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Ching-Shih Chen - Publications

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Biochemistry
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44/420 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chang WL, Hsu LC, Leu WJ, Chen CS, Guh JH. Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation. Oncotarget. PMID 26447757 DOI: 10.18632/oncotarget.5655  0.312
2015 Liu TM, Ling Y, Woyach JA, Beckwith K, Yeh YY, Hertlein E, Zhang X, Lehman A, Awan F, Jones JA, Andritsos LA, Maddocks K, MacMurray J, Salunke SB, Chen CS, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 125: 284-95. PMID 25293770 DOI: 10.1182/Blood-2014-06-583518  0.316
2013 Lee SL, Chou CC, Chuang HC, Hsu EC, Chiu PC, Kulp SK, Byrd JC, Chen CS. Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines. Plos One. 8: e67149. PMID 23840605 DOI: 10.1371/Journal.Pone.0067149  0.31
2013 Ma Y, McCarty SK, Kapuriya NP, Brendel VJ, Wang C, Zhang X, Jarjoura D, Saji M, Chen CS, Ringel MD. Development of p21 activated kinase-targeted multikinase inhibitors that inhibit thyroid cancer cell migration. The Journal of Clinical Endocrinology and Metabolism. 98: E1314-22. PMID 23709653 DOI: 10.1210/Jc.2012-3937  0.327
2013 Yang YL, Huang PH, Chiu HC, Kulp SK, Chen CS, Kuo CJ, Chen HD, Chen CS. Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism. Biochemical and Biophysical Research Communications. 435: 107-12. PMID 23624506 DOI: 10.1016/J.Bbrc.2013.04.049  0.309
2013 Liu T, Ling Y, Phelps MA, Woyach JA, Hertlein EK, Towns WH, MacMurray J, Salunke SB, Chen C, Byrd JC, Johnson AJ. OSU-T315, An Integrin-Linked Kinase (ILK) Inhibitor, Induces Apoptosis By Targeting B Cell Receptor and CD49d Mediated AKT/ERK Activation In Chronic Lymphocytic Leukemia Cells Blood. 122: 2523-2523. DOI: 10.1182/Blood.V122.21.2523.2523  0.306
2011 Bai LY, Ma Y, Kulp SK, Wang SH, Chiu CF, Frissora F, Mani R, Mo X, Jarjoura D, Byrd JC, Chen CS, Muthusamy N. OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway. British Journal of Haematology. 153: 623-33. PMID 21470196 DOI: 10.1111/J.1365-2141.2010.08443.X  0.348
2011 Ching TT, Chiang WC, Chen CS, Hsu AL. Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity. Aging Cell. 10: 506-19. PMID 21348927 DOI: 10.1111/j.1474-9726.2011.00688.x  0.631
2011 Mani R, Frissora FW, Chen C, Byrd JC, Muthusamy N. OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase Blood. 118: 2499-2499. DOI: 10.1182/Blood.V118.21.2499.2499  0.304
2010 Oaks JJ, Mukhopadhyay A, Santhanam R, Saddoughi SA, Walker C, Neviani P, Harb JG, Ma Y, Verstovsek S, Marcucci G, Briesewitz R, Bittman R, Chen C, Quintas-Cardama A, Ogretmen B, et al. Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders Blood. 116: 775-775. DOI: 10.1182/Blood.V116.21.775.775  0.318
2009 Bai L, Ma Y, Kulp SK, Wang S, Chiu C, Frissora F, Mo X, Jarjoura D, Byrd JC, Chen C, Muthusamy N. OSU-DY7, a Novel D-Tyrosinol Derivative, Mediates Cytotoxicity in Chronic Lymphocytic Leukemia and Lymphoblastic Lymphoma through p38 Mitogen-Activated Protein Kinase Pathway. Blood. 114: 3778-3778. DOI: 10.1182/Blood.V114.22.3778.3778  0.311
2009 Oaks J, Neviani P, Mukhopadhyay A, Santhanam R, Ma Y, Mao C, Marcucci G, Chen C, Cortes J, Caligiuri MA, Hokland P, Huettner C, Koschmieder S, Cancelas J, Briesewitz R, et al. FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor. Blood. 114: 3259-3259. DOI: 10.1182/Blood.V114.22.3259.3259  0.315
2008 Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Research. 68: 1204-12. PMID 18281497 DOI: 10.1158/0008-5472.Can-07-2621  0.333
2007 Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, Shinohara M, Kulp SK, Kirschner LS, Saji M, Chen CS, Ringel MD. 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. Molecular Pharmacology. 72: 1124-31. PMID 17673571 DOI: 10.1124/Mol.107.037556  0.366
2006 Yacoub A, Park MA, Hanna D, Hong Y, Mitchell C, Pandya AP, Harada H, Powis G, Chen CS, Koumenis C, Grant S, Dent P. OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Molecular Pharmacology. 70: 589-603. PMID 16622074 DOI: 10.1124/Mol.106.025007  0.335
2006 Tong Z, Wu X, Chen CS, Kehrer JP. Cytotoxicity of a non-cyclooxygenase-2 inhibitory derivative of celecoxib in non-small-cell lung cancer A549 cells. Lung Cancer (Amsterdam, Netherlands). 52: 117-24. PMID 16497409 DOI: 10.1016/J.Lungcan.2005.12.003  0.366
2006 White VL, Zhang S, Lucas D, Chen C, Farag SS. OSU-HDAC42, a Novel Histone Deacetylase Inhibitor, Induces Apoptosis in a Caspase-Dependent Manner and Induces p21WAF1/CIP1 and p16 Expression in Multiple Myeloma Cell Lines. Blood. 108: 5078-5078. DOI: 10.1182/blood.v108.11.5078.5078  0.313
2006 Zhang S, White VL, Johnson A, Chen C, Farag SS. OSU03012, a Novel Celecoxib Derivative, Induces Apoptosis in Multiple Myeloma Cells Independently of Caspase Activation. Blood. 108: 5075-5075. DOI: 10.1182/blood.v108.11.5075.5075  0.31
2005 Kucab JE, Lee C, Chen CS, Zhu J, Gilks CB, Cheang M, Huntsman D, Yorida E, Emerman J, Pollak M, Dunn SE. Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours. Breast Cancer Research : Bcr. 7: R796-807. PMID 16168126 DOI: 10.1186/Bcr1294  0.365
