Daniela Bumbaca
Affiliations: | 2013-2016 | PTPK | Genentech, Inc., San Francisco, CA, United States |
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Publications
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| Lee SH, Le Pichon CE, Adolfsson O, et al. (2016) Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports |
| Kanodia JS, Gadkar K, Bumbaca D, et al. (2016) Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain. Cpt: Pharmacometrics & Systems Pharmacology. 5: 283-291 |
| Deng R, Bumbaca D, Pastuskovas CV, et al. (2016) Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. Mabs. 1-11 |
| Zuchero YJ, Chen X, Bien-Ly N, et al. (2015) Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron |
| Kinnunen HM, Sharma V, Contreras-Rojas LR, et al. (2015) A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components. Journal of Controlled Release : Official Journal of the Controlled Release Society. 214: 94-102 |
| Shen BQ, Bumbaca D, Yue Q, et al. (2015) Non-clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats. Drug Metabolism Letters |
| Uppal H, Doudement E, Mahapatra K, et al. (2015) Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 123-33 |
| Kamath AV, Yip V, Gupta P, et al. (2014) Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice. Mabs. 6: 1631-7 |
| Yu YJ, Atwal JK, Zhang Y, et al. (2014) Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154 |
| Boswell CA, Mundo EE, Ulufatu S, et al. (2014) Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues. Molecular Pharmaceutics. 11: 1591-8 |