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Erol Fikrig - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Molecular Biology, Microbiology Biology, Immunology
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337 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chuang YM, Alameh MG, Abouneameh S, Raduwan H, Ledizet M, Weissman D, Fikrig E. A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria. Npj Vaccines. 8: 88. PMID 37286568 DOI: 10.1038/s41541-023-00679-x  0.319
2023 Mazuecos L, Alberdi P, Hernández-Jarguín A, Contreras M, Villar M, Cabezas-Cruz A, Simo L, González-García A, Díaz-Sánchez S, Neelakanta G, Bonnet SI, Fikrig E, de la Fuente J. Frankenbacteriosis targeting interactions between pathogen and symbiont to control infection in the tick vector. Iscience. 26: 106697. PMID 37168564 DOI: 10.1016/j.isci.2023.106697  0.319
2023 Marín-López A, Raduwan H, Chen TY, Utrilla-Trigo S, Wolfhard DP, Fikrig E. Mosquito Salivary Proteins and Arbovirus Infection: From Viral Enhancers to Potential Targets for Vaccines. Pathogens (Basel, Switzerland). 12. PMID 36986293 DOI: 10.3390/pathogens12030371  0.345
2022 Tang X, Arora G, Matias J, Hart T, Cui Y, Fikrig E. A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ. Cell Reports. 41: 111673. PMID 36417869 DOI: 10.1016/j.celrep.2022.111673  0.391
2021 Arora G, Sajid A, Chuang YM, Dong Y, Gupta A, Gambardella K, DePonte K, Almeras L, Dimopolous G, Fikrig E. Immunomodulation by Mosquito Salivary Protein AgSAP Contributes to Early Host Infection by . Mbio. e0309121. PMID 34903042 DOI: 10.1128/mBio.03091-21  0.36
2021 Chuang YM, Tang XD, Fikrig E. A mosquito AgTRIO monoclonal antibody reduces early infection of mice. Infection and Immunity. IAI0035921. PMID 34724388 DOI: 10.1128/IAI.00359-21  0.354
2021 Geng T, Yang D, Lin T, Harrison AG, Wang B, Torrance B, Wang K, Wang Y, Yang L, Haynes L, Cheng G, Vella AT, Fikrig E, Wang P. An Essential Role of UBXN3B in B Lymphopoiesis. Biorxiv : the Preprint Server For Biology. PMID 34462748 DOI: 10.1101/2021.03.04.433919  0.352
2021 Marin-Lopez A, Jiang J, Wang Y, Cao Y, MacNeil T, Hastings AK, Fikrig E. Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination. Plos Neglected Tropical Diseases. 15: e0009442. PMID 34115766 DOI: 10.1371/journal.pntd.0009442  0.347
2021 Marin-Lopez A, Wang Y, Jiang J, Ledizet M, Fikrig E. AgBR1 and NeSt1 antisera protect mice from Aedes aegypti-borne Zika infection. Vaccine. PMID 33622591 DOI: 10.1016/j.vaccine.2021.01.072  0.43
2020 Chuang YM, Agunbiade TA, Tang XD, Freudzon M, Almeras L, Fikrig E. A mosquito salivary protein facilitates sporozoite traversal of host cells. The Journal of Infectious Diseases. PMID 33306099 DOI: 10.1093/infdis/jiaa759  0.381
2020 Gupta A, Arora G, Rosen CE, Kloos Z, Cao Y, Cerny J, Sajid A, Hoornstra D, Golovchenko M, Rudenko N, Munderloh U, Hovius JW, Booth CJ, Jacobs-Wagner C, Palm NW, ... ... Fikrig E, et al. A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis. Plos Pathogens. 16: e1009030. PMID 33175909 DOI: 10.1371/journal.ppat.1009030  0.346
2020 Geng T, Lin T, Yang D, Harrison AG, Vella AT, Fikrig E, Wang P. A critical role for STING signaling in limiting pathogenesis of Chikungunya virus. The Journal of Infectious Diseases. PMID 33161431 DOI: 10.1093/infdis/jiaa694  0.347
2020 Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses. 12. PMID 33147869 DOI: 10.3390/v12111252  0.338
2020 Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, ... ... Fikrig E, et al. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology. 3: 556. PMID 33033362 DOI: 10.1038/s42003-020-01285-6  0.328
2020 Kurokawa C, Narasimhan S, Vidyarthi A, Booth CJ, Mehta S, Meister L, Diktas H, Strank N, Lynn GE, DePonte K, Craft J, Fikrig E. Repeat tick exposure elicits distinct immune responses in guinea pigs and mice. Ticks and Tick-Borne Diseases. 11: 101529. PMID 32993942 DOI: 10.1016/J.Ttbdis.2020.101529  0.395
2020 Cao Y, Rosen C, Arora G, Gupta A, Booth CJ, Murfin KE, Cerny J, Marin Lopez A, Chuang YM, Tang X, Pal U, Ring A, Narasimhan S, Fikrig E. An protein disulfide isomerase contributes to colonization of the vector. Infection and Immunity. PMID 32928964 DOI: 10.1128/Iai.00426-20  0.451
2020 Kurokawa C, Lynn GE, Pedra JHF, Pal U, Narasimhan S, Fikrig E. Interactions between Borrelia burgdorferi and ticks. Nature Reviews. Microbiology. PMID 32651470 DOI: 10.1038/S41579-020-0400-5  0.444
2020 Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses. 12. PMID 32397176 DOI: 10.3390/V12050519  0.384
2020 Wang Y, Marin-Lopez A, Jiang J, Ledizet M, Fikrig E. Vaccination with AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice. Vaccines. 8. PMID 32218189 DOI: 10.3390/Vaccines8020145  0.48
2020 Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, ... Fikrig E, et al. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. Plos Neglected Tropical Diseases. 14: e0008112. PMID 32150565 DOI: 10.1371/Journal.Pntd.0008112  0.459
2020 Narasimhan S, Kurokawa C, Diktas H, Strank NO, Černý J, Murfin K, Cao Y, Lynn G, Trentleman J, Wu MJ, DePonte K, Kantor F, Anguita J, Hovius J, Fikrig E. Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance. Ticks and Tick-Borne Diseases. 101369. PMID 31924502 DOI: 10.1016/J.Ttbdis.2019.101369  0.396
2019 Yang J, Schleicher TR, Dong Y, Park HB, Lan J, Cresswell P, Crawford J, Dimopoulos G, Fikrig E. Disruption of in impairs ovarian development and infection. The Journal of Experimental Medicine. PMID 31658986 DOI: 10.1084/Jem.20190682  0.45
2019 Gomes-Solecki M, Arnaboldi PM, Backenson PB, Benach JL, Cooper CL, Dattwyler RJ, Diuk-Wasser M, Fikrig E, Hovius JW, Laegreid W, Lundberg U, Marconi RT, Marques AR, Molloy P, Narasimhan S, et al. Protective Immunity and New Vaccines for Lyme Disease. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 31620776 DOI: 10.1093/Cid/Ciz872  0.411
2019 Koetsveld J, Platonov AE, Kuleshov K, Wagemakers A, Hoornstra D, Ang W, Szekeres S, van Duijvendijk GLA, Fikrig E, Embers ME, Sprong H, Hovius JW. Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. PMID 31404672 DOI: 10.1016/J.Cmi.2019.07.026  0.415
2019 Uraki R, Hastings AK, Brackney DE, Armstrong PM, Fikrig E. AgBR1 antibodies delay lethal -borne West Nile virus infection in mice. Npj Vaccines. 4: 23. PMID 31312526 DOI: 10.1038/s41541-019-0120-x  0.382
2019 Hwang J, Wang Y, Fikrig E. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by LXR Agonist. Antimicrobial Agents and Chemotherapy. PMID 31307983 DOI: 10.1128/Aac.01220-19  0.341
2019 Chuang YM, Freudzon M, Yang J, Dong Y, Dimopoulos G, Fikrig E. Anopheles gambiae lacking inefficiently transmit to mice. Infection and Immunity. PMID 31285253 DOI: 10.1128/Iai.00326-19  0.426
2019 Murfin KE, Kleinbard R, Aydin M, Salazar SA, Fikrig E. Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition. Ticks and Tick-Borne Diseases. PMID 31204044 DOI: 10.1016/J.Ttbdis.2019.06.002  0.399
2019 Hastings AK, Uraki R, Gaitsch H, Dhaliwal K, Stanley S, Sproch H, Williamson E, MacNeil T, Marin-Lopez A, Hwang J, Wang Y, Grover JR, Fikrig E. NeSt1 protein enhances Zika virus pathogenesis by activating neutrophils. Journal of Virology. PMID 30971475 DOI: 10.1128/Jvi.00395-19  0.509
2019 Wang D, Zhang Z, Cui S, Zhao Y, Craft S, Fikrig E, You F. ELF4 facilitates innate host defenses against by activating transcription of and . The Journal of Biological Chemistry. PMID 30898878 DOI: 10.1074/Jbc.Ra118.006321  0.449
2019 Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon-mediated antiviral immunity. Science Signaling. 12. PMID 30890658 DOI: 10.1126/Scisignal.Aau4604  0.419
2019 Hastings AK, Hastings K, Uraki R, Hwang J, Gaitsch H, Dhaliwal K, Williamson E, Fikrig E. Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia. Iscience. 13: 339-350. PMID 30884311 DOI: 10.1016/J.Isci.2019.03.003  0.428
2019 Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. Nature Microbiology. PMID 30858571 DOI: 10.1038/S41564-019-0385-X  0.484
2019 Coumou J, Wagemakers A, Narasimhan S, Schuijt TJ, Ersoz JI, Oei A, de Boer OJ, Roelofs JJTH, Fikrig E, Hovius JW. The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato. Scientific Reports. 9: 1431. PMID 30723261 DOI: 10.1038/S41598-018-37922-8  0.46
2019 Marín-Lopez A, Calvo-Pinilla E, Moreno S, Utrilla-Trigo S, Nogales A, Brun A, Fikrig E, Ortego J. Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor. Viruses. 11. PMID 30625992 DOI: 10.3390/V11010035  0.427
2018 Hwang J, Jiang A, Fikrig E. Rev-erb Agonist Inhibits Chikungunya and O'nyong'nyong Virus Replication. Open Forum Infectious Diseases. 5: ofy315. PMID 30568983 DOI: 10.1093/Ofid/Ofy315  0.37
2018 Narasimhan S, Booth CJ, DePonte K, Wu MJ, Liang X, Mohanty S, Kantor F, Fikrig E. Host-specific expression of Ixodes scapularis salivary genes. Ticks and Tick-Borne Diseases. PMID 30545615 DOI: 10.1016/J.Ttbdis.2018.12.001  0.4
