Pieter P. De Tombe - Publications

Affiliations: 
Physiology and Biophysics University of Illinois at Chicago, Chicago, IL, United States 
Area:
Physiology Biology, General Biophysics, Biomechanics Biophysics

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Pitoulis FG, Smith JJ, Pamias-Lopez B, de Tombe PP, Hayman D, Terracciano CM. MyoLoop: Design, development and validation of a standalone bioreactor for pathophysiological electromechanical in vitro cardiac studies. Experimental Physiology. PMID 37847495 DOI: 10.1113/EP091247  0.3
2023 Lookin O, Boulali N, Cazorla O, de Tombe P. Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes. Pflugers Archiv : European Journal of Physiology. 475: 1203-1210. PMID 37603101 DOI: 10.1007/s00424-023-02848-2  0.39
2023 Li J, Sundnes J, Hou Y, Laasmaa M, Ruud M, Unger A, Kolstad TR, Frisk M, Norseng PA, Yang L, Setterberg IE, Alves ES, Kalakoutis M, Sejersted OM, Lanner JT, ... ... de Tombe PP, et al. Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte. Circulation Research. PMID 37401464 DOI: 10.1161/CIRCRESAHA.123.322588  0.367
2023 Huang X, Torre I, Chiappi M, Yin Z, Vydyanath A, Cao S, Raschdorf O, Beeby M, Quigley B, de Tombe PP, Liu J, Morris EP, Luther PK. Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments. Journal of Muscle Research and Cell Motility. PMID 37115473 DOI: 10.1007/s10974-023-09647-3  0.308
2023 Dewan S, Witayavanitkul N, Kumar M, Mayer BJ, Betancourt L, Cazorla O, de Tombe PP. Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure. The Journal of General Physiology. 155. PMID 37102986 DOI: 10.1085/jgp.202213288  0.652
2022 Lookin O, Khokhlova A, Myachina T, Butova X, Cazorla O, de Tombe P. Contractile State Dependent Sarcomere Length Variability in Isolated Guinea-Pig Cardiomyocytes. Frontiers in Physiology. 13: 857471. PMID 35444559 DOI: 10.3389/fphys.2022.857471  0.303
2022 Warren CM, Halas M, Goldspink PH, Feng HZ, Herren AW, Wolska BM, de Tombe PP, Jin JP, Solaro RJ. Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways. Molecular and Cellular Biochemistry. PMID 35316461 DOI: 10.1007/s11010-022-04414-3  0.303
2020 Wadthaisong M, Wattanapermpool J, de Tombe PP, Bupha-Intr T. Suppression of myofilament cross-bridge kinetic in the heart of orchidectomized rats. Life Sciences. 261: 118342. PMID 32853655 DOI: 10.1016/j.lfs.2020.118342  0.327
2020 Pitoulis FG, Hasan W, Papadaki M, Clavere NG, Perbellini F, Harding SE, Kirk JA, Boateng SY, de Tombe PP, Terracciano CM. Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics. Journal of Molecular and Cellular Cardiology. PMID 32201175 DOI: 10.1016/J.Yjmcc.2020.03.007  0.391
2019 Wadthaisong M, Witayavanitkul N, Bupha-Intr T, Wattanapermpool J, de Tombe PP. Chronic high-dose testosterone treatment: impact on rat cardiac contractile biology. Physiological Reports. 7: e14192. PMID 31353833 DOI: 10.14814/phy2.14192  0.321
2019 Wadthaisong M, Witayavanitkul N, Bupha-Intr T, Wattanapermpool J, de Tombe PP. Chronic high-dose testosterone treatment: impact on rat cardiac contractile biology. Physiological Reports. 7: e14192. PMID 31353833 DOI: 10.14814/phy2.14192  0.321
2018 Dvornikov AV, de Tombe PP, Xu X. Phenotyping cardiomyopathy in adult zebrafish. Progress in Biophysics and Molecular Biology. PMID 29884423 DOI: 10.1016/j.pbiomolbio.2018.05.013  0.335
2017 Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Pflugers Archiv : European Journal of Physiology. PMID 28780592 DOI: 10.1007/S00424-017-2046-3  0.354
