| Year |
Citation |
Score |
| 2023 |
Guarente L, Sinclair DA, Kroemer G. Human trials exploring anti-aging medicines. Cell Metabolism. PMID 38181790 DOI: 10.1016/j.cmet.2023.12.007 |
0.369 |
|
| 2019 |
Igarashi M, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T, Guarente L. NAD supplementation rejuvenates aged gut adult stem cells. Aging Cell. e12935. PMID 30917412 DOI: 10.1111/Acel.12935 |
0.32 |
|
| 2019 |
Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, ... ... Guarente L, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 176: 944-945. PMID 30735637 DOI: 10.1016/j.cell.2019.01.026 |
0.34 |
|
| 2018 |
Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, ... ... Guarente L, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 173: 74-89.e20. PMID 29570999 DOI: 10.1016/j.cell.2018.02.008 |
0.461 |
|
| 2017 |
Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L. Mutations that Allow SIR2 Orthologs to Function in a NAD(+)-Depleted Environment. Cell Reports. 18: 2310-2319. PMID 28273448 DOI: 10.1016/J.Celrep.2017.02.031 |
0.618 |
|
| 2016 |
Guarente L. Overcoming ATM Deficiency by Activating the NAD/SIRT1 Axis. Cell Metabolism. 24: 526-528. PMID 27732834 DOI: 10.1016/J.Cmet.2016.09.019 |
0.336 |
|
| 2016 |
Igarashi M, Guarente L. mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction. Cell. 166: 436-450. PMID 27345368 DOI: 10.1016/J.Cell.2016.05.044 |
0.307 |
|
| 2016 |
Cunha-Santos J, Duarte-Neves J, Carmona V, Guarente L, Pereira de Almeida L, Cavadas C. Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. Nature Communications. 7: 11445. PMID 27165717 DOI: 10.1038/Ncomms11445 |
0.303 |
|
| 2015 |
Chalkiadaki A, Guarente L. The multifaceted functions of sirtuins in cancer. Nature Reviews. Cancer. 15: 608-24. PMID 26383140 DOI: 10.1038/Nrc3985 |
0.325 |
|
| 2014 |
Guarente L. Linking DNA damage, NAD(+)/SIRT1, and aging. Cell Metabolism. 20: 706-7. PMID 25440052 DOI: 10.1016/J.Cmet.2014.10.015 |
0.318 |
|
| 2014 |
Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, White FM, Sassone-Corsi P, Guarente L. SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development (Cambridge, England). 141: 3495-504. PMID 25142464 DOI: 10.1242/Dev.110627 |
0.327 |
|
| 2014 |
Nakagawa T, Guarente L. SnapShot: sirtuins, NAD, and aging. Cell Metabolism. 20: 192-192.e1. PMID 24988458 DOI: 10.1016/J.Cmet.2014.06.001 |
0.359 |
|
| 2014 |
Guarente L. The many faces of sirtuins: Sirtuins and the Warburg effect. Nature Medicine. 20: 24-5. PMID 24398961 DOI: 10.1038/Nm.3438 |
0.345 |
|
| 2014 |
Chang HC, Guarente L. SIRT1 and other sirtuins in metabolism. Trends in Endocrinology and Metabolism: Tem. 25: 138-45. PMID 24388149 DOI: 10.1016/J.Tem.2013.12.001 |
0.339 |
|
| 2014 |
Sinclair DA, Guarente L. Small-molecule allosteric activators of sirtuins. Annual Review of Pharmacology and Toxicology. 54: 363-80. PMID 24160699 DOI: 10.1146/Annurev-Pharmtox-010611-134657 |
0.502 |
|
| 2013 |
Guarente L. Introduction: sirtuins in aging and diseases. Methods in Molecular Biology (Clifton, N.J.). 1077: 3-10. PMID 24014396 DOI: 10.1007/978-1-62703-637-5_1 |
0.399 |
|
| 2013 |
Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 154: 430-41. PMID 23870130 DOI: 10.1016/J.Cell.2013.06.016 |
0.355 |
|
| 2013 |
Herskovits AZ, Guarente L. Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Research. 23: 746-58. PMID 23689277 DOI: 10.1038/Cr.2013.70 |
0.304 |
|
| 2013 |
Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. Embo Molecular Medicine. 5: 430-40. PMID 23364955 DOI: 10.1002/Emmm.201201606 |
0.314 |
|
| 2013 |
Libert S, Guarente L. Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annual Review of Physiology. 75: 669-84. PMID 23043250 DOI: 10.1146/Annurev-Physiol-030212-183800 |
0.322 |
|
| 2012 |
Chalkiadaki A, Guarente L. Sirtuins mediate mammalian metabolic responses to nutrient availability. Nature Reviews. Endocrinology. 8: 287-96. PMID 22249520 DOI: 10.1038/Nrendo.2011.225 |
0.323 |
|
| 2012 |
Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, Guarente L. SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 124-32. PMID 22219275 DOI: 10.1523/Jneurosci.3442-11.2012 |
0.309 |
|
| 2012 |
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/Nature10602 |
0.315 |
|
| 2012 |
Guarente L. Sirtuins, aging and diseases Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O8 |
0.368 |
|
| 2011 |
Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, ... Guarente L, et al. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell. 147: 1459-72. PMID 22169038 DOI: 10.1016/J.Cell.2011.10.054 |
0.324 |
|
| 2011 |
