Kuan-Wei Peng, Ph.D.

Affiliations: 
2009 University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Toxicology, Endocrinology Biology
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"Kuan-Wei Peng"
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Parents

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Judy L. Bolton grad student 2009 University of Illinois at Chicago, Health Sciences Center
 (Carcinogenesis of the equine estrogen metabolites and estrogen receptor targeted chemotherapeutic agents.)
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Publications

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Peng KW, Chang M, Wang YT, et al. (2010) Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83
Wang Z, Chandrasena ER, Yuan Y, et al. (2010) Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chemical Research in Toxicology. 23: 1365-73
Peng KW, Wang H, Qin Z, et al. (2009) Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. Acs Chemical Biology. 4: 1039-49
Wang Z, Wijewickrama GT, Peng KW, et al. (2009) Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. The Journal of Biological Chemistry. 284: 8633-42
Chang M, Overk CR, Kastrati I, et al. (2008) Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7
Overk CR, Peng KW, Asghodom RT, et al. (2007) Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6
Chang M, Peng KW, Kastrati I, et al. (2007) Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802
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