2005 Tong Z, Wu X, Ovcharenko D, Zhu J, Chen CS, Kehrer JP. Neutrophil gelatinase-associated lipocalin as a survival factor. The Biochemical Journal. 391: 441-8. PMID 16060857 DOI: 10.1042/Bj20051020  0.411
2005 Gardner OS, Shiau CW, Chen CS, Graves LM. Peroxisome proliferator-activated receptor γ-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent Protein kinase II and protein kinase R: Correlation with endoplasmic reticulum stress Journal of Biological Chemistry. 280: 10109-10118. PMID 15649892 DOI: 10.1074/jbc.M410445200  0.336
2004 Lin HP, Kulp SK, Tseng PH, Yang YT, Yang CC, Chen CS, Chen CS. Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms. Molecular Cancer Therapeutics. 3: 1671-80. PMID 15634661  0.337
2004 Shaw YJ, Yang YT, Garrison JB, Kyprianou N, Chen CS. Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation. Journal of Medicinal Chemistry. 47: 4453-62. PMID 15317457 DOI: 10.1021/Jm049752K  0.304
2004 Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Research. 64: 4309-18. PMID 15205346 DOI: 10.1158/0008-5472.Can-03-4063  0.461
2004 Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS. 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer Research. 64: 1444-51. PMID 14973075 DOI: 10.1158/0008-5472.Can-03-2396  0.437
2003 Yang CC, Lin HP, Chen CS, Yang YT, Tseng PH, Rangnekar VM, Chen CS. Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells. The Journal of Biological Chemistry. 278: 25872-8. PMID 12738789 DOI: 10.1074/Jbc.M301744200  0.406
2002 Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, Chen CS. Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. Journal of the National Cancer Institute. 94: 1745-57. PMID 12464646 DOI: 10.1093/Jnci/94.23.1745  0.578
2002 Johnson AJ, Hsu AL, Lin HP, Song X, Chen CS. The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risks. The Biochemical Journal. 366: 831-7. PMID 12076251 DOI: 10.1042/Bj20020279  0.661
2002 Song X, Lin HP, Johnson AJ, Tseng PH, Yang YT, Kulp SK, Chen CS. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. Journal of the National Cancer Institute. 94: 585-91. PMID 11959891 DOI: 10.1093/Jnci/94.8.585  0.515
2001 Ching TT, Lin HP, Yang CC, Oliveira M, Lu PJ, Chen CS. Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif. The Journal of Biological Chemistry. 276: 43932-8. PMID 11555646 DOI: 10.1074/jbc.M105159200  0.551
2001 Ching TT, Hsu AL, Johnson AJ, Chen CS. Phosphoinositide 3-kinase facilitates antigen-stimulated Ca(2+) influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca(2+) entry mechanism. The Journal of Biological Chemistry. 276: 14814-20. PMID 11278575 DOI: 10.1074/jbc.M009851200  0.696
2001 Wang DS, Hsu AL, Chen CS. A phosphatidylinositol 3,4,5-trisphosphate analogue with low serum protein-binding affinity. Bioorganic & Medicinal Chemistry. 9: 133-9. PMID 11197333  0.547
2000 Wang DS, Ching TT, St Pyrek J, Chen CS. Biotinylated phosphatidylinositol 3,4,5-trisphosphate as affinity ligand. Analytical Biochemistry. 280: 301-7. PMID 10790314 DOI: 10.1006/Abio.2000.4525  0.598
2000 Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM, Chen CS. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. The Journal of Biological Chemistry. 275: 11397-403. PMID 10753955 DOI: 10.1074/Jbc.275.15.11397  0.698
2000 Hsu AL, Ching TT, Sen G, Wang DS, Bondada S, Authi KS, Chen CS. Novel function of phosphoinositide 3-kinase in T cell Ca2+ signaling. A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca2+ entry mechanism. The Journal of Biological Chemistry. 275: 16242-50. PMID 10748064 DOI: 10.1074/Jbc.M002077200  0.709
1999 Ching TT, Wang DS, Hsu AL, Lu PJ, Chen CS. Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4, 5-trisphosphate. The Journal of Biological Chemistry. 274: 8611-7. PMID 10085097  0.672
1998 Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Current Biology : Cb. 8: 1069-77. PMID 9768361 DOI: 10.1016/S0960-9822(98)70444-0  0.403
1998 Lu PJ, Hsu AL, Wang DS, Chen CS. Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca2+ influx. Biochemistry. 37: 9776-83. PMID 9657691 DOI: 10.1021/bi980163o  0.606
1998 Lu PJ, Hsu AL, Wang DS, Yan HY, Yin HL, Chen CS. Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry. 37: 5738-45. PMID 9548960 DOI: 10.1021/bi972551g  0.608
1998 Hsu AL, Lu PJ, Chen CS. Regulation of nuclear calcium uptake by inositol phosphates and external calcium. Biochemical and Biophysical Research Communications. 243: 653-6. PMID 9500990 DOI: 10.1006/bbrc.1998.8161  0.597
1998 Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. The Journal of Biological Chemistry. 273: 4465-9. PMID 9468499 DOI: 10.1074/Jbc.273.8.4465  0.455
1997 Lu P, Chen C. Selective Recognition of Phosphatidylinositol 3,4,5-Trisphosphate by a Synthetic Peptide Journal of Biological Chemistry. 272: 466-472. PMID 8995284 DOI: 10.1074/Jbc.272.1.466  0.379
1996 Rameh LE, Chen CS, Cantley LC. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell. 83: 821-30. PMID 8521499 DOI: 10.1016/0092-8674(95)90195-7  0.405
