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Jeannie T. Lee - Publications

Affiliations: 
Molecular Biology Massachusetts General Hospital, Boston, MA 
Area:
X-Chromosome Inactivation
Website:
http://genetics.med.harvard.edu/faculty/lee
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159 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wei C, Kesner B, Yin H, Lee JT. Imprinted X chromosome inactivation at the gamete-to-embryo transition. Molecular Cell. PMID 38458200 DOI: 10.1016/j.molcel.2024.02.013  0.482
2023 Nickbarg EB, Spencer KB, Mortison JD, Lee JT. Targeting RNA with small molecules: Lessons learned from Xist RNA. Rna (New York, N.Y.). PMID 36725318 DOI: 10.1261/rna.079523.122  0.343
2023 Generoso SF, Neguembor MV, Hershberg EA, Sadreyev RI, Kurimoto K, Yabuta Y, Ricci R, Audergon P, Bauer M, Saitou M, Hochedlinger K, Beliveau BJ, Cosma MP, Lee JT, Payer B. Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming. Proceedings of the National Academy of Sciences of the United States of America. 120: e2213810120. PMID 36669113 DOI: 10.1073/pnas.2213810120  0.509
2023 Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL, Chen R, Dean C, Dinger ME, Fitzgerald KA, Gingeras TR, Guttman M, Hirose T, Huarte M, Johnson R, ... ... Lee JT, et al. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nature Reviews. Molecular Cell Biology. PMID 36596869 DOI: 10.1038/s41580-022-00566-8  0.305
2022 Aguilar R, Spencer KB, Kesner B, Rizvi NF, Badmalia MD, Mrozowich T, Mortison JD, Rivera C, Smith GF, Burchard J, Dandliker PJ, Patel TR, Nickbarg EB, Lee JT. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature. 604: 160-166. PMID 35355011 DOI: 10.1038/s41586-022-04537-z  0.38
2022 Grimm NB, Lee JT. Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome. Trends in Genetics : Tig. PMID 35248405 DOI: 10.1016/j.tig.2022.01.007  0.465
2021 Oh HJ, Aguilar R, Kesner B, Lee HG, Kriz AJ, Chu HP, Lee JT. Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops. Cell. PMID 34856126 DOI: 10.1016/j.cell.2021.11.012  0.329
2021 Lappala A, Wang CY, Kriz A, Michalk H, Tan K, Lee JT, Sanbonmatsu KY. Four-dimensional chromosome reconstruction elucidates the spatiotemporal reorganization of the mammalian X chromosome. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34645712 DOI: 10.1073/pnas.2107092118  0.423
2021 Szanto A, Aguilar R, Kesner B, Blum R, Wang D, Cifuentes-Rojas C, Del Rosario BC, Kis-Toth K, Lee JT. A disproportionate impact of G9a methyltransferase deficiency on the X chromosome. Genes & Development. 35: 1035-1054. PMID 34168040 DOI: 10.1101/gad.337592.120  0.325
2021 Yin H, Wei C, Lee JT. Revisiting the consequences of deleting the X inactivation center. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34161282 DOI: 10.1073/pnas.2102683118  0.519
2021 Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT. Xist Repeat A contributes to early recruitment of Polycomb complexes during X-chromosome inactivation. Developmental Cell. 56: 1236-1237. PMID 33945784 DOI: 10.1016/j.devcel.2021.04.007  0.426
2021 Kriz AJ, Colognori D, Sunwoo H, Nabet B, Lee JT. Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation. Molecular Cell. PMID 33725485 DOI: 10.1016/j.molcel.2021.02.031  0.487
2021 Rosenberg M, Blum R, Kesner B, Aeby E, Garant JM, Szanto A, Lee JT. Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation. Nature Structural & Molecular Biology. PMID 33398172 DOI: 10.1038/s41594-020-00535-9  0.328
2020 Aeby E, Lee HG, Lee YW, Kriz A, Del Rosario BC, Oh HJ, Boukhali M, Haas W, Lee JT. Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover. Nature Cell Biology. PMID 32807903 DOI: 10.1038/S41556-020-0558-0  0.561
2020 Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT. Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. Developmental Cell. PMID 32531209 DOI: 10.1016/J.Devcel.2020.05.021  0.546
