Philip Leder - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Genetics
Website:
http://www.dfhcc.harvard.edu/insider/member-detail/member/philip-leder-md/

237 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Caskey CT, Leder P. The RNA code: nature's Rosetta Stone. Proceedings of the National Academy of Sciences of the United States of America. 111: 5758-9. PMID 24756939 DOI: 10.1073/pnas.1404819111  0.497
2009 Ravi D, Wiles AM, Bhavani S, Ruan J, Leder P, Bishop AJ. A network of conserved damage survival pathways revealed by a genomic RNAi screen. Plos Genetics. 5: e1000527. PMID 19543366 DOI: 10.1371/Journal.Pgen.1000527  0.763
2009 Zhou F, Leder P, Zuniga A, Dettenhofer M. Formin1 disruption confers oligodactylism and alters Bmp signaling. Human Molecular Genetics. 18: 2472-82. PMID 19383632 DOI: 10.1093/Hmg/Ddp185  0.366
2009 Babbe H, McMenamin J, Hobeika E, Wang J, Rodig SJ, Reth M, Leder P. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. Journal of Immunology (Baltimore, Md. : 1950). 182: 347-60. PMID 19109166 DOI: 10.4049/Jimmunol.182.1.347  0.325
2008 Dettenhofer M, Zhou F, Leder P. Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. Plos One. 3: e2497. PMID 18560567 DOI: 10.1371/Journal.Pone.0002497  0.308
2008 Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P. Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency. Oncogene. 27: 2456-65. PMID 17952114 DOI: 10.1038/Sj.Onc.1210866  0.591
2007 Li X, Leder P. Identifying genes preferentially expressed in undifferentiated embryonic stem cells. Bmc Cell Biology. 8: 37. PMID 17725840 DOI: 10.1186/1471-2121-8-37  0.438
2007 Lu J, Ruhf ML, Perrimon N, Leder P. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proceedings of the National Academy of Sciences of the United States of America. 104: 9381-6. PMID 17517653 DOI: 10.1073/Pnas.0610279104  0.652
2007 Babbe H, Chester N, Leder P, Reizis B. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Molecular and Cellular Biology. 27: 1947-59. PMID 17210642 DOI: 10.1128/Mcb.01402-06  0.331
2006 Chester N, Babbe H, Pinkas J, Manning C, Leder P. Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Molecular and Cellular Biology. 26: 6713-26. PMID 16914751 DOI: 10.1128/MCB.00296-06  0.395
2006 Zhou F, Leder P, Martin SS. Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Experimental Cell Research. 312: 1119-26. PMID 16480715 DOI: 10.1016/J.Yexcr.2005.12.035  0.552
2005 Leder A, McMenamin J, Fontaine K, Bishop A, Leder P. zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation. Human Molecular Genetics. 14: 615-25. PMID 15649944 DOI: 10.1093/Hmg/Ddi058  0.695
2004 Pinkas J, Martin SS, Leder P. Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. Molecular Cancer Research : McR. 2: 551-6. PMID 15498929  0.557
2004 Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 21: 43-53. PMID 15345219 DOI: 10.1016/J.Immuni.2004.06.011  0.394
2004 Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 23: 4641-5. PMID 15064711 DOI: 10.1038/Sj.Onc.1207595  0.567
2003 McDaniel LD, Chester N, Watson M, Borowsky AD, Leder P, Schultz RA. Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. Dna Repair. 2: 1387-404. PMID 14642567 DOI: 10.1016/J.Dnarep.2003.08.006  0.355
2003 Michaelson JS, Leder P. RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. Journal of Cell Science. 116: 345-52. PMID 12482920 DOI: 10.1242/jcs.00234  0.373
2002 Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P. Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nature Cell Biology. 4: 921-8. PMID 12447394 DOI: 10.1038/Ncb880  0.778
2002 Leder A, Lebel M, Zhou F, Fontaine K, Bishop A, Leder P. Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. Oncogene. 21: 6657-68. PMID 12242664 DOI: 10.1038/Sj.Onc.1205795  0.695
2002 Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2: 29-42. PMID 12150823 DOI: 10.1016/S1535-6108(02)00082-X  0.525
2002 Reizis B, Leder P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes & Development. 16: 295-300. PMID 11825871 DOI: 10.1101/Gad.960702  0.348
2002 Weiss RS, Matsuoka S, Elledge SJ, Leder P. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Current Biology : Cb. 12: 73-7. PMID 11790307 DOI: 10.1016/S0960-9822(01)00626-1  0.305
2001 Vollrath B, Pudney J, Asa S, Leder P, Fitzgerald K. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. Molecular and Cellular Biology. 21: 7481-94. PMID 11585928 DOI: 10.1128/MCB.21.21.7481-7494.2001  0.432
2001 Reizis B, Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. The Journal of Experimental Medicine. 194: 979-90. PMID 11581319 DOI: 10.1084/Jem.194.7.979  0.393
2001 Martin SS, Leder P. Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2. Molecular and Cellular Biology. 21: 6529-36. PMID 11533241 DOI: 10.1128/Mcb.21.19.6529-6536.2001  0.576
2001 Goodwin NC, Ishida Y, Hartford S, Wnek C, Bergstrom RA, Leder P, Schimenti JC. DelBank: a mouse ES-cell resource for generating deletions. Nature Genetics. 28: 310-1. PMID 11479588 DOI: 10.1038/91064  0.325
2001 Vollrath B, Fitzgerald KJ, Leder P. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Molecular and Cellular Biology. 21: 5688-97. PMID 11463849 DOI: 10.1128/MCB.21.16.5688-5697.2001  0.382
2001 Brodie SG, Xu X, Li C, Kuo A, Leder P, Deng CX. Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis. Oncogene. 20: 1445-54. PMID 11313888 DOI: 10.1038/Sj.Onc.1204222  0.313
2000 Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene. 19: 4191-8. PMID 10980592 DOI: 10.1038/sj.onc.1203766  0.334
2000 Lane TF, Lin C, Brown MA, Solomon E, Leder P. Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene. 19: 4085-90. PMID 10962568 DOI: 10.1038/sj.onc.1203760  0.416
2000 Weiss RS, Enoch T, Leder P. Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes & Development. 14: 1886-98. PMID 10921903 DOI: 10.1101/Gad.14.15.1886  0.372
2000 Weinstein EJ, Leder P. The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis. Cancer Research. 60: 3856-61. PMID 10919660  0.696