Guarente L. Sirtuins, aging, and metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 81-90. PMID 22114328 DOI: 10.1101/Sqb.2011.76.010629 |
0.342 |
|
| 2011 |
Chalkiadaki A, Guarente L. Metabolic signals regulate SIRT1 expression. Embo Reports. 12: 985-6. PMID 21941300 DOI: 10.1038/Embor.2011.179 |
0.311 |
|
| 2011 |
Viswanathan M, Guarente L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature. 477: E1-2. PMID 21938026 DOI: 10.1038/Nature10440 |
0.315 |
|
| 2011 |
Guarente L. Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging Developmental Cell. 20: e1. DOI: 10.1016/J.Devcel.2011.04.004 |
0.361 |
|
| 2010 |
Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/Science.329.5995.1012 |
0.432 |
|
| 2010 |
Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, ... ... Guarente L, et al. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. Plos One. 5: e11755. PMID 20668706 DOI: 10.1371/Journal.Pone.0011755 |
0.312 |
|
| 2010 |
Donmez G, Guarente L. Aging and disease: connections to sirtuins. Aging Cell. 9: 285-90. PMID 20409078 DOI: 10.1111/J.1474-9726.2010.00548.X |
0.347 |
|
| 2009 |
Blander G, Bhimavarapu A, Mammone T, Maes D, Elliston K, Reich C, Matsui MS, Guarente L, Loureiro JJ. SIRT1 promotes differentiation of normal human keratinocytes. The Journal of Investigative Dermatology. 129: 41-9. PMID 18563176 DOI: 10.1038/Jid.2008.179 |
0.333 |
|
| 2008 |
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 456: 269-73. PMID 18849969 DOI: 10.1038/Nature07349 |
0.351 |
|
| 2008 |
Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes & Development. 22: 1753-7. PMID 18550784 DOI: 10.1101/Gad.1650608 |
0.316 |
|
| 2008 |
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/Journal.Pone.0002020 |
0.402 |
|
| 2008 |
Guarente L. Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell. 132: 171-6. PMID 18243090 DOI: 10.1016/J.Cell.2008.01.007 |
0.308 |
|
| 2007 |
Guarente L. Sirtuins in aging and disease. Cold Spring Harbor Symposia On Quantitative Biology. 72: 483-8. PMID 18419308 DOI: 10.1101/Sqb.2007.72.024 |
0.362 |
|
| 2007 |
Westphal CH, Dipp MA, Guarente L. A therapeutic role for sirtuins in diseases of aging? Trends in Biochemical Sciences. 32: 555-60. PMID 17980602 DOI: 10.1016/J.Tibs.2007.09.008 |
0.377 |
|
| 2007 |
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Molecular Cell. 28: 91-106. PMID 17936707 DOI: 10.1016/J.Molcel.2007.07.032 |
0.35 |
|
| 2007 |
Chen D, Guarente L. SIR2: a potential target for calorie restriction mimetics. Trends in Molecular Medicine. 13: 64-71. PMID 17207661 DOI: 10.1016/J.Molmed.2006.12.004 |
0.358 |
|
| 2007 |
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of Biological Chemistry. 282: 151-8. PMID 17098745 DOI: 10.1074/Jbc.M605904200 |
0.303 |
|
| 2006 |
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057 |
0.594 |
|
| 2006 |
Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell. 125: 1165-77. PMID 16777605 DOI: 10.1016/J.Cell.2006.04.036 |
0.367 |
|
| 2006 |
Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes & Development. 20: 1075-80. PMID 16618798 DOI: 10.1101/Gad.1399706 |
0.371 |
|
| 2006 |
Sinclair DA, Lin SJ, Guarente L. Life-span extension in yeast. Science (New York, N.Y.). 312: 195-7; author reply . PMID 16614198 DOI: 10.1126/Science.312.5771.195D |
0.492 |
|
| 2006 |
Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Scientific American. 294: 48-51, 54-7. PMID 16502611 DOI: 10.1038/SCIENTIFICAMERICAN0306-48 |
0.411 |
|
| 2006 |
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Guarente L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/J.Cell.2005.11.044 |
0.369 |
|
| 2005 |
Chen D, Steele AD, Lindquist S, Guarente L. Increase in activity during calorie restriction requires Sirt1. Science (New York, N.Y.). 310: 1641. PMID 16339438 DOI: 10.1126/Science.1118357 |
0.33 |
|
| 2005 |
Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, et al. Science fact and the SENS agenda. What can we reasonably expect from ageing research? Embo Reports. 6: 1006-8. PMID 16264422 DOI: 10.1038/Sj.Embor.7400555 |
0.31 |
|
| 2005 |
Viswanathan M, Kim SK, Berdichevsky A, Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Developmental Cell. 9: 605-15. PMID 16256736 DOI: 10.1016/J.Devcel.2005.09.017 |
0.338 |
|
| 2005 |
Guarente L. Calorie restriction and SIR2 genes--towards a mechanism. Mechanisms of Ageing and Development. 126: 923-8. PMID 15941577 DOI: 10.1016/J.Mad.2005.03.013 |
0.35 |
|
| 2005 |
Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. The Journal of Biological Chemistry. 280: 21313-20. PMID 15795229 DOI: 10.1074/Jbc.M413296200 |
0.324 |
|
| 2005 |
