Ron Firestein, Ph.D. - Publications

Affiliations: 
2002 Stanford University, Palo Alto, CA 
Area:
Toxoplasma

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sun CX, Daniel P, Bradshaw G, Shi H, Loi M, Chew N, Parackal S, Tsui V, Liang Y, Koptyra M, Adjumain S, Sun C, Chong WC, Fernando D, Drinkwater C, ... ... Firestein R, et al. Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities. Cancer Cell. PMID 37001527 DOI: 10.1016/j.ccell.2023.03.007  0.343
2022 Dicara DM, Bhakta S, Go MA, Ziai J, Firestein R, Forrest B, Gu C, Leong SR, Lee G, Yu SF, Polson AG, Agard NJ. Development of T-cell engagers selective for cells co-expressing two antigens. Mabs. 14: 2115213. PMID 36206404 DOI: 10.1080/19420862.2022.2115213  0.308
2021 Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, ... Firestein R, et al. MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase. Molecular Cell. PMID 34910943 DOI: 10.1016/j.molcel.2021.11.015  0.346
2018 Daemen A, Liu B, Song K, Kwong M, Gao M, Hong R, Nannini M, Peterson D, Liederer BM, de la Cruz C, Sangaraju D, Jaochico A, Zhao X, Sandoval W, Hunsaker T, ... Firestein R, et al. Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State. Cell Metabolism. PMID 30043751 DOI: 10.1016/J.Cmet.2018.06.003  0.442
2018 Raab M, Sanhaji M, Matthess Y, Hörlin A, Lorenz I, Dötsch C, Habbe N, Waidmann O, Kurunci-Csacsko E, Firestein R, Becker S, Strebhardt K. PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells. Nature Communications. 9: 1106. PMID 29549256 DOI: 10.1038/S41467-018-03494-4  0.447
2017 Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, et al. An anti-GDNF Family Receptor Alpha 1(GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer. Molecular Cancer Therapeutics. PMID 29282299 DOI: 10.1158/1535-7163.Mct-17-0813  0.458
2017 Mahara S, Firestein R. Targeting the seeds of small cell lung cancer. Annals of Translational Medicine. 5: 113. PMID 28361078 DOI: 10.21037/Atm.2017.01.74  0.501
2016 Liu JF, Moore KN, Birrer MJ, Berlin S, Matulonis UA, Infante JR, Wolpin B, Poon KA, Firestein R, Xu J, Kahn R, Wang Y, Wood K, Darbonne WC, Lackner MR, et al. Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 27: 2124-2130. PMID 27793850 DOI: 10.1093/Annonc/Mdw401  0.43
2016 Terwisscha van Scheltinga AG, Ogasawara A, Pacheco G, Vanderbilt A, Tinianow J, Gupta N, Li D, Firestein R, Marik J, Scales SJ, Williams SP. Preclinical Efficacy of an Antibody-Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET. Molecular Cancer Therapeutics. PMID 27760836 DOI: 10.1158/1535-7163.Mct-16-0449  0.454
2016 Boudreau A, Purkey HE, Hitz A, Robarge K, Peterson D, Labadie S, Kwong M, Hong R, Gao M, Del Nagro C, Pusapati R, Ma S, Salphati L, Pang J, Zhou A, ... ... Firestein R, et al. Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nature Chemical Biology. PMID 27479743 DOI: 10.1038/Nchembio.2143  0.371
2016 Williams SP, Ogasawara A, Tinianow JN, Flores JE, Kan D, Lau J, Go MA, Vanderbilt AN, Gill HS, Miao L, Goldsmith J, Rubinfeld B, Mao W, Firestein R, Yu SF, et al. ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1. Oncotarget. PMID 27029064 DOI: 10.18632/Oncotarget.8390  0.434
2016 Koehler MF, Bergeron P, Blackwood EM, Bowman K, Clark KR, Firestein R, Kiefer JR, Maskos K, McCleland ML, Orren L, Salphati L, Schmidt S, Schneider EV, Wu J, Beresini MH. Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. Acs Medicinal Chemistry Letters. 7: 223-8. PMID 26985305 DOI: 10.1021/Acsmedchemlett.5B00278  0.329
2016 McCleland ML, Mesh K, Lorenzana E, Chopra VS, Segal E, Watanabe C, Haley B, Mayba O, Yaylaoglu M, Gnad F, Firestein R. CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. The Journal of Clinical Investigation. PMID 26752646 DOI: 10.1172/Jci83265  0.472
