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Daniela Bumbaca - Publications

Affiliations: 
2013-2016 PTPK Genentech, Inc., San Francisco, CA, United States 
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, ... ... Bumbaca D, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports. PMID 27475227 DOI: 10.1016/J.Celrep.2016.06.099  0.389
2016 Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, et al. Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain. Cpt: Pharmacometrics & Systems Pharmacology. 5: 283-291. PMID 27299941 DOI: 10.1002/psp4.12081  0.423
2016 Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. Mabs. 1-11. PMID 26918260 DOI: 10.1080/19420862.2015.1136043  0.408
2015 Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, et al. Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron. PMID 26687840 DOI: 10.1016/J.Neuron.2015.11.024  0.43
2015 Kinnunen HM, Sharma V, Contreras-Rojas LR, Yu Y, Alleman C, Sreedhara A, Fischer S, Khawli L, Yohe ST, Bumbaca D, Patapoff TW, Daugherty AL, Mrsny RJ. A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components. Journal of Controlled Release : Official Journal of the Controlled Release Society. 214: 94-102. PMID 26210441 DOI: 10.1016/J.Jconrel.2015.07.016  0.344
2015 Shen BQ, Bumbaca D, Yue Q, Saad O, Tibbitts J, Khojasteh SC, Girish S. Non-clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats. Drug Metabolism Letters. PMID 26031461 DOI: 10.2174/1872312809666150602151922  0.394
2015 Uppal H, Doudement E, Mahapatra K, Darbonne WC, Bumbaca D, Shen BQ, Du X, Saad O, Bowles K, Olsen S, Lewis Phillips GD, Hartley D, Sliwkowski MX, Girish S, Dambach D, et al. Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 123-33. PMID 25370470 DOI: 10.1158/1078-0432.Ccr-14-2093  0.34
2014 Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice. Mabs. 6: 1631-7. PMID 25484068 DOI: 10.4161/Mabs.36107  0.492
2014 Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154. PMID 25378646 DOI: 10.1126/Scitranslmed.3009835  0.463
2014 Boswell CA, Mundo EE, Ulufatu S, Bumbaca D, Cahaya HS, Majidy N, Van Hoy M, Schweiger MG, Fielder PJ, Prabhu S, Khawli LA. Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues. Molecular Pharmaceutics. 11: 1591-8. PMID 24702191 DOI: 10.1021/Mp400748T  0.389
2014 Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor. Mabs. 6: 689-96. PMID 24572100 DOI: 10.4161/Mabs.28254  0.501
2014 Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44. PMID 24470444 DOI: 10.1084/Jem.20131660  0.444
2013 Boswell CA, Marik J, Elowson MJ, Reyes NA, Ulufatu S, Bumbaca D, Yip V, Mundo EE, Majidy N, Van Hoy M, Goriparthi SN, Trias A, Gill HS, Williams SP, Junutula JR, et al. Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies. Journal of Medicinal Chemistry. 56: 9418-26. PMID 24131491 DOI: 10.1021/Jm401365H  0.385
2013 Boswell CA, Mundo EE, Johnstone B, Ulufatu S, Schweiger MG, Bumbaca D, Fielder PJ, Prabhu S, Khawli LA. Vascular physiology and protein disposition in a preclinical model of neurodegeneration. Molecular Pharmaceutics. 10: 1514-21. PMID 23383983 DOI: 10.1021/Mp3004786  0.392
2012 Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. A strategy for risk mitigation of antibodies with fast clearance. Mabs. 4: 753-60. PMID 23778268 DOI: 10.4161/Mabs.22189  0.493
2012 Boswell CA, Bumbaca D, Fielder PJ, Khawli LA. Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations. The Aaps Journal. 14: 612-8. PMID 22648903 DOI: 10.1208/S12248-012-9374-1  0.49
2012 Bumbaca D, Boswell CA, Fielder PJ, Khawli LA. Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics. The Aaps Journal. 14: 554-8. PMID 22610647 DOI: 10.1208/S12248-012-9369-Y  0.493
2012 Shen BQ, Bumbaca D, Saad O, Yue Q, Pastuskovas CV, Khojasteh SC, Tibbitts J, Kaur S, Wang B, Chu YW, LoRusso PM, Girish S. Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism. Current Drug Metabolism. 13: 901-10. PMID 22475269 DOI: 10.2174/138920012802138598  0.345
2012 Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, et al. Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration. Mabs. 4: 243-55. PMID 22453096 DOI: 10.4161/Mabs.4.2.19387  0.437
2012 Bumbaca D, Tong RK, Koch AW, Xiang H, DeForge LE, Shen BQ, Lu Y. A case study on Sema3E-Fc aggregation and assay-dependent differences in quantitation. Bioanalysis. 4: 703-11. PMID 22452261 DOI: 10.4155/Bio.12.30  0.354
2012 Pastuskovas CV, Mundo EE, Williams SP, Nayak TK, Ho J, Ulufatu S, Clark S, Ross S, Cheng E, Parsons-Reponte K, Cain G, Van Hoy M, Majidy N, Bheddah S, dela Cruz Chuh J, ... ... Bumbaca D, et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Molecular Cancer Therapeutics. 11: 752-62. PMID 22222630 DOI: 10.1158/1535-7163.Mct-11-0742-T  0.445
2012 Bumbaca D, Xiang H, Boswell CA, Port RE, Stainton SL, Mundo EE, Ulufatu S, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice. British Journal of Pharmacology. 166: 368-77. PMID 22074316 DOI: 10.1111/J.1476-5381.2011.01777.X  0.463
2011 Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, et al. Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats. Bioconjugate Chemistry. 22: 1994-2004. PMID 21913715 DOI: 10.1021/Bc200212A  0.521
2011 Bumbaca D, Wong A, Drake E, Reyes AE, Lin BC, Stephan JP, Desnoyers L, Shen BQ, Dennis MS. Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4. Mabs. 3: 376-86. PMID 21540647 DOI: 10.4161/Mabs.3.4.15786  0.475
2011 Boswell CA, Ferl GZ, Mundo EE, Bumbaca D, Schweiger MG, Theil FP, Fielder PJ, Khawli LA. Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow. Plos One. 6: e17874. PMID 21436893 DOI: 10.1371/Journal.Pone.0017874  0.429
2011 Bumbaca D, Boswell CA, Mundo EE, Xin Y, Xiang H, Port RE, Schweiger MG, Stainton SL, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Abstract 4588: Tumor distribution of anti-neuropilin-1 is affected by antibody dose level in a tumor xenograft mouse model Cancer Research. 71: 4588-4588. DOI: 10.1158/1538-7445.Am2011-4588  0.434
2011 Wong S, Bumbaca D, Yue Q, Halladay J, Kenny JR, Salphati L, Saad O, Tibbitts J, Khojasteh C, Girish S, Shen B. Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1). Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A136  0.389
2011 Mahapatra K, Darbonne W, Bumbaca D, Shen B, Du X, Tibbitts J, Olsen S, Sliwkowski M, Girish S, Hartley D, Dambach D, Ramakrishnan V, Uppal H. Abstract A135: T-DM1-induced thrombocytopenia results from impaired platelet production in a HER2-independent manner. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A135  0.36
2010 Bumbaca D, Boswell CA, Xiang H, Port R, Schweiger M, Stainton S, Bagri A, Theil F, Fielder PJ, Khawli LA, Shen B. Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model Cancer Research. 70: 696-696. DOI: 10.1158/1538-7445.Am10-696  0.429
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