2017 Ait-Mou Y, Zhang M, Martin JL, Greaser ML, de Tombe PP. Impact of titin strain on the cardiac slow force response. Progress in Biophysics and Molecular Biology. PMID 28648628 DOI: 10.1016/J.Pbiomolbio.2017.06.009  0.484
2017 Phungphong S, Kijtawornrat A, de Tombe PP, Wattanapermpool J, Bupha-Intr T, Suksamrarn S. Acute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation. Journal of Biochemical and Molecular Toxicology. PMID 28590578 DOI: 10.1002/jbt.21942  0.375
2016 de Tombe PP, Kohl P. Which way to grow? Force over time may be the heart's Dao de jing. Global Cardiology Science & Practice. 2016: e201621. PMID 29043268 DOI: 10.21542/Gcsp.2016.21  0.314
2016 Dvornikov AV, Smolin N, Zhang M, Martin JL, Robia SL, de Tombe PP. Restrictive cardiomyopathy Troponin-I R145W mutation does not perturb myofilament length dependent activation in human cardiac sarcomeres. The Journal of Biological Chemistry. PMID 27557662 DOI: 10.1074/Jbc.M116.746172  0.319
2016 Ait-Mou Y, Hsu K, Farman GP, Kumar M, Greaser ML, Irving TC, de Tombe PP. Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858417 DOI: 10.1073/Pnas.1516732113  0.448
2016 Paudyal A, Dewan S, Ikie C, Whalley BJ, de Tombe PP, Boateng SY. Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure. The Journal of Physiology. PMID 26847743 DOI: 10.1113/Jp271809  0.587
2015 de Tombe PP, Ter Keurs HE. Cardiac muscle mechanics: Sarcomere length matters. Journal of Molecular and Cellular Cardiology. 91: 148-150. PMID 26678623 DOI: 10.1016/j.yjmcc.2015.12.006  0.694
2015 Kumar M, Govindan S, Zhang M, Khairallah R, Martin JL, Sadayappan S, de Tombe PP. Cardiac myosin binding protein C and Troponin-I phosphorylation independently modulate myofilament length dependent activation. The Journal of Biological Chemistry. PMID 26453301 DOI: 10.1074/Jbc.M115.686790  0.425
2014 Wilson K, Guggilam A, West TA, Zhang X, Trask AJ, Cismowski MJ, de Tombe P, Sadayappan S, Lucchesi PA. Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 307: H1605-17. PMID 25260618 DOI: 10.1152/ajpheart.00423.2014  0.381
2014 Bovo E, de Tombe PP, Zima AV. The role of dyadic organization in regulation of sarcoplasmic reticulum Ca(2+) handling during rest in rabbit ventricular myocytes. Biophysical Journal. 106: 1902-9. PMID 24806922 DOI: 10.1016/J.Bpj.2014.03.032  0.315
2014 Dvornikov AV, Dewan S, Alekhina OV, Pickett FB, de Tombe PP. Novel approaches to determine contractile function of the isolated adult zebrafish ventricular cardiac myocyte. The Journal of Physiology. 592: 1949-56. PMID 24591576 DOI: 10.1113/Jphysiol.2014.270678  0.686
2014 Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S. Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. The Journal of Biological Chemistry. 289: 8818-27. PMID 24509847 DOI: 10.1074/Jbc.M113.541128  0.383
2013 Bovo E, Dvornikov AV, Mazurek SR, de Tombe PP, Zima AV. Mechanisms of Ca²+ handling in zebrafish ventricular myocytes. PflüGers Archiv : European Journal of Physiology. 465: 1775-84. PMID 23821298 DOI: 10.1007/S00424-013-1312-2  0.369
2013 Mateja RD, Greaser ML, de Tombe PP. Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle. Biochimica Et Biophysica Acta. 1833: 804-11. PMID 22951219 DOI: 10.1016/J.Bbamcr.2012.08.011  0.738
2013 Henze M, Patrick SE, Hinken A, Scruggs SB, Goldspink P, de Tombe PP, Kobayashi M, Ping P, Kobayashi T, Solaro RJ. New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I. Biochimica Et Biophysica Acta. 1833: 823-32. PMID 22940544 DOI: 10.1016/J.Bbamcr.2012.08.012  0.341
2012 Mateja RD, de Tombe PP. Myofilament length-dependent activation develops within 5 ms in guinea-pig myocardium. Biophysical Journal. 103: L13-5. PMID 22828350 DOI: 10.1016/J.Bpj.2012.05.034  0.728
