| Year |
Citation |
Score |
| 2022 |
Sule A, Golding SE, Ahmad SF, Watson J, Ahmed MH, Kellogg GE, Bernas T, Koebley S, Reed JC, Povirk LF, Valerie K. ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response. Cellular and Molecular Life Sciences : Cmls. 79: 603. PMID 36434396 DOI: 10.1007/s00018-022-04550-5 |
0.45 |
|
| 2018 |
Kawale AS, Akopiants K, Valerie K, Ruis B, Hendrickson EA, Huang SN, Pommier Y, Povirk LF. TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining. Nucleic Acids Research. PMID 30113698 DOI: 10.1093/Nar/Gky694 |
0.629 |
|
| 2018 |
Chalasani SL, Kawale AS, Akopiants K, Yu Y, Fanta M, Weinfeld M, Povirk LF. Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase. Dna Repair. 68: 12-24. PMID 29807321 DOI: 10.1016/J.Dnarep.2018.05.002 |
0.549 |
|
| 2017 |
Kawale AS, Povirk LF. Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation. Nucleic Acids Research. PMID 29216365 DOI: 10.1093/Nar/Gkx1219 |
0.578 |
|
| 2017 |
Menon V, Povirk LF. XLF/Cernunnos: An important but puzzling participant in the nonhomologous end joining DNA repair pathway. Dna Repair. 58: 29-37. PMID 28846869 DOI: 10.1016/J.Dnarep.2017.08.003 |
0.639 |
|
| 2016 |
Menon V, Povirk LF. End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair. Dna Repair. 43: 57-68. PMID 27262532 DOI: 10.1016/J.Dnarep.2016.05.011 |
0.622 |
|
| 2016 |
Almohaini M, Chalasani SL, Bafail D, Akopiants K, Zhou T, Yannone SM, Ramsden DA, Hartman MC, Povirk LF. Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair. Dna Repair. 41: 16-26. PMID 27049455 DOI: 10.1016/J.Dnarep.2016.03.003 |
0.592 |
|
| 2016 |
Alotaibi M, Sharma K, Saleh T, Povirk LF, Hendrickson EA, Gewirtz DA. Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiation Research. PMID 26934368 DOI: 10.1667/Rr14202.1 |
0.505 |
|
| 2016 |
Zhou L, Chen S, Zhang Y, Kmieciak M, Leng Y, Li L, Lin H, Rizzo KA, Dumur CI, Ferreira-Gonzalez A, Rahmani M, Povirk L, Chalasani S, Berger AJ, Dai Y, et al. The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR. Blood. PMID 26851293 DOI: 10.1182/Blood-2015-06-653717 |
0.364 |
|
| 2016 |
Alotaibi MR, Sharma K, Saleh T, Povirk L, Hendrickson E, Gewirtz D. Abstract 2848: Autophagy, senescence and proliferative recovery subsequent to DNA damage in radiation sensitization by PARP inhibition Cancer Research. 76: 2848-2848. DOI: 10.1158/1538-7445.Am2016-2848 |
0.508 |
|
| 2015 |
Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget. PMID 26320175 DOI: 10.18632/Oncotarget.4876 |
0.473 |
|
| 2015 |
Peterson EJ, Menon VR, Gatti L, Kipping R, Dewasinghe D, Perego P, Povirk LF, Farrell NP. Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction. Molecular Pharmaceutics. 12: 287-97. PMID 25407898 DOI: 10.1021/Mp5006867 |
0.538 |
|
| 2015 |
Alotaibi MR, Povirk L, Gewirtz D. Abstract 993: The relationship between autophagy, senescence, and DNA repair Cancer Research. 75: 993-993. DOI: 10.1158/1538-7445.Am2015-993 |
0.54 |
|
| 2015 |
Bafail D, Chalasani SL, mohaini MA, Akopiants K, Povirk LF. Abstract 3028: Tolerance and intolerance of proximal thymine glycol in DNA double-strand break repair by nonhomologous end joining Cancer Research. 75: 3028-3028. DOI: 10.1158/1538-7445.Am2015-3028 |
0.557 |
|
| 2014 |
Menon V, Povirk L. Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). Sub-Cellular Biochemistry. 85: 321-36. PMID 25201202 DOI: 10.1007/978-94-017-9211-0_17 |
0.612 |
|
| 2014 |
Akopiants K, Mohapatra S, Menon V, Zhou T, Valerie K, Povirk LF. Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells. Nucleic Acids Research. 42: 3125-37. PMID 24371269 DOI: 10.1093/Nar/Gkt1347 |
