| Year |
Citation |
Score |
| 2024 |
Belle R, Saraç H, Salah E, Bhushan B, Szykowska A, Roper G, Tumber A, Kriaucionis S, Burgess-Brown N, Schofield CJ, Brown T, Kawamura A. Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of Medicinal Chemistry. PMID 38294854 DOI: 10.1021/acs.jmedchem.3c01820 |
0.528 |
|
| 2024 |
Šimelis K, Saraç H, Salah E, Nishio K, McAllister TE, Corner TP, Tumber A, Belle R, Schofield CJ, Suga H, Kawamura A. Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling. Bioorganic & Medicinal Chemistry. 99: 117597. PMID 38262305 DOI: 10.1016/j.bmc.2024.117597 |
0.53 |
|
| 2023 |
Corner TP, Teo RZR, Wu Y, Salah E, Nakashima Y, Fiorini G, Tumber A, Brasnett A, Holt-Martyn JP, Figg WD, Zhang X, Brewitz L, Schofield CJ. Structure-guided optimisation of -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chemical Science. 14: 12098-12120. PMID 37969593 DOI: 10.1039/d3sc04253g |
0.317 |
|
| 2023 |
Brewitz L, Nakashima Y, Piasecka SK, Salah E, Fletcher SC, Tumber A, Corner TP, Kennedy TJ, Fiorini G, Thalhammer A, Christensen KE, Coleman ML, Schofield CJ. 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. Journal of Medicinal Chemistry. PMID 37527664 DOI: 10.1021/acs.jmedchem.3c01114 |
0.32 |
|
| 2023 |
Figg WD, Fiorini G, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ. Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2. Proteins. PMID 37449559 DOI: 10.1002/prot.26541 |
0.665 |
|
| 2023 |
Tumber A, Salah E, Brewitz L, Corner TP, Schofield CJ. Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5. Rsc Chemical Biology. 4: 399-413. PMID 37292060 DOI: 10.1039/d2cb00249c |
0.309 |
|
| 2023 |
Miura T, Malla TR, Owen CD, Tumber A, Brewitz L, McDonough MA, Salah E, Terasaka N, Katoh T, Lukacik P, Strain-Damerell C, Mikolajek H, Walsh MA, Kawamura A, Schofield CJ, et al. In vitro selection of macrocyclic peptide inhibitors containing cyclic γ-amino acids targeting the SARS-CoV-2 main protease. Nature Chemistry. PMID 37217786 DOI: 10.1038/s41557-023-01205-1 |
0.641 |
|
| 2023 |
Türkmen VA, Hintzen JCJ, Tumber A, Moesgaard L, Salah E, Kongsted J, Schofield CJ, Mecinović J. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66. Rsc Chemical Biology. 4: 235-243. PMID 36908702 DOI: 10.1039/d2cb00182a |
0.645 |
|
| 2023 |
Bonnici J, Oueini R, Salah E, Johansson C, Schofield CJ, Kawamura A. The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation. Febs Letters. PMID 36700827 DOI: 10.1002/1873-3468.14586 |
0.503 |
|
| 2022 |
Belle R, Kamps JJAG, Poater J, Kumar K, Pieters BJGE, Salah E, Claridge TDW, Paton RS, Bickelhaupt FM, Kawamura A, Schofield CJ, Mecinović J. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. Communications Chemistry. 5: 27. PMID 36697896 DOI: 10.1038/s42004-022-00640-4 |
0.711 |
|
| 2022 |
Islam MS, Markoulides M, Chowdhury R, Schofield CJ. Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Scientific Reports. 12: 20680. PMID 36450832 DOI: 10.1038/s41598-022-24154-0 |
0.821 |
|
| 2022 |
Saward B, Leissing T, Clifton I, Tumber A, Timperley C, Hopkinson R, Schofield C. Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains. Chembiochem : a European Journal of Chemical Biology. PMID 36448355 DOI: 10.1002/cbic.202200576 |
0.569 |
|
| 2022 |
Li Z, Wu Y, Zhen S, Su K, Zhang L, Yang F, McDonough M, Schofield C, Zhang X. In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery. Angewandte Chemie (International Ed. in English). PMID 36112310 DOI: 10.1002/anie.202211510 |
0.487 |
|
| 2022 |
Belle R, Kamps JJAG, Poater J, Kumar K, Pieters BJGE, Salah E, Claridge TDW, Paton RS, Matthias Bickelhaupt F, Kawamura A, Schofield CJ, Mecinović J. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. Communications Chemistry. 5. PMID 36071790 DOI: 10.1038/s42004-022-00640-4 |
0.713 |
|
| 2022 |
Reinbold R, Hvinden IC, Rabe P, Herold RA, Finch A, Wood J, Morgan M, Staudt M, Clifton IJ, Armstrong FA, McCullagh JSO, Redmond J, Bardella C, Abboud MI, Schofield CJ. Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors. Nature Communications. 13: 4785. PMID 35970853 DOI: 10.1038/s41467-022-32436-4 |
0.559 |
|
| 2022 |
Rabe P, Walla CC, Goodyear NK, Welsh J, Southwart R, Clifton I, Linyard JDS, Tumber A, Claridge TDW, Myers WK, Schofield CJ. Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase. The Journal of Biological Chemistry. 102249. PMID 35835215 DOI: 10.1016/j.jbc.2022.102249 |
0.569 |
|
| 2022 |
Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Fang P, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, ... Schofield CJ, et al. Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins. The Journal of Biological Chemistry. 102020. PMID 35537551 DOI: 10.1016/j.jbc.2022.102020 |
0.672 |
|
| 2022 |
Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem J, Schofield CJ. Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117310119. PMID 35486701 DOI: 10.1073/pnas.2117310119 |
0.665 |
|
| 2022 |
Chowdhury R, Abboud MI, Wiley J, Tumber A, Markolovic S, Schofield CJ. Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Scientific Reports. 12: 6065. PMID 35410347 DOI: 10.1038/s41598-022-10028-y |
0.552 |
|
| 2022 |
Kaur S, Tam NY, McDonough MA, Schofield CJ, Aik WS. Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Research. 50: 4148-4160. PMID 35333330 DOI: 10.1093/nar/gkac195 |
0.512 |
|
| 2022 |
Lucic A, Malla TR, Calvopiña K, Tooke CL, Brem J, McDonough MA, Spencer J, Schofield CJ. Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2. Antibiotics (Basel, Switzerland). 11. PMID 35326858 DOI: 10.3390/antibiotics11030396 |
0.499 |
|
| 2021 |
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, ... ... Schofield CJ, et al. Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Nature Chemistry. PMID 34903857 DOI: 10.1038/s41557-021-00831-x |
0.799 |
|
| 2021 |
Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, ... ... Schofield CJ, et al. First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. Journal of Medicinal Chemistry. 64: 17031-17050. PMID 34843649 DOI: 10.1021/acs.jmedchem.1c00605 |
0.535 |
|
| 2021 |
Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, ... Schofield CJ, et al. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. Journal of Medicinal Chemistry. PMID 34762429 DOI: 10.1021/acs.jmedchem.1c01204 |
0.558 |
|
| 2021 |
Islam MS, Thinnes C, Holt-Martyn J, Chowdhury R, McDonough M, Schofield C. Inhibition of JMJD6 by 2-Oxoglutarate Mimics. Chemmedchem. PMID 34581506 DOI: 10.1002/cmdc.202100398 |
0.639 |
|
| 2021 |
Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, ... ... Schofield CJ, et al. X-ray free-electron laser studies reveal correlated motion during isopenicillin synthase catalysis. Science Advances. 7. PMID 34417180 DOI: 10.1126/sciadv.abh0250 |
0.665 |
|
| 2021 |
Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, von Delft F, Brem J, Chibale K, Schofield CJ, Dowson CG. High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes. Journal of Medicinal Chemistry. PMID 34337941 DOI: 10.1021/acs.jmedchem.1c00717 |
0.773 |
|
| 2021 |
Wu Y, Li Z, McDonough MA, Schofield CJ, Zhang X. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy. Journal of Medicinal Chemistry. PMID 34029087 DOI: 10.1021/acs.jmedchem.1c00415 |
0.541 |
|
| 2021 |
Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield C. Human oxygenase variants employing a single protein Fe(II) ligand are catalytically active. Angewandte Chemie (International Ed. in English). PMID 33887099 DOI: 10.1002/anie.202103711 |
0.656 |
|
| 2021 |
Paschalis A, Welti J, Neeb AJ, Yuan W, Figueiredo I, Pereira R, Ferreira A, Riisnaes R, Rodrigues DN, Jiménez-Vacas JM, Kim S, Uo T, Micco PD, Tumber A, Islam MS, ... ... Schofield CJ, et al. JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer. Cancer Research. 81: 1087-1100. PMID 33822745 DOI: 10.1158/0008-5472.CAN-20-1807 |
0.404 |
|
| 2021 |
Figg WD, McDonough MA, Chowdhury R, Nakashima YA, Zhang ZA, Holt-Martyn JP, Krajnc A, Schofield C. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem. PMID 33792169 DOI: 10.1002/cmdc.202100133 |
0.686 |
|
| 2021 |
Lucic A, Hinchliffe P, Malla TR, Tooke CL, Brem J, Calvopiña K, Lohans CT, Rabe P, McDonough MA, Armistead T, Orville AM, Spencer J, Schofield CJ. Faropenem reacts with serine and metallo-β-lactamases to give multiple products. European Journal of Medicinal Chemistry. 215: 113257. PMID 33618159 DOI: 10.1016/j.ejmech.2021.113257 |
0.73 |
|
| 2021 |
Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, ... ... Schofield CJ, et al. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature Communications. 12: 891. PMID 33563959 DOI: 10.1038/s41467-020-20670-7 |
0.508 |
|
| 2020 |
Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, ... Schofield CJ, et al. A human protein hydroxylase that accepts D-residues. Communications Chemistry. 3: 52. PMID 36703414 DOI: 10.1038/s42004-020-0290-5 |
0.788 |
|
| 2020 |
Brewitz L, Nakashima Y, Schofield CJ. Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase. Chemical Science. 12: 1327-1342. PMID 34163896 DOI: 10.1039/d0sc04301j |
0.325 |
|
| 2020 |
Brewitz L, Tumber A, Pfeffer I, McDonough MA, Schofield CJ. Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors. Scientific Reports. 10: 22398. PMID 33349651 DOI: 10.1038/s41598-020-80008-7 |
0.483 |
|
| 2020 |
Chowdhury R, Abboud MI, McAllister TE, Banerji B, Bhushan B, Sorensen JL, Kawamura A, Schofield CJ. Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Scientific Reports. 10: 21964. PMID 33319810 DOI: 10.1038/s41598-020-76307-8 |
0.792 |
|
| 2020 |
Li Z, Zhen S, Su K, Tumber A, Yu Q, Dong Y, McDonough M, Schofield CJ, Zhang X. A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation. Chemical Communications (Cambridge, England). PMID 33111730 DOI: 10.1039/d0cc06353c |
0.513 |
|
| 2020 |
Reinbold R, John T, Spingardi P, Kawamura A, Schofield CJ, Hopkinson RJ. Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde. Scientific Reports. 10: 17955. PMID 33087772 DOI: 10.1038/s41598-020-74990-1 |
0.458 |
|
| 2020 |
Brewitz L, Tumber A, Zhang X, Schofield CJ. Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase Bioorganic & Medicinal Chemistry. 28: 115675. PMID 33069066 DOI: 10.1016/J.Bmc.2020.115675 |
0.37 |
|
| 2020 |
Aertker KMJ, Chan HTH, Lohans CT, Schofield CJ. Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism. The Journal of Biological Chemistry. PMID 32963107 DOI: 10.1074/jbc.RA120.014607 |
0.66 |
|
| 2020 |
Rabe P, Beale JH, Butryn A, Aller P, Dirr A, Lang PA, Axford DN, Carr SB, Leissing TM, McDonough MA, Davy B, Ebrahim A, Orlans J, Storm SLS, Orville AM, ... Schofield CJ, et al. Anaerobic fixed-target serial crystallography. Iucrj. 7: 901-912. PMID 32939282 DOI: 10.1107/S2052252520010374 |
0.533 |
|
| 2020 |
Liu T, Abboud MI, Chowdhury R, Tumber A, Hardy AP, Lippl K, Lohans CT, Pires E, Wickens J, McDonough MA, West CM, Schofield CJ. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry. PMID 32934009 DOI: 10.1074/Jbc.Ra120.013998 |
0.812 |
|
| 2020 |
Robinson CV, El-Baba TJ, Lutomski CA, Kantsadi AL, Malla TR, John T, Mikhailov V, Bolla JR, Schofield CJ, Zitzmann N, Vakonakis I. Allosteric inhibition of the SARS-CoV-2 main protease - insights from mass spectrometry-based assays. Angewandte Chemie (International Ed. in English). PMID 32841477 DOI: 10.1002/Anie.202010316 |
0.338 |
|
| 2020 |
Hsu KF, Wilkins SE, Hopkinson RJ, Sekirnik R, Flashman E, Kawamura A, McCullagh JSO, Walport LJ, Schofield CJ. Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications. Epigenetics. 1-14. PMID 32609604 DOI: 10.1080/15592294.2020.1786305 |
0.537 |
|
| 2020 |
Waheed SO, Ramanan R, Chaturvedi SS, Lehnert N, Schofield CJ, Christov CZ, Karabencheva-Christova TG. Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair. Acs Central Science. 6: 795-814. PMID 32490196 DOI: 10.1021/Acscentsci.0C00312 |
0.32 |
|
| 2020 |
Khan A, Schofield C, Claridge T. Reducing agent mediated non-enzymatic conversion of 2-oxoglutarate to succinate - implications for oxygenase assays. Chembiochem : a European Journal of Chemical Biology. PMID 32478965 DOI: 10.1002/Cbic.202000185 |
0.311 |
|
| 2020 |
Brewitz L, Tumber A, Pfeffer I, McDonough MA, Schofield CJ. Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors. Scientific Reports. 10: 8650. PMID 32457455 DOI: 10.1038/S41598-020-65123-9 |
0.593 |
|
| 2020 |
Brewitz L, Tumber A, Thalhammer A, Salah E, Christensen KE, Schofield CJ. Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase. Chemmedchem. PMID 32330361 DOI: 10.1002/Cmdc.202000147 |
0.409 |
|
| 2020 |
Brewitz L, Tumber A, Schofield CJ. Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing. The Journal of Biological Chemistry. 295: 7826-7838. PMID 32107312 DOI: 10.1074/Jbc.Ra119.012202 |
0.403 |
|
| 2020 |
Lu Z, Wang H, Zhang A, Liu X, Zhou W, Yang C, Guddat L, Yang H, Schofield CJ, Rao Z. Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation. Molecular Pharmacology. PMID 32086254 DOI: 10.1124/Mol.119.118042 |
0.328 |
|
| 2020 |
Singh A, Schofield CJ, Chen R. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Scientific Reports. 10: 1597. PMID 32005890 DOI: 10.1038/S41598-020-58482-W |
0.332 |
|
| 2020 |
Chaturvedi SS, Ramanan R, Lehnert N, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation. Acs Catalysis. 10: 1195-1209. PMID 31976154 DOI: 10.1021/Acscatal.9B04907 |
0.339 |
|
| 2020 |
Domene C, Jorgensen C, Schofield CJ. Mechanism of molecular oxygen diffusion in a hypoxia sensing prolyl hydroxylase using multiscale simulation. Journal of the American Chemical Society. PMID 31939292 DOI: 10.1021/Jacs.9B09236 |
0.383 |
|
| 2020 |
Bush JT, Chan MC, Mohammed S, Schofield C. Quantitative MS-based proteomics comparing the MCF-7 cellular response to hypoxia and a 2-oxoglutarate analogue. Chembiochem : a European Journal of Chemical Biology. PMID 31919953 DOI: 10.1002/Cbic.201900719 |
0.318 |
|
| 2020 |
Parkova A, Lucic A, Krajnc A, Brem J, Calvopina K, Langley GW, McDonough, Trapencieris P, Schofield CJ. Broad Spectrum beta-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. Acs Infectious Diseases. 6: 1398-1404. DOI: 10.2210/Pdb6Rpn/Pdb |
0.307 |
|
| 2020 |
Brewitz L, Tumber A, Nakashima Y, Schofield CJ. Novel 2‐Oxoglutarate Analogues Modulate the Epigenetic Activity of the Cancer‐related Human Enzyme Aspartate/Asparagine‐β‐Hydroxylase The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00468 |
0.339 |
|
| 2020 |
Ramanan R, Chaturvedi SS, Lehnert N, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control Chemical Science. DOI: 10.1039/D0Sc03713C |
0.396 |
|
| 2020 |
Tooke CL, Hinchliffe P, Krajnc A, Mulholland AJ, Brem J, Schofield CJ, Spencer J. Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition Rsc Medicinal Chemistry. 11: 491-496. DOI: 10.1039/C9Md00557A |
0.363 |
|
| 2020 |
Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, ... Schofield CJ, et al. A human protein hydroxylase that accepts D-residues Communications Chemistry. 3. DOI: 10.1038/s42004-020-0290-5 |
0.626 |
|
| 2019 |
Sulser P, Pickel C, Günter J, Leissing TM, Crean D, Schofield CJ, Wenger RH, Scholz CC. HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 2344-2358. PMID 31908020 DOI: 10.1096/Fj.201902240R |
