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Steven H. Kleinstein, Ph.D. - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Autoimmune Diseases; Computing Methodologies; Carcinoma, Hepatocellular; Immune System Diseases; Influenza Vaccines; Information Science; Leukemia; Lymphoma, Non-Hodgkin; Pattern Recognition, Automated; Virus Diseases; Computational Biology; Autoimmune Di
Website:
https://medicine.yale.edu/lab/kleinstein/people/steven_kleinstein-2.profile
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126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Jensen CG, Sumner JA, Kleinstein SH, Hoehn KB. Inferring B Cell Phylogenies from Paired H and L Chain BCR Sequences with Dowser. Journal of Immunology (Baltimore, Md. : 1950). PMID 38557795 DOI: 10.4049/jimmunol.2300851  0.595
2024 Ota M, Hoehn KB, Fernandes-Braga W, Ota T, Aranda CJ, Friedman S, Miranda-Waldetario MGC, Redes J, Suprun M, Grishina G, Sampson HA, Malbari A, Kleinstein SH, Sicherer SH, Curotto de Lafaille MA. CD23IgG1 memory B cells are poised to switch to pathogenic IgE production in food allergy. Science Translational Medicine. 16: eadi0673. PMID 38324641 DOI: 10.1126/scitranslmed.adi0673  0.639
2024 Gabernet G, Marquez S, Bjornson R, Peltzer A, Meng H, Aron E, Lee NY, Jensen C, Ladd D, Hanssen F, Heumos S, Yaari G, Kowarik MC, Nahnsen S, Kleinstein SH. nf-core/airrflow: an adaptive immune receptor repertoire analysis workflow employing the Immcantation framework. Biorxiv : the Preprint Server For Biology. PMID 38293151 DOI: 10.1101/2024.01.18.576147  0.315
2024 Callahan D, Smita S, Joachim S, Hoehn K, Kleinstein S, Weisel F, Chikina M, Shlomchik M. Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states. Nature Immunology. PMID 38200277 DOI: 10.1038/s41590-023-01721-9  0.714
2023 Hoehn KB, Kleinstein SH. B cell phylogenetics in the single cell era. Trends in Immunology. 45: 62-74. PMID 38151443 DOI: 10.1016/j.it.2023.11.004  0.682
2023 Jensen CG, Sumner JA, Kleinstein SH, Hoehn KB. Inferring B cell phylogenies from paired heavy and light chain BCR sequences with Dowser. Biorxiv : the Preprint Server For Biology. PMID 37873135 DOI: 10.1101/2023.09.29.560187  0.609
2023 Lopes de Assis F, Hoehn KB, Zhang X, Kardava L, Smith CD, El Merhebi O, Buckner CM, Trihemasava K, Wang W, Seamon CA, Chen V, Schaughency P, Cheung F, Martins AJ, Chiang CI, ... ... Kleinstein SH, et al. Tracking B cell responses to the SARS-CoV-2 mRNA-1273 vaccine. Cell Reports. 42: 112780. PMID 37440409 DOI: 10.1016/j.celrep.2023.112780  0.628
2023 Jiang R, Roy B, Wu Q, Mohanty S, Nowak RJ, Shaw AC, Kleinstein SH, O'Connor KC. The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties. Immunohorizons. 7: 310-322. PMID 37171806 DOI: 10.4049/immunohorizons.2200078  0.354
2023 Nickerson KM, Smita S, Hoehn KB, Marinov AD, Thomas KB, Kos JT, Yang Y, Bastacky SI, Watson CT, Kleinstein SH, Shlomchik MJ. Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice. The Journal of Experimental Medicine. 220. PMID 36828389 DOI: 10.1084/jem.20221346  0.729
2023 Ota M, Hoehn KB, Ota T, Aranda CJ, Friedman S, Braga WF, Malbari A, Kleinstein SH, Sicherer SH, Curotto de Lafaille MA. The memory of pathogenic IgE is contained within CD23 IgG1 memory B cells poised to switch to IgE in food allergy. Biorxiv : the Preprint Server For Biology. PMID 36747707 DOI: 10.1101/2023.01.25.525506  0.615
2022 Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, ... ... Kleinstein SH, et al. PD-1CXCR5CD4 peripheral helper T cells promote CXCR3 plasmablasts in human acute viral infection. Cell Reports. 111895. PMID 36596303 DOI: 10.1016/j.celrep.2022.111895  0.643
2022 Xu Q, Milanez-Almeida P, Martins AJ, Radtke AJ, Hoehn KB, Oguz C, Chen J, Liu C, Tang J, Grubbs G, Stein S, Ramelli S, Kabat J, Behzadpour H, Karkanitsa M, ... ... Kleinstein SH, et al. Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children. Nature Immunology. PMID 36536106 DOI: 10.1038/s41590-022-01367-z  0.629