2012 de Tombe PP, ter Keurs HE. The velocity of cardiac sarcomere shortening: mechanisms and implications. Journal of Muscle Research and Cell Motility. 33: 431-7. PMID 22752243 DOI: 10.1007/s10974-012-9310-0  0.69
2012 Govindan S, Sarkey J, Ji X, Sundaresan NR, Gupta MP, de Tombe PP, Sadayappan S. Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. Journal of Muscle Research and Cell Motility. 33: 17-30. PMID 22527638 DOI: 10.1007/s10974-012-9292-y  0.348
2011 Belin RJ, Sumandea MP, Sievert GA, Harvey LA, Geenen DL, Solaro RJ, de Tombe PP. Interventricular differences in myofilament function in experimental congestive heart failure. PflüGers Archiv : European Journal of Physiology. 462: 795-809. PMID 21927813 DOI: 10.1007/S00424-011-1024-4  0.378
2011 Ait Mou Y, Toth A, Cassan C, Czuriga D, de Tombe PP, Papp Z, Lacampagne A, Cazorla O. Beneficial effects of SR33805 in failing myocardium. Cardiovascular Research. 91: 412-9. PMID 21467075 DOI: 10.1093/cvr/cvr096  0.386
2011 Farman GP, Gore D, Allen E, Schoenfelt K, Irving TC, de Tombe PP. Myosin head orientation: a structural determinant for the Frank-Starling relationship. American Journal of Physiology. Heart and Circulatory Physiology. 300: H2155-60. PMID 21460195 DOI: 10.1152/Ajpheart.01221.2010  0.352
2011 Karam CN, Warren CM, Rajan S, de Tombe PP, Wieczorek DF, Solaro RJ. Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation. Journal of Muscle Research and Cell Motility. 31: 315-22. PMID 21221740 DOI: 10.1007/S10974-010-9237-2  0.449
2010 Farman GP, Allen EJ, Schoenfelt KQ, Backx PH, de Tombe PP. The role of thin filament cooperativity in cardiac length-dependent calcium activation. Biophysical Journal. 99: 2978-86. PMID 21044595 DOI: 10.1016/J.Bpj.2010.09.003  0.674
2010 Biesiadecki BJ, Tachampa K, Yuan C, Jin JP, de Tombe PP, Solaro RJ. Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice. The Journal of Biological Chemistry. 285: 19688-98. PMID 20410305 DOI: 10.1074/Jbc.M109.086892  0.321
2010 de Tombe PP, Mateja RD, Tachampa K, Ait Mou Y, Farman GP, Irving TC. Myofilament length dependent activation. Journal of Molecular and Cellular Cardiology. 48: 851-8. PMID 20053351 DOI: 10.1016/J.Yjmcc.2009.12.017  0.734
2009 Scruggs SB, Hinken AC, Thawornkaiwong A, Robbins J, Walker LA, de Tombe PP, Geenen DL, Buttrick PM, Solaro RJ. Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. The Journal of Biological Chemistry. 284: 5097-106. PMID 19106098 DOI: 10.1074/Jbc.M807414200  0.318
2008 Marston SB, de Tombe PP. Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: Increased or decreased? Journal of Molecular and Cellular Cardiology. 45: 603-607. PMID 18691597 DOI: 10.1016/j.yjmcc.2008.07.004  0.418
2008 Ait Mou Y, le Guennec JY, Mosca E, de Tombe PP, Cazorla O. Differential contribution of cardiac sarcomeric proteins in the myofibrillar force response to stretch. PflüGers Archiv : European Journal of Physiology. 457: 25-36. PMID 18449562 DOI: 10.1007/s00424-008-0501-x  0.331
2008 Kobayashi T, Jin L, de Tombe PP. Cardiac thin filament regulation. PflüGers Archiv : European Journal of Physiology. 457: 37-46. PMID 18421471 DOI: 10.1007/s00424-008-0511-8  0.311
2008 Tachampa K, Kobayashi T, Wang H, Martin AF, Biesiadecki BJ, Solaro RJ, de Tombe PP. Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. The Journal of Biological Chemistry. 283: 15114-21. PMID 18378675 DOI: 10.1074/Jbc.M801636200  0.505
