Adam Patterson
Affiliations: | 1995-1999 | University of Oxford, Oxford, United Kingdom |
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"Adam Patterson"
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| Ashoorzadeh A, Mowday AM, Abbattista MR, et al. (2023) Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506. Acs Medicinal Chemistry Letters. 14: 1517-1523 |
| Ashoorzadeh A, Mowday AM, Guise CP, et al. (2022) Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications. Pharmaceuticals (Basel, Switzerland). 15 |
| Singleton DC, Mowday AM, Guise CP, et al. (2021) Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411 leading to therapeutic benefit. Cancer Gene Therapy |
| Fu Z, Mowday AM, Smaill JB, et al. (2021) Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy. Cells. 10 |
| Mowday AM, Dubois LJ, Kubiak AM, et al. (2021) Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours. Cancer Gene Therapy |
| Mowday AM, Copp JN, Syddall SP, et al. (2020) nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications. Theranostics. 10: 10548-10562 |
| Williams EM, Rich MH, Mowday AM, et al. (2019) Engineering NfsB to activate a hypoxia-resistant analog of the PET probe EF5 to enable non-invasive imaging during enzyme-prodrug therapy. Biochemistry |
| Chan-Hyams JVE, Copp JN, Smaill JB, et al. (2018) Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy. Biochemical Pharmacology |
| Copp JN, Mowday AM, Williams EM, et al. (2017) Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy. Cell Chemical Biology |
| Mowday AM, Ashoorzadeh A, Williams EM, et al. (2016) Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy. Biochemical Pharmacology |