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Frank McCormick - Publications

Affiliations: 
Cell Biology University of California, San Francisco, San Francisco, CA 
Area:
Cell Biology, Virology Biology, Oncology
Website:
https://cancer.ucsf.edu/people/mccormick.frank
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324 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Nissley DV, Stephen AG, Yi M, McCormick F. Progress in Targeting KRAS Directly. Methods in Molecular Biology (Clifton, N.J.). 2797: 1-12. PMID 38570448 DOI: 10.1007/978-1-0716-3822-4_1  0.347
2023 Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Science Advances. 9: eadf4766. PMID 37450595 DOI: 10.1126/sciadv.adf4766  0.359
2023 Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F. The Ribosomal S6 Kinase 2 (RSK2)-SPRED2 complex regulates phosphorylation of RSK substrates and MAPK signaling. The Journal of Biological Chemistry. 104789. PMID 37149146 DOI: 10.1016/j.jbc.2023.104789  0.308
2022 Kim SH, Song JH, Kim MJ, Song MG, Ku AA, Bandyopadhyay S, McCormick F, Kim SE. Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells. Metabolites. 12. PMID 36144235 DOI: 10.3390/metabo12090831  0.304
2022 Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, ... ... McCormick F, et al. Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation. Cancer Discovery. PMID 35904492 DOI: 10.1158/2159-8290.CD-21-1631  0.325
2022 Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, ... ... McCormick F, et al. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. Molecular Cell. PMID 35613620 DOI: 10.1016/j.molcel.2022.04.034  0.367
2022 Lietman CD, Johnson ML, McCormick F, Lindsay CR. More to the RAS Story: KRAS Inhibition, Resistance Mechanisms, and Moving Beyond KRAS. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 42: 1-13. PMID 35561303 DOI: 10.1200/EDBK_351333  0.346
2022 Chao FA, Dharmaiah S, Taylor T, Messing S, Gillette W, Esposito D, Nissley DV, McCormick F, Byrd RA, Simanshu DK, Cornilescu G. Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics. Journal of the American Chemical Society. PMID 35213144 DOI: 10.1021/jacs.2c00007  0.318
2022 Lai LP, Fer N, Burgan W, Wall VE, Xu B, Soppet D, Esposito D, Nissley DV, McCormick F. Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35091470 DOI: 10.1073/pnas.2113491119  0.391
2021 McCormick F. A brief history of RAS and the RAS Initiative. Advances in Cancer Research. 153: 1-27. PMID 35101227 DOI: 10.1016/bs.acr.2021.07.003  0.309
2021 Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34380736 DOI: 10.1073/pnas.2103261118  0.342
2021 Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Current Biology : Cb. PMID 34237269 DOI: 10.1016/j.cub.2021.06.030  0.327
2021 Lai LP, Brel V, Sharma K, Frappier J, Le-Henanf N, Vivet B, Muzet N, Schell E, Morales R, Rooney E, Basse N, Yi M, Lacroix F, Holderfield M, Englaro W, ... ... McCormick F, et al. Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition. Slas Discovery : Advancing Life Sciences R & D. 24725552211008853. PMID 33896272 DOI: 10.1177/24725552211008853  0.341
2021 Mukhopadhyay S, Vander Heiden MG, McCormick F. The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. Nature Cancer. 2: 271-283. PMID 33870211 DOI: 10.1038/s43018-021-00184-x  0.319
2020 Lorenzo C, McCormick F. SPRED proteins and their roles in signal transduction, development, and malignancy. Genes & Development. 34: 1410-1421. PMID 33872193 DOI: 10.1101/gad.341222.120  0.303
2020 Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Molecular Systems Biology. 16: e9518. PMID 33073539 DOI: 10.15252/msb.20209518  0.379
2020 Van R, Cuevas-Navarro A, Castel P, McCormick F. The molecular functions of RIT1 and its contribution to human disease. The Biochemical Journal. 477: 2755-2770. PMID 32766847 DOI: 10.1042/Bcj20200442  0.425
2020 Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Reports. 32: 107909. PMID 32697994 DOI: 10.1016/J.Celrep.2020.107909  0.437
2020 Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ. Cutaneous T cell lymphoma PDX drug screening platform identifies cooperation between inhibitions of PI3Kα/δ and HDAC. The Journal of Investigative Dermatology. PMID 32603749 DOI: 10.1016/J.Jid.2020.05.110  0.345
2020 Yi M, Nissley DV, McCormick F, Stephens RM. ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications. Scientific Reports. 10: 10258. PMID 32581224 DOI: 10.1038/S41598-020-66986-8  0.442
2020 Moore AR, Rosenberg SC, McCormick F, Malek S. RAS-targeted therapies: is the undruggable drugged? Nature Reviews. Drug Discovery. PMID 32528145 DOI: 10.1038/S41573-020-0068-6  0.447
2020 Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proceedings of the National Academy of Sciences of the United States of America. PMID 32424096 DOI: 10.1073/Pnas.2000848117  0.444
2020 Ku AA, Hu HM, Zhao X, Shah KN, Kongara S, Wu D, McCormick F, Balmain A, Bandyopadhyay S. Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility. Nature Communications. 11: 2375. PMID 32398776 DOI: 10.1038/S41467-020-16078-Y  0.34
2020 Castel P, Rauen KA, McCormick F. The duality of human oncoproteins: drivers of cancer and congenital disorders. Nature Reviews. Cancer. PMID 32341551 DOI: 10.1038/S41568-020-0256-Z  0.374
2020 Goswami D, Chen, Yang Y, Gudla PR, Columbus J, Worthy K, Rigby M, Wheeler M, Mukhopadhyay S, Powell K, Burgan W, Wall V, Esposito D, Simanshu D, Lightstone FC, ... ... McCormick F, et al. Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior. Elife. 9. PMID 31958057 DOI: 10.7554/Elife.47654  0.421
2020 McCormick F. Sticking it to KRAS: Covalent Inhibitors Enter the Clinic. Cancer Cell. 37: 3-4. PMID 31951561 DOI: 10.1016/J.Ccell.2019.12.009  0.308
2020 Gross AM, Frone M, Gripp KW, Gelb BD, Schoyer L, Schill L, Stronach B, Biesecker LG, Esposito D, Hernandez ER, Legius E, Loh ML, Martin S, Morrison DK, Rauen KA, ... ... McCormick F, et al. Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies. American Journal of Medical Genetics. Part A. PMID 31913576 DOI: 10.1002/Ajmg.A.61485  0.404
2020 Mukhopadhyay S, Goswami D, Adiseshaiah PP, Burgan W, Yi M, Guerin TM, Kozlov SV, Nissley DV, McCormick F. Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers. Cancer Research. PMID 31911550 DOI: 10.1158/0008-5472.Can-19-1363  0.336
2020 Kim SE(, Galeas J, McCormick F. Abstract A39: The role of YAP in regulating glycogen metabolism in pancreatic cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A39  0.452
2020 DeHart C, Sharma K, Esposito D, Maciag A, Nissley D, McCormick F. Abstract 5133: Optimized RAS top-down proteomic assay reveals expanded proteoform landscape in malignant cells Cancer Research. 80: 5133-5133. DOI: 10.1158/1538-7445.Am2020-5133  0.472
2020 Lorenzo C, Young LC, Tannka A, Urisman A, McCormick F. Abstract 3765: c-Kit mediated phosphorylation of Spred1 regulates Neurofibromin-Spred1 interaction Immunology. 80: 3765-3765. DOI: 10.1158/1538-7445.Am2020-3765  0.438
2020 Mukhopadhyay S, Goswami D, Nissley DV, McCormick F. Abstract 238: Targeting glutaminolysis potentiates the efficacy of chemotherapy in RAS-driven pancreatic cancers Cancer Research. 80: 238-238. DOI: 10.1158/1538-7445.Am2020-238  0.449
2020 Silva JM, Canche L, McCormick F. Abstract 1087: NF1 regulates the RAS-related GTPases, RRAS and RRAS2, independent of RAS activity Cancer Research. 80: 1087-1087. DOI: 10.1158/1538-7445.Am2020-1087  0.464
2019 Sherekar M, Han SW, Ghirlando R, Messing S, Drew M, Rabara D, Waybright T, Juneja P, O'Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV, Gillette W, ... McCormick F, et al. Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer. The Journal of Biological Chemistry. PMID 31836666 DOI: 10.1074/Jbc.Ra119.010934  0.42
2019 Gripp KW, Schill L, Schoyer L, Stronach B, Bennett AM, Blaser S, Brown A, Burdine R, Burkitt-Wright E, Castel P, Darilek S, Dias A, Dyer T, Ellis M, Erickson G, ... ... McCormick F, et al. The sixth international RASopathies symposium: Precision medicine-From promise to practice. American Journal of Medical Genetics. Part A. PMID 31825160 DOI: 10.1002/Ajmg.A.61434  0.362
2019 Rabara D, Tran TH, Dharmaiah S, Stephens RM, McCormick F, Simanshu DK, Holderfield M. KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611389 DOI: 10.1073/Pnas.1908353116  0.391