0.352 |
|
| 2019 |
Parkova A, Lucic A, Krajnc A, Brem J, Calvopina K, Langley G, McDonough MA, Trapencieris P, Schofield CJ. Broad Spectrum β-lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. Acs Infectious Diseases. PMID 31841636 DOI: 10.1021/acsinfecdis.9b00330 |
0.504 |
|
| 2019 |
Reinbold R, John T, Spingardi P, Kawamura A, Thompson AL, Schofield CJ, Hopkinson RJ. Formaldehyde quantification using ampicillin is not selective. Scientific Reports. 9: 18289. PMID 31797955 DOI: 10.1038/S41598-019-54610-3 |
0.5 |
|
| 2019 |
Holt-Martyn J, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans C, Langley G, McDonough M, Pugh C, Ratcliffe P, Schofield C. Structure-Activity Relationship and Crystallographic Studies On 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem. PMID 31751494 DOI: 10.1002/Cmdc.201900557 |
0.791 |
|
| 2019 |
Smart TJ, Hamed RB, Claridge TDW, Schofield CJ. Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles. Bioorganic Chemistry. 103386. PMID 31706681 DOI: 10.1016/J.Bioorg.2019.103386 |
0.627 |
|
| 2019 |
Leśniak RK, Rydzik AM, Kamps JJAG, Kahn A, Claridge TDW, Schofield CJ. F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode. Chemical Communications (Cambridge, England). PMID 31702759 DOI: 10.1039/C9Cc06466D |
0.764 |
|
| 2019 |
Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature Communications. 10: 4910. PMID 31659163 DOI: 10.1038/S41467-019-12711-7 |
0.582 |
|
| 2019 |
Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans C, Schofield CJ, Padilla-Parra S, Siu SWI, Fry EE, Ren J, Stuart DI. Correction to "Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library". Journal of Medicinal Chemistry. PMID 31657917 DOI: 10.1021/Acs.Jmedchem.9B01711 |
0.659 |
|
| 2019 |
Lohans CT, Freeman EI, Groesen EV, Tooke CL, Hinchliffe P, Spencer J, Brem J, Schofield CJ. Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. Scientific Reports. 9: 13608. PMID 31541180 DOI: 10.1038/S41598-019-49264-0 |
0.676 |
|
| 2019 |
Li G, Su Y, Yan YH, Peng JY, Dai QQ, Ning XL, Zhu CL, Fu C, McDonough MA, Schofield CJ, Huang C, Li GB. MeLAD: an integrated resource for metalloenzyme-ligand associations. Bioinformatics (Oxford, England). PMID 31504189 DOI: 10.1093/Bioinformatics/Btz648 |
0.502 |
|
| 2019 |
Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ. Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. Elife. 8. PMID 31500697 DOI: 10.7554/Elife.46490 |
0.365 |
|
| 2019 |
Krajnc A, Brem J, Hinchliffe P, Calvopina K, Panduwawala T, Lang PA, Kamps JJAG, Tyrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. Journal of Medicinal Chemistry. PMID 31454231 DOI: 10.1021/Acs.Jmedchem.9B00911 |
0.364 |
|
| 2019 |
Tooke CL, Hinchliffe P, Lang PA, Mulholland AJ, Brem J, Schofield CJ, Spencer J. Molecular Basis of Class A β-lactamase Inhibition by Relebactam. Antimicrobial Agents and Chemotherapy. PMID 31383664 DOI: 10.1128/Aac.00564-19 |
0.354 |
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| 2019 |
de Munnik M, Lohans CT, Lang PA, Langley GW, Malla TR, Tumber A, Schofield CJ, Brem J. Targeting the Mycobacterium tuberculosis transpeptidase Ldt with cysteine-reactive inhibitors including ebselen. Chemical Communications (Cambridge, England). PMID 31380528 DOI: 10.1039/C9Cc04145A |
0.696 |
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| 2019 |
de Munnik M, Lohans CT, Langley GW, Bon C, Brem J, Schofield C. A Fluorescence-based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2. Chembiochem : a European Journal of Chemical Biology. PMID 31322798 DOI: 10.1002/Cbic.201900379 |
0.797 |
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| 2019 |
Admiraal SJ, Eyler DE, Baldwin MR, Brines EM, Lohans CT, Schofield CJ, O'Brien PJ. Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast. The Journal of Biological Chemistry. PMID 31320474 DOI: 10.1074/Jbc.Ra119.009813 |
0.65 |
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| 2019 |
van Groesen E, Lohans CT, Brem J, Aertker KM, Claridge TD, Schofield C. 19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31310409 DOI: 10.1002/Chem.201902529 |
0.677 |
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| 2019 |
Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, ... ... Schofield CJ, et al. The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. Acs Chemical Biology. PMID 31287655 DOI: 10.1021/Acschembio.9B00289 |
0.59 |
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| 2019 |
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Profiling interactions of vaborbactam with metallo-β-lactamases. Bioorganic & Medicinal Chemistry Letters. 29: 1981-1984. PMID 31171422 DOI: 10.1016/J.Bmcl.2019.05.031 |
0.328 |
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| 2019 |
Hamed RB, Gomez-Castellanos JR, Henry L, Warhaut S, Claridge TDW, Schofield CJ. Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases. Communications Chemistry. 2. PMID 31157308 DOI: 10.1038/s42004-018-0106-z |
0.597 |
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| 2019 |
Islam MS, McDonough MA, Chowdhury R, Gault J, Khan A, Pires E, Schofield CJ. Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. The Journal of Biological Chemistry. PMID 31147442 DOI: 10.1074/Jbc.Ra119.008693 |
0.706 |
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| 2019 |
Holt-Martyn JP, Tumber A, Rahman MZ, Lippl K, Figg W, McDonough MA, Chowdhury R, Schofield CJ. Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm. 10: 500-504. PMID 31057728 DOI: 10.1039/C8Md00548F |
0.688 |
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| 2019 |
Krajnc A, Lang PA, Panduwawala TD, Brem J, Schofield CJ. Will morphing boron-based inhibitors beat the β-lactamases? Current Opinion in Chemical Biology. 50: 101-110. PMID 31004962 DOI: 10.1016/J.Cbpa.2019.03.001 |
0.352 |
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| 2019 |
Chaturvedi SS, Ramanan R, Waheed SO, Ainsley J, Evison M, Ames JM, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases. Chemistry (Weinheim An Der Bergstrasse, Germany). 25: 5422-5426. PMID 30817054 DOI: 10.1002/Chem.201900492 |
0.365 |
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| 2019 |
Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans CT, Schofield CJ, Padilla-Parra S, Siu SWI, Fry E, Ren J, Stuart DI. Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library. Journal of Medicinal Chemistry. PMID 30785281 DOI: 10.1021/Acs.Jmedchem.8B01328 |
0.671 |
|
| 2019 |
Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J. Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates. Biochimica Et Biophysica Acta. General Subjects. PMID 30738906 DOI: 10.1016/J.Bbagen.2019.02.004 |
0.732 |
|
| 2019 |
Langley GW, Abboud MI, Lohans CT, Schofield CJ. Inhibition of a viral prolyl hydroxylase. Bioorganic & Medicinal Chemistry. PMID 30737136 DOI: 10.1016/J.Bmc.2019.01.018 |
0.683 |
|
| 2019 |
Waheed SO, Ramanan R, Chaturvedi SS, Ainsley J, Evison M, Ames JM, Schofield CJ, Christov CZ, Karabencheva-Christova TG. Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases. Organic & Biomolecular Chemistry. 17: 2223-2231. PMID 30720838 DOI: 10.1039/C9Ob00162J |
0.353 |
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| 2019 |
Nagy EZA, Tork SD, Lang PA, Filip A, Irimie FD, Poppe L, Toşa MI, Schofield CJ, Brem J, Paizs C, Bencze LC. Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum Acs Catalysis. 9: 8825-8834. DOI: 10.1021/Acscatal.9B02108 |
0.321 |
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| 2018 |
Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield C. Non-Hydrolytic β-Lactam Antibiotic Fragmentation by L,D-Transpeptidases and Serine β-Lactamase Cysteine Variants. Angewandte Chemie (International Ed. in English). PMID 30569575 DOI: 10.1002/Anie.201809424 |
0.7 |
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| 2018 |
Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal . Hypoxia (Auckland, N.Z.). 6: 57-71. PMID 30519597 DOI: 10.2147/Hp.S174655 |
0.778 |
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| 2018 |
Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. Elife. 7. PMID 30507380 DOI: 10.7554/Elife.39865 |
0.554 |
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| 2018 |
Bush JT, Leśniak RK, Yeh TL, Belle R, Kramer H, Tumber A, Chowdhury R, Flashman E, Mecinović J, Schofield CJ. Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture. Chemical Communications (Cambridge, England). PMID 30452037 DOI: 10.1039/C8Cc07706A |
0.807 |
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| 2018 |
Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J. Crystal Structures of VIM-1 Complexes Explain Active Site Heterogeneity in VIM-Class Metallo-β-Lactamases. The Febs Journal. PMID 30430727 DOI: 10.1111/Febs.14695 |
0.604 |
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| 2018 |
Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield C. Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30427558 DOI: 10.1002/Chem.201804790 |
0.805 |
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| 2018 |
Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N. A Fluorescent Benzo[g]isoquinoline-based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging. Chemmedchem. PMID 30380199 DOI: 10.1002/Cmdc.201800483 |
0.633 |
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| 2018 |
Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR. Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1. Jci Insight. 3. PMID 30333309 DOI: 10.1172/Jci.Insight.123196 |
0.315 |
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| 2018 |
Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X. Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively. Journal of Cell Science. PMID 30333145 DOI: 10.1242/Jcs.219782 |
0.331 |
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| 2018 |
Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ. Mechanistic and Structural Studies of KDM-Catalysed Demethylation of Histone 1 Isotype 4 at Lysine 26. Febs Letters. PMID 30156264 DOI: 10.1002/1873-3468.13231 |
0.658 |
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| 2018 |
Walport LJ, Schofield CJ. Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis. Chemical Record (New York, N.Y.). PMID 30151867 DOI: 10.1002/Tcr.201800056 |
0.357 |
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| 2018 |
Abboud M, Chowdhury R, Leung I, Lippl K, Loenarz C, Claridge TDW, Schofield C. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain. Chembiochem : a European Journal of Chemical Biology. PMID 30144273 DOI: 10.1002/Cbic.201800246 |
0.789 |
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| 2018 |
Guillade L, Sarno F, Tarhnskaya H, Nebbioso A, Alvarez S, Kawamura A, Schofield C, Altucci L, de Lera AR. Synthesis and biological evaluation of tripartin, a putative KDM4 natural product inhibitor, and 1-dichloromethylinden-1-ol analogues. Chemmedchem. PMID 30047603 DOI: 10.1002/Cmdc.201800377 |
0.566 |
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| 2018 |
Tarhonskaya H, Tumber A, Kawamura A, Schofield CJ. In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs). Current Protocols in Pharmacology. 80: 3.15.1-3.15.12. PMID 30040204 DOI: 10.1002/Cpph.34 |
0.559 |
|
| 2018 |
Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD. Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models. Marine Drugs. 16. PMID 30029505 DOI: 10.3390/Md16070241 |
0.325 |
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| 2018 |
Schofield CJ. Symmetry breaking by enzyme-catalyzed epoxide hydrolysis. Iucrj. 5: 373-374. PMID 30002837 DOI: 10.1107/S2052252518007005 |
0.344 |
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| 2018 |
Hopkinson RJ, Langley GW, Belle R, Walport LJ, Dunne K, Münzel M, Salah E, Kawamura A, Claridge TDW, Schofield CJ. Human histone demethylase KDM6B can catalyse sequential oxidations. Chemical Communications (Cambridge, England). PMID 29961803 DOI: 10.1039/C8Cc04057E |
0.554 |
|
| 2018 |
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Schofield CJ, et al. Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. PMID 29950663 DOI: 10.1038/S41589-018-0104-6 |
0.765 |
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| 2018 |
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Schofield CJ, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. 14: 688-695. PMID 29915238 DOI: 10.1038/S41589-018-0071-Y |
0.816 |
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| 2018 |
McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, ... ... Schofield CJ, et al. Non-competitive cyclic peptides for targeting enzyme-substrate complexes. Chemical Science. 9: 4569-4578. PMID 29899950 DOI: 10.1039/C8Sc00286J |
0.751 |
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| 2018 |
Rabe P, Kamps JJAG, Schofield CJ, Lohans CT. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis. Natural Product Reports. PMID 29808887 DOI: 10.1039/C8Np00002F |
0.694 |
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| 2018 |
Shishodia S, Zhang D, El-Sagheer AH, Brown T, Claridge TDW, Schofield CJ, Hopkinson RJ. NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases. Organic & Biomolecular Chemistry. PMID 29767200 DOI: 10.1039/C8Ob00734A |
0.344 |
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| 2018 |
Bhushan B, Erdmann A, Zhang Y, Belle R, Johannson C, Oppermann U, Hopkinson RJ, Schofield CJ, Kawamura A. Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorganic & Medicinal Chemistry. PMID 29764755 DOI: 10.1016/J.Bmc.2018.03.030 |
0.573 |
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| 2018 |
Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase. Nature Communications. 9: 1675. PMID 29686330 DOI: 10.1038/S41467-018-04196-7 |
0.483 |
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| 2018 |
Bonnici J, Tumber A, Kawamura A, Schofield CJ. Inhibitors of both the -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29685975 DOI: 10.1098/Rstb.2017.0071 |
0.582 |
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| 2018 |
Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases. Bioorganic & Medicinal Chemistry. PMID 29655609 DOI: 10.1016/J.Bmc.2018.02.043 |
0.808 |
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| 2018 |
Brennan P, Bowkett D, Talon R, Tallant C, Schofield C, Bruton G, von Delft F, Knapp S. Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces. Chemmedchem. PMID 29578648 DOI: 10.1002/Cmdc.201800030 |
0.328 |
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| 2018 |
Wilkins SE, Islam S, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. JMJD5 is a human arginyl C-3 hydroxylase. Nature Communications. 9: 1180. PMID 29563586 DOI: 10.1038/S41467-018-03410-W |
0.602 |
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| 2018 |
Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. YcfDis a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase. Extremophiles : Life Under Extreme Conditions. PMID 29523972 DOI: 10.1007/S00792-018-1016-9 |
0.739 |
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| 2018 |
Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinović J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ. 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2. Chemical Communications (Cambridge, England). PMID 29522057 DOI: 10.1039/C8Cc00387D |
0.803 |
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| 2018 |
Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ. 2-Oxoglutarate-Dependent Oxygenases. Annual Review of Biochemistry. PMID 29494239 DOI: 10.1146/Annurev-Biochem-061516-044724 |
0.553 |
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| 2018 |
Hancock RL, Abboud MI, Smart TJ, Flashman E, Kawamura A, Schofield CJ, Hopkinson R. Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation. Chembiochem : a European Journal of Chemical Biology. PMID 29443450 DOI: 10.1002/Cbic.201800002 |
0.552 |
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| 2018 |
Strope JD, Harris EM, Beedie SL, Chau CH, Cook KM, Schofield CJ, Gustafson KR, Figg WD. Abstract 14: Preclinical evaluation of novel HIF-1α/P300 binding inhibitors Cancer Research. 78: 14-14. DOI: 10.1158/1538-7445.Am2018-14 |
0.328 |
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| 2018 |
Zhang C, Pu Y, Yu Z, Wu C, Brem J, McDonough MA, Schofield CJ, Li G, Wu Y. Rh(iii)-Catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases Organic Chemistry Frontiers. 5: 1288-1292. DOI: 10.1039/C8Qo00009C |
0.549 |
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| 2017 |
Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, ... ... Schofield CJ, et al. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical Science. 8: 7651-7668. PMID 29435217 DOI: 10.1039/C7Sc02103H |
0.819 |
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| 2017 |
Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh P, Schofield CJ, Fishwick CWG. In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors. Journal of Medicinal Chemistry. PMID 29271657 DOI: 10.1021/Acs.Jmedchem.7B01728 |
0.603 |
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| 2017 |
Abboud MI, Kosmopoulou M, Krismanich A, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield C, Dmitrienko GI. Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29250863 DOI: 10.1002/Chem.201705886 |
0.349 |
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| 2017 |
Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield C. A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems via Lactone Formation. Angewandte Chemie (International Ed. in English). PMID 29236332 DOI: 10.1002/Anie.201711308 |
0.685 |
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| 2017 |
Belle R, Al Temimi AHK, Kumar K, Pieters BJGE, Tumber A, Dunford JE, Johansson C, Oppermann U, Brown T, Schofield CJ, Hopkinson RJ, Paton RS, Kawamura A, Mecinović J. Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition. Chemical Communications (Cambridge, England). 53: 13264-13267. PMID 29186216 DOI: 10.1039/C7Cc08028J |
0.714 |
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| 2017 |
Lohans CT, Brem J, Schofield CJ. New Delhi metallo-β-lactamase-1 catalyses avibactam and aztreonam hydrolysis. Antimicrobial Agents and Chemotherapy. PMID 28971873 DOI: 10.1128/Aac.01224-17 |
0.654 |
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| 2017 |
Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Molecular Microbiology. PMID 28876489 DOI: 10.1111/Mmi.13831 |
0.689 |
|
| 2017 |
Tarhonskaya H, Nowak RP, Johansson C, Szykowska A, Tumber A, Hancock RL, Lang P, Flashman E, Oppermann U, Schofield CJ, Kawamura A. Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates. Journal of Molecular Biology. PMID 28827149 DOI: 10.1016/J.Jmb.2017.08.007 |
0.58 |
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| 2017 |
McNeill L, Brown T, Sami M, Clifton I, Burzlaff N, Claridge T, Adlington R, Baldwin J, Rutledge PJ, Schofield C. Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate and a new mode of reaction for non-heme iron oxidases. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28703303 DOI: 10.1002/Chem.201701592 |
0.818 |
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| 2017 |
Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ. (13)C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions. Organic & Biomolecular Chemistry. PMID 28678295 DOI: 10.1039/C7Ob01514C |
0.805 |
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| 2017 |
Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor. Kidney International. PMID 28506759 DOI: 10.1016/J.Kint.2017.03.008 |
0.408 |
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| 2017 |
Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ. Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition. Chemical Communications (Cambridge, England). PMID 28470248 DOI: 10.1039/C7Cc02394D |
0.804 |
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| 2017 |
Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ. NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors. Chemical Science. 8: 928-937. PMID 28451231 DOI: 10.1039/C6Sc04524C |
0.756 |
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| 2017 |
Zhang Z, Smart TJ, Choi H, Hardy F, Lohans CT, Abboud MI, Richardson MSW, Paton RS, McDonough MA, Schofield CJ. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate. Proceedings of the National Academy of Sciences of the United States of America. PMID 28420789 DOI: 10.1073/Pnas.1617760114 |
0.747 |
|
| 2017 |
Kawamura A, Münzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Müller S, Brennan PE, ... ... Schofield CJ, et al. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nature Communications. 8: 14773. PMID 28382930 DOI: 10.1038/Ncomms14773 |
0.76 |
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| 2017 |
Hatch SB, Yapp C, Montenegro RC, Savitsky P, Gamble V, Tumber A, Ruda GF, Bavetsias V, Fedorov O, Atrash B, Raynaud F, Lanigan R, Carmichael L, Tomlin K, Burke R, ... ... Schofield CJ, et al. Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics & Chromatin. 10: 9. PMID 28265301 DOI: 10.1186/S13072-017-0116-6 |
0.532 |
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| 2017 |
Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, ... ... Schofield CJ, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chemical Biology. PMID 28262558 DOI: 10.1016/J.Chembiol.2017.02.006 |
0.566 |
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| 2017 |
Abboud MI, Hinchliffe P, Brem J, Macsics R, Pfeffer I, Makena A, Umland KD, Rydzik AM, Li GB, Spencer J, Claridge TD, Schofield CJ. (19) F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase. Angewandte Chemie (International Ed. in English). PMID 28252254 DOI: 10.1002/Anie.201612185 |
0.343 |
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| 2017 |
Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, et al. KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability. The Journal of Cell Biology. PMID 28246120 DOI: 10.1083/Jcb.201607032 |
0.483 |
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| 2017 |
Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J. Cyclic Boronates Inhibit All Classes of β-Lactamase. Antimicrobial Agents and Chemotherapy. PMID 28115348 DOI: 10.1128/Aac.02260-16 |
0.749 |
|
| 2017 |
Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, ... Schofield CJ, et al. Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1. Scientific Reports. 7: 39392. PMID 28059088 DOI: 10.1038/Srep39392 |
0.32 |
|
| 2017 |
Lohans CT, Wang DY, Wang J, Hamed RB, Schofield CJ. Crotonases: Nature’s Exceedingly Convertible Catalysts Acs Catalysis. 7: 6587-6599. DOI: 10.1021/Acscatal.7B01699 |
0.774 |
|
| 2017 |
Hamed RB, Henry L, Claridge TDW, Schofield CJ. Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes Acs Catalysis. 7: 1279-1285. DOI: 10.1021/Acscatal.6B02509 |
0.616 |
|
| 2017 |
Abuhammad A, McDonough MA, Brem J, Makena A, Johnson S, Schofield CJ, Garman EF. “To Cross-Seed or Not To Cross-Seed”: A Pilot Study Using Metallo-β-lactamases Crystal Growth & Design. 17: 913-924. DOI: 10.1021/Acs.Cgd.6B01805 |
0.531 |
|
| 2016 |
Leśniak RK, Markolovic S, Tars K, Schofield CJ. Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N(ε)-trimethyllysine. Chemical Communications (Cambridge, England). PMID 27965989 DOI: 10.1039/C6Cc08381A |
0.755 |
|
| 2016 |
Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nature Communications. 7: 12673. PMID 27561929 DOI: 10.1038/Ncomms12673 |
0.705 |
|
| 2016 |
Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ. Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases. The Journal of Biological Chemistry. PMID 27502280 DOI: 10.1074/Jbc.M116.749291 |
0.354 |
|
| 2016 |
Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nature Communications. 7: 12406. PMID 27499424 DOI: 10.1038/Ncomms12406 |
0.713 |
|
| 2016 |
Cahill ST, Tarhonskaya H, Rydzik AM, Flashman E, McDonough MA, Schofield CJ, Brem J. Use of ferrous iron by metallo-β-lactamases. Journal of Inorganic Biochemistry. PMID 27498591 DOI: 10.1016/J.Jinorgbio.2016.07.013 |
0.547 |
|
| 2016 |
Salimraj R, Zhang L, Hinchliffe P, Wellington EM, Brem J, Schofield CJ, Gaze WH, Spencer J. Structural and Biochemical Characterization of Rm3, a SubClass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study. Antimicrobial Agents and Chemotherapy. PMID 27431213 DOI: 10.1128/Aac.00750-16 |
0.327 |
|
| 2016 |
Abboud MI, Damblon C, Brem J, Smargiasso N, Mercuri P, Gilbert B, Rydzik AM, Claridge TD, Schofield CJ, Frère JM. Interaction of Avibactam with Class B Metallo-β-lactamases. Antimicrobial Agents and Chemotherapy. PMID 27401561 DOI: 10.1128/Aac.00897-16 |
0.334 |
|
| 2016 |
Walport LJ, Hopkinson RJ, Chowdhury R, Schiller R, Ge W, Kawamura A, Schofield CJ. Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nature Communications. 7: 11974. PMID 27337104 DOI: 10.1038/Ncomms11974 |
0.679 |
|
| 2016 |
Wang DY, Abboud MI, Markoulides MS, Brem J, Schofield CJ. The road to avibactam - the first clinically useful non-β-lactam working somewhat like a β-lactam. Future Medicinal Chemistry. PMID 27327972 DOI: 10.4155/Fmc-2016-0078 |
0.785 |
|
| 2016 |
Markolovic S, Leissing TM, Chowdhury R, Wilkins SE, Lu X, Schofield CJ. Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases. Current Opinion in Structural Biology. 41: 62-72. PMID 27309310 DOI: 10.1016/J.Sbi.2016.05.013 |
0.572 |
|
| 2016 |
Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB. Sideromimic modification of Lactivicin dramatically increases potency against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Antimicrobial Agents and Chemotherapy. PMID 27139464 DOI: 10.1128/Aac.00371-16 |
0.319 |
|
| 2016 |
Lee SY, Brem J, Pettinati I, Claridge TD, Gileadi O, Schofield CJ, McHugh PJ. Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo. Chemical Communications (Cambridge, England). PMID 27121860 DOI: 10.1039/C6Cc00529B |
0.335 |
|
| 2016 |
Choi H, Paton RS, Park H, Schofield CJ. Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition. Organic & Biomolecular Chemistry. PMID 27072755 DOI: 10.1039/C6Ob00353B |
0.364 |
|
| 2016 |
Wilkins SE, Abboud MI, Hancock RL, Schofield CJ. Targeting Protein-Protein Interactions in the HIF System. Chemmedchem. PMID 26997519 DOI: 10.1002/Cmdc.201600012 |
0.329 |
|
| 2016 |
Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, ... ... Schofield CJ, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine. 8: 328ra29. PMID 26936506 DOI: 10.1126/Scitranslmed.Aac6008 |
0.315 |
|
| 2016 |
Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ. The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins. Trends in Biochemical Sciences. PMID 26805042 DOI: 10.1016/J.Tibs.2015.12.007 |
0.38 |
|
| 2016 |
Chan MC, Holt-Martyn JP, Schofield CJ, Ratcliffe PJ. Pharmacological targeting of the HIF hydroxylases - a new field in medicine development. Molecular Aspects of Medicine. PMID 26791432 DOI: 10.1016/J.Mam.2016.01.001 |
0.372 |
|
| 2016 |
Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, ... ... Schofield CJ, et al. 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. Journal of Medicinal Chemistry. PMID 26741168 DOI: 10.1021/Acs.Jmedchem.5B01635 |
0.576 |
|
| 2016 |
Khan A, Leśniak RK, Brem J, Rydzik AM, Choi H, Leung IKH, McDonough MA, Schofield CJ, Claridge TDW. Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase Medchemcomm. 7: 873-880. DOI: 10.1039/C6Md00004E |
0.788 |
|
| 2016 |
Kamps JJAG, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TDW, Mecinović J. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis Chemistry - a European Journal. 22. DOI: 10.1002/Chem.201680462 |
0.778 |
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| 2015 |
González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ. Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase. Acs Infectious Diseases. 1: 544-54. PMID 27623409 DOI: 10.1021/Acsinfecdis.5B00046 |
0.367 |
|
| 2015 |
Hamed RB, Gomez-Castellanos JR, Froese DS, Krysztofinska E, Yue WW, Schofield CJ. Use of Methylmalonyl-CoA epimerase in Enhancing Crotonase Stereoselectivity. Chembiochem : a European Journal of Chemical Biology. PMID 26716911 DOI: 10.1002/Cbic.201500644 |
0.603 |
|
| 2015 |
McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ. Recent Progress in Histone Demethylase Inhibitors. Journal of Medicinal Chemistry. PMID 26710088 DOI: 10.1021/Acs.Jmedchem.5B01758 |
0.798 |
|
| 2015 |
Hopkinson RJ, Leung IK, Smart TJ, Rose NR, Henry L, Claridge TD, Schofield CJ. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans. Plos One. 10: e0145085. PMID 26675168 DOI: 10.1371/Journal.Pone.0145085 |
0.58 |
|
| 2015 |
Makena A, Düzgün AÖ, Brem J, McDonough MA, Rydzik AM, Abboud MI, Saral A, Çiçek AÇ, Sandalli C, Schofield CJ. Comparison of Verona Integron-Borne Metallo-β-lactamase Variants Reveals Differences in Stability and Inhibition Profiles. Antimicrobial Agents and Chemotherapy. PMID 26666919 DOI: 10.1128/Aac.01768-15 |
0.57 |
|
| 2015 |
Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinović J. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26660433 DOI: 10.1002/Chem.201503761 |
0.804 |
|
| 2015 |
Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O. The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. Nucleic Acids Research. PMID 26582912 DOI: 10.1093/Nar/Gkv1256 |
0.323 |
|
| 2015 |
Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, MacKerell A. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor. Journal of Chemical Theory and Computation. 11: 3946-54. PMID 26574473 DOI: 10.1021/Acs.Jctc.5B00411 |
0.359 |
|
| 2015 |
Langley GW, Brinkø A, Münzel M, Walport LJ, Schofield CJ, Hopkinson RJ. Analysis of JmjC Demethylase-Catalysed Demethylation using Geometrically-Constrained Lysine Analogues. Acs Chemical Biology. PMID 26555343 DOI: 10.1021/Acschembio.5B00738 |
0.377 |
|
| 2015 |
Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ. Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers. Antimicrobial Agents and Chemotherapy. PMID 26482303 DOI: 10.1128/Aac.01335-15 |
0.587 |
|
| 2015 |