2022 Fichtner ML, Hoehn KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, O'Connor KC. Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Acta Neuropathologica Communications. 10: 154. PMID 36307868 DOI: 10.1186/s40478-022-01454-0  0.645
2022 Hoehn KB, Pybus OG, Kleinstein SH. Phylogenetic analysis of migration, differentiation, and class switching in B cells. Plos Computational Biology. 18: e1009885. PMID 35468128 DOI: 10.1371/journal.pcbi.1009885  0.645
2022 Manthiram K, Xu Q, Milanez-Almeida P, Martins A, Radtke A, Hoehn K, Chen J, Liu C, Tang J, Grubbs G, Stein S, Ramelli S, Kabat J, Behzadpour H, Karkanitsa M, ... ... Kleinstein S, et al. Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children. Research Square. PMID 35350206 DOI: 10.21203/rs.3.rs-1276578/v1  0.622
2022 Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, ... ... Kleinstein SH, et al. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nature Communications. 13: 440. PMID 35064122 DOI: 10.1038/s41467-021-27716-4  0.66
2021 Hoehn KB, Turner JS, Miller FI, Jiang R, Pybus OG, Ali Ellebedy D, Kleinstein SH. Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving. Elife. 10. PMID 34787567 DOI: 10.7554/eLife.70873  0.564
2021 Ohm-Laursen L, Meng H, Hoehn KB, Nouri N, Jiang Y, Clouser C, Johnstone TG, Hause R, Sandhar BS, Upton NEG, Chevretton EB, Lakhani R, Corrigan CJ, Kleinstein SH, Gould HJ. B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma. Frontiers in Immunology. 12: 702074. PMID 34721376 DOI: 10.3389/fimmu.2021.702074  0.63
2021 Mandel-Brehm C, Fichtner ML, Jiang R, Winton VJ, Vazquez SE, Pham MC, Hoehn KB, Kelleher NL, Nowak RJ, Kleinstein SH, Wilson MR, DeRisi JL, O'Connor KC. Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes. Journal of Immunology (Baltimore, Md. : 1950). PMID 34544801 DOI: 10.4049/jimmunol.2100225  0.593
2021 Brioschi S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ, Bando JK, Jaeger N, Czepielewski RS, Swain A, Mogilenko DA, Beatty WL, Bayguinov P, Fitzpatrick JAJ, Schuettpelz LG, ... ... Kleinstein SH, et al. Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science (New York, N.Y.). PMID 34083450 DOI: 10.1126/science.abf9277  0.365
2021 Jiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells. Jci Insight. PMID 34061047 DOI: 10.1172/jci.insight.148035  0.656
2021 Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19. Journal of Immunology (Baltimore, Md. : 1950). PMID 34049971 DOI: 10.4049/jimmunol.2100135  0.657
2021 Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, ... ... Kleinstein SH, et al. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity. PMID 33891889 DOI: 10.1016/j.immuni.2021.04.003  0.578
2021 Lu Y, Jiang R, Freyn AW, Wang J, Strohmeier S, Lederer K, Locci M, Zhao H, Angeletti D, O'Connor KC, Kleinstein SH, Nachbagauer R, Craft J. CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response. The Journal of Experimental Medicine. 218. PMID 33326020 DOI: 10.1084/jem.20200547  0.371
2020 Lindenbaum O, Nouri N, Kluger Y, Kleinstein SH. Alignment free identification of clones in B cell receptor repertoires. Nucleic Acids Research. PMID 33330933 DOI: 10.1093/nar/gkaa1160  0.311
2020 Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, ... ... Kleinstein SH, et al. Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity. Medrxiv : the Preprint Server For Health Sciences. PMID 33300011 DOI: 10.1101/2020.12.01.20241364  0.58
2020 Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Proceedings of the National Academy of Sciences of the United States of America. PMID 33199596 DOI: 10.1073/pnas.2007206117  0.646
2020 Song E, Chow RD, Jiang R, Zamecnik CR, Loudermilk RP, Dai Y, Liu F, Geng B, Chiarella J, Israelow B, Casanovas-Massana A, Ko AI, Ring A, Kleinstein SH, Spudich S, et al. Immunologically distinct responses occur in the CNS of COVID-19 patients. Biorxiv : the Preprint Server For Biology. PMID 32935102 DOI: 10.1101/2020.09.11.293464  0.305