2019 Wang VE, Xue JY, Frederick DT, Cao Y, Lin E, Wilson C, Urisman A, Carbone DP, Bernards R, Lito P, Settleman J, McCormick F, Flaherty KT. Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors Through Autocrine FGFR Pathway Activation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31515463 DOI: 10.1158/1078-0432.Ccr-18-2779  0.397
2019 Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F. Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder. Proceedings of the National Academy of Sciences of the United States of America. PMID 31399543 DOI: 10.1073/Pnas.1905516116  0.319
2019 Wang MT, Fer N, Galeas J, Collisson EA, Kim SE, Sharib J, McCormick F. Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Nature Communications. 10: 3055. PMID 31296870 DOI: 10.1038/S41467-019-11044-9  0.354
2019 Bai RY, Esposito D, Tam AJ, McCormick F, Riggins GJ, Wade Clapp D, Staedtke V. Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors. Gene Therapy. PMID 31127187 DOI: 10.1038/S41434-019-0080-9  0.436
2019 Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science (New York, N.Y.). 363: 1226-1230. PMID 30872527 DOI: 10.1126/Science.Aav1444  0.414
2019 Agamasu C, Ghirlando R, Taylor T, Messing S, Tran TH, Bindu L, Tonelli M, Nissley DV, McCormick F, Stephen AG. KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner. Biophysical Journal. PMID 30846362 DOI: 10.1016/J.Bpj.2019.02.004  0.331
2019 Lee CS, Lee LC, Yuan TL, Chakka S, Fellmann C, Lowe SW, Caplen NJ, McCormick F, Luo J. MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 30709910 DOI: 10.1073/Pnas.1817494116  0.48
2019 McCormick F. Progress in targeting RAS with small molecule drugs. The Biochemical Journal. 476: 365-374. PMID 30705085 DOI: 10.1042/Bcj20170441  0.411
2019 WU C, Yang C, Wang L, Gao H, Taha R, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ. Development of a Pathway-Directed Drug Screen Platform for Cutaneous T Cell Lymphoma Using Patient-Derived Xenograft Models Blood. 134: 1578-1578. DOI: 10.1182/Blood-2019-122589  0.305
2019 Sherekar M, Han S, Messing S, Drew M, Gillette W, Lorenzo C, McCormick F, Esposito D. Abstract 1768: Biochemical and structural analysis of the Neurofibromin (NF1) protein and a potential role for protein destabilization in Rasopathy diseases Cancer Research. 79: 1768-1768. DOI: 10.1158/1538-7445.Sabcs18-1768  0.38
2019 Su W, Yaeger R, Na N, Hechtman J, Paroder V, Misale S, Han S, Abdel-Wahab OI, McCormick F, Rosen N, Yao Z. Abstract LB-265: ARAF activates RAS by antagonizing its interaction with NF1 Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-265  0.488
2019 Tran T, Dharmaiah S, Yan W, Chan A, Waybright T, Gillette W, Esposito D, Stephen A, Nissley D, McCormick F, Simanshu DK. Abstract 960: Structures of oncogenic KRAS mutants in the active state and complexed with RasGAP provide new insights into targeting RAS-driven cancer Cancer Research. 79: 960-960. DOI: 10.1158/1538-7445.Am2019-960  0.457
2019 Stephen AG, Agarwal A, Garcia AE, Gnanakaran GS, Hettige J, Neale C, Travers T, Bhatia H, Bremer P, Carpenter T, Glosli J, Ingolfsson H, Karande P, Lightstone F, Oppelstrup T, ... ... McCormick F, et al. Abstract 3373: Identification of KRAS membrane bound states using an integrated computational and experimental approach Cancer Research. 79: 3373-3373. DOI: 10.1158/1538-7445.Am2019-3373  0.372
2019 Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Kuhn J, Dumont S, Mccormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC Cancer Research. 79: 2902-2902. DOI: 10.1158/1538-7445.Am2019-2902  0.372
2018 Lakshman B, Messing S, Schmid EM, Clogston JD, Gillette WK, Esposito D, Kessing B, Fletcher DA, Nissley DV, McCormick F, Stephen AG, Jean-Francois FL. Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane. The Journal of Biological Chemistry. PMID 30559287 DOI: 10.1074/Jbc.Ra118.005669  0.316
2018 Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, ... ... McCormick F, et al. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nature Medicine. PMID 30478424 DOI: 10.1038/S41591-018-0264-7  0.328
2018 Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, ... ... McCormick F, et al. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. American Journal of Medical Genetics. Part A. e40632. PMID 30302932 DOI: 10.1002/Ajmg.A.40632  0.469
2018 Ye X, Luke BT, Wei BR, Kaczmarczyk JA, Loncarek J, Dwyer JE, Johann DJ, Saul RG, Nissley DV, McCormick F, Whiteley GR, Blonder J. Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics. Oncotarget. 9: 26431-26452. PMID 29899869 DOI: 10.18632/Oncotarget.25449  0.327
2018 Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, ... ... McCormick F, et al. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 173: 321-337.e10. PMID 29625050 DOI: 10.1016/J.Cell.2018.03.035  0.454
2018 Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Strathern LA, Powell K, Smith B, Waters AM, Drubin D, Thomson T, Liao R, Greninger P, ... ... McCormick F, et al. Differential Effector Engagement by Oncogenic KRAS. Cell Reports. 22: 1889-1902. PMID 29444439 DOI: 10.1016/J.Celrep.2018.01.051  0.417
2018 McCormick F. c-Raf in KRas Mutant Cancers: A Moving Target. Cancer Cell. 33: 158-159. PMID 29438690 DOI: 10.1016/J.Ccell.2018.01.017  0.358
2018 Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La K, Dimitriadoy S, Liu DL, Kantheti HS, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, ... ... McCormick F, et al. Abstract 3302: The molecular landscape of oncogenic signaling pathways in The Cancer Genome Atlas Cancer Research. 78: 3302-3302. DOI: 10.1158/1538-7445.Am2018-3302  0.44
2018 Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. Abstract B098: GPX4 is a broadly shared gene vulnerability among residual tumors Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B098  0.345
2018 Wang M, Galeas J, McCormick F. Abstract B048: Activation of PKC inhibits oncogenic KRAS-driven malignancies Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B048  0.478
2017 Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, et al. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nature Communications. 8: 2200. PMID 29259156 DOI: 10.1038/S41467-017-02287-5  0.439
2017 Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. PMID 29088702 DOI: 10.1038/Nature24297  0.345
2017 Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Science Signaling. 10. PMID 28951536 DOI: 10.1126/Scisignal.Aao3332  0.41
2017 Simanshu DK, Nissley DV, McCormick F. RAS Proteins and Their Regulators in Human Disease. Cell. 170: 17-33. PMID 28666118 DOI: 10.1016/J.Cell.2017.06.009  0.416
2017 Stephens RM, Yi M, Kessing B, Nissley DV, McCormick F. Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes. Cancer Informatics. 16: 1176935117711944. PMID 28634423 DOI: 10.1177/1176935117711944  0.437
2017 Novotny CJ, Hamilton GL, McCormick F, Shokat K. Farnesyltransferase-mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. Acs Chemical Biology. PMID 28530791 DOI: 10.1021/Acschembio.7B00374  0.411
2017 Tetsu O, McCormick F. ETS-targeted therapy: can it substitute for MEK inhibitors? Clinical and Translational Medicine. 6: 16. PMID 28474232 DOI: 10.1186/S40169-017-0147-4  0.415
2017 McCormick F. Abstract IA14: Targeting Ras Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-Ia14  0.419
2017 Silva JM, Bagni RK, Ruggero D, McCormick F. Abstract B11: Oncogenic KRAS regulates 4E-BP1, a repressor of cap-dependent translation, independently of growth factor activity Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-B11  0.446
2017 McCormick F. Abstract IA17: New ways of targeting Ras Cancer Research. 77. DOI: 10.1158/1538-7445.Newfront17-Ia17  0.418
2017 Kim SE, Wang M, McCormick F. Abstract 435: Regulation of macropinocytosis-dependent cell survival in pancreatic cancer cells Cancer Research. 77: 435-435. DOI: 10.1158/1538-7445.Am2017-435  0.323
2017 Vo ED, Mercado GB, Alexander P, Moree B, Van Q, Stephen AG, Salafsky J, McCormick F. Abstract 4018: Identifying allosteric modulators of KRas using second harmonic generation Cancer Research. 77: 4018-4018. DOI: 10.1158/1538-7445.Am2017-4018  0.454
2017 Wang VE, Doench J, Root D, Bernards R, Settleman J, McCormick F. Abstract 3182: Cytoskeletal modulation results in increased tumor survival and drug resistance through attenuation of p53 dependent apoptosis Cancer Research. 77: 3182-3182. DOI: 10.1158/1538-7445.Am2017-3182  0.364