2018 Hwang J, Jiang A, Fikrig E. A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses. Antiviral Research. PMID 30521835 DOI: 10.1016/J.Antiviral.2018.11.017  0.402
2018 Schutzer SE, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, et al. Direct Diagnostic Tests for Lyme Disease. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 30307486 DOI: 10.1093/Cid/Ciy614  0.416
2018 Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends in Immunology. PMID 30301592 DOI: 10.1016/J.It.2018.09.003  0.388
2018 Du H, Cui S, Li Y, Yang G, Wang P, Fikrig E, You F. MiR-221 negatively regulates innate anti-viral response. Plos One. 13: e0200385. PMID 30089112 DOI: 10.1371/Journal.Pone.0200385  0.309
2018 Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E. A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission. Nature Communications. 9: 2908. PMID 30046053 DOI: 10.1038/S41467-018-05374-3  0.408
2018 Baeza Garcia A, Siu E, Sun T, Exler V, Brito L, Hekele A, Otten G, Augustijn K, Janse CJ, Ulmer JB, Bernhagen J, Fikrig E, Geall A, Bucala R. Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection. Nature Communications. 9: 2714. PMID 30006528 DOI: 10.1038/S41467-018-05041-7  0.427
2018 Moss CE, Robson A, Fikrig E, Narasimhan S. Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization. Journal of Visualized Experiments : Jove. PMID 29912204 DOI: 10.3791/57758  0.337
2018 Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature Communications. 9: 2329. PMID 29899553 DOI: 10.1038/S41467-018-04759-8  0.436
2018 Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon. 4: e00579. PMID 29862343 DOI: 10.1016/J.Heliyon.2018.E00579  0.323
2018 Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. Journal of Immunology (Baltimore, Md. : 1950). PMID 29760192 DOI: 10.4049/Jimmunol.1701677  0.338
2018 Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, ... ... Fikrig E, et al. Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice. Cell Host & Microbe. 23: 523-535.e5. PMID 29649443 DOI: 10.1016/J.Chom.2018.03.008  0.496
2018 Beloor J, Maes N, Ullah I, Uchil P, Jackson A, Fikrig E, Lee SK, Kumar P. Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus. Cell Host & Microbe. PMID 29606496 DOI: 10.1016/J.Chom.2018.03.001  0.468
2018 Uraki R, Hastings AK, Gloria-Soria A, Powell JR, Fikrig E. Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection. Plos Neglected Tropical Diseases. 12: e0006350. PMID 29505571 DOI: 10.1371/Journal.Pntd.0006350  0.423
2018 Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS. Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species. Plos One. 13: e0191725. PMID 29420552 DOI: 10.1371/Journal.Pone.0191725  0.398
2018 Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology. 3. PMID 29305462 DOI: 10.1126/Sciimmunol.Aao1680  0.394
2018 Smith AA, Yang X, Fikrig E, Pal U. Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA. Methods in Molecular Biology (Clifton, N.J.). 1690: 105-114. PMID 29032540 DOI: 10.1007/978-1-4939-7383-5_9  0.454
2017 Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, et al. Advances in Serodiagnostic Testing for Lyme Disease Are at Hand. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 29228208 DOI: 10.1093/Cid/Cix943  0.363
2017 Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E. Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization. Nature Communications. 8: 184. PMID 28775250 DOI: 10.1038/S41467-017-00208-0  0.418
2017 Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, ... ... Fikrig E, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. PMID 28636595 DOI: 10.1038/Nature22967  0.423
2017 Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific Reports. 7: 3724. PMID 28623344 DOI: 10.1038/S41598-017-03912-5  0.42
2017 Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath T, Iwasaki A, Fikrig E. Sexual transmission of ZIKV causes fetal growth restriction in mice. The Journal of Infectious Diseases. PMID 28472297 DOI: 10.1093/Infdis/Jix204  0.342
2017 Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E. A tick antivirulence protein potentiates antibiotics against Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. PMID 28438938 DOI: 10.1128/Aac.00113-17  0.311
2017 Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Reports. 19: 558-568. PMID 28423319 DOI: 10.1016/J.Celrep.2017.03.058  0.433
2017 Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Zika virus causes testicular atrophy. Science Advances. 3: e1602899. PMID 28261663 DOI: 10.1126/Sciadv.1602899  0.462
2017 Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, ... ... Fikrig E, et al. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. 8: 14401. PMID 28195158 DOI: 10.1038/Ncomms14401  0.385
2017 Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. Plos Pathogens. 13: e1006187. PMID 28152074 DOI: 10.1371/Journal.Ppat.1006187  0.374
2017 Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E. Pathogen-mediated manipulation of arthropod microbiota to promote infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096373 DOI: 10.1073/Pnas.1613422114  0.395
2016 Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S. Zika virus infection of Hofbauer cells. American Journal of Reproductive Immunology (New York, N.Y. : 1989). PMID 27966815 DOI: 10.1111/Aji.12613  0.429
2016 Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798161 DOI: 10.4049/Jimmunol.1600902  0.415
2016 Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity to Facilitate West Nile Virus Clearance. Journal of Virology. PMID 27795421 DOI: 10.1128/Jvi.01529-16  0.367
2016 Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM. Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection. Plos Neglected Tropical Diseases. 10: e0004941. PMID 27632170 DOI: 10.1371/Journal.Pntd.0004941  0.421
2016 Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E. Zika virus productively infects primary human placenta-specific macrophages. Jci Insight. 1. PMID 27595140 DOI: 10.1172/Jci.Insight.88461  0.413
2016 Troupin A, Londono-Renteria B, Conway MJ, Cloherty E, Jameson S, Higgs S, Vanlandingham DL, Fikrig E, Colpitts TM. A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection. Biochimica Et Biophysica Acta. PMID 27241849 DOI: 10.1016/J.Bbagen.2016.05.033  0.474
2016 Hwang J, Jurado KA, Fikrig E. Genetics of War and Truce between Mosquitos and Emerging Viruses. Cell Host & Microbe. 19: 583-7. PMID 27173926 DOI: 10.1016/J.Chom.2016.04.009  0.382
2016 Wagemakers A, Koetsveld J, Narasimhan S, Wickel M, Deponte K, Bleijlevens B, Jahfari S, Sprong H, Karan LS, Sarksyan DS, van der Poll T, Bockenstedt LK, Bins AD, Platonov AE, Fikrig E, et al. Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi. Journal of Immunology (Baltimore, Md. : 1950). 196: 4185-95. PMID 27076681 DOI: 10.4049/Jimmunol.1600014  0.465
2015 Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW. Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut. Journal of Molecular Medicine (Berlin, Germany). PMID 26594018 DOI: 10.1007/S00109-015-1365-0  0.4
2015 Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.). PMID 26494172 DOI: 10.1126/Science.Aab3145  0.432
2015 Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein. Plos Pathogens. 11: e1005202. PMID 26491875 DOI: 10.1371/Journal.Ppat.1005202  0.462
2015 Narasimhan S, Fikrig E. Tick microbiome: the force within. Trends in Parasitology. 31: 315-23. PMID 25936226 DOI: 10.1016/J.Pt.2015.03.010  0.337
2015 Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E. Frostbite protection in mice expressing an antifreeze glycoprotein. Plos One. 10: e0116562. PMID 25714402 DOI: 10.1371/Journal.Pone.0116562  0.35
2015 Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, et al. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clinical and Vaccine Immunology : Cvi. 22: 6-16. PMID 25355795 DOI: 10.1128/Cvi.00508-14  0.459
2015 Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. Antibodies against CRVP379 recognize native protein in Ae. aegypti. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005202.G005  0.32
2015 Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. CRVP379 interacts with mosquito prohibitin during DENV infection. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005202.G004  0.375
2015 Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. DENV infection optimally enhances CRVP379 expression. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005202.G002  0.345
2015 Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. Silencing select virally-up-regulated genes reduces DENV infection in mosquito cells. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005202.G001  0.398
2015 Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM. Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein Plos Pathogens. 11. DOI: 10.1371/journal.ppat.1005202  0.322
