1359-6349(08)71210-2  0.593
2008 Harris AL, Generali DG. Inhibitors of tumor angiogenesis Cancer Drug Design and Discovery. 351-381. DOI: 10.1016/B978-012369448-5.50018-5  0.532
2008 Charlesworth PJS, Harris AL. Hypoxic regulation of angiogenesis by HIF-1 Angiogenesis: An Integrative Approach From Science to Medicine. 169-179. DOI: 10.1007/978-0-387-71518-6_15  0.768
2007 Fox SB, Generali DG, Harris AL. Breast tumour angiogenesis. Breast Cancer Research : Bcr. 9: 216. PMID 18190723 DOI: 10.1186/bcr1796  0.632
2007 Tan EY, Campo L, Han C, Turley H, Pezzella F, Gatter KC, Harris AL, Fox SB. Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer. Breast Cancer Research : Bcr. 9: R89. PMID 18096060 DOI: 10.1186/bcr1838  0.777
2007 Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E, Hainfellner JA, Harris AL. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Research. 67: 11244-53. PMID 18056450 DOI: 10.1158/0008-5472.CAN-07-0969  0.812
2007 Kato T, Steers G, Campo L, Roberts H, Leek RD, Turley H, Kimura T, Kameoka S, Nishikawa T, Kobayashi M, Harris AL, Gatter KC, Pezzella F. Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer. British Journal of Cancer. 97: 1277-86. PMID 17923874 DOI: 10.1038/sj.bjc.6604015  0.77
2007 Sainson RC, Harris AL. Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends in Molecular Medicine. 13: 389-95. PMID 17822956 DOI: 10.1016/j.molmed.2007.07.002  0.705
2007 Mellor HR, Harris AL. The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer. Cancer Metastasis Reviews. 26: 553-66. PMID 17805942 DOI: 10.1007/s10555-007-9080-0  0.727
2007 Ord JJ, Agrawal S, Thamboo TP, Roberts I, Campo L, Turley H, Han C, Fawcett DW, Kulkarni RP, Cranston D, Harris AL. An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer. The Journal of Urology. 178: 677-82. PMID 17574616 DOI: 10.1016/j.juro.2007.03.112  0.81
2007 Li JL, Harris AL. The potential of new tumor endothelium-specific markers for the development of antivascular therapy. Cancer Cell. 11: 478-81. PMID 17560330 DOI: 10.1016/j.ccr.2007.05.004  0.657
2007 Trivella M, Pezzella F, Pastorino U, Harris AL, Altman DG. Microvessel density as a prognostic factor in non-small-cell lung carcinoma: a meta-analysis of individual patient data. The Lancet. Oncology. 8: 488-99. PMID 17513172 DOI: 10.1016/S1470-2045(07)70145-6  0.523
2007 Knowles HJ, Harris AL. Macrophages and the hypoxic tumour microenvironment. Frontiers in Bioscience : a Journal and Virtual Library. 12: 4298-314. PMID 17485376 DOI: 10.2741/2389  0.635
2007 Banham AH, Boddy J, Launchbury R, Han C, Turley H, Malone PR, Harris AL, Fox SB. Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia. The Prostate. 67: 1091-8. PMID 17477366 DOI: 10.1002/pros.20583  0.821
2007 Rzymski T, Harris AL. The unfolded protein response and integrated stress response to anoxia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2537-40. PMID 17473181 DOI: 10.1158/1078-0432.CCR-06-2126  0.703
2007 Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Reviews. 26: 299-310. PMID 17415526 DOI: 10.1007/s10555-007-9064-0  0.622
2007 Winter SC, Buffa FM, Silva P, Miller C, Valentine HR, Turley H, Shah KA, Cox GJ, Corbridge RJ, Homer JJ, Musgrove B, Slevin N, Sloan P, Price P, West CM, ... Harris AL, et al. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. Cancer Research. 67: 3441-9. PMID 17409455 DOI: 10.1158/0008-5472.CAN-06-3322  0.743
2007 Fox SB, Launchbury R, Bates GJ, Han C, Shaida N, Malone PR, Harris AL, Banham AH. The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2alpha but not HIF-1alpha. The Prostate. 67: 623-9. PMID 17328069 DOI: 10.1002/pros.20538  0.435
2007 Sung FL, Hui EP, Tao Q, Li H, Tsui NB, Lo YM, Ma BB, To KF, Harris AL, Chan AT. Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in nasopharyngeal carcinoma. Cancer Letters. 253: 74-88. PMID 17320280 DOI: 10.1016/J.Canlet.2007.01.012  0.301
2007 Generali D, Fox SB, Berruti A, Moore JW, Brizzi MP, Patel N, Allevi G, Bonardi S, Aguggini S, Bersiga A, Campo L, Dogliotti L, Bottini A, Harris AL. Regulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 550-8. PMID 17255277 DOI: 10.1158/1078-0432.CCR-06-1266  0.769
2007 Tan EY, Campo L, Han C, Turley H, Pezzella F, Gatter KC, Harris AL, Fox SB. BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 467-74. PMID 17255267 DOI: 10.1158/1078-0432.CCR-06-1466  0.779
2007 Generali D, Leek R, Fox SB, Moore JW, Taylor C, Chambers P, Harris AL. EGFR mutations in exons 18-21 in sporadic breast cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 18: 203-5. PMID 17220285 DOI: 10.1093/annonc/mdl322  0.723
2007 Generali D, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield S, Bersiga A, Allevi G, Milani M, Aguggini S, Gandolfi V, Dogliotti L, Bottini A, Harris AL, Fox SB. Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 4562-8. PMID 16899602 DOI: 10.1158/1078-0432.CCR-05-2690  0.823
2007 Generali DG, Berruti A, Fox SB, Brizzi M, Bonardi S, Milani M, Bersiga A, Dionisio R, Dogliotti L, Bottini A, Harris AL. Down-regulation of HIF-1α expression by letrozole in ER+ve breast cancer patients Journal of Clinical Oncology. 25: 510-510. DOI: 10.1200/JCO.2007.25.18_SUPPL.510  0.775
2007 Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL, Trarbach T, Folprecht G, Shi MM, Meinhardt G. Intratumoral lactate dehydrogenase 5 (LDH5) protein expression is associated with expression of angiogenesis markers and hypoxia in patients with colorectal cancer (CRC) Journal of Clinical Oncology. 25: 4107-4107. DOI: 10.1200/jco.2007.25.18_suppl.4107  0.523
2007 Sainson RCA, Li J, Harrington L, Shi W, Heikamp E, Leek R, Harris AL. In vivo assessment of Delta like‐4 function in tumour development The Faseb Journal. 21. DOI: 10.1096/fasebj.21.5.a16  0.771
2007 Koukourakis M, Giatromanolaki A, Sivridis E, Gatter K, Harris A, Shi M, Trarbach T, Folprecht G, Meinhardt G. 327 POSTER Expression of intratumoral lactate dehydrogenase 5 (LDH5) and expression of biomarkers for angiogenesis and hypoxia are linked in patients with colorectal cancer (CRC) European Journal of Cancer Supplements. 5: 64-65. DOI: 10.1016/S1359-6349(07)70345-2  0.511