2020 Kadota S, Ou J, Shi Y, Lee JT, Sun J, Yildirim E. Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Nature Communications. 11: 2606. PMID 32451376 DOI: 10.1038/S41467-020-16394-3  0.396
2020 Yang L, Yildirim E, Kirby JE, Press W, Lee JT. Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut. Proceedings of the National Academy of Sciences of the United States of America. PMID 32041873 DOI: 10.1073/Pnas.1917203117  0.453
2019 Oh HJ, Lee JT. Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on "Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence" by Karner et al. (2019). Journal of Molecular Biology. PMID 31892474 DOI: 10.1016/J.Jmb.2019.11.011  0.426
2019 Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT. B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871160 DOI: 10.1073/Pnas.1917190117  0.39
2019 Lewandowski JP, Lee JC, Hwang T, Sunwoo H, Goldstein JM, Groff AF, Chang NP, Mallard W, Williams A, Henao-Meija J, Flavell RA, Lee JT, Gerhardinger C, Wagers AJ, Rinn JL. The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis. Nature Communications. 10: 5137. PMID 31723143 DOI: 10.1038/S41467-019-12970-4  0.499
2019 Wang CY, Brand H, Shaw ND, Talkowski ME, Lee JT. Role of the Chromosome Architectural Factor SMCHD1 in X Chromosome Inactivation, Gene Regulation, and Disease in Humans. Genetics. PMID 31420322 DOI: 10.1534/Genetics.119.302600  0.479
2019 Wang CY, Colognori D, Sunwoo H, Wang D, Lee JT. PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments. Nature Communications. 10: 2950. PMID 31270318 DOI: 10.1038/S41467-019-10755-3  0.46
2019 Colognori D, Sunwoo H, Kriz AJ, Wang CY, Lee JT. Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. Molecular Cell. PMID 30827740 DOI: 10.1016/J.Molcel.2019.01.015  0.565
2019 Lee HJ, Gopalappa R, Sunwoo H, Choi SW, Ramakrishna S, Lee JT, Kim HH, Nam JW. En bloc and segmental deletions of human XIST reveal X chromosome inactivation-involving RNA elements. Nucleic Acids Research. PMID 30783652 DOI: 10.1093/Nar/Gkz109  0.553
2019 Del Rosario BC, Kriz AJ, Del Rosario AM, Anselmo A, Frye CJ, White FM, Sadreyev RI, Lee JT. Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition. Elife. 8. PMID 30676316 DOI: 10.7554/Elife.42341  0.314
2019 Jégu T, Blum R, Cochrane JC, Yang L, Wang CY, Gilles ME, Colognori D, Szanto A, Marr SK, Kingston RE, Lee JT. Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome. Nature Structural & Molecular Biology. PMID 30664740 DOI: 10.1038/S41594-018-0176-8  0.538
2019 Lee JT. Decision letter: In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation Elife. DOI: 10.7554/Elife.47214.018  0.315
2018 Froberg JE, Pinter SF, Kriz AJ, Jégu T, Lee JT. Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape. Nature Communications. 9: 5004. PMID 30479398 DOI: 10.1038/S41467-018-07446-W  0.554
2018 Saltzman AL, Soo MW, Aram R, Lee JT. Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in . Genetics. PMID 30185429 DOI: 10.1534/Genetics.118.301518  0.347
2018 Carrette LLG, Blum R, Ma W, Kelleher RJ, Lee JT. Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. Proceedings of the National Academy of Sciences of the United States of America. PMID 30038001 DOI: 10.1073/Pnas.1800931115  0.43
2018 Matoba S, Wang H, Jiang L, Lu F, Iwabuchi KA, Wu X, Inoue K, Yang L, Press W, Lee JT, Ogura A, Shen L, Zhang Y. Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. Cell Stem Cell. PMID 30033120 DOI: 10.1016/J.Stem.2018.06.008  0.356
2018 Wang CY, Jégu T, Chu HP, Oh HJ, Lee JT. SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X. Cell. PMID 29887375 DOI: 10.1016/J.Cell.2018.05.007  0.487
2017 Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT. A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. Proceedings of the National Academy of Sciences of the United States of America. PMID 29282321 DOI: 10.1073/Pnas.1715124115  0.504
2017 Del Rosario BC, Del Rosario AM, Anselmo A, Wang PI, Sadreyev RI, Lee JT. Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation. Developmental Cell. PMID 29107559 DOI: 10.1016/J.Devcel.2017.09.027  0.488
