Helen Knowles - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 

20/64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Knowles HJ. Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function. Scientific Reports. 10: 21072. PMID 33273561 DOI: 10.1038/s41598-020-78003-z  0.3
2017 Knowles HJ. Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease. Frontiers in Endocrinology. 8: 80. PMID 28458654 DOI: 10.3389/fendo.2017.00080  0.301
2017 Hulley PA, Bishop T, Vernet A, Schneider JE, Edwards JR, Athanasou NA, Knowles HJ. Hypoxia-Inducible Factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. The Journal of Pathology. PMID 28418093 DOI: 10.1002/path.4906  0.362
2017 Knowles HJ. Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone. Calcified Tissue International. 100: 382-391. PMID 28097375 DOI: 10.1007/s00223-016-0228-1  0.327
2012 Taylor RM, Kashima TG, Knowles HJ, Athanasou NA. VEGF, FLT3 ligand, PlGF and HGF can substitute for M-CSF to induce human osteoclast formation: implications for giant cell tumour pathobiology. Laboratory Investigation; a Journal of Technical Methods and Pathology. 92: 1398-406. PMID 22906984 DOI: 10.1038/labinvest.2012.108  0.315
2011 Taylor R, Knowles HJ, Athanasou NA. Ewing sarcoma cells express RANKL and support osteoclastogenesis. The Journal of Pathology. 225: 195-202. PMID 21547906 DOI: 10.1002/path.2869  0.333
2010 Knowles HJ, Cleton-Jansen AM, Korsching E, Athanasou NA. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4648-59. PMID 20667978 DOI: 10.1096/Fj.10-162230  0.377
2010 Knowles HJ, Schaefer KL, Dirksen U, Athanasou NA. Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. Bmc Cancer. 10: 372. PMID 20637078 DOI: 10.1186/1471-2407-10-372  0.441
2010 Benson RT, McDonnell SM, Knowles HJ, Rees JL, Carr AJ, Hulley PA. Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis. The Journal of Bone and Joint Surgery. British Volume. 92: 448-53. PMID 20190320 DOI: 10.1302/0301-620X.92B3.23074  0.374
2010 Knowles H, Cleton-Jansen A, Korsching E, Athanasou N. Hypoxia-Inducible Factor (HIF) regulates Osteoclast-Mediated Bone Resorption via Angiopoietin-like 4 (ANGPTL4) Bone. 46. DOI: 10.1016/J.Bone.2010.01.151  0.331
2009 Knowles HJ, Athanasou NA. Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis. The Journal of Pathology. 218: 256-64. PMID 19291710 DOI: 10.1002/path.2534  0.354
2009 Knowles HJ, Athanasou NA. Canonical and non-canonical pathways of osteoclast formation. Histology and Histopathology. 24: 337-46. PMID 19130404 DOI: 10.14670/HH-24.337  0.304
2008 Knowles HJ, Athanasou NA. Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF. The Journal of Pathology. 215: 56-66. PMID 18283716 DOI: 10.1002/path.2319  0.549
2007 Knowles HJ, Harris AL. Macrophages and the hypoxic tumour microenvironment. Frontiers in Bioscience : a Journal and Virtual Library. 12: 4298-314. PMID 17485376 DOI: 10.2741/2389  0.451
2006 Knowles HJ, Mole DR, Ratcliffe PJ, Harris AL. Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Research. 66: 2600-7. PMID 16510578 DOI: 10.1158/0008-5472.Can-05-2351  0.619
2006 Knowles HJ, te Poele RH, Te Poole R, Workman P, Harris AL. Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochemical Pharmacology. 71: 646-56. PMID 16386710 DOI: 10.1016/j.bcp.2005.11.019  0.492
2004 Knowles HJ, Tian YM, Mole DR, Harris AL. Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circulation Research. 95: 162-9. PMID 15192023 DOI: 10.1161/01.RES.0000134924.89412.70  0.542
