| Year |
Citation |
Score |
| 2023 |
Temponeras I, Samiotaki M, Koumantou D, Nikopaschou M, Kuiper JJW, Panayotou G, Stratikos E. Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1. European Journal of Immunology. 53: e2350449. PMID 37134263 DOI: 10.1002/eji.202350449 |
0.51 |
|
| 2023 |
Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ. Author Correction: Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nature Communications. 14: 1536. PMID 36941276 DOI: 10.1038/s41467-023-37300-7 |
0.517 |
|
| 2022 |
Georgiadis D, Skoulikas N, Papakyriakou A, Stratikos E. Phosphinic Peptides as Tool Compounds for the Study of Pharmacologically Relevant Zn-Metalloproteases. Acs Pharmacology & Translational Science. 5: 1228-1253. PMID 36524013 DOI: 10.1021/acsptsci.2c00183 |
0.393 |
|
| 2022 |
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Piveteau C, ... ... Stratikos E, et al. Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis. Angewandte Chemie (International Ed. in English). e202203560. PMID 35904863 DOI: 10.1002/anie.202203560 |
0.303 |
|
| 2022 |
Papakyriakou A, Mpakali A, Stratikos E. Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation. Frontiers in Immunology. 13: 863529. PMID 35514997 DOI: 10.3389/fimmu.2022.863529 |
0.375 |
|
| 2022 |
Mpakali A, Georgiadis D, Stratikos E, Giastas P. Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Medicinal Chemistry Letters. 13: 218-224. PMID 35178178 DOI: 10.1021/acsmedchemlett.1c00582 |
0.393 |
|
| 2022 |
Temponeras I, Stamatakis G, Samiotaki M, Georgiadis D, Pratsinis H, Panayotou G, Stratikos E. ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides. International Journal of Molecular Sciences. 23. PMID 35163832 DOI: 10.3390/ijms23031913 |
0.396 |
|
| 2021 |
Stamatakis G, Samiotaki M, Temponeras I, Panayotou G, Stratikos E. Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein. The Journal of Biological Chemistry. 297: 101329. PMID 34688668 DOI: 10.1016/j.jbc.2021.101329 |
0.349 |
|
| 2021 |
Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ. Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nature Communications. 12: 5302. PMID 34489420 DOI: 10.1038/s41467-021-25564-w |
0.63 |
|
| 2021 |
Mavridis G, Mpakali A, Zoidakis J, Makridakis M, Vlahou A, Kaloumenou E, Ziotopoulou A, Georgiadis D, Papakyriakou A, Stratikos E. The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I. Scientific Reports. 11: 16475. PMID 34389743 DOI: 10.1038/s41598-021-95786-x |
0.423 |
|
| 2021 |
Venema WJ, Hiddingh S, de Boer JH, Claas FHJ, Mulder A, den Hollander AI, Stratikos E, Sarkizova S, van der Veken LT, Janssen GMC, van Veelen PA, Kuiper JJW. ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29. Frontiers in Immunology. 12: 634441. PMID 33717175 DOI: 10.3389/fimmu.2021.634441 |
0.34 |
|
| 2021 |
Hutchinson JP, Temponeras I, Kuiper J, Cortes A, Korczynska J, Kitchen S, Stratikos E. Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties. The Journal of Biological Chemistry. 100443. PMID 33617882 DOI: 10.1016/j.jbc.2021.100443 |
0.323 |
|
| 2020 |
Stamatakis G, Samiotaki M, Mpakali A, Panayotou G, Stratikos E. Generation of SARS-CoV-2 S1 Spike Glycoprotein Putative Antigenic Epitopes in Vitro by Intracellular Aminopeptidases. Journal of Proteome Research. 19: 4398-4406. PMID 32931291 DOI: 10.1021/acs.jproteome.0c00457 |
0.441 |
|
| 2020 |
Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, Stratikos E. Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor. Acs Medicinal Chemistry Letters. 11: 1429-1434. PMID 32676150 DOI: 10.1021/Acsmedchemlett.0C00172 |
0.628 |
|
| 2020 |
Mavridis G, Arya R, Domnick A, Zoidakis J, Makridakis M, Vlahou A, Mpakali A, Lelis A, Georgiadis D, Tampé R, Papakyriakou A, Stern LJ, Stratikos E. A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1. The Journal of Biological Chemistry. PMID 32184355 DOI: 10.1074/Jbc.Ra120.012976 |
0.654 |
|
| 2020 |