2016 Firestein R, McCleland M, Mesh K, Gnad F. Abstract 406: Enhancer templated RNAs as predictors of therapeutic response to epigenetic therapy Cancer Research. 76: 406-406. DOI: 10.1158/1538-7445.Am2016-406  0.455
2015 Storm EE, Durinck S, de Sousa E Melo F, Tremayne J, Kljavin N, Tan C, Ye X, Chiu C, Pham T, Hongo JA, Bainbridge T, Firestein R, Blackwood E, Metcalfe C, Stawiski EW, et al. Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. Nature. PMID 26700806 DOI: 10.1038/Nature16466  0.404
2015 Junttila MR, Mao W, Wang X, Wang BE, Pham T, Flygare J, Yu SF, Yee S, Goldenberg D, Fields C, Eastham-Anderson J, Singh M, Vij R, Hongo JA, Firestein R, et al. Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer. Science Translational Medicine. 7: 314ra186. PMID 26582901 DOI: 10.1126/Scitranslmed.Aac7433  0.492
2015 McCleland ML, Soukup TM, Liu SD, Esensten JH, de Sousa E Melo F, Yaylaoglu M, Warming S, Roose-Girma M, Firestein R. Cdk8 deletion in the Apc(Min) murine tumor model represses EZH2 activity and accelerates tumorigenesis. The Journal of Pathology. PMID 26235356 DOI: 10.1002/Path.4596  0.404
2015 Lin K, Rubinfeld B, Zhang C, Firestein R, Harstad E, Roth L, Tsai SP, Schutten M, Xu K, Hristopoulos M, Polakis P. Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26156394 DOI: 10.1158/1078-0432.Ccr-14-3383  0.452
2015 Asundi J, Crocker L, Tremayne J, Chang P, Sakanaka C, Tanguay J, Spencer S, Chalasani S, Luis E, Gascoigne K, Desai R, Raja R, Friedman BA, Haverty PM, Polakis P, ... Firestein R, et al. An Antibody-Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 3252-62. PMID 25862760 DOI: 10.1158/1078-0432.Ccr-15-0156  0.388
2015 Leong SR, Liang WC, Wu Y, Crocker L, Cheng E, Sampath D, Ohri R, Raab H, Hass PE, Pham T, Firestein R, Li D, Schutten M, Stagg NJ, Ogasawara A, et al. An anti-b7-h4 antibody-drug conjugate for the treatment of breast cancer. Molecular Pharmaceutics. 12: 1717-29. PMID 25853436 DOI: 10.1021/Mp5007745  0.407
2015 Ryner L, Guan Y, Firestein R, Xiao Y, Choi Y, Rabe C, Lu S, Fuentes E, Huw LY, Lackner MR, Fu L, Amler LC, Bais C, Wang Y. Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2941-51. PMID 25838397 DOI: 10.1200/Jco.2015.33.15_Suppl.E16581  0.401
2015 Yu N, Kakunda M, Pham V, Lill JR, Du P, Wongchenko M, Yan Y, Firestein R, Huang X. HSP105 recruits protein phosphatase 2A to dephosphorylate β-catenin. Molecular and Cellular Biology. 35: 1390-400. PMID 25645927 DOI: 10.1128/Mcb.01307-14  0.315
2015 Wang Y, Firestein R, Ryner L, Darbonne W, Guan Y, Lu S, Choi Y, Xiao Y, Polakis P, Suttmann B, Desai R, Fu L, Saad O, Poon KA, Denker M, et al. Abstract POSTER-THER-1441: Biomarker evaluation of phase 1 clinical trials of antibody-drug conjugates (ADCs) in platinum resistant ovarian cancer Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Ovcasymp14-Poster-Ther-1441  0.454
2015 Asundi J, Crocker L, Tremayne J, Polakis P, Firestein R. Abstract 947: An antibody drug conjugate (ADC) directed to lymphocyte antigen 6 complex, locus E (LY6E) delivers targeted chemotherapy to a wide range of solid tumor malignancies Cancer Research. 75: 947-947. DOI: 10.1158/1538-7445.Am2015-947  0.499
2015 Danila DC, Scher HI, Szafer-Glusman E, Herkal A, Suttmann R, Fleisher M, Schreiber NA, Curtis K, Gilbert H, Maslyar D, Fine B, Firestein R, Mamounas M, Lackner MR, Kabbarah O. Abstract 4310: Predictive biomarkers of tumor sensitivity to STEAP1 antibody-drug conjugate (ADC) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) Cancer Research. 75: 4310-4310. DOI: 10.1158/1538-7445.Am2015-4310  0.419
2014 Shames D, Kowanetz M, Xiao Y, Choi Y, D'Arcangelo M, Behrens C, Solis LM, Koeppen H, Firestein R, Wang Y, Mocci S, Boyle TA, Lund-Iversen M, Bowden C, Amler LC, et al. 196PPREVALENCE, PROGNOSTIC SIGNIFICANCE, AND OVERLAP OF ACTIONABLE BIOMARKERS IN NSCLC. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 25: iv67. PMID 28172225 DOI: 10.1093/Annonc/Mdu326.30  0.392