2007 Van der Auwera I, Cao Y, Tille JC, Pepper MS, Jackson DG, Fox SB, Harris AL, Dirix LY, Vermeulen PB. First International Consensus on the Methodology of Lymphangiogenesis Quantification in Solid Human Tumors Cheminform. 38. DOI: 10.1002/CHIN.200725276  0.386
2006 Patiar S, Harris AL. Role of hypoxia-inducible factor-1alpha as a cancer therapy target. Endocrine-Related Cancer. 13: S61-75. PMID 17259560 DOI: 10.1677/erc.1.01290  0.803
2006 Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL, Banham AH. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 5373-80. PMID 17135638 DOI: 10.1200/JCO.2006.05.9584  0.703
2006 Van der Auwera I, Cao Y, Tille JC, Pepper MS, Jackson DG, Fox SB, Harris AL, Dirix LY, Vermeulen PB. First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. British Journal of Cancer. 95: 1611-25. PMID 17117184 DOI: 10.1038/Sj.Bjc.6603445  0.446
2006 Farquharson MJ, Geraki K, Falkenberg G, Leek R, Harris A. The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 65: 183-8. PMID 17052909 DOI: 10.1016/J.APRADISO.2006.08.013  0.59
2006 Jones DT, Pugh CW, Wigfield S, Stevens MF, Harris AL. Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5384-94. PMID 17000671 DOI: 10.1158/1078-0432.CCR-05-2380  0.802
2006 Jones DT, Harris AL. Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding. Molecular Cancer Therapeutics. 5: 2193-202. PMID 16985052 DOI: 10.1158/1535-7163.MCT-05-0443  0.626
2006 Generali D, Fox SB, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield SM, Bruzzi P, Bersiga A, Allevi G, Milani M, Aguggini S, Dogliotti L, Bottini A, Harris AL. Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer. Endocrine-Related Cancer. 13: 921-30. PMID 16954440 DOI: 10.1677/erc.1.01216  0.814
2006 Shi W, Harris AL. Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials Journal of Mammary Gland Biology and Neoplasia. 11: 41-52. PMID 16947085 DOI: 10.1007/s10911-006-9011-7  0.5
2006 Desmedt C, Ouriaghli FE, Durbecq V, Soree A, Colozza MA, Azambuja E, Paesmans M, Larsimont D, Buyse M, Harris A, Piccart M, Martiat P, Sotiriou C. Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients. International Journal of Cancer. 119: 2539-45. PMID 16929516 DOI: 10.1002/ijc.22149  0.31
2006 Lowndes SA, Harris AL. The role of copper in tumour angiogenesis. Journal of Mammary Gland Biology and Neoplasia. 10: 299-310. PMID 16924372 DOI: 10.1007/s10911-006-9003-7  0.761
2006 Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K, Cranston DW, Li JL, Harris AL. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer Clinical Cancer Research. 12: 4836-4844. PMID 16914569 DOI: 10.1158/1078-0432.CCR-06-0285  0.769
2006 Giatromanolaki A, Sivridis E, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, Koukourakis MI. Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas. Journal of Surgical Oncology. 94: 242-7. PMID 16900513 DOI: 10.1002/JSO.20443  0.495
2006 Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 4301-8. PMID 16896001 DOI: 10.1200/JCO.2006.05.9501  0.554
2006 Adam PJ, Terrett JA, Steers G, Stockwin L, Loader JA, Fletcher GC, Lu LS, Leach BI, Mason S, Stamps AC, Boyd RS, Pezzella F, Gatter KC, Harris AL. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. British Journal of Cancer. 95: 298-306. PMID 16892042 DOI: 10.1038/sj.bjc.6603222  0.517
2006 Bottini A, Generali D, Brizzi MP, Fox SB, Bersiga A, Bonardi S, Allevi G, Aguggini S, Bodini G, Milani M, Dionisio R, Bernardi C, Montruccoli A, Bruzzi P, Harris AL, et al. Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 3623-8. PMID 16877730 DOI: 10.1200/JCO.2005.04.5773  0.761
2006 Raida M, Weiss T, Leo C, Lenz D, Tarnok A, Ameri K, Harris AL, Höckel M, Niederwieser D. Circulating endothelial progenitor cells are inversely correlated with the median oxygen tension in the tumor tissue of patients with cervical cancer. Oncology Reports. 16: 597-601. PMID 16865261 DOI: 10.3892/OR.16.3.597  0.697
2006 Ameri K, Hammond EM, Culmsee C, Raida M, Katschinski DM, Wenger RH, Wagner E, Davis RJ, Hai T, Denko N, Harris AL. Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene. 26: 284-9. PMID 16847457 DOI: 10.1038/Sj.Onc.1209781  0.687
2006 Koukourakis MI, Papazoglou D, Giatromanolaki A, Panagopoulos I, Maltezos E, Harris AL, Gatter KC, Sivridis E. C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 53: 257-62. PMID 16837101 DOI: 10.1016/j.lungcan.2006.05.025  0.464
2006 Giatromanolaki A, Sivridis E, Gatter KC, Turley H, Harris AL, Koukourakis MI. Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis. Gynecologic Oncology. 103: 912-8. PMID 16837029 DOI: 10.1016/j.ygyno.2006.05.043  0.711
2006 Koukourakis MI, Giatromanolaki A, Polychronidis A, Simopoulos C, Gatter KC, Harris AL, Sivridis E. Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer. Cancer Science. 97: 582-8. PMID 16827797 DOI: 10.1111/j.1349-7006.2006.00220.x  0.575
2006 Winter SC, Shah KA, Han C, Campo L, Turley H, Leek R, Corbridge RJ, Cox GJ, Harris AL. The relation between hypoxia-inducible factor (HIF)=1α and HIF-2α expression with anemia and outcome in surgically treated head and neck cancer Cancer. 107: 757-766. PMID 16826581 DOI: 10.1002/cncr.21983  0.788
2006 Bacon AL, Fox S, Turley H, Harris AL. Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Oncogene. 26: 132-41. PMID 16799636 DOI: 10.1038/sj.onc.1209761  0.822
2006 Boddy JL, Gal S, Malone PR, Shaida N, Wainscoat JS, Harris AL. The role of cell-free DNA size distribution in the management of prostate cancer. Oncology Research. 16: 35-41. PMID 16783966 DOI: 10.3727/000000006783981297  0.721
2006 Giatromanolaki A, Koukourakis MI, Turley H, Sivridis E, Harris AL, Gatter KC. Phosphorylated KDR expression in endometrial cancer cells relates to HIF1alpha/VEGF pathway and unfavourable prognosis. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 19: 701-7. PMID 16557278 DOI: 10.1038/modpathol.3800579  0.729
2006 Charlesworth PJ, Harris AL. Mechanisms of disease: angiogenesis in urologic malignancies. Nature Clinical Practice. Urology. 3: 157-69. PMID 16528288 DOI: 10.1038/ncpuro0434  0.8
2006 Sainson RC, Harris AL. Hypoxia-regulated differentiation: let's step it up a Notch. Trends in Molecular Medicine. 12: 141-3. PMID 16513423 DOI: 10.1016/j.molmed.2006.02.001  0.726