1996 Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 270: 29525-31. PMID 7493994 DOI: 10.1074/Jbc.270.49.29525  0.409
Low-probability matches (unlikely to be authored by this person)
2010 Walker C, Oaks JJ, Neviani P, Harb JG, Santhanam R, Ma Y, Marcucci G, Van Brocklyn J, Chen C, Bittman R, Perrotti D. PP2A Activating Drugs (PAD): Anti-Leukemic and Non-Toxic Activity of Two Novel and Non-Immunosuppressive FTY720 Derivatives Blood. 116: 2901-2901. DOI: 10.1182/Blood.V116.21.2901.2901  0.295
2011 Zhang S, Suvannasankha A, Crean CD, White VL, Chen CS, Farag SS. The novel histone deacetylase inhibitor, AR-42, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells. International Journal of Cancer. Journal International Du Cancer. 129: 204-13. PMID 20824695 DOI: 10.1002/ijc.25660  0.294
2013 ElGamal D, Zhong Y, Williams K, Wu C, Chen C, Lapalombella R, Byrd JC. PKC Inhibitor AEB071 Demonstrates Pre-Clinical Activity In Chronic Lymphocytic Leukemia Blood. 122: 4187-4187. DOI: 10.1182/blood.V122.21.4187.4187  0.293
2012 Chuang HC, Kapuriya N, Kulp SK, Chen CS, Shapiro CL. Differential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells. Breast Cancer Research and Treatment. 134: 649-59. PMID 22678161 DOI: 10.1007/S10549-012-2106-5  0.292
2011 Lee KH, Hsu EC, Guh JH, Yang HC, Wang D, Kulp SK, Shapiro CL, Chen CS. Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. The Journal of Biological Chemistry. 286: 39247-58. PMID 21917926 DOI: 10.1074/Jbc.M111.264598  0.291
2009 Huang PH, Wang D, Chuang HC, Wei S, Kulp SK, Chen CS. alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis. Carcinogenesis. 30: 1125-31. PMID 19420015 DOI: 10.1093/Carcin/Bgp112  0.29
2005 Tseng PH, Lin HP, Zhu J, Chen KF, Hade EM, Young DC, Byrd JC, Grever M, Johnson K, Druker BJ, Chen CS. Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance. Blood. 105: 4021-7. PMID 15665113 DOI: 10.1182/Blood-2004-07-2967  0.284
2004 Tseng PH, Lin HP, Hu H, Wang C, Zhu MX, Chen CS. The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. Biochemistry. 43: 11701-8. PMID 15362854 DOI: 10.1021/Bi049349F  0.282
2011 Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. Identification and characterization of a novel integrin-linked kinase inhibitor. Journal of Medicinal Chemistry. 54: 6364-74. PMID 21823616 DOI: 10.1021/Jm2007744  0.276
2014 Liu FL, Hsu JL, Lee YJ, Dong YS, Kung FL, Chen CS, Guh JH. Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation. European Journal of Pharmacology. 730: 90-101. PMID 24607408 DOI: 10.1016/j.ejphar.2014.02.029  0.275
2015 Plews RL, Mohd Yusof A, Wang C, Saji M, Zhang X, Chen CS, Ringel MD, Phay JE. A Novel Dual AMPK Activator/mTOR Inhibitor Inhibits Thyroid Cancer Cell Growth. The Journal of Clinical Endocrinology and Metabolism. 100: E748-56. PMID 25710562 DOI: 10.1210/jc.2014-1777  0.275
2006 Li J, Zhu J, Melvin WS, Bekaii-Saab TS, Chen CS, Muscarella P. A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 10: 207-14. PMID 16455452 DOI: 10.1016/J.Gassur.2005.07.025  0.274
2005 Shiau CW, Yang CC, Kulp SK, Chen KF, Chen CS, Huang JW, Chen CS. Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma. Cancer Research. 65: 1561-9. PMID 15735046 DOI: 10.1158/0008-5472.Can-04-1677  0.274
2007 Weng JR, Tsai CH, Kulp SK, Wang D, Lin CH, Yang HC, Ma Y, Sargeant A, Chiu CF, Tsai MH, Chen CS. A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells. Cancer Research. 67: 7815-24. PMID 17699787 DOI: 10.1158/0008-5472.Can-07-0794  0.273
2018 Weng JR, Dokla EME, Bai LY, Chen CS, Chiu SJ, Shieh TM. An AMPK Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma. Basic & Clinical Pharmacology & Toxicology. PMID 29394526 DOI: 10.1111/bcpt.12976  0.273
2010 Lin TY, Fenger J, Murahari S, Bear MD, Kulp SK, Wang D, Chen CS, Kisseberth WC, London CA. AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Blood. 115: 4217-25. PMID 20233974 DOI: 10.1182/Blood-2009-07-231985  0.272
2014 Chou CC, Lee KH, Lai IL, Wang D, Mo X, Kulp SK, Shapiro CL, Chen CS. AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Research. 74: 4783-95. PMID 24994714 DOI: 10.1158/0008-5472.Can-14-0135  0.271
2009 Ding H, Han C, Guo D, Wang D, Chen CS, D'Ambrosio SM. OSU03012 activates Erk1/2 and Cdks leading to the accumulation of cells in the S-phase and apoptosis. International Journal of Cancer. 123: 2923-30. PMID 18798257 DOI: 10.1002/ijc.23896  0.271
2007 Dewar BJ, Gardner OS, Chen CS, Earp HS, Samet JM, Graves LM. Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones. Molecular Pharmacology. 72: 1146-56. PMID 17686966 DOI: 10.1124/Mol.107.037549  0.269
2013 Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, ... ... Chen CS, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of Clinical Investigation. 123: 4144-57. PMID 23999433 DOI: 10.1172/Jci68951  0.268
2015 Dokla EM, Fang CS, Lai PT, Kulp SK, Serya RA, Ismail NS, Abouzid KA, Chen CS. Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators. Chemmedchem. PMID 26350292 DOI: 10.1002/Cmdc.201500371  0.266
2008 Wang YC, Kulp SK, Wang D, Yang CC, Sargeant AM, Hung JH, Kashida Y, Yamaguchi M, Chang GD, Chen CS. Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors. Cancer Research. 68: 2820-30. PMID 18413750 DOI: 10.1158/0008-5472.Can-07-1336  0.266