2020 Turner JS, Zhou JQ, Han J, Schmitz AJ, Rizk AA, Alsoussi WB, Lei T, Amor M, McIntire KM, Meade P, Strohmeier S, Brent RI, Richey ST, Haile A, Yang YR, ... ... Kleinstein SH, et al. Human germinal centres engage memory and naive B cells after influenza vaccination. Nature. PMID 32866963 DOI: 10.1038/S41586-020-2711-0  0.406
2020 Alsoussi WB, Turner JS, Case JB, Zhao H, Schmitz AJ, Zhou JQ, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, ... ... Kleinstein SH, et al. A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 32591393 DOI: 10.4049/Jimmunol.2000583  0.356
2020 Nouri N, Kleinstein SH. Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data. Plos Computational Biology. 16: e1007977. PMID 32574157 DOI: 10.1371/Journal.Pcbi.1007977  0.485
2020 Jiang R, Fichtner ML, Hoehn KB, Pham MC, Stathopoulos P, Nowak RJ, Kleinstein SH, O'Connor KC. Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses. Jci Insight. PMID 32573488 DOI: 10.1172/Jci.Insight.136471  0.684
2020 Béguelin W, Teater M, Meydan C, Hoehn KB, Phillip JM, Soshnev AA, Venturutti L, Rivas MA, Calvo-Fernández MT, Gutierrez J, Camarillo JM, Takata K, Tarte K, Kelleher NL, Steidl C, ... ... Kleinstein SH, et al. Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response. Cancer Cell. 37: 655-673.e11. PMID 32396861 DOI: 10.1016/J.Ccell.2020.04.004  0.668
2020 Vita R, Overton JA, Dunn P, Cheung KH, Kleinstein SH, Sette A, Peters B. A structured model for immune exposures. Database : the Journal of Biological Databases and Curation. 2020. PMID 32283555 DOI: 10.1093/Database/Baaa016  0.333
2020 Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, ... ... Kleinstein SH, et al. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. Plos Neglected Tropical Diseases. 14: e0008112. PMID 32150565 DOI: 10.1371/Journal.Pntd.0008112  0.399
2019 Austin JW, Buckner CM, Kardava L, Wang W, Zhang X, Melson VA, Swanson RG, Martins AJ, Zhou JQ, Hoehn KB, Fisk JN, Dimopoulos Y, Chassiakos A, O'Dell S, Smelkinson MG, ... ... Kleinstein SH, et al. Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation. Science Translational Medicine. 11. PMID 31776286 DOI: 10.1126/Scitranslmed.Aax0904  0.649
2019 Hoehn KB, Vander Heiden JA, Zhou JQ, Lunter G, Pybus OG, Kleinstein SH. Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination. Proceedings of the National Academy of Sciences of the United States of America. PMID 31636219 DOI: 10.1073/Pnas.1906020116  0.661
2019 Zhou JQ, Kleinstein SH. Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships. Journal of Immunology (Baltimore, Md. : 1950). PMID 31484734 DOI: 10.4049/Jimmunol.1900666  0.336
2019 Fraussen J, Marquez S, Takata K, Beckers L, Montes Diaz G, Zografou C, Van Wijmeersch B, Villar LM, O'Connor KC, Kleinstein SH, Somers V. Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgDCD27 Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients. Journal of Immunology (Baltimore, Md. : 1950). PMID 31391234 DOI: 10.4049/Jimmunol.1801236  0.477
2019 Overton JA, Vita R, Dunn P, Burel JG, Bukhari SAC, Cheung KH, Kleinstein SH, Diehl AD, Peters B. Reporting and connecting cell type names and gating definitions through ontologies. Bmc Bioinformatics. 20: 182. PMID 31272390 DOI: 10.1186/S12859-019-2725-5  0.351
2019 Oh JE, Iijima N, Song E, Lu P, Klein J, Jiang R, Kleinstein SH, Iwasaki A. Migrant memory B cells secrete luminal antibody in the vagina. Nature. PMID 31189952 DOI: 10.1038/S41586-019-1285-1  0.424
2019 Cotzomi E, Stathopoulos P, Lee CS, Ritchie AM, Soltys JN, Delmotte FR, Oe T, Sng J, Jiang R, Ma AK, Vander Heiden JA, Kleinstein SH, Levy M, Bennett JL, Meffre E, et al. Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production. Brain : a Journal of Neurology. PMID 31056665 DOI: 10.1093/Brain/Awz106  0.427