2017 Markegard E, Mercado EL, Silva JM, Galeas J, Trinidad MI, Urisman A, McCormick F. Abstract 1370: EGFR-mediated Spred1 phosphorylation inhibits NF1 to sustain constitutive Ras/MAPK signaling Cancer Research. 77: 1370-1370. DOI: 10.1158/1538-7445.Am2017-1370  0.466
2017 Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton J, Schreiber SL, McCormick F, Michael MT. Abstract 1006: Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition Cancer Research. 77: 1006-1006. DOI: 10.1158/1538-7445.Am2017-1006  0.317
2016 Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, ... McCormick F, et al. Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface. Oncotarget. PMID 27894102 DOI: 10.18632/Oncotarget.13566  0.403
2016 Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K. The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27313208 DOI: 10.1073/Pnas.1607298113  0.421
2016 Tetsu O, Phuchareon J, Eisele DW, McCormick F. ETS1 inactivation causes innate drug resistance to EGFR inhibitors. Molecular & Cellular Oncology. 3: e1078924. PMID 27308601 DOI: 10.1080/23723556.2015.1078924  0.314
2016 Stevenson DA, Schill L, Schoyer L, Andresen BS, Bakker A, Bayrak-Toydemir P, Burkitt-Wright E, Chatfield K, Elefteriou F, Elgersma Y, Fisher MJ, Franz D, Gelb BD, Goriely A, Gripp KW, ... ... McCormick F, et al. The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway. American Journal of Medical Genetics. Part A. PMID 27155140 DOI: 10.1002/Ajmg.A.37723  0.318
2016 McCormick F. K-Ras protein as a drug target. Journal of Molecular Medicine (Berlin, Germany). PMID 26960760 DOI: 10.1007/S00109-016-1382-7  0.423
2016 Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. Drug Resistance to EGFR Inhibitors in Lung Cancer. Chemotherapy. 61: 223-235. PMID 26910730 DOI: 10.1159/000443368  0.301
2016 Ai W, Yang YY, Afghani S, Gao H, Pincus LP, Wang LW, Rakhshandhroo T, Balassanian R, Rubenstein J, Gill R, McCormick F. Abstract A06: Development of a drug discovery platform using clinically relevant patient-derived xenograft models for cutaneous T cell lymphomas Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-A06  0.323
2016 Samson S, Zhou AY, Martins M, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan J, Levin R, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemens P, ... ... McCormick F, et al. Abstract C88: Genomics, advocacy, and emerging therapeutics to address triple-negative breast cancer (TNBC) outcome disparities. Cancer Epidemiology, Biomarkers & Prevention. 25. DOI: 10.1158/1538-7755.Disp15-C88  0.317
2016 Ye X, Whiteley G, Nissley D, McCormick F, Blonder J. Abstract 3894: A xenograft mouse model coupled with in-depth cell surface proteome analysis facilitates further elucidation of K-Ras driven tumorigenesis in lung carcinoma Cancer Research. 76: 3894-3894. DOI: 10.1158/1538-7445.Am2016-3894  0.395
2016 Yang C, Faraj R, Rakhshandaroo T, Afghani S, Pincus L, Bandyopadhyay S, McCormick F, Ai W. Abstract 388: Pathway-directed high throughput drug screen identifies PI3K inhibitors that synergistically potentiate anti-tumor activity of HDAC inhibitors in mycosis fungoides and Sézary syndrome Cancer Research. 76: 388-388. DOI: 10.1158/1538-7445.Am2016-388  0.406
2016 Phuchareon J, Eisele DW, McCormick F, Tetsu O. Abstract 293: EGFR inhibition generates drug-tolerant persister cells by blocking AKT activity and thus inactivating Ets-1 function Cancer Research. 76: 293-293. DOI: 10.1158/1538-7445.Am2016-293  0.421
2016 McCormick F, Wang M. Targeting K-Ras cancers Journal of Thoracic Oncology. 11: S9-S10. DOI: 10.1016/J.Jtho.2015.12.014  0.307
2015 Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F. K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell. 163: 1237-51. PMID 26590425 DOI: 10.1016/J.Cell.2015.10.041  0.431
2015 Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, Chertov O, Frank PH, Grose C, Jones JE, Meng Z, Perkins S, Van Q, Ghirlando R, Fivash M, ... ... McCormick F, et al. Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions. Scientific Reports. 5: 15916. PMID 26522388 DOI: 10.1038/Srep15916  0.364
2015 Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ, McCormick F. AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacological Research. 102: 132-137. PMID 26453958 DOI: 10.1016/J.Phrs.2015.09.022  0.331
2015 Tetsu O, Eisele DW, McCormick F. Resistance to EGFR-targeted therapy by Ets-1 inactivation. Cell Cycle (Georgetown, Tex.). 14: 3211-2. PMID 26313421 DOI: 10.1080/15384101.2015.1086200  0.35
2015 Phuchareon J, McCormick F, Eisele DW, Tetsu O. EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function. Proceedings of the National Academy of Sciences of the United States of America. 112: E3855-63. PMID 26150526 DOI: 10.1073/Pnas.1510733112  0.46
2015 Nan X, Tamgüney TM, Collisson EA, Lin LJ, Pitt C, Galeas J, Lewis S, Gray JW, McCormick F, Chu S. Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. Proceedings of the National Academy of Sciences of the United States of America. 112: 7996-8001. PMID 26080442 DOI: 10.1073/Pnas.1509123112  0.483
2015 Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Research. 75: 2851-62. PMID 25977330 DOI: 10.1158/0008-5472.Can-14-1623  0.428
2015 McCormick F. KRAS as a Therapeutic Target. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1797-801. PMID 25878360 DOI: 10.1158/1078-0432.Ccr-14-2662  0.383
2015 McCormick F. The potential of targeting Ras proteins in lung cancer. Expert Opinion On Therapeutic Targets. 19: 451-4. PMID 25558943 DOI: 10.1517/14728222.2014.1000304  0.46
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, ... ... McCormick F, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discovery. 5: 154-67. PMID 25501949 DOI: 10.1158/2159-8290.Cd-14-0552  0.381
2015 Phuchareon J, McCormick F, Eisele DW, Tetsu O. EGFR inhibition generates drug-tolerant persister cells by blocking AKT activity Cancer Cell & Microenvironment. 2. DOI: 10.14800/Ccm.1045  0.409
2015 Ai W, Yang C, Faraj R, Rakhshandhroo T, Afghani S, Pincus L, Bandyopadhyay S, McCormick F. Pathway-Directed High Throughput Drug Screen Identifies PI3K Inhibitors That Synergistically Potentiate Anti-Tumor Activity of HDAC Inhibitors in Mycosis Fungoides and Sezary Syndrome Blood. 126: 2755-2755. DOI: 10.1182/Blood.V126.23.2755.2755  0.401
2015 Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... McCormick F, et al. Abstract B48: Identification of novel drug interactions with MYC via a quantitative chemical-genetic interaction map Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B48  0.356
2015 Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... McCormick F, et al. Abstract B44: A systems approach combining genomics, advocacy, and emerging novel therapeutics to address triple-negative breast cancer (TNBC) outcomes disparities Cancer Epidemiology, Biomarkers & Prevention. 24. DOI: 10.1158/1538-7755.Disp14-B44  0.337
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... McCormick F, et al. Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr15  0.403
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... McCormick F, et al. Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr07  0.404
2015 Amzallag A, Yuan TL, Bagni R, Yi M, Stephens R, Ramawamy S, McCormick F, Benes CH. Abstract LB-247: Querying the RAS genomic network with siRNAs and and flow cytometry: Automatic, multidimensional phenotyping of 135 cancer cell lines by Gaussian mixture fitting and expectation maximization Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-247  0.362
2015 Yuan TL, Bagni R, Yi M, Amzallag A, Afghani S, Beam K, Burgan W, Fer N, Garvey L, Smith B, Waters A, Stephens R, Benes C, McCormick F. Abstract 4690: Next-generation screen for integrative subtyping and target discovery for KRAS-mutant cancer Cancer Research. 75: 4690-4690. DOI: 10.1158/1538-7445.Am2015-4690  0.407
2014 Phuchareon J, Overdevest JB, McCormick F, Eisele DW, van Zante A, Tetsu O. Fatty Acid binding protein 7 is a molecular marker in adenoid cystic carcinoma of the salivary glands: implications for clinical significance. Translational Oncology. 7: 780-7. PMID 25500088 DOI: 10.1016/J.Tranon.2014.10.003  0.335
2014 Phuchareon J, van Zante A, Overdevest JB, McCormick F, Eisele DW, Tetsu O. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands. Translational Oncology. 7: 537-45. PMID 25389449 DOI: 10.1016/J.Tranon.2014.07.006  0.332