2017 Rosenberg M, Blum R, Kesner B, Maier VK, Szanto A, Lee JT. Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression. Cell Systems. 5: 368-385.e15. PMID 29073373 DOI: 10.1016/J.Cels.2017.09.014  0.417
2017 Sunwoo H, Colognori D, Froberg JE, Jeon Y, Lee JT. Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1). Proceedings of the National Academy of Sciences of the United States of America. PMID 28923964 DOI: 10.1073/Pnas.1711206114  0.548
2017 Savol AJ, Wang PI, Jeon Y, Colognori D, Yildirim E, Pinter SF, Payer B, Lee JT, Sadreyev RI. Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. Plos One. 12: e0182568. PMID 28796844 DOI: 10.1371/Journal.Pone.0182568  0.425
2017 Chu HP, Froberg JE, Kesner B, Oh HJ, Ji F, Sadreyev R, Pinter SF, Lee JT. PAR-TERRA directs homologous sex chromosome pairing. Nature Structural & Molecular Biology. PMID 28692038 DOI: 10.1038/Nsmb.3432  0.569
2017 Chu HP, Cifuentes-Rojas C, Kesner B, Aeby E, Lee HG, Wei C, Oh HJ, Boukhali M, Haas W, Lee JT. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell. 170: 86-101.e16. PMID 28666128 DOI: 10.1016/J.Cell.2017.06.017  0.449
2017 Wang CY, Froberg JE, Blum R, Jeon Y, Lee JT. Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing". Science (New York, N.Y.). 356. PMID 28619887 DOI: 10.1126/Science.Aal4976  0.52
2017 Jégu T, Aeby E, Lee JT. The X chromosome in space. Nature Reviews. Genetics. PMID 28479596 DOI: 10.1038/Nrg.2017.17  0.565
2017 Kundu S, Ji F, Sunwoo H, Jain G, Lee JT, Sadreyev RI, Dekker J, Kingston RE. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Molecular Cell. 65: 432-446.e5. PMID 28157505 DOI: 10.1016/J.Molcel.2017.01.009  0.337
2017 Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28143937 DOI: 10.1073/Pnas.1621356114  0.587
2016 Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proceedings of the National Academy of Sciences of the United States of America. 113: 14366-14371. PMID 28182563 DOI: 10.1073/Pnas.1617597113  0.459
2016 Zovoilis A, Cifuentes-Rojas C, Chu HP, Hernandez AJ, Lee JT. Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell. 167: 1788-1802.e13. PMID 27984727 DOI: 10.1016/J.Cell.2016.11.041  0.373
2016 Yang L, Kirby JE, Sunwoo H, Lee JT. Female mice lacking Xist RNA show partial dosage compensation and survive to term. Genes & Development. 30: 1747-60. PMID 27542829 DOI: 10.1101/Gad.281162.116  0.545
2015 Sun S, Payer B, Namekawa S, An JY, Press W, Catalan-Dibene J, Sunwoo H, Lee JT. Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proceedings of the National Academy of Sciences of the United States of America. PMID 26489649 DOI: 10.1073/Pnas.1519528112  0.553
2015 Sunwoo H, Wu JY, Lee JT. The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E4216-25. PMID 26195790 DOI: 10.1073/Pnas.1503690112  0.504
2015 Minajigi A, Froberg JE, Wei C, Sunwoo H, Kesner B, Colognori D, Lessing D, Payer B, Boukhali M, Haas W, Lee JT. Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation. Science (New York, N.Y.). 349. PMID 26089354 DOI: 10.1126/Science.Aab2276  0.576
2015 Beliveau BJ, Boettiger AN, Avendaño MS, Jungmann R, McCole RB, Joyce EF, Kim-Kiselak C, Bantignies F, Fonseka CY, Erceg J, Hannan MA, Hoang HG, Colognori D, Lee JT, Shih WM, et al. Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes. Nature Communications. 6: 7147. PMID 25962338 DOI: 10.1038/Ncomms8147  0.372
2015 Pinter SF, Colognori D, Beliveau BJ, Sadreyev RI, Payer B, Yildirim E, Wu CT, Lee JT. Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. Genetics. 200: 537-49. PMID 25858912 DOI: 10.1534/Genetics.115.176263  0.397
2015 Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto A, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Jaffe JD, Mertins P, Lee JT. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Molecular & Cellular Proteomics : McP. 14: 1435-46. PMID 25680957 DOI: 10.1074/Mcp.M114.044586  0.309