0.661 |
|
| 2014 |
Alotaibi MR, Gewirtz D, Povirk L. Abstract 2385: Involvement of autophagy and senescence in DNA repair in irradiated tumor cells Cancer Research. 74: 2385-2385. DOI: 10.1158/1538-7445.Am2014-2385 |
0.566 |
|
| 2013 |
Menon VR, Peterson EJ, Valerie K, Farrell NP, Povirk LF. Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest. Biochemical Pharmacology. 86: 1708-20. PMID 24161784 DOI: 10.1016/J.Bcp.2013.10.012 |
0.409 |
|
| 2013 |
Mohapatra S, Yannone SM, Lee SH, Hromas RA, Akopiants K, Menon V, Ramsden DA, Povirk LF. Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases. Dna Repair. 12: 422-32. PMID 23602515 DOI: 10.1016/J.Dnarep.2013.03.005 |
0.675 |
|
| 2013 |
Menon V, Peterson E, Deb S, Povirk L, Farrell N. Abstract 3427: The dinuclear platinum agent, BBR3610-DACH, exhibits a significant anti-proliferative effect: Regulation of G1/S and G2/M cell cycle arrest and apoptosis induction. Cancer Research. 73: 3427-3427. DOI: 10.1158/1538-7445.Am2013-3427 |
0.411 |
|
| 2012 |
Povirk LF. Processing of damaged DNA ends for double-strand break repair in mammalian cells. Isrn Molecular Biology. 2012. PMID 24236237 DOI: 10.5402/2012/345805 |
0.613 |
|
| 2011 |
Dever SM, Golding SE, Rosenberg E, Adams BR, Idowu MO, Quillin JM, Valerie N, Xu B, Povirk LF, Valerie K. Mutations in the BRCT binding site of BRCA1 result in hyper-recombination. Aging. 3: 515-32. PMID 21666281 |
0.328 |
|
| 2011 |
Mohapatra S, Kawahara M, Khan IS, Yannone SM, Povirk LF. Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis. Nucleic Acids Research. 39: 6500-10. PMID 21531702 DOI: 10.1093/Nar/Gkr257 |
0.52 |
|
| 2011 |
Khalil A, Morgan RN, Adams BR, Golding SE, Dever SM, Rosenberg E, Povirk LF, Valerie K. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle (Georgetown, Tex.). 10: 481-91. PMID 21263216 DOI: 10.4161/Cc.10.3.14713 |
0.504 |
|
| 2010 |
Adams BR, Hawkins AJ, Povirk LF, Valerie K. ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells. Aging. 2: 582-96. PMID 20844317 |
0.748 |
|
| 2010 |
Zhou RZ, Akopiants K, Povirk LF. Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break. Radiation Research. 174: 274-9. PMID 20726725 DOI: 10.1667/Rr2050.1 |
0.598 |
|
| 2010 |
Bebenek K, Garcia-Diaz M, Zhou RZ, Povirk LF, Kunkel TA. Loop 1 modulates the fidelity of DNA polymerase lambda. Nucleic Acids Research. 38: 5419-31. PMID 20435673 DOI: 10.1093/Nar/Gkq261 |
0.489 |
|
| 2010 |
Taylor EM, Cecillon SM, Bonis A, Chapman JR, Povirk LF, Lindsay HD. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. Nucleic Acids Research. 38: 441-54. PMID 19892829 DOI: 10.1093/Nar/Gkp905 |
0.633 |
|
| 2010 |
Hawkins AJ, White DE, Golding SE, Akopiants K, Rauscher FJ, Povirk LF, Valerie K. Abstract 3923: ATM and KAP1 are required for nonhomologous end-joining in transcriptionally active chromatin Cancer Research. 70: 3923-3923. DOI: 10.1158/1538-7445.Am10-3923 |
0.757 |
|
| 2010 |
Kabolizadeh P, Kipping R, Menon V, Ryan J, Peterson E, Povirk L, Farrell N. Abstract 2494: A non-covalent binding platinum drug, TriplatinNC, induces a G1 phase cell cycle arrest and p53-independent mechanisms of apoptosis Cancer Research. 70: 2494-2494. DOI: 10.1158/1538-7445.Am10-2494 |
0.366 |
|
| 2009 |
Golding SE, Rosenberg E, Valerie N, Hussaini I, Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, O'Connor MJ, Povirk LF, van Meter T, Valerie K. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Molecular Cancer Therapeutics. 8: 2894-902. PMID 19808981 DOI: 10.1158/1535-7163.Mct-09-0519 |
