| Year |
Citation |
Score |
| 2020 |
Maffioli E, Jiang Z, Nonnis S, Negri A, Romeo V, Lietz CB, Hook V, Ristagno G, Baselli G, Kistler EB, Aletti F, O'Donoghue AJ, Tedeschi G. High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma. Molecules (Basel, Switzerland). 25. PMID 32899982 DOI: 10.3390/Molecules25184071 |
0.334 |
|
| 2020 |
Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140428. PMID 32305689 DOI: 10.1016/J.Bbapap.2020.140428 |
0.322 |
|
| 2020 |
Podvin S, Jones A, Liu Q, Aulston B, Ransom LS, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman R, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-Induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Molecular & Cellular Proteomics : McP. PMID 32295833 DOI: 10.1074/Mcp.Ra120.002079 |
0.348 |
|
| 2020 |
Boutte A, Hook V, Thangavelu B, Sarkis G, Abbatiello B, Hook G, Jacobsen JS, Robertson CS, Gilsdorf J, Yang Z, Wang KKW, Shear DA. Penetrating Traumatic Brain Injury Triggers Subacute Dysregulation of Cathepsin B Protein Levels Independently of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid. Journal of Neurotrauma. PMID 31973644 DOI: 10.1089/Neu.2019.6537 |
0.311 |
|
| 2019 |
Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook VYH, Gerwick WH. Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain. Journal of Medicinal Chemistry. PMID 31539239 DOI: 10.1021/Acs.Jmedchem.9B00294 |
0.321 |
|
| 2019 |
Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki B, El-Sakkary N, Hook VYH, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. The proteasome as a drug target in the metazoan pathogen, . Acs Infectious Diseases. PMID 31355632 DOI: 10.1021/Acsinfecdis.9B00237 |
0.344 |
|
| 2018 |
Podvin S, Wojnicz A, Hook V. Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon. 4: e00673. PMID 29998195 DOI: 10.1016/J.Heliyon.2018.E00673 |
0.342 |
|
| 2018 |
Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O. Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 29667161 DOI: 10.1007/S13361-018-1914-1 |
0.423 |
|
| 2018 |
Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. Journal of the American Society For Mass Spectrometry. PMID 29556927 DOI: 10.1007/S13361-018-1915-0 |
0.382 |
|
| 2015 |
Hook V, Bandeira N. Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems. Journal of the American Society For Mass Spectrometry. PMID 26483184 DOI: 10.1007/S13361-015-1251-6 |
0.343 |
|
| 2015 |
Hook V, Podvin S, Bundey R, Toneff T, Ziegler M. Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Molecular and Cellular Neurosciences. PMID 26092702 DOI: 10.1016/J.Mcn.2015.06.008 |
0.301 |
|
| 2014 |
Cynis H, Funkelstein L, Toneff T, Mosier C, Ziegler M, Koch B, Demuth HU, Hook V. Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion. Neuro-Degenerative Diseases. 14: 85-97. PMID 24943989 DOI: 10.1159/000358430 |
0.385 |
|
| 2014 |
Hook G, Yu J, Toneff T, Kindy M, Hook V. Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. Journal of Alzheimer's Disease : Jad. 41: 129-49. PMID 24595198 DOI: 10.3233/Jad-131370 |
0.383 |
|
| 2014 |
Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick WH. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. Journal of Natural Products. 77: 92-9. PMID 24364476 DOI: 10.1021/Np400727R |
0.339 |
|
| 2014 |
Hook G, Yu J, Kindy MS, Hook V. P1-396: CYSTEINE PROTEASE INHIBITOR, E64D, OF CATHEPSIN B REDUCES PGLU-ABETA AND ABETA, AND IMPROVES MEMORY DEFICITS IN THE APPLON MOUSE MODEL OF AD Alzheimer's & Dementia. 10: P459-P459. DOI: 10.1016/J.Jalz.2014.05.638 |
0.348 |
|
| 2013 |
Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 46: 126-35. PMID 23747840 DOI: 10.1016/J.Peptides.2013.04.020 |
0.425 |
|
| 2013 |
Hook V, Yu J, Hook G, Kindy M. O1-08-02: Cathepsin B produces brain pyro-glu-beta-amyloid in a transgenic Alzheimer's disease mouse model Alzheimer's & Dementia. 9: P143-P143. DOI: 10.1016/J.Jalz.2013.04.093 |
0.312 |
|
| 2012 |
Bark SJ, Wegrzyn J, Taupenot L, Ziegler M, O'Connor DT, Ma Q, Smoot M, Ideker T, Hook V. The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases. Plos One. 7: e41134. PMID 22916103 DOI: 10.1371/Journal.Pone.0041134 |
0.362 |
|
| 2012 |
Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters. Journal of Neurochemistry. 122: 512-22. PMID 22582844 DOI: 10.1111/J.1471-4159.2012.07788.X |
0.411 |
|
| 2012 |
Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. The Journal of Biological Chemistry. 287: 15232-41. PMID 22393040 DOI: 10.1074/Jbc.M111.310607 |
0.376 |
|
| 2012 |
Kindy MS, Yu J, Zhu H, El-Amouri SS, Hook V, Hook GR. Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence. Journal of Alzheimer's Disease : Jad. 29: 827-40. PMID 22337825 DOI: 10.3233/Jad-2012-111604 |
0.3 |
|
| 2012 |
Lu WD, Liu T, Li S, Woods VL, Hook V. The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Science : a Publication of the Protein Society. 21: 178-87. PMID 22102294 DOI: 10.1002/Pro.2000 |
0.387 |
|
| 2012 |
Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochimica Et Biophysica Acta. 1824: 89-104. PMID 21925292 DOI: 10.1016/J.Bbapap.2011.08.015 |
0.473 |
|
| 2012 |
Hook V, Toneff T, Funkelstein L. Beta-amyloid peptides undergo activity-dependent secretion with neurotransmitters Alzheimers & Dementia. 8: 241. DOI: 10.1016/J.Jalz.2012.05.640 |
0.364 |
|
| 2012 |
Hook G, Yu J, Zhu H, El-Amouri S, Hook V, Kindy M. P2-359: Cathepsin B gene deletion or inhibition improves memory deficits in a mouse model of Alzheimer's disease expressing APP with the wild-type beta-secretase site Alzheimer's & Dementia. 8: P386-P387. DOI: 10.1016/J.Jalz.2012.05.1069 |
0.308 |
|
| 2011 |
Kim Y, Bark S, Hook V, Bandeira N. NeuroPedia: neuropeptide database and spectral library. Bioinformatics (Oxford, England). 27: 2772-3. PMID 21821666 DOI: 10.1093/Bioinformatics/Btr445 |
0.329 |
|
| 2011 |
Funkelstein L, Hook V. The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression. Methods in Molecular Biology (Clifton, N.J.). 768: 107-25. PMID 21805239 DOI: 10.1007/978-1-61779-204-5_5 |