2014 Conway MJ, Colpitts TM, Fikrig E. Role of the Vector in Arbovirus Transmission. Annual Review of Virology. 1: 71-88. PMID 26958715 DOI: 10.1146/Annurev-Virology-031413-085513  0.343
2014 Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Antivirulence properties of an antifreeze protein. Cell Reports. 9: 417-24. PMID 25373896 DOI: 10.1016/J.Celrep.2014.09.034  0.386
2014 Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, Fikrig E. A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. Plos Pathogens. 10: e1004278. PMID 25102051 DOI: 10.1371/Journal.Ppat.1004278  0.356
2014 Li MW, Wang J, Zhao YO, Fikrig E. Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes. The Journal of Biological Chemistry. 289: 24885-97. PMID 25035430 DOI: 10.1074/Jbc.M114.554519  0.419
2014 Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, ... Fikrig E, et al. Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerging Infectious Diseases. 20: 1183-90. PMID 24960072 DOI: 10.3201/Eid2007.131587  0.365
2014 Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA. Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cellular Microbiology. 16: 1133-45. PMID 24612118 DOI: 10.1111/Cmi.12286  0.452
2014 Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunology. 27: 39-47. PMID 24605787 DOI: 10.1089/Vim.2013.0074  0.443
2014 Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E. Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Cell Host & Microbe. 15: 58-71. PMID 24439898 DOI: 10.1016/J.Chom.2013.12.001  0.336
2014 Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E. Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. Journal of Virology. 88: 164-75. PMID 24131723 DOI: 10.1128/Jvi.02235-13  0.461
2013 You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nature Immunology. 14: 1237-46. PMID 24185615 DOI: 10.1038/Ni.2756  0.4
2013 Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, et al. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proceedings of the National Academy of Sciences of the United States of America. 110: 18262-7. PMID 24145416 DOI: 10.1073/Pnas.1313965110  0.313
2013 Hovius JW, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, et al. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet. 382: 658. PMID 23953389 DOI: 10.1016/S0140-6736(13)61644-X  0.329
2013 Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E. MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. Plos One. 8: e71388. PMID 23940747 DOI: 10.1371/Journal.Pone.0071388  0.402
2013 Qian F, Chung L, Zheng W, Bruno V, Alexander RP, Wang Z, Wang X, Kurscheid S, Zhao H, Fikrig E, Gerstein M, Snyder M, Montgomery RR. Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis. Viruses. 5: 1664-81. PMID 23881275 DOI: 10.3390/V5071664  0.394
2013 Narasimhan S, Perez O, Mootien S, DePonte K, Koski RA, Fikrig E, Ledizet M. Characterization of Ixophilin, a thrombin inhibitor from the gut of Ixodes scapularis. Plos One. 8: e68012. PMID 23874485 DOI: 10.1371/Journal.Pone.0068012  0.389
2013 Wang J, Zhang Y, Zhao YO, Li MW, Zhang L, Dragovic S, Abraham NM, Fikrig E. Anopheles gambiae circumsporozoite protein-binding protein facilitates plasmodium infection of mosquito salivary glands. The Journal of Infectious Diseases. 208: 1161-9. PMID 23801601 DOI: 10.1093/Infdis/Jit284  0.4
2013 Yang X, Hegde S, Shroder DY, Smith AA, Promnares K, Neelakanta G, Anderson JF, Fikrig E, Pal U. The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes and Infection / Institut Pasteur. 15: 729-37. PMID 23774694 DOI: 10.1016/J.Micinf.2013.06.001  0.431
2013 Wang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE. UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Cell Reports. 3: 1057-70. PMID 23545497 DOI: 10.1016/J.Celrep.2013.02.027  0.402
2013 Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi infection in the United States. The New England Journal of Medicine. 368: 291-3. PMID 23323920 DOI: 10.1056/Nejmc1215469  0.399
2013 Qian F, Bolen CR, Jing C, Wang X, Zheng W, Zhao H, Fikrig E, Bruce RD, Kleinstein SH, Montgomery RR. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clinical and Vaccine Immunology : Cvi. 20: 146-55. PMID 23220997 DOI: 10.1128/Cvi.00530-12  0.335
2013 Ullmann AJ, Dolan MC, Sackal CA, Fikrig E, Piesman J, Zeidner NS. Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis Ticks and Tick-Borne Diseases. 4: 160-163. PMID 23141105 DOI: 10.1016/J.Ttbdis.2012.08.006  0.46
2013 Kahlon A, Ojogun N, Ragland SA, Seidman D, Troese MJ, Ottens AK, Mastronunzio JE, Truchan HK, Walker NJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection Infection and Immunity. 81: 65-79. PMID 23071137 DOI: 10.1128/Iai.00932-12  0.446
2012 Colpitts TM, Conway MJ, Montgomery RR, Fikrig E. West Nile Virus: biology, transmission, and human infection. Clinical Microbiology Reviews. 25: 635-48. PMID 23034323 DOI: 10.1128/Cmr.00045-12  0.404
2012 Arjona A, Silver AC, Walker WE, Fikrig E. Immunity's fourth dimension: approaching the circadian-immune connection. Trends in Immunology. 33: 607-12. PMID 23000010 DOI: 10.1016/J.It.2012.08.007  0.3
2012 Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. Plos One. 7: e44153. PMID 22952908 DOI: 10.1371/Journal.Pone.0044153  0.341
2012 Ojogun N, Kahlon A, Ragland SA, Troese MJ, Mastronunzio JE, Walker NJ, Viebrock L, Thomas RJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. Infection and Immunity. 80: 3748-60. PMID 22907813 DOI: 10.1128/Iai.00654-12  0.459
2012 Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. Journal of Immunology (Baltimore, Md. : 1950). 189: 3150-8. PMID 22896629 DOI: 10.4049/Jimmunol.1201140  0.46
2012 Liu L, Dai J, Zhao YO, Narasimhan S, Yang Y, Zhang L, Fikrig E. Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. The Journal of Infectious Diseases. 206: 1233-41. PMID 22859824 DOI: 10.1093/Infdis/Jis484  0.37
2012 Zhao YO, Kurscheid S, Zhang Y, Liu L, Zhang L, Loeliger K, Fikrig E. Enhanced survival of Plasmodium-infected mosquitoes during starvation. Plos One. 7: e40556. PMID 22808193 DOI: 10.1371/Journal.Pone.0040556  0.377
2012 Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. Fems Immunology and Medical Microbiology. 66: 211-9. PMID 22747758 DOI: 10.1111/J.1574-695X.2012.01001.X  0.483
2012 Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV. Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. Bmc Microbiology. 12: 44. PMID 22443136 DOI: 10.1186/1471-2180-12-44  0.303
2012 da Silva Voorham JM, Rodenhuis-Zybert IA, Ayala Nuñez NV, Colpitts TM, van der Ende-Metselaar H, Fikrig E, Diamond MS, Wilschut J, Smit JM. Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2. Plos One. 7: e29957. PMID 22431958 DOI: 10.1371/Journal.Pone.0029957  0.439
2012 Mastronunzio JE, Kurscheid S, Fikrig E. Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice. Journal of Bacteriology. 194: 2238-47. PMID 22389475 DOI: 10.1128/Jb.06791-11  0.43
2012 Silver AC, Arjona A, Walker WE, Fikrig E. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity. 36: 251-61. PMID 22342842 DOI: 10.1016/J.Immuni.2011.12.017  0.33
2012 Magnarelli LA, Norris SJ, Fikrig E. Serum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits. Journal of Wildlife Diseases. 48: 12-20. PMID 22247369 DOI: 10.7589/0090-3558-48.1.12  0.354
2012 Anderson JF, Main AJ, Cheng G, Ferrandino FJ, Fikrig E. Horizontal and vertical transmission of West Nile virus genotype NY99 by Culex salinarius and genotypes NY99 and WN02 by Culex tarsalis. The American Journal of Tropical Medicine and Hygiene. 86: 134-9. PMID 22232464 DOI: 10.4269/Ajtmh.2012.11-0473  0.369
2012 Silver AC, Arjona A, Hughes ME, Nitabach MN, Fikrig E. Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain, Behavior, and Immunity. 26: 407-13. PMID 22019350 DOI: 10.1016/J.Bbi.2011.10.001  0.305
2011 Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 134: 419-33. PMID 22044090 DOI: 10.1111/J.1365-2567.2011.03501.X  0.402
2011 Liu L, Narasimhan S, Dai J, Zhang L, Cheng G, Fikrig E. Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. Embo Reports. 12: 1196-203. PMID 21921936 DOI: 10.1038/Embor.2011.177  0.443
2011 Colpitts TM, Barthel S, Wang P, Fikrig E. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. Plos One. 6: e24365. PMID 21909430 DOI: 10.1371/Journal.Pone.0024365  0.373
2011 Colpitts TM, Cox J, Vanlandingham DL, Feitosa FM, Cheng G, Kurscheid S, Wang P, Krishnan MN, Higgs S, Fikrig E. Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. Plos Pathogens. 7: e1002189. PMID 21909258 DOI: 10.1371/Journal.Ppat.1002189  0.445
2011 Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Van't Veer C, Hovius JW, Fikrig E. A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host & Microbe. 10: 136-46. PMID 21843870 DOI: 10.1016/J.Chom.2011.06.010  0.487
2011 Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection. Plos One. 6: e22786. PMID 21818390 DOI: 10.1371/Journal.Pone.0022786  0.447