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nature Reviews. Molecular Cell Biology. 6: 298-305. PMID 15768047 DOI: 10.1038/Nrm1616 |
0.308 |
|
| 2005 |
Guarente L, Picard F. Calorie restriction--the SIR2 connection. Cell. 120: 473-82. PMID 15734680 DOI: 10.1016/J.Cell.2005.01.029 |
0.324 |
|
| 2005 |
Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro Journal of Biological Chemistry. 280: 9780-9785. PMID 15640142 DOI: 10.1074/Jbc.M414080200 |
0.342 |
|
| 2004 |
Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Molecular and Cellular Biology. 24: 8437-46. PMID 15367665 DOI: 10.1128/Mcb.24.19.8437-8446.2004 |
0.337 |
|
| 2004 |
Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/Bj20041081 |
0.329 |
|
| 2004 |
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics. 36: 877-82. PMID 15235603 DOI: 10.1038/Ng1389 |
0.325 |
|
| 2004 |
Blander G, Guarente L. The Sir2 family of protein deacetylases Annual Review of Biochemistry. 73: 417-435. PMID 15189148 DOI: 10.1146/Annurev.Biochem.73.011303.073651 |
0.404 |
|
| 2004 |
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429: 771-6. PMID 15175761 DOI: 10.1038/Nature02583 |
0.357 |
|
| 2004 |
Kaeberlein M, Andalis AA, Liszt GB, Fink GR, Guarente L. Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics. 166: 1661-72. PMID 15126388 DOI: 10.1534/Genetics.166.4.1661 |
0.548 |
|
| 2004 |
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. Mammalian SIRT1 Represses Forkhead Transcription Factors Cell. 116: 551-563. PMID 14980222 DOI: 10.1016/S0092-8674(04)00126-6 |
0.349 |
|
| 2004 |
Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes & Development. 18: 12-6. PMID 14724176 DOI: 10.1101/Gad.1164804 |
0.314 |
|
| 2003 |
Blander G, De Oliveira RM, Conboy CM, Haigis M, Guarente L. Superoxide dismutase 1 knock-down induces senescence in human fibroblasts Journal of Biological Chemistry. 278: 38966-38969. PMID 12871978 DOI: 10.1074/Jbc.M307146200 |
0.321 |
|
| 2003 |
Lin SJ, Guarente L. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Current Opinion in Cell Biology. 15: 241-6. PMID 12648681 DOI: 10.1016/S0955-0674(03)00006-1 |
0.342 |
|
| 2003 |
Hekimi S, Guarente L. Genetics and the specificity of the aging process Science. 299: 1351-1354. PMID 12610295 DOI: 10.1126/Science.1082358 |
0.377 |
|
| 2002 |
Kaeberlein M, Andalis AA, Fink GR, Guarente L. High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Molecular and Cellular Biology. 22: 8056-66. PMID 12391171 DOI: 10.1128/Mcb.22.22.8056-8066.2002 |
0.561 |
|
| 2002 |
Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 418: 344-8. PMID 12124627 DOI: 10.1038/Nature00829 |
0.545 |
|
| 2002 |
Armstrong CM, Kaeberlein M, Imai SI, Guarente L. Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Molecular Biology of the Cell. 13: 1427-38. PMID 11950950 DOI: 10.1091/Mbc.01-10-0482 |
0.562 |
|
| 2002 |
Kaeberlein M, Guarente L. Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity Genetics. 160: 83-95. PMID 11805047 |
0.503 |
|
| 2002 |
Tissenbaum HA, Guarente L. Model organisms as a guide to mammalian aging Developmental Cell. 2: 9-19. PMID 11782310 DOI: 10.1016/S1534-5807(01)00098-3 |
0.377 |
|
| 2001 |
Guarente L. SIR2 Proteins Regulate Aging in Response to Nutrients. Thescientificworldjournal. 1: 75. PMID 30147549 DOI: 10.1100/Tsw.2001.139 |
0.415 |
|
| 2001 |
Kaeberlein M, McVey M, Guarente L. Using yeast to discover the fountain of youth. Science of Aging Knowledge Environment : Sage Ke. 2001: pe1. PMID 14602950 DOI: 10.1126/Sageke.2001.1.Pe1 |
0.561 |
|
| 2001 |
Vaziri H, Dessain SK, Eaton EN, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase Cell. 107: 149-159. PMID 11672523 DOI: 10.1016/S0092-8674(01)00527-X |
0.366 |
|
| 2001 |
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107: 137-48. PMID 11672522 DOI: 10.1016/S0092-8674(01)00524-4 |
0.315 |
|
| 2001 |
Guarente L. SIR2 and aging - The exception that proves the rule Trends in Genetics. 17: 391-392. PMID 11418219 DOI: 10.1016/S0168-9525(01)02339-3 |
0.312 |
|
| 2001 |
Hu P, Beresten SF, van Brabant AJ, Ye TZ, Pandolfi PP, Johnson FB, Guarente L, Ellis NA. Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. Human Molecular Genetics. 10: 1287-98. PMID 11406610 DOI: 10.1093/Hmg/10.12.1287 |
0.342 |
|
| 2001 |
Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature. 410: 227-230. PMID 11242085 DOI: 10.1038/35065638 |
0.425 |
|
| 2001 |
Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L. The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. The Embo Journal. 20: 905-13. PMID 11179234 DOI: 10.1093/Emboj/20.4.905 |
0.358 |
|
| 2000 |