2006 Kong A, Leboucher P, Leek R, Calleja V, Winter S, Harris A, Parker PJ, Larijani B. Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer. Cancer Research. 66: 2834-43. PMID 16510606 DOI: 10.1158/0008-5472.CAN-05-2994  0.799
2006 Jones DT, Trowbridge IS, Harris AL. Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cancer Research. 66: 2749-56. PMID 16510596 DOI: 10.1158/0008-5472.Can-05-3857  0.621
2006 Knowles HJ, Mole DR, Ratcliffe PJ, Harris AL. Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Research. 66: 2600-7. PMID 16510578 DOI: 10.1158/0008-5472.Can-05-2351  0.652
2006 Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, Nordgren H, Farmer P, Praz V, Haibe-Kains B, Desmedt C, Larsimont D, Cardoso F, Peterse H, Nuyten D, et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. Journal of the National Cancer Institute. 98: 262-72. PMID 16478745 DOI: 10.1093/jnci/djj052  0.49
2006 Blazquez C, Cook N, Micklem K, Harris AL, Gatter KC, Pezzella F. Phosphorylated KDR can be located in the nucleus of neoplastic cells. Cell Research. 16: 93-8. PMID 16467880 DOI: 10.1038/sj.cr.7310012  0.535
2006 Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Research. 66: 632-7. PMID 16423989 DOI: 10.1158/0008-5472.CAN-05-3260  0.515
2006 Koukourakis MI, Bentzen SM, Giatromanolaki A, Wilson GD, Daley FM, Saunders MI, Dische S, Sivridis E, Harris AL. Endogenous Markers of Two Separate Hypoxia Response Pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) Are Associated With Radiotherapy Failure in Head and Neck Cancer Patients Recruited in the CHART Randomized Trial Journal of Clinical Oncology. 24: 727-735. PMID 16418497 DOI: 10.1200/Jco.2005.02.7474  0.532
2006 Knowles HJ, te Poele RH, Te Poole R, Workman P, Harris AL. Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochemical Pharmacology. 71: 646-56. PMID 16386710 DOI: 10.1016/j.bcp.2005.11.019  0.659
2006 Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL. Inclusion of vasculature-related variables in the Dukes staging system of colon cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 8653-60. PMID 16361550 DOI: 10.1158/1078-0432.CCR-05-1464  0.461
2006 Smith CL, Mirza F, Pasquetto V, Tscharke DC, Palmowski MJ, Dunbar PR, Sette A, Harris AL, Cerundolo V. Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara. Journal of Immunology (Baltimore, Md. : 1950). 175: 8431-7. PMID 16339586 DOI: 10.4049/Jimmunol.175.12.8431  0.417
2006 Soilleux EJ, Turley H, Tian YM, Pugh CW, Gatter KC, Harris AL. Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology. 47: 602-10. PMID 16324198 DOI: 10.1111/j.1365-2559.2005.02280.x  0.591
2006 Giatromanolaki A, Koukourakis MI, Sivridis E, Gatter KC, Harris AL, Banham AH. Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 19: 9-16. PMID 16258506 DOI: 10.1038/modpathol.3800494  0.533
2006 Williams CK, Li JL, Murga M, Harris AL, Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood. 107: 931-9. PMID 16219802 DOI: 10.1182/blood-2005-03-1000  0.663
2006 Lowndes SA, Adams A, Timms A, Middleton M, Hayward C, Reich SD, Mazar AP, Harris AL. Phase I study of ATN-224 in patients (pts) with advanced solid tumours Journal of Clinical Oncology. 24: 2065-2065. DOI: 10.1200/jco.2006.24.18_suppl.2065  0.732
2006 Doñate F, Lowndes S, Juarez J, Manuia M, Smith E, Liu N, Hayward C, Batuman O, Harris A, Mazar A. 132 POSTER Translation of in vitro markers of the anti-angiogenic and anti-tumor activity of the SOD1 inhibitor ATN-224 to clinical trials European Journal of Cancer Supplements. 4: 43. DOI: 10.1016/s1359-6349(06)70138-0  0.745
2006 Sainson RC, Harrington L, Shi W, Li JL, Williams C, Harris AL. Delta-Like 4 signaling regulates endothelial and surrounding cells' plasticity and cell fate determination during vascular development Vascular Pharmacology. 45: e43. DOI: 10.1016/j.vph.2006.08.185  0.783
2005 Ah-See ML, Burcombe RJ, Daley FM, Richman PI, Padhani AR, Bentzen SM, Fox SB, Harris AL, Makris A. Evaluation of tumour microvessel density & pericyte coverage index following neoadjuvant chemotherapy in primary breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 655. PMID 27946122 DOI: 10.1200/Jco.2005.23.16_Suppl.655  0.499
2005 Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, Malone PR, Harris AL. The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer Clinical Cancer Research. 11: 7658-7663. PMID 16278385 DOI: 10.1158/1078-0432.CCR-05-0460  0.813
2005 Winter SC, Shah KA, Campo L, Turley H, Leek R, Corbridge RJ, Cox GJ, Harris AL. Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma Clinical Cancer Research. 11: 7614-7620. PMID 16278379 DOI: 10.1158/1078-0432.CCR-05-1097  0.795
2005 Van den Eynden GG, Van der Auwera I, Van Laere SJ, Colpaert CG, Turley H, Harris AL, van Dam P, Dirix LY, Vermeulen PB, Van Marck EA. Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer. British Journal of Cancer. 93: 1128-36. PMID 16251878 DOI: 10.1038/Sj.Bjc.6602828  0.608
2005 Kato T, Prevo R, Steers G, Roberts H, Leek RD, Kimura T, Kameoka S, Nishikawa T, Kobayashi M, Jackson DG, Harris AL, Gatter KC, Pezzella F. A quantitative analysis of lymphatic vessels in human breast cancer, based on LYVE-1 immunoreactivity. British Journal of Cancer. 93: 1168-74. PMID 16251871 DOI: 10.1038/sj.bjc.6602844  0.736
2005 Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function Cancer Research. 65: 8690-8697. PMID 16204037 DOI: 10.1158/0008-5472.CAN-05-1208  0.811
2005 Van Laere S, Van der Auwera I, Van den Eynden GG, Fox SB, Bianchi F, Harris AL, van Dam P, Van Marck EA, Vermeulen PB, Dirix LY. Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis. Breast Cancer Research and Treatment. 93: 237-46. PMID 16172796 DOI: 10.1007/S10549-005-5157-Z  0.488
2005 Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Niederwieser D, Harris AL. Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. Journal of Cancer Research and Clinical Oncology. 131: 741-50. PMID 16136355 DOI: 10.1007/s00432-005-0024-1  0.79
2005 Ord JJ, Streeter EH, Roberts IS, Cranston D, Harris AL. Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer. British Journal of Cancer. 93: 346-54. PMID 16052224 DOI: 10.1038/sj.bjc.6602666  0.773
