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Omer Dushek, PhD - Publications

Affiliations: 
2004-2009 Mathematics University of British Columbia, Vancouver, Vancouver, BC, Canada 
 2009- Sir William Dunn School of Pathology University of Oxford, United Kingdom 
Area:
immunology
Website:
https://www.path.ox.ac.uk/content/omer-dushek
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Morgan J, Pettmann J, Dushek O, Lindsay AE. T cell microvilli simulations show operation near packing limit and impact on antigen recognition. Biophysical Journal. PMID 36181267 DOI: 10.1016/j.bpj.2022.09.030  0.428
2022 Céspedes PF, Jainarayanan A, Fernández-Messina L, Valvo S, Saliba DG, Kurz E, Kvalvaag A, Chen L, Ganskow C, Colin-York H, Fritzsche M, Peng Y, Dong T, Johnson E, Siller-Farfán JA, ... Dushek O, et al. T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles. Nature Communications. 13: 3460. PMID 35710644 DOI: 10.1038/s41467-022-31160-3  0.343
2022 Goyette J, Depoil D, Yang Z, Isaacson SA, Allard J, van der Merwe PA, Gaus K, Dustin ML, Dushek O. Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35197288 DOI: 10.1073/pnas.2116815119  0.374
2021 Trendel N, Kruger P, Gaglione S, Nguyen J, Pettmann J, Sontag ED, Dushek O. Perfect adaptation of CD8 T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation. Science Signaling. 14: eaay9363. PMID 34855472 DOI: 10.1126/scisignal.aay9363  0.427
2021 Nguyen J, Pettmann J, Kruger P, Dushek O. Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses. Molecular Systems Biology. 17: e10560. PMID 34806839 DOI: 10.15252/msb.202110560  0.353
2021 Lanz AL, Masi G, Porciello N, Cohnen A, Cipria D, Prakaash D, Bálint Š, Raggiaschi R, Galgano D, Cole DK, Lepore M, Dushek O, Dustin ML, Sansom MSP, Kalli AC, et al. Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation. Cell Reports. 36: 109531. PMID 34380025 DOI: 10.1016/j.celrep.2021.109531  0.444
2021 Lanz AL, Masi G, Porciello N, Cohnen A, Cipria D, Prakaash D, Bálint Š, Raggiaschi R, Galgano D, Cole DK, Lepore M, Dushek O, Dustin ML, Sansom MSP, Kalli AC, et al. Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation. Cell Reports. 36: 109375. PMID 34260912 DOI: 10.1016/j.celrep.2021.109375  0.427
2021 Pettmann J, Huhn A, Abu Shah E, Kutuzov MA, Wilson DB, Dustin ML, Davis SJ, van der Merwe PA, Dushek O. The discriminatory power of the T cell receptor. Elife. 10. PMID 34030769 DOI: 10.7554/eLife.67092  0.441
2020 Abu-Shah E, Trendel N, Kruger P, Nguyen J, Pettmann J, Kutuzov M, Dushek O. Human CD8 T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses. Journal of Immunology (Baltimore, Md. : 1950). PMID 32817332 DOI: 10.4049/jimmunol.2000525  0.307
2019 Abu Shah E, Demetriou P, Bálint Š, Mayya V, Kutuzov MA, Dushek O, Dustin ML. A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells. Elife. 8. PMID 31552826 DOI: 10.7554/Elife.48221  0.373
2019 Fernandes RA, Ganzinger KA, Tzou JC, Jönsson P, Lee SF, Palayret M, Santos AM, Carr AR, Ponjavic A, Chang VT, Macleod C, Lagerholm BC, Lindsay AE, Dushek O, Tilevik A, et al. A cell topography-based mechanism for ligand discrimination by the T cell receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31221762 DOI: 10.1073/Pnas.1817255116  0.524
2018 Pettmann J, Santos AM, Dushek O, Davis SJ. Membrane Ultrastructure and T Cell Activation. Frontiers in Immunology. 9: 2152. PMID 30319617 DOI: 10.3389/Fimmu.2018.02152  0.488
2017 Harris DT, Hager MV, Smith SN, Cai Q, Stone JD, Kruger P, Lever M, Dushek O, Schmitt TM, Greenberg PD, Kranz DM. Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains. Journal of Immunology (Baltimore, Md. : 1950). PMID 29288199 DOI: 10.4049/Jimmunol.1700236  0.398
2017 Goyette J, Salas CS, Coker-Gordon N, Bridge M, Isaacson SA, Allard J, Dushek O. Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1. Science Advances. 3: e1601692. PMID 28378014 DOI: 10.1126/Sciadv.1601692  0.333