2008 Rice JJ, Wang F, Bers DM, de Tombe PP. Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophysical Journal. 95: 2368-90. PMID 18234826 DOI: 10.1529/Biophysj.107.119487  0.453
2008 Rice JJ, Tu Y, Poggesi C, De Tombe PP. Spatially-compressed cardiac myofilament models generate hysteresis that is not found in real muscle. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 366-77. PMID 18229700  0.49
2008 Solaro RJ, de Tombe PP. Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Cardiovascular Research. 77: 616-8. PMID 18192242 DOI: 10.1093/Cvr/Cvn004  0.367
2008 Farman GP, Tachampa K, Mateja R, Cazorla O, Lacampagne A, de Tombe PP. Blebbistatin: use as inhibitor of muscle contraction. PflüGers Archiv : European Journal of Physiology. 455: 995-1005. PMID 17994251 DOI: 10.1007/S00424-007-0375-3  0.736
2007 Tachampa K, Wang H, Farman GP, de Tombe PP. Cardiac troponin I threonine 144: role in myofilament length dependent activation. Circulation Research. 101: 1081-3. PMID 17975107 DOI: 10.1161/Circresaha.107.165258  0.569
2007 de Tombe PP, Stienen GJ. Impact of temperature on cross-bridge cycling kinetics in rat myocardium. The Journal of Physiology. 584: 591-600. PMID 17717017 DOI: 10.1113/jphysiol.2007.138693  0.36
2007 Belin RJ, Sumandea MP, Allen EJ, Schoenfelt K, Wang H, Solaro RJ, de Tombe PP. Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circulation Research. 101: 195-204. PMID 17556659 DOI: 10.1161/Circresaha.107.148288  0.327
2007 Lamberts RR, Hamdani N, Soekhoe TW, Boontje NM, Zaremba R, Walker LA, de Tombe PP, van der Velden J, Stienen GJ. Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. The Journal of Physiology. 582: 695-709. PMID 17478529 DOI: 10.1113/jphysiol.2007.134486  0.381
2007 Biesiadecki BJ, Kobayashi T, Walker JS, Solaro RJ, de Tombe PP. The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circulation Research. 100: 1486-93. PMID 17446435 DOI: 10.1161/01.Res.0000267744.92677.7F  0.438
2007 Daniels MC, Naya T, Rundell VL, de Tombe PP. Development of contractile dysfunction in rat heart failure: hierarchy of cellular events. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R284-92. PMID 17363676 DOI: 10.1152/ajpregu.00880.2006  0.345
2007 Farman GP, Allen EJ, Gore D, Irving TC, de Tombe PP. Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae. Biophysical Journal. 92: L73-5. PMID 17293398 DOI: 10.1529/Biophysj.107.104257  0.43
2007 Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ. p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Circulation Research. 100: 408-15. PMID 17234967 DOI: 10.1161/01.Res.0000258116.60404.Ad  0.314
2007 de Tombe PP, Belus A, Piroddi N, Scellini B, Walker JS, Martin AF, Tesi C, Poggesi C. Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R1129-36. PMID 17082350 DOI: 10.1152/ajpregu.00630.2006  0.39
2007 Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B. Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. American Journal of Physiology. Heart and Circulatory Physiology. 292: H259-69. PMID 16963613 DOI: 10.1152/Ajpheart.00766.2006  0.372
2006 Pyle WG, La Rotta G, de Tombe PP, Sumandea MP, Solaro RJ. Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ. Journal of Molecular and Cellular Cardiology. 41: 537-43. PMID 16870209 DOI: 10.1016/J.Yjmcc.2006.06.006  0.311
2006 Belin RJ, Sumandea MP, Kobayashi T, Walker LA, Rundell VL, Urboniene D, Yuzhakova M, Ruch SH, Geenen DL, Solaro RJ, de Tombe PP. Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2344-53. PMID 16815982 DOI: 10.1152/Ajpheart.00541.2006  0.413