2019 Ohlin M, Scheepers C, Corcoran M, Lees WD, Busse CE, Bagnara D, Thörnqvist L, Bürckert JP, Jackson KJL, Ralph D, Schramm CA, Marthandan N, Breden F, Scott J, Matsen Iv FA, ... ... Kleinstein SH, et al. Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming. Frontiers in Immunology. 10: 435. PMID 30936866 DOI: 10.3389/Fimmu.2019.00435  0.394
2019 Gadala-Maria D, Gidoni M, Marquez S, Vander Heiden JA, Kos JT, Watson CT, O'Connor KC, Yaari G, Kleinstein SH. Identification of Subject-Specific Immunoglobulin Alleles From Expressed Repertoire Sequencing Data. Frontiers in Immunology. 10: 129. PMID 30814994 DOI: 10.3389/Fimmu.2019.00129  0.376
2018 Vander Heiden JA, Marquez S, Marthandan N, Bukhari SAC, Busse CE, Corrie B, Hershberg U, Kleinstein SH, Matsen Iv FA, Ralph DK, Rosenfeld AM, Schramm CA, Christley S, Laserson U. AIRR Community Standardized Representations for Annotated Immune Repertoires. Frontiers in Immunology. 9: 2206. PMID 30323809 DOI: 10.3389/Fimmu.2018.02206  0.689
2018 Rydyznski CE, Cranert SA, Zhou JQ, Xu H, Kleinstein SH, Singh H, Waggoner SN. Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers. Cell Reports. 24: 3367-3373.e4. PMID 30257198 DOI: 10.1016/J.Celrep.2018.08.075  0.456
2018 Ohm-Laursen L, Meng H, Chen J, Zhou JQ, Corrigan CJ, Gould HJ, Kleinstein SH. Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa. Frontiers in Immunology. 9: 1976. PMID 30245687 DOI: 10.3389/Fimmu.2018.01976  0.49
2018 Zhao Y, Uduman M, Siu JHY, Tull TJ, Sanderson JD, Wu YB, Zhou JQ, Petrov N, Ellis R, Todd K, Chavele KM, Guesdon W, Vossenkamper A, Jassem W, D'Cruz DP, ... ... Kleinstein SH, et al. Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue. Nature Communications. 9: 3857. PMID 30242242 DOI: 10.1038/S41467-018-06089-1  0.445
2018 Bukhari SAC, O'Connor MJ, Martínez-Romero M, Egyedi AL, Willrett D, Graybeal J, Musen MA, Rubelt F, Cheung KH, Kleinstein SH. The CAIRR Pipeline for Submitting Standards-Compliant B and T Cell Receptor Repertoire Sequencing Studies to the National Center for Biotechnology Information Repositories. Frontiers in Immunology. 9: 1877. PMID 30166985 DOI: 10.3389/Fimmu.2018.01877  0.412
2018 Nouri N, Kleinstein SH. Optimized Threshold Inference for Partitioning of Clones From High-Throughput B Cell Repertoire Sequencing Data. Frontiers in Immunology. 9: 1687. PMID 30093903 DOI: 10.3389/Fimmu.2018.01687  0.443
2018 Nouri N, Kleinstein SH. A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data. Bioinformatics (Oxford, England). 34: i341-i349. PMID 29949968 DOI: 10.1093/bioinformatics/bty235  0.324
2017 Breden F, Luning Prak ET, Peters B, Rubelt F, Schramm CA, Busse CE, Vander Heiden JA, Christley S, Bukhari SAC, Thorogood A, Matsen Iv FA, Wine Y, Laserson U, Klatzmann D, Douek DC, ... ... Kleinstein SH, et al. Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data. Frontiers in Immunology. 8: 1418. PMID 29163494 DOI: 10.3389/Fimmu.2017.01418  0.377
2017 Rubelt F, Busse CE, Bukhari SAC, Bürckert JP, Mariotti-Ferrandiz E, Cowell LG, Watson CT, Marthandan N, Faison WJ, Hershberg U, Laserson U, Corrie BD, Davis MM, Peters B, Lefranc MP, ... ... Kleinstein SH, et al. Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data. Nature Immunology. 18: 1274-1278. PMID 29144493 DOI: 10.1038/Ni.3873  0.698
2017 Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. Interleukin-10 from CD4(+) follicular regulatory T cells promotes the germinal center response. Science Immunology. 2. PMID 29054998 DOI: 10.1126/Sciimmunol.Aan4767  0.414
2017 Avey S, Mohanty S, Wilson J, Zapata H, Joshi SR, Siconolfi B, Tsang S, Shaw AC, Kleinstein SH. Multiple network-constrained regressions expand insights into influenza vaccination responses. Bioinformatics (Oxford, England). 33: i208-i216. PMID 28881994 DOI: 10.1093/Bioinformatics/Btx260  0.327
2017 Watson CT, Matsen FA, Jackson KJL, Bashir A, Smith ML, Glanville J, Breden F, Kleinstein SH, Collins AM, Busse CE. Comment on "A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data". Journal of Immunology (Baltimore, Md. : 1950). 198: 3371-3373. PMID 28416712 DOI: 10.4049/Jimmunol.1700306  0.322