Liddle J, Hutchinson JP, Kitchen S, Rowland P, Neu M, Cecconie T, Holmes DS, Jones EJ, Korczynska J, Koumantou D, Lea J, Nickels LA, Pemberton M, Phillipou A, Schneck JL, ... ... Stratikos E, et al. Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation. Journal of Medicinal Chemistry. PMID 32109056 DOI: 10.1021/acs.jmedchem.9b02123 |
0.363 |
|
| 2019 |
Giastas P, Mpakali A, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D, Stratikos E. Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1. Proceedings of the National Academy of Sciences of the United States of America. PMID 31843903 DOI: 10.1073/pnas.1912070116 |
0.506 |
|
| 2019 |
Maben Z, Arya R, Rane D, An WF, Metkar S, Hickey M, Bender S, Ali A, Nguyen TT, Evnouchidou I, Schilling RJ, Stratikos E, Golden JE, Stern LJ. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. Journal of Medicinal Chemistry. PMID 31841350 DOI: 10.1021/Acs.Jmedchem.9B00293 |
0.556 |
|
| 2019 |
Tsoukalidou S, Kakou M, Mavridis I, Koumantou D, Calderone V, Fragai M, Stratikos E, Papakyriakou A, Vourloumis D. Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases. Bioorganic & Medicinal Chemistry. 115177. PMID 31711716 DOI: 10.1016/j.bmc.2019.115177 |
0.365 |
|
| 2019 |
Koumantou D, Barnea E, Martin-Esteban A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A, Stratikos E. Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1). Cancer Immunology, Immunotherapy : Cii. PMID 31222486 DOI: 10.1007/S00262-019-02358-0 |
0.634 |
|
| 2019 |
Giastas P, Neu M, Rowland P, Stratikos E. High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor. Acs Medicinal Chemistry Letters. 10: 708-713. PMID 31097987 DOI: 10.1021/acsmedchemlett.9b00002 |
0.381 |
|
| 2019 |
Georgiadis D, Mpakali A, Koumantou D, Stratikos E. Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application. Current Medicinal Chemistry. 26: 2715-2729. PMID 29446724 DOI: 10.2174/0929867325666180214111849 |
0.371 |
|
| 2018 |
de Castro JAL, Stratikos E. Intracellular Antigen Processing by ERAP2: Molecular Mechanism and Roles in Health and Disease. Human Immunology. PMID 30414458 DOI: 10.1016/j.humimm.2018.11.001 |
0.389 |
|
| 2018 |
Mpakali A, Maben Z, Stern LJ, Stratikos E. Molecular pathways for antigenic peptide generation by ER aminopeptidase 1. Molecular Immunology. PMID 29678301 DOI: 10.1016/J.Molimm.2018.03.026 |
0.652 |
|
| 2017 |
Papakyriakou A, Stratikos E. The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases. Frontiers in Immunology. 8: 946. PMID 28824657 DOI: 10.3389/fimmu.2017.00946 |
0.517 |
|
| 2017 |
Mpakali A, Giastas P, Deprez-Poulain R, Papakyriakou A, Koumantou D, Gealageas R, Tsoukalidou S, Vourloumis D, Mavridis IM, Stratikos E, Saridakis E. Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. Acs Medicinal Chemistry Letters. 8: 333-337. PMID 28337326 DOI: 10.1021/acsmedchemlett.6b00505 |
0.386 |
|
| 2017 |
Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E. Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity. Journal of Medicinal Chemistry. PMID 28328206 DOI: 10.1021/acs.jmedchem.6b01890 |
0.418 |
|
| 2017 |
Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E. Critical role of inter-domain interactions on the conformational change and catalytic mechanism of Endoplasmic Reticulum Aminopeptidase 1. Biochemistry. PMID 28218509 DOI: 10.1021/Acs.Biochem.6B01170 |
0.644 |
|
| 2016 |
Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D. Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides. Journal of Medicinal Chemistry. 59: 9107-9123. PMID 27606717 DOI: 10.1021/Acs.Jmedchem.6B01031 |
0.36 |
|
| 2015 |
Mpakali A, Giastas P, Mathioudakis N, Mavridis IM, Saridakis E, Stratikos E. Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2. The Journal of Biological Chemistry. 290: 26021-32. PMID 26381406 DOI: 10.1074/jbc.M115.685909 |
0.504 |
|
| 2015 |
Mpakali A, Saridakis E, Harlos K, Zhao Y, Papakyriakou A, Kokkala P, Georgiadis D, Stratikos E. Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. Journal of Immunology (Baltimore, Md. : 1950). 195: 2842-51. PMID 26259583 DOI: 10.4049/jimmunol.1501103 |
0.534 |
|
| 2015 |