2004 Knowles H, Leek R, Harris AL. Macrophage infiltration and angiogenesis in human malignancy. Novartis Foundation Symposium. 256: 189-200; discussion . PMID 15027491  0.574
2003 Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Research. 63: 1764-8. PMID 12702559  0.538
2001 Knowles HJ, Harris AL. Hypoxia and tumorigenesis Breast Cancer Research. 3: 318-322. PMID 11597321 DOI: 10.1186/bcr314  0.526
Low-probability matches (unlikely to be authored by this person)
2013 Morten KJ, Badder L, Knowles HJ. Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts. The Journal of Pathology. 229: 755-64. PMID 23303559 DOI: 10.1002/path.4159  0.289
2018 Zhang T, Kastrenopoulou A, Larrouture Q, Athanasou NA, Knowles HJ. Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis. Bmc Cancer. 18: 536. PMID 29739381 DOI: 10.1186/s12885-018-4468-5  0.281
2011 Hemingway F, Cheng X, Knowles HJ, Estrada FM, Gordon S, Athanasou NA. In vitro generation of mature human osteoclasts. Calcified Tissue International. 89: 389-95. PMID 21960377 DOI: 10.1007/s00223-011-9530-0  0.273
2023 Knowles HJ, Vasilyeva A, Sheth M, Pattinson O, May J, Rumney RMH, Hulley PA, Richards DB, Carugo D, Evans ND, Stride E. Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation. Biomaterials. 305: 122448. PMID 38218121 DOI: 10.1016/j.biomaterials.2023.122448  0.27
2014 Swales C, Athanasou NA, Knowles HJ. Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption. Plos One. 9: e109524. PMID 25289668 DOI: 10.1371/journal.pone.0109524  0.269
2008 Knowles HJ, Athanasou NA. Effects of hypoxia on osteoclast formation and function: A balance between enhanced resorptive activity and increased apoptosis Bone. 42: S38. DOI: 10.1016/J.BONE.2007.12.059  0.246
2011 Taylor R, Kashima TG, Knowles H, Gibbons CLMH, Whitwell D, Athanasou NA. Osteoclast formation and function in pigmented villonodular synovitis Journal of Pathology. 225: 151-156. PMID 21706481 DOI: 10.1002/path.2937  0.241
2015 Knowles HJ. Hypoxic regulation of osteoclast differentiation and bone resorption activity. Hypoxia (Auckland, N.Z.). 3: 73-82. PMID 27774484 DOI: 10.2147/HP.S95960  0.238
2018 Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, et al. BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150413 DOI: 10.1073/pnas.1810498115  0.23
2019 Knowles HJ. The Adenosine A Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments. Cells. 8. PMID 31234425 DOI: 10.3390/cells8060624  0.223
2012 Knowles HJ, Moskovsky L, Thompson MS, Grunhen J, Cheng X, Kashima TG, Athanasou NA. Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption. Virchows Archiv : An International Journal of Pathology. 461: 205-10. PMID 22782381 DOI: 10.1007/s00428-012-1274-3  0.22
2014 Poulsen RC, Knowles HJ, Carr AJ, Hulley PA. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death & Disease. 5: e1074. PMID 24556689 DOI: 10.1038/cddis.2014.52  0.215
2022 Cottone L, Ligammari L, Lee HM, Knowles HJ, Henderson S, Bianco S, Davies C, Strauss S, Amary F, Leite AP, Tirabosco R, Haendler K, Schultze JL, Herrero J, O'Donnell P, et al. Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone. Cell Death and Differentiation. PMID 36138226 DOI: 10.1038/s41418-022-01031-x  0.213
2020 Hulley PA, Papadimitriou-Olivgeri I, Knowles HJ. Osteoblast-Osteoclast Coculture Amplifies Inhibitory Effects of FG-4592 on Human Osteoclastogenesis and Reduces Bone Resorption. Jbmr Plus. 4: e10370. PMID 32666021 DOI: 10.1002/jbm4.10370  0.209
2010 Taylor R, Hemingway F, Knowles H, Athanasou N. Identification of Growth Factors Involved in Non-canonical (MCSF Independent) Pathways of Human Osteoclast Formation Bone. 46. DOI: 10.1016/J.Bone.2010.01.156  0.207