0.408 |
|
| 2009 |
Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF. Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. Dna Repair. 8: 901-11. PMID 19505854 DOI: 10.1016/J.Dnarep.2009.05.003 |
0.686 |
|
| 2009 |
Akopiants K, Zhou RZ, Mohapatra S, Valerie K, Lees-Miller SP, Lee KJ, Chen DJ, Revy P, de Villartay JP, Povirk LF. Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 37: 4055-62. PMID 19420065 DOI: 10.1093/Nar/Gkp283 |
0.63 |
|
| 2009 |
Golding SE, Morgan RN, Adams BR, Hawkins AJ, Povirk LF, Valerie K. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biology & Therapy. 8: 730-8. PMID 19252415 DOI: 10.4161/Cbt.8.8.7927 |
0.707 |
|
| 2009 |
Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF. In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation. Dna Repair. 8: 654-63. PMID 19211312 DOI: 10.1016/J.Dnarep.2008.12.012 |
0.737 |
|
| 2008 |
Yannone SM, Khan IS, Zhou RZ, Zhou T, Valerie K, Povirk LF. Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Research. 36: 3354-65. PMID 18440975 DOI: 10.1093/Nar/Gkn205 |
0.664 |
|
| 2008 |
Zhou RZ, Blanco L, Garcia-Diaz M, Bebenek K, Kunkel TA, Povirk LF. Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts. Nucleic Acids Research. 36: 2895-905. PMID 18385158 DOI: 10.1093/Nar/Gkn126 |
0.553 |
|
| 2007 |
Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K. Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 35: 3869-78. PMID 17526517 DOI: 10.1093/Nar/Gkm339 |
0.522 |
|
| 2007 |
Golding SE, Rosenberg E, Neill S, Dent P, Povirk LF, Valerie K. Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Research. 67: 1046-53. PMID 17283137 DOI: 10.1158/0008-5472.Can-06-2371 |
0.397 |
|
| 2007 |
Povirk LF, Zhou T, Zhou R, Cowan MJ, Yannone SM. Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. The Journal of Biological Chemistry. 282: 3547-58. PMID 17121861 DOI: 10.1074/Jbc.M607745200 |
0.63 |
|
| 2006 |
Miao ZH, Agama K, Sordet O, Povirk L, Kohn KW, Pommier Y. Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes. Dna Repair. 5: 1489-94. PMID 16935573 DOI: 10.1016/J.Dnarep.2006.07.004 |
0.546 |
|
| 2006 |
Povirk LF. Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks. Dna Repair. 5: 1199-212. PMID 16822725 DOI: 10.1016/J.Dnarep.2006.05.016 |
0.657 |
|
| 2005 |
Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA. p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells. International Journal of Radiation Biology. 81: 445-58. PMID 16308915 DOI: 10.1080/09553000500168549 |
0.344 |
|
| 2005 |
Jones KR, Gewirtz DA, Yannone SM, Zhou S, Schatz DG, Valerie K, Povirk LF. Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Molecular Cancer Therapeutics. 4: 1541-7. PMID 16227403 DOI: 10.1158/1535-7163.Mct-05-0193 |
0.555 |
|
| 2005 |
Zhou T, Povirk LF. Extreme cytotoxicity and susceptibility to hprt mutagenesis in Ku-deficient xrs-6 cells treated with bleomycin in plateau phase. Mutagenesis. 20: 39-44. PMID 15671058 DOI: 10.1093/Mutage/Gei006 |
0.456 |
|
| 2005 |
Zhou T, Lee JW, Tatavarthi H, Lupski JR, Valerie K, Povirk LF. Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). Nucleic Acids Research. 33: 289-97. PMID 15647511 DOI: 10.1093/Nar/Gki170 |
0.623 |
|
| 2004 |
Farrell N, Povirk LF, Dange Y, DeMasters G, Gupta MS, Kohlhagen G, Khan QA, Pommier Y, Gewirtz DA. Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells. Biochemical Pharmacology. 68: 857-66. PMID 15294448 DOI: 10.1016/J.Bcp.2004.05.023 |