2005 Li JL, Harris AL. Notch signaling from tumor cells: a new mechanism of angiogenesis. Cancer Cell. 8: 1-3. PMID 16023591 DOI: 10.1016/j.ccr.2005.06.013  0.645
2005 Clement JH, Raida M, Sänger J, Bicknell R, Liu J, Naumann A, Geyer A, Waldau A, Hortschansky P, Schmidt A, Höffken K, Wölft S, Harris AL. Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. International Journal of Oncology. 27: 401-7. PMID 16010421  0.704
2005 Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and Cellular Biology. 25: 5675-86. PMID 15964822 DOI: 10.1128/Mcb.25.13.5675-5686.2005  0.797
2005 Ord JJ, Streeter E, Jones A, Le Monnier K, Cranston D, Crew J, Joel SP, Rogers MA, Banks RE, Roberts IS, Harris AL. Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma. British Journal of Cancer. 92: 2140-7. PMID 15928663 DOI: 10.1038/sj.bjc.6602650  0.719
2005 Couvelard A, O'Toole D, Leek R, Turley H, Sauvanet A, Degott C, Ruszniewski P, Belghiti J, Harris AL, Gatter K, Pezzella F. Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas. Histopathology. 46: 668-76. PMID 15910598 DOI: 10.1111/j.1365-2559.2005.02160.x  0.789
2005 Leek RD, Stratford I, Harris AL. The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway. Cancer Research. 65: 4147-52. PMID 15899805 DOI: 10.1158/0008-5472.CAN-04-2184  0.612
2005 Raida M, Clement JH, Ameri K, Han C, Leek RD, Harris AL. Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. International Journal of Oncology. 26: 1465-70. PMID 15870857  0.831
2005 Brown NS, Streeter EH, Jones A, Harris AL, Bicknell R. Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma. British Journal of Cancer. 92: 1696-701. PMID 15841086 DOI: 10.1038/sj.bjc.6602522  0.768
2005 Winter SC, Corbridge RJ, Cox GJ, Harris AL. Hypoxia and anaemia in head and neck squamous cell carcinoma - mechanisms of therapy failure and provision of new therapeutic targets. Clinical Otolaryngology : Official Journal of Ent-Uk ; Official Journal of Netherlands Society For Oto-Rhino-Laryngology & Cervico-Facial Surgery. 30: 99-104. PMID 15839859 DOI: 10.1111/j.1365-2273.2004.00946.x  0.549
2005 Campo L, Turley H, Han C, Pezzella F, Gatter KC, Harris AL, Fox SB. Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival. The Journal of Pathology. 205: 585-91. PMID 15776477 DOI: 10.1002/path.1740  0.766
2005 Braybrooke JP, Slade A, Deplanque G, Harrop R, Madhusudan S, Forster MD, Gibson R, Makris A, Talbot DC, Steiner J, White L, Kan O, Naylor S, Carroll MW, Kingsman SM, ... Harris AL, et al. Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1512-20. PMID 15746054 DOI: 10.1158/1078-0432.CCR-04-0155  0.687
2005 Boddy JL, Gal S, Malone PR, Harris AL, Wainscoat JS. Prospective study of quantitation of plasma DNA levels in the diagnosis of malignant versus benign prostate disease. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1394-9. PMID 15746038 DOI: 10.1158/1078-0432.CCR-04-1237  0.705
2005 Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL. Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma. Neoplasia (New York, N.Y.). 7: 1-6. PMID 15736311 DOI: 10.1593/neo.04373  0.539
2005 Pillai G, Cook N, Turley H, Leek RD, Blasquez C, Pezzella F, Harris AL, Gatter KC. The expression and cellular localization of phosphorylated VEGFR2 in lymphoma and non-neoplastic lymphadenopathy: an immunohistochemical study. Histopathology. 46: 209-16. PMID 15693894 DOI: 10.1111/j.1365-2559.2005.02081.x  0.779
2005 Carroll VA, Nikitenko LL, Bicknell R, Harris AL. Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2 Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 736-741. PMID 15692103 DOI: 10.1161/01.ATV.0000157980.15710.2b  0.537
2005 Preusser M, Wolfsberger S, Haberler C, Breitschopf H, Czech T, Slavc I, Harris AL, Acker T, Budka H, Hainfellner JA. Vascularization and expression of hypoxia-related tissue factors in intracranial ependymoma and their impact on patient survival. Acta Neuropathologica. 109: 211-6. PMID 15614581 DOI: 10.1007/S00401-004-0938-8  0.3
2005 Hu J, Bianchi F, Ferguson M, Cesario A, Margaritora S, Granone P, Goldstraw P, Tetlow M, Ratcliffe C, Nicholson AG, Harris A, Gatter K, Pezzella F. Gene expression signature for angiogenic and nonangiogenic non-small-cell lung cancer. Oncogene. 24: 1212-9. PMID 15592519 DOI: 10.1038/sj.onc.1208242  0.57
2005 Giatromanolaki A, Koukourakis MI, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, Sivridis E. c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7972-7. PMID 15585632 DOI: 10.1158/1078-0432.CCR-04-1068  0.526
2005 Fox SB, Harris AL. Histological quantitation of tumour angiogenesis. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 112: 413-30. PMID 15563306 DOI: 10.1111/j.1600-0463.2004.apm11207-0803.x  0.465
2005 Couvelard A, O'Toole D, Turley H, Leek R, Sauvanet A, Degott C, Ruszniewski P, Belghiti J, Harris AL, Gatter K, Pezzella F. Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. British Journal of Cancer. 92: 94-101. PMID 15558070 DOI: 10.1038/sj.bjc.6602245  0.805
2005 Bacon AL, Harris AL. Hypoxia-inducible factors and hypoxic cell death in tumour physiology. Annals of Medicine. 36: 530-9. PMID 15513303 DOI: 10.1080/07853890410018231  0.766
2005 Smith CL, Dunbar PR, Mirza F, Palmowski MJ, Shepherd D, Gilbert SC, Coulie P, Schneider J, Hoffman E, Hawkins R, Harris AL, Cerundolo V. Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence. International Journal of Cancer. 113: 259-66. PMID 15386406 DOI: 10.1002/Ijc.20569  0.424
2005 Giatromanolaki A, Koukourakis MI, Sowter HM, Sivridis E, Gibson S, Gatter KC, Harris AL. BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5566-71. PMID 15328198 DOI: 10.1158/1078-0432.CCR-04-0076  0.802
2005 Boddy J, Fox S, Cheng H, Hurley H, Brown P, Malone P, Banham A, Harris A. 885Co-expression of the forkhead transcription factor, FOXPI with the androgen receptor in human prostate cancer, support its role as a potential co-regulator of this receptor European Urology Supplements. 4: 224. DOI: 10.1016/S1569-9056(05)80889-9  0.759
2005 Chong TW, Salio M, Hermans IF, Harris AL, Cerundolo V. Analysis of renal cell cancer tumour antigen carbonic anhydrase 9 specific cytotoxic T lymphocytes from a healthy HLA-A2 donor The Journal of Urology. 173: 96-96. DOI: 10.1016/S0022-5347(18)34605-6  0.551