Imai S, Johnson FB, Marciniak RA, McVey M, Park PU, Guarente L. Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. Cold Spring Harbor Symposia On Quantitative Biology. 65: 297-302. PMID 12760043 DOI: 10.1101/Sqb.2000.65.297 |
0.301 |
|
| 2000 |
Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 408: 255-62. PMID 11089983 DOI: 10.1038/35041700 |
0.387 |
|
| 2000 |
Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in saccharomyces cerevisiae Science. 289: 2126-2128. PMID 11000115 DOI: 10.1126/Science.289.5487.2126 |
0.389 |
|
| 2000 |
Lombard DB, Guarente L. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres Cancer Research. 60: 2331-2334. PMID 10811102 DOI: 10.1007/978-1-4615-1405-3_4 |
0.309 |
|
| 2000 |
Guarente L. Sir2 links chromatin silencing, metabolism, and aging Genes and Development. 14: 1021-1026. PMID 10809662 DOI: 10.1101/Gad.14.9.1021 |
0.32 |
|
| 2000 |
Marciniak RA, Johnson FB, Guarente L. Dyskeratosis congenita, telomeres and human ageing. Trends in Genetics : Tig. 16: 193-5. PMID 10782108 DOI: 10.1016/S0168-9525(00)01984-3 |
0.313 |
|
| 2000 |
Yankiwski V, Marciniak RA, Guarente L, Neff NF. Nuclear structure in normal and Bloom syndrome cells Proceedings of the National Academy of Sciences of the United States of America. 97: 5214-5219. PMID 10779560 DOI: 10.1073/Pnas.090525897 |
0.333 |
|
| 2000 |
Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, Bronson R, Buhlmann JE, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L. Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Molecular and Cellular Biology. 20: 3286-91. PMID 10757812 DOI: 10.1128/Mcb.20.9.3286-3291.2000 |
0.346 |
|
| 2000 |
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403: 795-800. PMID 10693811 DOI: 10.1038/35001622 |
0.54 |
|
| 2000 |
Guarente L, Silver PA. Nucleus and gene expression: Function following form in the nucleus Current Opinion in Cell Biology. 12: 279. DOI: 10.1016/S0955-0674(00)00088-0 |
0.491 |
|
| 1999 |
Guarente L. Mutant mice live longer Nature. 402: 243+245. PMID 10580490 DOI: 10.1038/46185 |
0.315 |
|
| 1999 |
Guarente L. Diverse and dynamic functions of the Sir silencing complex Nature Genetics. 23: 281-285. PMID 10545947 DOI: 10.1038/15458 |
0.374 |
|
| 1999 |
Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes & Development. 13: 2570-80. PMID 10521401 DOI: 10.1101/Gad.13.19.2570 |
0.584 |
|
| 1999 |
Ashrafi K, Sinclair D, Gordon JI, Guarente L. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 96: 9100-5. PMID 10430902 DOI: 10.1073/Pnas.96.16.9100 |
0.514 |
|
| 1999 |
Mills KD, Sinclair DA, Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. 97: 609-20. PMID 10367890 DOI: 10.1016/S0092-8674(00)80772-2 |
0.309 |
|
| 1999 |
Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, Silver PA, Keil RL, Guarente L. Elimination of replication block protein Fob1 extends the life span of yeast mother cells Molecular Cell. 3: 447-455. PMID 10230397 DOI: 10.1016/S1097-2765(00)80472-4 |
0.675 |
|
| 1999 |
Park PU, Defossez PA, Guarente L. Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae Molecular and Cellular Biology. 19: 3848-3856. PMID 10207108 DOI: 10.1128/Mcb.19.5.3848 |
0.381 |
|
| 1999 |
Johnson FB, Sinclair DA, Guarente L. Molecular biology of aging. Cell. 96: 291-302. PMID 9988222 DOI: 10.1016/S0092-8674(00)80567-X |
0.303 |
|
| 1999 |
King DA, Zhang L, Guarente L, Marmorstein R. Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein. Nature Structural Biology. 6: 64-71. PMID 9886294 DOI: 10.1038/4940 |
0.323 |
|
| 1999 |
King DA, Zhang L, Guarente L, Marmorstein R. Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation. Nature Structural Biology. 6: 22-7. PMID 9886287 DOI: 10.1038/4893 |
0.356 |
|
| 1998 |
Defossez PA, Park PU, Guarente L. Vicious circles: A mechanism for yeast aging Current Opinion in Microbiology. 1: 707-711. PMID 10066542 DOI: 10.1016/S1369-5274(98)80119-7 |
0.354 |
|
| 1998 |
Sinclair D, Mills K, Guarente L. Aging in Saccharomyces cerevisiae Annual Review of Microbiology. 52: 533-560. PMID 9891807 DOI: 10.1146/Annurev.Micro.52.1.533 |
0.53 |
|
| 1998 |
Johnson FB, Marciniak RA, Guarente L. Telomeres, the nucleolus and aging. Current Opinion in Cell Biology. 10: 332-8. PMID 9640533 DOI: 10.1016/S0955-0674(98)80008-2 |
0.352 |
|
| 1998 |
Marciniak RA, Lombard DB, Johnson FB, Guarente L. Nucleolar localization of the Werner syndrome protein in human cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 6887-92. PMID 9618508 DOI: 10.1073/Pnas.95.12.6887 |
0.313 |
|
| 1998 |
Sinclair DA, Mills K, Guarente L. Molecular mechanisms of yeast aging Trends in Biochemical Sciences. 23: 131-134. PMID 9584615 DOI: 10.1016/S0968-0004(98)01188-8 |