2015 Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Molecular Cell. 57: 552-8. PMID 25601759 DOI: 10.1016/J.Molcel.2014.12.017  0.411
2015 Kung JT, Kesner B, An JY, Ahn JY, Cifuentes-Rojas C, Colognori D, Jeon Y, Szanto A, del Rosario BC, Pinter SF, Erwin JA, Lee JT. Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF. Molecular Cell. 57: 361-75. PMID 25578877 DOI: 10.1016/J.Molcel.2014.12.006  0.8
2015 Creech AL, Taylor JE, Maier VK, Wu X, Feeney CM, Udeshi ND, Peach SE, Boehm JS, Lee JT, Carr SA, Jaffe JD. Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry. Methods (San Diego, Calif.). 72: 57-64. PMID 25448295 DOI: 10.1016/J.Ymeth.2014.10.033  0.307
2014 Sarma K, Cifuentes-Rojas C, Ergun A, Del Rosario A, Jeon Y, White F, Sadreyev R, Lee JT. ATRX directs binding of PRC2 to Xist RNA and Polycomb targets. Cell. 159: 869-83. PMID 25417162 DOI: 10.1016/J.Cell.2014.10.019  0.519
2014 Payer B, Lee JT. Coupling of X-chromosome reactivation with the pluripotent stem cell state. Rna Biology. 11: 798-807. PMID 25137047 DOI: 10.4161/Rna.29779  0.633
2014 Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH. BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. The Journal of Cell Biology. 205: 663-75. PMID 24914237 DOI: 10.1083/Jcb.201311050  0.511
2014 Cifuentes-Rojas C, Hernandez AJ, Sarma K, Lee JT. Regulatory interactions between RNA and polycomb repressive complex 2. Molecular Cell. 55: 171-85. PMID 24882207 DOI: 10.1016/J.Molcel.2014.05.009  0.426
2014 Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell. 54: 777-90. PMID 24857549 DOI: 10.1016/J.Molcel.2014.04.025  0.302
2014 Yang L, Froberg JE, Lee JT. Long noncoding RNAs: fresh perspectives into the RNA world. Trends in Biochemical Sciences. 39: 35-43. PMID 24290031 DOI: 10.1016/J.Tibs.2013.10.002  0.408
2013 Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT. Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Molecular Cell. 52: 805-18. PMID 24268575 DOI: 10.1016/J.Molcel.2013.10.023  0.61
2013 Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE, Lee JT. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. 504: 465-9. PMID 24162848 DOI: 10.1038/Nature12719  0.576
2013 Froberg JE, Yang L, Lee JT. Guided by RNAs: X-inactivation as a model for lncRNA function. Journal of Molecular Biology. 425: 3698-706. PMID 23816838 DOI: 10.1016/J.Jmb.2013.06.031  0.508
2013 Sun S, Del Rosario BC, Szanto A, Ogawa Y, Jeon Y, Lee JT. Jpx RNA activates Xist by evicting CTCF. Cell. 153: 1537-51. PMID 23791181 DOI: 10.1016/J.Cell.2013.05.028  0.559
2013 Lessing D, Anguera MC, Lee JT. X chromosome inactivation and epigenetic responses to cellular reprogramming. Annual Review of Genomics and Human Genetics. 14: 85-110. PMID 23662665 DOI: 10.1146/Annurev-Genom-091212-153530  0.508
2013 Sadreyev RI, Yildirim E, Pinter SF, Lee JT. Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. Proceedings of the National Academy of Sciences of the United States of America. 110: 6949-54. PMID 23564346 DOI: 10.1073/Pnas.1216449110  0.452
2013 Kung JT, Lee JT. RNA in the loop. Developmental Cell. 24: 565-7. PMID 23537627 DOI: 10.1016/J.Devcel.2013.03.009  0.455
2013 Lee JT, Bartolomei MS. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell. 152: 1308-23. PMID 23498939 DOI: 10.1016/J.Cell.2013.02.016  0.568
2013 Kung JT, Colognori D, Lee JT. Long noncoding RNAs: past, present, and future. Genetics. 193: 651-69. PMID 23463798 DOI: 10.1534/Genetics.112.146704  0.377
2013 Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell. 152: 727-42. PMID 23415223 DOI: 10.1016/J.Cell.2013.01.034  0.549
2012 Lee JT. Epigenetic regulation by long noncoding RNAs. Science (New York, N.Y.). 338: 1435-9. PMID 23239728 DOI: 10.1126/Science.1231776  0.404
2012 Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E. ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells (Dayton, Ohio). 30: 2672-82. PMID 22961808 DOI: 10.1002/Stem.1228  0.374