0.53 |
|
| 2004 |
Golding SE, Rosenberg E, Khalil A, McEwen A, Holmes M, Neill S, Povirk LF, Valerie K. Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. The Journal of Biological Chemistry. 279: 15402-10. PMID 14744854 DOI: 10.1074/Jbc.M314191200 |
0.489 |
|
| 2004 |
Lee JW, Blanco L, Zhou T, Garcia-Diaz M, Bebenek K, Kunkel TA, Wang Z, Povirk LF. Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. The Journal of Biological Chemistry. 279: 805-11. PMID 14561766 DOI: 10.1074/Jbc.M307913200 |
0.559 |
|
| 2003 |
Lee JW, Inamdar KV, Hannah MF, Lees-Miller SP, Povirk LF. DNA end sequestration by DNA-dependent protein kinase and end joining of sterically constrained substrates in whole-cell extracts. Environmental and Molecular Mutagenesis. 42: 279-87. PMID 14673873 DOI: 10.1002/Em.10197 |
0.795 |
|
| 2003 |
Valerie K, Povirk LF. Regulation and mechanisms of mammalian double-strand break repair. Oncogene. 22: 5792-812. PMID 12947387 DOI: 10.1038/Sj.Onc.1206679 |
0.407 |
|
| 2003 |
Lee JW, Yannone SM, Chen DJ, Povirk LF. Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Research. 63: 22-4. PMID 12517771 |
0.595 |
|
| 2002 |
Yu Y, Inamdar KV, Turner K, Jackson-Cook CK, Povirk LF. Base substitutions, targeted single-base deletions, and chromosomal translocations induced by bleomycin in plateau-phase mammary epithelial cells. Radiation Research. 158: 327-38. PMID 12175310 DOI: 10.1667/0033-7587(2002)158[0327:Bstsbd]2.0.Co;2 |
0.761 |
|
| 2002 |
Wang P, Lee JW, Yu Y, Turner K, Zou Y, Jackson-Cook CK, Povirk LF. Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome. Nucleic Acids Research. 30: 2639-46. PMID 12060680 DOI: 10.1093/Nar/Gkf369 |
0.643 |
|
| 2002 |
Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF. Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. The Journal of Biological Chemistry. 277: 27162-8. PMID 12023295 DOI: 10.1074/jbc.M204688200 |
0.798 |
|
| 2002 |
Inamdar KV, Yu Y, Povirk LF. Resistance of 3'-phosphoglycolate DNA ends to digestion by mammalian DNase III. Radiation Research. 157: 306-11. PMID 11839093 DOI: 10.1667/0033-7587(2002)157[0306:Ropdet]2.0.Co;2 |
0.81 |
|
| 2002 |
Inamdar KV, Yu Y, Povirk LF. Resistance of 3′-phosphoglycolate DNA ends to digestion by mammalian DNase III Radiation Research. 157: 306-311. |
0.799 |
|
| 2001 |
Chen S, Inamdar KV, Pfeiffer P, Feldmann E, Hannah MF, Yu Y, Lee JW, Zhou T, Lees-Miller SP, Povirk LF. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity. The Journal of Biological Chemistry. 276: 24323-30. PMID 11309379 DOI: 10.1074/Jbc.M010544200 |
0.824 |
|
| 2001 |
Chen S, Hannis JC, Flora JW, Muddiman DC, Charles K, Yu Y, Povirk LF. Homogeneous preparations of 3'-phosphoglycolate-terminated oligodeoxynucleotides from bleomycin-treated DNA as verified by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Analytical Biochemistry. 289: 274-80. PMID 11161322 DOI: 10.1006/Abio.2000.4936 |
0.608 |
|
| 1999 |
Patteson K, Wang P, Povirk LF. Enhanced amsacrine-induced mutagenesis in plateau-phase Chinese hamster ovary cells, with targeting of +1 frameshifts to free 3' ends of topoisomerase II cleavable complexes Cancer Research. 59: 3682-3688. PMID 10446982 |
0.332 |
|
| 1998 |
Charles K, Povirk LF. Action of bleomycin on structural mimics of intermediates in DNA double-strand cleavage. Chemical Research in Toxicology. 11: 1580-5. PMID 9860504 DOI: 10.1021/Tx980154G |
0.573 |
|
| 1998 |
