| Year |
Citation |
Score |
| 2023 |
Gazquez Casals A, Berkowitz AJ, Yu AJ, Waters HE, Schiavone DV, Kapkayeva DM, Morrison LA, Murelli RP. Antiviral activity of amide-appended α-hydroxytropolones against herpes simplex virus-1 and -2. Rsc Advances. 13: 8743-8752. PMID 36936842 DOI: 10.1039/d2ra06749h |
0.302 |
|
| 2020 |
Li Q, Lomonosova E, Donlin MJ, Cao F, O'Dea A, Milleson B, Berkowitz AJ, Baucom JC, Stasiak JP, Schiavone DV, Abdelmessih RG, Lyubimova A, Fraboni AJ, Bejcek LP, Villa JA, ... Murelli RP, et al. Amide-containing α-hydroxytropolones as inhibitors of hepatitis B virus replication. Antiviral Research. 104777. PMID 32217151 DOI: 10.1016/J.Antiviral.2020.104777 |
0.361 |
|
| 2020 |
Bejcek LP, Murelli RP. Synthesis of aryl-substituted 2-methoxyphenol derivatives from maltol-derived oxidopyrylium cycloadducts through an acid-mediated ring contraction cascade. Chemical Communications (Cambridge, England). PMID 32068199 DOI: 10.1039/C9Cc09213G |
0.402 |
|
| 2020 |
Lanave G, Martella V, Tempesta M, Catella C, Murelli RP, Morrison LA, Lucente MS, Buonavoglia C, Camero M. Antiviral activity of Α-hydroxytropolones on caprine alphaherpesvirus 1 in vitro. Research in Veterinary Science. 129: 99-102. PMID 31954321 DOI: 10.1016/J.Rvsc.2020.01.011 |
0.391 |
|
| 2019 |
Agyemang NB, Kukla CR, Edwards TC, Li Q, Langen MK, Schaal A, Franson AD, Casals AG, Donald KA, Yu AJ, Donlin MJ, Morrison LA, Tavis JE, Murelli RP. Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile. Rsc Advances. 9: 34227-34234. PMID 33042521 DOI: 10.1039/C9Ra06383H |
0.395 |
|
| 2019 |
Stasiak JP, Grigoryan A, Murelli RP. Spectrophotometric determination of α-hydroxytropolone p values: A structure-acidity relationship study. Tetrahedron Letters. 60: 1643-1645. PMID 32855576 DOI: 10.1016/J.Tetlet.2019.05.034 |
0.359 |
|
| 2019 |
Bejcek LP, Garimallaprabhakaran AK, Suyabatmaz DM, Greer A, Hersh WH, Greer EM, Murelli RP. Maltol- and allomaltol-derived oxidopyrylium ylides: Methyl substitution pattern kinetically influences [5 + 3] dimerization versus [5 + 2] cycloaddition reactions. The Journal of Organic Chemistry. PMID 31603325 DOI: 10.1021/Acs.Joc.9B02137 |
0.345 |
|
| 2019 |
Berkowitz AJ, Franson AD, Gazquez Cassals A, Donald KA, Yu AJ, Garimallaprabhakaran AK, Morrison LA, Murelli RP. Importance of lipophilicity for potent anti-herpes simplex virus-1 activity of α-hydroxytropolones. Medchemcomm. 10: 1173-1176. PMID 31391890 DOI: 10.1039/C9Md00225A |
0.395 |
|
| 2019 |
Hirsch DR, Metrano AJ, Stone EA, Storch G, Miller SJ, Murelli RP. Troponoid Atropisomerism: Studies on the Configurational Stability of Tropone-Amide Chiral Axes. Organic Letters. PMID 30869521 DOI: 10.1021/Acs.Orglett.9B00707 |
0.316 |
|
| 2019 |
Agyemang NB, Murelli RP, Jackson RK, Wood JL. Synthesis of 5‐Hydroxy‐4‐Methoxy‐2‐Methylpyrylium Trifluoromethanesulfonate from Kojic Acid Organic Syntheses. 96: 494-510. DOI: 10.1002/0471264229.Os096.30 |
0.489 |
|
| 2018 |