0.393 |
|
| 2011 |
Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. Journal of Alzheimer's Disease : Jad. 26: 387-408. PMID 21613740 DOI: 10.3233/Jad-2011-110101 |
0.368 |
|
| 2011 |
Pham VL, Gouzy-Darmon C, Pernier J, Hanquez C, Hook V, Beinfeld MC, Nicolas P, Etchebest C, Foulon T, Cadel S. Mutation in the substrate-binding site of aminopeptidase B confers new enzymatic properties. Biochimie. 93: 730-41. PMID 21237246 DOI: 10.1016/J.Biochi.2010.12.015 |
0.306 |
|
| 2010 |
Funkelstein L, Beinfeld M, Minokadeh A, Zadina J, Hook V. Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides. Neuropeptides. 44: 457-66. PMID 21047684 DOI: 10.1016/J.Npep.2010.08.003 |
0.39 |
|
| 2010 |
Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication. The Aaps Journal. 12: 635-45. PMID 20734175 DOI: 10.1208/S12248-010-9223-Z |
0.546 |
|
| 2010 |
Gupta N, Bark SJ, Lu WD, Taupenot L, O'Connor DT, Pevzner P, Hook V. Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing. Journal of Proteome Research. 9: 5065-75. PMID 20704348 DOI: 10.1021/Pr100358B |
0.561 |
|
| 2010 |
Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. Journal of Proteome Research. 9: 5002-24. PMID 20695487 DOI: 10.1021/Pr1003104 |
0.35 |
|
| 2010 |
Hook V, Hook G, Kindy M. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biological Chemistry. 391: 861-72. PMID 20536395 DOI: 10.1515/Bc.2010.110 |
0.349 |
|
| 2010 |
Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE, Bark S, Dorrestein PC. Expansion of the mycobacterial "PUPylome". Molecular Biosystems. 6: 376-85. PMID 20094657 DOI: 10.1039/B916104J |
0.327 |
|
| 2010 |
Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Molecular and Cellular Neurosciences. 43: 98-107. PMID 19837164 DOI: 10.1016/J.Mcn.2009.10.001 |
0.348 |
|
| 2009 |
Lortie M, Bark S, Blantz R, Hook V. Detecting low-abundance vasoactive peptides in plasma: progress toward absolute quantitation using nano liquid chromatography-mass spectrometry. Analytical Biochemistry. 394: 164-70. PMID 19615967 DOI: 10.1016/J.Ab.2009.07.021 |
0.384 |
|
| 2009 |
Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 30: 1882-91. PMID 19589362 DOI: 10.1016/J.Peptides.2009.06.030 |
0.386 |
|
| 2009 |
Lee JC, Hook V. Proteolytic fragments of chromogranins A and B represent major soluble components of chromaffin granules, illustrated by two-dimensional proteomics with NH(2)-terminal Edman peptide sequencing and MALDI-TOF MS. Biochemistry. 48: 5254-62. PMID 19405523 DOI: 10.1021/Bi9002953 |
0.43 |
|
| 2009 |
Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 35: 429-37. PMID 19343278 DOI: 10.1007/s12020-009-9163-5 |
0.318 |
|
| 2009 |
Bark SJ, Lu WD, Hook V. Linear and accurate quantitation of proenkephalin-derived peptides by isotopic labeling with internal standards and mass spectrometry. Analytical Biochemistry. 389: 18-26. PMID 19289094 DOI: 10.1016/J.Ab.2009.03.010 |
0.376 |
|
| 2009 |
Lu WD, Asmus K, Hwang SR, Li S, Woods VL, Hook V. Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry. Biochemistry. 48: 1604-12. PMID 19173595 DOI: 10.1021/Bi801888J |
0.329 |
|
| 2009 |
Hwang SR, Bundey R, Toneff T, Hook V. Endopin serpin protease inhibitors localize with neuropeptides in secretory vesicles and neuroendocrine tissues. Neuroendocrinology. 89: 210-6. PMID 18840998 DOI: 10.1159/000162916 |
0.31 |
|
| 2008 |
Hook V, Schechter I, Demuth HU, Hook G. Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biological Chemistry. 389: 993-1006. PMID 18979625 DOI: 10.1515/Bc.2008.124 |
0.386 |
|
| 2008 |
Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. The Journal of Biological Chemistry. 283: 35652-9. PMID 18849346 DOI: 10.1074/Jbc.M709010200 |
0.388 |
|
| 2008 |
Hook V, Toneff T, Baylon S, Sei C. Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells. Neuropeptides. 42: 503-11. PMID 18619673 DOI: 10.1016/J.Npep.2008.05.001 |
0.345 |
|
| 2008 |
Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. Journal of Neurochemistry. 106: 384-91. PMID 18410501 DOI: 10.1111/J.1471-4159.2008.05408.X |
0.41 |
|
| 2008 |
Hook V, Funkelstein L, Lu D, Bark S, Wegrzyn J, Hwang SR. Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annual Review of Pharmacology and Toxicology. 48: 393-423. PMID 18184105 DOI: 10.1146/Annurev.Pharmtox.48.113006.094812 |
0.43 |
|
| 2007 |
Wegrzyn J, Lee J, Neveu JM, Lane WS, Hook V. Proteomics of neuroendocrine secretory vesicles reveal distinct functional systems for biosynthesis and exocytosis of peptide hormones and neurotransmitters. Journal of Proteome Research. 6: 1652-65. PMID 17408250 DOI: 10.1021/Pr060503P |
0.406 |
|
| 2007 |
Hook V, Kindy M, Hook G. Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease. Biological Chemistry. 388: 247-52. PMID 17261088 DOI: 10.1515/Bc.2007.027 |
0.364 |
|
| 2007 |
Hwang SR, Garza C, Mosier C, Toneff T, Wunderlich E, Goldsmith P, Hook V. Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. The Journal of Biological Chemistry. 282: 9556-63. PMID 17244622 DOI: 10.1074/Jbc.M605510200 |
0.416 |
|
| 2007 |
Hwang SR, O'Neill A, Bark S, Foulon T, Hook V. Secretory vesicle aminopeptidase B related to neuropeptide processing: molecular identification and subcellular localization to enkephalin- and NPY-containing chromaffin granules. Journal of Neurochemistry. 100: 1340-50. PMID 17241125 DOI: 10.1111/J.1471-4159.2006.04325.X |
0.389 |
|
| 2006 |
Hook VY. Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biological Chemistry. 387: 1429-39. PMID 17081116 DOI: 10.1515/BC.2006.179 |
0.355 |
|
| 2006 |
Hook VY. Protease pathways in peptide neurotransmission and neurodegenerative diseases. Cellular and Molecular Neurobiology. 26: 449-69. PMID 16724274 DOI: 10.1007/s10571-006-9047-7 |
0.331 |
|
| 2006 |
Hook VY. Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 20: 105-19. PMID 16626168 DOI: 10.2165/00063030-200620020-00005 |
0.32 |
|
| 2005 |
Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biological Chemistry. 386: 931-40. PMID 16164418 DOI: 10.1515/Bc.2005.108 |
0.351 |
|
| 2004 |
Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biological Chemistry. 385: 473-80. PMID 15255178 DOI: 10.1515/Bc.2004.055 |
0.427 |
|
| 2003 |
Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, ... ... Hook V, et al. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America. 100: 9590-5. PMID 12869695 DOI: 10.1073/Pnas.1531542100 |
0.446 |
|
| 2003 |
Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 42: 6938-46. PMID 12795588 DOI: 10.1021/Bi0300433 |
0.306 |
|
| 2002 |
Hook V, Metz-Boutigue MH. Protein trafficking to chromaffin granules and proteolytic processing within regulated secretory vesicles of neuroendocrine chromaffin cells. Annals of the New York Academy of Sciences. 971: 397-405. PMID 12438158 DOI: 10.1111/J.1749-6632.2002.Tb04502.X |
0.399 |
|
| 2000 |
Taylor CV, Taupenot L, Mahata SK, Mahata M, Wu H, Yasothornsrikul S, Toneff T, Caporale C, Jiang Q, Parmer RJ, Hook VY, O'Connor DT. Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules. The Journal of Biological Chemistry. 275: 22905-15. PMID 10781584 DOI: 10.1074/Jbc.M001232200 |
0.301 |
|
| 1999 |
Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. The Journal of Biological Chemistry. 274: 3165-72. PMID 9915856 DOI: 10.1074/jbc.274.5.3165 |
0.317 |
|
| 1994 |
Azaryan AV, Hook VY. Distinct properties of prohormone thiol protease (PTP) compared to cathepsins B, L, and H: evidence for PTP as a novel cysteine protease. Archives of Biochemistry and Biophysics. 314: 171-7. PMID 7944391 DOI: 10.1006/abbi.1994.1426 |
0.308 |
|
| 1993 |
Hook VY, Purviance RT, Azaryan AV, Hubbard G, Krieger TJ. Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing. The Journal of Biological Chemistry. 268: 20570-7. PMID 8376411 |
0.334 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2013 |
Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 47: 109-15. PMID 23290538 DOI: 10.1016/J.Npep.2012.10.006 |
0.3 |
|
| 2020 |
Jiang M, Meng J, Zeng F, Qing H, Hook G, Hook V, Wu Z, Ni J. Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling. Journal of Neurochemistry. PMID 32330298 DOI: 10.1111/Jnc.15032 |
0.298 |
|
| 2002 |
Toneff T, Mende-Mueller L, Wu Y, Hwang SR, Bundey R, Thompson LM, Chesselet MF, Hook V. Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain. Journal of Neurochemistry. 82: 84-92. PMID 12091468 DOI: 10.1046/J.1471-4159.2002.00940.X |
0.298 |
|
| 2022 |
Yoon MC, Ames J, Mosier C, Jiang Z, Podvin S, O'Donoghue AJ, Hook V. Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases. Acs Chemical Neuroscience. PMID 34986304 DOI: 10.1021/acschemneuro.1c00653 |
0.298 |
|
| 2018 |
Hsu A, Podvin S, Hook V. Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development. Journal of Molecular Neuroscience : Mn. PMID 30008074 DOI: 10.1007/S12031-018-1110-6 |
0.297 |
|
| 1999 |
Hwang SR, Steineckert B, Yasothornsrikul S, Sei CA, Toneff T, Rattan J, Hook VY. Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1. The Journal of Biological Chemistry. 274: 34164-73. PMID 10567388 DOI: 10.1074/jbc.274.48.34164 |
0.296 |
|
| 2008 |
Hwang SR, Hook V. Zinc regulation of aminopeptidase B involved in neuropeptide production. Febs Letters. 582: 2527-31. PMID 18571504 DOI: 10.1016/J.Febslet.2008.06.017 |
0.295 |
|
| 1994 |
Azaryan AV, Hook VY. Unique cleavage specificity of 'prohormone thiol protease' related to proenkephalin processing. Febs Letters. 341: 197-202. PMID 8137939 DOI: 10.1016/0014-5793(94)80456-7 |
0.295 |
|
| 2010 |
Chakrabarti L, Zahra R, Jackson SM, Kazemi-Esfarjani P, Sopher BL, Mason AG, Toneff T, Ryu S, Shaffer S, Kansy JW, Eng J, Merrihew G, MacCoss MJ, Murphy A, Goodlett DR, ... Hook V, et al. Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron. 66: 835-47. PMID 20620870 DOI: 10.1016/J.Neuron.2010.05.024 |
0.293 |
|
| 2008 |
Hook G, Kindy M, Hook V. P2-300: Inhibitors of cathepsin B for Alzheimer's disease therapeutics Alzheimer's & Dementia. 4: T460-T460. DOI: 10.1016/J.Jalz.2008.05.1376 |
0.293 |
|
| 2004 |
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death and Differentiation. 11: 424-38. PMID 14713958 DOI: 10.1038/Sj.Cdd.4401358 |
0.291 |
|
| 2011 |
Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel PA. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cellular Signalling. 23: 1611-6. PMID 21620962 DOI: 10.1016/J.Cellsig.2011.05.014 |
0.29 |
|
| 2015 |
Hook G, Jacobsen JS, Grabstein K, Kindy M, Hook V. Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Frontiers in Neurology. 6: 178. PMID 26388830 DOI: 10.3389/Fneur.2015.00178 |
0.289 |
|
| 2001 |
Hook VY, Burton D, Yasothornsrikul S, Hastings RH, Deftos LJ. Proteolysis of ProPTHrP(1-141) by "prohormone thiol protease" at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells. Biochemical and Biophysical Research Communications. 285: 932-8. PMID 11467841 DOI: 10.1006/bbrc.2001.5249 |
0.289 |
|
| 2024 |
Podvin S, Jones J, Kang A, Goodman R, Reed P, Lietz CB, Then J, Lee KC, Eyler LT, Jeste DV, Gage FH, Hook V. Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. Molecular Psychiatry. PMID 38302561 DOI: 10.1038/s41380-024-02422-x |
0.289 |
|
| 1990 |
Schwarzenbrunner U, Schmidle T, Obendorf D, Scherman D, Hook V, Fischer-Colbrie R, Winkler H. Sympathetic axons and nerve terminals: the protein composition of small and large dense-core and of a third type of vesicles. Neuroscience. 37: 819-27. PMID 2123305 DOI: 10.1016/0306-4522(90)90111-G |
0.287 |
|
| 2019 |
Hook V, Kind T, Podvin S, Palazoglu M, Tran C, Toneff T, Samra S, Lietz C, Fiehn O. Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium. Acs Chemical Neuroscience. PMID 30698015 DOI: 10.1021/Acschemneuro.8B00432 |
0.286 |
|
| 2006 |
Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes, Obesity & Metabolism. 8: 621-33. PMID 17026486 DOI: 10.1111/J.1463-1326.2006.00575.X |
0.285 |
|
| 2016 |
Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-SchÖnbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, et al. Identification of Novel Loci Affecting Circulating Chromogranins and Related Peptides. Human Molecular Genetics. PMID 28011710 DOI: 10.1093/Hmg/Ddw380 |
0.284 |
|
| 2021 |
Jiang Z, Lietz CB, Podvin S, Yoon MC, Toneff T, Hook V, O'Donoghue AJ. Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. Acs Chemical Neuroscience. PMID 34153188 DOI: 10.1021/acschemneuro.1c00133 |
0.283 |
|
| 2021 |
Jiang Z, Lietz CB, Podvin S, Yoon MC, Toneff T, Hook V, O'Donoghue AJ. Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. Acs Chemical Neuroscience. PMID 34153188 DOI: 10.1021/acschemneuro.1c00133 |
0.283 |
|
| 2013 |
Hook G, Yu J, Sipes N, Pierschbacher M, Hook V, Kindy M. E64d treatment improves outcomes in animal models of traumatic brain injury, ischemia and Alzheimer's disease through inhibiting cathepsin B Alzheimers & Dementia. 9: 703. DOI: 10.1016/J.Jalz.2013.04.392 |
0.281 |
|
| 1986 |
Laslop A, Fischer-Colbrie R, Hook V, Obendorf D, Winkler H. Identification of two glycoproteins of chromaffin granules as the carboxypeptidase H. Neuroscience Letters. 72: 300-4. PMID 3103029 DOI: 10.1016/0304-3940(86)90530-6 |
0.279 |
|
| 1983 |
Reisine TD, Heisler S, Hook VY, Axelrod J. Activation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells increases cyclic adenosine 3':5'-monophosphate synthesis and adrenocorticotropin release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 3: 725-32. PMID 6300355 DOI: 10.1523/Jneurosci.03-04-00725.1983 |
0.277 |
|
| 2007 |
Bark SJ, Hook V. The future of proteomic analysis in biological systems and molecular medicine. Molecular Biosystems. 3: 14-7. PMID 17216050 DOI: 10.1039/B611446F |
0.275 |
|
| 2006 |
Hwang SR, Stoka V, Turk V, Hook V. Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity. Biochemical and Biophysical Research Communications. 340: 1238-43. PMID 16414353 DOI: 10.1016/J.Bbrc.2005.12.130 |
0.275 |
|
| 2014 |
Hook V, Yu J, Toneff T, Kindy MS, Hook G. O1-10-05: CATHEPSIN B KNOCKOUT REDUCES PGLU-ABETA AND ABETA, AND IMPROVES MEMORY DEFICITS, IN THE APPLON MOUSE MODEL OF AD Alzheimer's & Dementia. 10: P150-P150. DOI: 10.1016/J.Jalz.2014.04.114 |
0.275 |
|
| 2014 |
Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 3: 531-8. PMID 25358781 DOI: 10.1016/J.Stemcr.2014.08.001 |
0.272 |
|
| 2002 |
Hook VY, Hwang SR. Novel secretory vesicle serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities. Biological Chemistry. 383: 1067-74. PMID 12437089 DOI: 10.1515/BC.2002.115 |
0.272 |
|
| 2002 |
Hook VY, Yasothornsrikul S, Hwang SR. Novel chromaffin granule serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities. Annals of the New York Academy of Sciences. 971: 426-44. PMID 12438161 |
0.271 |
|
| 1987 |
Hook VY, LaGamma EF. Product inhibition of carboxypeptidase H. The Journal of Biological Chemistry. 262: 12583-8. PMID 2887569 |
0.271 |
|
| 2022 |
Podvin S, Jiang Z, Boyarko B, Rossitto LA, O'Donoghue A, Rissman RA, Hook V. Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. Acs Chemical Neuroscience. PMID 35758417 DOI: 10.1021/acschemneuro.2c00222 |
0.268 |
|
| 1995 |
Schiller MR, Mende-Mueller L, Moran K, Meng M, Miller KW, Hook VY. "Prohormone thiol protease" (PTP) processing of recombinant proenkephalin. Biochemistry. 34: 7988-95. PMID 7794912 DOI: 10.1021/BI00025A004 |
0.267 |
|
| 2001 |
Hook V. Differential processing of tau in corticobasal degeneration (CBD) and supranuclear palsy (PSP): Proteolysis as a central mechanism in neurodegenerative diseases Neuroreport. 12: A27. DOI: 10.1097/00001756-200104170-00001 |
0.266 |
|
| 2018 |
Podvin S, Reardon HT, Yin K, Mosier C, Hook V. Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. Journal of Neurology. PMID 29956026 DOI: 10.1007/S00415-018-8940-6 |
0.264 |
|
| 1988 |
Hook VY. Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing. Cellular and Molecular Neurobiology. 8: 49-55. PMID 3135937 DOI: 10.1007/BF00712911 |
0.264 |
|
| 1988 |
Hook VY, Affolter HU. Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones. Febs Letters. 238: 338-42. PMID 2458970 DOI: 10.1016/0014-5793(88)80508-8 |
0.264 |
|
| 1999 |
Hook VY, Noctor S, Sei CA, Toneff T, Yasothornsrikul S, Kang YH. Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells. Endocrinology. 140: 3744-54. PMID 10433235 DOI: 10.1210/endo.140.8.6926 |
0.262 |
|
| 1995 |
Azaryan AV, Schiller M, Mende-Mueller L, Hook VY. Characteristics of the chromaffin granule aspartic proteinase involved in proenkephalin processing. Journal of Neurochemistry. 65: 1771-9. PMID 7561875 |
0.261 |
|
| 1991 |
Krieger TJ, Hook VY. Purification and characterization of a novel thiol protease involved in processing the enkephalin precursor. The Journal of Biological Chemistry. 266: 8376-83. PMID 2022653 |
0.261 |
|
| 1997 |
Hook VY, Moran K, Kannan R, Kohn A, Lively MO, Azaryan A, Schiller M, Miller K. High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing. Protein Expression and Purification. 10: 80-8. PMID 9179294 DOI: 10.1006/Prep.1996.0715 |
0.26 |
|
| 1996 |
Hook VY, Schiller MR, Nguyen C, Yasothornsrikul S. Production of radiolabeled neuropeptide precursors by in vitro transcription and translation. Peptide Research. 9: 183-7. PMID 8914165 |
0.26 |
|
| 1992 |
Krieger TJ, Mende-Mueller L, Hook VY. Prohormone thiol protease and enkephalin precursor processing: cleavage at dibasic and monobasic sites. Journal of Neurochemistry. 59: 26-31. PMID 1613503 DOI: 10.1016/B978-0-12-382219-2.00557-3 |
0.255 |
|
| 2008 |
Wegrzyn JL, Drudge TM, Valafar F, Hook V. Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites. Bmc Bioinformatics. 9: 232. PMID 18466625 DOI: 10.1186/1471-2105-9-232 |
0.255 |
|
| 1994 |
Hook VY, Azaryan AV, Hwang SR, Tezapsidis N. Proteases and the emerging role of protease inhibitors in prohormone processing. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 1269-78. PMID 8001739 |