Povirk LF. Rapid communication: A highly conservative, cyclically permuted, non- homologous exchange among three unrelated DNA sequences in bleomycin-treated CHO cells International Journal of Radiation Biology. 74: 561-564. PMID 9848274 DOI: 10.1080/095530098141131 |
0.383 |
|
| 1998 |
Gu XY, Weinfeld MA, Povirk LF. Implication of DNA-dependent protein kinase in an early, essential, local phosphorylation event during end-joining of DNA double-strand breaks in vitro Biochemistry. 37: 9827-9835. PMID 9657696 DOI: 10.1021/Bi980198O |
0.602 |
|
| 1997 |
Zhou RH, Wang P, Zou Y, Jackson-Cook CK, Povirk LF. A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells Cancer Research. 57: 4699-4702. PMID 9354424 |
0.359 |
|
| 1997 |
Wang P, Zhou RH, Zou Y, Jackson-Cook CK, Povirk LF. Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends Proceedings of the National Academy of Sciences of the United States of America. 94: 12018-12023. PMID 9342355 DOI: 10.1073/Pnas.94.22.12018 |
0.497 |
|
| 1997 |
Weinfeld M, Chaudhry MA, D'Amours D, Pelletier JD, Poirier GG, Povirk LF, Lees-Miller SP. Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiation Research. 148: 22-8. PMID 9216614 DOI: 10.2307/3579534 |
0.641 |
|
| 1997 |
Suh D, Wilson DM, Povirk LF. 3'-Phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends Nucleic Acids Research. 25: 2495-2500. PMID 9171104 DOI: 10.1093/Nar/25.12.2495 |
0.619 |
|
| 1997 |
Suh D, Povirk LF. Mapping of the cleavage-associated bleomycin binding site on DNA with a new method based on site-specific blockage of the minor groove with N2- isobutyrylguanine Biochemistry. 36: 4248-4257. PMID 9100020 DOI: 10.1021/Bi962957D |
0.493 |
|
| 1997 |
Wang P, Povirk LF. Targeted base substitutions and small deletions induced by neocarzinostatin at the APRT locus in plateau-phase CHO cells Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 373: 17-29. PMID 9015149 DOI: 10.1016/S0027-5107(96)00182-0 |
0.546 |
|
| 1996 |
Bennett RAO, Gu XY, Povirk LF. Construction of a vector containing a site-specific DNA double-strand break with 3'-phosphoglycolate termini and analysis of the products of end-joining in CV-1 cells International Journal of Radiation Biology. 70: 623-636. PMID 8980659 DOI: 10.1080/095530096144509 |
0.482 |
|
| 1996 |
Pomponio RJ, Narasimhan V, Reynolds TR, Buck GA, Povirk LF, Wolf B. Deletion/insertion mutation that causes biotinidase deficiency may result from the formation of a quasipalindromic structure Human Molecular Genetics. 5: 1657-1661. PMID 8894703 |
0.315 |
|
| 1996 |
Povirk LF. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediynes Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 355: 71-89. PMID 8781578 DOI: 10.1016/0027-5107(96)00023-1 |
0.58 |
|
| 1996 |
Gu XY, Bennett RAO, Povirk LF. End-joining of free radical-mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceding removal of damaged 3' termini Journal of Biological Chemistry. 271: 19660-19663. PMID 8702667 DOI: 10.1074/jbc.271.33.19660 |
0.497 |
|
| 1995 |
Bunch RT, Gewirtz DA, Povirk LF. Ionizing radiation-induced DNA Strand breakage and rejoining in specific genomic regions as determined by an alkaline unwinding/southern blotting method International Journal of Radiation Biology. 68: 553-562. PMID 7490505 DOI: 10.1080/09553009514551541 |
0.507 |
|
| 1995 |
Austin MJF, Bunch RT, Povirk LF. Selective damage to the active X chromosome by camptothecin and amsacrine as determined by an allele-specific alkaline unwinding assay Biochemical Pharmacology. 50: 1317-1319. PMID 7488252 DOI: 10.1016/0006-2952(95)00247-W |
0.469 |
|
| 1994 |