2011 Arjona A, Wang P, Montgomery RR, Fikrig E. Innate immune control of West Nile virus infection. Cellular Microbiology. 13: 1648-58. PMID 21790942 DOI: 10.1111/J.1462-5822.2011.01649.X  0.466
2011 van Burgel ND, Balmus NCM, Fikrig E, van Dam AP. Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice Ticks and Tick-Borne Diseases. 2: 20-26. PMID 21771533 DOI: 10.1016/J.Ttbdis.2010.10.003  0.384
2011 Colpitts TM, Cox J, Nguyen A, Feitosa F, Krishnan MN, Fikrig E. Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector. Virology. 417: 179-87. PMID 21700306 DOI: 10.1016/J.Virol.2011.06.002  0.427
2011 Colpitts TM, Rodenhuis-Zybert I, Moesker B, Wang P, Fikrig E, Smit JM. prM-antibody renders immature West Nile virus infectious in vivo. The Journal of General Virology. 92: 2281-5. PMID 21697345 DOI: 10.1099/Vir.0.031427-0  0.442
2011 Zhang L, Zhang Y, Adusumilli S, Liu L, Narasimhan S, Dai J, Zhao YO, Fikrig E. Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. Plos Pathogens. 7: e1002079. PMID 21695244 DOI: 10.1371/Journal.Ppat.1002079  0.425
2011 Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. The Journal of Infectious Diseases. 203: 1415-24. PMID 21398396 DOI: 10.1093/Infdis/Jir048  0.391
2011 Schuijt TJ, Narasimhan S, Daffre S, DePonte K, Hovius JW, Van't Veer C, van der Poll T, Bakhtiari K, Meijers JC, Boder ET, van Dam AP, Fikrig E. Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. Plos One. 6: e15926. PMID 21246036 DOI: 10.1371/Journal.Pone.0015926  0.375
2011 Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cellular Microbiology. 13: 47-61. PMID 20716207 DOI: 10.1111/J.1462-5822.2010.01516.X  0.409
2011 Schuijt TJ, Hovius JW, van der Poll T, van Dam AP, Fikrig E. Lyme borreliosis vaccination: The facts, the challenge, the future Trends in Parasitology. 27: 40-47. PMID 20594913 DOI: 10.1016/J.Pt.2010.06.006  0.333
2011 Dunne D, Silver A, Fieber J, Zeiss C, Fikrig E. O4-S2.05 Myd-88 deficient mice show evidence of productive T pallidum infection" Sexually Transmitted Infections. 87: A87-A88. DOI: 10.1136/Sextrans-2011-050109.149  0.408
2010 Dai J, Narasimhan S, Zhang L, Liu L, Wang P, Fikrig E. Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent. Plos Pathogens. 6: e1001205. PMID 21124826 DOI: 10.1371/Journal.Ppat.1001205  0.438
2010 Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR. A paradoxical role for neutrophils in the pathogenesis of West Nile virus. The Journal of Infectious Diseases. 202: 1804-12. PMID 21050124 DOI: 10.1086/657416  0.481
2010 Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nature Immunology. 11: 912-9. PMID 20818395 DOI: 10.1038/Ni.1933  0.431
2010 Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell. 142: 714-25. PMID 20797779 DOI: 10.1016/J.Cell.2010.07.038  0.447
2010 Neelakanta G, Sultana H, Fish D, Anderson JF, Fikrig E. Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. The Journal of Clinical Investigation. 120: 3179-90. PMID 20739755 DOI: 10.1172/Jci42868  0.341
2010 Magnarelli LA, Williams SC, Fikrig E. Seasonal prevalence of serum antibodies to whole cell and recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in white-tailed deer in Connecticut. Journal of Wildlife Diseases. 46: 781-90. PMID 20688684 DOI: 10.7589/0090-3558-46.3.781  0.402
2010 Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 185: 2989-97. PMID 20660705 DOI: 10.4049/Jimmunol.1000768  0.379
2010 Dunne DW, Shaw A, Bockenstedt LK, Allore HG, Chen S, Malawista SE, Leng L, Mizue Y, Piecychna M, Zhang L, Towle V, Bucala R, Montgomery RR, Fikrig E. Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. Plos One. 5: e11343. PMID 20596538 DOI: 10.1371/Journal.Pone.0011343  0.332
2010 Pedra JH, Narasimhan S, Rendić D, DePonte K, Bell-Sakyi L, Wilson IB, Fikrig E. Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum. Cellular Microbiology. 12: 1222-34. PMID 20331643 DOI: 10.1111/J.1462-5822.2010.01464.X  0.301
2010 Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. Journal of Immunology (Baltimore, Md. : 1950). 184: 2518-27. PMID 20100933 DOI: 10.4049/Jimmunol.0901022  0.301
2010 Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi. Infection and Immunity. 78: 138-44. PMID 19822652 DOI: 10.1128/Iai.00470-09  0.374
2009 Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus Cell. 139: 1243-1254. PMID 20064371 DOI: 10.1016/J.Cell.2009.12.017  0.396
2009 Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host & Microbe. 6: 482-92. PMID 19917502 DOI: 10.1016/J.Chom.2009.10.006  0.495
2009 Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. Plos Pathogens. 5: e1000610. PMID 19816558 DOI: 10.1371/Journal.Ppat.1000610  0.356
2009 Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, Flavell R. Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. The Journal of Infectious Diseases. 200: 1331-40. PMID 19754309 DOI: 10.1086/605950  0.38
2009 Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age. Trends in Immunology. 30: 325-33. PMID 19541535 DOI: 10.1016/J.It.2009.05.004  0.362
2009 Sultana H, Foellmer HG, Neelakanta G, Oliphant T, Engle M, Ledizet M, Krishnan MN, Bonafé N, Anthony KG, Marasco WA, Kaplan P, Montgomery RR, Diamond MS, Koski RA, Fikrig E. Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody. Journal of Immunology (Baltimore, Md. : 1950). 183: 650-60. PMID 19535627 DOI: 10.4049/Jimmunol.0900093  0.437
2009 Hovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, et al. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. Plos Pathogens. 5: e1000447. PMID 19461880 DOI: 10.1371/Journal.Ppat.1000447  0.398
2009 Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 27: 3013-21. PMID 19428913 DOI: 10.1016/J.Vaccine.2009.03.034  0.341
2009 Guo X, Booth CJ, Paley MA, Wang X, DePonte K, Fikrig E, Narasimhan S, Montgomery RR. Inhibition of neutrophil function by two tick salivary proteins. Infection and Immunity. 77: 2320-9. PMID 19332533 DOI: 10.1128/Iai.01507-08  0.446
2009 Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity. 30: 242-53. PMID 19200759 DOI: 10.1016/J.Immuni.2008.11.012  0.394
2009 Anthony KG, Bai F, Krishnan MN, Fikrig E, Koski RA. Effective siRNA targeting of the 3' untranslated region of the West Nile virus genome. Antiviral Research. 82: 166-8. PMID 19135091 DOI: 10.1016/J.Antiviral.2008.12.007  0.313
2009 Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine. 27: 213-22. PMID 18996430 DOI: 10.1016/J.Vaccine.2008.10.046  0.373
2008 Thomas V, Samanta S, Fikrig E. Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function. Infection and Immunity. 76: 4905-12. PMID 18765732 DOI: 10.1128/Iai.00851-08  0.372
2008 Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJ, Oei GA, Marquart JA, de Beer R, van 't Veer C, van der Poll T, Ramamoorthi N, Fikrig E, van Dam AP. Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. The Journal of Infectious Diseases. 198: 1189-97. PMID 18752445 DOI: 10.1086/591917  0.353
2008 Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes and Infection / Institut Pasteur. 10: 1300-8. PMID 18725314 DOI: 10.1016/J.Micinf.2008.07.029  0.339
2008 Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, ... ... Fikrig E, et al. RNA interference screen for human genes associated with West Nile virus infection. Nature. 455: 242-5. PMID 18690214 DOI: 10.1038/Nature07207  0.443
2008 Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2084-91. PMID 18641347 DOI: 10.4049/Jimmunol.181.3.2084  0.42
2008 Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E. Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. Journal of Virology. 82: 8978-85. PMID 18632868 DOI: 10.1128/Jvi.00314-08  0.325
2008 Anderson JF, Main AJ, Delroux K, Fikrig E. Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). Journal of Medical Entomology. 45: 445-51. PMID 18533438 DOI: 10.1603/0022-2585(2008)45[445:Eipfha]2.0.Co;2  0.394
2008 Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Journal of Virology. 82: 7613-23. PMID 18508883 DOI: 10.1128/Jvi.00618-08  0.423
2008 Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates. Infection and Immunity. 76: 2888-94. PMID 18426890 DOI: 10.1128/Iai.00232-08  0.367
2008 Kong KF, Wang X, Anderson JF, Fikrig E, Montgomery RR. West nile virus attenuates activation of primary human macrophages. Viral Immunology. 21: 78-82. PMID 18355125 DOI: 10.1089/Vim.2007.0072  0.407
2008 Hovius JW, de Jong MA, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TB. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. Plos Pathogens. 4: e31. PMID 18282094 DOI: 10.1371/Journal.Ppat.0040031  0.378
2008 Hovius JW, Levi M, Fikrig E. Salivating for knowledge: potential pharmacological agents in tick saliva. Plos Medicine. 5: e43. PMID 18271624 DOI: 10.1371/Journal.Pmed.0050043  0.372
2008 Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. Journal of Virology. 82: 4164-8. PMID 18256150 DOI: 10.1128/Jvi.02621-07  0.374