0.342 |
|
| 1997 |
Sinclair DA, Guarente L. Extrachromosomal rDNA circles - A cause of aging in yeast Cell. 91: 1033-1042. PMID 9428525 DOI: 10.1016/S0092-8674(00)80493-6 |
0.356 |
|
| 1997 |
Mcnabb DS, Tseng KAS, Guarente L. The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor Molecular and Cellular Biology. 17: 7008-7018. PMID 9372932 DOI: 10.1128/Mcb.17.12.7008 |
0.384 |
|
| 1997 |
Guarente L. Link between aging and the nucleolus Genes and Development. 11: 2449-2455. PMID 9334311 DOI: 10.1101/Gad.11.19.2449 |
0.311 |
|
| 1997 |
Sinclair DA, Mills K, Guarente L. Accelerated aging and nucleolar fragmentation in yeast SGS1 mutants Science. 277: 1313-1316. PMID 9271578 DOI: 10.1126/Science.277.5330.1313 |
0.413 |
|
| 1997 |
McNabb DS, Pak SM, Guarente L. Cassette for the generation of sequential gene disruptions in the yeast Schizosaccharomyces pombe Biotechniques. 22: 1134-1139. PMID 9187764 DOI: 10.2144/97226Rr01 |
0.34 |
|
| 1997 |
Horiuchi J, Silverman N, Piña B, Marcus GA, Guarente L. ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3 Molecular and Cellular Biology. 17: 3220-3228. PMID 9154821 DOI: 10.1128/Mcb.17.6.3220 |
0.358 |
|
| 1997 |
Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell. 89: 381-91. PMID 9150138 DOI: 10.1016/S0092-8674(00)80219-6 |
0.397 |
|
| 1997 |
Smeal T, Guarente L. Mechanisms of cellular senescence Current Opinion in Genetics and Development. 7: 281-287. PMID 9115418 DOI: 10.1016/S0959-437X(97)80139-6 |
0.399 |
|
| 1997 |
Guarente L. What makes us tick? Science. 275: 943-944. PMID 9053999 DOI: 10.1126/Science.275.5302.943 |
0.394 |
|
| 1996 |
Kennedy BK, Guarente L. Genetic analysis of aging in Saccharomyces cerevisiae Trends in Genetics. 12: 355-359. PMID 8855665 DOI: 10.1016/S0168-9525(96)80018-7 |
0.337 |
|
| 1996 |
Guarente L. Do changes in chromosomes cause aging? Cell. 86: 9-12. PMID 8689691 DOI: 10.1016/S0092-8674(00)80072-0 |
0.327 |
|
| 1996 |
Marcus GA, Horiuchi J, Silverman N, Guarente L. ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription Molecular and Cellular Biology. 16: 3197-3205. PMID 8649430 DOI: 10.1128/Mcb.16.6.3197 |
0.403 |
|
| 1996 |
Knaus R, Pollock R, Guarente L. Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4 Embo Journal. 15: 1933-1940. PMID 8617240 DOI: 10.1002/J.1460-2075.1996.Tb00544.X |
0.366 |
|
| 1996 |
Smeal T, Claus J, Kennedy B, Cole F, Guarente L. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae Cell. 84: 633-642. PMID 8598049 DOI: 10.1016/S0092-8674(00)81038-7 |
0.398 |
|
| 1995 |
Guarente L. Transcriptional coactivators in yeast and beyond Trends in Biochemical Sciences. 20: 517-521. PMID 8571454 DOI: 10.1016/S0968-0004(00)89120-3 |
0.365 |
|
| 1995 |
Horiuchi J, Silverman N, Marcus GA, Guarente L. ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex Molecular and Cellular Biology. 15: 1203-1209. PMID 7862114 DOI: 10.1128/Mcb.15.3.1203 |
0.342 |
|
| 1995 |
Kennedy BK, Austriaco NR, Zhang J, Guarente L. Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae Cell. 80: 485-496. PMID 7859289 DOI: 10.1016/0092-8674(95)90499-9 |
0.374 |
|
| 1995 |
Zhang L, Guarente L. Heme binds to a short sequence that serves a regulatory function in diverse proteins Embo Journal. 14: 313-320. PMID 7835342 DOI: 10.1002/J.1460-2075.1995.Tb07005.X |
0.353 |
|
| 1995 |
McNabb DS, Xing Y, Guarente L. Cloning of yeast HAP5: A novel subunit of a heterotrimeric complex required for CCAAT binding Genes and Development. 9: 47-58. PMID 7828851 DOI: 10.1101/Gad.9.1.47 |
0.363 |
|
| 1995 |
Haldi ML, Guarente L. Multiple domains mediate heme control of the yeast activator HAP1 Mgg Molecular & General Genetics. 248: 229-235. PMID 7651346 DOI: 10.1007/Bf02190805 |
0.341 |
|
| 1995 |
Wang L, Turcotte B, Guarente L, Berger SL. The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements Gene. 158: 163-170. PMID 7607537 DOI: 10.1016/0378-1119(95)00126-Q |
0.564 |
|
| 1995 |
Guarente L, Bermingham-McDonogh O. Conservation and evolution of transcriptional mechanisms in eukaryotes. Trends in Genetics : Tig. 8: 27-32. PMID 1369732 DOI: 10.1016/0168-9525(92)90021-U |
0.363 |
|
| 1994 |
Xing Y, Zhang S, Olesen JT, Rich A, Guarente L. Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short α-helix in HAP2 Proceedings of the National Academy of Sciences of the United States of America. 91: 3009-3013. PMID 8159696 DOI: 10.1073/Pnas.91.8.3009 |
0.316 |
|
| 1994 |
Silverman N, Agapite J, Guarente L. Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription Proceedings of the National Academy of Sciences of the United States of America. 91: 11665-11668. PMID 7972120 DOI: 10.1073/Pnas.91.24.11665 |