2006 Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Molecular Pharmacology. 70: 1534-41. PMID 16887935 DOI: 10.1124/Mol.106.023911  0.263
1998 Venkataraman C, Lu PJ, Buhl AM, Chen CS, Cambier JC, Bondada S. CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase. European Journal of Immunology. 28: 3003-16. PMID 9808169 DOI: 10.1002/(Sici)1521-4141(199810)28:10<3003::Aid-Immu3003>3.0.Co;2-W  0.262
2008 Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, Muthusamy N, Byrd JC. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood. 111: 275-84. PMID 17761520 DOI: 10.1182/Blood-2006-10-053884  0.262
2009 Wei S, Yang J, Lee SL, Kulp SK, Chen CS. PPARgamma-independent antitumor effects of thiazolidinediones. Cancer Letters. 276: 119-24. PMID 18790559 DOI: 10.1016/J.Canlet.2008.08.008  0.259
2008 Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, et al. OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Molecular Pharmacology. 73: 1168-84. PMID 18182481 DOI: 10.1124/Mol.107.042697  0.259
2004 Johnson A, Smith L, Zhu J, Heerema N, Guster S, Mone A, Grever M, Chen C, Byrd J. A Novel Celecoxib Derivative, OSU03012, Induces Cytotoxicity in Primary CLL Cells and Transformed B-Cell Lymphoma Via a Caspase and Bcl-2 Independent Mechanism. Blood. 104: 3471-3471. DOI: 10.1182/blood.v104.11.3471.3471  0.256
2015 Yan R, Chuang HC, Kapuriya N, Chou CC, Lai PT, Chang HW, Yang CN, Kulp SK, Chen CS. Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors. Journal of Medicinal Chemistry. 58: 2290-8. PMID 25689347 DOI: 10.1021/Jm501751B  0.256
2012 Booth L, Cruickshanks N, Ridder T, Chen CS, Grant S, Dent P. OSU-03012 interacts with lapatinib to kill brain cancer cells. Cancer Biology & Therapy. 13: 1501-11. PMID 22990204 DOI: 10.4161/Cbt.22275  0.255
2011 Chen MC, Chen CH, Chuang HC, Kulp SK, Teng CM, Chen CS. Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. Hepatology (Baltimore, Md.). 53: 148-59. PMID 21254166 DOI: 10.1002/Hep.23964  0.255
2005 Ding H, Han C, Zhu J, Chen CS, D'Ambrosio SM. Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9. International Journal of Cancer. 113: 803-10. PMID 15499625 DOI: 10.1002/ijc.20639  0.255
2016 Trikha P, Plews RL, Stiff A, Gautam S, Hsu V, Abood D, Wesolowski R, Landi I, Mo X, Phay J, Chen CS, Byrd J, Caligiuri M, Tridandapani S, Carson W. Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator. Oncoimmunology. 5: e1214787. PMID 27757311 DOI: 10.1080/2162402X.2016.1214787  0.254
2005 Johnson AJ, Smith LL, Zhu J, Heerema NA, Jefferson S, Mone A, Grever M, Chen CS, Byrd JC. A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism. Blood. 105: 2504-9. PMID 15454489 DOI: 10.1182/blood-2004-05-1957  0.254
2013 Mani R, Mao Y, Frissora FW, Chiang C, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X, Baskar S, Rader C, Phelps MA, Lee RJ, Chen C, et al. Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia Blood. 122: 4168-4168. DOI: 10.1182/Blood.V122.21.4168.4168  0.253
2014 El-Gamal D, Williams K, LaFollette TD, Cannon M, Blachly JS, Zhong Y, Woyach JA, Williams E, Awan FT, Jones J, Andritsos L, Maddocks K, Wu CH, Chen CS, Lehman A, et al. PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL. Blood. 124: 1481-91. PMID 25001469 DOI: 10.1182/blood-2014-05-574830  0.253
2010 Wei S, Kulp SK, Chen CS. Energy restriction as an antitumor target of thiazolidinediones. The Journal of Biological Chemistry. 285: 9780-91. PMID 20093366 DOI: 10.1074/Jbc.M109.065466  0.251
2005 Chen CS, Weng SC, Tseng PH, Lin HP, Chen CS. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. The Journal of Biological Chemistry. 280: 38879-87. PMID 16186112 DOI: 10.1074/jbc.M505733200  0.251
2017 Komar HM, Serpa G, Kerscher C, Schwoegl E, Mace TA, Jin M, Yang MC, Chen CS, Bloomston M, Ostrowski MC, Hart PA, Conwell DL, Lesinski GB. Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo. Scientific Reports. 7: 1787. PMID 28496202 DOI: 10.1038/S41598-017-01973-0  0.25
2009 Yang YT, Balch C, Kulp SK, Mand MR, Nephew KP, Chen CS. A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer. Neoplasia (New York, N.Y.). 11: 552-63, 3 p followin. PMID 19484144 DOI: 10.1593/Neo.09204  0.249
2015 Shirley LA, McCarty S, Yang MC, Saji M, Zhang X, Phay J, Ringel MD, Chen CS. Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target. Surgery. PMID 26549818 DOI: 10.1016/J.Surg.2015.10.016  0.247
2012 Bhola NE, Freilino ML, Joyce SC, Sen M, Thomas SM, Sahu A, Cassell A, Chen CS, Grandis JR. Antitumor mechanisms of targeting the PDK1 pathway in head and neck cancer. Molecular Cancer Therapeutics. 11: 1236-46. PMID 22491800 DOI: 10.1158/1535-7163.Mct-11-0936  0.246
2009 Ding H, Han C, Guo D, Wang D, Duan W, Chen CS, D'Ambrosio SM. Sensitivity to the non-COX inhibiting celecoxib derivative, OSU03012, is p21(WAF1/CIP1) dependent. International Journal of Cancer. 123: 2931-8. PMID 18798266 DOI: 10.1002/ijc.23895  0.243