2008 Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. The Journal of Infectious Diseases. 197: 148-55. PMID 18171298 DOI: 10.1086/523764  0.424
2008 Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. The Journal of Experimental Medicine. 205: 133-41. PMID 18166585 DOI: 10.1084/Jem.20070962  0.393
2008 Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection and Immunity. 76: 308-16. PMID 17998313 DOI: 10.1128/Iai.00599-07  0.355
2007 Ledizet M, Kar K, Foellmer HG, Bonafé N, Anthony KG, Gould LH, Bushmich SL, Fikrig E, Koski RA. Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus. The Journal of Infectious Diseases. 196: 1741-8. PMID 18190253 DOI: 10.1086/523654  0.67
2007 Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. Journal of Immunology (Baltimore, Md. : 1950). 179: 8403-9. PMID 18056386 DOI: 10.4049/Jimmunol.179.12.8403  0.443
2007 Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, Fikrig E. A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host & Microbe. 2: 7-18. PMID 18005713 DOI: 10.1016/J.Chom.2007.06.001  0.447
2007 Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. The Journal of Clinical Investigation. 117: 3059-66. PMID 17909632 DOI: 10.1172/Jci32218  0.448
2007 Hovius JWR, Ramamoorthi N, Van't Veer C, De Groot KA, Nijhof AM, Jongejan F, Van Dam AP, Fikrig E. Identification of Salp15 homologues in Ixodes ricinus ticks Vector-Borne and Zoonotic Diseases. 7: 296-303. PMID 17896872 DOI: 10.1089/Vbz.2006.0624  0.376
2007 Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal of Immunology (Baltimore, Md. : 1950). 179: 4783-91. PMID 17878377 DOI: 10.4049/Jimmunol.179.7.4783  0.346
2007 Hovius JWR, van Dam AP, Fikrig E. Tick-host-pathogen interactions in Lyme borreliosis Trends in Parasitology. 23: 434-438. PMID 17656156 DOI: 10.1016/J.Pt.2007.07.001  0.375
2007 Tyson K, Elkins C, Patterson H, Fikrig E, De Silva A. Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway Insect Molecular Biology. 16: 469-479. PMID 17651236 DOI: 10.1111/J.1365-2583.2007.00742.X  0.389
2007 Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infection and Immunity. 75: 4237-44. PMID 17620358 DOI: 10.1128/Iai.00632-07  0.419
2007 Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. Fems Immunology and Medical Microbiology. 50: 401-10. PMID 17521390 DOI: 10.1111/J.1574-695X.2007.00270.X  0.32
2007 Narasimhan S, Deponte K, Marcantonio N, Liang X, Royce TE, Nelson KF, Booth CJ, Koski B, Anderson JF, Kantor F, Fikrig E. Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission. Plos One. 2: e451. PMID 17505544 DOI: 10.1371/Journal.Pone.0000451  0.409
2007 McDonald WF, Huleatt JW, Foellmer HG, Hewitt D, Tang J, Desai P, Price A, Jacobs A, Takahashi VN, Huang Y, Nakaar V, Alexopoulou L, Fikrig E, Powell TJ. A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. The Journal of Infectious Diseases. 195: 1607-17. PMID 17471430 DOI: 10.1086/517613  0.436
2007 Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. Plos Pathogens. 3: e33. PMID 17352535 DOI: 10.1371/Journal.Ppat.0030033  0.396
2007 Thomas V, Fikrig E. Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection. Cellular Microbiology. 9: 1730-7. PMID 17346310 DOI: 10.1111/J.1462-5822.2007.00908.X  0.404
2007 Hovius JW, Li X, Ramamoorthi N, van Dam AP, Barthold SW, van der Poll T, Speelman P, Fikrig E. Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. Fems Immunology and Medical Microbiology. 49: 224-34. PMID 17328756 DOI: 10.1111/J.1574-695X.2006.00177.X  0.412
2007 Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, Fikrig E. Rab 5 is required for the cellular entry of dengue and West Nile viruses. Journal of Virology. 81: 4881-5. PMID 17301152 DOI: 10.1128/Jvi.02210-06  0.373
2007 Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Molecular Microbiology. 63: 694-710. PMID 17181780 DOI: 10.1111/J.1365-2958.2006.05550.X  0.347
2007 Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal of Virology. 81: 2047-55. PMID 17151121 DOI: 10.1128/Jvi.01840-06  0.341
2006 Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E. Antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in white-footed mice Journal of Wildlife Diseases. 42: 732-738. PMID 17255439 DOI: 10.7589/0090-3558-42.4.732  0.426
2006 Pedra JH, Narasimhan S, Deponte K, Marcantonio N, Kantor FS, Fikrig E. Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition. The American Journal of Tropical Medicine and Hygiene. 75: 677-82. PMID 17038693 DOI: 10.4269/Ajtmh.2006.75.677  0.334
2006 Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y. Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. Journal of Virology. 80: 11000-8. PMID 16943291 DOI: 10.1128/Jvi.01735-06  0.641
2006 Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 1825-32. PMID 16849493 DOI: 10.4049/Jimmunol.177.3.1825  0.441
2006 Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. The Journal of Experimental Medicine. 203: 1507-17. PMID 16717118 DOI: 10.1084/Jem.20060208  0.47
2006 Li X, Liu X, Beck DS, Kantor FS, Fikrig E. Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity Infection and Immunity. 74: 3305-3313. PMID 16714558 DOI: 10.1128/Iai.02035-05  0.434
2006 Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. Journal of Virology. 80: 5338-48. PMID 16699014 DOI: 10.1128/Jvi.00274-06  0.4
2006 Fikrig E, Narasimhan S. Borrelia burgdorferi-Traveling incognito? Microbes and Infection. 8: 1390-1399. PMID 16698304 DOI: 10.1016/J.Micinf.2005.12.022  0.347
2005 Magnarelli LA, Bushmich SL, Ijdo JW, Fikrig E. Seroprevalence of antibodies against Borrelia burgdorferi and Anaplasma phagocytophilum in cats American Journal of Veterinary Research. 66: 1895-1899. PMID 16334946 DOI: 10.2460/Ajvr.2005.66.1895  0.378
2005 Sukumaran B, Carlyon JA, Cai JL, Berliner N, Fikrig E. Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infection and Immunity. 73: 8089-99. PMID 16299303 DOI: 10.1128/Iai.73.12.8089-8099.2005  0.393
2005 Gould LH, Sui J, Foellmer H, Oliphant T, Wang T, Ledizet M, Murakami A, Noonan K, Lambeth C, Kar K, Anderson JF, de Silva AM, Diamond MS, Koski RA, Marasco WA, ... Fikrig E, et al. Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. Journal of Virology. 79: 14606-13. PMID 16282460 DOI: 10.1128/Jvi.79.23.14606-14613.2005  0.713
2005 Carlyon JA, Ryan D, Archer K, Fikrig E. Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infection and Immunity. 73: 7629-36. PMID 16239567 DOI: 10.1128/Iai.73.11.7629-7636.2005  0.439
2005 Xu O, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi Infection and Immunity. 73: 7208-7215. PMID 16239515 DOI: 10.1128/Iai.73.11.7208-7215.2005  0.333
2005 Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E. The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature. 436: 573-7. PMID 16049492 DOI: 10.1038/Nature03812  0.501
2005 Pedra JH, Sukumaran B, Carlyon JA, Berliner N, Fikrig E. Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics. 86: 365-77. PMID 16005178 DOI: 10.1016/J.Ygeno.2005.05.008  0.353
2005 Ledizet M, Kar K, Foellmer HG, Wang T, Bushmich SL, Anderson JF, Fikrig E, Koski RA. A recombinant envelope protein vaccine against West Nile virus. Vaccine. 23: 3915-24. PMID 15917113 DOI: 10.1016/J.Vaccine.2005.03.006  0.491
2005 Bai F, Wang T, Pal U, Bao F, Gould LH, Fikrig E. Use of RNA interference to prevent lethal murine west nile virus infection. The Journal of Infectious Diseases. 191: 1148-54. PMID 15747251 DOI: 10.1086/428507  0.684
2005 Thomas V, Samanta S, Wu C, Berliner N, Fikrig E. Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein Infection and Immunity. 73: 208-218. PMID 15618156 DOI: 10.1128/Iai.73.1.208-218.2005  0.364
2005 Fikrig E, Kantor FS, Barthold SW, Flavell RA. Protective immunity in lyme borreliosis. Parasitology Today (Personal Ed.). 9: 129-31. PMID 15463734 DOI: 10.1016/0169-4758(93)90176-G  0.361
2005 De Silva AM, Fikrig E. Borrelia burgdorferi genes selectively expressed in ticks and mammals. Parasitology Today (Personal Ed.). 13: 267-70. PMID 15275064 DOI: 10.1016/S0169-4758(97)01074-0  0.366
2005 Gaines P, Thomas V, Fikrig E, Berliner N. Infection with Anaplasma phagocytophilum Inhibits Proliferation and Differentiation of Myeloid Progenitors: New Insight into Infection-Related Pancytopenia. Blood. 106: 3065-3065. DOI: 10.1182/Blood.V106.11.3065.3065  0.394
2004 Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine. 10: 1366-73. PMID 15558055 DOI: 10.1038/Nm1140  0.409
2004 Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, Desilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF, Fikrig E. TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell. 119: 457-68. PMID 15537536 DOI: 10.1016/J.Cell.2004.10.027  0.38
2004 Wang T, Akkoyunlu M, Banerjee R, Fikrig E. Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice Fems Immunology and Medical Microbiology. 42: 299-305. PMID 15477043 DOI: 10.1016/J.Femsim.2004.06.001  0.35