Daoud H, Zhang D, McMurray F, Yu A, Luco SM, Vanstone J, Jarinova O, Carson N, Wickens J, Shishodia S, Choi H, McDonough MA, Schofield CJ, Harper ME, Dyment DA, et al. Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay. Journal of Medical Genetics. PMID 26378117 DOI: 10.1136/Jmedgenet-2015-103399 |
0.49 |
|
| 2015 |
Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase. Biochemistry. 54: 6093-105. PMID 26368022 DOI: 10.1021/Acs.Biochem.5B00789 |
0.734 |
|
| 2015 |
Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, ... ... Schofield CJ, et al. Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Chemical Communications (Cambridge, England). 51: 15458-61. PMID 26345662 DOI: 10.1039/C5Cc06095H |
0.573 |
|
| 2015 |
Al-Qahtani K, Jabeen B, Sekirnik R, Riaz N, Claridge TD, Schofield CJ, McCullagh JS. The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. Phytochemistry. 117: 456-461. PMID 26196940 DOI: 10.1016/J.Phytochem.2015.06.028 |
0.387 |
|
| 2015 |
Markolovic S, Wilkins SE, Schofield CJ. Protein Hydroxylation Catalyzed by 2-Oxoglutarate-Dependent Oxygenases. The Journal of Biological Chemistry. PMID 26152730 DOI: 10.1074/Jbc.R115.662627 |
0.397 |
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| 2015 |
Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, ... ... Schofield CJ, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. Plos One. 10: e0132004. PMID 26147748 DOI: 10.1371/Journal.Pone.0132004 |
0.664 |
|
| 2015 |
Ghavami A, Labbé G, Brem J, Goodfellow VJ, Marrone L, Tanner CA, King DT, Lam M, Strynadka NC, Pillai DR, Siemann S, Spencer J, Schofield CJ, Dmitrienko GI. Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates. Analytical Biochemistry. PMID 26142222 DOI: 10.1016/J.Ab.2015.06.032 |
0.309 |
|
| 2015 |
Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-Inducible Factor (FIH) as an Oxygen Sensor. The Journal of Biological Chemistry. PMID 26112411 DOI: 10.1074/Jbc.M115.653014 |
0.568 |
|
| 2015 |
Plank M, Fischer R, Geoghegan V, Charles PD, Konietzny R, Acuto O, Pears C, Schofield CJ, Kessler BM. Expanding the yeast protein arginine methylome. Proteomics. PMID 26046779 DOI: 10.1002/Pmic.201500032 |
0.321 |
|
| 2015 |
Böttger A, Islam MS, Chowdhury R, Schofield CJ, Wolf A. The oxygenase Jmjd6--a case study in conflicting assignments. The Biochemical Journal. 468: 191-202. PMID 25997831 DOI: 10.1042/Bj20150278 |
0.681 |
|
| 2015 |
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. Pharmacological inhibition of FTO. Plos One. 10: e0121829. PMID 25830347 DOI: 10.1371/Journal.Pone.0121829 |
0.525 |
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| 2015 |
Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure (London, England : 1993). 23: 639-52. PMID 25728928 DOI: 10.1016/J.Str.2015.01.014 |
0.787 |
|
| 2015 |
Brem J, Struwe WB, Rydzik AM, Tarhonskaya H, Pfeffer I, Flashman E, van Berkel SS, Spencer J, Claridge TD, McDonough MA, Benesch JL, Schofield CJ. Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, (19)F-labelling, crystallisation, data collection, and structure determination, table of crystallographic data, table of crystallographic parameters and refinement statistics, figures showing binding mode and distances, procedures for mass spectrometry measurements, differential scanning fluorimetry measurements, stopped-flow measurements and other kinetics measurements. See DOI: 10.1039/c4sc01752hClick here for additional data file. Chemical Science (Royal Society of Chemistry : 2010). 6: 956-963. PMID 25717359 DOI: 10.1039/C4Sc01752H |
0.551 |
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| 2015 |
Zafred D, Steiner B, Teufelberger AR, Hromic A, Karplus PA, Schofield CJ, Wallner S, Macheroux P. Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction. The Febs Journal. PMID 25619330 DOI: 10.1111/Febs.13212 |
0.377 |
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| 2015 |
Pettinati I, Brem J, McDonough MA, Schofield CJ. Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Human Molecular Genetics. 24: 2458-69. PMID 25596185 DOI: 10.1093/Hmg/Ddv007 |
0.586 |
|
| 2015 |
Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ. Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion. Diabetes. 64: 733-45. PMID 25377876 DOI: 10.2337/Db14-0233 |
0.312 |
|
| 2015 |
Makena A, Brem J, Pfeffer I, Geffen RE, Wilkins SE, Tarhonskaya H, Flashman E, Phee LM, Wareham DW, Schofield CJ. Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability. The Journal of Antimicrobial Chemotherapy. 70: 463-9. PMID 25324420 DOI: 10.1093/Jac/Dku403 |
0.323 |
|
| 2015 |
Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD. Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). European Journal of Medicinal Chemistry. 94: 509-16. PMID 25023609 DOI: 10.1016/J.Ejmech.2014.06.006 |
0.592 |
|
| 2015 |
Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Sinha A, Hitomi T, Habu T, Koizumi A, Wilkins S, Kislinger T, Schofield CJ, Dennis JW, et al. Abstract LB-302: PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase activity to allow breast tumor survival in hypoxia Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-302 |
0.3 |
|
| 2015 |
Hay DA, Rogers CM, Fedorov O, Tallant C, Martin S, Monteiro OP, Müller S, Knapp S, Schofield CJ, Brennan PE. Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains Medchemcomm. 6: 1381-1386. DOI: 10.1039/C5Md00152H |
0.337 |
|
| 2015 |
Wilkins SE, Flashman E, Scotti JS, Hopkinson RJ, Chowdhury R, Schofield CJ. The role of 2-oxoglutarate-dependent oxygenases in hypoxia sensing Rsc Metallobiology. 2015: 169-209. DOI: 10.1039/9781782621959-00169 |
0.458 |
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| 2015 |
Aik WS, Chowdhury R, Clifton IJ, Hopkinson RJ, Leissing T, McDonough MA, Nowak R, Schofield CJ, Walport LJ. Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes Rsc Metallobiology. 2015: 59-94. DOI: 10.1039/9781782621959-00059 |
0.732 |
|
| 2014 |
Gardie B, Percy MJ, Hoogewijs D, Chowdhury R, Bento C, Arsenault PR, Richard S, Almeida H, Ewing J, Lambert F, McMullin MF, Schofield CJ, Lee FS. The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia (Auckland, N.Z.). 2: 71-90. PMID 27774468 DOI: 10.2147/Hp.S54455 |
0.542 |
|
| 2014 |
Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. Chemical Science (Royal Society of Chemistry : 2010). 5: 1765-1771. PMID 26682037 DOI: 10.1039/C4Sc00020J |
0.755 |
|
| 2014 |
England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, von Delft F, Burgess-Brown NA, Kawamura A, Schofield CJ, Brennan PE. Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. Medchemcomm. 5: 1879-1886. PMID 26682034 DOI: 10.1039/C4Md00291A |
0.555 |
|
| 2014 |
Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A. Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates. Epigenetics. 9: 1596-603. PMID 25625844 DOI: 10.4161/15592294.2014.983381 |
0.69 |
|
| 2014 |
Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. Nature Chemistry. 6: 1084-90. PMID 25411887 DOI: 10.1038/Nchem.2110 |
0.689 |
|
| 2014 |
Rydzik AM, Brem J, Struwe WB, Kochan GT, Benesch JL, Schofield CJ. Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase. Bioorganic & Medicinal Chemistry Letters. 24: 4954-7. PMID 25266780 DOI: 10.1016/J.Bmcl.2014.09.035 |
0.388 |
|
| 2014 |
Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, Horita S, Ho CH, Kershaw NJ, ... ... Schofield CJ, et al. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 13331-6. PMID 25197067 DOI: 10.1073/Pnas.1409916111 |
0.598 |
|
| 2014 |
Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ. Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids. Angewandte Chemie (International Ed. in English). 53: 10925-7. PMID 25164544 DOI: 10.1002/Anie.201406125 |
0.537 |
|
| 2014 |
Tarhonskaya H, Chowdhury R, Leung IK, Loik ND, McCullagh JS, Claridge TD, Schofield CJ, Flashman E. Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen. The Biochemical Journal. 463: 363-72. PMID 25120187 DOI: 10.1042/Bj20140779 |
0.561 |
|
| 2014 |
Rydzik AM, Leung IK, Kochan GT, Loik ND, Henry L, McDonough MA, Claridge TD, Schofield CJ. Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase. Organic & Biomolecular Chemistry. 12: 6354-8. PMID 25030770 DOI: 10.1039/C4Ob01167H |
0.576 |
|
| 2014 |
Hay DA, Fedorov O, Martin S, Singleton DC, Tallant C, Wells C, Picaud S, Philpott M, Monteiro OP, Rogers CM, Conway SJ, Rooney TP, Tumber A, Yapp C, Filippakopoulos P, ... ... Schofield CJ, et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. Journal of the American Chemical Society. 136: 9308-19. PMID 24946055 DOI: 10.1021/Ja412434F |
0.333 |
|
| 2014 |
Heim A, Grimm C, Müller U, Häußler S, Mackeen MM, Merl J, Hauck SM, Kessler BM, Schofield CJ, Wolf A, Böttger A. Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins. Nucleic Acids Research. 42: 7833-50. PMID 24914048 DOI: 10.1093/Nar/Gku488 |
0.733 |
|
| 2014 |
Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. Targeting histone lysine demethylases - progress, challenges, and the future. Biochimica Et Biophysica Acta. 1839: 1416-32. PMID 24859458 DOI: 10.1016/J.Bbagrm.2014.05.009 |
0.668 |
|
| 2014 |
Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, ... ... Schofield CJ, et al. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature. 510: 422-6. PMID 24814345 DOI: 10.1038/Nature13263 |
0.778 |
|
| 2014 |
Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C. Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase. The Journal of Biological Chemistry. 289: 18302-13. PMID 24798337 DOI: 10.1074/Jbc.M114.555052 |
0.407 |
|
| 2014 |
Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. The Journal of Biological Chemistry. 289: 17299-311. PMID 24778178 DOI: 10.1074/Jbc.M114.550350 |
0.309 |
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| 2014 |
Tarhonskaya H, Szöllössi A, Leung IK, Bush JT, Henry L, Chowdhury R, Iqbal A, Claridge TD, Schofield CJ, Flashman E. Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases. Biochemistry. 53: 2483-93. PMID 24684493 DOI: 10.1021/Bi500086P |
0.585 |
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| 2014 |
Rydzik AM, Brem J, van Berkel SS, Pfeffer I, Makena A, Claridge TD, Schofield CJ. Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy. Angewandte Chemie (International Ed. in English). 53: 3129-33. PMID 24615874 DOI: 10.1002/Anie.201310866 |
0.319 |
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| 2014 |
Tarhonskaya H, Rydzik AM, Leung IK, Loik ND, Chan MC, Kawamura A, McCullagh JS, Claridge TD, Flashman E, Schofield CJ. Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. Nature Communications. 5: 3423. PMID 24594748 DOI: 10.1038/Ncomms4423 |
0.557 |
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| 2014 |
Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F. Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. Plos One. 9: e88955. PMID 24563687 DOI: 10.1371/Journal.Pone.0088955 |
0.329 |
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| 2014 |
Katz MJ, Acevedo JM, Loenarz C, Galagovsky D, Liu-Yi P, Pérez-Pepe M, Thalhammer A, Sekirnik R, Ge W, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman ME, et al. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proceedings of the National Academy of Sciences of the United States of America. 111: 4025-30. PMID 24550463 DOI: 10.1073/Pnas.1314485111 |
0.706 |
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| 2014 |
Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proceedings of the National Academy of Sciences of the United States of America. 111: 4019-24. PMID 24550462 DOI: 10.1073/Pnas.1311750111 |
0.808 |
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| 2014 |
Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, ... ... Schofield CJ, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 4031-6. PMID 24550447 DOI: 10.1073/Pnas.1314482111 |
0.768 |
|
| 2014 |
Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC, Mott BT, McCullagh JS, Maloney DJ, Schofield CJ, Kawamura A. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. Chemmedchem. 9: 566-71. PMID 24504543 DOI: 10.1002/Cmdc.201300428 |
0.696 |
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| 2014 |
Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA. Structure of human RNA Nâ¶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Research. 42: 4741-54. PMID 24489119 DOI: 10.1093/Nar/Gku085 |
0.594 |
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| 2014 |
Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, ... ... Schofield CJ, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Molecular Cell. 53: 645-54. PMID 24486019 DOI: 10.1016/J.Molcel.2013.12.028 |
0.338 |
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| 2014 |
Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ON, ... ... Schofield CJ, et al. Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. Journal of Medicinal Chemistry. 57: 42-55. PMID 24325601 DOI: 10.1021/Jm4012802 |
0.664 |
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| 2014 |
Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chemical Communications (Cambridge, England). 50: 1794-6. PMID 24287551 DOI: 10.1039/C3Cc48151D |
0.541 |
|
| 2014 |
Horita S, Scotti J, McDonough M, Sekirnik R, Chowdhury R, Krojer T, Thalhammer A, Aik W, Oppermann U, Schofield C. Crystal structures of 2OG oxygenases involved in ribosomal protein hydroxylation Acta Crystallographica Section a Foundations and Advances. 70: C304-C304. DOI: 10.1107/S2053273314096958 |
0.572 |
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| 2014 |
Abuhammad A, McDonough M, Brem J, Schofield C, Garman E. "From one seed a whole handful": homologous proteins as seeds in crystallisation Acta Crystallographica Section a Foundations and Advances. 70: C1144-C1144. DOI: 10.1107/S205327331408855X |
0.524 |
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| 2014 |
Aik WS, Demetriades M, Schofield C, McDonough M. Structures of human m6A RNA demethylases: FTO and ALKBH5 Acta Crystallographica Section a Foundations and Advances. 70: C1392-C1392. DOI: 10.1107/S2053273314086070 |
0.546 |
|
| 2014 |
Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis-selective inhibition of γ-butyrobetaine hydroxylase Chemical Science. 5: 1765-1771. DOI: 10.1039/c4sc00020j |
0.689 |
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| 2014 |
England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, Von Delft F, Burgess-Brown NA, Kawamura A, Schofield CJ, Brennan PE. Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor Medchemcomm. 5: 1879-1886. DOI: 10.1039/c4md00291a |
0.483 |
|
| 2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Schofield CJ, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3Sc51122G |
0.811 |
|
| 2013 |
Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ. Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition. Chemmedchem. 8: 1923-9. PMID 24166830 DOI: 10.1002/Cmdc.201300350 |
0.6 |
|
| 2013 |
Hamed RB, Henry L, Gomez-Castellanos JR, Asghar A, Brem J, Claridge TD, Schofield CJ. Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase. Organic & Biomolecular Chemistry. 11: 8191-6. PMID 24108359 DOI: 10.1039/C3Ob41525B |
0.615 |
|
| 2013 |
Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA, Brown R, Fuchter MJ. On the histone lysine methyltransferase activity of fungal metabolite chaetocin. Journal of Medicinal Chemistry. 56: 8616-25. PMID 24099080 DOI: 10.1021/Jm401063R |
0.381 |
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| 2013 |
Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, ... ... Schofield CJ, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. Journal of Medicinal Chemistry. 56: 7222-31. PMID 23964788 DOI: 10.1021/Jm400624B |
0.567 |
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| 2013 |
van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. Binding of (5S)-penicilloic acid to penicillin binding protein 3. Acs Chemical Biology. 8: 2112-6. PMID 23899657 DOI: 10.1021/Cb400200H |
0.597 |
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| 2013 |
van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. Assay platform for clinically relevant metallo-β-lactamases. Journal of Medicinal Chemistry. 56: 6945-53. PMID 23898798 DOI: 10.1021/Jm400769B |
0.325 |
|
| 2013 |
Valegård K, Iqbal A, Kershaw NJ, Ivison D, Généreux C, Dubus A, Blikstad C, Demetriades M, Hopkinson RJ, Lloyd AJ, Roper DI, Schofield CJ, Andersson I, McDonough MA. Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallographica. Section D, Biological Crystallography. 69: 1567-79. PMID 23897479 DOI: 10.1107/S0907444913011013 |
0.585 |
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| 2013 |
Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ. Is JmjC oxygenase catalysis limited to demethylation? Angewandte Chemie (International Ed. in English). 52: 7709-13. PMID 23788451 DOI: 10.1002/Anie.201303282 |
0.685 |
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| 2013 |
Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ. Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. The Journal of Physiology. 591: 3565-77. PMID 23690557 DOI: 10.1113/Jphysiol.2012.247254 |
0.307 |
|
| 2013 |
Wolf A, Mantri M, Heim A, Müller U, Fichter E, Mackeen MM, Schermelleh L, Dadie G, Leonhardt H, Vénien-Bryan C, Kessler BM, Schofield CJ, Böttger A. The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. The Biochemical Journal. 453: 357-70. PMID 23688307 DOI: 10.1042/Bj20130529 |
0.73 |
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| 2013 |
Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, ... ... Schofield CJ, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. Acs Chemical Biology. 8: 1488-96. PMID 23683440 DOI: 10.1021/Cb400088Q |
0.785 |
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| 2013 |
Aik W, Demetriades M, Hamdan MK, Bagg EA, Yeoh KK, Lejeune C, Zhang Z, McDonough MA, Schofield CJ. Structural basis for inhibition of the fat mass and obesity associated protein (FTO). Journal of Medicinal Chemistry. 56: 3680-8. PMID 23547775 DOI: 10.1021/Jm400193D |
0.691 |
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| 2013 |
Sarathi Addy P, Saha B, Pradeep Singh ND, Das AK, Bush JT, Lejeune C, Schofield CJ, Basak A. 1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture. Chemical Communications (Cambridge, England). 49: 1930-2. PMID 23364467 DOI: 10.1039/C3Cc38251F |
0.643 |
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| 2013 |
Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International Ed. in English). 52: 1700-4. PMID 23296631 DOI: 10.1002/Anie.201208046 |
0.737 |
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| 2013 |
Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. Journal of Medicinal Chemistry. 56: 547-55. PMID 23234607 DOI: 10.1021/Jm301583M |
0.756 |
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| 2013 |
Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon EC, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Organic & Biomolecular Chemistry. 11: 732-45. PMID 23151668 DOI: 10.1039/C2Ob26648B |
0.802 |
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| 2013 |
Hamed RB, Gomez-Castellanos JR, Henry L, Ducho C, McDonough MA, Schofield CJ. The enzymes of β-lactam biosynthesis. Natural Product Reports. 30: 21-107. PMID 23135477 DOI: 10.1039/C2Np20065A |
0.71 |
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| 2013 |
Sánchez-Fernández EM, Tarhonskaya H, Al-Qahtani K, Hopkinson RJ, McCullagh JS, Schofield CJ, Flashman E. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. The Biochemical Journal. 449: 491-6. PMID 23092293 DOI: 10.1042/Bj20121155 |
0.323 |
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| 2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Schofield CJ, et al. 8-Hydroxyquinoline-5-Carboxylic Acid is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation Chemical Reviews. 4: 3110. DOI: 10.2210/Pdb4Bio/Pdb |
0.729 |
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| 2013 |
Bush JT, Walport LJ, McGouran JF, Leung IKH, Berridge G, Van Berkel SS, Basak A, Kessler BM, Schofield CJ. The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes Chemical Science. 4: 4115-4120. DOI: 10.1039/C3Sc51708J |
0.521 |
|
| 2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Schofield CJ, et al. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation Chemical Science. 4: 3110-3117. DOI: 10.1039/c3sc51122g |
0.781 |
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| 2013 |
Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ. Cover Picture: Chromophore-Linked Substrate (CLS405): Probing Metallo-β-Lactamase Activity and Inhibition (ChemMedChem 12/2013) Chemmedchem. 8: 1897-1897. DOI: 10.1002/Cmdc.201390050 |
0.578 |
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| 2012 |
Aik W, McDonough MA, Thalhammer A, Chowdhury R, Schofield CJ. Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Current Opinion in Structural Biology. 22: 691-700. PMID 23142576 DOI: 10.1016/J.Sbi.2012.10.001 |
0.701 |
|
| 2012 |
Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, ... ... Schofield CJ, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/Nchembio.1093 |
0.798 |
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| 2012 |
Walport LJ, Hopkinson RJ, Schofield CJ. Mechanisms of human histone and nucleic acid demethylases. Current Opinion in Chemical Biology. 16: 525-34. PMID 23063108 DOI: 10.1016/J.Cbpa.2012.09.015 |
0.34 |
|
| 2012 |
Hewings DS, Rooney TP, Jennings LE, Hay DA, Schofield CJ, Brennan PE, Knapp S, Conway SJ. Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. Journal of Medicinal Chemistry. 55: 9393-413. PMID 22924434 DOI: 10.1021/Jm300915B |
0.339 |
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| 2012 |
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, ... ... Schofield CJ, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 488: 404-8. PMID 22842901 DOI: 10.1038/Nature11262 |
0.408 |
|
| 2012 |
Henry L, Leung IK, Claridge TD, Schofield CJ. γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement. Bioorganic & Medicinal Chemistry Letters. 22: 4975-8. PMID 22765904 DOI: 10.1016/J.Bmcl.2012.06.024 |
0.339 |
|
| 2012 |
Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, ... ... Schofield CJ, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/Jm300677J |
0.803 |
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| 2012 |
Demetriades M, Leung IK, Chowdhury R, Chan MC, McDonough MA, Yeoh KK, Tian YM, Claridge TD, Ratcliffe PJ, Woon EC, Schofield CJ. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angewandte Chemie (International Ed. in English). 51: 6672-5. PMID 22639232 DOI: 10.1002/Anie.201202000 |
0.79 |
|
| 2012 |
Krylova SM, Koshkin V, Bagg E, Schofield CJ, Krylov SN. Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases. Journal of Medicinal Chemistry. 55: 3546-52. PMID 22471443 DOI: 10.1021/Jm300243H |
0.377 |
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| 2012 |
Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. Journal of Medicinal Chemistry. 55: 2173-84. PMID 22263962 DOI: 10.1021/Jm201417E |
0.771 |
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| 2012 |
Mantri M, Zhang Z, McDonough MA, Schofield CJ. Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases. The Febs Journal. 279: 1563-75. PMID 22251775 DOI: 10.1111/J.1742-4658.2012.08496.X |
0.566 |
|
| 2012 |
Chalker JM, Lercher L, Rose NR, Schofield CJ, Davis BG. Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angewandte Chemie (International Ed. in English). 51: 1835-9. PMID 22247073 DOI: 10.1002/Anie.201106432 |
0.54 |
|
| 2012 |
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International Ed. in English). 51: 1631-4. PMID 22241642 DOI: 10.1002/Anie.201107833 |
0.801 |
|
| 2012 |
Hamed RB, Henry L, Gomez-Castellanos JR, Mecinović J, Ducho C, Sorensen JL, Claridge TD, Schofield CJ. Crotonase catalysis enables flexible production of functionalized prolines and carbapenams. Journal of the American Chemical Society. 134: 471-9. PMID 22091817 DOI: 10.1021/Ja208318D |
0.699 |
|
| 2012 |
Inglis SR, Strieker M, Rydzik AM, Dessen A, Schofield CJ. A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases. Analytical Biochemistry. 420: 41-7. PMID 21925482 DOI: 10.1016/J.Ab.2011.08.036 |
0.344 |
|
| 2012 |
Mantri M, Webby CJ, Loik ND, Hamed RB, Nielsen ML, McDonough MA, McCullagh JSO, Böttger A, Schofield CJ, Wolf A. Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6 Medchemcomm. 3: 80-85. DOI: 10.1039/C1Md00225B |
0.737 |
|
| 2012 |
Thalhammer A, Aik W, Bagg EAL, Schofield CJ. The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets Drug Discovery Today: Therapeutic Strategies. 9: e91-e100. DOI: 10.1016/J.Ddstr.2012.02.002 |
0.342 |
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| 2011 |
Woon EC, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CW, Gobec S, Charlier P, Luxen A, Schofield CJ. Structure guided development of potent reversibly binding penicillin binding protein inhibitors. Acs Medicinal Chemistry Letters. 2: 219-23. PMID 24900305 DOI: 10.1021/Ml100260X |
0.72 |
|
| 2011 |
Mantri M, Loik ND, Hamed RB, Claridge TD, McCullagh JS, Schofield CJ. The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues. Chembiochem : a European Journal of Chemical Biology. 12: 531-4. PMID 22238144 DOI: 10.1002/Cbic.201000641 |
0.615 |
|
| 2011 |
Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. The Journal of Biological Chemistry. 286: 41616-25. PMID 21914792 DOI: 10.1074/Jbc.M111.283689 |
0.806 |
|
| 2011 |
Kawamura A, Loenarz C, Schofield CJ. Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry. Cell Cycle (Georgetown, Tex.). 10: 2819-20. PMID 21857150 DOI: 10.4161/Cc.10.17.16745 |
0.721 |
|
| 2011 |
Iqbal A, Clifton IJ, Chowdhury R, Ivison D, Domene C, Schofield CJ. Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates. Organic & Biomolecular Chemistry. 9: 6219-25. PMID 21796301 DOI: 10.1039/C1Ob05554B |
0.707 |
|
| 2011 |
Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A. Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA). Acs Chemical Biology. 6: 943-51. PMID 21732689 DOI: 10.1021/Cb2001846 |
0.716 |
|
| 2011 |
Rotili D, Altun M, Kawamura A, Wolf A, Fischer R, Leung IK, Mackeen MM, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. Chemistry & Biology. 18: 642-54. PMID 21609845 DOI: 10.1016/J.Chembiol.2011.03.007 |
0.777 |
|
| 2011 |
Chowdhury R, Flashman E, Mecinović J, Kramer HB, Kessler BM, Frapart YM, Boucher JL, Clifton IJ, McDonough MA, Schofield CJ. Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). Journal of Molecular Biology. 410: 268-79. PMID 21601578 DOI: 10.1016/J.Jmb.2011.04.075 |
0.747 |
|
| 2011 |
Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochemical and Biophysical Research Communications. 408: 553-8. PMID 21530488 DOI: 10.1016/J.Bbrc.2011.04.059 |
0.582 |
|
| 2011 |
Hamed RB, Gomez-Castellanos JR, Thalhammer A, Harding D, Ducho C, Claridge TD, Schofield CJ. Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases. Nature Chemistry. 3: 365-71. PMID 21505494 DOI: 10.1038/Nchem.1011 |
0.594 |
|
| 2011 |
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, ... ... Schofield CJ, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43 |
0.786 |
|
| 2011 |
Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. Chemmedchem. 6: 759-64. PMID 21412984 DOI: 10.1002/Cmdc.201100026 |
0.814 |
|
| 2011 |
Krylova SM, Karkhanina AA, Musheev MU, Bagg EA, Schofield CJ, Krylov SN. DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes. Analytical Biochemistry. 414: 261-5. PMID 21402046 DOI: 10.1016/J.Ab.2011.03.010 |
0.341 |
|
| 2011 |
Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Inhibition of 2-oxoglutarate dependent oxygenases. Chemical Society Reviews. 40: 4364-97. PMID 21390379 DOI: 10.1039/C0Cs00203H |
0.788 |
|
| 2011 |
Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ, Ratcliffe PJ. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. The Journal of Biological Chemistry. 286: 13041-51. PMID 21335549 DOI: 10.1074/Jbc.M110.211110 |
0.417 |
|
| 2011 |
Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). Plos One. 6: e16210. PMID 21264265 DOI: 10.1371/Journal.Pone.0016210 |
0.728 |
|
| 2011 |
Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The Febs Journal. 278: 1086-97. PMID 21251231 DOI: 10.1111/J.1742-4658.2011.08022.X |
0.766 |
|
| 2011 |
Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 286: 7648-60. PMID 21177872 DOI: 10.1074/Jbc.M110.193540 |
0.707 |
|
| 2011 |
Rotili D, Altun M, Hamed RB, Loenarz C, Thalhammer A, Hopkinson RJ, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. Chemical Communications (Cambridge, England). 47: 1488-90. PMID 21152646 DOI: 10.1039/C0Cc04457A |
0.772 |
|
| 2011 |
Loenarz C, Coleman ML, Boleininger A, Schierwater B, Holland PW, Ratcliffe PJ, Schofield CJ. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. Embo Reports. 12: 63-70. PMID 21109780 DOI: 10.1038/Embor.2010.170 |
0.697 |
|
| 2011 |
Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. Organic & Biomolecular Chemistry. 9: 127-35. PMID 21076780 DOI: 10.1039/C0Ob00592D |
0.783 |
|
| 2011 |
Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocrine-Related Cancer. 18: 73-83. PMID 20959442 DOI: 10.1677/Erc-10-0113 |
0.641 |
|
| 2011 |
Loenarz C, Schofield CJ. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends in Biochemical Sciences. 36: 7-18. PMID 20728359 DOI: 10.1016/J.Tibs.2010.07.002 |
0.744 |
|
| 2011 |
Leung IKH, Brown T, Schofield CJ, Claridge TDW. An approach to enzyme inhibition employing reversible boronate ester formation Medchemcomm. 2: 390-395. DOI: 10.1039/C1Md00011J |
0.367 |
|
| 2010 |
Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ. Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chemistry & Biology. 17: 1316-24. PMID 21168767 DOI: 10.1016/J.Chembiol.2010.09.016 |
0.6 |
|
| 2010 |
King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, ... Schofield CJ, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. Plos One. 5: e15535. PMID 21124847 DOI: 10.1371/Journal.Pone.0015535 |
0.761 |
|
| 2010 |
Sekirnik R, Rose NR, Mecinović J, Schofield CJ. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals. Metallomics : Integrated Biometal Science. 2: 397-9. PMID 21072385 DOI: 10.1039/C004952B |
0.566 |
|
| 2010 |