2016 Zhang H, Lim HS, Knapp B, Deane CM, Aleksic M, Dushek O, van der Merwe PA. The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding. Scientific Reports. 6: 35326. PMID 27734930 DOI: 10.1038/srep35326  0.442
2016 Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O. Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose. Proceedings of the National Academy of Sciences of the United States of America. PMID 27702900 DOI: 10.1073/pnas.1608820113  0.4
2016 Mukhopadhyay H, de Wet B, Clemens L, Maini PK, Allard J, van der Merwe PA, Dushek O. Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response. Biophysical Journal. 110: 1896-906. PMID 27119648 DOI: 10.1016/j.bpj.2016.03.024  0.33
2016 Jönsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, ... ... Dushek O, et al. Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114505 DOI: 10.1073/Pnas.1513918113  0.308
2015 Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, et al. A THEMIS:SHP1 complex promotes T-cell survival. The Embo Journal. 34: 393-409. PMID 25535246 DOI: 10.15252/Embj.201387725  0.349
2014 Lever M, Maini PK, van der Merwe PA, Dushek O. Phenotypic models of T cell activation. Nature Reviews. Immunology. 14: 619-29. PMID 25145757 DOI: 10.1038/nri3728  0.49
2013 Mukhopadhyay H, Cordoba SP, Maini PK, van der Merwe PA, Dushek O. Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity. Plos Computational Biology. 9: e1003004. PMID 23555234 DOI: 10.1371/journal.pcbi.1003004  0.34
2012 Allard JF, Dushek O, Coombs D, van der Merwe PA. Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. Biophysical Journal. 102: 1265-73. PMID 22455909 DOI: 10.1016/J.Bpj.2012.02.006  0.607
2012 Robert P, Aleksic M, Dushek O, Cerundolo V, Bongrand P, Van Der Merwe PA. Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands Biophysical Journal. 102: 248-257. PMID 22339861 DOI: 10.1016/J.Bpj.2011.11.4018  0.491
2011 Zhang H, Cordoba SP, Dushek O, van der Merwe PA. Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 19323-8. PMID 22084078 DOI: 10.1073/pnas.1108052108  0.32
2011 Dushek O, Aleksic M, Wheeler RJ, Zhang H, Cordoba SP, Peng YC, Chen JL, Cerundolo V, Dong T, Coombs D, van der Merwe PA. Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation. Science Signaling. 4: ra39. PMID 21653229 DOI: 10.1126/Scisignal.2001430  0.657
2010 Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V, Dushek O, Höfer T, Viola A, Acuto O. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity. 32: 766-77. PMID 20541955 DOI: 10.1016/J.Immuni.2010.05.011  0.427
2010 Aleksic M, Dushek O, Zhang H, Shenderov E, Chen JL, Cerundolo V, Coombs D, van der Merwe PA. Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time. Immunity. 32: 163-74. PMID 20137987 DOI: 10.1016/J.Immuni.2009.11.013  0.654
2009 Dushek O, Das R, Coombs D. A role for rebinding in rapid and reliable T cell responses to antigen. Plos Computational Biology. 5: e1000578. PMID 19956745 DOI: 10.1371/Journal.Pcbi.1000578  0.668
2008 Dushek O, Mueller S, Soubies S, Depoil D, Caramalho I, Coombs D, Valitutti S. Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery. Plos One. 3: e3913. PMID 19079546 DOI: 10.1371/Journal.Pone.0003913  0.636
2008 Dushek O, Das R, Coombs D. Analysis of membrane-localized binding kinetics with FRAP. European Biophysics Journal : Ebj. 37: 627-38. PMID 18299825 DOI: 10.1007/S00249-008-0286-Z  0.561
2008 Dushek O, Coombs D. Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters. Biophysical Journal. 94: 3447-60. PMID 18227132 DOI: 10.1529/Biophysj.107.116897  0.636
2008 Dushek O, Coombs D. Improving parameter estimation for cell surface FRAP data. Journal of Biochemical and Biophysical Methods. 70: 1224-31. PMID 17707082 DOI: 10.1016/J.Jbbm.2007.07.002  0.56
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