2014 Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Reports. 8: 1037-48. PMID 25127139 DOI: 10.1016/J.Celrep.2014.07.010  0.702
2014 Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discovery. 4: 1182-97. PMID 25100204 DOI: 10.1158/2159-8290.Cd-13-0900  0.312
2014 Holderfield M, Deuker MM, McCormick F, McMahon M. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nature Reviews. Cancer. 14: 455-67. PMID 24957944 DOI: 10.1038/Nrc3760  0.412
2014 Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metabolism. 19: 694-701. PMID 24703700 DOI: 10.1016/J.Cmet.2014.03.009  0.747
2014 Stephen AG, Esposito D, Bagni RK, McCormick F. Dragging ras back in the ring. Cancer Cell. 25: 272-81. PMID 24651010 DOI: 10.1016/J.Ccr.2014.02.017  0.445
2014 Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Boussemart L, Lacroix L, Tomasic G, Favre M, Vagner S, Robert C, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D. Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors. Cancer Research. 74: 2238-45. PMID 24523442 DOI: 10.1158/0008-5472.Can-13-1065-T  0.372
2014 Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, ... ... McCormick F, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. Plos One. 9: e87220. PMID 24504419 DOI: 10.1371/Journal.Pone.0087220  0.39
2014 Salt MB, Bandyopadhyay S, McCormick F. Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation. Cancer Discovery. 4: 186-99. PMID 24302555 DOI: 10.1158/2159-8290.Cd-13-0520  0.69
2014 Nehil M, Paquette J, Tokuyasu T, McCormick F. High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A. Oncogene. 33: 5151-62. PMID 24213571 DOI: 10.1038/Onc.2013.459  0.774
2014 Sos ML, Levin R, Gordan J, Oses-Prieto J, Webber J, Salt M, Hann B, Burlingame A, Mccormick F, Bandyopadhyay S, Shokat K. Abstract LB-216: Integrated analysis of differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-216  0.708
2014 Wang VE, McCormick F, Settleman J. Abstract 3698: Hyperactive AKT pathway and reactivation of the MAPK/ERK pathway in melanoma cells resistant to dual BRAF and MEK inhibition Cancer Research. 74: 3698-3698. DOI: 10.1158/1538-7445.Am2014-3698  0.397
2014 Sos M, Levin R, Gordan J, Oses-Prieto J, Webber J, Salt M, Hann B, Burlingame A, McCormick F, Bandyopadhyay S, Shokat K. 73 Differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer European Journal of Cancer. 50: 28-29. DOI: 10.1016/S0959-8049(14)70199-6  0.681
2013 Yuan TL, McCormick F. Killing tumors by keeping ras and PI3' kinase apart. Cancer Cell. 24: 562-3. PMID 24229705 DOI: 10.1016/J.Ccr.2013.10.015  0.482
2013 Nan X, Collisson EA, Lewis S, Huang J, Tamgüney TM, Liphardt JT, McCormick F, Gray JW, Chu S. Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 18519-24. PMID 24158481 DOI: 10.1073/Pnas.1318188110  0.452
2013 Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 24: 450-65. PMID 24094812 DOI: 10.1016/J.Ccr.2013.08.020  0.335
2013 Lyons J, Bastian BC, McCormick F. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 13845-50. PMID 23908401 DOI: 10.1073/Pnas.1201917110  0.576
2013 Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, Tellew J, Hardy S, Hekmat-Nejad M, Stuart DD, McCormick F, Nagel TE. RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation. Cancer Cell. 23: 594-602. PMID 23680146 DOI: 10.1016/J.Ccr.2013.03.033  0.407
2013 Young A, Lou D, McCormick F. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discovery. 3: 112-23. PMID 23103856 DOI: 10.1158/2159-8290.Cd-12-0231  0.474
2013 Yuan TL, Lee C, Fellmann C, Ritchie C, Lee C, Merrifield C, Schluep T, Lowe SW, Luo J, McCormick F. Abstract LB-94: Nanoparticle-based RNAi therapy for the delivery of personalized siRNA payloads to KRAS-driven tumors. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-94  0.389
2013 Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D. Abstract LB-61: Vemurafenib promotes RAS wild-type tumor formation in a mouse model of HPV-driven cutaneous squamous cell carcinoma. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-61  0.398
2013 Pitt CL, McCormick F. Abstract LB-55: Comparing effects of individual Ras isoforms on cell signaling and growth. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-55  0.454
2013 Holderfield M, Merritt H, Lin J, Gao Z, Stuart D, McCormick F. Abstract LB-54: Identification of a RAF inhibitory auto-phosphorylation site. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-54  0.427
2013 Salt MB, McCormick F. Abstract LB-275: Epithelial-mesenchymal transition rewires mechanisms upstream of PI3K-dependent growth. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-275  0.434
2013 Wang M, Galeas J, Ritchie C, McCormick F. Abstract 2327: OncogenicK-RasandH-Rasdifferentially regulate cancer stem cell-like properties via repression of non-canonical Wnt signaling. Cancer Research. 73: 2327-2327. DOI: 10.1158/1538-7445.Am2013-2327  0.335
2013 McCormick F. Abstract CN01-01: Opportunities for systemic treatment using siRNA in nanoparticles. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Cn01-01  0.331
2012 Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F. A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes & Development. 26: 1421-6. PMID 22751498 DOI: 10.1101/Gad.190876.112  0.45
2012 Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, ... McCormick F, et al. Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. Plos One. 7: e37431. PMID 22662154 DOI: 10.1371/Journal.Pone.0037431  0.439
2012 Gysin SC, Pitt C, McCormick F. Abstract A32: Interfering with Ras prenylation. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A32  0.394
2012 Stowe IB, Stowe T, McCormick F, Mercado E. Abstract LB-151: Spred1 and neurofibromin interact to negatively regulate Ras/Raf/MEK/ERK signaling Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-151  0.486
2011 Gysin S, Salt M, Young A, McCormick F. Therapeutic strategies for targeting ras proteins. Genes & Cancer. 2: 359-72. PMID 21779505 DOI: 10.1177/1947601911412376  0.73
2011 Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 157: 136-46. PMID 21495172 DOI: 10.1002/Ajmg.C.30294  0.441
2011 McCormick F. Cancer therapy based on oncogene addiction. Journal of Surgical Oncology. 103: 464-7. PMID 21480237 DOI: 10.1002/jso.21749  0.322
2011 McCormick F. Mutant onco-proteins as drug targets: successes, failures, and future prospects. Current Opinion in Genetics & Development. 21: 29-33. PMID 21236660 DOI: 10.1016/J.Gde.2010.12.002  0.327
2011 Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Hardy S, Hekmat-Nejad M, McCormick F, Nagel T. Abstract LB-28: RAF inhibitors activate MAPK pathway through relief of RAF auto-inhibition Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-28  0.403
2011 Holderfield M, Lorenzana E, Chan J, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D. Abstract B129: RAF inhibition promotes tumorigenesis in a mouse model of HPV-driven squamous cell carcinoma. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B129  0.391
2010 Lee SH, McCormick F, Saya H. Mad2 inhibits the mitotic kinesin MKlp2. The Journal of Cell Biology. 191: 1069-77. PMID 21149564 DOI: 10.1083/Jcb.201003095  0.318
2010 Ishida S, McCormick F, Smith-McCune K, Hanahan D. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell. 17: 574-83. PMID 20541702 DOI: 10.1016/J.Ccr.2010.04.011  0.31
2010 Harris TJ, McCormick F. The molecular pathology of cancer. Nature Reviews. Clinical Oncology. 7: 251-65. PMID 20351699 DOI: 10.1038/Nrclinonc.2010.41  0.357
2010 Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Molecular and Cellular Biology. 30: 2264-79. PMID 20160012 DOI: 10.1128/Mcb.01450-08  0.69
2010 McCormick F. How blocking Raf activates the MAPK pathway. Pigment Cell & Melanoma Research. 23: 187-9. PMID 20128874 DOI: 10.1111/J.1755-148X.2010.00680.X  0.366
2010 Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, et al. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. American Journal of Medical Genetics. Part A. 152: 4-24. PMID 20014119 DOI: 10.1002/Ajmg.A.33183  0.346
2010 Holderfield M, McCormick F, Nagel T. Abstract 5752: Molecular mechanisms driving oncogenesis in KRAS mutant non-small cell lung cancer Cancer Research. 70: 5752-5752. DOI: 10.1158/1538-7445.Am10-5752  0.456