2015 Tsai YT, Lozanski G, Lehman A, Sass EJ, Hertlein E, Salunke SB, Chen CS, Grever MR, Byrd JC, Lucas DM. BRAF(V600E) induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation. Leukemia Research. PMID 26350141 DOI: 10.1016/J.Leukres.2015.08.017  0.243
2012 Hsu JL, Ho YF, Li TK, Chen CS, Hsu LC, Guh JH. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. Biochemical Pharmacology. 84: 59-67. PMID 22490701 DOI: 10.1016/j.bcp.2012.03.023  0.243
2009 Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp SK, Chen CS, Giovannini M, Jacob A, Welling DB, Chang LS. Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. European Journal of Cancer (Oxford, England : 1990). 45: 1709-20. PMID 19359162 DOI: 10.1016/J.Ejca.2009.03.013  0.242
2006 Teresi RE, Shaiu CW, Chen CS, Chatterjee VK, Waite KA, Eng C. Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. International Journal of Cancer. 118: 2390-8. PMID 16425225 DOI: 10.1002/Ijc.21799  0.242
2016 Booth L, Shuch B, Albers T, Roberts JL, Tavallai M, Proniuk S, Zukiwski A, Wang D, Chen CS, Bottaro D, Ecroyd H, Lebedyeva IO, Dent P. Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function. Oncotarget. PMID 26887051 DOI: 10.18632/Oncotarget.7349  0.241
2011 Bush ML, Oblinger J, Brendel V, Santarelli G, Huang J, Akhmametyeva EM, Burns SS, Wheeler J, Davis J, Yates CW, Chaudhury AR, Kulp S, Chen CS, Chang LS, Welling DB, et al. AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. Neuro-Oncology. 13: 983-99. PMID 21778190 DOI: 10.1093/Neuonc/Nor072  0.24
2008 Park MA, Curiel DT, Koumenis C, Graf M, Chen CS, Fisher PB, Grant S, Dent P. PERK-dependent regulation of HSP70 expression and the regulation of autophagy. Autophagy. 4: 364-7. PMID 18216498 DOI: 10.4161/Auto.5593  0.24
2014 Tsai JS, Chuang LM, Chen CS, Liang CJ, Chen YL, Chen CY. Troglitazone and Δ2Troglitazone enhance adiponectin expression in monocytes/macrophages through the AMP-activated protein kinase pathway. Mediators of Inflammation. 2014: 726068. PMID 25328285 DOI: 10.1155/2014/726068  0.238
2006 Santhanam R, Neviani P, Eiring A, Oaks J, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Marcucci G, Gambacorti C, Roy D, Caligiuri MA, Bloomfield CD, Chen C, et al. FTY720, a New and Alternative Strategy for Treating Blast Crisis CML and Ph1 ALL Patients. Blood. 108: 288-288. DOI: 10.1182/Blood.V108.11.288.288  0.237
2006 Shiau CW, Huang JW, Wang DS, Weng JR, Yang CC, Lin CH, Li C, Chen CS. alpha-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. The Journal of Biological Chemistry. 281: 11819-25. PMID 16520381 DOI: 10.1074/jbc.M511015200  0.237
2008 Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. Molecular Cancer Therapeutics. 7: 800-8. PMID 18413793 DOI: 10.1158/1535-7163.MCT-07-0434  0.236
2013 Huang PH, Chuang HC, Chou CC, Wang H, Lee SL, Yang HC, Chiu HC, Kapuriya N, Wang D, Kulp SK, Chen CS. Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1. Science Signaling. 6: ra19. PMID 23512990 DOI: 10.1126/Scisignal.2003816  0.235
2019 Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Retraction: Sensitizing Estrogen Receptor-negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor. Molecular Cancer Therapeutics. 18: 869. PMID 30936413 DOI: 10.1158/1535-7163.Mct-19-0151  0.235
2013 Chan SH, Leu WJ, Hsu LC, Chang HS, Hwang TL, Chen IS, Chen CS, Guh JH. Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades. Biochemical Pharmacology. 86: 1564-75. PMID 24099795 DOI: 10.1016/j.bcp.2013.09.021  0.234
2018 Guh JH, Chang WL, Yang J, Lee SL, Wei S, Wang D, Kulp SK, Chen CS. Retraction of "Development of Novel Adenosine Monophosphate-Activated Protein Kinase Activators". Journal of Medicinal Chemistry. PMID 29772897 DOI: 10.1021/Acs.Jmedchem.8B00707  0.232
2006 West DA, Lucas DM, Davis ME, De Lay MD, Johnson AJ, Guster SE, Freitas MA, Parthun MR, Wang D, Kulp SK, Grever MR, Chen C, Byrd JC. The Novel Histone Deacetylase Inhibitor OSU-HDAC42 Has Class I and II Histone Deacetylase (HDAC) Inhibitory Activity and Represents a Novel Therapy for Chronic Lymphocytic Leukemia. Blood. 108: 2807-2807. DOI: 10.1182/Blood.V108.11.2807.2807  0.232
2007 Zhang S, Suvannasankha A, Crean CD, White VL, Johnson A, Chen CS, Farag SS. OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 4750-8. PMID 17699852 DOI: 10.1158/1078-0432.CCR-07-0136  0.231
2010 Guh JH, Chang WL, Yang J, Lee SL, Wei S, Wang D, Kulp SK, Chen CS. Development of novel adenosine monophosphate-activated protein kinase activators. Journal of Medicinal Chemistry. 53: 2552-61. PMID 20170185 DOI: 10.1021/Jm901773D  0.226
2009 Chiu HC, Kulp SK, Soni S, Wang D, Gunn JS, Schlesinger LS, Chen CS. Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent. Antimicrobial Agents and Chemotherapy. 53: 5236-44. PMID 19805568 DOI: 10.1128/Aac.00555-09  0.226
2011 Alinari L, Mahoney E, Patton J, Zhang X, Huynh L, Earl CT, Mani R, Mao Y, Yu B, Quinion C, Towns WH, Chen CS, Goldenberg DM, Blum KA, Byrd JC, et al. FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. Blood. 118: 6893-903. PMID 22042694 DOI: 10.1182/Blood-2011-06-363879  0.226
2019 Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS. Editor's Note: From the Cyclooxygenase-2 Inhibitor Celecoxib to a Novel Class of 3-Phosphoinositide-Dependent Protein Kinase-1 Inhibitors. Cancer Research. 79: 1716. PMID 30936080 DOI: 10.1158/0008-5472.Can-19-0502  0.223