2006 Farman GP, Walker JS, de Tombe PP, Irving TC. Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 291: H1847-55. PMID 16751283 DOI: 10.1152/Ajpheart.01237.2005  0.311
2006 Hussan JR, De Tombe PP, Rice JJ. A spatially-detailed model of actin and myosin interaction in the cardiac myofilament including strain-based rates and cooperative mechanisms Proceedings of the Fourth Iasted International Conference On Biomedical Engineering. 2006: 124-132.  0.368
2005 Vahebi S, Kobayashi T, Warren CM, de Tombe PP, Solaro RJ. Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circulation Research. 96: 740-7. PMID 15774859 DOI: 10.1161/01.Res.0000162457.56568.7D  0.314
2004 Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga G, de Tombe PP, Solaro RJ, Wieczorek DF. Physiological significance of troponin T binding domains in striated muscle tropomyosin. American Journal of Physiology. Heart and Circulatory Physiology. 287: H1484-94. PMID 15191887 DOI: 10.1152/Ajpheart.01112.2003  0.375
2004 Rice JJ, de Tombe PP. Approaches to modeling crossbridges and calcium-dependent activation in cardiac muscle. Progress in Biophysics and Molecular Biology. 85: 179-95. PMID 15142743 DOI: 10.1016/j.pbiomolbio.2004.01.011  0.418
2004 Bárány M, de Tombe PP. Rapid exchange of actin-bound nucleotide in perfused rat heart. American Journal of Physiology. Heart and Circulatory Physiology. 286: H1394-401. PMID 15020303 DOI: 10.1152/ajpheart.00866.2003  0.313
2004 Ke Y, Wang L, Pyle WG, de Tombe PP, Solaro RJ. Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circulation Research. 94: 194-200. PMID 14670848 DOI: 10.1161/01.Res.0000111522.02730.56  0.345
2003 Okafor C, Liao R, Perreault-Micale C, Li X, Ito T, Stepanek A, Doye A, de Tombe P, Gwathmey JK. Mg-ATPase and Ca+ activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts--effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine. Molecular and Cellular Biochemistry. 245: 77-89. PMID 12708747  0.446
2003 de Tombe PP. Cardiac myofilaments: mechanics and regulation. Journal of Biomechanics. 36: 721-30. PMID 12695002 DOI: 10.1016/S0021-9290(02)00450-5  0.505
2003 Konhilas JP, Irving TC, Wolska BM, Jweied EE, Martin AF, Solaro RJ, de Tombe PP. Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. The Journal of Physiology. 547: 951-61. PMID 12562915 DOI: 10.1113/Jphysiol.2002.038117  0.419
2003 Rice JJ, Stolovitzky G, Tu Y, de Tombe PP. Ising model of cardiac thin filament activation with nearest-neighbor cooperative interactions. Biophysical Journal. 84: 897-909. PMID 12547772 DOI: 10.1016/S0006-3495(03)74907-8  0.337
2002 Konhilas JP, Irving TC, de Tombe PP. Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation. PflüGers Archiv : European Journal of Physiology. 445: 305-10. PMID 12466931 DOI: 10.1007/s00424-002-0902-1  0.379
2002 Konhilas JP, Irving TC, de Tombe PP. Length-dependent activation in three striated muscle types of the rat. The Journal of Physiology. 544: 225-36. PMID 12356894 DOI: 10.1113/jphysiol.2002.024505  0.493
2002 Pyle WG, Sumandea MP, Solaro RJ, De Tombe PP. Troponin I serines 43/45 and regulation of cardiac myofilament function. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1215-24. PMID 12181153 DOI: 10.1152/Ajpheart.00128.2002  0.31
2002 Martin AF, Phillips RM, Kumar A, Crawford K, Abbas Z, Lessard JL, de Tombe P, Solaro RJ. Ca(2+) activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric gamma-actin. American Journal of Physiology. Heart and Circulatory Physiology. 283: H642-9. PMID 12124211 DOI: 10.1152/Ajpheart.00890.2001  0.4
