Kelly Seaton, Ph.D.

Affiliations: 
2009 Pennsylvania State University, State College, PA, United States 
Area:
Pharmacology, Virology Biology
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Jong K. Yun grad student 2009 Penn State
 (The human N-myristoyltransferases as potential pharmacotherapeutic targets in HIV-1 replication.)
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Publications

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Frank I, Li SS, Grunenberg N, et al. (2024) Safety and immunogenicity of a polyvalent DNA-protein HIV vaccine with matched Env immunogens delivered as a prime-boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial. The Lancet. Hiv. 11: e285-e299
Moodie Z, Andersen-Nissen E, Grunenberg N, et al. (2024) Safety and immunogenicity of a subtype C ALVAC-HIV (vCP2438) vaccine prime plus bivalent subtype C gp120 vaccine boost adjuvanted with MF59 or alum in healthy adults without HIV (HVTN 107): A phase 1/2a randomized trial. Plos Medicine. 21: e1004360
Walsh SR, Gay CL, Karuna ST, et al. (2024) A Randomised Clinical Trial of the Safety and Pharmacokinetics of VRC07-523LS Administered via Different Routes and Doses (HVTN 127/HPTN 087). Medrxiv : the Preprint Server For Health Sciences
Reeves DB, Mayer BT, deCamp AC, et al. (2023) High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials. Nature Communications. 14: 8299
Sobieszczyk ME, Mannheimer S, Paez CA, et al. (2023) Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial. The Lancet. Hiv. 10: e653-e662
Chirenje ZM, Laher F, Dintwe O, et al. (2023) Protein dose-sparing effect of AS01B adjuvant in a randomized preventive HIV vaccine trial of ALVAC-HIV (vCP2438) and adjuvanted bivalent subtype C gp120. The Journal of Infectious Diseases
Tieu HV, Karuna S, Huang Y, et al. (2023) Safety and immunogenicity of a recombinant oligomeric gp145 subtype C Env protein (gp145 C.6980) HIV vaccine candidate in healthy, HIV-1-uninfected adult participants in the US. Vaccine
Seaton KE, Huang Y, Karuna S, et al. (2023) Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition. Ebiomedicine. 93: 104590
Mayer-Blackwell K, Johnson AM, Potchen N, et al. (2022) Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines. Frontiers in Immunology. 13: 983313
Huang Y, Zhang Y, Seaton KE, et al. (2022) Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens. Ebiomedicine. 84: 104271
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