2012 Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, Lee JT. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome Research. 22: 1864-76. PMID 22948768 DOI: 10.1101/Gr.133751.111  0.559
2012 Erwin JA, del Rosario B, Payer B, Lee JT. An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation. Genetics. 192: 857-68. PMID 22942124 DOI: 10.1534/Genetics.112.144121  0.767
2012 Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 11: 75-90. PMID 22770242 DOI: 10.1016/J.Stem.2012.03.008  0.433
2012 Jeon Y, Sarma K, Lee JT. New and Xisting regulatory mechanisms of X chromosome inactivation. Current Opinion in Genetics & Development. 22: 62-71. PMID 22424802 DOI: 10.1016/J.Gde.2012.02.007  0.626
2012 Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nature Structural & Molecular Biology. 19: 56-61. PMID 22139016 DOI: 10.1038/Nsmb.2195  0.542
2012 Pinter SF, Pinter SF, Pinter SF, Jeon Y, Jeon Y, Jeon Y, Ohsumi TK, Ohsumi TK, Borowsky M, Borowsky M, Lee JT, Lee JT, Lee JT, Sadreyev RI, Sadreyev RI, et al. Abstract IA10: Spreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations Cancer Research. 72: IA10-IA10. DOI: 10.1158/1538-7445.Nonrna12-Ia10  0.609
2011 Lee JT. Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control. Nature Reviews. Molecular Cell Biology. 12: 815-26. PMID 22108600 DOI: 10.1038/Nrm3231  0.582
2011 Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ, Lee JT. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. Plos Genetics. 7: e1002248. PMID 21912526 DOI: 10.1371/Journal.Pgen.1002248  0.467
2011 Spencer RJ, del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics. 189: 441-54. PMID 21840866 DOI: 10.1534/Genetics.111.132662  0.518
2011 Jeon Y, Lee JT. YY1 tethers Xist RNA to the inactive X nucleation center. Cell. 146: 119-33. PMID 21729784 DOI: 10.1016/J.Cell.2011.06.026  0.553
2011 Payer B, Lee JT, Namekawa SH. X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Human Genetics. 130: 265-80. PMID 21667284 DOI: 10.1007/S00439-011-1024-7  0.597
2011 Kim DH, Jeon Y, Anguera MC, Lee JT. X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes. Seminars in Cell & Developmental Biology. 22: 336-42. PMID 21376830 DOI: 10.1016/J.Semcdb.2011.02.025  0.583
2011 Namekawa SH, Lee JT. Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos. Nature Protocols. 6: 270-84. PMID 21372809 DOI: 10.1038/Nprot.2010.195  0.425
2010 Sun S, Fukue Y, Nolen L, Sadreyev R, Lee JT. Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression. Transcription. 1: 46-56. PMID 21327163 DOI: 10.4161/trns.1.1.12401  0.471
2010 Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Molecular Cell. 40: 939-53. PMID 21172659 DOI: 10.1016/J.Molcel.2010.12.011  0.476
2010 Sarma K, Levasseur P, Aristarkhov A, Lee JT. Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome. Proceedings of the National Academy of Sciences of the United States of America. 107: 22196-201. PMID 21135235 DOI: 10.1073/Pnas.1009785107  0.496
2010 Tian D, Sun S, Lee JT. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell. 143: 390-403. PMID 21029862 DOI: 10.1016/J.Cell.2010.09.049  0.6
2010 Lee JT. The X as model for RNA's niche in epigenomic regulation. Cold Spring Harbor Perspectives in Biology. 2: a003749. PMID 20739414 DOI: 10.1101/Cshperspect.A003749  0.549
2010 Ahn JY, Lee JT. Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient. Bmc Developmental Biology. 10: 90. PMID 20727175 DOI: 10.1186/1471-213X-10-90  0.581
2010 Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 141: 872-83. PMID 20471072 DOI: 10.1016/J.Cell.2010.04.010  0.78
2010 Namekawa SH, Payer B, Huynh KD, Jaenisch R, Lee JT. Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Molecular and Cellular Biology. 30: 3187-205. PMID 20404085 DOI: 10.1128/Mcb.00227-10  0.68
2010 Paro R, Lee JT. Extending the frontiers of epigenetic regulation. Current Opinion in Genetics & Development. 20: 107-9. PMID 20382521 DOI: 10.1016/J.Gde.2010.03.011  0.307
