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Pedro Manuel Garcia-Barrantes, M.D. - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
 University of Costa Rica 
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ. Activation of the mGlu metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M muscarinic receptor allosteric modulators. Molecular Psychiatry. PMID 30116027 DOI: 10.1038/S41380-018-0206-2  0.571
2018 Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW. The discovery of VU0486846: steep SAR from a series of M PAMs based on a novel benzomorpholine core. Bioorganic & Medicinal Chemistry Letters. PMID 29754948 DOI: 10.1016/J.Bmcl.2018.05.009  0.666
2018 Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp J, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, et al. A novel M1 PAM VU0486846 exerts efficacy in cognition models without displaying agonist activity or cholinergic toxicity. Acs Chemical Neuroscience. PMID 29701957 DOI: 10.1021/Acschemneuro.8B00131  0.658
2017 Garcia-Barrantes PM, McGowan K, Ingram SW, Lindsley CW. One pot synthesis of unsymmetrical ketones from carboxylic and boronic acids via PyClU-mediated acylative Suzuki coupling Tetrahedron Letters. 58: 898-901. DOI: 10.1016/J.Tetlet.2017.01.064  0.391
2016 Rook JM, Abe M, Cho HP, Nance KD, Luscombe VB, Adams JJ, Dickerson JW, Remke DH, Garcia-Barrantes PM, Engers DW, Engers JL, Chang S, Foster JJ, Blobaum AL, Niswender CM, et al. Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs. Acs Chemical Neuroscience. PMID 28001356 DOI: 10.1021/Acschemneuro.6B00429  0.78
2016 Garcia-Barrantes PM, Lindsley CW. Total Synthesis of Gombamide A. Organic Letters. PMID 27442228 DOI: 10.1021/Acs.Orglett.6B01825  0.437
2016 Panarese JD, Cho HP, Adams JJ, Nance KD, Garcia-Barrantes PM, Chang S, Morrison RD, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorganic & Medicinal Chemistry Letters. PMID 27173801 DOI: 10.1016/J.Bmcl.2016.04.083  0.762
2016 Gogliotti RD, Engers DW, Garcia-Barrantes PM, Panarese JD, Gentry PR, Blobaum AL, Morrison RD, Daniels JS, Thompson AD, Jones CK, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. Bioorganic & Medicinal Chemistry Letters. PMID 27131990 DOI: 10.1016/J.Bmcl.2016.04.041  0.539
2016 Engers DW, Blobaum AL, Gogliotti RD, Cheung YY, Salovich JM, Garcia-Barrantes PM, Daniels JS, Morrison R, Jones CK, Soars MG, Zhuo X, Hurley J, Macor JE, Bronson JJ, Conn PJ, et al. Discovery, Synthesis and Pre-Clinical Characterization of N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4). Acs Chemical Neuroscience. PMID 27075300 DOI: 10.1021/Acschemneuro.6B00035  0.523
2016 Garcia-Barrantes PM, Cho HP, Starr TM, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW. Re-exploration of the mGlu1 PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR. Bioorganic & Medicinal Chemistry Letters. PMID 27013388 DOI: 10.1016/J.Bmcl.2016.03.044  0.586
2016 Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs. Bioorganic & Medicinal Chemistry Letters. PMID 26988302 DOI: 10.1016/J.Bmcl.2016.03.031  0.506
2016 Garcia-Barrantes PM, Cho HP, Metts AM, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool. Bioorganic & Medicinal Chemistry Letters. PMID 26778256 DOI: 10.1016/J.Bmcl.2015.12.104  0.577
2016 Garcia-Barrantes PM, Harp JR, Lindsley CW. Total synthesis of actinophenanthroline A Tetrahedron Letters. 57: 2194-2196. DOI: 10.1016/J.Tetlet.2016.04.019  0.424
2015 Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core. Bioorganic & Medicinal Chemistry Letters. 25: 5107-10. PMID 26476971 DOI: 10.1016/J.Bmcl.2015.10.013  0.57
2015 Garcia-Barrantes PM, Cho HP, Niswender CM, Byers FW, Locuson CW, Blobaum AL, Xiang Z, Rook JM, Conn PJ, Lindsley CW. Development of novel, CNS penetrant positive allosteric modulators for the metabotropic glutamate receptor subtype 1 (mGlu1), based on an N-(3-chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide scaffold, that potentiate both wild type and mutant mGlu1 receptors found in schizophrenics. Journal of Medicinal Chemistry. PMID 26426481 DOI: 10.1021/Acs.Jmedchem.5B00727  0.577
2015 Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Garcia-Barrantes PM, Lavreysen H, Mackie C, Vinson PN, Rook JM, Bridges TM, Daniels JS, Megens A, Langlois X, Drinkenburg WH, Ahnaou A, Niswender CM, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. Acs Medicinal Chemistry Letters. 6: 716-20. PMID 26157544 DOI: 10.1021/Acsmedchemlett.5B00181  0.554
2015 Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Garcia-Barrantes PM, Lavreysen H, Mackie C, Vinson PN, Rook JM, Bridges TM, Daniels JS, Megens A, Langlois X, Drinkenburg WH, Ahnaou A, Niswender CM, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia Acs Medicinal Chemistry Letters. 6: 716-720. DOI: 10.1021/acsmedchemlett.5b00181  0.404
2014 Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. Acs Chemical Biology. 9: 2334-46. PMID 25137254 DOI: 10.1021/Cb500560H  0.529
2013 Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. Journal of Medicinal Chemistry. 56: 15-30. PMID 23244564 DOI: 10.1021/Jm301448P  0.708
2013 Lee T, Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Olejniczak ET, Fesik SW. Abstract 2350: Discovery of potent and selective Mcl-1 inhibitors using fragment-based methods and structure-based design. Cancer Research. 73: 2350-2350. DOI: 10.1158/1538-7445.Am2013-2350  0.439
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