Helen Knowles - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Knowles HJ. Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function. Scientific Reports. 10: 21072. PMID 33273561 DOI: 10.1038/s41598-020-78003-z  0.301
2017 Knowles HJ. Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease. Frontiers in Endocrinology. 8: 80. PMID 28458654 DOI: 10.3389/fendo.2017.00080  0.301
2017 Hulley PA, Bishop T, Vernet A, Schneider JE, Edwards JR, Athanasou NA, Knowles HJ. Hypoxia-Inducible Factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. The Journal of Pathology. PMID 28418093 DOI: 10.1002/path.4906  0.364
2017 Knowles HJ. Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone. Calcified Tissue International. 100: 382-391. PMID 28097375 DOI: 10.1007/s00223-016-0228-1  0.327
2012 Taylor RM, Kashima TG, Knowles HJ, Athanasou NA. VEGF, FLT3 ligand, PlGF and HGF can substitute for M-CSF to induce human osteoclast formation: implications for giant cell tumour pathobiology. Laboratory Investigation; a Journal of Technical Methods and Pathology. 92: 1398-406. PMID 22906984 DOI: 10.1038/labinvest.2012.108  0.315
2011 Taylor R, Knowles HJ, Athanasou NA. Ewing sarcoma cells express RANKL and support osteoclastogenesis. The Journal of Pathology. 225: 195-202. PMID 21547906 DOI: 10.1002/path.2869  0.333
2010 Knowles HJ, Cleton-Jansen AM, Korsching E, Athanasou NA. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4648-59. PMID 20667978 DOI: 10.1096/Fj.10-162230  0.378
2010 Knowles HJ, Schaefer KL, Dirksen U, Athanasou NA. Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. Bmc Cancer. 10: 372. PMID 20637078 DOI: 10.1186/1471-2407-10-372  0.445
2010 Benson RT, McDonnell SM, Knowles HJ, Rees JL, Carr AJ, Hulley PA. Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis. The Journal of Bone and Joint Surgery. British Volume. 92: 448-53. PMID 20190320 DOI: 10.1302/0301-620X.92B3.23074  0.379
2010 Knowles H, Cleton-Jansen A, Korsching E, Athanasou N. Hypoxia-Inducible Factor (HIF) regulates Osteoclast-Mediated Bone Resorption via Angiopoietin-like 4 (ANGPTL4) Bone. 46. DOI: 10.1016/J.Bone.2010.01.151  0.331
2009 Knowles HJ, Athanasou NA. Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis. The Journal of Pathology. 218: 256-64. PMID 19291710 DOI: 10.1002/path.2534  0.356
2009 Knowles HJ, Athanasou NA. Canonical and non-canonical pathways of osteoclast formation. Histology and Histopathology. 24: 337-46. PMID 19130404 DOI: 10.14670/HH-24.337  0.304
2008 Knowles HJ, Athanasou NA. Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF. The Journal of Pathology. 215: 56-66. PMID 18283716 DOI: 10.1002/path.2319  0.553
2007 Knowles HJ, Harris AL. Macrophages and the hypoxic tumour microenvironment. Frontiers in Bioscience : a Journal and Virtual Library. 12: 4298-314. PMID 17485376 DOI: 10.2741/2389  0.45
2006 Knowles HJ, Mole DR, Ratcliffe PJ, Harris AL. Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Research. 66: 2600-7. PMID 16510578 DOI: 10.1158/0008-5472.Can-05-2351  0.628
2006 Knowles HJ, te Poele RH, Te Poole R, Workman P, Harris AL. Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochemical Pharmacology. 71: 646-56. PMID 16386710 DOI: 10.1016/j.bcp.2005.11.019  0.497
2004 Knowles HJ, Tian YM, Mole DR, Harris AL. Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circulation Research. 95: 162-9. PMID 15192023 DOI: 10.1161/01.RES.0000134924.89412.70  0.549
2004 Knowles H, Leek R, Harris AL. Macrophage infiltration and angiogenesis in human malignancy. Novartis Foundation Symposium. 256: 189-200; discussion . PMID 15027491  0.582
2003 Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Research. 63: 1764-8. PMID 12702559  0.528
2001 Knowles HJ, Harris AL. Hypoxia and tumorigenesis Breast Cancer Research. 3: 318-322. PMID 11597321 DOI: 10.1186/bcr314  0.528
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