2000 Weinstein EJ, Kitsberg DI, Leder P. A mouse model for breast cancer induced by amplification and overexpression of the neu promoter and transgene. Molecular Medicine (Cambridge, Mass.). 6: 4-16. PMID 10803404 DOI: 10.1007/Bf03401930  0.723
2000 Leader B, Leder P. Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system. Mechanisms of Development. 93: 221-31. PMID 10781961 DOI: 10.1016/S0925-4773(00)00276-8  0.778
2000 Reizis B, Lee JT, Leder P. Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 63: 149-52. PMID 10662556 DOI: 10.1006/Geno.1999.6068  0.393
1999 Lebel M, Spillare EA, Harris CC, Leder P. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. The Journal of Biological Chemistry. 274: 37795-9. PMID 10608841 DOI: 10.1074/jbc.274.53.37795  0.361
1999 Ishida Y, Leder P. RET: a poly A-trap retrovirus vector for reversible disruption and expression monitoring of genes in living cells. Nucleic Acids Research. 27: e35. PMID 10572187 DOI: 10.1093/Nar/27.24.E35  0.434
1999 Michaelson JS, Bader D, Kuo F, Kozak C, Leder P. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes & Development. 13: 1918-23. PMID 10444590 DOI: 10.1101/Gad.13.15.1918  0.36
1999 Weiss RS, Kostrub CF, Enoch T, Leder P. Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene. Genomics. 59: 32-9. PMID 10395797 DOI: 10.1006/geno.1999.5865  0.442
1999 Leder A, Wiener E, Lee MJ, Wickramasinghe SN, Leder P. A normal beta-globin allele as a modifier gene ameliorating the severity of alpha-thalassemia in mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6291-5. PMID 10339580 DOI: 10.1073/pnas.96.11.6291  0.319
1999 Reizis B, Leder P. Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer. The Journal of Experimental Medicine. 189: 1669-78. PMID 10330446 DOI: 10.1084/Jem.189.10.1669  0.425
1999 Chen H, Leder P. A new signal sequence trap using alkaline phosphatase as a reporter. Nucleic Acids Research. 27: 1219-22. PMID 9927759 DOI: 10.1093/Nar/27.4.1219  0.695
1998 Chao CW, Chan DC, Kuo A, Leder P. The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis. Molecular Medicine (Cambridge, Mass.). 4: 614-28. PMID 9848078 DOI: 10.1007/Bf03401761  0.433
1998 Chester N, Kuo F, Kozak C, O'Hara CD, Leder P. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes & Development. 12: 3382-93. PMID 9808625 DOI: 10.1101/Gad.12.21.3382  0.414
1998 Weinstein EJ, Grimm S, Leder P. The oncogene heregulin induces apoptosis in breast epithelial cells and tumors. Oncogene. 17: 2107-13. PMID 9798682 DOI: 10.1038/Sj.Onc.1202428  0.733
1998 Lebel M, Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proceedings of the National Academy of Sciences of the United States of America. 95: 13097-102. PMID 9789047 DOI: 10.1073/pnas.95.22.13097  0.422
1998 Grimm S, Weinstein EJ, Krane IM, Leder P. Neu differentiation factor (NDF), a dominant oncogene, causes apoptosis in vitro and in vivo. The Journal of Experimental Medicine. 188: 1535-9. PMID 9782131 DOI: 10.1084/Jem.188.8.1535  0.704
1998 Bedford MT, Reed R, Leder P. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proceedings of the National Academy of Sciences of the United States of America. 95: 10602-7. PMID 9724750 DOI: 10.1073/Pnas.95.18.10602  0.506
1998 Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity. 8: 297-303. PMID 9529147 DOI: 10.1016/S1074-7613(00)80535-X  0.31
1997 Lane TF, Leder P. Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice. Oncogene. 15: 2133-44. PMID 9393971 DOI: 10.1038/sj.onc.1201593  0.357
1997 Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nature Genetics. 16: 397-401. PMID 9241281 DOI: 10.1038/Ng0897-397  0.343
1997 Wynshaw-Boris A, Ryan G, Deng CX, Chan DC, Jackson-Grusby L, Larson D, Dunmore JH, Leder P. The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Molecular Medicine (Cambridge, Mass.). 3: 372-84. PMID 9234242 DOI: 10.1007/Bf03401684  0.72
1997 Westphal CH, Leder P. Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice. Current Biology : Cb. 7: 530-3. PMID 9210379 DOI: 10.1016/S0960-9822(06)00224-7  0.393
1997 Deng C, Bedford M, Li C, Xu X, Yang X, Dunmore J, Leder P. Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development. Developmental Biology. 185: 42-54. PMID 9169049 DOI: 10.1006/Dbio.1997.8553  0.314
1997 Wang CC, Chan DC, Leder P. The mouse formin (Fmn) gene: genomic structure, novel exons, and genetic mapping. Genomics. 39: 303-11. PMID 9119367 DOI: 10.1006/geno.1996.4519  0.422
1997 Grimm S, Leder P. An apoptosis-inducing isoform of neu differentiation factor (NDF) identified using a novel screen for dominant, apoptosis-inducing genes. The Journal of Experimental Medicine. 185: 1137-42. PMID 9091587 DOI: 10.1084/jem.185.6.1137  0.399
1997 Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. The Journal of Experimental Medicine. 185: 785-90. PMID 9034156 DOI: 10.1084/Jem.185.4.785  0.323
1996 Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, Campos-Torres J, Leder P. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 13084-9. PMID 8917548 DOI: 10.1073/Pnas.93.23.13084  0.352
1996 Kelliher MA, Seldin DC, Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. The Embo Journal. 15: 5160-6. PMID 8895560 DOI: 10.1002/J.1460-2075.1996.Tb00900.X  0.345
1996 Grimm S, Stanger BZ, Leder P. RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways. Proceedings of the National Academy of Sciences of the United States of America. 93: 10923-7. PMID 8855284 DOI: 10.1073/Pnas.93.20.10923  0.316
1996 Elson A, Kozak CA, Morton CC, Weremowicz S, Leder P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics. 31: 373-5. PMID 8838320 DOI: 10.1006/Geno.1996.0061  0.397
1996 Chan DC, Leder P. Genetic evidence that formins function within the nucleus. The Journal of Biological Chemistry. 271: 23472-7. PMID 8798555 DOI: 10.1074/jbc.271.38.23472  0.343
1996 Vogt TF, Leder P. Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles. Developmental Genetics. 19: 33-42. PMID 8792607 DOI: 10.1002/(SICI)1520-6408(1996)19:1<33::AID-DVG4>3.0.CO;2-1  0.335
1996 Rothenberg ME, Ownbey R, Mehlhop PD, Loiselle PM, van de Rijn M, Bonventre JV, Oettgen HC, Leder P, Luster AD. Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Molecular Medicine (Cambridge, Mass.). 2: 334-48. PMID 8784786 DOI: 10.1007/Bf03401631  0.301