Hahn P, Wegener I, Burrells A, Böse J, Wolf A, Erck C, Butler D, Schofield CJ, Böttger A, Lengeling A. Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. Plos One. 5: e13769. PMID 21060799 DOI: 10.1371/Journal.Pone.0013769 |
0.539 |
|
| 2010 |
Schmierer B, Novák B, Schofield CJ. Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model. Bmc Systems Biology. 4: 139. PMID 20955552 DOI: 10.1186/1752-0509-4-139 |
0.359 |
|
| 2010 |
McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Current Opinion in Structural Biology. 20: 659-72. PMID 20888218 DOI: 10.1016/J.Sbi.2010.08.006 |
0.809 |
|
| 2010 |
Flashman E, Hoffart LM, Hamed RB, Bollinger JM, Krebs C, Schofield CJ. Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. The Febs Journal. 277: 4089-99. PMID 20840591 DOI: 10.1111/J.1742-4658.2010.07804.X |
0.62 |
|
| 2010 |
Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorganic & Medicinal Chemistry Letters. 20: 6125-8. PMID 20822901 DOI: 10.1016/J.Bmcl.2010.08.032 |
0.804 |
|
| 2010 |
Illingworth CJ, Loenarz C, Schofield CJ, Domene C. Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha. Biochemistry. 49: 6936-44. PMID 20695530 DOI: 10.1021/Bi100358T |
0.7 |
|
| 2010 |
Mantri M, Krojer T, Bagg EA, Webby CA, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. Journal of Molecular Biology. PMID 20685276 DOI: 10.1016/J.Jmb.2010.05.054 |
0.584 |
|
| 2010 |
Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. Journal of Molecular Biology. 401: 211-22. PMID 20684070 |
0.53 |
|
| 2010 |
Brown T, Charlier P, Herman R, Schofield CJ, Sauvage E. Structural basis for the interaction of lactivicins with serine beta-lactamases. Journal of Medicinal Chemistry. 53: 5890-4. PMID 20593835 DOI: 10.1021/Jm100437U |
0.3 |
|
| 2010 |
Mackeen MM, Kramer HB, Chang KH, Coleman ML, Hopkinson RJ, Schofield CJ, Kessler BM. Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. Journal of Proteome Research. 9: 4082-92. PMID 20583823 DOI: 10.1021/Pr100269B |
0.689 |
|
| 2010 |
Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C. Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Analytical Biochemistry. 404: 86-93. PMID 20435012 DOI: 10.1016/J.Ab.2010.04.030 |
0.754 |
|
| 2010 |
Hamed RB, Mecinović J, Ducho C, Claridge TD, Schofield CJ. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. Chemical Communications (Cambridge, England). 46: 1413-5. PMID 20162132 DOI: 10.1039/B924519G |
0.603 |
|
| 2010 |
Hopkinson RJ, Hamed RB, Rose NR, Claridge TD, Schofield CJ. Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde. Chembiochem : a European Journal of Chemical Biology. 11: 506-10. PMID 20095001 DOI: 10.1002/Cbic.200900713 |
0.687 |
|
| 2010 |
Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A. A miniaturized screen for inhibitors of Jumonji histone demethylases. Molecular Biosystems. 6: 357-64. PMID 20094655 DOI: 10.1039/B912993F |
0.56 |
|
| 2010 |
Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Journal of Medicinal Chemistry. 53: 1810-8. PMID 20088513 DOI: 10.1021/Jm901680B |
0.814 |
|
| 2010 |
Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. Febs Letters. 584: 825-30. PMID 20067792 DOI: 10.1016/J.Febslet.2009.12.055 |
0.773 |
|
| 2010 |
Flashman E, Davies SL, Yeoh KK, Schofield CJ. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. The Biochemical Journal. 427: 135-42. PMID 20055761 DOI: 10.1042/Bj20091609 |
0.401 |
|
| 2010 |
Leung IK, Flashman E, Yeoh KK, Schofield CJ, Claridge TD. Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. Journal of Medicinal Chemistry. 53: 867-75. PMID 20025281 DOI: 10.1021/Jm901537Q |
0.354 |
|
| 2010 |
Inglis SR, Woon EC, Thompson AL, Schofield CJ. Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates. The Journal of Organic Chemistry. 75: 468-71. PMID 20014787 DOI: 10.1021/Jo901930V |
0.683 |
|
| 2010 |
Iqbal A, Arunlanantham H, Brown T, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins. 78: 1398-407. PMID 20014241 DOI: 10.1002/Prot.22653 |
0.77 |
|
| 2010 |
Mackenzie AK, Valegård K, Iqbal A, Caines ME, Kershaw NJ, Jensen SE, Schofield CJ, Andersson I. Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid. Journal of Molecular Biology. 396: 332-44. PMID 19941870 DOI: 10.1016/J.Jmb.2009.11.045 |
0.329 |
|
| 2010 |
Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Human Molecular Genetics. 19: 217-22. PMID 19843542 DOI: 10.1093/Hmg/Ddp480 |
0.77 |
|
| 2010 |
Nagel S, Talbot NP, Mecinović J, Smith TG, Buchan AM, Schofield CJ. Therapeutic manipulation of the HIF hydroxylases. Antioxidants & Redox Signaling. 12: 481-501. PMID 19754349 DOI: 10.1089/Ars.2009.2711 |
0.342 |
|
| 2010 |
Kelly DJ, Mecinovic J, Arnold N, Suvarna K, Schofield CJ, Gunn J, Gershlick AH. 104 Upregulation of hypoxia-inducible factor 1α by di-methyl oxalyl glycine promotes angiogenesis within ischaemic myocardium in a porcine coronary occlusion model Heart. 96: A61.2-A62. DOI: 10.1136/Hrt.2010.196071.26 |
0.581 |
|
| 2010 |
Kelly DJ, Mecinovic J, Arnold N, Suvarna K, Schofield CJ, Gunn J, Gershlick AH. UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL Journal of the American College of Cardiology. 55: A216.E2047. DOI: 10.1016/S0735-1097(10)62048-7 |
0.601 |
|
| 2010 |
FEKNER T, BALDWIN JE, ADLINGTON RM, SCHOFIELD CJ. ChemInform Abstract: Unusually Stable Azetidinone Sulfenic Acids. Cheminform. 29: no-no. DOI: 10.1002/chin.199850126 |
0.314 |
|
| 2010 |
WESTWOOD NJ, SCHOFIELD CJ, CLARIDGE TDW. ChemInform Abstract: Studies on the Reactivity of Azetidin-2-ones in Phosphate Buffer. Cheminform. 29: no-no. DOI: 10.1002/chin.199802245 |
0.475 |
|
| 2010 |
ADLINGTON RM, BALDWIN JE, MCCOULL W, PRITCHARD GJ, SCHOFIELD CJ, WESTWOOD NJ. ChemInform Abstract: An Investigation of the N-Arylsulfonylation of 2-Azetidinones. Cheminform. 28: no-no. DOI: 10.1002/chin.199752129 |
0.535 |
|
| 2010 |
WALTER MW, ADLINGTON RM, BALDWIN JE, SCHOFIELD CJ. ChemInform Abstract: Synthesis of Metallo-β-lactamase Inhibitors. Cheminform. 28: no-no. DOI: 10.1002/chin.199742231 |
0.369 |
|
| 2010 |
THIRKETTLE JE, BALDWIN JE, EDWARDS J, GRIFFIN JP, SCHOFIELD CJ. ChemInform Abstract: The Origin of the β-Lactam Carbons of Clavulanic Acid. Cheminform. 28: no-no. DOI: 10.1002/chin.199741293 |
0.324 |
|
| 2010 |
BALDWIN JE, ADLINGTON RM, BRYANS JS, LLOYD MD, SEWELL TJ, SCHOFIELD CJ, BAGGALEY KH, CASSELS R. ChemInform Abstract: Chemoenzymatic Synthesis of Bicyclic γ-Lactams Using Clavaminic Acid Synthase. Cheminform. 28: no-no. DOI: 10.1002/chin.199739289 |
0.346 |
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| 2010 |
WALTER MW, FELICI A, GALLENI M, SOTO RP, ADLINGTON RM, BALDWIN JE, FRERE J, GOLOLOBOV M, SCHOFIELD CJ. ChemInform Abstract: Trifluoromethyl Alcohol and Ketone Inhibitors of Metallo-β- lactamases. Cheminform. 28: no-no. DOI: 10.1002/chin.199714159 |
0.539 |
|
| 2010 |
FEKNER T, BALDWIN JE, ADLINGTON RM, SCHOFIELD CJ. ChemInform Abstract: Syntheses of (6S,7S)- and (6S,7R)-Deacetoxycephalosporanic Acids from 6-Aminopenicillanic Acid. Cheminform. 27: no-no. DOI: 10.1002/chin.199648262 |
0.302 |
|
| 2010 |
FARTHING CN, BALDWIN JE, RUSSELL AT, SCHOFIELD CJ, SPIVEY AC. ChemInform Abstract: Syntheses of (S)-β-Pyrazolylalanine and (S)-Quisqualic Acid from a Serine-Derived Aziridine. Cheminform. 27: no-no. DOI: 10.1002/chin.199642222 |
0.588 |
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| 2010 |
BALDWIN JE, FARTHING CN, RUSSELL AT, SCHOFIELD CJ, SPIVEY AC. ChemInform Abstract: Use of (S)-N-tert-Butoxycarbonylaziridine-2-carboxylate Derivatives for α-Amino Acid Synthesis. Cheminform. 27: no-no. DOI: 10.1002/chin.199639222 |
0.599 |
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| 2010 |
WALTER MW, ADLINGTON RM, BALDWIN JE, CHUHAN J, SCHOFIELD CJ. ChemInform Abstract: Reaction of Ruppert′s Reagent (TMS-CF3) with Oxazolidinones: Synthesis of Protected α-Amino Trifluoromethylketones. Cheminform. 27: no-no. DOI: 10.1002/chin.199605231 |
0.325 |
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| 2010 |
LAWLOR EJ, ELSON SW, HOLLAND S, CASSELS R, HODGSON JE, LLOYD MD, BALDWIN JE, SCHOFIELD CJ. ChemInform Abstract: Expression in Escherichia coli of a Clavaminic Acid Synthase Isozyme: A Trifunctional Oxygenase Involved in Clavulanic Acid Biosynthesis. Cheminform. 25: no-no. DOI: 10.1002/chin.199449054 |
0.328 |
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| 2010 |
BALDWIN JE, FIELD RA, LAWRENCE CC, LEE V, ROBINSON JK, SCHOFIELD CJ. ChemInform Abstract: Substrate Specificity of Proline 4-Hydroxylase: Chemical and Enzymatic Synthesis of (2S,3R,4S)-Epoxyproline. Cheminform. 25: no-no. DOI: 10.1002/chin.199447216 |
0.509 |
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| 2010 |
BALDWIN JE, FUJISHIMA Y, GOH K, SCHOFIELD CJ. ChemInform Abstract: Enzymes of Valclavam Biosynthesis Cheminform. 25: no-no. DOI: 10.1002/chin.199434264 |
0.358 |
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| 2010 |
BALDWIN JE, SPIVEY AC, SCHOFIELD CJ, SWEENEY JB. ChemInform Abstract: Amino Acid Synthesis via Ring Opening of N-Sulfonyl Aziridine-2- carboxylate Esters with Organometallic Reagents. Cheminform. 24: no-no. DOI: 10.1002/chin.199346123 |
0.592 |
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| 2010 |
BALDWIN JE, HULME C, SCHOFIELD CJ, EDWARDS AJ. ChemInform Abstract: Synthesis of Potential β-Turn Bicyclic Dipeptide Mimetics. Cheminform. 24: no-no. DOI: 10.1002/chin.199336201 |
0.336 |
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| 2010 |
BALDWIN JE, LEE V, SCHOFIELD CJ. ChemInform Abstract: Synthesis of a Bicyclic γ-Lactam Dipeptide Analogue. Cheminform. 23: no-no. DOI: 10.1002/chin.199234157 |
0.329 |
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| 2010 |
BALDWIN JE, ADLINGTON RM, CROUCH NP, KEEPING JW, LEPPARD SW, PITLIK J, SCHOFIELD CJ, SOBEY WJ, WOOD ME. ChemInform Abstract: Studies on the Mechanism of Deacetoxy-Deacetylcephalosporin C Synthase Using Cyclopropyl Substituted Cephalosporin Probes. Cheminform. 23: no-no. DOI: 10.1002/chin.199210297 |
0.324 |
|
| 2010 |
BALDWIN JE, ADLINGTON RM, BRYANS JS, BRINGHEN AO, COATES JB, CROUCH NP, LLOYD MD, SCHOFIELD CJ, ELSON SW, BAGGALEY KH, CASSELS R, NICHOLSON N. ChemInform Abstract: Isolation of Dihydroclavaminic Acid (I), an Intermediate in the Biosynthesis of Clavulanic Acid Cheminform. 22: no-no. DOI: 10.1002/chin.199135272 |
0.313 |
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| 2010 |
BALDWIN JE, SPIVEY AC, SCHOFIELD CJ. ChemInform Abstract: Cyclic Sulfamidates: New Synthetic Precursors for β- Functionalized α-Amino Acids. Cheminform. 22: no-no. DOI: 10.1002/chin.199116260 |
0.593 |
|
| 2010 |
BALDWIN JE, LOWE C, SCHOFIELD CJ. ChemInform Abstract: The Synthesis of Potential γ-Lactam Antibiotics Containing a Cycloserine Nucleus. Cheminform. 22: no-no. DOI: 10.1002/chin.199111164 |
0.312 |
|
| 2009 |
Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinović J, Schofield CJ. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II). Chemical Communications (Cambridge, England). 6376-8. PMID 19841782 DOI: 10.1039/B916357C |
0.594 |
|
| 2009 |
Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorganic & Medicinal Chemistry Letters. 19: 6192-5. PMID 19775891 DOI: 10.1016/J.Bmcl.2009.09.005 |
0.774 |
|
| 2009 |
Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. Journal of Medicinal Chemistry. 52: 6097-106. PMID 19731939 DOI: 10.1021/Jm9009718 |
0.714 |
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| 2009 |
Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ. Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. Journal of Molecular Biology. 392: 994-1006. PMID 19646994 DOI: 10.1016/J.Jmb.2009.07.070 |
0.575 |
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| 2009 |
Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (London, England : 1993). 17: 981-9. PMID 19604478 DOI: 10.1016/J.Str.2009.06.002 |
0.812 |
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| 2009 |
Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg WD, Schofield CJ. Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. The Journal of Biological Chemistry. 284: 26831-8. PMID 19589782 DOI: 10.1074/Jbc.M109.009498 |
0.642 |
|
| 2009 |
Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, ... Schofield CJ, et al. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (New York, N.Y.). 325: 90-3. PMID 19574390 DOI: 10.1126/Science.1175865 |
0.525 |
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| 2009 |
Mecinović J, Chowdhury R, Flashman E, Schofield CJ. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. Analytical Biochemistry. 393: 215-21. PMID 19563769 DOI: 10.1016/J.Ab.2009.06.029 |
0.546 |
|
| 2009 |
Loenarz C, Schofield CJ. Oxygenase catalyzed 5-methylcytosine hydroxylation. Chemistry & Biology. 16: 580-3. PMID 19549596 DOI: 10.1016/J.Chembiol.2009.06.002 |
0.693 |
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| 2009 |
Ducho C, Hamed RB, Batchelar ET, Sorensen JL, Odell B, Schofield CJ. Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis. Organic & Biomolecular Chemistry. 7: 2770-9. PMID 19532994 DOI: 10.1039/B903312B |
0.695 |
|
| 2009 |
Karkhanina AA, Mecinović J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN. Direct analysis of enzyme-catalyzed DNA demethylation. Analytical Chemistry. 81: 5871-5. PMID 19518090 DOI: 10.1021/Ac9010556 |
0.32 |
|
| 2009 |
Caines ME, Sorensen JL, Schofield CJ. Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase. Biochemical and Biophysical Research Communications. 385: 512-7. PMID 19477162 DOI: 10.1016/J.Bbrc.2009.05.095 |
0.612 |
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| 2009 |
Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. Journal of Medicinal Chemistry. 52: 2799-805. PMID 19364117 DOI: 10.1021/Jm900285R |
0.702 |
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| 2009 |
Mecinović J, Hamed RB, Schofield CJ. Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water. Angewandte Chemie (International Ed. in English). 48: 2796-800. PMID 19280617 DOI: 10.1002/Anie.200806296 |
0.586 |
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| 2009 |
Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angewandte Chemie (International Ed. in English). 48: 1784-7. PMID 19180614 DOI: 10.1002/Anie.200805427 |
0.763 |
|
| 2009 |
Iqbal A, Clifton IJ, Bagonis M, Kershaw NJ, Domene C, Claridge TD, Wharton CW, Schofield CJ. Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase. Journal of the American Chemical Society. 131: 749-57. PMID 19105697 DOI: 10.1021/Ja807215U |
0.618 |
|
| 2009 |
Hamed RB, Batchelar ET, Mecinović J, Claridge TD, Schofield CJ. Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline. Chembiochem : a European Journal of Chemical Biology. 10: 246-50. PMID 19090510 DOI: 10.1002/Cbic.200800652 |
0.577 |
|
| 2009 |
Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Molecular Biosystems. 5: 52-8. PMID 19081931 DOI: 10.1039/B815271C |
0.56 |
|
| 2009 |
Thalhammer A, Mecinović J, Schofield CJ. Triflic anhydride-mediated synthesis of oxazoles Tetrahedron Letters. 50: 1045-1047. DOI: 10.1016/J.Tetlet.2008.12.080 |
0.63 |
|
| 2009 |