Berkowitz AJ, Abdelmessih RG, Murelli RP. Amidation Strategy for Final-Step α-Hydroxytropolone Diversification. Tetrahedron Letters. 59: 3026-3028. PMID 30872871 DOI: 10.1016/J.Tetlet.2018.06.063 |
0.452 |
|
| 2018 |
Miller JT, Zhao H, Masaoka T, Varnado B, Cornejo Castro EM, Marshall VA, Kouhestani K, Lynn AY, Aron KE, Xia A, Beutler JA, Hirsch DR, Tang L, Whitby D, Murelli RP, et al. Sensitivity of the C-terminal nuclease domain of Kaposi's sarcoma-associated herpesvirus ORF29 to two classes of active site ligands. Antimicrobial Agents and Chemotherapy. PMID 30061278 DOI: 10.1128/Aac.00233-18 |
0.365 |
|
| 2018 |
Tavis JE, Zoidis G, Meyers MJ, Murelli RP. Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H. Acs Infectious Diseases. PMID 29565562 DOI: 10.1021/Acsinfecdis.8B00045 |
0.318 |
|
| 2018 |
Dehghanpir SD, Birkenheuer CH, Yang K, Murelli RP, Morrison LA, Le Grice SFJ, Baines JD. Broad anti-herpesviral activity of α-hydroxytropolones. Veterinary Microbiology. 214: 125-131. PMID 29408023 DOI: 10.1016/J.Vetmic.2017.12.016 |
0.402 |
|
| 2018 |
D'Erasmo MP, Murelli RP. Fluorous-Phase Approach to α-Hydroxytropolone Synthesis. The Journal of Organic Chemistry. PMID 29338231 DOI: 10.1021/Acs.Joc.7B03032 |
0.366 |
|
| 2017 |
Fuhr KN, Hirsch DR, Murelli RP, Brenner-Moyer SE. Catalytic Enantioselective Intermolecular [5 + 2] Dipolar Cycloadditions of a 3-Hydroxy-4-pyrone-Derived Oxidopyrylium Ylide. Organic Letters. PMID 29148809 DOI: 10.1021/Acs.Orglett.7B03196 |
0.405 |
|
| 2017 |
Hirsch DR, Schiavone DV, Berkowitz AJ, Morrison LA, Masaoka T, Wilson JA, Lomonosova E, Zhao H, Patel BS, Datla SH, Hoft SG, Majidi SJ, Pal RK, Gallicchio E, Tang L, ... Murelli RP, et al. Synthesis and biological assessment of 3,7-dihydroxytropolones. Organic & Biomolecular Chemistry. PMID 29098212 DOI: 10.1039/C7Ob02453C |
0.4 |
|
| 2017 |
Grady LM, Szczepaniak R, Murelli RP, Masaoka T, Le Grice SFJ, Wright DL, Weller SK. The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus. Journal of Virology. PMID 28956767 DOI: 10.1128/Jvi.01380-17 |
0.313 |
|
| 2017 |
Lomonosova E, Daw J, Garimallaprabhakaran AK, Agyemang NB, Ashani Y, Murelli RP, Tavis JE. Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of Hepatitis B virus ribonuclease H. Antiviral Research. PMID 28633989 DOI: 10.1016/J.Antiviral.2017.06.014 |
0.377 |
|
| 2017 |
Donlin MJ, Zunica A, Lipnicky A, Garimallaprabhakaran AK, Berkowitz AJ, Grigoryan A, Meyers MJ, Tavis JE, Murelli RP. Troponoids can inhibit growth of the human fungal pathogen Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. PMID 28167553 DOI: 10.1128/Aac.02574-16 |
0.326 |
|
| 2016 |
Murelli RP, D'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zhang B, Pal RK, Gallicchio E, Beutler JA, Le Grice SF. Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity. Medchemcomm. 7: 1783-1788. PMID 28093576 DOI: 10.1039/C6Md00238B |
0.783 |
|
| 2016 |