1996 Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nature Medicine. 2: 449-56. PMID 8597956 DOI: 10.1038/nm0496-449  0.31
1995 Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proceedings of the National Academy of Sciences of the United States of America. 92: 12235-9. PMID 8618876 DOI: 10.1073/Pnas.92.26.12235  0.372
1995 Lee FS, Lane TF, Kuo A, Shackleford GM, Leder P. Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 92: 2268-72. PMID 7892260 DOI: 10.1073/pnas.92.6.2268  0.385
1995 Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. The Journal of Experimental Medicine. 181: 1211-6. PMID 7869037 DOI: 10.1084/jem.181.3.1211  0.326
1995 Seldin DC, Leder P. Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. Science (New York, N.Y.). 267: 894-7. PMID 7846532 DOI: 10.1126/Science.7846532  0.31
1995 Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. The Journal of Biological Chemistry. 270: 2176-82. PMID 7836447 DOI: 10.1074/jbc.270.5.2176  0.344
1995 Chaillet JR, Bader DS, Leder P. Regulation of genomic imprinting by gametic and embryonic processes. Genes & Development. 9: 1177-87. PMID 7758943 DOI: 10.1101/Gad.9.10.1177  0.329
1995 Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. The Journal of Experimental Medicine. 181: 1603-13. PMID 7722440 DOI: 10.1084/Jem.181.5.1603  0.518
1995 Elson A, Leder P. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu. The Journal of Biological Chemistry. 270: 26116-22. PMID 7592814 DOI: 10.1074/Jbc.270.44.26116  0.347
1995 Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes & Development. 9: 2712-22. PMID 7590247 DOI: 10.1101/Gad.9.21.2712  0.408
1995 Rothenberg ME, Luster AD, Leder P. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proceedings of the National Academy of Sciences of the United States of America. 92: 8960-4. PMID 7568052 DOI: 10.1073/pnas.92.19.8960  0.401
1995 Stanger BZ, Leder P, Lee TH, Kim E, Seed B. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 81: 513-23. PMID 7538908 DOI: 10.1016/0092-8674(95)90072-1  0.323
1994 Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P. Active anaphylaxis in IgE-deficient mice. Nature. 370: 367-70. PMID 8047141 DOI: 10.1038/370367A0  0.327
1994 Deng CX, Wynshaw-Boris A, Shen MM, Daugherty C, Ornitz DM, Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes & Development. 8: 3045-57. PMID 8001823 DOI: 10.1101/Gad.8.24.3045  0.324
1993 Vogt TF, Jackson-Grusby L, Rush J, Leder P. Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus. Proceedings of the National Academy of Sciences of the United States of America. 90: 5554-8. PMID 8516300 DOI: 10.1073/Pnas.90.12.5554  0.733
1993 Skoda RC, Seldin DC, Chiang MK, Peichel CL, Vogt TF, Leder P. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. The Embo Journal. 12: 2645-53. PMID 8334987 DOI: 10.1002/J.1460-2075.1993.Tb05925.X  0.618
1993 Levinson DA, Campos-Torres J, Leder P. Molecular characterization of transgene-induced immunodeficiency in B-less mice using a novel quantitative limiting dilution polymerase chain reaction method. The Journal of Experimental Medicine. 178: 317-29. PMID 8315387 DOI: 10.1084/Jem.178.1.317  0.337
1992 Vogt TF, Jackson-Grusby L, Wynshaw-Boris AJ, Chan DC, Leder P. The same genomic region is disrupted in two transgene-induced limb deformity alleles. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 3: 431-7. PMID 1643305 DOI: 10.1007/BF00356152  0.754
1992 Kwan H, Pecenka V, Tsukamoto A, Parslow TG, Guzman R, Lin TP, Muller WJ, Lee FS, Leder P, Varmus HE. Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Molecular and Cellular Biology. 12: 147-54. PMID 1530875 DOI: 10.1128/Mcb.12.1.147  0.334
1992 Shen MM, Leder P. Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 89: 8240-4. PMID 1518852 DOI: 10.1073/Pnas.89.17.8240  0.312
1992 Benvenisty N, Leder A, Kuo A, Leder P. An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. Genes & Development. 6: 2513-23. PMID 1340466 DOI: 10.1101/Gad.6.12B.2513  0.407
1992 Jackson-Grusby L, Kuo A, Leder P. A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin. Genes & Development. 6: 29-37. PMID 1339380 DOI: 10.1101/Gad.6.1.29  0.725
1992 Ornitz DM, Cardiff RD, Kuo A, Leder P. Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants. Journal of the National Cancer Institute. 84: 887-92. PMID 1317463 DOI: 10.1093/Jnci/84.11.887  0.347
1992 Vasicek TJ, Levinson DA, Schmidt EV, Campos-Torres J, Leder P. B-less: a strain of profoundly B cell-deficient mice expressing a human lambda transgene. The Journal of Experimental Medicine. 175: 1169-80. PMID 1314882 DOI: 10.1084/Jem.175.5.1169  0.356
1992 Ornitz DM, Yayon A, Flanagan JG, Svahn CM, Levi E, Leder P. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Molecular and Cellular Biology. 12: 240-7. PMID 1309590 DOI: 10.1128/Mcb.12.1.240  0.449
1991 Sussman DJ, Chung J, Leder P. In vitro and in vivo analysis of the c-myc RNA polymerase III promoter. Nucleic Acids Research. 19: 5045-52. PMID 1923771 DOI: 10.1093/Nar/19.18.5045  0.311
1991 Ornitz DM, Moreadith RW, Leder P. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proceedings of the National Academy of Sciences of the United States of America. 88: 698-702. PMID 1846961 DOI: 10.1073/Pnas.88.3.698  0.376
1991 Flanagan JG, Chan DC, Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell. 64: 1025-35. PMID 1705866 DOI: 10.1016/0092-8674(91)90326-T  0.511
1991 Maas RL, Jepeal LI, Elfering SL, Holcombe RF, Morton CC, Eddy RL, Byers MG, Shows TB, Leder P. A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs. American Journal of Human Genetics. 48: 687-95. PMID 1673046  0.31
1991 Beier DR, Chaillet JR, Schmidt EV, Leder P. Close linkage of a transgene insertion site to the steel (Sl) locus on mouse chromosome 10. Genomics. 10: 1003-8. PMID 1655629 DOI: 10.1016/0888-7543(91)90191-G  0.589
1991 Chaillet JR, Vogt TF, Beier DR, Leder P. Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell. 66: 77-83. PMID 1649008 DOI: 10.1016/0092-8674(91)90140-T  0.543