2005 Boddy JL, Fox SB, Cheng H, Hurley H, Brown P, Malone PR, Harris AL. 237: Expression of the Androgen Receptor in Prostate Cancer is related to Vascular Endothelial Growth Factor and Hypoxia Inducible Factors 1: and 2 Journal of Urology. 173: 65-65. DOI: 10.1016/s0022-5347(18)34502-6  0.781
2005 Merajver S, Harris A. Introduction on Angiogenesis in Breast Cancer Journal of Mammary Gland Biology and Neoplasia. 10: 281-282. DOI: 10.1007/S10911-006-9000-X  0.323
2004 Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Harris AL. Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 9531. PMID 28016826 DOI: 10.1200/jco.2004.22.14_suppl.9531  0.778
2004 Lowndes SA, Harris AL. Copper chelation as an antiangiogenic therapy Oncology Research. 14: 529-539. PMID 15666995 DOI: 10.3727/0965040042707952  0.75
2004 Silk JD, Hermans IF, Gileadi U, Chong TW, Shepherd D, Salio M, Mathew B, Schmidt RR, Lunt SJ, Williams KJ, Stratford IJ, Harris AL, Cerundolo V. Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy. The Journal of Clinical Investigation. 114: 1800-11. PMID 15599405 DOI: 10.1172/Jci200422046  0.789
2004 Van der Auwera I, Van Laere SJ, Van den Eynden GG, Benoy I, van Dam P, Colpaert CG, Fox SB, Turley H, Harris AL, Van Marck EA, Vermeulen PB, Dirix LY. Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7965-71. PMID 15585631 DOI: 10.1158/1078-0432.Ccr-04-0063  0.678
2004 Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Research. 64: 6563-70. PMID 15374969 DOI: 10.1158/0008-5472.CAN-03-3176  0.807
2004 Robertson N, Potter C, Harris AL. Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Research. 64: 6160-5. PMID 15342400 DOI: 10.1158/0008-5472.CAN-03-2224  0.797
2004 Fox SB, Bragança J, Turley H, Campo L, Han C, Gatter KC, Bhattacharya S, Harris AL. CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. Cancer Research. 64: 6075-81. PMID 15342390 DOI: 10.1158/0008-5472.Can-04-0708  0.713
2004 Chakrabarti J, Turley H, Campo L, Han C, Harris AL, Gatter KC, Fox SB. The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers. British Journal of Cancer. 91: 954-8. PMID 15328513 DOI: 10.1038/sj.bjc.6602059  0.713
2004 Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. The Journal of Biological Chemistry. 279: 38458-65. PMID 15247232 DOI: 10.1074/Jbc.M406026200  0.751
2004 Turley H, Wykoff CC, Troup S, Watson PH, Gatter KC, Harris AL. The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours. The Journal of Pathology. 203: 808-13. PMID 15221940 DOI: 10.1002/path.1585  0.711
2004 Knowles HJ, Tian YM, Mole DR, Harris AL. Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circulation Research. 95: 162-9. PMID 15192023 DOI: 10.1161/01.RES.0000134924.89412.70  0.683
2004 Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR. Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy Clinical Cancer Research. 10: 3863-3870. PMID 15173095 DOI: 10.1158/1078-0432.CCR-03-0237  0.583
2004 Fox SB, Brown P, Han C, Ashe S, Leek RD, Harris AL, Banham AH. Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3521-7. PMID 15161711 DOI: 10.1158/1078-0432.CCR-03-0461  0.715
2004 Stephen RL, Gustafsson MC, Jarvis M, Tatoud R, Marshall BR, Knight D, Ehrenborg E, Harris AL, Wolf CR, Palmer CN. Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Research. 64: 3162-70. PMID 15126355 DOI: 10.1158/0008-5472.CAN-03-2760  0.306
2004 Koukourakis MI, Giatromanolaki A, Sivridis E, Pastorek J, Karapantzos I, Gatter KC, Harris AL. Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics. 59: 67-71. PMID 15093900 DOI: 10.1016/j.ijrobp.2003.10.016  0.515
2004 Knowles H, Leek R, Harris AL. Macrophage infiltration and angiogenesis in human malignancy. Novartis Foundation Symposium. 256: 189-200; discussion . PMID 15027491  0.776
2004 Fox SB, Turley H, Cheale M, Blázquez C, Roberts H, James N, Cook N, Harris A, Gatter K. Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus. The Journal of Pathology. 202: 313-20. PMID 14991896 DOI: 10.1002/path.1520  0.666
2004 Madhusudan S, Deplanque G, Braybrooke JP, Cattell E, Taylor M, Price P, Tsaloumas MD, Moore N, Huson SM, Adams C, Frith P, Scigalla P, Harris AL. Antiangiogenic therapy for von Hippel-Lindau disease. Jama. 291: 943-4. PMID 14982909 DOI: 10.1001/JAMA.291.8.943  0.628
2004 Sowter HM, Ferguson M, Pym C, Watson P, Fox SB, Han C, Harris AL. Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade. The Journal of Pathology. 201: 573-80. PMID 14648660 DOI: 10.1002/path.1486  0.776
2004 Ameri K, Lewis CE, Raida M, Sowter H, Hai T, Harris AL. Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. Blood. 103: 1876-82. PMID 14604972 DOI: 10.1182/Blood-2003-06-1859  0.831
2004 Giatromanolaki A, Sivridis E, Kouskoukis C, Gatter KC, Harris AL, Koukourakis MI. Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Research. 13: 493-501. PMID 14512791 DOI: 10.1097/00008390-200310000-00008  0.55
2004 Stewart M, Turley H, Cook N, Pezzella F, Pillai G, Ogilvie D, Cartlidge S, Paterson D, Copley C, Kendrew J, Barnes C, Harris AL, Gatter KC. The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study. Histopathology. 43: 33-9. PMID 12823710 DOI: 10.1046/j.1365-2559.2003.01644.x  0.7
2004 Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Harris AL. Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis Journal of Clinical Oncology. 22: 9531-9531. DOI: 10.1200/jco.2004.22.90140.9531  0.742
2004 Silk JD, Hermans IF, Gileadi U, Chong TW, Shepherd D, Salio M, Mathew B, Schmidt RR, Lunt SJ, Williams KJ, Stratford IJ, Harris AL, Cerundolo V. Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy Journal of Clinical Investigation. 114: 1800-1811. DOI: 10.1172/JCI200422046  0.515
2004 Boddy J, Gal S, Harris A, Wainscoat J, Malone P. 85 The diagnostic value of cell free DNA levels in prostate cancer and a reminder on the importance of sample selection European Urology Supplements. 3: 24. DOI: 10.1016/S1569-9056(04)90087-5  0.712
2004 Ord JJ, Cranston D, Harris AL, Campo L, Turley H, Allen P, Fox S, Davies DR. 773: C-KIT and CK7 Immunohistochemistry in the Differential Diagnosis of Renal Cell Carcinoma, A Study of 111 Cases Journal of Urology. 171: 205-205. DOI: 10.1016/s0022-5347(18)38022-4  0.6