2017 Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8(+) T Cell Terminal Differentiation and Loss of Multipotency. Immunity. PMID 28410989 DOI: 10.1016/J.Immuni.2017.03.012  0.387
2017 Gupta NT, Adams KD, Briggs AW, Timberlake SC, Vigneault F, Kleinstein SH. Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data. Journal of Immunology (Baltimore, Md. : 1950). PMID 28179494 DOI: 10.4049/Jimmunol.1601850  0.398
2017 Vander Heiden JA, Stathopoulos P, Zhou JQ, Chen L, Gilbert TJ, Bolen CR, Barohn RJ, Dimachkie MM, Ciafaloni E, Broering TJ, Vigneault F, Nowak RJ, Kleinstein SH, O'Connor KC. Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing. Journal of Immunology (Baltimore, Md. : 1950). PMID 28087666 DOI: 10.4049/Jimmunol.1601415  0.422
2016 Toby IT, Levin MK, Salinas EA, Christley S, Bhattacharya S, Breden F, Buntzman A, Corrie B, Fonner J, Gupta NT, Hershberg U, Marthandan N, Rosenfeld A, Rounds W, Rubelt F, ... ... Kleinstein SH, et al. VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements. Bmc Bioinformatics. 17: 333. PMID 27766961 DOI: 10.1186/S12859-016-1214-3  0.692
2016 Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH. A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. Journal of Immunology (Baltimore, Md. : 1950). PMID 27707999 DOI: 10.4049/Jimmunol.1502263  0.592
2016 Bohannon C, Powers R, Satyabhama L, Cui A, Tipton C, Michaeli M, Skountzou I, Mittler RS, Kleinstein SH, Mehr R, Lee FE, Sanz I, Jacob J. Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection. Nature Communications. 7: 12687. PMID 27527920 DOI: 10.1038/Ncomms12687  0.353
2016 Donius LR, Cheng Y, Choi J, Sun ZJ, Hanson M, Zhang M, Gierahn TM, Marquez S, Uduman M, Kleinstein SH, Irvine D, Love JC, Reinherz EL, Kim M. Generation of long-lived bone marrow plasma cells secreting antibodies specific for HIV-1 gp41 MPER in the absence of polyreactivity. Journal of Virology. PMID 27466419 DOI: 10.1128/Jvi.01089-16  0.4
2016 Maman Y, Teng G, Seth R, Kleinstein SH, Schatz DG. RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2. Nucleic Acids Research. PMID 27436288 DOI: 10.1093/Nar/Gkw633  0.322
2016 Hudnall SD, Meng H, Lozovatsky L, Li P, Strout M, Kleinstein SH. Recurrent genetic defects in classical Hodgkin lymphoma cell lines. Leukemia & Lymphoma. 1-11. PMID 27121023 DOI: 10.1080/10428194.2016.1177179  0.342
2016 Rubelt F, Bolen CR, McGuire HM, Heiden JA, Gadala-Maria D, Levin M, M Euskirchen G, Mamedov MR, Swan GE, Dekker CL, Cowell LG, Kleinstein SH, Davis MM. Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells. Nature Communications. 7: 11112. PMID 27005435 DOI: 10.1038/Ncomms11112  0.41
2016 Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC. Characterization of diabetogenic CD8+ T cells: immune therapy with metabolic blockade. The Journal of Biological Chemistry. PMID 26994137 DOI: 10.1074/Jbc.M115.713362  0.398
2016 Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ, O'Connor KC. Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production. Journal of Immunology (Baltimore, Md. : 1950). PMID 26826242 DOI: 10.4049/Jimmunol.1501339  0.411
2015 Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, et al. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. PMID 26605525 DOI: 10.1038/Nature16074  0.386
2015 Yaari G, Kleinstein SH. Practical guidelines for B-cell receptor repertoire sequencing analysis. Genome Medicine. 7: 121. PMID 26589402 DOI: 10.1186/S13073-015-0243-2  0.454
2015 Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, Kleinstein SH, Kaech SM. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. The Journal of Experimental Medicine. PMID 26503446 DOI: 10.1084/Jem.20150186  0.335