0.385 |
|
| 1994 |
Zhang L, Guarente L. The yeast activator HAP1 - A GAL4 family member-binds DNA in a directly repeated orientation Genes and Development. 8: 2110-2119. PMID 7958882 DOI: 10.1101/Gad.8.17.2110 |
0.326 |
|
| 1994 |
Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L. Functional similarity and physical association between GCN5 and ADA2: Putative transcriptional adaptors Embo Journal. 13: 4807-4815. PMID 7957049 DOI: 10.1002/J.1460-2075.1994.Tb06806.X |
0.586 |
|
| 1993 |
Zhang L, Bermingham-McDonogh O, Turcotte B, Guarente L. Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1. Proceedings of the National Academy of Sciences of the United States of America. 90: 2851-5. PMID 8464899 DOI: 10.1073/Pnas.90.7.2851 |
0.325 |
|
| 1993 |
Piña B, Berger S, Marcus GA, Silverman N, Agapite J, Guarente L. ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2. Molecular and Cellular Biology. 13: 5981-9. PMID 8413201 DOI: 10.1128/Mcb.13.10.5981 |
0.591 |
|
| 1993 |
Xing Y, Fikes J, Guarente L. Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. The Embo Journal. 12: 4647-4655. DOI: 10.1002/J.1460-2075.1993.Tb06153.X |
0.319 |
|
| 1992 |
Berger SL, Piña B, Silverman N, Marcus GA, Agapite J, Regier JL, Triezenberg SJ, Guarente L. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains Cell. 70: 251-265. PMID 1638630 DOI: 10.1016/0092-8674(92)90100-Q |
0.568 |
|
| 1992 |
Eide D, Guarente L. Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae Microbiology. 138: 347-354. PMID 1564445 DOI: 10.1099/00221287-138-2-347 |
0.325 |
|
| 1992 |
Turcotte B, Guarente L. HAP1 positive control mutants specific for one of two binding sites. Genes & Development. 6: 2001-9. PMID 1327959 DOI: 10.1101/Gad.6.10.2001 |
0.364 |
|
| 1992 |
Guarente L. 38 Mechanism and Regulation of Transcriptional Activation in Eukaryotes: Conserved Features from Yeasts to Humans Cold Spring Harbor Monograph Archive. 1007-1036. DOI: 10.1101/087969425.22B.1007 |
0.422 |
|
| 1992 |
Guarente L. 2 Messenger RNA Transcription and Its Control in Saccharomyces cerevisiae Cold Spring Harbor Monograph Archive. 49-98. DOI: 10.1101/087969365.21B.49 |
0.38 |
|
| 1991 |
Olesen JT, Guarente L. The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. Genes & Development. 4: 1714-29. PMID 2123465 DOI: 10.1101/Gad.4.10.1714 |
0.378 |
|
| 1991 |
Schneider JC, Guarente L. Vectors for expression of cloned genes in yeast: Regulation, overproduction, and underproduction Methods in Enzymology. 194: 373-388. PMID 2005797 DOI: 10.1016/0076-6879(91)94028-B |
0.371 |
|
| 1991 |
Becker DM, Fikes JD, Guarente L. A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. Proceedings of the National Academy of Sciences of the United States of America. 88: 1968-72. PMID 2000400 DOI: 10.1073/Pnas.88.5.1968 |
0.393 |
|
| 1991 |
Olesen JT, Fikes JD, Guarente L. The Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae HAP2 reveals selective and stringent conservation of the small essential core protein domain. Molecular and Cellular Biology. 11: 611-9. PMID 1899284 DOI: 10.1128/Mcb.11.2.611 |
0.381 |
|
| 1991 |
Schneider JC, Guarente L. Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4 Molecular and Cellular Biology. 11: 4934-4942. PMID 1656218 DOI: 10.1128/Mcb.11.10.4934 |
0.322 |
|
| 1990 |
Fikes JD, Becker DM, Winston F, Guarente L. Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Nature. 346: 291-4. PMID 2197558 DOI: 10.1038/346291A0 |
0.41 |
|
| 1990 |
Berger SL, Cress WD, Cress A, Triezenberg SJ, Guarente L. Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell. 61: 1199-208. PMID 2163758 DOI: 10.1016/0092-8674(90)90684-7 |
0.561 |
|
| 1990 |
Kim KS, Pfeifer K, Powell L, Guarente L. Internal deletions in the yeast transcriptional activator HAP1 have opposite effects at two sequence elements. Proceedings of the National Academy of Sciences of the United States of America. 87: 4524-8. PMID 2162046 DOI: 10.1073/Pnas.87.12.4524 |
0.367 |
|
| 1989 |
Buratowski S, Hahn S, Guarente L, Sharp PA. Five intermediate complexes in transcription initiation by RNA polymerase II. Cell. 56: 549-61. PMID 2917366 DOI: 10.1016/0092-8674(89)90578-3 |
0.314 |
|
| 1989 |
Forsburg SL, Guarente L. Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes & Development. 3: 1166-78. PMID 2676721 DOI: 10.1101/Gad.3.8.1166 |
0.405 |
|
| 1989 |
Osborne BI, Guarente L. Mutational analysis of a yeast transcriptional terminator. Proceedings of the National Academy of Sciences of the United States of America. 86: 4097-101. PMID 2657739 DOI: 10.1073/Pnas.86.11.4097 |
0.374 |
|
| 1989 |