Bunch RT, Povirk LF, Orr MS, Randolph JK, Fornari FA, Gewirtz DA. Influence of amsacrine (m-AMSA) on bulk and gene-specific DNA damage and c-myc expression in MCF-7 breast tumor cells Biochemical Pharmacology. 47: 317-329. PMID 8304976 DOI: 10.1016/0006-2952(94)90023-X |
0.439 |
|
| 1994 |
Wang P, Bauer GB, Kellogg GE, Abraham DJ, Povirk LF. Effect of distamycin on chlorambucil-induced mutagenesis in pZ189: Evidence of a role for minor groove alkylation at adenine N-3 Mutagenesis. 9: 133-139. PMID 8201946 DOI: 10.1093/Mutage/9.2.133 |
0.45 |
|
| 1994 |
David Jarvis W, Povirk LF, Turner AJ, Traylor RS, Gewirtz DA, Pettit GR, Grant S. Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-d-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells Biochemical Pharmacology. 47: 839-852. PMID 8135859 DOI: 10.1016/0006-2952(94)90484-7 |
0.355 |
|
| 1994 |
Smith BL, Bauer GB, Povirk LF. DNA damage induced by bleomycin, neocarzinostatin, and melphalan in a precisely positioned nucleosome. Asymmetry in protection at the periphery of nucleosome-bound DNA Journal of Biological Chemistry. 269: 30587-30594. PMID 7527033 |
0.535 |
|
| 1994 |
Povirk LF, Bennett RAO, Wang P, Swerdlow PS, Austin MJF. Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells Journal of Molecular Biology. 243: 216-226. PMID 7523683 DOI: 10.1006/jmbi.1994.1649 |
0.456 |
|
| 1994 |
Jarvis WD, Turner AJ, Povirk LF, Traylor RS, Grant S. Induction of Apoptotic DNA Fragmentation and Cell Death in Hl-60 Human Promyelocytic Leukemia Cells by Pharmacological Inhibitors of Protein Kinase C Cancer Research. 54: 1707-1714. PMID 7511048 |
0.422 |
|
| 1993 |
Han YH, Austin MJF, Pommier Y, Povirk LF. Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro Journal of Molecular Biology. 229: 52-66. PMID 8380617 DOI: 10.1006/jmbi.1993.1007 |
0.393 |
|
| 1993 |
Gewirtz DA, Ritke MK, Orr MS, Yalowich JC, Fornari FA, Randolph JK, Povirk LF, Bunch RT. Dissociation between Bulk Damage to DNA and the Antiproliferative Activity of Teniposide (VM-26) in the MCF-7 Breast Tumor Cell Line: Evidence for Induction of Gene-specific Damage and Alterations in Gene Expression Cancer Research. 53: 3547-3554. PMID 8339261 |
0.429 |
|
| 1993 |
Bennett RAO, Swerdlow PS, Povirk LF. Spontaneous cleavage of bleomycin-induced abasic sites in chromatin and their mutagenicity in mammalian shuttle vectors Biochemistry. 32: 3188-3195. PMID 7681328 DOI: 10.1021/Bi00063A034 |
0.435 |
|
| 1992 |
Bunch RT, Gewirtz DA, Povirk LF. A combined alkaline unwinding/Southern blotting assay for measuring low levels of cellular DNA breakage within specific genomic regions Oncology Research. 4: 7-15. PMID 1581618 |
0.478 |
|
| 1992 |
Finley Austin MJ, Han YH, Povirk LF. DNA sequence analysis of mutations induced by melphalan in the CHO aprt locus Cancer Genetics and Cytogenetics. 64: 69-74. PMID 1458453 DOI: 10.1016/0165-4608(92)90326-4 |
0.302 |
|
| 1991 |
Povirk LF. Thermolabile adenine adducts and A-T Base pair substitutions induced by nitrogen mustard analogues in an SV40-based shuttle plasmid Biochemistry. 30: 11515-11521. PMID 1660721 DOI: 10.1021/Bi00113A005 |
0.478 |
|
| 1991 |
Pandey RN, Povirk LF, Wilson JD. Synthesis, cytotoxicity and DNA binding properties of a photoreactive analog of nafidimide (NSC-308847) Clinical Chemistry and Enzymology Communications. 4: 191-201. |
0.41 |
|
| 1990 |
Wang P, Bennett RAO, Povirk LF. Melphalan-induced Mutagenesis in an SV40-based Shuttle Vector: Predominance of AT→ A Transversions Cancer Research. 50: 7527-7531. PMID 2174727 |
0.316 |
|