1990 Mass RL, Zeller R, Woychik RP, Vogt TF, Leder P. Disruption of formin-encoding transcripts in two mutant limb deformity alleles. Nature. 346: 853-5. PMID 2392151 DOI: 10.1038/346853A0  0.436
1990 Woychik RP, Maas RL, Zeller R, Vogt TF, Leder P. 'Formins': proteins deduced from the alternative transcripts of the limb deformity gene. Nature. 346: 850-3. PMID 2392150 DOI: 10.1038/346850A0  0.65
1990 Leder A, Kuo A, Cardiff RD, Sinn E, Leder P. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proceedings of the National Academy of Sciences of the United States of America. 87: 9178-82. PMID 2251261 DOI: 10.1073/pnas.87.23.9178  0.326
1990 Shaw AC, Mitchell RN, Weaver YK, Campos-Torres J, Abbas AK, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell. 63: 381-92. PMID 2119890 DOI: 10.1016/0092-8674(90)90171-A  0.336
1990 Tepper RI, Levinson DA, Stanger BZ, Campos-Torres J, Abbas AK, Leder P. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 62: 457-67. PMID 2116236 DOI: 10.1016/0092-8674(90)90011-3  0.303
1990 Vasicek TJ, Leder P. Structure and expression of the human immunoglobulin lambda genes. The Journal of Experimental Medicine. 172: 609-20. PMID 2115572 DOI: 10.1084/jem.172.2.609  0.46
1990 Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 63: 225-33. PMID 1698557 DOI: 10.1016/0092-8674(90)90303-V  0.616
1990 Flanagan JG, Leder P. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell. 63: 185-94. PMID 1698555 DOI: 10.1016/0092-8674(90)90299-T  0.497
1990 Muller WJ, Lee FS, Dickson C, Peters G, Pattengale P, Leder P. The int-2 gene product acts as an epithelial growth factor in transgenic mice. The Embo Journal. 9: 907-13. PMID 1690126 DOI: 10.1002/J.1460-2075.1990.Tb08188.X  0.386
1989 Beier DR, Morton CC, Leder A, Wallace R, Leder P. Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15. Genomics. 4: 498-504. PMID 2744761 DOI: 10.1016/0888-7543(89)90272-3  0.572
1989 Sarid J, Benfey PN, Leder P. The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. The Journal of Biological Chemistry. 264: 1022-6. PMID 2642895  0.603
1989 Shimizu A, Kinashi T, Nussenzweig MC, Mizuta TR, Leder P, Honjo T. Molecular mechanism for immunoglobulin double-isotype expression. Cold Spring Harbor Symposia On Quantitative Biology. 54: 175-81. PMID 2639752 DOI: 10.1101/Sqb.1989.054.01.022  0.44
1989 Zeller R, Jackson-Grusby L, Leder P. The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation. Genes & Development. 3: 1481-92. PMID 2612902 DOI: 10.1101/Gad.3.10.1481  0.722
1989 Shimizu A, Nussenzweig MC, Mizuta TR, Leder P, Honjo T. Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. Proceedings of the National Academy of Sciences of the United States of America. 86: 8020-3. PMID 2510157 DOI: 10.1073/Pnas.86.20.8020  0.561
1989 Zaller R, Vogt T, Jackson-Grusby L, Leder P. The formin gene: A molecular link between apical extodermal ridge differentiation and anterior-posterior limb pattern formation Cell Differentiation and Development. 27: 169. DOI: 10.1016/0922-3371(89)90518-2  0.707
1988 Sarid J, Leder P. Sequence analysis of a yeast genomic DNA fragment sharing homology with the human c-myc gene. Nucleic Acids Research. 16: 4725. PMID 3288972 DOI: 10.1093/nar/16.10.4725  0.38
1988 Schmidt EV, Pattengale PK, Weir L, Leder P. Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model. Proceedings of the National Academy of Sciences of the United States of America. 85: 6047-51. PMID 3261863 DOI: 10.1073/Pnas.85.16.6047  0.385
1988 Nussenzweig MC, Schmidt EV, Shaw AC, Sinn E, Campos-Torres J, Mathey-Prevot B, Pattengale PK, Leder P. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature. 336: 446-50. PMID 3143076 DOI: 10.1038/336446A0  0.375
1988 Nussenzweig MC, Shaw AC, Sinn E, Campos-Torres J, Leder P. Allelic exclusion in transgenic mice carrying mutant human IgM genes. The Journal of Experimental Medicine. 167: 1969-74. PMID 3133444 DOI: 10.1084/Jem.167.6.1969  0.403
1988 Shimizu A, Tepler I, Benfey PN, Berenstein EH, Siraganian RP, Leder P. Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. Proceedings of the National Academy of Sciences of the United States of America. 85: 1907-11. PMID 2964640 DOI: 10.1073/Pnas.85.6.1907  0.707
1988 Flanagan JG, Leder P. neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation. Proceedings of the National Academy of Sciences of the United States of America. 85: 8057-61. PMID 2903500 DOI: 10.1073/Pnas.85.21.8057  0.523
1988 Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 54: 105-15. PMID 2898299 DOI: 10.1016/0092-8674(88)90184-5  0.332
1987 Chung J, Sussman DJ, Zeller R, Leder P. The c-myc gene encodes superimposed RNA polymerase II and III promoters. Cell. 51: 1001-8. PMID 3690658 DOI: 10.1016/0092-8674(87)90586-1  0.371
1987 Benfey PN, Yin FH, Leder P. Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. The Journal of Biological Chemistry. 262: 5377-84. PMID 3549719  0.62
1987 Sarid J, Halazonetis TD, Murphy W, Leder P. Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proceedings of the National Academy of Sciences of the United States of America. 84: 170-3. PMID 3467348 DOI: 10.1073/Pnas.84.1.170  0.394
1987 Nussenzweig MC, Shaw AC, Sinn E, Danner DB, Holmes KL, Morse HC, Leder P. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science (New York, N.Y.). 236: 816-9. PMID 3107126 DOI: 10.1126/science.3107126  0.391
1987 Swain JL, Stewart TA, Leder P. Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell. 50: 719-27. PMID 3040259 DOI: 10.1016/0092-8674(87)90330-8  0.306
1987 Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell. 49: 465-75. PMID 3032456 DOI: 10.1016/0092-8674(87)90449-1  0.319
1987 SWAIN J, STEWART T, LEDER P. Parental legacy determines methylation and myocardial expression of an autosomal fusion gene carried by a transgenic mouse Journal of Molecular and Cellular Cardiology. 19: S16-S16. DOI: 10.1016/S0022-2828(87)80671-5  0.331