2003 Hermans IF, Chong TW, Palmowski MJ, Harris AL, Cerundolo V. Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model. Cancer Research. 63: 8408-13. PMID 14679003  0.794
2003 Hermans IF, Silk JD, Gileadi U, Salio M, Mathew B, Ritter G, Schmidt R, Harris AL, Old L, Cerundolo V. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 5140-7. PMID 14607913 DOI: 10.4049/Jimmunol.171.10.5140  0.559
2003 Braybrooke JP, Levitt NC, Joel S, Davis T, Madhusudan S, Turley H, Wilner S, Harris AL, Talbot DC. Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase IIalpha expression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 4682-8. PMID 14581337  0.601
2003 Winters ZE, Leek RD, Bradburn MJ, Norbury CJ, Harris AL. Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Research : Bcr. 5: R242-9. PMID 14580260 DOI: 10.1186/Bcr654  0.829
2003 Koukourakis MI, Giatromanolaki A, Chong W, Simopoulos C, Polychronidis A, Sivridis E, Harris AL. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemotherapy and Pharmacology. 53: 8-14. PMID 14574457 DOI: 10.1007/s00280-003-0691-z  0.495
2003 Colpaert CG, Vermeulen PB, Fox SB, Harris AL, Dirix LY, Van Marck EA. The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis. Breast Cancer Research and Treatment. 81: 137-47. PMID 14572156 DOI: 10.1023/A:1025702330207  0.477
2003 Turner HE, Harris AL, Melmed S, Wass JA. Angiogenesis in endocrine tumors. Endocrine Reviews. 24: 600-32. PMID 14570746 DOI: 10.1210/er.2002-0008  0.583
2003 Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Research. 63: 6130-4. PMID 14559790  0.819
2003 Tomes L, Emberley E, Niu Y, Troup S, Pastorek J, Strange K, Harris A, Watson PH. Necrosis and hypoxia in invasive breast carcinoma Breast Cancer Research and Treatment. 81: 61-69. PMID 14531498 DOI: 10.1023/A:1025476722493  0.33
2003 Kaklamanis L, Kakolyris S, Turley H, Koukourakis M, Biddolph S, Gatter KC, Harris AL. Neoplastic stroma and epithelium show up-regulation of platelet-derived endothelial cell growth factor/thymidine phosphorylase in colorectal carcinomas but not adenomas. Angiogenesis. 2: 49-55. PMID 14517375 DOI: 10.1023/A:1009002426554  0.614
2003 Adam PJ, Berry J, Loader JA, Tyson KL, Craggs G, Smith P, De Belin J, Steers G, Pezzella F, Sachsenmeir KF, Stamps AC, Herath A, Sim E, O'Hare MJ, Harris AL, et al. Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Molecular Cancer Research : McR. 1: 826-35. PMID 14517345  0.611
2003 Koukourakis MI, Giatromanolaki A, Brekken RA, Sivridis E, Gatter KC, Harris AL, Sage EH. Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients. Cancer Research. 63: 5376-80. PMID 14500371  0.563
2003 Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proceedings of the National Academy of Sciences of the United States of America. 100: 10393-8. PMID 12917485 DOI: 10.1073/Pnas.1732912100  0.462
2003 Giatromanolaki A, Sivridis E, Maltezos E, Athanassou N, Papazoglou D, Gatter KC, Harris AL, Koukourakis MI. Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis. Arthritis Research & Therapy. 5: R193-201. PMID 12823854 DOI: 10.1186/ar756  0.495
2003 Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. The Journal of Pathology. 200: 222-8. PMID 12754744 DOI: 10.1002/path.1330  0.764
2003 Williams CS, Leek RD, Robson AM, Banerji S, Prevo R, Harris AL, Jackson DG. Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer. The Journal of Pathology. 200: 195-206. PMID 12754740 DOI: 10.1002/path.1343  0.797
2003 Kuenen BC, Tabernero J, Baselga J, Cavalli F, Pfanner E, Conte PF, Seeber S, Madhusudan S, Deplanque G, Huisman H, Scigalla P, Hoekman K, Harris AL. Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 1648-55. PMID 12738717  0.697
2003 Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Research. 63: 1764-8. PMID 12702559  0.804
2003 Watson PH, Chia SK, Wykoff CC, Han C, Leek RD, Sly WS, Gatter KC, Ratcliffe P, Harris AL. Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma. British Journal of Cancer. 88: 1065-70. PMID 12671706 DOI: 10.1038/Sj.Bjc.6600796  0.635
2003 Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P, Fox SB, Harris AL, van Marck EA. Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression. British Journal of Cancer. 88: 718-25. PMID 12618881 DOI: 10.1038/sj.bjc.6600807  0.533
2003 Giatromanolaki A, Sivridis E, Maltezos E, Papazoglou D, Simopoulos C, Gatter KC, Harris AL, Koukourakis MI. Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease. Journal of Clinical Pathology. 56: 209-13. PMID 12610101 DOI: 10.1136/jcp.56.3.209  0.473
2003 Swinson DE, Jones JL, Richardson D, Wykoff C, Turley H, Pastorek J, Taub N, Harris AL, O'Byrne KJ. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 21: 473-82. PMID 12560438 DOI: 10.1200/JCO.2003.11.132  0.692
2003 Giatromanolaki A, Sivridis E, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, Koukourakis MI. Differential assessment of angiogenic activity and of vascular survival ability (VSA) in breast cancer. Clinical & Experimental Metastasis. 19: 673-9. PMID 12553372 DOI: 10.1023/A:1021354028685  0.559
2003 Propper DJ, Chao D, Braybrooke JP, Bahl P, Thavasu P, Balkwill F, Turley H, Dobbs N, Gatter K, Talbot DC, Harris AL, Ganesan TS. Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 84-92. PMID 12538455  0.565
2003 Leek RD, Harris AL. Tumor-associated macrophages in breast cancer. Journal of Mammary Gland Biology and Neoplasia. 7: 177-89. PMID 12463738 DOI: 10.1023/A:1020304003704  0.643
2003 Giatromanolaki A, Sivridis E, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, Koukourakis MI. Thymidine phosphorylase expression in gallbladder adenocarcinomas. International Journal of Surgical Pathology. 10: 181-8. PMID 12232571 DOI: 10.1177/106689690201000303  0.531
2003 Boddy J, Gal S, Malone P, Harris A, Wainscoat J. Investigating the relationship between plasma DNA levels and prostate cancer European Urology Supplements. 2: 84. DOI: 10.1016/S1569-9056(03)90445-3  0.701
2003 Giatromanolaki A, Sivridis E, Kouskoukis C, Gatter K, Harris A, Koukourakis M. 839 Hypoxia-inducible factors 1a and 2a in skin malignant melanomas European Journal of Cancer Supplements. 1: S252-S253. DOI: 10.1016/S1359-6349(03)90865-2  0.394
2003 Harris AL. Angiogenesis as a new target for cancer control European Journal of Cancer, Supplement. 1: 1-12. DOI: 10.1016/S1359-6349(03)00007-7  0.337