Elledge SJ, Sugiono P, Guarente L, Davis RW. Genetic selection for genes encoding sequence-specific DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 3689-93. PMID 2657725 DOI: 10.1073/Pnas.86.10.3689 |
0.515 |
|
| 1989 |
Pfeifer K, Kim KS, Kogan S, Guarente L. Functional dissection and sequence of yeast HAP1 activator. Cell. 56: 291-301. PMID 2643482 DOI: 10.1016/0092-8674(89)90903-3 |
0.334 |
|
| 1989 |
Hahn S, Buratowski S, Sharp PA, Guarente L. Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 86: 5718-22. PMID 2569738 DOI: 10.1073/Pnas.86.15.5718 |
0.312 |
|
| 1989 |
Forsburg SL, Guarente L. Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. Annual Review of Cell Biology. 5: 153-80. PMID 2557058 DOI: 10.1146/Annurev.Cb.05.110189.001101 |
0.315 |
|
| 1989 |
Hahn S, Buratowski S, Sharp PA, Guarente L. Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions. Cell. 58: 1173-81. PMID 2550146 DOI: 10.1016/0092-8674(89)90515-1 |
0.414 |
|
| 1989 |
Kim KS, Guarente L. Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI. Nature. 342: 200-3. PMID 2509943 DOI: 10.1038/342200A0 |
0.405 |
|
| 1989 |
Hahn S, Buratowski S, Sharp P, Guarente L. Isolation of the gene encoding the yeast TATA binding TFIID: a gene identical to the SPT15 suppressor of Ty element insertions Trends in Genetics. 5: 393. DOI: 10.1016/0168-9525(89)90187-X |
0.342 |
|
| 1988 |
Guarente L. Regulatory proteins in yeast. Annual Review of Genetics. 21: 425-52. PMID 3327472 DOI: 10.1146/Annurev.Ge.21.120187.002233 |
0.3 |
|
| 1988 |
Keng T, Guarente L. Constitutive expression of the yeast HEM1 gene is actually a composite of activation and repression. Proceedings of the National Academy of Sciences of the United States of America. 84: 9113-7. PMID 3321068 DOI: 10.1073/Pnas.84.24.9113 |
0.365 |
|
| 1988 |
Buratowski S, Hahn S, Sharp PA, Guarente L. Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature. 334: 37-42. PMID 3290687 DOI: 10.1038/334037A0 |
0.348 |
|
| 1988 |
Chodosh LA, Olesen J, Hahn S, Baldwin AS, Guarente L, Sharp PA. A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell. 53: 25-35. PMID 3280141 DOI: 10.1016/0092-8674(88)90484-9 |
0.366 |
|
| 1988 |
Osborne BI, Guarente L. Transcription by RNA polymerase II induces changes of DNA topology in yeast. Genes & Development. 2: 766-72. PMID 3047008 DOI: 10.1101/Gad.2.6.766 |
0.381 |
|
| 1988 |
Guarente L. UASs and enhancers: common mechanism of transcriptional activation in yeast and mammals. Cell. 52: 303-5. PMID 2894251 DOI: 10.1016/S0092-8674(88)80020-5 |
0.348 |
|
| 1988 |
Hahn S, Guarente L. Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Science (New York, N.Y.). 240: 317-21. PMID 2832951 DOI: 10.1126/Science.2832951 |
0.371 |
|
| 1988 |
Hahn S, Pinkham J, Wei R, Miller R, Guarente L. The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts. Molecular and Cellular Biology. 8: 655-63. PMID 2832732 DOI: 10.1128/Mcb.8.2.655 |
0.406 |
|
| 1988 |
Forsburg SL, Guarente L. Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site. Molecular and Cellular Biology. 8: 647-54. PMID 2832731 DOI: 10.1128/Mcb.8.2.647 |
0.367 |
|
| 1988 |
Verdière J, Creusot F, Guarente L, Slonimski PP. The overproducing CYP1 and the underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes c. Current Genetics. 10: 339-42. PMID 2832070 DOI: 10.1007/Bf00418404 |
0.364 |
|
| 1987 |
Schneider JC, Guarente L. The untranslated header of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron Nucleic Acids Research. 15: 3515-3529. PMID 3033605 DOI: 10.1093/Nar/15.8.3515 |
0.36 |
|
| 1987 |
Pfeifer K, Arcangioli B, Guarente L. Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene. Cell. 49: 9-18. PMID 3030567 DOI: 10.1016/0092-8674(87)90750-1 |
0.338 |
|
| 1987 |
Pfeifer K, Prezant T, Guarente L. Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell. 49: 19-27. PMID 3030565 DOI: 10.1016/0092-8674(87)90751-3 |
0.345 |
|
| 1987 |
Lalonde B, Arcangioli B, Guarente L. A single Saccharomyces cerevisiae upstream activation site (UAS1) has two distinct regions essential for its activity. Molecular and Cellular Biology. 6: 4690-6. PMID 3025665 DOI: 10.1128/Mcb.6.12.4690 |
0.347 |
|
| 1987 |
Olesen J, Hahn S, Guarente L. Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner. Cell. 51: 953-961. PMID 2826015 DOI: 10.1016/0092-8674(87)90582-4 |
0.381 |
|
| 1987 |
Prezant T, Pfeifer K, Guarente L. Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation. Molecular and Cellular Biology. 7: 3252-9. PMID 2823123 DOI: 10.1128/Mcb.7.9.3252 |
0.372 |
|
| 1986 |
Pinkham JL, Guarente L. Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae. Molecular and Cellular Biology. 5: 3410-6. PMID 3915775 DOI: 10.1128/Mcb.5.12.3410 |