2010 Weng JR, Omar HA, Kulp SK, Chen CS. Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents. Mini Reviews in Medicinal Chemistry. 10: 398-404. PMID 20370707 DOI: 10.2174/138955710791330945  0.222
2006 Sun J, Liu S, Yu J, Wei M, Mao C, Ding H, Kearney J, Huynh L, Paschka P, Wang D, Klisovic RB, Perrotti D, Chen C, Blum WG, Marcucci G. Characterization of HDACI OSU42 as a Novel Histone Deacetylase Inhibitor in AML Cell Lines. Blood. 108: 1988-1988. DOI: 10.1182/Blood.V108.11.1988.1988  0.221
2010 Baryawno N, Sveinbjörnsson B, Eksborg S, Chen CS, Kogner P, Johnsen JI. Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Research. 70: 266-76. PMID 20028853 DOI: 10.1158/0008-5472.CAN-09-0578  0.221
2008 Gao M, Yeh PY, Lu YS, Hsu CH, Chen KF, Lee WC, Feng WC, Chen CS, Kuo ML, Cheng AL. OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Research. 68: 9348-57. PMID 19010909 DOI: 10.1158/0008-5472.CAN-08-1642  0.221
2012 Jacob A, Oblinger J, Bush ML, Brendel V, Santarelli G, Chaudhury AR, Kulp S, La Perle KM, Chen CS, Chang LS, Welling DB. Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas. The Laryngoscope. 122: 174-89. PMID 22109824 DOI: 10.1002/Lary.22392  0.22
2015 Chou CC, Chuang HC, Salunke SB, Kulp SK, Chen CS. A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells. Oncotarget. 6: 8271-85. PMID 25821081 DOI: 10.18632/Oncotarget.3186  0.219
2010 Chandler HL, Webb TR, Barden CA, Thangavelu M, Kulp SK, Chen CS, Colitz CM. The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. Molecular Vision. 16: 2202-14. PMID 21139685  0.219
2012 Booth L, Cazanave SC, Hamed HA, Yacoub A, Ogretmen B, Chen CS, Grant S, Dent P. OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing. Cancer Biology & Therapy. 13: 224-36. PMID 22354011 DOI: 10.4161/Cbt.13.4.18877  0.218
2008 Yang J, Wei S, Wang DS, Wang YC, Kulp SK, Chen CS. Pharmacological exploitation of the peroxisome proliferator-activated receptor gamma agonist ciglitazone to develop a novel class of androgen receptor-ablative agents. Journal of Medicinal Chemistry. 51: 2100-7. PMID 18335975 DOI: 10.1021/Jm701212M  0.217
2015 Chang WL, Yu CC, Chen CS, Guh JH. Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry. Biochemical Pharmacology. 94: 12-21. PMID 25615907 DOI: 10.1016/j.bcp.2015.01.005  0.217
2010 Lucas DM, Alinari L, West DA, Davis ME, Edwards RB, Johnson AJ, Blum KA, Hofmeister CC, Freitas MA, Parthun MR, Wang D, Lehman A, Zhang X, Jarjoura D, Kulp SK, ... ... Chen CS, et al. The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. Plos One. 5: e10941. PMID 20532179 DOI: 10.1371/Journal.Pone.0010941  0.215
2017 Hsieh HY, Chuang HC, Shen FH, Detroja K, Hsin LW, Chen CS. Targeting breast cancer stem cells by novel HDAC3-selective inhibitors. European Journal of Medicinal Chemistry. 140: 42-51. PMID 28923385 DOI: 10.1016/j.ejmech.2017.08.069  0.215
2006 Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen CS, Chen TC, Schönthal AH. Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo Molecular Cancer. 5. PMID 16707021 DOI: 10.1186/1476-4598-5-19  0.214
2013 Chen C, VanHook AM. Science Signaling Podcast: 19 March 2013 Science Signaling. 6: pc8-pc8. DOI: 10.1126/Scisignal.2004109  0.214
2014 Chuang HC, Chou CC, Kulp SK, Chen CS. AMPK as a potential anticancer target - friend or foe? Current Pharmaceutical Design. 20: 2607-18. PMID 23859619  0.213
2005 Huang JW, Shiau CW, Yang YT, Kulp SK, Chen KF, Brueggemeier RW, Shapiro CL, Chen CS. Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells. Molecular Pharmacology. 67: 1342-8. PMID 15653552 DOI: 10.1124/Mol.104.007732  0.21
2009 Alinari L, Liu Q, Chen C, Yan F, Dalton JT, Lapalombella R, Zhang X, Lin T, Byrd JC, Baiocchi RA, Muthusamy N. FTY720 Demonstrates Promising in-Vitro and in-Vivo Pre-Clinical Activity by Down-Modulation of Cyclin D1 and Pakt in Mantle Cell Lymphoma. Blood. 114: 3728-3728. DOI: 10.1182/Blood.V114.22.3728.3728  0.21
2015 Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Oncotarget. PMID 26625202 DOI: 10.18632/Oncotarget.6427  0.21
2007 Sargeant AM, Klein RD, Rengel RC, Clinton SK, Kulp SK, Kashida Y, Yamaguchi M, Wang X, Chen CS. Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicologic Pathology. 35: 549-61. PMID 17562488 DOI: 10.1080/01926230701338966  0.208
2007 Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, Druker BJ, Cortes J, Marcucci G, Chen CS, Verrills NM, et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. The Journal of Clinical Investigation. 117: 2408-21. PMID 17717597 DOI: 10.1172/Jci31095  0.205
2016 Chu PC, Kulp SK, Bekaii-Saab T, Chen CS. Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer. Small Gtpases. 1-5. PMID 27936345 DOI: 10.1080/21541248.2016.1251383  0.205
2010 Lapalombella R, Andritsos L, Liu Q, May SE, Browning R, Pham LV, Blum KA, Blum W, Ramanunni A, Raymond CA, Smith LL, Lehman A, Mo X, Jarjoura D, Chen CS, et al. Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway. Blood. 115: 2619-29. PMID 19965642 DOI: 10.1182/Blood-2009-09-242438  0.203
