| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2013 | Chen JJ, Qian W, Biswas K, Yuan C, Amegadzie A, Liu Q, Nixey T, Zhu J, Ncube M, Rzasa RM, Chavez F, Chen N, DeMorin F, Rumfelt S, Tegley CM, et al. Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 23: 6447-54. PMID 24139583 DOI: 10.1016/j.bmcl.2013.09.041 | 0.589 | |||
| 2011 | Li A, Yuan CC, Chow D, Chen M, Emery MG, Hale C, Zhang X, Subramanian R, St Jean DJ, Komorowski R, Véniant M, Wang M, Fotsch C. Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes. Acs Medicinal Chemistry Letters. 2: 824-7. PMID 24900270 DOI: 10.1021/ml2001467 | 0.478 | |||
| 2010 | Zeng Q, Allen JG, Bourbeau MP, Wang X, Yao G, Tadesse S, Rider JT, Yuan CC, Hong FT, Lee MR, Zhang S, Lofgren JA, Freeman DJ, Yang S, Li C, et al. Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 20: 1559-64. PMID 20137943 DOI: 10.1016/J.Bmcl.2010.01.067 | 0.379 | |||
| 2010 | Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, et al. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening. Chemical Research in Toxicology. 23: 653-63. PMID 20095585 DOI: 10.1021/Tx900414G | 0.325 | |||
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