Hamed RB, Batchelar ET, Mecinović J, Claridge TDW, Schofield CJ. Cover Picture: Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline (ChemBioChem 2/2009) Chembiochem. 10: 189-189. DOI: 10.1002/Cbic.200990000 |
0.717 |
|
| 2008 |
Kaewpet M, Odell B, King MA, Banerji B, Schofield CJ, Claridge TD. Synthesis and conformational analysis of cyclic analogues of inverse gamma-turns. Organic & Biomolecular Chemistry. 6: 3476-85. PMID 19082148 DOI: 10.1039/B808954J |
0.702 |
|
| 2008 |
Lienard BM, Conejo-GarcÃa A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ. Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. Chemical Communications (Cambridge, England). 6393-5. PMID 19048166 DOI: 10.1039/B814440K |
0.701 |
|
| 2008 |
Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ. Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. Angewandte Chemie (International Ed. in English). 47: 9322-5. PMID 18972478 DOI: 10.1002/Anie.200803906 |
0.565 |
|
| 2008 |
Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. Journal of Medicinal Chemistry. 51: 7053-6. PMID 18942826 DOI: 10.1021/Jm800936S |
0.686 |
|
| 2008 |
Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. The Biochemical Journal. 416: 387-94. PMID 18713068 DOI: 10.1042/Bj20081238 |
0.758 |
|
| 2008 |
Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). The Journal of Biological Chemistry. 283: 25971-8. PMID 18611856 DOI: 10.1074/Jbc.M804999200 |
0.748 |
|
| 2008 |
Chowdhury R, Hardy A, Schofield CJ. The human oxygen sensing machinery and its manipulation. Chemical Society Reviews. 37: 1308-19. PMID 18568157 DOI: 10.1039/B701676J |
0.669 |
|
| 2008 |
Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Organic & Biomolecular Chemistry. 6: 2282-94. PMID 18563261 DOI: 10.1039/B802311E |
0.358 |
|
| 2008 |
Hamed RB, Batchelar ET, Clifton IJ, Schofield CJ. Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity. Cellular and Molecular Life Sciences : Cmls. 65: 2507-27. PMID 18470480 DOI: 10.1007/S00018-008-8082-6 |
0.725 |
|
| 2008 |
Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nature Chemical Biology. 4: 152-6. PMID 18277970 DOI: 10.1038/Nchembio0308-152 |
0.704 |
|
| 2008 |
Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. The Journal of Biological Chemistry. 283: 3808-15. PMID 18063574 DOI: 10.1074/Jbc.M707411200 |
0.81 |
|
| 2008 |
Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck MR, Oldham NJ, Schofield CJ. ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site. Chemmedchem. 3: 569-72. PMID 18058781 DOI: 10.1002/Cmdc.200700233 |
0.512 |
|
| 2008 |
Loenarz C, Chowdhury R, Schofield CJ, Flashman E. Oxygenases for oxygen sensing Pure and Applied Chemistry. 80: 1837-1847. DOI: 10.1351/Pac200880081837 |
0.771 |
|
| 2008 |
Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck M, Oldham N, Schofield C. Cover Picture: ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site (ChemMedChem 4/2008) Chemmedchem. 3: 509-509. DOI: 10.1002/Cmdc.200890014 |
0.689 |
|
| 2007 |
Hewitson KS, Schofield CJ, Ratcliffe PJ. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2. Methods in Enzymology. 435: 25-42. PMID 17998047 DOI: 10.1016/S0076-6879(07)35002-7 |
0.323 |
|
| 2007 |
Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, ... ... Schofield CJ, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (New York, N.Y.). 318: 1469-72. PMID 17991826 DOI: 10.1126/Science.1151710 |
0.528 |
|
| 2007 |
Schofield CJ, McDonough MA. Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH). Biochemical Society Transactions. 35: 870-5. PMID 17956235 DOI: 10.1042/Bst0350870 |
0.538 |
|
| 2007 |
Macheboeuf P, Fischer DS, Brown T, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nature Chemical Biology. 3: 565-9. PMID 17676039 DOI: 10.1038/Nchembio.2007.21 |
0.316 |
|
| 2007 |
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, ... Schofield CJ, et al. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 448: 87-91. PMID 17589501 DOI: 10.1038/Nature05971 |
0.689 |
|
| 2007 |
Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 282: 24027-38. PMID 17573339 DOI: 10.1074/Jbc.M704102200 |
0.733 |
|
| 2007 |
Borowski T, de Marothy S, Broclawik E, Schofield CJ, Siegbahn PE. Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies. Biochemistry. 46: 3682-91. PMID 17323933 DOI: 10.1021/Bi602458M |
0.311 |
|
| 2007 |
MacKenzie AK, Kershaw NJ, Hernandez H, Robinson CV, Schofield CJ, Andersson I. Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid. Biochemistry. 46: 1523-33. PMID 17279617 DOI: 10.1021/Bi061978X |
0.375 |
|
| 2007 |
Flashman E, Schofield CJ. The most versatile of all reactive intermediates? Nature Chemical Biology. 3: 86-7. PMID 17235343 DOI: 10.1038/Nchembio0207-86 |
0.316 |
|
| 2007 |
Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Inhibitors of the FEZ-1 metallo-beta-lactamase. Bioorganic & Medicinal Chemistry Letters. 17: 964-8. PMID 17157014 DOI: 10.1016/J.Bmcl.2006.11.053 |
0.309 |
|
| 2007 |
Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. The Journal of Biological Chemistry. 282: 3293-301. PMID 17135241 DOI: 10.1074/Jbc.M608337200 |
0.729 |
|
| 2007 |
Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. The Biochemical Journal. 401: 227-34. PMID 16952279 DOI: 10.1042/Bj20061151 |
0.324 |
|
| 2007 |
Shanley SJ, Schofield CJ, Coles SJ, Watkin DJ, Fischer DS. 4-Nitrobenzyl 5-oxo-2-(2-oxopiperidin-1-yl)tetrahydrofuran-2-carboxylate Acta Crystallographica Section E Structure Reports Online. 63: o1523-o1525. DOI: 10.1107/S1600536807008720 |
0.309 |
|
| 2006 |
Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proceedings of the National Academy of Sciences of the United States of America. 103: 14767-72. PMID 17003112 DOI: 10.1073/Pnas.0606877103 |
0.593 |
|
| 2006 |
Bassan A, Borowski T, Schofield CJ, Siegbahn PE. Ethylene biosynthesis by 1-aminocyclopropane-1-carboxylic acid oxidase: a DFT study. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 8835-46. PMID 16933342 DOI: 10.1002/Chem.200501459 |
0.319 |
|
| 2006 |
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, ... ... Schofield CJ, et al. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proceedings of the National Academy of Sciences of the United States of America. 103: 9814-9. PMID 16782814 DOI: 10.1073/Pnas.0601283103 |
0.77 |
|
| 2006 |
Liu B, Schofield CJ, Wilmouth RC. Structural analyses on intermediates in serine protease catalysis. The Journal of Biological Chemistry. 281: 24024-35. PMID 16754679 DOI: 10.1074/Jbc.M600495200 |
0.334 |
|
| 2006 |
Selevsek N, Tholey A, Heinzle E, Liénard BM, Oldham NJ, Schofield CJ, Heinz U, Adolph HW, Frère JM. Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry. Journal of the American Society For Mass Spectrometry. 17: 1000-4. PMID 16713713 DOI: 10.1016/J.Jasms.2006.03.010 |
0.36 |
|
| 2006 |
Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. Journal of Inorganic Biochemistry. 100: 644-69. PMID 16513174 DOI: 10.1016/J.Jinorgbio.2006.01.024 |
0.709 |
|
| 2006 |
Murray-Rust TA, Oldham NJ, Hewitson KS, Schofield CJ. Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro. Febs Letters. 580: 1911-8. PMID 16500650 DOI: 10.1016/J.Febslet.2006.02.012 |
0.328 |
|
| 2006 |
Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ. ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid. The Journal of Biological Chemistry. 281: 279-87. PMID 16251194 DOI: 10.1074/Jbc.M507711200 |
0.328 |
|
| 2006 |
Seibel J, Macdonald SJ, Schofield CJ. Synthesis of δ-Lactam (2-Oxopiperazine) Inhibitors of Elastase. Cheminform. 37. DOI: 10.3184/030823405775146951 |
0.632 |
|
| 2005 |
McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ. Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. Molecular Biosystems. 1: 321-4. PMID 16880998 DOI: 10.1039/B511249B |
0.602 |
|
| 2005 |
Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MR, Hewitson KS, Oldham NJ, Schofield CJ. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. Chemical Communications (Cambridge, England). 5438-40. PMID 16261239 DOI: 10.1039/B510707E |
0.757 |
|
| 2005 |
McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. The Journal of Biological Chemistry. 280: 41101-10. PMID 16186124 DOI: 10.1074/Jbc.M507528200 |
0.562 |
|
| 2005 |
Welford RW, Kirkpatrick JM, McNeill LA, Puri M, Oldham NJ, Schofield CJ. Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans. Febs Letters. 579: 5170-4. PMID 16153644 DOI: 10.1016/J.Febslet.2005.08.033 |
0.335 |
|
| 2005 |
Schofield CJ, Ratcliffe PJ. Signalling hypoxia by HIF hydroxylases. Biochemical and Biophysical Research Communications. 338: 617-26. PMID 16139242 DOI: 10.1016/J.Bbrc.2005.08.111 |
0.341 |
|
| 2005 |
Kershaw NJ, Caines ME, Sleeman MC, Schofield CJ. The enzymology of clavam and carbapenem biosynthesis. Chemical Communications (Cambridge, England). 4251-63. PMID 16113715 DOI: 10.1039/B505964J |
0.306 |
|
| 2005 |
Welford RW, Clifton IJ, Turnbull JJ, Wilson SC, Schofield CJ. Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism. Organic & Biomolecular Chemistry. 3: 3117-26. PMID 16106293 DOI: 10.1039/B507153D |
0.602 |
|
| 2005 |
Sleeman MC, Sorensen JL, Batchelar ET, McDonough MA, Schofield CJ. Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis. The Journal of Biological Chemistry. 280: 34956-65. PMID 16096274 DOI: 10.1074/Jbc.M507196200 |
0.704 |
|
| 2005 |
Searls T, Butler D, Chien W, Mukherji M, Lloyd MD, Schofield CJ. Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands. Journal of Lipid Research. 46: 1660-7. PMID 15930519 DOI: 10.1194/Jlr.M500034-Jlr200 |
0.367 |
|
| 2005 |
McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. Selective inhibition of factor inhibiting hypoxia-inducible factor. Journal of the American Chemical Society. 127: 7680-1. PMID 15913349 DOI: 10.1021/Ja050841B |
0.787 |
|
| 2005 |
Hewitson KS, Granatino N, Welford RW, McDonough MA, Schofield CJ. Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 363: 807-28; discussion 1. PMID 15901537 DOI: 10.1098/Rsta.2004.1540 |
0.582 |
|
| 2005 |
Long AJ, Clifton IJ, Roach PL, Baldwin JE, Rutledge PJ, Schofield CJ. Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine. Biochemistry. 44: 6619-28. PMID 15850395 DOI: 10.1021/Bi047478Q |
0.756 |
|
| 2005 |
Sorensen JL, Sleeman MC, Schofield CJ. Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. Chemical Communications (Cambridge, England). 1155-7. PMID 15726176 DOI: 10.1039/B416423G |
0.539 |
|
| 2005 |
Flashman E, McDonough MA, Schofield CJ. OS-9: another piece in the HIF complex story. Molecular Cell. 17: 472-3. PMID 15721249 DOI: 10.1016/J.Molcel.2005.02.001 |
0.532 |
|
| 2005 |
McNeill LA, Bethge L, Hewitson KS, Schofield CJ. A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases. Analytical Biochemistry. 336: 125-31. PMID 15582567 DOI: 10.1016/J.Ab.2004.09.019 |
0.312 |
|
| 2005 |
Elkins JM, Kershaw NJ, Schofield CJ. X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster. The Biochemical Journal. 385: 565-73. PMID 15352873 DOI: 10.1042/Bj20040814 |
0.668 |
|
| 2004 |
Lancaster DE, McDonough MA, Schofield CJ. Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. Biochemical Society Transactions. 32: 943-5. PMID 15506931 DOI: 10.1042/Bst0320943 |
0.556 |
|
| 2004 |
Zhang Z, Ren JS, Clifton IJ, Schofield CJ. Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme. Chemistry & Biology. 11: 1383-94. PMID 15489165 DOI: 10.1016/J.Chembiol.2004.08.012 |
0.622 |
|
| 2004 |
Hewitson KS, Schofield CJ. The HIF pathway as a therapeutic target. Drug Discovery Today. 9: 704-11. PMID 15341784 DOI: 10.1016/S1359-6446(04)03202-7 |
0.313 |
|
| 2004 |
Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. The Biochemical Journal. 383: 429-37. PMID 15239670 DOI: 10.1042/Bj20040735 |
0.596 |
|
| 2004 |
Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nature Reviews. Molecular Cell Biology. 5: 343-54. PMID 15122348 DOI: 10.1038/Nrm1366 |
0.329 |
|
| 2004 |
Hewitson KS, McNeill LA, Schofield CJ. Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer. Current Pharmaceutical Design. 10: 821-33. PMID 15032687 DOI: 10.2174/1381612043452884 |
0.333 |
|
| 2004 |
Lloyd MD, Lipscomb SJ, Hewitson KS, Hensgens CM, Baldwin JE, Schofield CJ. Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase. The Journal of Biological Chemistry. 279: 15420-6. PMID 14734549 DOI: 10.1074/Jbc.M313928200 |
0.484 |
|
| 2004 |
Sleeman MC, Schofield CJ. Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. The Journal of Biological Chemistry. 279: 6730-6. PMID 14625287 DOI: 10.1074/Jbc.M311824200 |
0.333 |
|
| 2003 |
Caines ME, Elkins JM, Hewitson KS, Schofield CJ. Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway. The Journal of Biological Chemistry. 279: 5685-92. PMID 14623876 DOI: 10.1074/Jbc.M310803200 |
0.683 |
|
| 2003 |
McDonough MA, Schofield CJ. New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria. Chemistry & Biology. 10: 898-900. PMID 14583255 DOI: 10.1016/J.Chembiol.2003.10.002 |
0.573 |
|
| 2003 |
Turnbull JJ, Nakajima J, Welford RW, Yamazaki M, Saito K, Schofield CJ. Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase. The Journal of Biological Chemistry. 279: 1206-16. PMID 14570878 DOI: 10.1074/Jbc.M309228200 |
0.314 |
|
| 2003 |
Turnbull JJ, Nagle MJ, Seibel JF, Welford RW, Grant GH, Schofield CJ. The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. Bioorganic & Medicinal Chemistry Letters. 13: 3853-7. PMID 14552794 DOI: 10.1016/S0960-894X(03)00711-X |
0.621 |
|
| 2003 |
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. Bioorganic & Medicinal Chemistry Letters. 13: 2677-80. PMID 12873492 DOI: 10.1016/S0960-894X(03)00539-0 |
0.341 |
|
| 2003 |
Hewitson KS, McNeill LA, Elkins JM, Schofield CJ. The role of iron and 2-oxoglutarate oxygenases in signalling. Biochemical Society Transactions. 31: 510-5. PMID 12773146 DOI: 10.1042/Bst0310510 |
0.675 |
|
| 2003 |
Damblon C, Jensen M, Ababou A, Barsukov I, Papamicael C, Schofield CJ, Olsen L, Bauer R, Roberts GC. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. The Journal of Biological Chemistry. 278: 29240-51. PMID 12724330 DOI: 10.1074/Jbc.M301562200 |
0.354 |
|
| 2003 |
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases. Bioorganic & Medicinal Chemistry Letters. 13: 1451-4. PMID 12668010 DOI: 10.1016/S0960-894X(03)00149-5 |
0.359 |
|
| 2003 |
Lee HJ, Dai YF, Shiau CY, Schofield CJ, Lloyd MD. The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase. European Journal of Biochemistry. 270: 1301-7. PMID 12631288 DOI: 10.1046/J.1432-1033.2003.03500.X |
0.332 |
|
| 2003 |
Long AJ, Clifton IJ, Roach PL, Baldwin JE, Schofield CJ, Rutledge PJ. Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate. The Biochemical Journal. 372: 687-93. PMID 12622704 DOI: 10.1042/Bj20021627 |
0.751 |
|
| 2003 |
Clifton IJ, Doan LX, Sleeman MC, Topf M, Suzuki H, Wilmouth RC, Schofield CJ. Crystal structure of carbapenem synthase (CarC). The Journal of Biological Chemistry. 278: 20843-50. PMID 12611886 DOI: 10.1074/Jbc.M213054200 |
0.611 |
|
| 2003 |
Seibel J, Brown D, Amour A, Macdonald SJ, Oldham NJ, Schofield CJ. Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 387-9. PMID 12565935 DOI: 10.1016/S0960-894X(02)00995-2 |
0.628 |
|
| 2003 |