2015 Tsioris K, Gupta NT, Ogunniyi AO, Zimnisky RM, Qian F, Yao Y, Wang X, Stern JN, Chari R, Briggs AW, Clouser CR, Vigneault F, Church GM, Garcia MN, Murray KO, ... ... Kleinstein SH, et al. Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 1587-97. PMID 26481611 DOI: 10.1039/C5Ib00169B  0.445
2015 Gorenshteyn D, Zaslavsky E, Fribourg M, Park CY, Wong AK, Tadych A, Hartmann BM, Albrecht RA, García-Sastre A, Kleinstein SH, Troyanskaya OG, Sealfon SC. Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases. Immunity. 43: 605-14. PMID 26362267 DOI: 10.1016/J.Immuni.2015.08.014  0.33
2015 Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. PMID 26321681 DOI: 10.1016/J.Cell.2015.08.012  0.318
2015 Thakar J, Hartmann BM, Marjanovic N, Sealfon SC, Kleinstein SH. Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism. Bmc Immunology. 16: 46. PMID 26272204 DOI: 10.1186/S12865-015-0107-Y  0.35
2015 Hartmann BM, Thakar J, Albrecht RA, Avey S, Zaslavsky E, Marjanovic N, Chikina M, Fribourg M, Hayot F, Schmolke M, Meng H, Wetmur J, García-Sastre A, Kleinstein SH, Sealfon SC. Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses. Journal of Virology. 89: 10190-205. PMID 26223639 DOI: 10.1128/Jvi.01523-15  0.3
2015 Yaari G, Benichou JI, Vander Heiden JA, Kleinstein SH, Louzoun Y. The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26194756 DOI: 10.1098/Rstb.2014.0242  0.459
2015 Di Niro R, Lee SJ, Vander Heiden JA, Elsner RA, Trivedi N, Bannock JM, Gupta NT, Kleinstein SH, Vigneault F, Gilbert TJ, Meffre E, McSorley SJ, Shlomchik MJ. Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation. Immunity. 43: 120-31. PMID 26187411 DOI: 10.1016/J.Immuni.2015.06.013  0.639
2015 Di Niro R, Snir O, Kaukinen K, Yaari G, Lundin KE, Gupta NT, Kleinstein SH, Cols M, Cerutti A, Mäki M, Shlomchik MJ, Sollid LM. Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. Mucosal Immunology. PMID 26153762 DOI: 10.1038/Mi.2015.57  0.601
2015 Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nature Immunology. PMID 26147684 DOI: 10.1038/Ni.3224  0.348
2015 Gupta NT, Vander Heiden JA, Uduman M, Gadala-Maria D, Yaari G, Kleinstein SH. Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data. Bioinformatics (Oxford, England). 31: 3356-8. PMID 26069265 DOI: 10.1093/Bioinformatics/Btv359  0.382
2015 Rakoff-Nahoum S, Kong Y, Kleinstein SH, Subramanian S, Ahern PP, Gordon JI, Medzhitov R. Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Proceedings of the National Academy of Sciences of the United States of America. 112: 1929-36. PMID 25691701 DOI: 10.1073/Pnas.1424886112  0.307
2015 Gadala-Maria D, Yaari G, Uduman M, Kleinstein SH. Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles. Proceedings of the National Academy of Sciences of the United States of America. 112: E862-70. PMID 25675496 DOI: 10.1073/Pnas.1417683112  0.393
2015 Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, ... Kleinstein SH, et al. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clinical and Vaccine Immunology : Cvi. 22: 6-16. PMID 25355795 DOI: 10.1128/Cvi.00508-14  0.353
2014 Wu YC, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ. Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis. The Journal of Allergy and Clinical Immunology. 134: 604-12. PMID 25171866 DOI: 10.1016/J.Jaci.2014.07.010  0.316
2014 Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, et al. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine. 6: 248ra107. PMID 25100741 DOI: 10.1126/Scitranslmed.3008879  0.452
2014 Cho MJ, Lo AS, Mao X, Nagler AR, Ellebrecht CT, Mukherjee EM, Hammers CM, Choi EJ, Sharma PM, Uduman M, Li H, Rux AH, Farber SA, Rubin CB, Kleinstein SH, et al. Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients. Nature Communications. 5: 4167. PMID 24942562 DOI: 10.1038/Ncomms5167  0.366
2014 Zuccarino-Catania GV, Sadanand S, Weisel FJ, Tomayko MM, Meng H, Kleinstein SH, Good-Jacobson KL, Shlomchik MJ. CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nature Immunology. 15: 631-7. PMID 24880458 DOI: 10.1038/Ni.2914  0.569