2004 Liang FT, Yan J, Mbow ML, Sviat SL, Gilmore RD, Mamula M, Fikrig E. Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infection and Immunity. 72: 5759-67. PMID 15385475 DOI: 10.1128/Iai.72.10.5759-5767.2004  0.45
2004 Magnarelli LA, IJdo JW, Ramakrishnan U, Henderson DW, Stafford KC, Fikrig E. Use of recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in enzyme-linked immunosorbent assays to detect antibodies in white-tailed deer. Journal of Wildlife Diseases. 40: 249-58. PMID 15362824 DOI: 10.7589/0090-3558-40.2.249  0.371
2004 Scorpio DG, Akkoyunlu M, Fikrig E, Dumler JS. CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis Clinical and Diagnostic Laboratory Immunology. 11: 963-968. PMID 15358660 DOI: 10.1128/Cdli.11.5.963-968.2004  0.422
2004 Liang FT, Brown EL, Wang T, Iozzo RV, Fikrig E. Protective niche for Borrelia burgdorferi to evade humoral immunity. The American Journal of Pathology. 165: 977-85. PMID 15331421 DOI: 10.1016/S0002-9440(10)63359-7  0.49
2004 Carlyon JA, Abdel-Latif D, Pypaert M, Lacy P, Fikrig E. Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infection and Immunity. 72: 4772-83. PMID 15271939 DOI: 10.1128/Iai.72.8.4772-4783.2004  0.348
2004 Wang T, Fikrig E. Immunity to West Nile virus Current Opinion in Immunology. 16: 519-523. PMID 15245749 DOI: 10.1016/J.Coi.2004.05.008  0.449
2004 Liang FT, Caimano MJ, Radolf JD, Fikrig E. Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA. Microbial Pathogenesis. 37: 35-40. PMID 15194158 DOI: 10.1016/J.Micpath.2004.02.007  0.423
2004 Gould LH, Fikrig E. West Nile virus: a growing concern? The Journal of Clinical Investigation. 113: 1102-7. PMID 15085186 DOI: 10.1172/Jci21623  0.631
2004 Fikrig E, Coyle PK, Schutzer SE, Chen M, Deng Z, Flavell RA. Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease Journal of Clinical Microbiology. 42: 1243-1246. PMID 15004083 DOI: 10.1128/Jcm.42.3.1243-1246.2004  0.357
2004 Yang XF, Pal U, Alani SM, Fikrig E, Norgard MV. Essential role for OspA/B in the life cycle of the Lyme disease spirochete. The Journal of Experimental Medicine. 199: 641-8. PMID 14981112 DOI: 10.1084/Jem.20031960  0.351
2004 Fikrig E, Pal U, Chen M, Anderson JF, Flavell RA. OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis. Infection and Immunity. 72: 1755-9. PMID 14977984 DOI: 10.1128/Iai.72.3.1755-1759.2004  0.399
2004 Narasimhan S, Montgomery RR, DePonte K, Tschudi C, Marcantonio N, Anderson JF, Sauer JR, Cappello M, Kantor FS, Fikrig E. Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 101: 1141-6. PMID 14745044 DOI: 10.1073/Pnas.0307669100  0.374
2004 Pal U, Yang X, Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. The Journal of Clinical Investigation. 113: 220-30. PMID 14722614 DOI: 10.1172/Jci19894  0.366
2004 Wong SJ, Demarest VL, Boyle RH, Wang T, Ledizet M, Kar K, Kramer LD, Fikrig E, Koski RA. Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. Journal of Clinical Microbiology. 42: 65-72. PMID 14715733 DOI: 10.1128/Jcm.42.1.65-72.2004  0.378
2003 Narasimhan S, Caimano MJ, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E, Camaino MJ. Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proceedings of the National Academy of Sciences of the United States of America. 100: 15953-8. PMID 14671329 DOI: 10.1073/Pnas.2432412100  0.335
2003 Anguita J, Hedrick MN, Fikrig E. Adaptation of Borrelia burgdorferi in the tick and the mammalian host. Fems Microbiology Reviews. 27: 493-504. PMID 14550942 DOI: 10.1016/S0168-6445(03)00036-6  0.401
2003 Carlyon JA, Fikrig E. Invasion and survival strategies of Anaplasma phagocytophilum. Cellular Microbiology. 5: 743-54. PMID 14531890 DOI: 10.1046/J.1462-5822.2003.00323.X  0.344
2003 Wong SJ, Boyle RH, Demarest VL, Woodmansee AN, Kramer LD, Li H, Drebot M, Koski RA, Fikrig E, Martin DA, Shi PY. Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. Journal of Clinical Microbiology. 41: 4217-23. PMID 12958248 DOI: 10.1128/Jcm.41.9.4217-4223.2003  0.476
2003 Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. Journal of Immunology (Baltimore, Md. : 1950). 171: 2524-31. PMID 12928402 DOI: 10.4049/Jimmunol.171.5.2524  0.413
2003 Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood. 102: 3387-95. PMID 12869507 DOI: 10.1182/Blood-2003-02-0621  0.423
2003 Yago T, Leppänen A, Carlyon JA, Akkoyunlu M, Karmakar S, Fikrig E, Cummings RD, McEver RP. Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. The Journal of Biological Chemistry. 278: 37987-97. PMID 12847092 DOI: 10.1074/Jbc.M305778200  0.327
2003 Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes and Infection / Institut Pasteur. 5: 659-66. PMID 12787742 DOI: 10.1016/S1286-4579(03)00097-2  0.391
2003 Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 100: 1879-84. PMID 12571365 DOI: 10.1073/Pnas.0237137100  0.367
2002 Thomas V, Fikrig E. The Lyme disease vaccine takes its toll Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 2: 217-222. PMID 12804162 DOI: 10.1089/153036602321653798  0.366
2002 Wang T, Magnarelli LA, Anderson JF, Gould LH, Bushmich SL, Wong SJ, Fikrig E. A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis. Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 2: 105-9. PMID 12653304 DOI: 10.1089/153036602321131904  0.686
2002 Carlyon JA, Chan WT, Galán J, Roos D, Fikrig E. Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. Journal of Immunology (Baltimore, Md. : 1950). 169: 7009-18. PMID 12471136 DOI: 10.4049/Jimmunol.169.12.7009  0.388
2002 Anguita J, Samanta S, Ananthanarayanan SK, Revilla B, Geba GP, Barthold SW, Fikrig E. Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. Fems Immunology and Medical Microbiology. 34: 187-91. PMID 12423770 DOI: 10.1111/J.1574-695X.2002.Tb00623.X  0.353
2002 Narasimhan S, Koski RA, Beaulieu B, Anderson JF, Ramamoorthi N, Kantor F, Cappello M, Fikrig E. A novel family of anticoagulants from the saliva of Ixodes scapularis Insect Molecular Biology. 11: 641-650. PMID 12421422 DOI: 10.1046/J.1365-2583.2002.00375.X  0.308
2002 Ijdo JW, Wu C, Telford SR, Fikrig E. Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis Infection and Immunity. 70: 5295-5298. PMID 12183586 DOI: 10.1128/Iai.70.9.5295-5298.2002  0.394
2002 Magnarelli LA, Lawrenz M, Norris SJ, Fikrig E. Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. Journal of Medical Microbiology. 51: 649-55. PMID 12171295 DOI: 10.1099/0022-1317-51-8-649  0.374
2002 Wang T, Malawista SE, Pal U, Grey M, Meek J, Akkoyunlu M, Thomas V, Fikrig E. Superoxide anion production during Anaplasma phagocytophila infection. The Journal of Infectious Diseases. 186: 274-80. PMID 12134266 DOI: 10.1086/341451  0.397
2002 Anguita J, Ramamoorthi N, Hovius JWR, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Salp15, an Ixodes scapularis salivary protein, inhibits CD4+ T cell activation Immunity. 16: 849-859. PMID 12121666 DOI: 10.1016/S1074-7613(02)00325-4  0.317
2002 Liang FT, Kenneth Nelson F, Fikrig E. Molecular adaptation of Borrelia burgdorferi in the murine host Journal of Experimental Medicine. 196: 275-280. PMID 12119353 DOI: 10.1084/Jem.20020770  0.418
2002 Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine. 8: 878-84. PMID 12091878 DOI: 10.1038/Nm732  0.356
2002 Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 6352-7. PMID 12055252 DOI: 10.4049/Jimmunol.168.12.6352  0.318
2002 Magnarelli LA, Ijdo JW, Sherman BA, Bushmich SL, Levy SA, Fikrig E. Antibodies to granulocytic ehrlichiae in cattle from Connecticut Journal of Medical Microbiology. 51: 326-331. PMID 11926738 DOI: 10.1099/0022-1317-51-4-326  0.336
2002 Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Oliver JH, Fikrig E. Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. American Journal of Veterinary Research. 62: 1365-9. PMID 11560261 DOI: 10.2460/Ajvr.2001.62.1365  0.311
2001 Tsao J, Barbour AG, Luke CJ, Fikrig E, Fish D. OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks Vector Borne Zoonotic Dis. 1: 65-74. PMID 12653137 DOI: 10.1089/153036601750137705  0.36
2001 Wang T, Anderson JF, Magnarelli LA, Bushmich S, Wong S, Koski RA, Fikrig E. West Nile virus envelope protein role in diagnosis and immunity Annals of the New York Academy of Sciences. 951: 325-327. PMID 11797789 DOI: 10.1111/J.1749-6632.2001.Tb02708.X  0.451
2001 Wang T, Anderson JF, Magnarelli LA, Wong SJ, Koski RA, Fikrig E. Immunization of mice against west nile virus with recombinant envelope protein Journal of Immunology. 167: 5273-5277. PMID 11673542 DOI: 10.4049/Jimmunol.167.9.5273  0.445
2001 Das S, Banerjee G, DePonte K, Marcantonio N, Kantor FS, Fikrig E. Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands Journal of Infectious Diseases. 184: 1056-1064. PMID 11574922 DOI: 10.1086/323351  0.388
2001 Magnarelli L, IJdo J, Wu C, Fikrig E. Recombinant protein-44-based class-specific enzyme-linked immunosorbent assays for serologic diagnosis of human granulocytic ehrlichiosis European Journal of Clinical Microbiology and Infectious Diseases. 20: 482-485. PMID 11561804 DOI: 10.1007/S100960100542  0.342