0.253 |
|
| 2016 |
Petras D, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook VY, Garg N, Hoffner N, Jiang Y, Kapono CA, et al. Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Analytical Chemistry. PMID 27732780 DOI: 10.1021/Acs.Analchem.6B03456 |
0.252 |
|
| 1997 |
Sokol RJ, Booker DJ, Stamps R, Booth JR, Hook V. IgA red cell autoantibodies and autoimmune hemolysis. Transfusion. 37: 175-81. PMID 9051092 DOI: 10.1046/J.1537-2995.1997.37297203520.X |
0.25 |
|
| 2002 |
Hook VY, Toneff T, Aaron W, Yasothornsrikul S, Bundey R, Reisine T. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles. Journal of Neurochemistry. 81: 237-56. PMID 12064471 DOI: 10.1046/j.1471-4159.2002.00794.x |
0.249 |
|
| 2007 |
Hook G, Hook VY, Kindy M. Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics. Biological Chemistry. 388: 979-83. PMID 17696783 DOI: 10.1515/Bc.2007.117 |
0.248 |
|
| 1996 |
Schiller MR, Kohn AB, Mende-Muelller LM, Miller K, Hook VY. Expression of recombinant pro-neuropeptide Y, proopiomelanocortin, and proenkephalin: relative processing by 'prohormone thiol protease' (PTP). Febs Letters. 382: 6-10. PMID 8612764 DOI: 10.1016/0014-5793(96)00083-X |
0.244 |
|
| 2016 |
Podvin S, Yaksh T, Hook V. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annual Review of Pharmacology and Toxicology. 56: 511-33. PMID 26738478 DOI: 10.1146/Annurev-Pharmtox-010715-103042 |
0.24 |
|
| 1985 |
Hook VY, Mezey E, Fricker LD, Pruss RM, Siegel RE, Brownstein MJ. Immunochemical characterization of carboxypeptidase B-like peptide-hormone-processing enzyme. Proceedings of the National Academy of Sciences of the United States of America. 82: 4745-9. PMID 3927290 DOI: 10.1073/Pnas.82.14.4745 |
0.238 |
|
| 2018 |
Xu JH, Jiang Z, Solania A, Chatterjee S, Suzuki B, Lietz CB, Hook VYH, O'Donoghue AJ, Wolan DW. A Commensal Dipeptidyl Aminopeptidase with Specificity for N-terminal Glycine Degrades Human-produced Antimicrobial Peptides In Vitro. Acs Chemical Biology. PMID 30085657 DOI: 10.1021/Acschembio.8B00420 |
0.238 |
|
| 1998 |
Yasothornsrikul S, Toneff T, Hwang SR, Hook VY. Arginine and lysine aminopeptidase activities in chromaffin granules of bovine adrenal medulla: relevance to prohormone processing. Journal of Neurochemistry. 70: 153-63. PMID 9422358 |
0.237 |
|
| 1995 |
Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook VY, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. Journal of Neurochemistry. 64: 2140-6. PMID 7722498 DOI: 10.1046/J.1471-4159.1995.64052140.X |
0.233 |
|
| 1992 |
Azaryan AV, Hook VY. Kex2-like proteolytic activity in adrenal medullary chromaffin granules. Biochemical and Biophysical Research Communications. 185: 398-403. PMID 1599477 DOI: 10.1016/S0006-291X(05)80999-4 |
0.232 |
|
| 1995 |
Tezapsidis N, Noctor S, Kannan R, Krieger TJ, Mende-Mueller L, Hook VY. Stimulation of "prohormone thiol protease" (PTP) and [Met]enkephalin by forskolin. Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP. The Journal of Biological Chemistry. 270: 13285-90. PMID 7768928 DOI: 10.1074/Jbc.270.22.13285 |
0.231 |
|
| 1984 |
Hook VY, Loh YP. Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary. Proceedings of the National Academy of Sciences of the United States of America. 81: 2776-80. PMID 6326144 |
0.228 |
|
| 2003 |
Hook VY, Reisine TD. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. Journal of Neuroscience Research. 74: 393-405. PMID 14598316 DOI: 10.1002/jnr.10784 |
0.228 |
|
| 2001 |
Deftos LJ, Burton D, Hastings RH, Terkeltaub R, Hook VY. Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues. Endocrine. 15: 217-24. PMID 11720250 DOI: 10.1385/Endo:15:2:217 |
0.227 |
|
| 2009 |
Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochemical and Biophysical Research Communications. 386: 284-8. PMID 19501042 DOI: 10.1016/J.Bbrc.2009.05.131 |
0.226 |
|
| 1990 |
Hook VY, Hegerle D, Affolter HU. Cleavage of recombinant enkephalin precursor by endoproteolytic activity in bovine chromaffin granules. Biochemical and Biophysical Research Communications. 167: 722-30. PMID 2182020 DOI: 10.1016/0006-291X(90)92085-E |
0.226 |
|
| 1990 |
Hook VY. Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme. Life Sciences. 47: 1135-9. PMID 2122147 DOI: 10.1016/0024-3205(90)90173-O |
0.225 |
|
| 2014 |
Suhy A, Hartmann K, Newman L, Papp A, Toneff T, Hook V, Sadee W. Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein. Biochemical and Biophysical Research Communications. 443: 1270-4. PMID 24393849 DOI: 10.1016/J.Bbrc.2013.12.127 |
0.224 |
|
| 2002 |
Hwang SR, Steineckert B, Toneff T, Bundey R, Logvinova AV, Goldsmith P, Hook VY. The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells. Biochemistry. 41: 10397-405. PMID 12173926 DOI: 10.1021/bi020088o |
0.223 |
|
| 2014 |
Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook VY, Mahata SK, Vaingankar S, O'Connor DT. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. Journal of Neurochemistry. 129: 48-59. PMID 24266713 DOI: 10.1111/jnc.12527 |
0.219 |
|
| 1999 |
Yasothornsrikul S, Aaron W, Toneff T, Hook VY. Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles. Biochemistry. 38: 7421-30. PMID 10360939 DOI: 10.1021/bi990239w |
0.217 |
|
| 2008 |
Hook VY, Kindy M, Hook G. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. The Journal of Biological Chemistry. 283: 7745-53. PMID 18184658 DOI: 10.1074/Jbc.M708362200 |
0.215 |
|
| 2007 |
Bark SJ, Hook V. Differential recovery of peptides from sample tubes and the reproducibility of quantitative proteomic data. Journal of Proteome Research. 6: 4511-6. PMID 17850064 DOI: 10.1021/pr070294o |
0.215 |
|
| 2022 |
Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V. Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders. Pharmacological Reviews. 74: 600-629. PMID 35710131 DOI: 10.1124/pharmrev.121.000527 |
0.214 |
|
| 2021 |
Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. Acs Omega. 6: 13033-13056. PMID 34056454 DOI: 10.1021/acsomega.1c00660 |