2014 D'Arcangelo M, Brustugun OT, Xiao Y, Choi Y, Behrens C, Solis LM, Wang Y, Firestein R, Boyle TA, Lund-Iversen M, Rivard CJ, Helland Å, Wistuba I, Hirsch FR, Shames D. 194PPREVALENCE AND PROGNOSTIC SIGNIFICANCE OF SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2B (NAPI2B) PROTEIN EXPRESSION IN NON-SMALL CELL LUNG CANCER (NSCLC). Annals of Oncology : Official Journal of the European Society For Medical Oncology. 25: iv66-iv67. PMID 28170646 DOI: 10.1093/Annonc/Mdu326.28  0.399
2014 Scales SJ, Gupta N, Pacheco G, Firestein R, French DM, Koeppen H, Rangell L, Barry-Hamilton V, Luis E, Chuh J, Zhang Y, Ingle GS, Fourie-O'Donohue A, Kozak KR, Ross S, et al. An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models. Molecular Cancer Therapeutics. 13: 2630-40. PMID 25249555 DOI: 10.1158/1535-7163.Mct-14-0487-T  0.492
2014 Liu J, McCleland M, Stawiski EW, Gnad F, Mayba O, Haverty PM, Durinck S, Chen YJ, Klijn C, Jhunjhunwala S, Lawrence M, Liu H, Wan Y, Chopra V, Yaylaoglu MB, ... ... Firestein R, et al. Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. Nature Communications. 5: 3830. PMID 24807215 DOI: 10.1038/Ncomms4830  0.412
2014 Adler AS, McCleland ML, Yee S, Yaylaoglu M, Hussain S, Cosino E, Quinones G, Modrusan Z, Seshagiri S, Torres E, Chopra VS, Haley B, Zhang Z, Blackwood EM, Singh M, ... ... Firestein R, et al. An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth. Genes & Development. 28: 1068-84. PMID 24788092 DOI: 10.1101/Gad.237206.113  0.466
2014 Scales SJ, Gupta N, Pacheco G, Firestein R, French DM, Chuh J, Zhang Y, Berry L, Bostrom J, Luis E, O'Donohue AF, Kozak KR, Ross S, Dennis MS, Tibbitts J, et al. Abstract 4494: A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers Cancer Research. 74: 4494-4494. DOI: 10.1158/1538-7445.Am2014-4494  0.478
2013 Jaiswal BS, Kljavin NM, Stawiski EW, Chan E, Parikh C, Durinck S, Chaudhuri S, Pujara K, Guillory J, Edgar KA, Janakiraman V, Scholz RP, Bowman KK, Lorenzo M, Li H, ... ... Firestein R, et al. Oncogenic ERBB3 mutations in human cancers. Cancer Cell. 23: 603-17. PMID 23680147 DOI: 10.1016/J.Ccr.2013.04.012  0.419
2013 Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Research. 73: 3132-44. PMID 23539443 DOI: 10.1158/0008-5472.Can-12-4562  0.382
2013 McCleland ML, Adler AS, Deming L, Cosino E, Lee L, Blackwood EM, Solon M, Tao J, Li L, Shames D, Jackson E, Forrest WF, Firestein R. Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 773-84. PMID 23224736 DOI: 10.1158/1078-0432.Ccr-12-2638  0.344
2013 Boswell CA, Mundo EE, Firestein R, Zhang C, Mao W, Gill H, Young C, Ljumanovic N, Stainton S, Ulufatu S, Fourie A, Kozak KR, Fuji R, Polakis P, Khawli LA, et al. An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2. British Journal of Pharmacology. 168: 445-57. PMID 22889168 DOI: 10.1111/J.1476-5381.2012.02138.X  0.387
2013 Liu B, Song K, Kwong M, Gao M, Hong R, Nannini M, Sampath D, Belvin M, Peterson D, Evangelista M, Daemen A, Firestein R, Hatzivassiliou G. Abstract 4618: Elucidating the role of distinct glutaminase isoforms in cancer. Cancer Research. 73: 4618-4618. DOI: 10.1158/1538-7445.Am2013-4618  0.487
2013 Ryner L, Fourie A, Tsai SP, Scales S, Kozak K, Firestein R, Guan Y, Do A, Wang Y. Abstract 3213: A rapid, sensitive and quantitative method to measure protein biomarkers MUC16 and MSLN from archived clinical samples using TaqMan proximity ligation assays. Cancer Research. 73: 3213-3213. DOI: 10.1158/1538-7445.Am2013-3213  0.397
2013 Adler A, Jiang Z, McCleland M, Blackwood E, Yee S, Haley B, Stephan J, Hussain S, Chopra V, Firestein R. Abstract 3203: The tri-snRNP spliceosome complex is required for MYC-dependent cancer growth. Cancer Research. 73: 3203-3203. DOI: 10.1158/1538-7445.Am2013-3203  0.452