2010 Ikeda Y, Oda K, Murayama-Hosokawa S, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Uehara Y, Hiraike O, Kawana K, Yano T, McCormick F, Kozuma S, Taketani Y, Aburatani H. Abstract 3139: Chromosomal copy number alterations involved in Ras/PI3-kinase pathway in endometrial carcinomas Cancer Research. 70: 3139-3139. DOI: 10.1158/1538-7445.Am10-3139  0.463
2010 Oda K, Murayama-Hosokawa S, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Hiraike-Wada O, Kawana K, Yano T, McCormick F, Kozuma S, Taketani Y, Aburatani H. Abstract 2152: Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil prevalent alterations in Ras/PI3-kinase pathway Cellular and Molecular Biology. 70: 2152-2152. DOI: 10.1158/1538-7445.Am10-2152  0.345
2009 Young A, Lyons J, Miller AL, Phan VT, Alarcón IR, McCormick F. Ras signaling and therapies. Advances in Cancer Research. 102: 1-17. PMID 19595305 DOI: 10.1016/S0065-230X(09)02001-6  0.777
2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. EGFR signals to mTOR through PKC and independently of Akt in glioma. Science Signaling. 2: ra4. PMID 19176518 DOI: 10.1126/Scisignal.2000014  0.378
2009 Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, ... ... McCormick F, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Research. 69: 565-72. PMID 19147570 DOI: 10.1158/0008-5472.Can-08-3389  0.411
2009 McCormick F. Abstract PL05-03: Future challenges of targeted therapy Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-Pl05-03  0.468
2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. Erratum: EGFR signals to mTOR through PKC and independently of Akt in glioma (Science Signaling (2009) 2:60 (er4)) Science Signaling. 2. DOI: 10.1126/Scisignal.260Er4  0.301
2008 Sang HL, Sterling H, Burlingame A, McCormick F. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint Genes and Development. 22: 2926-2931. PMID 18981471 DOI: 10.1101/Gad.1677208  0.356
2008 Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Research. 68: 8127-36. PMID 18829572 DOI: 10.1158/0008-5472.Can-08-0755  0.451
2008 Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene. 27: 5303-14. PMID 18521084 DOI: 10.1038/Onc.2008.164  0.394
2008 Kitagawa M, Lee SH, McCormick F. Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Molecular Cell. 29: 217-31. PMID 18243116 DOI: 10.1016/J.Molcel.2007.11.036  0.304
2008 Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Human Molecular Genetics. 17: 419-30. PMID 17981815 DOI: 10.1093/Hmg/Ddm319  0.392
2007 McCormick F. Success and failure on the ras pathway Cancer Biology and Therapy. 6: 1654-1659. PMID 18245956 DOI: 10.4161/Cbt.6.10.5153  0.37
2007 Estep AL, Palmer C, McCormick F, Rauen KA. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. Plos One. 2: e1279. PMID 18060073 DOI: 10.1371/Journal.Pone.0001279  0.337
2007 Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. Journal of the National Cancer Institute. 99: 1410-4. PMID 17848677 DOI: 10.1093/Jnci/Djm102  0.319
2006 Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. Plos One. 1: e128. PMID 17205132 DOI: 10.1371/Journal.Pone.0000128  0.327
2006 Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, ... ... McCormick F, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 10: 515-27. PMID 17157791 DOI: 10.1016/J.Ccr.2006.10.008  0.317
2006 Lee SH, McCormick F. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins Embo Journal. 25: 4008-4019. PMID 16932749 DOI: 10.1038/Sj.Emboj.7601268  0.338
2006 Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F. Cancer targets in the Ras pathway. Cold Spring Harbor Symposia On Quantitative Biology. 70: 461-7. PMID 16869784 DOI: 10.1101/Sqb.2005.70.044  0.473
2006 Jiang H, McCormick F, Lang FF, Gomez-Manzano C, Fueyo J. Oncolytic adenoviruses as antiglioma agents. Expert Review of Anticancer Therapy. 6: 697-708. PMID 16759161 DOI: 10.1586/14737140.6.5.697  0.355
2006 Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Molecular Cell. 22: 217-30. PMID 16630891 DOI: 10.1016/J.Molcel.2006.03.027  0.477
2006 Rodriguez-Viciana P, McCormick F. Ras ubiquitination: Coupling spatial sorting and signal transmission Cancer Cell. 9: 243-244. PMID 16616329 DOI: 10.1016/J.Ccr.2006.03.025  0.397
2006 You L, Kim J, He B, Xu Z, McCormick F, Jablons DM. Wnt-1 signal as a potential cancer therapeutic target. Drug News & Perspectives. 19: 27-31. PMID 16550254 DOI: 10.1358/Dnp.2005.19.1.965871  0.395
2006 Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome Science. 311: 1287-1290. PMID 16439621 DOI: 10.1126/Science.1124642  0.35
2006 Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo J. Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 556-62. PMID 16428500 DOI: 10.1158/1078-0432.Ccr-05-1892  0.327
2006 Oda K, Stokoe D, Taketani Y, McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Research. 65: 10669-73. PMID 16322209 DOI: 10.1158/0008-5472.Can-05-2620  0.37
2005 Rodriguez-Viciana P, McCormick F. Characterization of Interactions Between Ras Family GTPases and Their Effectors Methods in Enzymology. 407: 187-194. PMID 16757324 DOI: 10.1016/S0076-6879(05)07016-3  0.395
2005 Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 8: 111-8. PMID 16098464 DOI: 10.1016/J.Ccr.2005.07.005  0.449
2005 O'Shea CC, Soria C, Bagus B, McCormick F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell. 8: 61-74. PMID 16023599 DOI: 10.1016/J.Ccr.2005.06.009  0.315
2005 Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene. 24: 5396-400. PMID 16007226 DOI: 10.1038/Sj.Onc.1208568  0.36
2005 O'Shea CC, Choi S, McCormick F, Stokoe D. Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle (Georgetown, Tex.). 4: 883-8. PMID 15970698 DOI: 10.4161/Cc.4.7.1791  0.418
2005 Klein S, McCormick F, Levitzki A. Killing time for cancer cells. Nature Reviews. Cancer. 5: 573-80. PMID 15965492 DOI: 10.1038/Nrc1651  0.38
2005 O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, McCormick F, Stokoe D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. The Embo Journal. 24: 1211-21. PMID 15775987 DOI: 10.1038/Sj.Emboj.7600597  0.405
2005 Rodriguez-Viciana P, McCormick F. RalGDS comes of age Cancer Cell. 7: 205-206. PMID 15766656 DOI: 10.1016/J.Ccr.2005.02.012  0.478
2005 He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene. 24: 3054-8. PMID 15735684 DOI: 10.1038/Sj.Onc.1208511  0.387
2005 Brandts CH, Bilanges B, Hare G, McCormick F, Stokoe D. Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells Journal of Biological Chemistry. 280: 2012-2019. PMID 15542603 DOI: 10.1074/Jbc.M408348200  0.381
2005 Mysinger C, Soria C, Yeh J, O'Shea C, Timmerman L, McCormick F. Determining the factors affecting breast cancer infectivity by oncolytic adenovirus Breast Cancer Research. 7. DOI: 10.1186/Bcr1192  0.34
2005 McCormick F, Macrae M, Tetsu O, Rodriguez-Viciana P, Phan V. CANCER THERAPY BASED ON THE Ras PATHWAY Cold Spring Harbor Symposia On Quantitative Biology. 70: 1-1. DOI: 10.1101/Sqb.2004.70.47  0.689
2004 O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 6: 611-23. PMID 15607965 DOI: 10.1016/J.Ccr.2004.11.012  0.313
2004 Moule MG, Collins CH, McCormick F, Fried M. Role for PP2A in ARF signaling to p53. Proceedings of the National Academy of Sciences of the United States of America. 101: 14063-6. PMID 15383668 DOI: 10.1073/Pnas.0405533101  0.382
2004 Reguart N, He B, Xu Z, You L, Lee AY, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F, Jablons DM. Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochemical and Biophysical Research Communications. 323: 229-34. PMID 15351726 DOI: 10.1016/J.Bbrc.2004.08.075  0.356
2004 You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F, Jablons DM. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Research. 64: 5385-9. PMID 15289346 DOI: 10.1158/0008-5472.Can-04-1227  0.345
2004 Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F, Jablons DM. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Research. 64: 4717-20. PMID 15256437 DOI: 10.1158/0008-5472.Can-04-1389  0.369
2004 Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, Jablons DM. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene. 23: 6672-6. PMID 15221014 DOI: 10.1038/Sj.Onc.1207881  0.381
2004 You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, Jablons DM. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene. 23: 6170-4. PMID 15208662 DOI: 10.1038/Sj.Onc.1207844  0.359
2004 You L, He B, Uematsu K, Xu Z, Mazieres J, Lee A, McCormick F, Jablons DM. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. Cancer Research. 64: 3474-8. PMID 15150100 DOI: 10.1158/0008-5472.Can-04-0115  0.34