2002 Adeyinka A, Emberley E, Niu Y, Snell L, Murphy LC, Sowter H, Wykoff CC, Harris AL, Watson PH. Analysis of gene expression in ductal carcinoma in situ of the breast Clinical Cancer Research. 8: 3788-3795. PMID 12473591  0.793
2002 Chong TW, Horwitz LD, Moore JW, Sowter HM, Harris AL. A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines. Cancer Research. 62: 6924-7. PMID 12460908  0.83
2002 Currie MJ, Gunningham SP, Turner K, Han C, Scott PA, Robinson BA, Chong W, Harris AL, Fox SB. Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. The Journal of Pathology. 198: 502-10. PMID 12434420 DOI: 10.1002/path.1228  0.81
2002 Collingridge DR, Carroll VA, Glaser M, Aboagye EO, Osman S, Hutchinson OC, Barthel H, Luthra SK, Brady F, Bicknell R, Price P, Harris AL. The development of [(124)I]iodinated-VG76e: a novel tracer for imaging vascular endothelial growth factor in vivo using positron emission tomography. Cancer Research. 62: 5912-9. PMID 12384557  0.57
2002 Wilson KS, Roberts H, Leek R, Harris AL, Geradts J. Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. The American Journal of Pathology. 161: 1171-85. PMID 12368191 DOI: 10.1016/S0002-9440(10)64394-5  0.657
2002 Goonewardene TI, Sowter HM, Harris AL. Hypoxia-induced pathways in breast cancer. Microscopy Research and Technique. 59: 41-8. PMID 12242695 DOI: 10.1002/jemt.10175  0.781
2002 Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer. 95: 1055-63. PMID 12209691 DOI: 10.1002/cncr.10774  0.501
2002 Hui EP, Chan AT, Pezzella F, Turley H, To KF, Poon TC, Zee B, Mo F, Teo PM, Huang DP, Gatter KC, Johnson PJ, Harris AL. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2595-604. PMID 12171890  0.71
2002 Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M, Beliën JA, de Waal RM, Van Marck E, Magnani E, Weidner N, Harris AL, Dirix LY. Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. European Journal of Cancer (Oxford, England : 1990). 38: 1564-79. PMID 12142044  0.383
2002 Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos C, Turley H, Talks K, Gatter KC, Harris AL. Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics. 53: 1192-202. PMID 12128120 DOI: 10.1016/S0360-3016(02)02848-1  0.827
2002 Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell. 1: 459-68. PMID 12124175 DOI: 10.1016/S1535-6108(02)00071-5  0.802
2002 Streeter EH, Harris AL. Angiogenesis in bladder cancer--prognostic marker and target for future therapy. Surgical Oncology. 11: 85-100. PMID 12031871 DOI: 10.1016/S0960-7404(02)00013-0  0.758
2002 Turner KJ, Moore JW, Jones A, Taylor CF, Cuthbert-Heavens D, Han C, Leek RD, Gatter KC, Maxwell PH, Ratcliffe PJ, Cranston D, Harris AL. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Research. 62: 2957-61. PMID 12019178  0.789
2002 Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Research. 62: 2493-7. PMID 11980639  0.739
2002 Sivridis E, Giatromanolaki A, Anastasiadis P, Georgiou L, Gatter KC, Harris AL, Bicknell R, Koukourakis MI. Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas. The Journal of Pathology. 196: 416-22. PMID 11920737 DOI: 10.1002/path.1060  0.545
2002 Fox SB, Gasparini G, Harris AL. Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. The Lancet. Oncology. 2: 278-89. PMID 11905783 DOI: 10.1016/S1470-2045(00)00323-5  0.496
2002 Pezzella F, Harris AL, Gatter KC. Ways of escape: are all tumours angiogenic? Histopathology. 39: 551-3. PMID 11903570 DOI: 10.1046/j.1365-2559.2001.01027.x  0.515
2002 Harris AL. Hypoxia - A key regulatory factor in tumour growth Nature Reviews Cancer. 2: 38-47. PMID 11902584  0.312
2002 Leek RD, Talks KL, Pezzella F, Turley H, Campo L, Brown NS, Bicknell R, Taylor M, Gatter KC, Harris AL. Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Research. 62: 1326-9. PMID 11888900  0.828
2002 Beasley NJ, Prevo R, Banerji S, Leek RD, Moore J, van Trappen P, Cox G, Harris AL, Jackson DG. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Research. 62: 1315-20. PMID 11888898  0.637
2002 Jones A, Fujiyama C, Turner K, Cranston D, Williams K, Stratford I, Bicknell R, Harris AL. Role of thymidine phosphorylase in an in vitro model of human bladder cancer invasion. The Journal of Urology. 167: 1482-6. PMID 11832774  0.805
2002 Griffiths JR, McSheehy PMJ, Robinson SP, Troy H, Chung YL, Leek RD, Williams KJ, Stratford IJ, Harris AL, Stubbs M. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway Cancer Research. 62: 688-695. PMID 11830521  0.618
2002 Giatromanolaki A, Sivridis E, Brekken R, Thorpe PE, Anastasiadis P, Gatter KC, Harris AL, Koukourakis MI. The angiogenic "vascular endothelial growth factor/flk-1(KDR) receptor" pathway in patients with endometrial carcinoma: prognostic and therapeutic implications. Cancer. 92: 2569-77. PMID 11745191 DOI: 10.1002/1097-0142(20011115)92:10<2569::AID-CNCR1609>3.0.CO;2-3  0.512
2002 Kelly CE, Leek RD, Byrne HM, Cox SM, Harris AL, Lewis CE. Modelling macrophage infiltration into avascular tumours Journal of Theoretical Medicine. 4: 21-38. DOI: 10.1080/10273660290015242  0.538
2001 Winters ZE, Hunt NC, Bradburn MJ, Royds JA, Turley H, Harris AL, Norbury CJ. Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis. European Journal of Cancer (Oxford, England : 1990). 37: 2405-12. PMID 11720835 DOI: 10.1016/S0959-8049(01)00327-6  0.595
2001 O'Byrne KJ, Cox G, Swinson D, Richardson D, Edwards JG, Lolljee J, Andi A, Koukourakis MI, Giatromanolaki A, Gatter K, Harris AL, Waller D, Jones JL. Towards a biological staging model for operable non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 34: S83-9. PMID 11720747 DOI: 10.1016/S0169-5002(01)00352-X  0.515
2001 Knowles HJ, Harris AL. Hypoxia and tumorigenesis Breast Cancer Research. 3: 318-322. PMID 11597321 DOI: 10.1186/bcr314  0.677
2001 Fox SB, Taylor M, Grøndahl-Hansen J, Kakolyris S, Gatter KC, Harris AL. Plasminogen activator inhibitor-1 as a measure of vascular remodelling in breast cancer. The Journal of Pathology. 195: 236-43. PMID 11592104 DOI: 10.1002/path.931  0.504
2001 Chia SK, Wykoff CC, Watson PH, Han C, Leek RD, Pastorek J, Gatter KC, Ratcliffe P, Harris AL. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 19: 3660-8. PMID 11504747 DOI: 10.1200/Jco.2001.19.16.3660  0.634