0.365 |
|
| 1986 |
Kim KS, Rosenkrantz MS, Guarente L. Saccharomyces cerevisiae contains two functional citrate synthase genes. Molecular and Cellular Biology. 6: 1936-42. PMID 3023912 DOI: 10.1128/Mcb.6.6.1936 |
0.376 |
|
| 1985 |
Guarente L, Hoar E. Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box". Proceedings of the National Academy of Sciences of the United States of America. 81: 7860-4. PMID 6096863 DOI: 10.1073/Pnas.81.24.7860 |
0.391 |
|
| 1985 |
Hahn S, Hoar ET, Guarente L. Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 82: 8562-8566. PMID 3001709 DOI: 10.1073/Pnas.82.24.8562 |
0.337 |
|
| 1984 |
Guarente L. Yeast promoters: positive and negative elements. Cell. 36: 799-800. PMID 6368004 DOI: 10.1016/0092-8674(84)90028-X |
0.402 |
|
| 1984 |
Guarente L, Lalonde B, Gifford P, Alani E. Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae Cell. 36: 503-511. PMID 6319028 DOI: 10.1016/0092-8674(84)90243-5 |
0.406 |
|
| 1984 |
Guarente L. Use of Gene Fusions to Study Biological Problems Genetic Engineering. 6: 233-251. DOI: 10.1007/978-1-4684-4793-4_12 |
0.394 |
|
| 1983 |
Michaelis S, Guarente L, Beckwith J. In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli Journal of Bacteriology. 154: 356-365. PMID 6403507 DOI: 10.1128/Jb.154.1.356-365.1983 |
0.586 |
|
| 1983 |
Guarente L. Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. Methods in Enzymology. 101: 181-91. PMID 6310321 DOI: 10.1016/0076-6879(83)01013-7 |
0.383 |
|
| 1983 |
Guarente L, Mason T. Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell. 32: 1279-86. PMID 6301690 DOI: 10.1016/0092-8674(83)90309-4 |
0.383 |
|
| 1982 |
Gray MR, Colot HV, Guarente L, Rosbash M. Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. Proceedings of the National Academy of Sciences of the United States of America. 79: 6598-602. PMID 6815653 DOI: 10.1073/Pnas.79.21.6598 |
0.346 |
|
| 1982 |
Guarente L, Yocum RR, Gifford P. A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site Proceedings of the National Academy of Sciences of the United States of America. 79: 7410-7414. PMID 6760197 DOI: 10.1073/Pnas.79.23.7410 |
0.374 |
|
| 1982 |
Guarente L, Nye JS, Hochschild A, Ptashne M. Mutant λ phage repressor with a specific defect in its positive control function Proceedings of the National Academy of Sciences of the United States of America. 79: 2236-2239. PMID 6212933 DOI: 10.1073/Pnas.79.7.2236 |
0.688 |
|
| 1981 |
Guarente L, Ptashne M. Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 78: 2199-2203. PMID 6264467 DOI: 10.1073/Pnas.78.4.2199 |
0.585 |
|
| 1980 |
Wu AM, Chapman AB, Platt T, Guarente LP, Beckwith J. Deletions of distal sequence affect termination of transcription at the end of the tryptophan operon in E. coli Cell. 19: 829-836. PMID 6991123 DOI: 10.1016/0092-8674(80)90073-2 |
0.549 |
|
| 1980 |
Guarente LP, Isberg RR, Syvanen M, Silhavy TJ. Conferral of transposable properties to a chromosomal gene in Escherichia coli. Journal of Molecular Biology. 141: 235-48. PMID 6253648 DOI: 10.1016/0022-2836(80)90179-5 |
0.487 |
|
| 1980 |
Guarente L, Lauer G, Roberts TM, Ptashne M. Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin Cell. 20: 543-553. PMID 6248249 DOI: 10.1016/0092-8674(80)90640-6 |
0.592 |
|
| 1980 |
Taniguchi T, Guarente L, Roberts TM, Kimelman D, Douhan J, Ptashne M. Expression of the human fibroblast interferon gene in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 77: 5230-5233. PMID 6159642 DOI: 10.1073/Pnas.77.9.5230 |
0.536 |
|
| 1980 |
Guarente L, Roberts TM, Ptashne M. A technique for expressing eukaryotic genes in bacteria. Science (New York, N.Y.). 209: 1428-30. PMID 6158095 DOI: 10.1126/Science.6158095 |
0.567 |
|
| 1980 |
Bassford P, Beckwith J, Berman M, Brickman E, Casadaban M, Guarente L, Saint-Girons I, Sarthy A, Schwartz M, Shuman H, Silhavy T. Genetic Fusions of the lac Operon: A New Approach to the Study of Biological Processes Cold Spring Harbor Monograph Archive. 7: 245-261. DOI: 10.1101/087969133.7.245 |
0.758 |
|
| 1979 |
Silhavy TJ, Brickman E, Bassford PJ, Casadaban MJ, Shuman HA, Schwartz V, Guarente L, Schwartz M, Beckwith JR. Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE,F,G operon. Molecular & General Genetics : Mgg. 174: 249-59. PMID 384167 DOI: 10.1007/BF00267797 |
0.743 |
|
| 1979 |
Guarente L. Restoration of termination by RNA polymerase mutations is rho allele-specific. Journal of Molecular Biology. 129: 295-304. PMID 383995 DOI: 10.1016/0022-2836(79)90283-3 |
0.302 |
|
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