2010 Erwin JA, Lee JT. Characterization of X-chromosome inactivation status in human pluripotent stem cells. Current Protocols in Stem Cell Biology. Unit 1B.6. PMID 20127856 DOI: 10.1002/9780470151808.Sc01B06S12  0.777
2009 Lee JT. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. Genes & Development. 23: 1831-42. PMID 19684108 DOI: 10.1101/Gad.1811209  0.537
2009 Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature. 460: 128-32. PMID 19536159 DOI: 10.1038/Nature08098  0.619
2009 Namekawa SH, Lee JT. XY and ZW: is meiotic sex chromosome inactivation the rule in evolution? Plos Genetics. 5: e1000493. PMID 19461890 DOI: 10.1371/Journal.Pgen.1000493  0.569
2009 Zhang LF, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, Lee JT. Telomeric RNAs mark sex chromosomes in stem cells. Genetics. 182: 685-98. PMID 19380904 DOI: 10.1534/Genetics.109.103093  0.546
2008 Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (New York, N.Y.). 322: 750-6. PMID 18974356 DOI: 10.1126/Science.1163045  0.806
2008 Payer B, Lee JT. X chromosome dosage compensation: how mammals keep the balance. Annual Review of Genetics. 42: 733-72. PMID 18729722 DOI: 10.1146/Annurev.Genet.42.110807.091711  0.551
2008 Lindroth AM, Park YJ, McLean CM, Dokshin GA, Persson JM, Herman H, Pasini D, Miró X, Donohoe ME, Lee JT, Helin K, Soloway PD. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. Plos Genetics. 4: e1000145. PMID 18670629 DOI: 10.1371/Journal.Pgen.1000145  0.597
2008 Ogawa Y, Sun BK, Lee JT. Intersection of the RNA interference and X-inactivation pathways. Science (New York, N.Y.). 320: 1336-41. PMID 18535243 DOI: 10.1126/Science.1157676  0.581
2008 Erwin JA, Lee JT. New twists in X-chromosome inactivation. Current Opinion in Cell Biology. 20: 349-55. PMID 18508252 DOI: 10.1016/J.Ceb.2008.04.007  0.8
2008 Tsai CL, Rowntree RK, Cohen DE, Lee JT. Higher order chromatin structure at the X-inactivation center via looping DNA. Developmental Biology. 319: 416-25. PMID 18501343 DOI: 10.1016/J.Ydbio.2008.04.010  0.547
2008 Silva SS, Rowntree RK, Mekhoubad S, Lee JT. X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 4820-5. PMID 18339803 DOI: 10.1073/Pnas.0712136105  0.498
2007 Lin H, Gupta V, Vermilyea MD, Falciani F, Lee JT, O'Neill LP, Turner BM. Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. Plos Biology. 5: e326. PMID 18076287 DOI: 10.1371/Journal.Pbio.0050326  0.592
2007 Xu N, Donohoe ME, Silva SS, Lee JT. Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nature Genetics. 39: 1390-6. PMID 17952071 DOI: 10.1038/Ng.2007.5  0.555
2007 Namekawa SH, VandeBerg JL, McCarrey JR, Lee JT. Sex chromosome silencing in the marsupial male germ line. Proceedings of the National Academy of Sciences of the United States of America. 104: 9730-5. PMID 17535928 DOI: 10.1073/Pnas.0700323104  0.554
2007 Zhang LF, Huynh KD, Lee JT. Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing. Cell. 129: 693-706. PMID 17512404 DOI: 10.1016/J.Cell.2007.03.036  0.548
2007 Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, ... ... Lee JT, et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 447: 167-77. PMID 17495919 DOI: 10.1038/Nature05805  0.383
2007 Kim S, Namekawa SH, Niswander LM, Ward JO, Lee JT, Bardwell VJ, Zarkower D. A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. Plos Genetics. 3: e62. PMID 17447844 DOI: 10.1371/Journal.Pgen.0030062  0.432
2007 Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, Lee JT. The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 15: 137-46. PMID 17333538 DOI: 10.1007/S10577-007-1121-6  0.578
2007 Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Molecular Cell. 25: 43-56. PMID 17218270 DOI: 10.1016/J.Molcel.2006.11.017  0.561
2007 Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, Lee JT. The DXPas34 repeat regulates random and imprinted X inactivation. Developmental Cell. 12: 57-71. PMID 17199041 DOI: 10.1016/J.Devcel.2006.11.014  0.788