D'Erasmo MP, Masaoka T, Wilson JA, Hunte EM, Beutler JA, Le Grice SF, Murelli RP. Traceless Solid-Phase α-Hydroxytropolone Synthesis. Medchemcomm. 7: 1789-1792. PMID 28090282 DOI: 10.1039/C6Md00237D |
0.394 |
|
| 2016 |
D'Erasmo MP, Meck C, Lewis CA, Murelli RP. Discovery and Development of a Three-Component Oxidopyrylium [5+2] Cycloaddition. The Journal of Organic Chemistry. PMID 27018974 DOI: 10.1021/Acs.Joc.6B00394 |
0.775 |
|
| 2016 |
Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Varnado B, Gupta A, Meyers MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SF. Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors. Biochemistry. PMID 26829613 DOI: 10.1021/Acs.Biochem.5B01254 |
0.767 |
|
| 2016 |
Ireland PJ, Tavis JE, D'Erasmo MP, Hirsch DR, Murelli RP, Cadiz MM, Patel BS, Gupta AK, Edwards TC, Korom M, Moran EA, Morrison LA. Synthetic α-hydroxytropolones inhibit replication of wild-type and acyclovir-resistant herpes simplex viruses. Antimicrobial Agents and Chemotherapy. PMID 26787704 DOI: 10.1128/Aac.02675-15 |
0.383 |
|
| 2015 |
Lu G, Lomonosova E, Cheng X, Moran EA, Meyers MJ, Le Grice SF, Thomas CJ, Jiang JK, Meck C, Hirsch DR, D'Erasmo MP, Suyabatmaz DM, Murelli RP, Tavis JE. Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity. Antimicrobial Agents and Chemotherapy. 59: 1070-9. PMID 25451058 DOI: 10.1128/Aac.04617-14 |
0.754 |
|
| 2014 |
Hirsch DR, Cox G, D'Erasmo MP, Shakya T, Meck C, Mohd N, Wright GD, Murelli RP. Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones. Bioorganic & Medicinal Chemistry Letters. 24: 4943-7. PMID 25283553 DOI: 10.1016/J.Bmcl.2014.09.037 |
0.733 |
|
| 2014 |
Meck C, D'Erasmo MP, Hirsch DR, Murelli RP. The biology and synthesis of α-hydroxytropolones. Medchemcomm. 5: 842-852. PMID 25089179 DOI: 10.1039/C4Md00055B |
0.781 |
|
| 2014 |
D'Erasmo MP, Smith WB, Munoz A, Mohandas P, Au AS, Marineau JJ, Quadri LE, Bradner JE, Murelli RP. 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds. Bioorganic & Medicinal Chemistry Letters. 24: 4035-8. PMID 25011911 DOI: 10.1016/J.Bmcl.2014.05.102 |
0.767 |
|
| 2013 |
Williams YD, Meck C, Mohd N, Murelli RP. Triflic acid-mediated rearrangements of 3-methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: synthesis of methoxytropolones and furans. The Journal of Organic Chemistry. 78: 11707-13. PMID 24171600 DOI: 10.1021/Jo401617R |
0.721 |
|
| 2012 |
Munoz A, Murelli RP. Acid-mediated coupling of γ-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones. Tetrahedron Letters. 53: 6779-6781. PMID 23335822 DOI: 10.1016/J.Tetlet.2012.09.139 |
0.571 |
|
| 2012 |
Meck C, Mohd N, Murelli RP. An oxidopyrylium cyclization/ring-opening route to polysubstituted α-hydroxytropolones. Organic Letters. 14: 5988-91. PMID 23167954 DOI: 10.1021/Ol302892G |
0.746 |
|
| 2012 |
Zhang AX, Hoimes CJ, Murelli RP, Saltzman WM, Spiegel DA. Abstract 4747: Redirecting the endogenous immune response against prostate cancer using an antibody-recruiting small molecule Cancer Research. 72: 4747-4747. DOI: 10.1158/1538-7445.Am2012-4747 |
0.579 |