2010 Taylor R, Hemingway F, Knowles H, Athanasou N. Ewing's Sarcoma Cells Promote Osteoclast Formation Bone. 46. DOI: 10.1016/J.Bone.2010.01.157  0.198
2010 Hemingway F, Taylor R, Knowles HJ, Athanasou NA. RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II. Bone. 48: 938-44. PMID 21193069 DOI: 10.1016/j.bone.2010.12.023  0.189
2012 Taylor RM, Kashima TG, Hemingway FK, Dongre A, Knowles HJ, Athanasou NA. CD14- mononuclear stromal cells support (CD14+) monocyte-osteoclast differentiation in aneurysmal bone cyst. Laboratory Investigation; a Journal of Technical Methods and Pathology. 92: 600-5. PMID 22330339 DOI: 10.1038/labinvest.2012.5  0.186
2013 Hemingway F, Kashima TG, Knowles HJ, Athanasou NA. Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT. Experimental and Molecular Pathology. 94: 380-5. PMID 23391709 DOI: 10.1016/j.yexmp.2013.01.003  0.179
2011 Balla P, Moskovszky L, Sapi Z, Forsyth R, Knowles H, Athanasou NA, Szendroi M, Kopper L, Rajnai H, Pinter F, Petak I, Benassi MS, Picci P, Conti A, Krenacs T. Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone. Histopathology. 59: 376-89. PMID 22034878 DOI: 10.1111/J.1365-2559.2011.03948.X  0.178
2023 Knowles HJ, Chanalaris A, Koutsikouni A, Cribbs AP, Grover LM, Hulley PA. Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin. Frontiers in Endocrinology. 14: 1167734. PMID 37223031 DOI: 10.3389/fendo.2023.1167734  0.173
2021 Larrouture QC, Cribbs AP, Rao SR, Philpott M, Snelling SJ, Knowles HJ. Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs. Scientific Reports. 11: 22708. PMID 34811438 DOI: 10.1038/s41598-021-02246-7  0.139
2022 Hulley PA, Knowles HJ. A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups. Cells. 11. PMID 36552735 DOI: 10.3390/cells11243973  0.132
2019 Gooding S, Olechnowicz SWZ, Morris EV, Armitage AE, Arezes J, Frost J, Repapi E, Edwards JR, Ashley N, Waugh C, Gray N, Martinez-Hackert E, Lim PJ, Pasricha SR, Knowles H, et al. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Nature Communications. 10: 4533. PMID 31586071 DOI: 10.1038/s41467-019-12296-1  0.12
2011 Knowles HJ. A dialogue on death penalty dignity Criminology & Criminal Justice. 11: 115-128. DOI: 10.1177/1748895811398457  0.1
2012 Berghuis D, Schilham MW, Santos SJ, Savola S, Knowles HJ, Dirksen U, Schaefer KL, Vakkila J, Hogendoorn PC, Lankester AC. The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease. Clinical Sarcoma Research. 2: 24. PMID 23249693 DOI: 10.1186/2045-3329-2-24  0.099
2013 Messner I, Cadeddu G, Huckenbeck W, Knowles HJ, Gabbert HE, Baldus SE, Schaefer KL. KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines. Journal of Cancer Research and Clinical Oncology. 139: 201-9. PMID 23015072 DOI: 10.1007/s00432-012-1319-7  0.094
2014 Swales C, Athanasou N, Knowles H. AB0093 Angiopoietin-Like 4 is Over–Expressed in Rheumatoid Arthritis: A Potential Role in Pathological Bone Resorption Annals of the Rheumatic Diseases. 73: 834.3-835. DOI: 10.1136/annrheumdis-2014-eular.4208  0.091
2023 Rossi M, Knowles HJ, Del Fattore A. Editorial: Advances in the endocrine role of the skeleton volume II. Frontiers in Endocrinology. 14: 1345813. PMID 38174336 DOI: 10.3389/fendo.2023.1345813  0.075
2014 Swales C, Athanasou NA, Knowles HJ. A4.9 Angiopoietin-like 4 is over–expressed in rheumatoid arthritis: a potential role in pathological bone resorption Annals of the Rheumatic Diseases. 73: A60.1-A60. DOI: 10.1136/annrheumdis-2013-205124.136  0.065