2014 Hensley PJ, Desiniotis A, Wang C, Stromberg A, Chen CS, Kyprianou N. Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells. Plos One. 9: e86238. PMID 24497940 DOI: 10.1371/Journal.Pone.0086238  0.203
2011 Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology (Baltimore, Md.). 53: 1943-58. PMID 21391227 DOI: 10.1002/Hep.24293  0.203
2011 Wang B, Huang PH, Chen CS, Forsyth CJ. Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis. The Journal of Organic Chemistry. 76: 1140-50. PMID 21244075 DOI: 10.1021/Jo102478X  0.203
2013 Berman-Booty LD, Chu PC, Thomas-Ahner JM, Bolon B, Wang D, Yang T, Clinton SK, Kulp SK, Chen CS. Suppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent. Cancer Prevention Research (Philadelphia, Pa.). 6: 232-41. PMID 23275006 DOI: 10.1158/1940-6207.Capr-12-0057  0.202
2006 Huang JW, Shiau CW, Yang J, Wang DS, Chiu HC, Chen CY, Chen CS. Development of small-molecule cyclin D1-ablative agents. Journal of Medicinal Chemistry. 49: 4684-9. PMID 16854074 DOI: 10.1021/jm060057h  0.201
2006 Lin HY, Chen CS, Lin SP, Weng JR, Chen CS. Targeting histone deacetylase in cancer therapy. Medicinal Research Reviews. 26: 397-413. PMID 16450343 DOI: 10.1002/med.20056  0.201
2005 Lu Q, Wang DS, Chen CS, Hu YD, Chen CS. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. Journal of Medicinal Chemistry. 48: 5530-5. PMID 16107152 DOI: 10.1021/jm0503749  0.2
2013 Burns SS, Akhmametyeva EM, Oblinger JL, Bush ML, Huang J, Senner V, Chen CS, Jacob A, Welling DB, Chang LS. Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth. Cancer Research. 73: 792-803. PMID 23151902 DOI: 10.1158/0008-5472.Can-12-1888  0.2
2008 Neviani P, Santhanam R, Ma Y, Marcucci G, Byrd JC, Chen C, Cortes J, Caligiuri MA, Huettner C, Bhatia R, Roy D, Perrotti D. Activation of PP2A by FTY720 Inhibits Survival and Self-Renewal of the Ph(+) Chronic Myelogenous Leukemia (CML) CD34+/CD38− Stem Cell through the Simultaneous Suppression of BCR/ABL and BCR/ABL– independent Signals Blood. 112: 189-189. DOI: 10.1182/Blood.V112.11.189.189  0.199
2008 Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, Lu PJ, Lai MD, Chen CS. A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. The Journal of Biological Chemistry. 283: 26759-70. PMID 18650423 DOI: 10.1074/Jbc.M802160200  0.198
2008 Chen C. Potent inhibitors of the hedgehog signaling pathway Chemtracts. 21: 150-154.  0.198
2008 Weng JR, Tsai CH, Kulp SK, Chen CS. Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Letters. 262: 153-63. PMID 18314259 DOI: 10.1016/J.Canlet.2008.01.033  0.197
2007 Yang CC, Wang YC, Wei S, Lin LF, Chen CS, Lee CC, Lin CC, Chen CS. Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation. Cancer Research. 67: 3229-38. PMID 17409431 DOI: 10.1158/0008-5472.CAN-06-2759  0.196
2012 Lapalombella R, Yeh YY, Wang L, Ramanunni A, Rafiq S, Jha S, Staubli J, Lucas DM, Mani R, Herman SE, Johnson AJ, Lozanski A, Andritsos L, Jones J, Flynn JM, ... ... Chen CS, et al. Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals. Cancer Cell. 21: 694-708. PMID 22624718 DOI: 10.1016/J.Ccr.2012.03.040  0.196
2017 Murahari S, Jalkanen AL, Kulp SK, Chen CS, Modiano JF, London CA, Kisseberth WC. Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis. Bmc Cancer. 17: 67. PMID 28109246 DOI: 10.1186/S12885-017-3046-6  0.196
2014 Lai IL, Chou CC, Lai PT, Fang CS, Shirley LA, Yan R, Mo X, Bloomston M, Kulp SK, Bekaii-Saab T, Chen CS. Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells. Carcinogenesis. 35: 2203-13. PMID 24879635 DOI: 10.1093/Carcin/Bgu124  0.194
1992 Chen C. Electrofusion of protoplasts from Porphyra haitanensis and P. yezoensis thalli (Rhodophyta) Chinese Journal of Biotechnology. 8: 33-39. PMID 1457720  0.194
2012 Wei S, Chu PC, Chuang HC, Hung WC, Kulp SK, Chen CS. Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent. Plos One. 7: e47298. PMID 23071779 DOI: 10.1371/Journal.Pone.0047298  0.191
2011 Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. The Journal of Biological Chemistry. 286: 9968-76. PMID 21282102 DOI: 10.1074/Jbc.M110.203240  0.191
2010 Hamed HA, Yacoub A, Park MA, Eulitt P, Sarkar D, Dimitrie IP, Chen CS, Grant S, Curiel DT, Fisher PB, Dent P. OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins. Cancer Biology & Therapy. 9: 526-36. PMID 20107314 DOI: 10.4161/Cbt.9.7.11116  0.191
2007 Lu YS, Kashida Y, Kulp SK, Wang YC, Wang D, Hung JH, Tang M, Lin ZZ, Chen TJ, Cheng AL, Chen CS. Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma. Hepatology (Baltimore, Md.). 46: 1119-30. PMID 17654699 DOI: 10.1002/Hep.21804  0.189
2009 Wang D, Chuang HC, Weng SC, Huang PH, Hsieh HY, Kulp SK, Chen CS. alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. Journal of Medicinal Chemistry. 52: 5642-8. PMID 19708661 DOI: 10.1021/Jm9002457  0.188
2015 Mani R, Mao Y, Frissora FW, Chiang CL, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X, Yu L, Flynn J, Jones J, Andritsos L, Baskar S, ... ... Chen CS, et al. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. Leukemia. 29: 346-55. PMID 24947019 DOI: 10.1038/leu.2014.199  0.188
