Eric D. Spear, Ph.D.
Affiliations: | 2004 | Pennsylvania State University, State College, PA, United States |
Area:
Cell BiologyGoogle:
"Eric Spear"Parents
Sign in to add mentor| Davis Tai Wai Ng | grad student | 2004 | Penn State | |
| (Stress tolerance and ER quality control mechanisms of misfolded secretory proteins.) | ||||
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Publications
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| Wang W, Lu J, Yang WC, et al. (2022) Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control. The Journal of Biological Chemistry. 102851 |
| Spear ED, Hsu ET, Nie L, et al. (2018) missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability. Disease Models & Mechanisms |
| Maurer MJ, Spear ED, Yu AT, et al. (2016) Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast. G3 (Bethesda, Md.) |
| Lee AY, St Onge RP, Proctor MJ, et al. (2014) Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science (New York, N.Y.). 344: 208-11 |
| Kogan K, Spear ED, Kaiser CA, et al. (2010) Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals. Journal of Molecular Biology. 402: 388-98 |
| Kim W, Spear ED, Ng DT. (2005) Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Molecular Cell. 19: 753-64 |
| Spear ED, Ng DT. (2005) Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation. The Journal of Cell Biology. 169: 73-82 |
| Spear ED, Ng DT. (2003) Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways. Molecular Biology of the Cell. 14: 2756-67 |
| Vashist S, Kim W, Belden WJ, et al. (2001) Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding The Journal of Cell Biology. 155: 355-368 |
| Spear E, Ng DT. (2001) The unfolded protein response: no longer just a special teams player. Traffic (Copenhagen, Denmark). 2: 515-23 |