2004 Rodriguez-Viciana P, Sabatier C, McCormick F. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Molecular and Cellular Biology. 24: 4943-54. PMID 15143186 DOI: 10.1128/Mcb.24.11.4943-4954.2004  0.373
2004 He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, McCormick F, Jablons DM. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia (New York, N.Y.). 6: 7-14. PMID 15068666 DOI: 10.1016/S1476-5586(04)80048-4  0.389
2004 McCormick F. Survival pathways meet their end Nature. 428: 267-269. PMID 15029179 DOI: 10.1038/428267A  0.324
2004 You L, He B, Xu Z, McCormick F, Jablons DM. Future directions: oncolytic viruses. Clinical Lung Cancer. 5: 226-30. PMID 14967074 DOI: 10.3816/Clc.2004.N.003  0.357
2004 Timmerman LA, Grego-Bessa J, Raya A, Bertrán E, Pérez-Pomares JM, Díez J, Aranda S, Palomo S, McCormick F, Izpisúa-Belmonte JC, de la Pompa JL. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development. 18: 99-115. PMID 14701881 DOI: 10.1101/Gad.276304  0.342
2003 He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 100: 14133-8. PMID 14617776 DOI: 10.1073/Pnas.2232790100  0.401
2003 Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene. 22: 7218-21. PMID 14562050 DOI: 10.1038/Sj.Onc.1206817  0.38
2003 McCormick F. Cancer-specific viruses and the development of ONYX-015 Cancer Biology &Amp; Therapy. 2. PMID 14508094 DOI: 10.4161/Cbt.216  0.355
2003 Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition Cancer Cell. 3: 233-245. PMID 12676582 DOI: 10.1016/S1535-6108(03)00053-9  0.389
2003 He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F, Jablons DM. Cloning and characterization of a functional promoter of the human SOCS-3 gene. Biochemical and Biophysical Research Communications. 301: 386-91. PMID 12565872 DOI: 10.1016/S0006-291X(02)03071-1  0.389
2003 Gump J, Stokoe D, McCormick F. Phosphorylation of p16INK4A correlates with Cdk4 association. The Journal of Biological Chemistry. 278: 6619-22. PMID 12529334 DOI: 10.1074/Jbc.C200622200  0.359
2003 McCormick F, Shannon KM. Oncogenes and cell proliferation - Insights from inherited predispositions and mouse models: Editorial overview Current Opinion in Genetics and Development. 13: 3-5. DOI: 10.1016/S0959-437X(03)00003-0  0.317
2002 Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell. 2: 103-12. PMID 12204530 DOI: 10.1016/S1535-6108(02)00102-2  0.408
2002 Johnson L, Shen A, Boyle L, Kunich J, Pandey K, Lemmon M, Hermiston T, Giedlin M, McCormick F, Fattaey A. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell. 1: 325-37. PMID 12086848 DOI: 10.1016/S1535-6108(02)00060-0  0.371
2001 McCormick F. Cancer gene therapy: Fringe or cutting edge? Nature Reviews Cancer. 1: 130-141. PMID 11905804 DOI: 10.1038/35101008  0.311
2001 Biederer C, Ries S, Brandts CH, McCormick F. Replication-selective viruses for cancer therapy. Journal of Molecular Medicine (Berlin, Germany). 80: 163-75. PMID 11894142 DOI: 10.1007/S00109-001-0295-1  0.328
2001 Wakita K, McCormick F, Tetsu O. Method for screening ecdysone-inducible stable cell lines Biotechniques. 31: 414-418. PMID 11515378 DOI: 10.2144/01312Rr03  0.322
2001 Xie J, Aszterbaum M, Zhang X, Bonifas JM, Zachary C, Epstein E, McCormick F. A role of PDGFRalpha in basal cell carcinoma proliferation. Proceedings of the National Academy of Sciences of the United States of America. 98: 9255-9. PMID 11481486 DOI: 10.1073/Pnas.151173398  0.448
2001 Yount GL, Afshar G, Ries S, Korn M, Shalev N, Basila D, McCormick F, Haas-Kogan DA. Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells. Oncogene. 20: 2826-35. PMID 11420694 DOI: 10.1038/Sj.Onc.1204393  0.352
2001 Anders M, Ding R, Lipner E, Balmain A, McCormick F, Korn W. Regulation of the coxsackie and adenovirus receptor (CAR) by the Ras/MAPK signal transduction pathway European Journal of Cancer. 37: S97. DOI: 10.1016/S0959-8049(01)80465-2  0.399
2001 Anders M, Ding RX, Balmain A, McCormick F, Korn WM. Inhibition of the Ras/MAPK pathway upregulates the human coxsackie and adenovirus receptor (CAR) and increases the uptake of adenoviruses in cancer cells Gastroenterology. 120: A11. DOI: 10.1016/S0016-5085(08)80053-4  0.443
2000 McCormick F. ONYX-015 selectivity and the p14ARF pathway Oncogene. 19: 6670-6672. PMID 11426653 DOI: 10.1038/Sj.Onc.1204096  0.378
2000 McCormick F. Interactions between adenovirus proteins and the p53 pathway: The development of ONYX-015 Seminars in Cancer Biology. 10: 453-459. PMID 11170867 DOI: 10.1006/Scbi.2000.0336  0.371
2000 McCormick F. Small-molecule inhibitors of cell signaling Current Opinion in Biotechnology. 11: 593-597. PMID 11102795 DOI: 10.1016/S0958-1669(00)00149-X  0.354
2000 Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell. 103: 321-30. PMID 11057904 DOI: 10.1016/S0092-8674(00)00123-9  0.446
2000 Ries SJ, Brandts CH, Chung AS, Biederer CH, Hann BC, Lipner EM, McCormick F, Michael Korn W. Loss of p14(ARF) in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015) Nature Medicine. 6: 1128-1133. PMID 11017144 DOI: 10.1038/80466  0.335
2000 Ding VW, Chen RH, McCormick F. Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling Journal of Biological Chemistry. 275: 32475-32481. PMID 10913153 DOI: 10.1074/Jbc.M005342200  0.326
2000 Biederer CH, Ries SJ, Moser M, Florio M, Israel MA, McCormick F, Buettner R. The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development. The Journal of Biological Chemistry. 275: 26245-51. PMID 10835421 DOI: 10.1074/Jbc.M001430200  0.337
2000 Yang CT, You L, Yeh CC, Chang JW, Zhang F, McCormick F, Jablons DM. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. Journal of the National Cancer Institute. 92: 636-41. PMID 10772681 DOI: 10.1093/Jnci/92.8.636  0.313
2000 Chen RH, Ding WV, McCormick F. Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C. The Journal of Biological Chemistry. 275: 17894-9. PMID 10749878 DOI: 10.1074/Jbc.M905336199  0.321
2000 Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Molecular Cell. 5: 13-25. PMID 10678165 DOI: 10.1016/S1097-2765(00)80399-8  0.348
2000 Haas-Kogan D, Afshar G, Ries S, Korn M, Shalev N, Berger M, McCormick F, Yount G. Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells International Journal of Radiation Oncology*Biology*Physics. 48: 248. DOI: 10.1016/S0360-3016(00)80292-8  0.3
1999 Tetsu O, McCormick F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature. 398: 422-426. PMID 10201372 DOI: 10.1038/18884  0.354
1999 Lam CW, Xie J, To KF, Ng HK, Lee KC, Yuen NW, Lim PL, Chan LY, Tong SF, McCormick F. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene. 18: 833-6. PMID 9989836 DOI: 10.1038/Sj.Onc.1202360  0.329
1999 McCormick F. Signalling networks that cause cancer Trends in Genetics. 15. DOI: 10.1016/S0968-0004(99)01480-2  0.382
1998 McCormick F. Going for the GAP Current Biology : Cb. 8. PMID 9768349 DOI: 10.1016/S0960-9822(98)70431-2  0.462
1998 Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene. 17: 313-25. PMID 9690513 DOI: 10.1038/Sj.Onc.1201947  0.355
1998 McCormick F. Why Ras needs Rho Nature. 394: 220-221. PMID 9685153 DOI: 10.1038/28268  0.427
1998 Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (New York, N.Y.). 279: 710-4. PMID 9445477 DOI: 10.1126/Science.279.5351.710  0.367
1997 Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science (New York, N.Y.). 277: 567-70. PMID 9228007 DOI: 10.1126/Science.277.5325.567  0.348
1997 Heise C, Sampson-Johannes A, Williams A, Mccormick F, Hoff DDV, Kirn DH. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Medicine. 3: 639-645. PMID 9176490 DOI: 10.1038/Nm0697-639  0.362
1997 Stokoe D, McCormick F. Activation of c-Raf-1 by Ras and Src through different mechanisms: Activation in vivo and in vitro Embo Journal. 16: 2384-2396. PMID 9171352 DOI: 10.1093/Emboj/16.9.2384  0.413
1997 Qiu RG, Abo A, McCormick F, Symons M. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Molecular and Cellular Biology. 17: 3449-58. PMID 9154844 DOI: 10.1128/Mcb.17.6.3449  0.403
1997 Cook SJ, Beltman J, Cadwallader KA, McMahon M, McCormick F. Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells. The Journal of Biological Chemistry. 272: 13309-19. PMID 9148952 DOI: 10.1074/Jbc.272.20.13309  0.396
1997 Cadwallader K, Beltman J, McCormick F, Cook S. Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells. The Biochemical Journal. 795-804. PMID 9032468 DOI: 10.1042/Bj3210795  0.387