| 1990 |
Steighner RJ, Povirk LF. Bleomycin-induced DNA lesions at mutational hot spots: Implications for the mechanism of double-strand cleavage Proceedings of the National Academy of Sciences of the United States of America. 87: 8350-8354. PMID 1700429 |
0.421 |
|
| 1990 |
Steighner RJ, Povirk LF. Effect of in vitro cleavage of apurinic/apyrimidinic sites on bleomycin-induced mutagenesis of repackaged lambda phage Mutation Research/Genetic Toxicology. 240: 93-100. PMID 1689007 DOI: 10.1016/0165-1218(90)90012-Q |
0.462 |
|
| 1989 |
Gewirtz DA, Ellis AL, Randolph JK, Yanovich S, Swerdlow PS, Povirk LF, Yalowich JC. Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization. Cancer Communications. 1: 175-80. PMID 2561738 |
0.509 |
|
| 1989 |
Povirk LF, Han YH, Steighner RJ. Structure of bleomycin-induced DNA double-strand breaks: Predominance of blunt ends and single-base 5′ extensions Biochemistry. 28: 5808-5814. PMID 2476175 |
0.475 |
|
| 1988 |
Povirk LF, Houlgrave CW, Han YH. Neocarzinostatin-induced DNA base release accompanied by staggered oxidative cleavage of the complementary strand Journal of Biological Chemistry. 263: 19263-19266. PMID 2974036 |
0.526 |
|
| 1988 |
Povirk LF, Houlgrave CW. Effect of apurinic/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: Specific formation and cleavage of closely opposed lesions in complementary strands Biochemistry. 27: 3850-3857. PMID 2457392 |
0.484 |
|
| 1988 |
Povirk LF, Houlgrave CW. Mutagenesis of bleomycin-damaged lambda phage in SOS-deficient and repair endonuclease-deficient Escherichia coli Environmental and Molecular Mutagenesis. 11: 461-472. PMID 2453358 |
0.315 |
|
| 1987 |
Povirk LF, Goldberg IH. A role for oxidative DNA sugar damage in mutagenesis by neocarzinostatin and bleomycin Biochimie. 69: 815-823. PMID 2447954 DOI: 10.1016/0300-9084(87)90208-2 |
0.674 |
|
| 1987 |
Povirk LF. Bleomycin-induced mutagenesis in repackaged lambda phage: base substitution hotspots at the sequence C-G-C-C Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 180: 1-9. PMID 2442605 DOI: 10.1016/0027-5107(87)90061-3 |
0.371 |
|
| 1986 |
Goldberg IH, Kappen LS, Povirk LF, Chin DH. Molecular mechanism of novel DNA sugar damage by an antitumour protein antibiotic Drugs Under Experimental and Clinical Research. 12: 495-505. PMID 2943568 |
0.449 |
|
| 1986 |
Povirk LF, Goldberg IH. Base substitution mutations induced in the cI gene of lambda phage by neocarzinostatin chromophore: Correlation with depyrimidination hotspots at the sequence AGC Nucleic Acids Research. 14: 1417-1426. PMID 2937016 DOI: 10.1093/Nar/14.3.1417 |
0.568 |
|
| 1985 |
Povirk LF, Goldberg IH. Detection of neocarzinostatin chromophore-deoxyribose adducts as exonuclease-resistant sites in defined-sequence DNA Biochemistry. 24: 4035-4040. PMID 2996589 DOI: 10.1021/Bi00336A035 |
0.742 |
|
| 1985 |
Povirk LF, Goldberg IH. Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: Evidence for a possible role in mutagenesis Proceedings of the National Academy of Sciences of the United States of America. 82: 3182-3186. PMID 2582408 DOI: 10.1073/Pnas.82.10.3182 |
0.675 |
|
| 1984 |
Povirk LF, Goldberg IH. Competition between anaerobic covalent linkage of neocarzinostatin chromophore to deoxyribose in DNA and oxygen-dependent strand breakage and base release Biochemistry. 23: 6304-6311. PMID 6241478 DOI: 10.1021/Bi00321A003 |
0.687 |
|
| 1983 |
Povirk LF, Goldberg IH. Stoichiometric uptake of molecular oxygen and consumption of sulfhydryl groups by neocarzinostatin chromophore bound to DNA Journal of Biological Chemistry. 258: 11763-11767. PMID 6225780 |