0.213 |
|
| 1998 |
Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. Journal of Neurochemistry. 71: 2365-72. PMID 9832134 DOI: 10.1046/J.1471-4159.1998.71062365.X |
0.213 |
|
| 2005 |
Hook VY, Toneff T, Hook G, Reisine T. [P‐209]: Beta‐secretases for production of beta‐amyloid in the major regulated secretory pathway are identified as cathepsins B and L: Implications for cysteine proteases as drug targets for AD Alzheimer's & Dementia. 1. DOI: 10.1016/j.jalz.2005.06.267 |
0.212 |
|
| 2003 |
Miller R, Toneff T, Vishnuvardhan D, Beinfeld M, Hook VY. Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice. Neuropeptides. 37: 140-8. PMID 12860111 DOI: 10.1016/S0143-4179(03)00027-1 |
0.212 |
|
| 1987 |
Hook VY, Liston D. Distribution of enkephalin-containing peptides within bovine chromaffin granules. Neuropeptides. 9: 263-7. PMID 3302749 DOI: 10.1016/0143-4179(87)90001-1 |
0.21 |
|
| 1984 |
Hook VY, Eiden LE. Two peptidases that convert 125I-Lys-Arg-(Met)enkephalin and 125I-(Met)enkephalin-Arg6, respectively, to 125I-(Met)enkephalin in bovine adrenal medullary chromaffin granules. Febs Letters. 172: 212-8. PMID 6378657 DOI: 10.1016/0014-5793(84)81128-X |
0.207 |
|
| 1999 |
Hook VY, Tezapsidis N, Hwang SR, Sei C, Byrne M, Yasothornsrikul S. Alpha1-antichymotrypsin-like proteins I and II purified from bovine adrenal medulla are enriched in chromaffin granules and inhibit the proenkephalin processing enzyme "prohormone thiol protease". Journal of Neurochemistry. 73: 59-69. PMID 10386955 DOI: 10.1046/j.1471-4159.1999.0730059.x |
0.207 |
|
| 1992 |
Krieger TJ, Hook VY. Purification and characterization of a cathepsin D protease from bovine chromaffin granules. Biochemistry. 31: 4223-31. PMID 1567870 |
0.206 |
|
| 1996 |
Hook VY, Schiller MR, Azaryan AV, Tezapsidis N. Proenkephalin-processing enzymes in chromaffin granules: model for neuropeptide biosynthesis. Annals of the New York Academy of Sciences. 780: 121-33. PMID 8602725 DOI: 10.1111/j.1749-6632.1996.tb15116.x |
0.2 |
|
| 2023 |
Hook G, Kindy M, Hook V. Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition. Journal of Alzheimer's Disease : Jad. PMID 36970896 DOI: 10.3233/JAD-221005 |
0.2 |
|
| 1985 |
Hook VY, Eiden LE, Pruss RM. Selective regulation of carboxypeptidase peptide hormone-processing enzyme during enkephalin biosynthesis in cultured bovine adrenomedullary chromaffin cells. The Journal of Biological Chemistry. 260: 5991-7. PMID 4039723 |
0.199 |
|
| 2000 |
Yasothornsrikul S, Hook VY. Detection of proteolytic activity by fluorescent zymogram in-gel assays. Biotechniques. 28: 1166-8, 1170, 1172-3. PMID 10868282 |
0.199 |
|
| 2008 |
Courel M, Vasquez MS, Hook VY, Mahata SK, Taupenot L. Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains. The Journal of Biological Chemistry. 283: 11807-22. PMID 18299326 DOI: 10.1074/jbc.M709832200 |
0.197 |
|
| 1997 |
Yasothornsrikul S, Hook V. Novel arginine and lysine aminopeptidase activities in neurosecretory vesicles of bovine adrenal medulla: Involvement in prohormone processing Faseb Journal. 11: A1395. |
0.197 |
|
| 1982 |
Heisler S, Reisine TD, Hook VY, Axelrod J. Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 6502-6. PMID 6128732 DOI: 10.1073/Pnas.79.21.6502 |
0.197 |
|
| 2020 |
Ashhurst AS, Tang AH, Fajtová P, Yoon M, Aggarwal A, Stoye A, Larance M, Beretta L, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CK, et al. Potent anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. Biorxiv : the Preprint Server For Biology. PMID 33398273 DOI: 10.1101/2020.12.23.424111 |
0.197 |
|
| 1990 |
Hook VY, Affolter HU, Palkovits M. Carboxypeptidase H in the hypothalamo-neurohypophysial system: evidence for processing and activation of a prohormone-processing enzyme during axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3219-26. PMID 1698942 |
0.196 |
|
| 2005 |
Hwang SR, Garza CZ, Wegrzyn JL, Hook VY. Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2. Biochemical and Biophysical Research Communications. 327: 837-44. PMID 15649421 DOI: 10.1016/j.bbrc.2004.12.053 |
0.196 |
|
| 2021 |
Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, et al. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. Journal of Medicinal Chemistry. PMID 34730959 DOI: 10.1021/acs.jmedchem.1c01494 |
0.195 |
|
| 2021 |
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, ... ... Hook V, et al. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. Acs Chemical Biology. PMID 33787221 DOI: 10.1021/acschembio.0c00875 |
0.194 |
|
| 1995 |
Hwang SR, Kohn AB, Hook VY. Unique reactive site domains of neuroendocrine isoforms of alpha 1-antichymotrypsin from bovine adrenal medulla and pituitary revealed by molecular cloning. Febs Letters. 368: 471-6. PMID 7635201 DOI: 10.1016/0014-5793(95)00709-I |
0.194 |
|
| 1983 |
Heisler S, Hook VY, Axelrod J. Corticotropin releasing factor stimulation of protein carboxylmethylation in mouse pituitary tumor cells. Biochemical Pharmacology. 32: 1295-9. PMID 6303356 DOI: 10.1016/0006-2952(83)90285-X |
0.193 |
|
| 1995 |
Azaryan AV, Krieger TJ, Hook VY. Purification and characteristics of the candidate prohormone processing proteases PC2 and PC1/3 from bovine adrenal medulla chromaffin granules. The Journal of Biological Chemistry. 270: 8201-8. PMID 7713926 DOI: 10.1074/jbc.270.14.8201 |
0.193 |
|
| 2004 |
Hwang SR, Garza CZ, Wegrzyn J, Hook VY. Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B. The Journal of Biological Chemistry. PMID 15316004 DOI: 10.1074/jbc.M409166200 |
0.191 |
|
| 1992 |
Toomim CS, Hook VY. Thiol and aspartyl proteolytic activities in secretory vesicles of bovine pituitary. Biochemical and Biophysical Research Communications. 183: 449-55. PMID 1550554 DOI: 10.1016/0006-291X(92)90502-C |
0.19 |
|
| 1996 |