2002 Pyle WG, Hart MC, Cooper JA, Sumandea MP, de Tombe PP, Solaro RJ. Actin capping protein: an essential element in protein kinase signaling to the myofilaments. Circulation Research. 90: 1299-306. PMID 12089068 DOI: 10.1161/01.Res.0000024389.03152.22  0.392
2002 Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. Functional consequences of caspase activation in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 6252-6. PMID 11972044 DOI: 10.1073/Pnas.092022999  0.358
2002 Dobesh DP, Konhilas JP, de Tombe PP. Cooperative activation in cardiac muscle: impact of sarcomere length. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1055-62. PMID 11834504 DOI: 10.1152/ajpheart.00667.2001  0.516
2002 Konhilas JP, Irving TC, de Tombe PP. Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing. Circulation Research. 90: 59-65. PMID 11786519 DOI: 10.1161/hh0102.102269  0.422
2001 Wolska BM, Vijayan K, Arteaga GM, Konhilas JP, Phillips RM, Kim R, Naya T, Leiden JM, Martin AF, de Tombe PP, Solaro RJ. Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions. The Journal of Physiology. 536: 863-70. PMID 11691878 DOI: 10.1111/J.1469-7793.2001.00863.X  0.417
2001 Daniëls MCG, Keller RS, De Tombe PP. Losartan prevents contractile dysfunction in rat myocardium after left ventricular myocardial infarction American Journal of Physiology - Heart and Circulatory Physiology. 281. PMID 11668077  0.314
2000 Irving TC, Konhilas J, Perry D, Fischetti R, De Tombe PP. Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardium American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 11045995  0.389
2000 Wannenburg T, Heijne GH, Geerdink JH, Van Den Dool HW, Janssen PML, De Tombe PP. Cross-bridge kinetics in rat myocardium: Effect of sarcomere length and calcium activation American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 10924078  0.414
1999 Wolska BM, Keller RS, Evans CC, Palmiter KA, Phillips RM, Muthuchamy M, Oehlenschlager J, Wieczorek DF, de Tombe PP, Solaro RJ. Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin. Circulation Research. 84: 745-51. PMID 10205142 DOI: 10.1161/01.Res.84.7.745  0.415
1998 de Tombe PP. Altered contractile function in heart failure. Cardiovascular Research. 37: 367-80. PMID 9614494 DOI: 10.1016/s0008-6363(97)00275-7  0.328
1997 Wannenburg T, Janssen PML, Fan D, De Tombe PP. The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment. American Journal of Physiology. Heart and Circulatory Physiology. 273: H2428-H2435. PMID 29586474 DOI: 10.1152/ajpheart.1997.273.5.H2428  0.441
1997 Wannenburg T, Janssen PML, Fan D, De Tombe PP. The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment American Journal of Physiology - Heart and Circulatory Physiology. 273. PMID 9374781  0.474
1997 Janssen PML, De Tombe PP. Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae American Journal of Physiology - Heart and Circulatory Physiology. 273. PMID 9374779  0.37
1997 Janssen PM, de Tombe PP. Uncontrolled sarcomere shortening increases intracellular Ca2+ transient in rat cardiac trabeculae. The American Journal of Physiology. 272: H1892-7. PMID 9139976 DOI: 10.1152/ajpheart.1997.272.4.H1892  0.446
1997 Guccione JM, Le Prell GS, De Tombe PP, Hunter WC. Measurements of active myocardial tension under a wide range of physiological loading conditions Journal of Biomechanics. 30: 189-192. PMID 9001940 DOI: 10.1016/S0021-9290(96)00122-4  0.374
1997 Janssen PML, De Tombe PP. Uncontrolled sarcomere shortening increases intracellular Ca2+ transient in rat cardiac trabeculae American Journal of Physiology. 272.  0.424