2014 Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 192: 4221-32. PMID 24659688 DOI: 10.4049/Jimmunol.1302569  0.371
2014 Laserson U, Vigneault F, Gadala-Maria D, Yaari G, Uduman M, Vander Heiden JA, Kelton W, Taek Jung S, Liu Y, Laserson J, Chari R, Lee JH, Bachelet I, Hickey B, Lieberman-Aiden E, ... ... Kleinstein SH, et al. High-resolution antibody dynamics of vaccine-induced immune responses. Proceedings of the National Academy of Sciences of the United States of America. 111: 4928-33. PMID 24639495 DOI: 10.1073/Pnas.1323862111  0.382
2014 Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics (Oxford, England). 30: 1930-2. PMID 24618469 DOI: 10.1093/Bioinformatics/Btu138  0.366
2014 Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunology. 27: 39-47. PMID 24605787 DOI: 10.1089/Vim.2013.0074  0.333
2014 Uduman M, Shlomchik MJ, Vigneault F, Church GM, Kleinstein SH. Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences. Journal of Immunology (Baltimore, Md. : 1950). 192: 867-74. PMID 24376267 DOI: 10.4049/Jimmunol.1301551  0.611
2014 Katz SG, Labelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood. 123: 884-93. PMID 24352880 DOI: 10.1182/Blood-2013-04-499079  0.397
2014 Xi Y, Shivarov V, Yaari G, Kleinstein S, Strout MP. DNA Demethylation By Activation-Induced Cytidine Deaminase in B Cell Lymphoma Blood. 124: 3549-3549. DOI: 10.1182/Blood.V124.21.3549.3549  0.381
2013 Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Frontiers in Immunology. 4: 358. PMID 24298272 DOI: 10.3389/Fimmu.2013.00358  0.425
2013 Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM, O'Connor KC. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro-Oncology. 15: 1479-90. PMID 23978377 DOI: 10.1093/Neuonc/Not110  0.471
2013 Thakar J, Schmid S, Duke JL, García-Sastre A, Kleinstein SH. Overcoming NS1-mediated immune antagonism involves both interferon-dependent and independent mechanisms. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 33: 700-8. PMID 23772952 DOI: 10.1089/Jir.2012.0113  0.318
2013 Zaslavsky E, Nudelman G, Marquez S, Hershberg U, Hartmann BM, Thakar J, Sealfon SC, Kleinstein SH. Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. Bmc Bioinformatics. 14: S1. PMID 23734902 DOI: 10.1186/1471-2105-14-S6-S1  0.64
2013 Bryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, et al. Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. The Journal of Allergy and Clinical Immunology. 132: 170-81. PMID 23727037 DOI: 10.1016/J.Jaci.2013.04.048  0.371
2013 Duke JL, Liu M, Yaari G, Khalil AM, Tomayko MM, Shlomchik MJ, Schatz DG, Kleinstein SH. Multiple transcription factor binding sites predict AID targeting in non-Ig genes. Journal of Immunology (Baltimore, Md. : 1950). 190: 3878-88. PMID 23514741 DOI: 10.4049/Jimmunol.1202547  0.559
2012 Kohler KM, McDonald JJ, Duke JL, Arakawa H, Tan S, Kleinstein SH, Buerstedde JM, Schatz DG. Identification of core DNA elements that target somatic hypermutation. Journal of Immunology (Baltimore, Md. : 1950). 189: 5314-26. PMID 23087403 DOI: 10.4049/Jimmunol.1202082  0.376
2012 Yaari G, Uduman M, Kleinstein SH. Quantifying selection in high-throughput Immunoglobulin sequencing data sets. Nucleic Acids Research. 40: e134. PMID 22641856 DOI: 10.1093/Nar/Gks457  0.457
2012 Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, et al. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 484: 510-3. PMID 22538615 DOI: 10.1038/Nature11012  0.396
2011 Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity. 35: 633-46. PMID 22018471 DOI: 10.1016/J.Immuni.2011.08.016  0.372
2011 Costa KD, Kleinstein SH, Hershberg U. Biomedical model fitting and error analysis. Science Signaling. 4: tr9. PMID 21954296 DOI: 10.1126/Scisignal.2001983  0.637
2011 O'Connor MJ, Hauser AE, Haberman AM, Kleinstein SH. Activated germinal centre B cells undergo directed migration. International Journal of Data Mining and Bioinformatics. 5: 321-31. PMID 21805826 DOI: 10.1504/IJDMB.2011.040387  0.376