Hook VY, Schiller MR, Azaryan AV. The processing proteases prohormone thiol protease, PC1/3 and PC2, and 70-kDa aspartic proteinase show preferences among proenkephalin, proneuropeptide Y, and proopiomelanocortin substrates. Archives of Biochemistry and Biophysics. 328: 107-14. PMID 8638918 DOI: 10.1006/abbi.1996.0149 |
0.187 |
|
| 1999 |
Hwang SR, Steineckert B, Kohn A, Palkovits M, Hook VY. Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver. The Journal of Biological Chemistry. 274: 1821-7. PMID 9880565 DOI: 10.1074/jbc.274.3.1821 |
0.187 |
|
| 2003 |
Sei C, Toneff T, Aaron W, Hook VY. Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH. Peptides. 24: 717-25. PMID 12895658 DOI: 10.1016/S0196-9781(03)00126-8 |
0.185 |
|
| 1998 |
Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 37: 1274-82. PMID 9477953 DOI: 10.1021/Bi9714159 |
0.182 |
|
| 1995 |
Azaryan AV, Schiller MR, Hook VY. Chromaffin granule aspartic proteinase processes recombinant proopiomelanocortin (POMC). Biochemical and Biophysical Research Communications. 215: 937-44. PMID 7488064 DOI: 10.1006/bbrc.1995.2554 |
0.182 |
|
| 2000 |
Hwang SR, Steineckert B, Hook VY. Expression and mutagenesis of the novel serpin endopin 2 demonstrates a requirement for cysteine-374 for dithiothreitol-sensitive inhibition of elastase. Biochemistry. 39: 8944-52. PMID 10913307 DOI: 10.1021/bi9929655 |
0.179 |
|
| 2014 |
Hook GR, Yu J, Sipes N, Pierschbacher MD, Hook V, Kindy MS. The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury. Journal of Neurotrauma. 31: 515-29. PMID 24083575 DOI: 10.1089/neu.2013.2944 |
0.177 |
|
| 1990 |
Hook VYH, Krieger TJ. Processing of recombinant enkephalin precursor by proteolytic activity in bovine chromaffin granules New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 374-375. |
0.175 |
|
| 2023 |
Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease. Frontiers in Pharmacology. 14: 1190402. PMID 37601062 DOI: 10.3389/fphar.2023.1190402 |
0.173 |
|
| 2024 |
Almaliti J, Alhindy M, Yoon MC, Hook V, Molinski TF, O'Donoghue AJ, Gerwick WH. Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK. Acs Omega. 9: 3997-4003. PMID 38284081 DOI: 10.1021/acsomega.3c08629 |
0.173 |
|
| 2023 |
Hook V, Podvin S, Mosier C, Boyarko B, Seyffert L, Stringer H, Rissman RA. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular Vesicles and Circulating Nucleic Acids. 4: 588-598. PMID 38125374 DOI: 10.20517/evcna.2023.44 |
0.171 |
|
| 1984 |
Hook VY. Carboxypeptidase B-like activity for the processing of enkephalin precursors in the membrane component of bovine adrenomedullary chromaffin granules. Neuropeptides. 4: 117-26. PMID 6546974 DOI: 10.1016/0143-4179(84)90122-7 |
0.169 |
|
| 1982 |
Reisine T, Heisler S, Hook VY, Axelrod J. Multireceptor-induced release of adrenocorticotropin from anterior pituitary tumor cells. Biochemical and Biophysical Research Communications. 108: 1251-7. PMID 6295371 DOI: 10.1016/0006-291X(82)92134-9 |
0.168 |
|
| 2012 |
Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook VY, O'Connor DT. Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure. Journal of Hypertension. 30: 1961-9. PMID 22871890 DOI: 10.1097/Hjh.0B013E328356B86A |
0.168 |
|
| 2005 |
Hwang SR, Stoka V, Turk V, Hook VY. The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition. Biochemistry. 44: 7757-67. PMID 15909990 DOI: 10.1021/bi050053z |
0.168 |
|
| 2023 |
Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. PMID 37459182 DOI: 10.1021/acs.biochem.3c00139 |
0.167 |
|
| 1994 |
Hwang SR, Kohn AB, Hook VY. Molecular cloning reveals isoforms of bovine alpha 1-antichymotrypsin. Proceedings of the National Academy of Sciences of the United States of America. 91: 9579-83. PMID 7937809 |
0.167 |
|
| 2021 |
Boyarko B, Hook V. Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration. Frontiers in Neuroscience. 15: 702788. PMID 34744602 DOI: 10.3389/fnins.2021.702788 |
0.167 |
|
| 2002 |
Sei C, Toneff T, Aaron W, Hook VY. Regulation of cellular alpha-MSH and beta-endorphin during stimulated secretion from intermediate pituitary cells: involvement of aspartyl and cysteine proteases in the control of cellular levels of alpha-MSH and beta-endorphin. Peptides. 23: 1409-18. PMID 12182941 DOI: 10.1016/S0196-9781(02)00079-7 |
0.16 |
|
| 2003 |
Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld MC, Hook VY. Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. Journal of Neurochemistry. 86: 556-63. PMID 12859669 DOI: 10.1046/j.1471-4159.2003.01856.x |
0.16 |
|
| 2001 |
Mende-Mueller LM, Toneff T, Hwang SR, Chesselet MF, Hook VY. Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1830-7. PMID 11245667 DOI: 10.1523/Jneurosci.21-06-01830.2001 |
0.158 |
|
| 1985 |
Hook VY, Eiden LE. (Met)enkephalin and carboxypeptidase processing enzyme are co-released from chromaffin cells by cholinergic stimulation. Biochemical and Biophysical Research Communications. 128: 563-70. PMID 3994713 DOI: 10.1016/0006-291X(85)90083-X |
0.156 |
|
| 1988 |
Chesselet MF, Hook VY. Carboxypeptidase H-like immunoreactivity in the striatum of cats and monkeys. Regulatory Peptides. 20: 151-9. PMID 2452460 DOI: 10.1016/0167-0115(88)90048-1 |
0.155 |
|
| 1982 |
Hook VY, Heisler S, Axelrod J. Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 6220-4. PMID 6292895 DOI: 10.1073/Pnas.79.20.6220 |
0.151 |
|
| 2021 |
Yoon MC, Solania A, Jiang Z, Christy MP, Podvin S, Mosier C, Lietz CB, Ito G, Gerwick WH, Wolan DW, Hook G, O'Donoghue AJ, Hook V. Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. Acs Chemical Biology. PMID 34416110 DOI: 10.1021/acschembio.1c00138 |
0.151 |
|
| 2021 |
Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, et al. Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Molecular Therapy. Methods & Clinical Development. 21: 434-450. PMID 33981778 DOI: 10.1016/j.omtm.2021.03.021 |
0.147 |
|
| 1995 |
Hwang SR, Kohn AB, Hook VY. Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus. Biochemical and Biophysical Research Communications. 207: 701-7. PMID 7864863 DOI: 10.1006/bbrc.1995.1244 |
0.146 |
|
| 1982 |