2017 Blackshaw H, Carding P, Jepson M, Mat Baki M, Ambler G, Schilder A, Morris S, Degun A, Yu R, Husbands S, Knowles H, Walton C, Karagama Y, Heathcote K, Birchall M. Does laryngeal reinnervation or type I thyroplasty give better voice results for patients with unilateral vocal fold paralysis (VOCALIST): study protocol for a feasibility randomised controlled trial. Bmj Open. 7: e016871. PMID 28965097 DOI: 10.1136/Bmjopen-2017-016871  0.061
2018 Wright CE, Yeung S, Knowles H, Woodhouse A, Barron E, Evans S. Factors influencing variation in participation in the National Diabetes Audit and the impact on the Quality and Outcomes Framework indicators of diabetes care management. Bmj Open Diabetes Research & Care. 6: e000554. PMID 30397490 DOI: 10.1136/bmjdrc-2018-000554  0.056
2021 Knowles HJ. Peter Augustine Lawler and Richard M. Reinsch II. A Constitution in Full: Recovering the Unwritten Foundation of American Liberty. Lawrence: University Press of Kansas, 2019. Pp. 192. $29.95 (cloth). American Political Thought. 10: 519-522. DOI: 10.1086/715142  0.056
2010 Biliavska IV, Bortkevych OP, Ceeraz S, Spencer J, Choy EH, Corrigall V, Bombardieri M, Kam YNW, Brentano F, Choi K, Kyburz D, McInnes IB, Pitzalis C, Gompels LL, Vincent T, ... ... Knowles H, et al. Concurrent Oral 9 – Rheumatoid Arthritis: Aetiopathogenesis [OP59–OP64] OP59. The Value of Interleukin-17 Serum Level in Rheumatoid Arthritis Immunopathogenesis Rheumatology. 49. DOI: 10.1093/Rheumatology/Keq709  0.05
2014 Knowles HJ. Confessional Crises and Cultural Politics in Twentieth-Century America. By Dave Tell. (University Park, PA: Pennsylvania State University Press, 2012. Pp. ix, 238. $64.95.) The Historian. 76: 836-837. DOI: 10.1111/HISN.12054_28  0.049
1971 Gibbs RJ, MacFarlane DW, Knowles HJ, Kelly FW, Fetherston CR, Bannicke LB. A Review of the National Energy Board Policies and Practices and Recent Hearings Alberta Law Review. 9: 523. DOI: 10.29173/ALR536  0.042
2013 Knowles HJ. Seeing the Light: Lysander Spooner's Increasingly Popular Constitutionalism Law and History Review. 31: 531-558. DOI: 10.1017/S0738248013000242  0.032
2012 Knowles HJ. Abraham Lincoln and Treason in the Civil War: The Trials of John Merryman Civil War Book Review. 14. DOI: 10.31390/CWBR.14.1.06  0.021
2012 Knowles HJ. Cruel and Unusual: The American Death Penalty and the Founders' Eighth Amendment Journal of American History. 99: 881-881. DOI: 10.1093/JAHIST/JAS434  0.018
2014 Uppal E, Davies S, Knowles H, Kandell S. The art of midwifery: can creative images of birth enhance holistic care? Nurse Education in Practice. 14: 311-8. PMID 24637004 DOI: 10.1016/j.nepr.2014.01.013  0.013
2017 Knowles HJ. Speaking Freely: Whitney v. California and American Speech Law. By Philippa Strum. Lawrence: University Press of Kansas, 2015. 186p. $45.00 cloth, 18.95 paper. Perspectives On Politics. 15: 255-257. DOI: 10.1017/S1537592716004928  0.01
2012 Knowles HJ. “Omak's Minimum Pay Law Joan D'Arc”: Telling the Local Story ofWest Coast Hotelv.Parrish(1937) Journal of Supreme Court History. 37: 283-304. DOI: 10.1111/j.1540-5818.2012.01297.x  0.01
2007 Knowles HJ. The Constitution and Slavery: A Special Relationship Slavery & Abolition. 28: 309-328. DOI: 10.1080/01440390701685514  0.01
2006 KNOWLES HJ. May It Please the Court? The Solicitor General's Not-So-"Special" Relationship: Archibald Cox and the 1963?1964 Reapportionment Cases Journal of Supreme Court History. 31: 279-297. DOI: 10.1111/J.1540-5818.2006.00143.X  0.01
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