2011 Bolen CR, Uduman M, Kleinstein SH. Cell subset prediction for blood genomic studies. Bmc Bioinformatics. 12: 258. PMID 21702940 DOI: 10.7490/F1000Research.1092197.1  0.373
2011 Uduman M, Yaari G, Hershberg U, Stern JA, Shlomchik MJ, Kleinstein SH. Detecting selection in immunoglobulin sequences. Nucleic Acids Research. 39: W499-504. PMID 21665923 DOI: 10.1093/Nar/Gkr413  0.743
2011 Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, Kleinstein SH, Haberman AM. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity. 34: 947-60. PMID 21636295 DOI: 10.1016/J.Immuni.2011.03.024  0.441
2011 Cohen RM, Kleinstein SH, Louzoun Y. Somatic hypermutation targeting is influenced by location within the immunoglobulin V region. Molecular Immunology. 48: 1477-83. PMID 21592579 DOI: 10.1016/J.Molimm.2011.04.002  0.372
2011 Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 4: 530-43. PMID 21321062 DOI: 10.1158/1940-6207.Capr-10-0143  0.32
2010 Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. Plos One. 5: e11502. PMID 20634979 DOI: 10.1371/Journal.Pone.0011502  0.316
2010 Nudelman G, Ge Y, Hu J, Kumar M, Seto J, Duke JL, Kleinstein SH, Hayot F, Sealfon SC, Wetmur JG. Coregulation mapping based on individual phenotypic variation in response to virus infection. Immunome Research. 6: 2. PMID 20298589 DOI: 10.1186/1745-7580-6-2  0.323
2010 Zaslavsky E, Hershberg U, Seto J, Pham AM, Marquez S, Duke JL, Wetmur JG, Tenoever BR, Sealfon SC, Kleinstein SH. Antiviral response dictated by choreographed cascade of transcription factors. Journal of Immunology (Baltimore, Md. : 1950). 184: 2908-17. PMID 20164420 DOI: 10.4049/Jimmunol.0903453  0.685
2009 Anderson SM, Khalil A, Uduman M, Hershberg U, Louzoun Y, Haberman AM, Kleinstein SH, Shlomchik MJ. Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 7314-25. PMID 19917681 DOI: 10.4049/Jimmunol.0902452  0.767
2009 Bruno VM, Hannemann S, Lara-Tejero M, Flavell RA, Kleinstein SH, Galán JE. Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. Plos Pathogens. 5: e1000538. PMID 19662166 DOI: 10.1371/Journal.Ppat.1000538  0.35
2008 Kleinstein SH. Getting started in computational immunology. Plos Computational Biology. 4: e1000128. PMID 18769677 DOI: 10.1371/Journal.Pcbi.1000128  0.452
2008 Hershberg U, Uduman M, Shlomchik MJ, Kleinstein SH. Improved methods for detecting selection by mutation analysis of Ig V region sequences. International Immunology. 20: 683-94. PMID 18397909 DOI: 10.1093/Intimm/Dxn026  0.744
2008 Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, Kleinstein SH, Schatz DG. Two levels of protection for the B cell genome during somatic hypermutation. Nature. 451: 841-5. PMID 18273020 DOI: 10.1038/Nature06547  0.444
2007 Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity. 26: 655-67. PMID 17509908 DOI: 10.1016/J.Immuni.2007.04.008  0.63
2006 Magori-Cohen R, Louzoun Y, Kleinstein SH. Mutation parameters from DNA sequence data using graph theoretic measures on lineage trees. Bioinformatics (Oxford, England). 22: e332-40. PMID 16873490 DOI: 10.1093/Bioinformatics/Btl239  0.425
2003 Kleinstein SH, Louzoun Y, Shlomchik MJ. Estimating hypermutation rates from clonal tree data. Journal of Immunology (Baltimore, Md. : 1950). 171: 4639-49. PMID 14568938 DOI: 10.4049/Jimmunol.171.9.4639  0.561
2003 Kleinstein SH, Singh JP. Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center. International Immunology. 15: 871-84. PMID 12807826 DOI: 10.1093/Intimm/Dxg085.Sgm  0.55
2001 Kleinstein SH, Singh JP. Toward quantitative simulation of germinal center dynamics: biological and modeling insights from experimental validation. Journal of Theoretical Biology. 211: 253-75. PMID 11444956 DOI: 10.1006/Jtbi.2001.2344  0.507
2000 Kleinstein S, Seiden P. Simulating the immune system Computing in Science & Engineering. 2: 69-77. DOI: 10.1109/5992.852392  0.35
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