2001 Giatromanolaki A, Koukourakis MI, Sivridis E, Thorpe PE, Brekken RA, Konstantinos S, Fountzilas G, Gatter KC, Harris AL. Tumor specific activation of the VEGF/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas. Clinical & Experimental Metastasis. 18: 313-9. PMID 11448062 DOI: 10.1023/A:1011083121295  0.549
2001 Giatromanolaki A, Sivridis E, Athanassou N, Zois E, Thorpe PE, Brekken RA, Gatter KC, Harris AL, Koukourakis IM, Koukourakis MI. The angiogenic pathway "vascular endothelial growth factor/flk-1(KDR)-receptor" in rheumatoid arthritis and osteoarthritis. The Journal of Pathology. 194: 101-8. PMID 11329148 DOI: 10.1002/path.842  0.483
2001 Gunningham SP, Currie MJ, Han C, Robinson BA, Scott PA, Harris AL, Fox SB. VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis. The Journal of Pathology. 193: 325-32. PMID 11241411 DOI: 10.1002/path.814  0.507
2000 Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. The American Journal of Pathology. 157: 411-21. PMID 10934146 DOI: 10.1016/S0002-9440(10)64554-3  0.779
2000 Braybrooke JP, Propper DJ, O'Byrne KJ, Koukourakis MI, Patterson AV, Houlbrook S, Love SD, Varcoe S, Taylor M, Ganesan TS, Talbot DC, Harris AL. Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha British Journal of Cancer. 83: 219-224. PMID 10901374 DOI: 10.1054/bjoc.2000.1230  0.436
2000 Jones A, Fujiyama C, Turner K, Fuggle S, Cranston D, Turley H, Valtola R, Bicknell R, Harris AL. Angiogenesis and lymphangiogenesis in stage 1 germ cell tumours of the testis. Bju International. 86: 80-6. PMID 10886088 DOI: 10.1046/j.1464-410x.2000.00660.x  0.556
2000 Kakolyris S, Fox SB, Koukourakis M, Giatromanolaki A, Brown N, Leek RD, Taylor M, Leigh IM, Gatter KC, Harris AL. Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39. British Journal of Cancer. 82: 844-51. PMID 10732757 DOI: 10.1054/bjoc.1999.1010  0.517
2000 Leek RD, Hunt NC, Landers RJ, Lewis CE, Royds JA, Harris AL. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. The Journal of Pathology. 190: 430-6. PMID 10699991 DOI: 10.1002/(SICI)1096-9896(200003)190:4<430::AID-PATH538>3.0.CO;2-6  0.668
2000 Sivridis E, Giatromanolaki A, Koukourakis MI, Bicknell R, Harris AL, Gatter KC. Thymidine phosphorylase expression in endometrial carcinomas. Clinical & Experimental Metastasis. 17: 445-50. PMID 10651312 DOI: 10.1023/A:1006603709248  0.553
2000 Fox SB, Gatter KC, Leek RD, Harris AL, Chew KL, Mayall BH, Moore DH. More about: Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. Journal of the National Cancer Institute. 92: 161-2. PMID 10639519 DOI: 10.1093/jnci/92.2.161  0.686
2000 Crew JP, Fuggle S, Bicknell R, Cranston DW, de Benedetti A, Harris AL. Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression. British Journal of Cancer. 82: 161-6. PMID 10638984 DOI: 10.1054/bjoc.1999.0894  0.307
1999 Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Jiles C, Krammer B, Gatter KC, Harris AL. bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer Clinical and Experimental Metastasis. 17: 545-554. PMID 10845553 DOI: 10.1023/A:1006780710148  0.535
1999 Giatromanolaki A, Stathopoulos GP, Tsiompanou E, Tsiobanou E, Papadimitriou C, Georgoulias V, Gatter KC, Harris AL, Koukourakis MI. Combined role of tumor angiogenesis, bcl-2, and p53 expression in the prognosis of patients with colorectal carcinoma. Cancer. 86: 1421-30. PMID 10526268 DOI: 10.1002/(SICI)1097-0142(19991015)86:8<1421::AID-CNCR6>3.0.CO;2-X  0.468
1999 O'Byrne KJ, Philip PA, Propper DJ, Braybrooke JP, Saunders MP, Bates NP, Taylor MA, Madigan D, Ganesan TS, Talbot DC, Harris AL. A phase II study of the modulation of 5-fluorouracil and folinic acid with high-dose infusional hydroxyurea in metastatic colorectal carcinoma. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 10: 981-3. PMID 10509162 DOI: 10.1023/A:1008330302535  0.458
1999 Smith K, Fox SB, Whitehouse R, Taylor M, Greenall M, Clarke J, Harris AL. Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 10: 707-13. PMID 10442194 DOI: 10.1023/A:1008303614441  0.524
1999 Arapandoni-Dadioti P, Giatromanolaki A, Trihia H, Harris AL, Koukourakis MI. Angiogenesis in ductal breast carcinoma. Comparison of microvessel density between primary tumour and lymph node metastasis. Cancer Letters. 137: 145-50. PMID 10374835 DOI: 10.1016/S0304-3835(98)00343-7  0.447
1999 Turley H, Scott PA, Watts VM, Bicknell R, Harris AL, Gatter KC. Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. The Journal of Pathology. 186: 313-8. PMID 10211122 DOI: 10.1002/(SICI)1096-9896(1998110)186:3<313::AID-PATH188>3.0.CO;2-X  0.58
1999 O'Byrne KJ, Dobbs N, Propper DJ, Braybrooke JP, Koukourakis MI, Mitchel K, Woodhull J, Talbot DC, Schally AV, Harris AL. Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer British Journal of Cancer. 79: 1413-1418. PMID 10188884 DOI: 10.1038/Sj.Bjc.6690226  0.493
1999 Patterson A, Harris AL. Molecular chemotherapy for breast cancer Drugs and Aging. 14: 75-90. PMID 10084362 DOI: 10.2165/00002512-199914020-00001  0.319
1999 Leek RD, Landers RJ, Harris AL, Lewis CE. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. British Journal of Cancer. 79: 991-5. PMID 10070902 DOI: 10.1038/sj.bjc.6690158  0.628
1999 Ellis MJ, Jenkins S, Hanfelt J, Redington ME, Taylor M, Leek R, Siddle K, Harris A. Insulin-like growth factors in human breast cancer. Breast Cancer Research and Treatment. 52: 175-84. PMID 10066081 DOI: 10.1023/A:1006127621512  0.637
1999 Giatromanolaki A, Fountzilas G, Koukourakis MI, Arapandoni P, Theologi V, Kakolyris S, Georgoulias V, Harris AL, Gatter KC. Neo-angiogenesis in locally advanced squamous cell head and neck cancer correlates with thymidine phosphorylase expression and p53 nuclear oncoprotein accumulation. Clinical & Experimental Metastasis. 16: 665-72. PMID 9932613 DOI: 10.1023/A:1006554512338  0.526
1999 Guddo F, Giatromanolaki A, Koukourakis MI, Reina C, Vignola AM, Chlouverakis G, Hilkens J, Gatter KC, Harris AL, Bonsignore G. MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients. Journal of Clinical Pathology. 51: 667-71. PMID 9930070 DOI: 10.1136/jcp.51.9.667  0.505
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