1997 Katz ME, McCormick F. Signal transduction from multiple Ras effectors Current Opinion in Genetics and Development. 7: 75-79. PMID 9024640 DOI: 10.1016/S0959-437X(97)80112-8  0.455
1997 Bollag G, Adler F, elMasry N, McCabe PC, Conner E, Thompson P, McCormick F, Shannon K. Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. The Journal of Biological Chemistry. 271: 32491-4. PMID 8955068 DOI: 10.1074/Jbc.271.51.32491  0.461
1997 Kirn D, Heise C, Sampson-Johannes A, Williams A, Muna M, Trown P, McCormick F. ONYX-015: An adenovirus attenuated in the E1B-55KD gene selectively replicates in, and causes lysis of, P53- tumor cells European Journal of Cancer. 33: S53. DOI: 10.1016/S0959-8049(97)89466-X  0.318
1996 Kirn DH, McCormick F. Replicating viruses as selective cancer therapeutics Molecular Medicine Today. 2: 519-527. PMID 9015793 DOI: 10.1016/S1357-4310(97)81456-6  0.313
1996 Cook SJ, McCormick F. Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. The Biochemical Journal. 320: 237-45. PMID 8947493 DOI: 10.1042/Bj3200237  0.371
1996 Beltman J, McCormick F, Cook SJ. The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. The Journal of Biological Chemistry. 271: 27018-24. PMID 8900190 DOI: 10.1074/Jbc.271.43.27018  0.341
1996 Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A, McCormick F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (New York, N.Y.). 274: 373-6. PMID 8832876 DOI: 10.1126/Science.274.5286.373  0.352
1996 Hartsough MT, Frey RS, Zipfel PA, Buard A, Cook SJ, McCormick F, Mulder KM. Altered transforming growth factor signaling in epithelial cells when ras activation is blocked. The Journal of Biological Chemistry. 271: 22368-75. PMID 8798398 DOI: 10.1074/Jbc.271.37.22368  0.46
1996 McCormick F, Wittinghofer A. Interactions between ras proteins and their effectors Current Opinion in Biotechnology. 7: 449-456. PMID 8768906 DOI: 10.1016/S0958-1669(96)80123-6  0.397
1996 Symons M, Derry JMJ, Karlak B, Jiang S, Lemahieu V, McCormick F, Francke U, Abo A. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization Cell. 84: 723-734. PMID 8625410 DOI: 10.1016/S0092-8674(00)81050-8  0.311
1996 Porfiri E, McCormick F. Regulation of epidermal growth factor receptor signaling by phosphorylation of the Ras exchange factor hSOS1 Journal of Biological Chemistry. 271: 5871-5877. PMID 8621459 DOI: 10.1074/Jbc.271.10.5871  0.42
1996 Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nature Genetics. 12: 144-8. PMID 8563751 DOI: 10.1038/Ng0296-144  0.346
1996 Qiu RG, Chen J, McCormick F, Symons M. A role for Rho in Ras transformation. Proceedings of the National Academy of Sciences of the United States of America. 92: 11781-5. PMID 8524848 DOI: 10.1073/Pnas.92.25.11781  0.407
1996 Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A, McCormick F. The Candidates Speak At the invitation of Science, President Bill Clinton and Senator Bob Dole have responded to a series of questions regarding science policy Science. 274: 361-366. DOI: 10.1126/Science.274.5286.361  0.354
1996 Eccleston A, Fernandez-Sarabia MJ, McCormick F. CHARACTERISATION OF THE BCL-2 INTERACTING PROTEIN, R-RAS Biochemical Society Transactions. 24: 602S-602S. DOI: 10.1042/Bst024602S  0.342
1996 Cook S, Beltman J, McMahon M, McCormick F. DIFFERENTIAL REQUIREMENT FOR THE MEK/ERK CASCADE IN REGULATING FOS AND JUN EXPRESSION BY LPA AND EGF IN RAT-1 CELLS Biochemical Society Transactions. 24: 580S-580S. DOI: 10.1042/Bst024580S  0.315
1996 Beltman J, McCormick F, Cook S. THE PKC-INDEPENDENT ACTIONS OF Ro-31-8220 HELP DEFINE THE ROLE OF ERK AND JNK IN IMMEDIATE EARLY GENE EXPRESSION Biochemical Society Transactions. 24: 579S-579S. DOI: 10.1042/Bst024579Sc  0.3
1996 Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K. Erratum: Corrigendum: Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells Nature Genetics. 12: 458-458. DOI: 10.1038/Ng0496-458C  0.424
1995 McCormick F. Ras-related proteins in signal transduction and growth control Molecular Reproduction and Development. 42: 500-506. PMID 8607982 DOI: 10.1002/Mrd.1080420419  0.455
1995 Bollag G, McCormick F. Purification of recombinant Ras GTPase-activating proteins Methods in Enzymology. 255: 21-30. PMID 8524104 DOI: 10.1016/S0076-6879(95)55005-4  0.399
1995 Bollag G, McCormick F. Intrinsic and GTPase-activating protein-stimulated Ras GTPase assays Methods in Enzymology. 255: 161-170. PMID 8524100 DOI: 10.1016/S0076-6879(95)55020-8  0.392
1995 Nassar N, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature. 375: 554-60. PMID 7791872 DOI: 10.1038/375554A0  0.394
1995 McCormick F. Ras signaling and NF1 Current Opinion in Genetics and Development. 5: 51-55. PMID 7749326 DOI: 10.1016/S0959-437X(95)90053-5  0.416
1995 Qiu RG, Chen J, Kirn D, McCormick F, Symons M. An essential role for Rac in Ras transformation. Nature. 374: 457-9. PMID 7700355 DOI: 10.1038/374457A0  0.422
1995 Bryant SS, Briggs S, Smithgall TE, Martin GA, McCormick F, Chang - JH, Parsons SJ, Jove R. Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein Journal of Biological Chemistry. 270: 17947-17952. PMID 7629101 DOI: 10.1074/Jbc.270.30.17947  0.398
1995 Martin G, Bollag G, McCormick F, Abo A. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. The Embo Journal. 14: 1970-1978. DOI: 10.1002/J.1460-2075.1995.Tb07189.X  0.338
1995 Braselmann S, McCormick F. Bcr and Raf form a complex in vivo via 14‐3‐3 proteins. The Embo Journal. 14: 4839-4848. DOI: 10.1002/J.1460-2075.1995.Tb00165.X  0.326
1994 Shannon KM, O'Connell P, Martin GA, Paderanga D, Olson K, Dinndorf P, McCormick F. Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. The New England Journal of Medicine. 330: 597-601. PMID 8302341 DOI: 10.1056/Nejm199403033300903  0.322
1994 Mitsudomi T, Friedman E, Gejman PV, McCormick F, Gazdar AF. Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines. Human Genetics. 93: 27-31. PMID 8270251 DOI: 10.1007/Bf00218908  0.44
1994 Cook S, McCormick F. Ras blooms on sterile ground Nature. 369: 361-362. PMID 8196762 DOI: 10.1038/369361A0  0.358
1994 McCormick F. Activators and effectors of ras p21 proteins Current Opinion in Genetics and Development. 4: 71-76. PMID 8193543 DOI: 10.1016/0959-437X(94)90093-0  0.443
1994 Freed E, Symons M, Macdonald SG, McCormick F, Ruggieri R. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science (New York, N.Y.). 265: 1713-6. PMID 8085158 DOI: 10.1126/Science.8085158  0.43
1994 Ruggieri R, Macdonald SG, Callow M, McCormick F. Raf-1 interferes with Ras and Rap1A effector functions in yeast. Molecular Biology of the Cell. 5: 173-81. PMID 8019003 DOI: 10.1091/Mbc.5.2.173  0.413
1994 Spaargaren M, Martin GA, McCormick F, Fernandez-Sarabia MJ, Bischoff JR. The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner. The Biochemical Journal. 303-7. PMID 8002932 DOI: 10.1042/Bj3000303  0.395
1994 McCormick F. Raf: the holy grail of Ras biology? Trends in Cell Biology. 4: 347-350. DOI: 10.1016/0962-8924(94)90075-2  0.445
1993 Bollag G, McCormick F, Clark R. Characterization of full-length neurofibromin: Tubulin inhibits Ras GAP activity Embo Journal. 12: 1923-1927. PMID 8491185 DOI: 10.1002/J.1460-2075.1993.Tb05841.X  0.449
1993 Macdonald SG, Crews CM, Wu L, Driller J, Clark R, Erikson RL, McCormick F. Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Molecular and Cellular Biology. 13: 6615-20. PMID 8413257 DOI: 10.1128/mcb.13.11.6615-6620.1993  0.388
1993 Friedman E, Gejman PV, Martin GA, McCormick F. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. Nature Genetics. 5: 242-7. PMID 8275088 DOI: 10.1038/Ng1193-242  0.372
1993 Boguski MS, McCormick F. Proteins regulating Ras and its relatives Nature. 366: 643-654. PMID 8259209 DOI: 10.1038/366643A0  0.426
1993 Cook SJ, McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science (New York, N.Y.). 262: 1069-72. PMID 7694367 DOI: 10.1126/Science.7694367  0.443
1993 McCormick F. How receptors turn Ras on Nature. 362: 15-16. DOI: 10.1038/363015A0  0.341
1993 Cook S, Rubinfeld B, Albert I, McCormick F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. The Embo Journal. 12: 3475-3485. DOI: 10.1002/J.1460-2075.1993.Tb06022.X  0.442
1992 Zhang K, Papageorge AG, Martin P, Vass WC, Olah Z, Polakis PG, McCormick F, Lowy DR. Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins. Science (New York, N.Y.). 254: 1630-4. PMID 1749934 DOI: 10.1126/Science.1749934  0.4