|
| 2011 |
Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmierczak BI, Spiegel DA. Correction to A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules Acs Chemical Biology. 6: 971-971. DOI: 10.1021/Cb200283S |
0.746 |
|
| 2010 |
Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmierczak BI, Kazmiercak BI, Spiegel DA. A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules. Acs Chemical Biology. 5: 1147-55. PMID 20923200 DOI: 10.1021/Cb100195D |
0.751 |
|
| 2010 |
Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA. A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules. Journal of the American Chemical Society. 132: 12711-6. PMID 20726553 DOI: 10.1021/Ja104591M |
0.591 |
|
| 2010 |
Hoimes CJ, Murelli RP, Kelly WK, Zhang AX, Cheng CJ, Fields RJ, Spiegel DA, Saltzman WM. Effect of vorinostat (V)-loaded PLGA nanoparticles (NP) surface modified with a PSMA ligand on prostate cancer (PC) cells. Journal of Clinical Oncology. 28: e13629-e13629. DOI: 10.1200/Jco.2010.28.15_Suppl.E13629 |
0.512 |
|
| 2009 |
Stern E, Jay SM, Demento SL, Murelli RP, Reed MA, Malinski T, Spiegel DA, Mooney DJ, Fahmy TM. Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials. 19: 2888-2895. PMID 20445826 DOI: 10.1002/Adfm.200900307 |
0.43 |
|
| 2009 |
Murelli RP, Zhang AX, Michel J, Jorgensen WL, Spiegel DA. Chemical control over immune recognition: a class of antibody-recruiting small molecules that target prostate cancer. Journal of the American Chemical Society. 131: 17090-2. PMID 19888723 DOI: 10.1021/Ja906844E |
0.6 |
|
| 2009 |
Stern E, Jay SM, Demento SL, Murelli RP, Reed MA, Malinski T, Spiegel DA, Mooney DJ, Fahmy TM. Surface Patterning: Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro- and Nanopatterned Surfaces(Adv. Funct. Mater. 18/2009) Advanced Functional Materials. 19: NA-NA. DOI: 10.1002/Adfm.200990084 |
0.387 |
|
| 2008 |
Murelli RP, Catalán S, Gannon MP, Snapper ML. Ruthenium-catalyzed tandem enyne-cross metathesis-cyclopropanation: three-component access to vinyl cyclopropanes Tetrahedron Letters. 49: 5714-5717. DOI: 10.1016/J.Tetlet.2008.07.119 |
0.61 |
|
| 2007 |
Murelli RP, Snapper ML. Ruthenium-catalyzed tandem cross-metathesis/Wittig olefination: generation of conjugated dienoic esters from terminal olefins. Organic Letters. 9: 1749-52. PMID 17397176 DOI: 10.1021/Ol070445T |
0.588 |
|
| 2007 |
Murelli RP, Cheung AK, Snapper ML. Conformationally restricted (+)-cacospongionolide B analogues. Influence on secretory phospholipase A2 inhibition. The Journal of Organic Chemistry. 72: 1545-52. PMID 17315974 DOI: 10.1021/Jo061407A |
0.723 |
|
| 2004 |
Cheung AK, Murelli R, Snapper ML. Total syntheses of (+)- and (-)-cacospongionolide B, cacospongionolide e, and related analogues. Preliminary study of structural features required for phospholipase a2 inhibition. The Journal of Organic Chemistry. 69: 5712-9. PMID 15307744 DOI: 10.1021/Jo049285E |
0.721 |
|
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