1986 Murphy W, Sarid J, Taub R, Vasicek T, Battey J, Lenoir G, Leder P. A translocated human c-myc oncogene is altered in a conserved coding sequence. Proceedings of the National Academy of Sciences of the United States of America. 83: 2939-43. PMID 3517879 DOI: 10.1073/Pnas.83.9.2939  0.444
1986 Chung J, Sinn E, Reed RR, Leder P. Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 7918-22. PMID 3464006 DOI: 10.1073/Pnas.83.20.7918  0.637
1986 Weir L, Leder P. Structure and expression of a human subgroup II immunoglobulin kappa gene. Nucleic Acids Research. 14: 3957-70. PMID 3086847 DOI: 10.1093/nar/14.9.3957  0.457
1986 Pattengale P, Leder A, Kuo A, Stewart T, Leder P. Lymphohematopoietic and other malignant neoplasms occurring spontaneously in transgenic mice carrying and expressing MTV/myc fusion genes. Current Topics in Microbiology and Immunology. 132: 9-16. PMID 3024925 DOI: 10.1007/978-3-642-71562-4_2  0.322
1986 Leder A, Pattengale PK, Kuo A, Stewart TA, Leder P. Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell. 45: 485-95. PMID 3011271 DOI: 10.1016/0092-8674(86)90280-1  0.406
1986 Chang H, Dmitrovsky E, Hieter PA, Mitchell K, Leder P, Turoczi L, Kirsch IR, Hollis GF. Identification of three new Ig lambda-like genes in man. The Journal of Experimental Medicine. 163: 425-35. PMID 3003227 DOI: 10.1084/jem.163.2.425  0.633
1985 Leder A, Weir L, Leder P. Characterization, expression, and evolution of the mouse embryonic zeta-globin gene. Molecular and Cellular Biology. 5: 1025-33. PMID 4000117 DOI: 10.1128/Mcb.5.5.1025  0.484
1985 Danner D, Leder P. Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA. Proceedings of the National Academy of Sciences of the United States of America. 82: 8658-62. PMID 3936040 DOI: 10.1073/Pnas.82.24.8658  0.364
1985 Moulding C, Rapoport A, Goldman P, Battey J, Lenoir GM, Leder P. Structural analysis of both products of a reciprocal translocation between c-myc and immunoglobulin loci in Burkitt lymphoma. Nucleic Acids Research. 13: 2141-52. PMID 3923436 DOI: 10.1093/Nar/13.6.2141  0.372
1985 Hennighausen L, Siebenlist U, Danner D, Leder P, Rawlins D, Rosenfeld P, Kelly T. High-affinity binding site for a specific nuclear protein in the human IgM gene. Nature. 314: 289-92. PMID 3920528 DOI: 10.1038/314289a0  0.368
1985 Berliner N, Duby AD, Morton CC, Leder P, Seidman JG. Detection of a frequent restriction fragment length polymorphism in the human T cell antigen receptor beta chain locus. A potential diagnostic tool. The Journal of Clinical Investigation. 76: 1283-5. PMID 2995449 DOI: 10.1172/Jci112086  0.658
1985 Siebenlist U, Hennighausen L, Battey J, Leder P. Chromatin structure of the human c-myc oncogene: definition of regulatory regions and changes in Burkitt's lymphomas. Haematology and Blood Transfusion. 29: 261-5. PMID 2993113 DOI: 10.1007/978-3-642-70385-0_53  0.343
1984 Morton CC, Taub R, Diamond A, Lane MA, Cooper GM, Leder P. Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1. Science (New York, N.Y.). 223: 173-5. PMID 6691143 DOI: 10.1126/Science.6691143  0.374
1984 Bonner T, O'Brien SJ, Nash WG, Rapp UR, Morton CC, Leder P. The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science (New York, N.Y.). 223: 71-4. PMID 6691137 DOI: 10.1126/Science.6691137  0.387
1984 Stewart TA, Bellvé AR, Leder P. Transcription and promoter usage of the myc gene in normal somatic and spermatogenic cells. Science (New York, N.Y.). 226: 707-10. PMID 6494906 DOI: 10.1126/Science.6494906  0.383
1984 Stewart TA, Pattengale PK, Leder P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell. 38: 627-37. PMID 6488314 DOI: 10.1016/0092-8674(84)90257-5  0.406
1984 Persson H, Leder P. Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. Science (New York, N.Y.). 225: 718-21. PMID 6463648 DOI: 10.1126/Science.6463648  0.314
1984 Potter H, Weir L, Leder P. Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proceedings of the National Academy of Sciences of the United States of America. 81: 7161-5. PMID 6438633 DOI: 10.1073/Pnas.81.22.7161  0.443
1984 Siebenlist U, Hennighausen L, Battey J, Leder P. Chromatin structural changes in the putative regulatory region of c-myc accompany the translocation in a Burkitt lymphoma. Current Topics in Microbiology and Immunology. 113: 183-9. PMID 6434235 DOI: 10.1007/978-3-642-69860-6_31  0.357
1984 Persson H, Hennighausen L, Taub R, DeGrado W, Leder P. Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science (New York, N.Y.). 225: 687-93. PMID 6431612 DOI: 10.1126/Science.6431612  0.343
1984 Hollis GF, Mitchell KF, Battey J, Potter H, Taub R, Lenoir GM, Leder P. A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma. Nature. 307: 752-5. PMID 6422306 DOI: 10.1038/307752A0  0.397
1984 Mitchell KF, Battey J, Hollis GF, Moulding C, Taub R, Leder P. The effect of translocations on the cellular myc gene in Burkitt lymphomas. Journal of Cellular Physiology. Supplement. 3: 171-7. PMID 6378935 DOI: 10.1002/Jcp.1041210420  0.418
1984 Kelly K, Cochran B, Stiles C, Leder P. The regulation of c-myc by growth signals. Current Topics in Microbiology and Immunology. 113: 117-26. PMID 6332711 DOI: 10.1007/978-3-642-69860-6_22  0.315
1984 Taub R, Kelly K, Battey J, Latt S, Lenoir GM, Tantravahi U, Tu Z, Leder P. A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma. Cell. 37: 511-20. PMID 6327071 DOI: 10.1016/0092-8674(84)90381-7  0.387
1984 Siebenlist U, Hennighausen L, Battey J, Leder P. Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell. 37: 381-91. PMID 6327064 DOI: 10.1016/0092-8674(84)90368-4  0.434
1984 Taub R, Moulding C, Battey J, Murphy W, Vasicek T, Lenoir GM, Leder P. Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells. Cell. 36: 339-48. PMID 6319017 DOI: 10.1016/0092-8674(84)90227-7  0.404
1984 Armelin HA, Armelin MC, Kelly K, Stewart T, Leder P, Cochran BH, Stiles CD. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature. 310: 655-60. PMID 6088986 DOI: 10.1038/310655A0  0.341
1983 Kelly K, Cochran BH, Stiles CD, Leder P. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell. 35: 603-10. PMID 6606489 DOI: 10.1016/0092-8674(83)90092-2  0.331