2012 McCleland ML, Adler AS, Shang Y, Hunsaker T, Truong T, Peterson D, Torres E, Li L, Haley B, Stephan JP, Belvin M, Hatzivassiliou G, Blackwood EM, Corson L, Evangelista M, ... ... Firestein R, et al. An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer. Cancer Research. 72: 5812-23. PMID 23139210 DOI: 10.1158/0008-5472.Can-12-1098  0.442
2012 Chen Y, Chalouni C, Tan C, Clark R, Venook R, Ohri R, Raab H, Firestein R, Mallet W, Polakis P. The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma. The Journal of Biological Chemistry. 287: 24082-91. PMID 22613716 DOI: 10.1074/Jbc.M112.361485  0.398
2012 Adler AS, McCleland ML, Truong T, Lau S, Modrusan Z, Soukup TM, Roose-Girma M, Blackwood EM, Firestein R. CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. Cancer Research. 72: 2129-39. PMID 22345154 DOI: 10.1158/0008-5472.Can-11-3886  0.463
2011 Asundi J, Reed C, Arca J, McCutcheon K, Ferrando R, Clark S, Luis E, Tien J, Firestein R, Polakis P. An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 965-75. PMID 21245091 DOI: 10.1158/1078-0432.Ccr-10-2340  0.432
2011 McCleland M, Adler A, Firestein R. Abstract 5191: Dual roles for CDK8 in cancer and stem cell maintenance Cancer Research. 71: 5191-5191. DOI: 10.1158/1538-7445.Am2011-5191  0.534
2010 Kim SY, Dunn IF, Firestein R, Gupta P, Wardwell L, Repich K, Schinzel AC, Wittner B, Silver SJ, Root DE, Boehm JS, Ramaswamy S, Lander ES, Hahn WC. CK1epsilon is required for breast cancers dependent on beta-catenin activity. Plos One. 5: e8979. PMID 20126544 DOI: 10.1371/Journal.Pone.0008979  0.398
2010 Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, Giovannucci EL, Hahn WC, Fuchs CS, Ogino S. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. International Journal of Cancer. Journal International Du Cancer. 126: 2863-73. PMID 19790197 DOI: 10.1002/Ijc.24908  0.438
2010 Mao W, Tien J, Goldenberg D, Stawicki S, Vij R, Xia X, Hongo J, Ross S, Kozak K, Firestein R, Wu Y, Spencer S, Polakis P. Abstract 4289: Early study on LGR5/GPR49 molecule as a potential colon cancer stem cell target for the antibody conjugated drug treatment Cancer Research. 70: 4289-4289. DOI: 10.1158/1538-7445.Am10-4289  0.516
2009 Firestein R, Hahn WC. Revving the Throttle on an oncogene: CDK8 takes the driver seat. Cancer Research. 69: 7899-901. PMID 19808961 DOI: 10.1158/0008-5472.Can-09-1704  0.363
2009 Nosho K, Shima K, Irahara N, Kure S, Firestein R, Baba Y, Toyoda S, Chen L, Hazra A, Giovannucci EL, Fuchs CS, Ogino S. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 22: 922-32. PMID 19430421 DOI: 10.1038/Modpathol.2009.49  0.437
2009 Hahn WC, Dunn IF, Kim SY, Schinzel AC, Firestein R, Guney I, Boehm JS. Integrative genomic approaches to understanding cancer. Biochimica Et Biophysica Acta. 1790: 478-84. PMID 19364473 DOI: 10.1016/J.Bbagen.2009.02.003  0.454
2008 Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 455: 547-51. PMID 18794900 DOI: 10.1038/Nature07179  0.431
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/Journal.Pone.0002020  0.443
2007 Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 129: 1065-79. PMID 17574021 DOI: 10.1016/J.Cell.2007.03.052  0.42
2002 Firestein R, Nagy PL, Daly M, Huie P, Conti M, Cleary ML. Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. The Journal of Clinical Investigation. 109: 1165-72. PMID 11994405 DOI: 10.1172/Jci12589  0.323
2000 Firestein R, Cui X, Huie P, Cleary ML. Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9. Molecular and Cellular Biology. 20: 4900-9. PMID 10848615 DOI: 10.1128/Mcb.20.13.4900-4909.2000  0.33
1998 Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML. Association of SET domain and myotubularin-related proteins modulates growth control. Nature Genetics. 18: 331-7. PMID 9537414 DOI: 10.1038/Ng0498-331  0.305
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