1996 De Tombe PP, Wannenburg T, Fan D, Little WC. Right ventricular contractile protein function in rats with left ventricular myocardial infarction American Journal of Physiology - Heart and Circulatory Physiology. 271. PMID 8760160  0.354
1995 De Tombe PP, Stienen GJM. Protein kinase A does not alter economy of force maintenance in skinned rat cardiac trabeculae Circulation Research. 76: 734-741. PMID 7728989  0.432
1994 De Tombe PP, Little WC. Inotropic effects of ejection are myocardial properties American Journal of Physiology - Heart and Circulatory Physiology. 266. PMID 8160824  0.385
1994 Wannenburg T, De Tombe PP, Little WC. Effect of adenosine on contractile state and oxygen consumption in isolated rat hearts American Journal of Physiology - Heart and Circulatory Physiology. 267. PMID 7943388  0.32
1992 De Tombe PP, Burkhoff D, Hunter WC. Effects of calcium and EMD-53998 on oxygen consumption in isolated canine hearts Circulation. 86: 1945-1954. PMID 1451266  0.422
1991 Burkhoff D, De Tombe PP, Hunter WC, Kass DA. Contractile strength and mechanical efficiency of left ventricle are enhanced by physiological afterload American Journal of Physiology - Heart and Circulatory Physiology. 260. PMID 1996700  0.302
1991 De Tombe PP, Ter Keurs HEDJ. Sarcomere dynamics in cat cardiac trabeculae Circulation Research. 68: 588-596. PMID 1991357  0.355
1991 Ter Keurs HEDJ, De Tombe PP, Backx PHM, Iwazumi T. Rheology of myocardium. The relation between force, velocity, sarcomere length and activation in rat cardiac muscle Biorheology. 28: 161-170. PMID 1932708  0.442
1991 De Tombe PP, Ter Keurs HEDJ. Lack of effect of isoproterenol on unloaded velocity of sarcomere shortening in rat cardiac trabeculae Circulation Research. 68: 382-391. PMID 1825034  0.454
1990 Schouten VJA, Bucx JJJ, De Tombe PP, Ter Keurs HEDJ. Sarcolemma, sarcoplasmic reticulum, and sarcomeres as limiting factors in force production in rat heart Circulation Research. 67: 913-922. PMID 2208614  0.39
1989 Backx PH, De Tombe PP, Van Deen JHK, Mulder BJM, Ter Keurs HEDJ. A model of propagating calcium-induced calcium release mediated by calcium diffusion Journal of General Physiology. 93: 963-977. PMID 2738577  0.473
1989 Mulder BJM, De Tombe PP, Ter Keurs HEDJ. Spontaneous and propagated contractions in rat cardiac trabeculae Journal of General Physiology. 93: 943-961. PMID 2738576  0.377
1988 ter Keurs HE, Bucx JJ, de Tombe PP, Backx P, Iwazumi T. The effects of sarcomere length and Ca++ on force and velocity of shortening in cardiac muscle Advances in Experimental Medicine and Biology. 226: 581-593. PMID 3407533  0.738
1988 Ter Keurs HEDJ, Backx PH, De Tombe PP, Mulder BJ. Aftercontractions and excitation-contraction coupling in rat cardiac muscle Canadian Journal of Physiology and Pharmacology. 66: 1239-1245. PMID 3219666 DOI: 10.1139/Y88-204  0.623
1987 Schouten VJ, van Deen JK, de Tombe P, Verveen AA. Force-interval relationship in heart muscle of mammals. A calcium compartment model. Biophysical Journal. 51: 13-26. PMID 3801581 DOI: 10.1016/S0006-3495(87)83307-6  0.394
1987 ter Keurs HE, Schouten VJ, Bucx JJ, Mulder BM, de Tombe PP. Excitation-contraction coupling in myocardium: implications of calcium release and Na+-Ca2+ exchange. Canadian Journal of Physiology and Pharmacology. 65: 619-26. PMID 3607607  0.649
1984 de Jong JW, Harmsen E, de Tombe PP, Keijzer E. The Ca-antagonist nifedipine reduces purine nucleoside and oxypurine release from ischemic heart Advances in Experimental Medicine and Biology. 165: 491-496. PMID 6720449  0.325
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