1983 Battey J, Moulding C, Taub R, Murphy W, Stewart T, Potter H, Lenoir G, Leder P. The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Cell. 34: 779-87. PMID 6414718 DOI: 10.1016/0092-8674(83)90534-2  0.435
1983 Waldmann TA, Korsmeyer SJ, Hieter PA, Ravetch JV, Broder S, Leder P. Regulation of the humoral immune response: from immunoglobulin genes to regulatory T cell networks. Federation Proceedings. 42: 2498-503. PMID 6404657  0.546
1983 Korsmeyer SJ, Arnold A, Bakhshi A, Ravetch JV, Siebenlist U, Hieter PA, Sharrow SO, LeBien TW, Kersey JH, Poplack DG, Leder P, Waldmann TA. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. The Journal of Clinical Investigation. 71: 301-13. PMID 6401769 DOI: 10.1172/Jci110770  0.743
1983 Leder P, Battey J, Lenoir G, Moulding C, Murphy W, Potter H, Stewart T, Taub R. Translocations among antibody genes in human cancer. Science (New York, N.Y.). 222: 765-71. PMID 6356357 DOI: 10.1126/Science.6356357  0.434
1983 Emorine L, Kuehl M, Weir L, Leder P, Max EE. A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element. Nature. 304: 447-9. PMID 6308460 DOI: 10.1038/304447A0  0.406
1983 Taub RA, Hollis GF, Hieter PA, Korsmeyer S, Waldmann TA, Leder P. Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature. 304: 172-4. PMID 6306474 DOI: 10.1038/304172A0  0.727
1983 Leder P. Gene Evolution v Special Creation-Reply Jama: the Journal of the American Medical Association. 250: 32. DOI: 10.1001/jama.1983.03340010017011  0.308
1982 Talkington CA, Leder P. Rescuing the in vitro function of a globin pseudogene promoter. Nature. 298: 192-5. PMID 7088172 DOI: 10.1038/298192A0  0.368
1982 Lueders K, Leder A, Leder P, Kuff E. Association between a transposed alpha-globin pseudogene and retrovirus-like elements in the BALB/c mouse genome. Nature. 295: 426-8. PMID 7057906 DOI: 10.1038/295426A0  0.401
1982 Battey J, Max EE, McBride WO, Swan D, Leder P. A processed human immunoglobulin epsilon gene has moved to chromosome 9. Proceedings of the National Academy of Sciences of the United States of America. 79: 5956-60. PMID 6964396 DOI: 10.1073/Pnas.79.19.5956  0.425
1982 McBride OW, Battey J, Hollis GF, Swan DC, Siebenlist U, Leder P. Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14. Nucleic Acids Research. 10: 8155-70. PMID 6819544 DOI: 10.1093/Nar/10.24.8155  0.363
1982 Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 7837-41. PMID 6818551 DOI: 10.1073/Pnas.79.24.7837  0.391
1982 Korsmeyer SJ, Hieter PA, Sharrow SO, Goldman CK, Leder P, Waldmann TA. Normal human B cells display ordered light chain gene rearrangements and deletions. The Journal of Experimental Medicine. 156: 975-85. PMID 6818320 DOI: 10.1084/Jem.156.4.975  0.755
1982 McBride OW, Hieter PA, Hollis GF, Swan D, Otey MC, Leder P. Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. The Journal of Experimental Medicine. 155: 1480-90. PMID 6802926 DOI: 10.1084/jem.155.5.1480  0.619
1982 Kirsch IR, Morton CC, Nakahara K, Leder P. Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science (New York, N.Y.). 216: 301-3. PMID 6801764 DOI: 10.1126/Science.6801764  0.361
1982 Hollis GF, Hieter PA, McBride OW, Swan D, Leder P. Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing. Nature. 296: 321-5. PMID 6801526 DOI: 10.1038/296321a0  0.546
1982 Max EE, Battey J, Ney R, Kirsch IR, Leder P. Duplication and deletion in the human immunoglobulin epsilon genes. Cell. 29: 691-9. PMID 6288268 DOI: 10.1016/0092-8674(82)90185-4  0.444
1982 Leder P. Mechanisms of gene evolution. Jama. 248: 1582-91. PMID 6287053 DOI: 10.1001/Jama.1982.03330130030021  0.334
1982 Hieter PA, Maizel JV, Leder P. Evolution of human immunoglobulin kappa J region genes. The Journal of Biological Chemistry. 257: 1516-22. PMID 6276389  0.592
1981 Siebenlist U, Ravetch JV, Korsmeyer S, Waldmann T, Leder P. Human immunoglobulin D segments encoded in tandem multigenic families. Nature. 294: 631-5. PMID 7312051 DOI: 10.1038/294631A0  0.637
1981 Kwan SP, Max EE, Seidman JG, Leder P, Scharff MD. Two kappa immunoglobulin genes are expressed in the myeloma S107. Cell. 26: 57-66. PMID 6799208 DOI: 10.1016/0092-8674(81)90033-7  0.446
1981 Kirsch IR, Ravetch JV, Kwan SP, Max EE, Ney RL, Leder P. Multiple immunoglobulin switch region homologies outside the heavy chain constant region locus. Nature. 293: 585-7. PMID 6793874 DOI: 10.1038/293585A0  0.414
1981 Leder P, Max EE, Seidman JG, Kwan SP, Scharff M, Nau M, Norman B. Recombination events that activate, diversify, and delete immunoglobulin genes. Cold Spring Harbor Symposia On Quantitative Biology. 45: 859-65. PMID 6790218 DOI: 10.1101/Sqb.1981.045.01.103  0.566
1981 Kwan SP, Rudikoff S, Seidman JG, Leder P, Scharff MD. Nucleic acid and protein sequences of phosphocholine-binding light chains. The Journal of Experimental Medicine. 153: 1366-70. PMID 6788890 DOI: 10.1084/Jem.153.5.1366  0.542
1981 Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P. Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature. 290: 368-72. PMID 6783958 DOI: 10.1038/290368A0  0.719
1981 Korsmeyer SJ, Hieter PA, Ravetch JV, Poplack DG, Waldmann TA, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 7096-100. PMID 6273911 DOI: 10.1073/Pnas.78.11.7096  0.751
1981 Hieter PA, Hollis GF, Korsmeyer SJ, Waldmann TA, Leder P. Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature. 294: 536-40. PMID 6273747 DOI: 10.1038/294536A0  0.74
1981 Leder P, Konkel DA, Nishiuoka Y, Leder A, Hamer DH, Kaehler M. The organization and evolution of cloned globin genes. Progress in Clinical and Biological Research. 45: 51-66. PMID 6264492  0.337
1981 Leder A, Swan D, Ruddle F, D'Eustachio P, Leder P. Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature. 293: 196-200. PMID 6168916 DOI: 10.1038/293196A0  0.409
1981 Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell. 27: 583-91. PMID 6101209 DOI: 10.1016/0092-8674(81)90400-1  0.669
1981 Leder P, Heiter P, Kirsch I, Korsmeyer S, Ravetch J, Waldmann T. HUMAN IMMUNOGLOBULIN GENES: THE ONTOGENY OF SOMATIC REARRANGEMENTS Biochemical Society Transactions. 9: 82P-82P. DOI: 10.1042/Bst009082P  0.627