2001 Anguita J, Thomas V, Samanta S, Persinski R, Hernanz C, Barthold SW, Fikrig E. Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination. Journal of Immunology (Baltimore, Md. : 1950). 167: 3383-90. PMID 11544329 DOI: 10.4049/Jimmunol.167.6.3383  0.406
2001 Akkoyunlu M, Malawista SE, Anguita J, Fikrig E. Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis. Infection and Immunity. 69: 5577-88. PMID 11500432 DOI: 10.1128/Iai.69.9.5577-5588.2001  0.385
2001 De Martino SJ, Carlyon JA, Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis. The New England Journal of Medicine. 345: 150-1. PMID 11450674 DOI: 10.1056/Nejm200107123450218  0.386
2001 Pal U, Montgomery RR, Lusitani D, Voet P, Weynants V, Malawista SE, Lobet Y, Fikrig E. Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody. Journal of Immunology (Baltimore, Md. : 1950). 166: 7398-403. PMID 11390491 DOI: 10.4049/Jimmunol.166.12.7398  0.378
2001 Thomas V, Anguita J, Samanta S, Rosa PA, Stewart P, Barthold SW, Fikrig E. Dissociation of infectivity and pathogenicity in Borrelia burgdorferi. Infection and Immunity. 69: 3507-9. PMID 11292785 DOI: 10.1128/Iai.69.5.3507-3509.2001  0.366
2001 Thomas V, Anguita J, Barthold SW, Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis. Infection and Immunity. 69: 3359-71. PMID 11292759 DOI: 10.1128/Iai.69.5.3359-3371.2001  0.47
2000 Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Padula SJ, Fikrig E. Serologic confirmation of Ehrlichia equi and Borrelia burgdorferi infections in horses from the northeastern United States. Journal of the American Veterinary Medical Association. 217: 1045-50. PMID 11019714 DOI: 10.2460/Javma.2000.217.1045  0.337
2000 Pal U, de Silva AM, Montgomery RR, Fish D, Anguita J, Anderson JF, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. The Journal of Clinical Investigation. 106: 561-9. PMID 10953031 DOI: 10.1172/Jci9427  0.418
2000 Banerjee R, Anguita J, Fikrig E. Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase. Infection and Immunity. 68: 4361-2. PMID 10858261 DOI: 10.1128/Iai.68.7.4361-4362.2000  0.358
2000 Fikrig E, Feng W, Barthold SW, Telford SR, Flavell RA. Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. Journal of Immunology (Baltimore, Md. : 1950). 164: 5344-51. PMID 10799897 DOI: 10.4049/Jimmunol.164.10.5344  0.479
2000 Banerjee R, Anguita J, Roos D, Fikrig E. Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. Journal of Immunology (Baltimore, Md. : 1950). 164: 3946-9. PMID 10754283 DOI: 10.4049/Jimmunol.164.8.3946  0.403
2000 IJdo JW, Meek JI, Cartter ML, Magnarelli LA, Wu C, Tenuta SW, Fikrig E, Ryder RW. The emergence of another tickborne infection in the 12-town area around Lyme, Connecticut: human granulocytic ehrlichiosis. The Journal of Infectious Diseases. 181: 1388-93. PMID 10751139 DOI: 10.1086/315389  0.367
2000 Akkoyunlu M, Fikrig E. Gamma interferon dominates the murine cytokine response to the agent of human granulocytic ehrlichiosis and helps to control the degree of early rickettsemia. Infection and Immunity. 68: 1827-33. PMID 10722570 DOI: 10.1128/Iai.68.4.1827-1833.2000  0.39
2000 Anguita J, Samanta S, Revilla B, Suk K, Das S, Barthold SW, Fikrig E. Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity Infection and Immunity. 68: 1222-1230. PMID 10678930 DOI: 10.1128/Iai.68.3.1222-1230.2000  0.414
2000 Magnarelli LA, Ijdo JW, Padula SJ, Flavell RA, Fikrig E. Serologic Diagnosis of Lyme Borreliosis by Using Enzyme-Linked Immunosorbent Assays with Recombinant Antigens Journal of Clinical Microbiology. 38: 1735-1739. DOI: 10.1128/Jcm.38.5.1735-1739.2000  0.35
1999 IJdo JW, Wu C, Magnarelli LA, Fikrig E. Serodiagnosis of human granulocytic ehrlichiosis by a recombinant HGE-44-based enzyme-linked immunosorbent assay. Journal of Clinical Microbiology. 37: 3540-4. PMID 10523549 DOI: 10.1128/Jcm.37.11.3540-3544.1999  0.348
1999 Magnarelli LA, Ijdo JW, Stafford KC, Fikrig E. Infections of granulocytic ehrlichiae and Borrelia burgdorferi in white-tailed deer in Connecticut. Journal of Wildlife Diseases. 35: 266-74. PMID 10231753 DOI: 10.7589/0090-3558-35.2.266  0.385
1999 Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E, Oliver JH, Hutcheson HJ, Boone JL. Antibodies to granulocytic ehrlichiae in white-footed and cotton mice in eastern United States. Journal of Wildlife Diseases. 35: 259-65. PMID 10231752 DOI: 10.7589/0090-3558-35.2.259  0.368
1999 Fikrig E, Chen M, Barthold SW, Anguita J, Feng W, Telford SR, Flavell RA. Borrelia burgdorferi erpT expression in the arthropod vector and murine host. Molecular Microbiology. 31: 281-90. PMID 9987129 DOI: 10.1046/J.1365-2958.1999.01171.X  0.45
1999 de Silva AM, Zeidner NS, Zhang Y, Dolan MC, Piesman J, Fikrig E. Influence of Outer Surface Protein A Antibody onBorrelia burgdorferi within Feeding Ticks Infection and Immunity. 67: 30-35. DOI: 10.1128/Iai.67.1.30-35.1999  0.404
1999 Akin E, McHugh GL, Flavell RA, Fikrig E, Steere AC. The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis Infection and Immunity. 67: 173-181. DOI: 10.1128/Iai.67.1.173-181.1999  0.362
1998 Fikrig E, Feng W, Aversa J, Schoen RT, Flavell RA. Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis. The Journal of Infectious Diseases. 178: 1198-201. PMID 9806060 DOI: 10.1086/515684  0.387
1998 Anguita J, Rincón M, Samanta S, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. The Journal of Infectious Diseases. 178: 1512-5. PMID 9780277 DOI: 10.1086/314448  0.357
1998 Brunet LR, Spielman A, Fikrig E, Telford SR. Heterogeneity of Lyme disease spirochaetes within individual vector ticks. Research in Microbiology. 148: 437-45. PMID 9765822 DOI: 10.1016/S0923-2508(97)83874-0  0.415
1998 Nazario S, Das S, De Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity American Journal of Tropical Medicine and Hygiene. 58: 780-785. PMID 9660463 DOI: 10.4269/Ajtmh.1998.58.780  0.458
1998 Ijdo JW, Sun W, Zhang Y, Magnarelli LA, Fikrig E. Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infection and Immunity. 66: 3264-9. PMID 9632594 DOI: 10.1128/Iai.66.7.3264-3269.1998  0.451
1998 Das S, Deponte K, Marcantonio NL, Ijdo JW, Hodzic E, Katavolos P, Barthold SW, Telford SR, Kantor FS, Fikrig E. Granulocytic ehrlichiosis in tick-immune guinea pigs Infection and Immunity. 66: 1803-1805. PMID 9529119 DOI: 10.1128/Iai.66.4.1803-1805.1998  0.41
1998 Hodzic E, Ijdo JW, Feng S, Katavolos P, Sun W, Maretzki CH, Fish D, Fikrig E, Telford SR, Barthold SW. Granulocytic ehrlichiosis in the laboratory mouse. The Journal of Infectious Diseases. 177: 737-45. PMID 9498456 DOI: 10.1086/514236  0.413
1998 de Silva AM, Fikrig E, Hodzic E, Kantor FS, Telford SR, Barthold SW. Immune evasion by tickborne and host-adapted Borrelia burgdorferi. The Journal of Infectious Diseases. 177: 395-400. PMID 9466527 DOI: 10.1086/514200  0.468
1998 Sun W, IJdo JW, Telford SR, Hodzic E, Zhang Y, Barthold SW, Fikrig E. Immunization against the agent of human granulocytic ehrlichiosis in a murine model. The Journal of Clinical Investigation. 100: 3014-8. PMID 9399947 DOI: 10.1172/Jci119855  0.462
1998 Magnarelli LA, Ijdo JW, Anderson JF, Padula SJ, Flavell RA, Fikrig E. Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut Journal of Clinical Microbiology. 36: 2823-2827. DOI: 10.1128/Jcm.36.10.2823-2827.1998  0.364
1998 Ijdo JW, Zhang Y, Anderson ML, Goldberg D, Fikrig E. Heat Shock Protein 70 of the Agent of Human Granulocytic Ehrlichiosis Binds to Borrelia burgdorferi Antibodies Clinical Diagnostic Laboratory Immunology. 5: 118-120. DOI: 10.1128/Cdli.5.1.118-120.1998  0.344
1997 Bockenstedt LK, Hodzic E, Feng S, Bourrel KW, De Silva A, Montgomery RR, Fikrig E, Radolf JD, Barthold SW. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice Infection and Immunity. 65: 4661-4667. PMID 9353047 DOI: 10.1128/Iai.65.11.4661-4667.1997  0.451
1997 Anguita J, Samanta S, Barthold SW, Fikrig E. Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice. Infection and Immunity. 65: 4334-6. PMID 9317045 DOI: 10.1128/Iai.65.10.4334-4336.1997  0.389
1997 IJdo JW, Zhang Y, Hodzic E, Magnarelli LA, Wilson ML, Telford SR, Barthold SW, Fikrig E. The early humoral response in human granulocytic ehrlichiosis. The Journal of Infectious Diseases. 176: 687-92. PMID 9291316 DOI: 10.1086/514091  0.452
1997 Anguita J, Roth R, Samanta S, Gee RJ, Barthold SW, Mamula M, Fikrig E. B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis. Infection and Immunity. 65: 3037-41. PMID 9234751 DOI: 10.1128/Iai.65.8.3037-3041.1997  0.366
1997 Barthold SW, Feng S, Bockenstedt LK, Fikrig E, Feen K. Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. S9-17. PMID 9233658 DOI: 10.1086/516166  0.47
1997 Fikrig E, Barthold SW, Sun W, Feng W, Telford SR, Flavell RA. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity. 6: 531-9. PMID 9175831 DOI: 10.1016/S1074-7613(00)80341-6  0.382