0.342 |
|
| 1982 |
Povirk LF, Goldberg IH. Inhibition of mammalian deoxyribonucleic acid synthesis by neocarzinostatin: Selective effect on replicon initiation in CHO cells and resistant synthesis in ataxia telangiectasia fibroblasts Biochemistry. 21: 5857-5862. PMID 6217834 DOI: 10.1021/Bi00266A020 |
0.713 |
|
| 1982 |
Povirk LF, Goldberg IH. Neocarzinostatin chromophore-DNA adducts: Evidence for a covalent linkage to the oxidized C-5′ of deoxyribose Nucleic Acids Research. 10: 6255-6264. PMID 6217447 DOI: 10.1093/Nar/10.20.6255 |
0.575 |
|
| 1982 |
Povirk LF, Goldberg IH. Covalent adducts of DNA and the nonprotein chromophore of neocarzinostatin contain a modified deoxyribose Proceedings of the National Academy of Sciences of the United States of America. 79: 369-373. PMID 6210907 DOI: 10.1073/Pnas.79.2.369 |
0.726 |
|
| 1982 |
Povirk LF, Goldberg IH. Selective inhibition of replicon initiation and relaxation of supercoiling in DNA of mammalian cells by neocarzinostatin Biophysical Journal. 37. |
0.479 |
|
| 1982 |
Povirk LF, Kappen LS, Goldberg IH. Unusual structures in DNA treated with neocarzinostatin chromophore: Thymidine-5'-aldehyde and a chromophore-DNA adduct with a modified deoxyribose Federation Proceedings. 41. |
0.542 |
|
| 1981 |
Povirk LF, Dattagupta N, Warf BC, Goldberg IH. Neocarzinostatin chromophore binds to deoxyribonucleic acid by intercalation Biochemistry. 20: 4007-4014. PMID 6456758 DOI: 10.1021/Bi00517A009 |
0.727 |
|
| 1981 |
Povirk LF, Hogan M, Dattagupta N, Buechner M. Copper(II)·bleomycin, iron(III)·bleomycin, and copper(II)·phleomycin: Comparative study of deoxyribonucleic acid binding Biochemistry. 20: 665-671. PMID 6163448 DOI: 10.1021/Bi00506A034 |
0.402 |
|
| 1980 |
Povirk LF, Goldberg IH. Binding of the nonprotein chromophore of neocarzinostatin to deoxyribonucleic acid Biochemistry. 19: 4773-4780. PMID 6448634 DOI: 10.1021/Bi00562A009 |
0.686 |
|
| 1979 |
Povirk LF. Catalytic release of deoxyribonucleic acid bases by oxidation and reduction of an iron-bleomycin complex 1 Biochemistry. 18: 3989-3995. PMID 90519 DOI: 10.1021/Bi00585A023 |
0.476 |
|
| 1979 |
Povirk LF. Binding of bleomycin to DNA: Intercalation of the bithiazole rings Biochemistry. 18: 96-101. PMID 84680 DOI: 10.1021/Bi00568A015 |
0.573 |
|
| 1978 |
Povirk LF, Köhnlein W, Hutchinson F. Specificity of DNA base release by bleomycin. Biochimica Et Biophysica Acta. 521: 126-33. PMID 82451 DOI: 10.1016/0005-2787(78)90255-1 |
0.599 |
|
| 1977 |
Povirk LF. Localization of Inhibition of replicon initiation to damaged regions of DNA Journal of Molecular Biology. 114: 141-151. PMID 909084 DOI: 10.1016/0022-2836(77)90288-1 |
0.52 |
|
| 1977 |
Povirk LF, Wübter W, Köhnlein W, Hutchinson F. DNA double-strand breaks and alkali-labile bonds produced by bleomycin. Nucleic Acids Research. 4: 3573-80. PMID 73164 DOI: 10.1093/Nar/4.10.3573 |
0.715 |
|
| 1976 |
Povirk LF, Painter RB. The effect of 313 nanometer light on initiation of replicons in mammalian cell DNA containing bromodeoxyuridine Bba Section Nucleic Acids and Protein Synthesis. 432: 267-272. PMID 1268255 DOI: 10.1016/0005-2787(76)90135-0 |
0.711 |
|
| 1976 |
Povirk LF, Painter RB. Rate of DNA chain elongation in ultraviolet light irradiated mammalian cells as estimated by a bromodeoxyuridine photolysis method Biophysical Journal. 16: 883-889. PMID 938728 |
0.653 |
|
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