Hook VY, Heisler S, Sabol SL, Axelrod J. Corticotropin releasing factor stimulates adrenocorticotropin and beta-endorphin release from AtT-20 mouse pituitary tumor cells. Biochemical and Biophysical Research Communications. 106: 1364-71. PMID 6288045 DOI: 10.1016/0006-291X(82)91264-5 |
0.146 |
|
| 2022 |
Podvin S, Rosenthal SB, Poon W, Wei E, Fisch KM, Hook V. Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. Journal of Huntington's Disease. PMID 35871359 DOI: 10.3233/JHD-220538 |
0.142 |
|
| 2007 |
O'Connor DT, Mahata SK, Mahata M, Jiang Q, Hook VY, Taupenot L. Primary culture of bovine chromaffin cells. Nature Protocols. 2: 1248-53. PMID 17546020 DOI: 10.1038/nprot.2007.136 |
0.141 |
|
| 1994 |
Hwang SR, Hook VY. Identification of carboxypeptidase H transcripts by antisense RNA. Brain Research. Molecular Brain Research. 25: 135-9. PMID 7984038 DOI: 10.1016/0169-328X(94)90288-7 |
0.141 |
|
| 1980 |
Hook VY, Lee NM, Loh HH. Partial purification of nuclear protein kinase from small dense nuclei of mouse brain and the effect of chronic morphine treatment. Journal of Neurochemistry. 34: 1274-9. PMID 6246205 DOI: 10.1111/J.1471-4159.1980.Tb09971.X |
0.14 |
|
| 1985 |
Hook VY. Differential distribution of carboxypeptidase-processing enzyme activity and immunoreactivity in membrane and soluble components of chromaffin granules. Journal of Neurochemistry. 45: 987-9. PMID 3928813 |
0.136 |
|
| 2015 |
Hwang SR, Garza CZ, Wegrzyn J, Hook VY. Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B. The Journal of Biological Chemistry. 290: 19010. PMID 26232402 DOI: 10.1074/jbc.A115.409166 |
0.136 |
|
| 2023 |
Podvin S, Mosier C, Poon W, Wei E, Rossotto LA, Hook V. Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems. Journal of Huntington's Disease. 12: 315-333. PMID 38108356 DOI: 10.3233/JHD-230577 |
0.135 |
|
| 2002 |
Bundey RA, Toneff T, Pottenger J, Kennedy BP, Ziegler MG, Hook VY. Agonist-stimulated neuropeptide and catecholamine release from bovine adrenal chromaffin cells. Annals of the New York Academy of Sciences. 971: 338-40. PMID 12438146 DOI: 10.1111/J.1749-6632.2002.Tb04490.X |
0.135 |
|
| 2022 |
Yoon MC, Hook V, O'Donoghue AJ. Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range. Biochemistry. PMID 35981509 DOI: 10.1021/acs.biochem.2c00358 |
0.126 |
|
| 1997 |
Hwang SR, Palkovits M, Hook VY. High level expression and characterization of recombinant human hippocampus phenol sulfotransferase: a novel phenol-sulfating form of phenol sulfotransferase. Protein Expression and Purification. 11: 125-34. PMID 9325148 DOI: 10.1006/prep.1997.0782 |
0.123 |
|
| 1997 |
Hook VYH. The novel 'prohormone thiol protease' (PTP) possesses distinct preferences for prohormone substrates Faseb Journal. 11: A1396. |
0.123 |
|
| 1981 |
Hook VY, Stokes KB, Lee NM, Loh HH. Possible nuclear protein kinase regulation of homologous ribonucleic acid polymerases from small dense nuclei of mouse brain during morphine tolerance-dependence. Involvement of cyclic 3',5'-adenosine monophosphate. Biochemical Pharmacology. 30: 2313-8. PMID 6271139 DOI: 10.1016/0006-2952(81)90104-0 |
0.117 |
|
| 1982 |
Heisler S, Hook V, Axelrod J. Corticotropin-releasing factor (CRF) stimulation of cyclic AMP synthesis and adrenocorticotropin (ACTH) secretion in pituitary tumor cells Clinical and Investigative Medicine. 5: 12B. |
0.115 |
|
| 2022 |
Yoon MC, Christy MP, Phan VV, Gerwick WH, Hook G, O'Donoghue AJ, Hook V. Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B. Biochemistry. PMID 35119840 DOI: 10.1021/acs.biochem.1c00684 |
0.115 |
|
| 2010 |
Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, et al. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cellular and Molecular Neurobiology. 30: 1395-400. PMID 21061160 DOI: 10.1007/S10571-010-9600-2 |
0.114 |
|
| 1979 |
Hook VYH, Lee NM, Loh HH. Partial purification of nuclear protein kinases from mouse brain and the effect of chronic morphine treatment Federation Proceedings. 38: No.139. |
0.112 |
|
| 1982 |
Hook VY, Eiden LE, Brownstein MJ. A carboxypeptidase processing enzyme for enkephalin precursors. Nature. 295: 341-2. PMID 7057899 |
0.111 |
|
| 2000 |
Hwang SR, Ng SM, Steineckert B, Seidah NG, Hook VY. Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. Dna and Cell Biology. 19: 409-19. PMID 10945231 DOI: 10.1089/10445490050085906 |
0.109 |
|
| 2019 |
Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, ... ... Hook VYH, et al. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science (New York, N.Y.). 364. PMID 30975860 DOI: 10.1126/Science.Aau8650 |
0.105 |
|
| 2000 |
O'Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. Heredity and the autonomic nervous system in human hypertension. Current Hypertension Reports. 2: 16-22. PMID 10982526 DOI: 10.1007/S11906-000-0053-8 |
0.103 |
|
| 2022 |
Phan VV, Mosier C, Yoon MC, Glukhov E, Caffrey CR, O'Donoghue AJ, Gerwick WH, Hook V. Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions. Acs Omega. 7: 25346-25352. PMID 35910167 DOI: 10.1021/acsomega.2c02287 |
0.098 |
|
| 2007 |
Hwang SR, Hook VY. Multiple domains of endopin 2A for serpin cross-class inhibition of papain. Archives of Biochemistry and Biophysics. 461: 219-24. PMID 17451636 DOI: 10.1016/j.abb.2007.02.036 |
0.082 |
|
| 1997 |
Hwang SR, Hook V. Molecular cloning of novel isoforms of alpha1-antichymotrypsin expressed in bovine neuroendocrine tissues Faseb Journal. 11: A1396. |
0.077 |
|
| 2021 |
Campeau A, Mills RH, Stevens T, Rossitto LA, Meehan M, Dorrestein P, Daly R, Nguyen TT, Gonzalez DJ, Jeste DV, Hook V. Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia. Molecular Psychiatry. PMID 34741130 DOI: 10.1038/s41380-021-01339-z |
0.062 |
|
| 1987 |
HOOK VYH, PALKOVITS M, AFFOLTER H. Biosynthesis and Maturation of Carboxypeptidase H Annals of the New York Academy of Sciences. 493: 394-396. DOI: 10.1111/j.1749-6632.1987.tb27222.x |
0.046 |
|
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