1980 Leder P, Hansen JN, Konkel D, Leder A, Nishioka Y, Talkington C. Mouse globin system: a functional and evolutionary analysis. Science (New York, N.Y.). 209: 1336-42. PMID 7414319 DOI: 10.1126/Science.7414319  0.435
1980 Talkington CA, Nishioka Y, Leder P. In vitro transcription of normal, mutant, and truncated mouse alpha-globin genes. Proceedings of the National Academy of Sciences of the United States of America. 77: 7132-6. PMID 6938959 DOI: 10.1073/Pnas.77.12.7132  0.353
1980 Nishioka Y, Leder A, Leder P. Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences. Proceedings of the National Academy of Sciences of the United States of America. 77: 2806-9. PMID 6930668 DOI: 10.1073/Pnas.77.5.2806  0.374
1980 Ravetch JV, Kirsch IR, Leder P. Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes. Proceedings of the National Academy of Sciences of the United States of America. 77: 6734-8. PMID 6779282 DOI: 10.1073/Pnas.77.11.6734  0.417
1980 Seidman JG, Nau MM, Norman B, Kwan SP, Scharff M, Leder P. Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments. Proceedings of the National Academy of Sciences of the United States of America. 77: 6022-6. PMID 6777777 DOI: 10.1073/Pnas.77.10.6022  0.575
1980 Max EE, Seidman JG, Miller H, Leder P. Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene. Cell. 21: 793-9. PMID 6777049 DOI: 10.1016/0092-8674(80)90442-0  0.416
1980 Hieter PA, Max EE, Seidman JG, Maizel JV, Leder P. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell. 22: 197-207. PMID 6775818 DOI: 10.1016/0092-8674(80)90168-3  0.648
1980 Seidman JG, Leder P. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events. Nature. 286: 779-83. PMID 6772973 DOI: 10.1038/286779a0  0.53
1980 Obata M, Yamawaki-Kataoka Y, Takahashi N, Kataoka T, Shimizu A, Mano Y, Seidman JG, Peterlin BM, Leder P, Honjo T. Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid. Gene. 9: 87-97. PMID 6769752 DOI: 10.1016/0378-1119(80)90168-7  0.613
1980 Perry RP, Kelley DE, Coleclough C, Seidman JG, Leder P, Tonegawa S, Matthyssens G, Weigert M. Transcription of mouse kappa chain genes: implications for allelic exclusion. Proceedings of the National Academy of Sciences of the United States of America. 77: 1937-41. PMID 6769117 DOI: 10.1073/Pnas.77.4.1937  0.57
1980 Hamer DH, Kaehler M, Leder P. A mouse globin gene promoter is functional in SV40. Cell. 21: 697-708. PMID 6254665 DOI: 10.1016/0092-8674(80)90433-X  0.43
1980 Leder P, Konkel DA, Nishioka Y, Leder A, Hamer DH, Kaehler M. The organization and evolution of cloned globin genes. Recent Progress in Hormone Research. 36: 241-60. PMID 6158075 DOI: 10.1016/B978-0-12-571136-4.50013-9  0.44
1979 Konkel DA, Maizel JV, Leder P. The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes. Cell. 18: 865-73. PMID 519759 DOI: 10.1016/0092-8674(79)90138-7  0.339
1979 Hamer DH, Leder P. Splicing and the formation of stable RNA. Cell. 18: 1299-302. PMID 229971 DOI: 10.1016/0092-8674(79)90240-X  0.323
1979 Max EE, Seidman JG, Leder P. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proceedings of the National Academy of Sciences of the United States of America. 76: 3450-4. PMID 115000 DOI: 10.1073/pnas.76.7.3450  0.571
1979 Seidman JG, Max EE, Leder P. A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature. 280: 370-5. PMID 111146 DOI: 10.1038/280370A0  0.447
1978 Polsky F, Edgell MH, Seidman JG, Leder P. High capacity gel preparative electrophoresis for purification of fragments of genomic DNA. Analytical Biochemistry. 87: 397-410. PMID 686360 DOI: 10.1016/0003-2697(78)90689-9  0.455
1978 Konkel DA, Tilghman SM, Leder P. The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell. 15: 1125-32. PMID 569555 DOI: 10.1016/0092-8674(78)90040-5  0.403
1978 Seidman JG, Edgell MH, Leder P. Immunoglobulin light-chain structural gene sequences cloned in a bacterial plasmid. Nature. 271: 582-5. PMID 414143 DOI: 10.1038/271582A0  0.377
1978 Leder A, Miller HI, Hamer DH, Seidman JG, Norman B, Sullivan M, Leder P. Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. Proceedings of the National Academy of Sciences of the United States of America. 75: 6187-91. PMID 282635 DOI: 10.1073/pnas.75.12.6187  0.552
1978 Seidman JG, Leder A, Edgell MH, Polsky F, Tilghman SM, Tiemeier DC, Leder P. Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proceedings of the National Academy of Sciences of the United States of America. 75: 3881-5. PMID 279004 DOI: 10.1073/Pnas.75.8.3881  0.524
1978 Leder P, Tilghman SM, Tiemeier DC, Polsky FI, Seidman JG, Edgell MH, Enquist LW, Leder A, Norman B. The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda. Cold Spring Harbor Symposia On Quantitative Biology. 42: 915-20. PMID 277326 DOI: 10.1101/Sqb.1978.042.01.093  0.517
1978 Tilghman SM, Curtis PJ, Tiemeier DC, Leder P, Weissmann C. The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proceedings of the National Academy of Sciences of the United States of America. 75: 1309-13. PMID 274720 DOI: 10.1073/pnas.75.3.1309  0.339
1978 Tilghman SM, Tiemeier DC, Seidman JG, Peterlin BM, Sullivan M, Maizel JV, Leder P. Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 75: 725-9. PMID 273235 DOI: 10.1073/Pnas.75.2.725  0.543
1978 Seidman JG, Leder P. The arrangement and rearrangement of antibody genes. Nature. 276: 790-5. PMID 103004 DOI: 10.1038/276790a0  0.581
1978 Seidman JG, Leder A, Nau M, Norman B, Leder P. Antibody diversity. Science (New York, N.Y.). 202: 11-7. PMID 99815 DOI: 10.1126/science.99815  0.548
1977 Tiemeier DC, Tilghman SM, Leder P. Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene. 2: 173-91. PMID 608592 DOI: 10.1016/0378-1119(77)90016-6  0.386
1977 Leder P, Honjo T, Seidman J, Swan D. Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model. Cold Spring Harbor Symposia On Quantitative Biology. 41: 855-62. PMID 408082 DOI: 10.1101/Sqb.1977.041.01.095  0.627
1977 Leder P, Tiemeier D, Enquist L. EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system. Science (New York, N.Y.). 196: 175-7. PMID 322278 DOI: 10.1126/Science.322278  0.341