2006 Anguera MC, Sun BK, Xu N, Lee JT. X-chromosome kiss and tell: How the Xs go their separate ways Cold Spring Harbor Symposia On Quantitative Biology. 71: 429-437. PMID 17381325 DOI: 10.1101/Sqb.2006.71.012  0.523
2006 Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W. Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development (Cambridge, England). 133: 4203-10. PMID 17021040 DOI: 10.1242/Dev.02612  0.475
2006 Rowntree RK, Lee JT. Mapping of DNA replication origins to noncoding genes of the X-inactivation center. Molecular and Cellular Biology. 26: 3707-17. PMID 16648467 DOI: 10.1128/Mcb.26.10.3707-3717.2006  0.518
2006 Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. Postmeiotic sex chromatin in the male germline of mice. Current Biology : Cb. 16: 660-7. PMID 16581510 DOI: 10.1016/J.Cub.2006.01.066  0.585
2006 Boumil RM, Ogawa Y, Sun BK, Huynh KD, Lee JT. Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Molecular and Cellular Biology. 26: 2109-17. PMID 16507990 DOI: 10.1128/Mcb.26.6.2109-2117.2006  0.474
2006 Sun BK, Deaton AM, Lee JT. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Molecular Cell. 21: 617-28. PMID 16507360 DOI: 10.1016/J.Molcel.2006.01.028  0.573
2006 Xu N, Tsai CL, Lee JT. Transient homologous chromosome pairing marks the onset of X inactivation. Science (New York, N.Y.). 311: 1149-52. PMID 16424298 DOI: 10.1126/Science.1122984  0.539
2006 Spencer RJ, Lee JT. 21 Large Noncoding RNAs in Mammalian Gene Dosage Regulation Cold Spring Harbor Monograph Archive. 43: 595-630. DOI: 10.1101/087969739.43.595  0.563
2005 Lee JT. Regulation of X-chromosome counting by Tsix and Xite sequences. Science (New York, N.Y.). 309: 768-71. PMID 16051795 DOI: 10.1126/Science.1113673  0.559
2005 Lee JT. Sex chromosome inactivation: the importance of pairing. Current Biology : Cb. 15: R249-52. PMID 15823524 DOI: 10.1016/J.Cub.2005.03.024  0.452
2005 Huynh KD, Lee JT. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nature Reviews. Genetics. 6: 410-8. PMID 15818384 DOI: 10.1038/Nrg1604  0.567
2005 Stavropoulos N, Rowntree RK, Lee JT. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Molecular and Cellular Biology. 25: 2757-69. PMID 15767680 DOI: 10.1128/Mcb.25.7.2757-2769.2005  0.587
2004 Huynh KD, Lee JT. A continuity of X-chromosome silence from gamete to zygote Cold Spring Harbor Symposia On Quantitative Biology. 69: 103-112. PMID 16117638 DOI: 10.1101/Sqb.2004.69.103  0.561
2004 Shibata S, Lee JT. Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice. Current Biology : Cb. 14: 1747-54. PMID 15458646 DOI: 10.1016/J.Cub.2004.09.053  0.515
2003 Lee JT. X-chromosome inactivation: a multi-disciplinary approach. Seminars in Cell & Developmental Biology. 14: 311-2. PMID 15015737 DOI: 10.1016/J.Semcdb.2003.09.025  0.51
2003 Huynh KD, Lee JT. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature. 426: 857-62. PMID 14661031 DOI: 10.1038/Nature02222  0.586
2003 Lee JT. Functional intergenic transcription: a case study of the X-inactivation centre. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 1417-23; discussion . PMID 14511490 DOI: 10.1098/Rstb.2003.1328  0.535
2003 O'Neill LP, Randall TE, Lavender J, Spotswood HT, Lee JT, Turner BM. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Human Molecular Genetics. 12: 1783-90. PMID 12874099 DOI: 10.1093/Hmg/Ddg193  0.541
2003 Ogawa Y, Lee JT. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Molecular Cell. 11: 731-43. PMID 12667455 DOI: 10.1016/S1097-2765(03)00063-7  0.587
2003 Lee JT. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting? Current Biology : Cb. 13: R242-54. PMID 12646153 DOI: 10.1016/S0960-9822(03)00162-3  0.59
2003 Shibata S, Lee JT. Characterization and quantitation of differential Tsix transcripts: implications for Tsix function. Human Molecular Genetics. 12: 125-36. PMID 12499393 DOI: 10.1093/Hmg/Ddg010  0.446
2003 Lee JT. Reply to "Is Tsix repression of Xist specific to mouse?" Nature Genetics. 33: 337-338. DOI: 10.1038/Ng0303-337B  0.393