Stamogiannos A, Koumantou D, Papakyriakou A, Stratikos E. Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1. Molecular Immunology. 67: 426-35. PMID 26224046 DOI: 10.1016/j.molimm.2015.07.010 |
0.394 |
|
| 2014 |
Stratikos E. Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides. Current Opinion in Chemical Biology. 23: 1-7. PMID 25173825 DOI: 10.1016/j.cbpa.2014.08.007 |
0.302 |
|
| 2013 |
Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proceedings of the National Academy of Sciences of the United States of America. 110: 19890-5. PMID 24248368 DOI: 10.1073/Pnas.1309781110 |
0.325 |
|
| 2013 |
Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A. Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens. Autoimmunity. 46: 497-508. PMID 24028501 DOI: 10.3109/08916934.2013.819855 |
0.357 |
|
| 2013 |
Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorganic & Medicinal Chemistry Letters. 23: 4832-6. PMID 23916253 DOI: 10.1016/J.Bmcl.2013.07.024 |
0.362 |
|
| 2013 |
Stratikos E, Stern LJ. Antigenic peptide trimming by ER aminopeptidases--insights from structural studies. Molecular Immunology. 55: 212-9. PMID 23545452 DOI: 10.1016/J.Molimm.2013.03.002 |
0.605 |
|
| 2012 |
Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E. A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing. Journal of Immunology (Baltimore, Md. : 1950). 189: 2383-92. PMID 22837489 DOI: 10.4049/Jimmunol.1200918 |
0.325 |
|
| 2012 |
Birtley JR, Saridakis E, Stratikos E, Mavridis IM. The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing. Biochemistry. 51: 286-95. PMID 22106953 DOI: 10.1021/bi201230p |
0.506 |
|
| 2011 |
Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, Goldberg AL, Stratikos E, Stern LJ. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nature Structural & Molecular Biology. 18: 604-13. PMID 21478864 DOI: 10.1038/Nsmb.2021 |
0.654 |
|
| 2011 |
Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. The Biochemical Journal. 435: 411-20. PMID 21314638 DOI: 10.1042/Bj20102049 |
0.498 |
|
| 2011 |
Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E. Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme. Journal of Immunology (Baltimore, Md. : 1950). 186: 1909-13. PMID 21242517 DOI: 10.4049/Jimmunol.1003337 |
0.336 |
|
| 2010 |
Georgiadou D, Hearn A, Evnouchidou I, Chroni A, Leondiadis L, York IA, Rock KL, Stratikos E. Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1. Journal of Immunology (Baltimore, Md. : 1950). 185: 1584-92. PMID 20592285 DOI: 10.4049/Jimmunol.0902502 |
0.466 |
|
| 2010 |
Evnouchidou I, Papakyriakou A, Stratikos E. A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction. Current Pharmaceutical Design. 15: 3656-70. PMID 19925418 DOI: 10.2174/138161209789271816 |
0.426 |
|
| 2009 |
Evnouchidou I, Berardi MJ, Stratikos E. A continuous fluorigenic assay for the measurement of the activity of endoplasmic reticulum aminopeptidase 1: competition kinetics as a tool for enzyme specificity investigation. Analytical Biochemistry. 395: 33-40. PMID 19638272 DOI: 10.1016/j.ab.2009.07.032 |
0.443 |
|
| 2008 |
Evnouchidou I, Momburg F, Papakyriakou A, Chroni A, Leondiadis L, Chang SC, Goldberg AL, Stratikos E. The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. Plos One. 3: e3658. PMID 18987748 DOI: 10.1371/journal.pone.0003658 |
0.477 |
|
| 2004 |
Stratikos E, Wiley DC, Stern LJ. Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain. Journal of Immunology (Baltimore, Md. : 1950). 172: 1109-17. PMID 14707085 DOI: 10.4049/Jimmunol.172.2.1109 |
0.661 |
|
| 2002 |
Stratikos E, Mosyak L, Zaller DM, Wiley DC. Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis. The Journal of Experimental Medicine. 196: 173-83. PMID 12119342 DOI: 10.1084/Jem.20020117 |
0.625 |
|
| 2002 |
Backovic M, Stratikos E, Lawrence DA, Gettins PG. Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment. Protein Science : a Publication of the Protein Society. 11: 1182-91. PMID 11967374 DOI: 10.1110/Ps.4320102 |
0.62 |
|
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