1997 Fikrig E, Barthold SW, Chen M, Tao H, Ali-Salaam P, Bockenstedt LK, Flavell RA. Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015. The Journal of Infectious Diseases. 175: 1000-3. PMID 9086169 DOI: 10.1086/513958  0.398
1997 Fikrig E, Barthold SW. Lyme disease in transgenic mice expressing the Borrelia burgdorferi flagellin epitope implicated in human neuroborreliosis. Fems Microbiology Letters. 148: 137-43. PMID 9084140 DOI: 10.1111/J.1574-6968.1997.Tb10279.X  0.432
1997 Das S, Barthold SW, Giles SS, Montgomery RR, Telford SR, Fikrig E. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host Journal of Clinical Investigation. 99: 987-995. PMID 9062357 DOI: 10.1172/Jci119264  0.439
1997 de Silva AM, Fikrig E. Arthropod- and host-specific gene expression by Borrelia burgdorferi. The Journal of Clinical Investigation. 99: 377-9. PMID 9022068 DOI: 10.1172/Jci119169  0.323
1997 Zhang YQ, Mathiesen D, Kolbert CP, Anderson J, Schoen RT, Fikrig E, Persing DH. Borrelia burgdorferi enzyme-linked immunosorbent assay for discrimination of OspA vaccination from spirochete infection. Journal of Clinical Microbiology. 35: 233-8. PMID 8968914 DOI: 10.1128/Jcm.35.1.233-238.1997  0.354
1997 Magnarelli LA, Flavell RA, Padula SJ, Anderson JF, Fikrig E. Serologic diagnosis of canine and equine borreliosis: use of recombinant antigens in enzyme-linked immunosorbent assays. Journal of Clinical Microbiology. 35: 169-173. DOI: 10.1128/Jcm.35.1.169-173.1997  0.332
1997 de Silva AM, Fish D, Burkot TR, Zhang Y, Fikrig E. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infection and Immunity. 65: 3146-3150. DOI: 10.1128/Iai.65.8.3146-3150.1997  0.494
1996 Das S, Shraga D, Cannon C, Lam TT, Feng S, Brunet LR, Telford SR, Barthold SW, Flavell RA, Fikrig E. Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue Research in Microbiology. 147: 739-751. PMID 9296108 DOI: 10.1016/S0923-2508(97)85121-2  0.311
1996 Anguita J, Persing DH, Rincon M, Barthold SW, Fikrig E. Effect of anti-interleukin 12 treatment on murine lyme borreliosis. The Journal of Clinical Investigation. 97: 1028-34. PMID 8613525 DOI: 10.1172/Jci118494  0.379
1996 Magnarelli LA, Anderson JF, Flavell RA, Fikrig E. Reactivity of white-footed mouse and raccoon sera to whole cell and recombinant antigens of Borrelia burgdorferi. Journal of Wildlife Diseases. 31: 339-44. PMID 8592354 DOI: 10.7589/0090-3558-31.3.339  0.388
1996 Magnarelli LA, Dumler JS, Anderson JF, Johnson RC, Fikrig E. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. Journal of Clinical Microbiology. 33: 3054-7. PMID 8576376 DOI: 10.1128/Jcm.33.11.3054-3057.1995  0.364
1996 Feng S, Barthold SW, Telford SR, Fikrig E. P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine Lyme disease. Infection and Immunity. 64: 363-5. PMID 8557366 DOI: 10.1128/Iai.64.1.363-365.1996  0.45
1996 de Silva AM, Telford SR, Brunet LR, Barthold SW, Fikrig E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. The Journal of Experimental Medicine. 183: 271-5. PMID 8551231 DOI: 10.1084/Jem.183.1.271  0.478
1996 Anderson JF, Flavell RA, Magnarelli LA, Barthold SW, Kantor FS, Wallich R, Persing DH, Mathiesen D, Fikrig E. Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. Journal of Clinical Microbiology. 34: 524-529. DOI: 10.1128/Jcm.34.3.524-529.1996  0.305
1996 Magnarelli LA, Fikrig E, Padula SJ, Anderson JF, Flavell RA. Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis. Journal of Clinical Microbiology. 34: 237-240. DOI: 10.1128/Jcm.34.2.237-240.1996  0.352
1995 Fikrig E, Telford SR, Wallich R, Chen M, Lobet Y, Matuschka FR, Kimsey RB, Kantor FS, Barthold SW, Spielman A, Flavell RA. Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. The Journal of Experimental Medicine. 181: 215-21. PMID 7807004 DOI: 10.1084/Jem.181.1.215  0.44
1995 Feng S, Barthold SW, Bockenstedt LK, Zaller DM, Fikrig E. Lyme disease in human DR4Dw4-transgenic mice. The Journal of Infectious Diseases. 172: 286-9. PMID 7797933 DOI: 10.1093/Infdis/172.1.286  0.411
1995 Barthold SW, Fikrig E, Bockenstedt LK, Persing DH. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infection and Immunity. 63: 2255-61. PMID 7768606 DOI: 10.1128/Iai.63.6.2255-2261.1995  0.444
1995 Suk K, Das S, Sun W, Jwang B, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi genes selectively expressed in the infected host Proceedings of the National Academy of Sciences of the United States of America. 92: 4269-4273. PMID 7753795 DOI: 10.1073/Pnas.92.10.4269  0.418
1995 Telford SR, Kantor FS, Lobet Y, Barthold SW, Spielman A, Flavell RA, Fikrig E. Efficacy of human Lyme disease vaccine formulations in a mouse model. The Journal of Infectious Diseases. 171: 1368-70. PMID 7751719 DOI: 10.1093/Infdis/171.5.1368  0.3
1995 Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. The Journal of Clinical Investigation. 96: 1706-14. PMID 7560061 DOI: 10.1172/Jci118215  0.404
1995 De Silva AM, Fikrig E. Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. The American Journal of Tropical Medicine and Hygiene. 53: 397-404. PMID 7485694 DOI: 10.4269/Ajtmh.1995.53.397  0.352
1995 Fikrig E, Tao H, Barthold SW, Flavell RA. Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infection and Immunity. 63: 1658-1662. DOI: 10.1128/Iai.63.5.1658-1662.1995  0.442
1995 Telford SR, Fikrig E. Progress Towards a Vaccine for Lyme Disease Clinical Immunotherapeutics. 4: 49-60. DOI: 10.1007/Bf03259070  0.372
1994 Nguyen TPK, Lam TT, Barthold SW, Telford SR, Flavell RA, Fikrig E. Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice Infection and Immunity. 62: 2079-2084. PMID 8168973 DOI: 10.1128/Iai.62.5.2079-2084.1994  0.444
1994 Fikrig E, Bockenstedt LK, Barthold SW, Chen M, Tao H, Ali-Salaam P, Telford SR, Flavell RA. Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. The Journal of Infectious Diseases. 169: 568-74. PMID 8158028 DOI: 10.1093/Infdis/169.3.568  0.461
1993 de Souza MS, Smith AL, Beck DS, Terwilliger GA, Fikrig E, Barthold SW. Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse. Infection and Immunity. 61: 1814-22. PMID 8478071 DOI: 10.1128/Iai.61.5.1814-1822.1993  0.409
1993 Telford SR, Fikrig E, Barthold SW, Brunet LR, Spielman A, Flavell RA. Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines. The Journal of Experimental Medicine. 178: 755-8. PMID 8340764 DOI: 10.1084/Jem.178.2.755  0.331
1993 Fikrig E, Tao H, Kantor FS, Barthold SW, Flavell RA. Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B. Proceedings of the National Academy of Sciences of the United States of America. 90: 4092-6. PMID 7683420 DOI: 10.1073/Pnas.90.9.4092  0.457
1993 Fikrig E, Berland R, Chen M, Williams S, Sigal LH, Flavell RA. Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 90: 183-7. PMID 7678336 DOI: 10.1073/Pnas.90.1.183  0.346
1993 Fikrig E, Magnarelli LA, Chen M, Anderson JF, Flavell RA. Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi. Journal of Clinical Microbiology. 31: 2451-2455. DOI: 10.1128/Jcm.31.9.2451-2455.1993  0.345
1993 Fikrig E, Barthold SW, Flavell RA. OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection. Infection and Immunity. 61: 2553-2557. DOI: 10.1128/Iai.61.6.2553-2557.1993  0.419
1992 Fikrig E, Telford SR, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proceedings of the National Academy of Sciences of the United States of America. 89: 5418-21. PMID 1608951 DOI: 10.1073/Pnas.89.12.5418  0.44
1992 Fikrig E, Huguenel ED, Berland R, Rahn DW, Hardin JA, Flavell RA. Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin. The Journal of Infectious Diseases. 165: 1127-32. PMID 1583333 DOI: 10.1093/Infdis/165.6.1127  0.312
1992 de Souza MS, Fikrig E, Smith AL, Flavell RA, Barthold SW. Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens. The Journal of Infectious Diseases. 165: 471-8. PMID 1531672 DOI: 10.1093/Infdis/165.3.471  0.358
1992 Magnarelli LA, Fikrig E, Berland R, Anderson JF, Flavell RA. Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis. Journal of Clinical Microbiology. 30: 3158-3162. DOI: 10.1128/Jcm.30.12.3158-3162.1992  0.364
1992 Fikrig E, Barthold SW, Kantor FS, Flavell RA. Long-term protection of mice from Lyme disease by vaccination with OspA. Infection and Immunity. 60: 773-777. DOI: 10.1128/Iai.60.3.773-777.1992  0.377
1992 Fikrig E, Barthold SW, Marcantonio N, Deponte K, Kantor FS, Flavell RA. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infection and Immunity. 60: 657-661. DOI: 10.1128/Iai.60.2.657-661.1992  0.468
1991 Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. The Journal of Infectious Diseases. 164: 1224-7. PMID 1955724 DOI: 10.1093/Infdis/164.6.1224  0.442
1990 Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (New York, N.Y.). 250: 553-6. PMID 2237407 DOI: 10.1126/Science.2237407  0.421
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