2002 Ogawa Y, Lee JT. Antisense regulation in X inactivation and autosomal imprinting Cytogenetic and Genome Research. 99: 59-65. PMID 12900546 DOI: 10.1159/000071575  0.425
2002 Lee JT. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nature Genetics. 32: 195-200. PMID 12145659 DOI: 10.1038/Ng939  0.556
2002 Lee JT. Is X-chromosome inactivation a homology effect? Advances in Genetics. 46: 25-48. PMID 11931227  0.452
2002 Cohen DE, Lee JT. X-chromosome inactivation and the search for chromosome-wide silencers. Current Opinion in Genetics & Development. 12: 219-24. PMID 11893496 DOI: 10.1016/S0959-437X(02)00289-7  0.624
2002 Chao W, Huynh KD, Spencer RJ, Davidow LS, Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science (New York, N.Y.). 295: 345-7. PMID 11743158 DOI: 10.1126/Science.1065982  0.58
2001 Huynh KD, Lee JT. Imprinted X inactivation in eutherians: A model of gametic execution and zygotic relaxation Current Opinion in Cell Biology. 13: 690-697. PMID 11698184 DOI: 10.1016/S0955-0674(00)00272-6  0.608
2001 Boumil RM, Lee JT. Forty years of decoding the silence in X-chromosome inactivation Human Molecular Genetics. 10: 2225-2232. PMID 11673405 DOI: 10.1093/Hmg/10.20.2225  0.601
2001 Stavropoulos N, Lu N, Lee JT. A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice Proceedings of the National Academy of Sciences of the United States of America. 98: 10232-10237. PMID 11481444 DOI: 10.1073/Pnas.171243598  0.598
2000 Lee JT. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix Cell. 103: 17-27. PMID 11051544 DOI: 10.1016/S0092-8674(00)00101-X  0.566
2000 Reizis B, Lee JT, Leder P. Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 63: 149-52. PMID 10662556 DOI: 10.1006/Geno.1999.6068  0.397
2000 Warshawsky D, Stavropoulos N, Lee JT. Further examination of the Xist promoter-switch hypothesis in X inactivation: evidence against the existence and function of a P(0) promoter. Proceedings of the National Academy of Sciences of the United States of America. 96: 14424-9. PMID 10588721 DOI: 10.1073/Pnas.96.25.14424  0.453
1999 Lee JT, Lu N. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Cell. 99: 47-57. PMID 10520993 DOI: 10.1016/S0092-8674(00)80061-6  0.584
1999 Lee JT, Davidow LS, Warshawsky D. Tsix, a gene antisense to Xist at the X-inactivation centre. Nature Genetics. 21: 400-4. PMID 10192391 DOI: 10.1038/7734  0.592
1999 Lee JT, Lu N, Han Y. Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain. Proceedings of the National Academy of Sciences of the United States of America. 96: 3836-41. PMID 10097124 DOI: 10.1073/Pnas.96.7.3836  0.621
1998 Jaenisch R, Beard C, Lee J, Marahrens Y, Panning B. Mammalian X chromosome inactivation. Novartis Foundation Symposium. 214: 200-9; discussion 20. PMID 9601019 DOI: 10.1002/9780470515501.Ch12  0.792
1997 Lee JT, Jaenisch R. The (epi)genetic control of mammalian X-chromosome inactivation. Current Opinion in Genetics & Development. 7: 274-80. PMID 9115428 DOI: 10.1016/S0959-437X(97)80138-4  0.651
1997 Lee JT, Jaenisch R. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome. Nature. 386: 275-9. PMID 9069285 DOI: 10.1038/386275A0  0.702
1996 Lee JT, Jaenisch R. A method for high efficiency YAC lipofection into murine embryonic stem cells. Nucleic Acids Research. 24: 5054-5. PMID 9016681 DOI: 10.1093/Nar/24.24.5054  0.524
1996 Lee JT, Strauss WM, Dausman JA, Jaenisch R. A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell. 86: 83-94. PMID 8689690 DOI: 10.1016/S0092-8674(00)80079-3  0.685
1992 Lee JT, Murgia A, Sosnoski DM, Olivos IM, Nussbaum RL. Construction and characterization of a yeast artificial chromosome library for Xpter-Xq27.3: a systematic determination of cocloning rate and X-chromosome representation. Genomics. 12: 526-33. PMID 1559703  0.606
1989 Lee JT, Nussbaum RL. An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells. The Journal of Clinical Investigation. 84: 1762-6. PMID 2556444 DOI: 10.1172/JCI114360  0.413
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