Welford RW, Schlemminger I, McNeill LA, Hewitson KS, Schofield CJ. The selectivity and inhibition of AlkB. The Journal of Biological Chemistry. 278: 10157-61. PMID 12517755 DOI: 10.1074/Jbc.M211058200 |
0.374 |
|
| 2003 |
Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. The Journal of Biological Chemistry. 278: 1802-6. PMID 12446723 DOI: 10.1074/Jbc.C200644200 |
0.773 |
|
| 2002 |
McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. The Biochemical Journal. 367: 571-5. PMID 12215170 DOI: 10.1042/Bj20021162 |
0.625 |
|
| 2002 |
Antony J, Gresh N, Olsen L, Hemmingsen L, Schofield CJ, Bauer R. Binding of D- and L-captopril inhibitors to metallo-beta-lactamase studied by polarizable molecular mechanics and quantum mechanics. Journal of Computational Chemistry. 23: 1281-96. PMID 12210153 DOI: 10.1002/Jcc.10111 |
0.339 |
|
| 2002 |
Migaud ME, Wilmouth RC, Mills GI, Wayne GJ, Risley C, Chambers C, Macdonald SJ, Schofield CJ. 5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. Chemical Communications (Cambridge, England). 1274-5. PMID 12109112 DOI: 10.1039/B111627D |
0.336 |
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| 2002 |
Zhang Z, Ren Js, Harlos K, McKinnon CH, Clifton IJ, Schofield CJ. Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements. Febs Letters. 517: 7-12. PMID 12062399 DOI: 10.1016/S0014-5793(02)02520-6 |
0.589 |
|
| 2002 |
Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature. 417: 975-8. PMID 12050673 DOI: 10.1038/Nature00767 |
0.308 |
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| 2002 |
Lipscomb SJ, Lee HJ, Mukherji M, Baldwin JE, Schofield CJ, Lloyd MD. The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase. European Journal of Biochemistry / Febs. 269: 2735-9. PMID 12047382 DOI: 10.1046/J.1432-1033.2002.02945.X |
0.482 |
|
| 2002 |
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. The Journal of Biological Chemistry. 277: 26351-5. PMID 12042299 DOI: 10.1074/Jbc.C200273200 |
0.673 |
|
| 2002 |
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorganic & Medicinal Chemistry Letters. 12: 1547-50. PMID 12039559 DOI: 10.1016/S0960-894X(02)00219-6 |
0.349 |
|
| 2002 |
Mukherji M, Kershaw NJ, Schofield CJ, Wierzbicki AS, Lloyd MD. Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid. Chemistry & Biology. 9: 597-605. PMID 12031666 DOI: 10.1016/S1074-5521(02)00139-4 |
0.321 |
|
| 2002 |
Elkins JM, Clifton IJ, Hernández H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS. Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. The Biochemical Journal. 366: 423-34. PMID 12020346 DOI: 10.1042/Bj20020125 |
0.762 |
|
| 2002 |
Kershaw NJ, McNaughton HJ, Hewitson KS, Hernández H, Griffin J, Hughes C, Greaves P, Barton B, Robinson CV, Schofield CJ. ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity. European Journal of Biochemistry / Febs. 269: 2052-9. PMID 11985581 DOI: 10.1046/J.1432-1033.2002.02853.X |
0.329 |
|
| 2002 |
Topf M, Várnai P, Schofield CJ, Richards WG. Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases. Proteins. 47: 357-69. PMID 11948789 DOI: 10.1002/Prot.10097 |
0.335 |
|
| 2002 |
Katona G, Wilmouth RC, Wright PA, Berglund GI, Hajdu J, Neutze R, Schofield CJ. X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution. The Journal of Biological Chemistry. 277: 21962-70. PMID 11896054 DOI: 10.1074/Jbc.M200676200 |
0.377 |
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| 2002 |
Sleeman MC, MacKinnon CH, Hewitson KS, Schofield CJ. Enzymatic synthesis of monocyclic beta-lactams. Bioorganic & Medicinal Chemistry Letters. 12: 597-9. PMID 11844680 DOI: 10.1016/S0960-894X(01)00806-X |
0.31 |
|
| 2002 |
Wilmouth RC, Turnbull JJ, Welford RW, Clifton IJ, Prescott AG, Schofield CJ. Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Structure (London, England : 1993). 10: 93-103. PMID 11796114 DOI: 10.1016/S0969-2126(01)00695-5 |
0.61 |
|
| 2002 |
Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J. Snapshots of serine protease catalysis: unravelling the mechanism of deacylation Acta Crystallographica Section a Foundations of Crystallography. 58: c27-c27. DOI: 10.1107/S010876730208618X |
0.578 |
|
| 2001 |
Clifton IJ, Hsueh LC, Baldwin JE, Harlos K, Schofield CJ. Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases. European Journal of Biochemistry / Febs. 268: 6625-36. PMID 11737217 DOI: 10.1046/J.0014-2956.2001.02617.X |
0.678 |
|
| 2001 |
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, ... ... Schofield CJ, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107: 43-54. PMID 11595184 DOI: 10.1016/S0092-8674(01)00507-4 |
0.375 |
|
| 2001 |
Mollard C, Moali C, Papamicael C, Damblon C, Vessilier S, Amicosante G, Schofield CJ, Galleni M, Frere JM, Roberts GC. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. The Journal of Biological Chemistry. 276: 45015-23. PMID 11564740 DOI: 10.1074/Jbc.M107054200 |
0.365 |
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| 2001 |
Mukherji M, Chien W, Kershaw NJ, Clifton IJ, Schofield CJ, Wierzbicki AS, Lloyd MD. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. Human Molecular Genetics. 10: 1971-82. PMID 11555634 DOI: 10.1093/Hmg/10.18.1971 |
0.596 |
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| 2001 |
Kershaw NJ, Mukherji M, MacKinnon CH, Claridge TD, Odell B, Wierzbicki AS, Lloyd MD, Schofield CJ. Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A. Bioorganic & Medicinal Chemistry Letters. 11: 2545-8. PMID 11549466 DOI: 10.1016/S0960-894X(01)00494-2 |
0.369 |
|
| 2001 |
Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J. X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate. Nature Structural Biology. 8: 689-94. PMID 11473259 DOI: 10.1038/90401 |
0.604 |
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| 2001 |
Dubus A, Lloyd MD, Lee HJ, Schofield CJ, Baldwin JE, Frere JM. Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase. Cellular and Molecular Life Sciences : Cmls. 58: 835-43. PMID 11437242 DOI: 10.1007/Pl00000904 |
0.488 |
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| 2001 |
Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ. Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein. European Journal of Biochemistry / Febs. 268: 2969-74. PMID 11358514 DOI: 10.1046/J.1432-1327.2001.02186.X |
0.598 |
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| 2001 |
Lee HJ, Lloyd MD, Harlos K, Clifton IJ, Baldwin JE, Schofield CJ. Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS). Journal of Molecular Biology. 308: 937-48. PMID 11352583 DOI: 10.1006/Jmbi.2001.4649 |
0.661 |
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| 2001 |
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (New York, N.Y.). 292: 468-72. PMID 11292861 DOI: 10.1126/Science.1059796 |
0.312 |
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| 2001 |
Lee HJ, Lloyd MD, Clifton IJ, Harlos K, Dubus A, Baldwin JE, Frere JM, Schofield CJ. Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258. The Journal of Biological Chemistry. 276: 18290-5. PMID 11279000 DOI: 10.1074/Jbc.M100085200 |
0.671 |
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| 2001 |
Mukherji M, Kershaw NJ, MacKinnon CH, Clifton IJ, Wierzbicki AS, Schofield CJ, Lloyd MD. ‘Chemical co-substrate rescue’ of phytanoyl-CoA 2-hydroxylase mutants causing Refsum’s Disease Chemical Communications. 2001: 972-973. DOI: 10.1039/B101039P |
0.315 |
|
| 2001 |
Beardsell M, Hinchliffe PS, Wood JM, Wilmouth RC, Schofield CJ, Page MI. β-Sultams—A novel class of serine protease inhibitors Chemical Communications. 497-498. DOI: 10.1039/B100294P |
0.343 |
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| 2000 |
Doan LX, Hassan A, Lipscomb SJ, Dhanda A, Zhang Z, Schofield CJ. Mutagenesis studies on the iron binding ligands of clavaminic acid synthase. Biochemical and Biophysical Research Communications. 279: 240-4. PMID 11112446 DOI: 10.1006/Bbrc.2000.3915 |
0.335 |
|
| 2000 |
Dubus A, Sami M, Brown TJ, Schofield CJ, Baldwin JE, Frère JM. Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay. Febs Letters. 485: 142-6. PMID 11094156 DOI: 10.1016/S0014-5793(00)02221-3 |
0.482 |
|
| 2000 |
Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ. 'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes. The Biochemical Journal. 351: 335-40. PMID 11023818 DOI: 10.1042/Bj3510335 |
0.612 |
|
| 2000 |
Wright PA, Rostom AA, Robinson CV, Schofield CJ. Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin. Bioorganic & Medicinal Chemistry Letters. 10: 1219-21. PMID 10866385 DOI: 10.1016/S0960-894X(00)00194-3 |
0.327 |
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| 2000 |
Zhang Z, Ren J, Stammers DK, Baldwin JE, Harlos K, Schofield CJ. Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nature Structural Biology. 7: 127-33. PMID 10655615 DOI: 10.1038/72398 |
0.47 |
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| 2000 |
Schofield CJ, Zhang Z. Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Current Opinion in Structural Biology. 9: 722-31. PMID 10607676 DOI: 10.1016/S0959-440X(99)00036-6 |
0.339 |
|
| 2000 |
Walter MW, Thaker N, Baldwin JE, Muller M, Schofield CJ. The reaction of TMS-CF3 with amino acid derived ring-templates: Studies with oxazin-2-ones and oxazolidin-5-ones Journal of Chemical Research - Part S. 310-311. DOI: 10.3184/030823400103167606 |
0.41 |
|
| 2000 |
Fekner T, Baldwin JE, Adlington RM, Jones TW, Prout C, Schofield CJ. Syntheses of (6S)-Cephalosporins from 6-Aminopenicillanic Acid Tetrahedron. 56: 6053-6074. DOI: 10.1016/S0040-4020(00)00486-5 |
0.561 |
|
| 2000 |
Wilmouth RC, Li Y, Wright PA, Claridge TD, Aplin RT, Schofield CJ. Reaction of Clavams with Elastase Reveals a General Method for Inhibiting ‘Serine’ Enzymes Tetrahedron. 56: 5729-5733. DOI: 10.1016/S0040-4020(00)00428-2 |
0.389 |
|
| 1999 |
Wilmouth RC, Kassamally S, Westwood NJ, Sheppard RJ, Claridge TD, Aplin RT, Wright PA, Pritchard GJ, Schofield CJ. Mechanistic insights into the inhibition of serine proteases by monocyclic lactams. Biochemistry. 38: 7989-98. PMID 10387042 DOI: 10.1021/Bi990098Y |
0.601 |
|
| 1999 |
Lloyd MD, Lee HJ, Harlos K, Zhang ZH, Baldwin JE, Schofield CJ, Charnock JM, Garner CD, Hara T, Terwisscha van Scheltinga AC, Valegård K, Viklund JA, Hajdu J, Andersson I, Danielsson A, et al. Studies on the active site of deacetoxycephalosporin C synthase. Journal of Molecular Biology. 287: 943-60. PMID 10222202 DOI: 10.1006/Jmbi.1999.2594 |
0.444 |
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| 1999 |
Lloyd MD, Lee H, Baldwin JE, Schofield CJ, Charnock JM, Garner CD. Studies on Deacetoxycephalosporin C Synthase Biochemical Society Transactions. 27: A36-A36. DOI: 10.1042/Bst027A036C |
0.389 |
|
| 1999 |
Simpson TJ, R. Hanson J, B. Herbert R, Robins DJ, Vederas JC, Schofield CJ, Mann J. Book Reviews: : Comprehensive Natural Products Chemistry. Volumes 1 to 8. Natural Product Reports. 16: 637. DOI: 10.1039/A905Bkry |
0.434 |
|
| 1999 |
Lloyd MD, Merritt KD, Lee V, Sewell TJ, Wha-Son B, Baldwin JE, Schofield CJ, Elson SW, Baggaley KH, Nicholson NH. Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase Tetrahedron. 55: 10201-10220. DOI: 10.1016/S0040-4020(99)00547-5 |
0.439 |
|
| 1999 |
Walter MW, Valladares MH, Adlington RM, Amicosante G, Baldwin JE, Frère JM, Galleni M, Rossolini GM, Schofield CJ. Hydroxamate inhibitors of Aeromonas hydrophila AE036 metallo-β- lactamase Bioorganic Chemistry. 27: 35-40. DOI: 10.1006/Bioo.1998.1111 |
0.634 |
|
| 1998 |
Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ. Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex. Biochemistry. 37: 17506-13. PMID 9860865 DOI: 10.1021/Bi9816249 |
0.702 |
|
| 1998 |
Valegård K, van Scheltinga AC, Lloyd MD, Hara T, Ramaswamy S, Perrakis A, Thompson A, Lee HJ, Baldwin JE, Schofield CJ, Hajdu J, Andersson I. Structure of a cephalosporin synthase. Nature. 394: 805-9. PMID 9723623 DOI: 10.1038/29575 |
0.487 |
|
| 1998 |
McNaughton HJ, Thirkettle JE, Zhang Z, Schofield CJ, Jensen SE, Barton B, Greaves P. β-Lactam synthetase: implications for β-lactamase evolution Chemical Communications. 2325-2326. DOI: 10.1039/A806713I |
0.317 |
|
| 1998 |
Walter MW, Adlington RM, Baldwin JE, Schofield CJ. Reaction of (Trifluoromethyl)trimethylsilane with Oxazolidin-5-ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones The Journal of Organic Chemistry. 63: 5179-5192. DOI: 10.1021/Jo980443+ |
0.614 |
|
| 1998 |
Fekner T, Baldwin JE, Adlington RM, Schofield CJ. Unusually stable azetidinone sulfenic acids Tetrahedron Letters. 39: 6983-6986. DOI: 10.1016/S0040-4039(98)01482-8 |
0.576 |
|
| 1998 |
Kenneth Robinson J, Lee V, Claridge TD, Baldwin JE, Schofield CJ. Synthesis of (2S, 3R, 4S), (2S, 3S, 4R)-epoxyprolines and aminohydroxyprolines Tetrahedron. 54: 981-996. DOI: 10.1016/S0040-4020(97)10352-0 |
0.394 |
|
| 1998 |
Gibson EJ, Zhang Z, Baldwin JE, Schofield CJ. Substrate analogues and inhibition of ACC oxidase: Conversion of D- valine to iso-butanal Phytochemistry. 48: 619-624. DOI: 10.1016/S0031-9422(97)00965-5 |
0.465 |
|
| 1997 |
Byford MF, Baldwin JE, Shiau CY, Schofield CJ. The Mechanism of ACV Synthetase. Chemical Reviews. 97: 2631-2650. PMID 11851475 DOI: 10.1021/Cr960018L |
0.374 |
|
| 1997 |
Schofield CJ, Baldwin JE, Byford MF, Clifton I, Hajdu J, Hensgens C, Roach P. Proteins of the penicillin biosynthesis pathway. Current Opinion in Structural Biology. 7: 857-64. PMID 9434907 DOI: 10.1016/S0959-440X(97)80158-3 |
0.663 |
|
| 1997 |
Zhang Z, Barlow JN, Baldwin JE, Schofield CJ. Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase. Biochemistry. 36: 15999-6007. PMID 9398335 DOI: 10.1021/Bi971823C |
0.489 |
|
| 1997 |
Shiau CY, Byford MF, Aplin RT, Baldwin JE, Schofield CJ. L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation. Biochemistry. 36: 8798-806. PMID 9220966 DOI: 10.1021/Bi962932E |
0.428 |
|
| 1997 |
Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature. 387: 827-30. PMID 9194566 DOI: 10.1038/42990 |
0.656 |
|
| 1997 |
Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ. Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase. Nature Structural Biology. 4: 456-62. PMID 9187653 DOI: 10.1038/Nsb0697-456 |
0.693 |
|
| 1997 |
Barlow JN, Zhang Z, John P, Baldwin JE, Schofield CJ. Inactivation of 1-aminocyclopropane-1-carboxylate oxidase involves oxidative modifications. Biochemistry. 36: 3563-9. PMID 9132007 DOI: 10.1021/Bi962521Y |
0.467 |
|
| 1997 |
Sami M, Brown TJ, Roach PL, Schofield CJ, Baldwin JE. Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans. Febs Letters. 405: 191-4. PMID 9089289 |
0.4 |
|
| 1997 |
Barlow JN, Baldwin JE, Clifton IJ, Gibson E, Hensgens CM, Hajdu J, Hara T, Hassan A, John P, Lloyd MD, Roach PL, Prescott A, Robinson JK, Zhang ZH, Schofield CJ. Studies on non-haem ferrous-dependent oxygenases and oxidases. Biochemical Society Transactions. 25: 86-90. PMID 9056849 DOI: 10.1042/Bst0250086 |
0.617 |
|
| 1997 |
Adlington RM, Baldwin JE, MC Coull W, Pritchard GJ, Schofield CJ, Westwood NJ. An Investigation of the N-Arylsulfonylation of 2-Azetidinones Synthetic Communications. 27: 3803-3813. DOI: 10.1080/00397919708007305 |
0.677 |
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