1992 Martin GA, Yatani A, Clark R, Conroy L, Polakis P, Brown AM, McCormick F. GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents. Science (New York, N.Y.). 255: 192-4. PMID 1553544 DOI: 10.1126/Science.1553544  0.404
1992 McCabe PC, Haubruck H, Polakis P, McCormick F, Innis MA. Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae. Molecular and Cellular Biology. 12: 4084-92. PMID 1508205 DOI: 10.1128/MCB.12.9.4084  0.306
1992 Bollag G, McCormick F. GTPase activating proteins Seminars in Cancer Biology. 3: 199-208. PMID 1421164 DOI: 10.1007/978-3-642-78267-1_23  0.437
1992 Goretzki PE, Lyons J, Stacy-Phipps S, Rosenau W, Demeure M, Clark OH, McCormick F, Röher HD, Bourne HR. Mutational activation of RAS and GSP oncogenes in differentiated thyroid cancer and their biological implications. World Journal of Surgery. 16: 576-81; discussion 5. PMID 1413827 DOI: 10.1007/Bf02067325  0.398
1992 Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P. Localization of the rap1GAP Catalytic Domain and Sites of Phosphorylation by Mutational Analysis Molecular and Cellular Biology. 12: 4634-4642. PMID 1406653 DOI: 10.1128/Mcb.12.10.4634  0.319
1992 Polakis P, McCormick F. Interactions between p21(ras) proteins and their GTPase activating proteins Cancer Surveys. 12: 25-42. PMID 1386285  0.327
1992 Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams LT. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways Cell. 69: 413-423. PMID 1374684 DOI: 10.1016/0092-8674(92)90444-H  0.335
1992 McCormick F. Coupling of ras p21 signalling and GTP hydrolysis by GTPase activating proteins Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 336: 43-47; discussion 47. PMID 1351295 DOI: 10.1098/Rstb.1992.0042  0.438
1991 Chang SE, Bhatia P, Johnson NW, Morgan PR, McCormick F, Young B, Hiorns L. Ras mutations in United Kingdom examples of oral malignancies are infrequent. International Journal of Cancer. 48: 409-412. PMID 2040536 DOI: 10.1002/Ijc.2910480318  0.373
1991 Rubinfeld B, Wong G, Bekesi E, Wood A, Heimer E, McCormick F, Polakis P. A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21ras stimulation and promotes guanine nucleotide exchange. International Journal of Peptide and Protein Research. 38: 47-53. PMID 1938104 DOI: 10.1111/J.1399-3011.1991.Tb01408.X  0.387
1991 Bollag G, McCormick F. Differential regulation of rasGAP and neurofibromatosis gene product activities Nature. 351: 576-579. PMID 1904555 DOI: 10.1038/351576A0  0.389
1991 Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell. 65: 1033-1042. PMID 1904317 DOI: 10.1016/0092-8674(91)90555-D  0.406
1991 Han JW, Mccormick F, Macara IG. Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids Science. 252: 576-579. PMID 1902323 DOI: 10.1126/Science.1902323  0.406
1991 Buss JE, Quilliam LA, Kato K, Casey PJ, Solski PA, Wong G, Clark R, McCormick F, Bokoch GM, Der CJ. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Molecular and Cellular Biology. 11: 1523-30. PMID 1899909 DOI: 10.1128/Mcb.11.3.1523  0.418
1991 Polakis PG, Rubinfeld B, Evans T, McCormick F. Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 239-43. PMID 1846040 DOI: 10.1073/Pnas.88.1.239  0.34
1991 McCormick F. Brief report. GTP-binding proteins as oncogenes in human tumors Environmental Health Perspectives. 93: 17-18. PMID 1773789 DOI: 10.2307/3431162  0.451
1991 Haubruck H, McCormick F. Ras p21: effects and regulation Bba - Reviews On Cancer. 1072: 215-229. PMID 1751548 DOI: 10.1016/0304-419X(91)90015-D  0.353
1991 Bollag G, McCormick F. Regulators and effectors of ras proteins Annual Review of Cell Biology. 7: 601-632. PMID 1667084 DOI: 10.1146/Annurev.Cb.07.110191.003125  0.404
1991 Ruggieri R, McCormick F. Ras and the awd couple Nature. 353: 390-391. PMID 1654523 DOI: 10.1038/353390A0  0.341
1991 Bollag G, Haubruck H, McCormick F. Chapter 26. Regulation of the ras GTPase Cycle Annual Reports in Medicinal Chemistry. 26: 249-258. DOI: 10.1016/S0065-7743(08)61213-0  0.464
1991 Dominguez I, Marshall M, Gibbs J, García de Herreros A, Cornet M, Graziani G, Diaz-Meco M, Johansen T, McCormick F, Moscat J. Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. The Embo Journal. 10: 3215-3220. DOI: 10.1002/J.1460-2075.1991.Tb04884.X  0.334
1990 McCormick F. GAP as ras effector or negative regulator? Molecular Carcinogenesis. 3: 185-187. PMID 2206281 DOI: 10.1002/Mc.2940030404  0.381
1990 Zhang K, DeClue JE, Vass WC, Papageorge AG, McCormick F, Lowy DR. Suppression of c-ras transformation by GTPase-activating protein. Nature. 346: 754-6. PMID 2201922 DOI: 10.1038/346754A0  0.436
1990 Frech M, John J, Pizon V, Chardin P, Tavitian A, Clark R, McCormick F, Wittinghofer A. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science (New York, N.Y.). 249: 169-71. PMID 2164710 DOI: 10.1126/Science.2164710  0.416
1990 Quilliam LA, Der CJ, Clark R, O'Rourke EC, Zhang K, McCormick F, Bokoch GM. Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Molecular and Cellular Biology. 10: 2901-8. PMID 2160589 DOI: 10.1128/Mcb.10.6.2901  0.415
1990 Kaplan DR, Morrison DK, Wong G, McCormick F, Williams LT. PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex Cell. 61: 125-133. PMID 2156626 DOI: 10.1016/0092-8674(90)90220-9  0.388
1990 Ellis C, Moran M, McCormick F, Pawson T. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 343: 377-81. PMID 1689011 DOI: 10.1038/343377A0  0.359
1989 Valverius EM, Bates SE, Stampfer MR, Clark R, McCormick F, Salomon DS, Lippman ME, Dickson RB. Transforming growth factor alpha production and epidermal growth factor receptor expression in normal and oncogene transformed human mammary epithelial cells. Molecular Endocrinology (Baltimore, Md.). 3: 203-14. PMID 2783757 DOI: 10.1210/Mend-3-1-203  0.303
1989 Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. Genetic analysis of mammalian GAP expressed in yeast. Cell. 59: 681-6. PMID 2684416 DOI: 10.1016/0092-8674(89)90014-7  0.388
1989 Meyers FJ, Gumerlock PH, Kokoris SP, White RWD, McCormick F. Human bladder and colon carcinomas contain activated ras p21. Specific detection of twelfth codon mutants. Cancer. 63: 2177-2181. PMID 2655864 DOI: 10.1002/1097-0142(19890601)63:11<2177::Aid-Cncr2820631119>3.0.Co;2-V  0.442
1989 Burk SC, Papastavros MZ, McCormick F, Redfield AG. Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR. Proceedings of the National Academy of Sciences of the United States of America. 86: 817-20. PMID 2644645 DOI: 10.1073/Pnas.86.3.817  0.314
1989 McCormick F. Ras GTPase activating protein: Signal transmitter and signal terminator Cell. 56: 5-8. PMID 2535967 DOI: 10.1016/0092-8674(89)90976-8  0.429
1989 McCormick F. Gasp: not just another oncogene Nature. 340: 678-679. PMID 2505083 DOI: 10.1038/340678A0  0.405
1988 Farr CJ, Saiki RK, Erlich HA, McCormick F, Marshall CJ. Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proceedings of the National Academy of Sciences of the United States of America. 85: 1629-33. PMID 3278322 DOI: 10.1073/Pnas.85.5.1629  0.353
1988 Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science (New York, N.Y.). 240: 518-21. PMID 2833817 DOI: 10.1126/Science.2833817  0.426
1987 Korn LJ, Siebel CW, McCormick F, Roth RA. Ras p21 as a potential mediator of insulin action in Xenopus oocytes. Science (New York, N.Y.). 236: 840-3. PMID 3554510 DOI: 10.1126/Science.3554510  0.327
1987 Trahey M, McCormick F. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants Science. 238: 542-545. PMID 2821624 DOI: 10.1126/Science.2821624  0.391
1985 Clark R, Wong G, Arnheim N, Nitecki D, McCormick F. Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding Proceedings of the National Academy of Sciences of the United States of America. 82: 5280-5284. PMID 3927300 DOI: 10.1073/Pnas.82.16.5280  0.364
1985 Feramisco JR, Clark R, Wong G, Arnheim N, Milley R, McCormick F. Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein Nature. 314: 639-642. PMID 2581140 DOI: 10.1038/314639A0  0.341
1984 Ringold GM, Dieckmann B, Vannice JL, Trahey M, McCormick F. Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 3964-8. PMID 6330726 DOI: 10.1073/Pnas.81.13.3964  0.302
1981 McCormick F, Clark R, Harlow E, Tjian R. SV40 T antigen binds specifically to a cellular 53 K protein in vitro. Nature. 292: 63-5. PMID 6268984 DOI: 10.1038/292063A0  0.483
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