1977 Tilghman SM, Tiemeier DC, Polsky F, Edgell MH, Seidman JG, Leder A, Enquist LW, Norman B, Leder P. Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proceedings of the National Academy of Sciences of the United States of America. 74: 4406-10. PMID 270684 DOI: 10.1073/Pnas.74.10.4406  0.56
1976 Honjo T, Swan D, Packman S, Polsky F, Leder P. Purification and translation of an immunoglobulin lambda chain messenger RNA from mouse myeloma. Biochemistry. 15: 2775-9. PMID 59605 DOI: 10.1021/Bi00658A011  0.425
1975 Ross J, Ikawa Y, Gielen J, Packman S, Leder P. Induction of globin mRNA in Friend leukemia virus-infected cells and its presence in viral 60S RNA. Bibliotheca Haematologica. 205-20. PMID 1172437 DOI: 10.1159/000397535  0.353
1975 Leder A, Orkin S, Leder P. Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Science (New York, N.Y.). 190: 893-4. PMID 1059262 DOI: 10.1126/Science.1059262  0.517
1975 Orkin SH, Harosi FI, Leder P. Differentiation in erythroleukemic cells and their somatic hybrids Proceedings of the National Academy of Sciences of the United States of America. 72: 98-102. PMID 164031 DOI: 10.1073/Pnas.72.1.98  0.528
1974 Leder P, Honjo T, Packman S, Swan D, Nau M, Norman B. The organization and diversity of immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 71: 5109-15. PMID 4531042 DOI: 10.1073/Pnas.71.12.5109  0.557
1974 Ross J, Gielen J, Packman S, Ikawa Y, Leder P. Globin gene expression in cultured erythroleukemic cells. Journal of Molecular Biology. 87: 697-714. PMID 4530120 DOI: 10.1016/0022-2836(74)90079-5  0.404
1974 Honjo T, Packman S, Swan D, Nau M, Leder P. Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. Proceedings of the National Academy of Sciences of the United States of America. 71: 3659-63. PMID 4215083 DOI: 10.1073/Pnas.71.9.3659  0.57
1974 Venetianer P, Leder P. Enzymatic synthesis of solid phase-bound DNA sequences corresponding to specific mammalian genes. Proceedings of the National Academy of Sciences of the United States of America. 71: 3892-5. PMID 4139705 DOI: 10.1073/Pnas.71.10.3892  0.302
1974 Aviv H, Packman S, Ross J, Swan D, Gielen J, Leder P. DNA complementary to globin and immunoglobulin mRNA: a probe to study gene expression. Advances in Experimental Medicine and Biology. 44: 141-52. PMID 4135152 DOI: 10.1007/978-1-4684-3246-6_11  0.335
1974 Leder P, Ross J, Gielen J, Packman S, Ikawa Y, Aviv H, Swan D. Regulated expression of mammalian genes: globin and immunoglobulin as model systems. Cold Spring Harbor Symposia On Quantitative Biology. 38: 753-61. PMID 4133990 DOI: 10.1101/Sqb.1974.038.01.080  0.352
1973 Ross J, Aviv H, Leder P. Characterization of synthetic rabbit globin DNA. Archives of Biochemistry and Biophysics. 158: 494-502. PMID 4131387 DOI: 10.1016/0003-9861(73)90541-9  0.335
1972 Packman S, Aviv H, Ross J, Leder P. A comparison of globin genes in duck reticulocytes and liver cells. Biochemical and Biophysical Research Communications. 49: 813-9. PMID 4638756 DOI: 10.1016/0006-291X(72)90483-4  0.403
1972 Ross J, Ikawa Y, Leder P. Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells. Proceedings of the National Academy of Sciences of the United States of America. 69: 3620-3. PMID 4509323 DOI: 10.1073/Pnas.69.12.3620  0.356
1972 Ross J, Aviv H, Scolnick E, Leder P. In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proceedings of the National Academy of Sciences of the United States of America. 69: 264-8. PMID 4333043 DOI: 10.1073/Pnas.69.1.264  0.309
1970 Erbe RW, Nau MM, Leder P. Translation and translocation of defined RNA messengers. Journal of Molecular Biology. 39: 441-60. PMID 4902905 DOI: 10.1016/0022-2836(69)90137-5  0.307
1969 Livingston DM, Leder P. Deformylation and protein biosynthesis. Biochemistry. 8: 435-43. PMID 4887858 DOI: 10.1021/Bi00829A059  0.389
1965 TRUPIN JS, ROTTMAN FM, BRIMACOMBE RL, LEDER P, BERNFIELD MR, NIRENBERG MW. RNA CODEWORDS AND PROTEIN SYNTHESIS, VI. ON THE NUCLEOTIDE SEQUENCES OF DEGENERATE CODEWORD SETS FOR ISOLEUCINE, TYROSINE, ASPARAGINE, AND LYSINE. Proceedings of the National Academy of Sciences of the United States of America. 53: 807-11. PMID 14324538  0.648
1965 Nirenberg M, Leder P, Bernfield M, Brimacombe R, Trupin J, Rottman F, O'Neal C. RNA codewords and protein synthesis, VII. On the general nature of the RNA code. Proceedings of the National Academy of Sciences of the United States of America. 53: 1161-8. PMID 5330357 DOI: 10.1073/Pnas.53.5.1161  0.646
1965 Brimacombe R, Trupin J, Nirenberg M, Leder P, Bernfield M, Jaouni T. RNA codewords and protein synthesis, 8. Nucleotide sequences of synonym codons for arginine, valine, cysteine, and alanine. Proceedings of the National Academy of Sciences of the United States of America. 54: 954-60. PMID 5324401 DOI: 10.1073/Pnas.54.3.954  0.65
1964 LEDER P, NIRENBERG MW. RNA CODEWORDS AND PROTEIN SYNTHESIS, 3. ON THE NUCLEOTIDE SEQUENCE OF A CYSTEINE AND A LEUCINE RNA CODEWORD. Proceedings of the National Academy of Sciences of the United States of America. 52: 1521-9. PMID 14243527  0.463
1964 LEDER P, NIRENBERG M. RNA CODEWORDS AND PROTEIN SYNTHESIS. II. NUCLEOTIDE SEQUENCE OF A VALINE RNA CODEWORD. Proceedings of the National Academy of Sciences of the United States of America. 52: 420-7. PMID 14206609  0.461
1964 NIRENBERG M, LEDER P. RNA CODEWORDS AND PROTEIN SYNTHESIS. THE EFFECT OF TRINUCLEOTIDES UPON THE BINDING OF SRNA TO RIBOSOMES. Science (New York, N.Y.). 145: 1399-407. PMID 14172630 DOI: 10.1126/science.145.3639.1399  0.493
1963 LEDER P, CLARK BF, SLY WS, PESTKA S, NIRENBERG MW. CELL-FREE PEPTIDE SYNTHESIS DEPENDENT UPON SYNTHETIC OLIGODEOXYNUCLEOTIDES. Proceedings of the National Academy of Sciences of the United States of America. 50: 1135-43. PMID 14096189 DOI: 10.1073/Pnas.50.6.1135  0.496
1963 Nirenberg MW, Jones OW, Leder P, Clark BFC, Sly WS, Pestka S. On the Coding of Genetic Information Cold Spring Harbor Symposia On Quantitative Biology. 28: 549-557. DOI: 10.1101/SQB.1963.028.01.074  0.418
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