2006 Yang CC, Ku CY, Wei S, Shiau CW, Chen CS, Pinzone JJ, Ringel MD, Chen CS. Peroxisome proliferator-activated receptor gamma-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells. Molecular Pharmacology. 69: 1564-70. PMID 16452400 DOI: 10.1124/mol.105.018333  0.186
2009 Weng JR, Tsai CH, Omar HA, Sargeant AM, Wang D, Kulp SK, Shapiro CL, Chen CS. OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling. Carcinogenesis. 30: 1702-9. PMID 19706645 DOI: 10.1093/Carcin/Bgp202  0.186
2014 Chen CH, Chen MC, Wang JC, Tsai AC, Chen CS, Liou JP, Pan SL, Teng CM. Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1274-87. PMID 24520095 DOI: 10.1158/1078-0432.CCR-12-3909  0.185
2015 Hsu EC, Kulp SK, Huang HL, Tu HJ, Salunke SB, Sullivan NJ, Sun D, Wicha MS, Shapiro CL, Chen CS. Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae. Neoplasia (New York, N.Y.). 17: 497-508. PMID 26152358 DOI: 10.1016/J.Neo.2015.06.001  0.184
2008 Kisseberth WC, Murahari S, London CA, Kulp SK, Chen CS. Evaluation of the effects of histone deacetylase inhibitors on cells from canine cancer cell lines. American Journal of Veterinary Research. 69: 938-45. PMID 18593248 DOI: 10.2460/Ajvr.69.7.938  0.183
2004 Lu Q, Yang YT, Chen CS, Davis M, Byrd JC, Etherton MR, Umar A, Chen CS. Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. Journal of Medicinal Chemistry. 47: 467-74. PMID 14711316 DOI: 10.1021/jm0303655  0.182
2017 Chuang HC, Huang PH, Kulp SK, Chen CS. Pharmacological Strategies to Target Oncogenic KRAS Signaling in Pancreatic Cancer. Pharmacological Research. PMID 28077300 DOI: 10.1016/J.Phrs.2017.01.006  0.179
2011 Zimmerman B, Sargeant A, Landes K, Fernandez SA, Chen CS, Lairmore MD. Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma. Leukemia Research. 35: 1491-7. PMID 21802726 DOI: 10.1016/J.Leukres.2011.07.015  0.176
2009 Bush ML, Oblinger J, Kulp S, Chen C, Jacob A, Welling III DB, Chang L. Novel inhibitors of vestibular schwannomas and meningiomas Otolaryngology - Head and Neck Surgery. 141: P87-P88. DOI: 10.1016/J.Otohns.2009.06.268  0.174
2014 Lo JH, Kulp SK, Chen CS, Chiu HC. Sensitization of intracellular Salmonella enterica serovar Typhimurium to aminoglycosides in vitro and in vivo by a host-targeted antimicrobial agent. Antimicrobial Agents and Chemotherapy. 58: 7375-82. PMID 25267669 DOI: 10.1128/Aac.03778-14  0.174
2015 Chatterjee M, Ben-Josef E, Thomas DG, Morgan MA, Zalupski MM, Khan G, Andrew Robinson C, Griffith KA, Chen CS, Ludwig T, Bekaii-Saab T, Chakravarti A, Williams TM. Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer. Scientific Reports. 5: 10867. PMID 26065715 DOI: 10.1038/Srep10867  0.173
2015 Mani R, Chiang CL, Frissora FW, Yan R, Mo X, Baskar S, Rader C, Klisovic R, Phelps MA, Chen CS, Lee RJ, Byrd JC, Baiocchi R, Lee LJ, Muthusamy N. ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo. Experimental Hematology. PMID 25937048 DOI: 10.1016/J.Exphem.2015.04.008  0.172
2012 Shieh JM, Wei TT, Tang YA, Huang SM, Wen WL, Chen MY, Cheng HC, Salunke SB, Chen CS, Lin P, Chen CT, Wang YC. Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. Plos One. 7: e30240. PMID 22279574 DOI: 10.1371/journal.pone.0030240  0.172
2009 Omar HA, Sargeant AM, Weng JR, Wang D, Kulp SK, Patel T, Chen CS. Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. Molecular Pharmacology. 76: 957-68. PMID 19706731 DOI: 10.1124/Mol.109.058180  0.17
2016 Himmel LE, Lustberg MB, DeVries AC, Poi M, Chen CS, Kulp SK. Minocycline, a putative neuroprotectant, co-administered with doxorubicin-cyclophosphamide chemotherapy in a xenograft model of triple-negative breast cancer. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie. PMID 27555377 DOI: 10.1016/J.Etp.2016.08.001  0.17
2012 Hsu JL, Leong PK, Ho YF, Hsu LC, Lu PH, Chen CS, Guh JH. Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair. Cancer Letters. 319: 214-22. PMID 22261337 DOI: 10.1016/j.canlet.2012.01.004  0.168
2007 Garrison JB, Shaw YJ, Chen CS, Kyprianou N. Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity. Cancer Research. 67: 11344-52. PMID 18056461 DOI: 10.1158/0008-5472.Can-07-1662  0.166
2012 Lai MJ, Huang HL, Pan SL, Liu YM, Peng CY, Lee HY, Yeh TK, Huang PH, Teng CM, Chen CS, Chuang HY, Liou JP. Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo. Journal of Medicinal Chemistry. 55: 3777-91. PMID 22439863 DOI: 10.1021/jm300197a  0.162
2008 Sargeant AM, Rengel RC, Kulp SK, Klein RD, Clinton SK, Wang YC, Chen CS. OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Research. 68: 3999-4009. PMID 18483287 DOI: 10.1158/0008-5472.Can-08-0203  0.158
2009 Lapalombella R, Gowda A, Joshi T, Mehter N, Cheney C, Lehman A, Chen CS, Johnson AJ, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC. The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia. British Journal of Haematology. 144: 848-55. PMID 19183192 DOI: 10.1111/J.1365-2141.2008.07548.X  0.157
2015 Huang KY, Kao SH, Wang WL, Chen CY, Hsiao TH, Salunke SB, Chen JJ, Su KY, Yang SC, Hong TM, Chen CS, Yang PC. Small-molecule, T315, Promotes CBL-dependent Degradation of EGFR via Y1045 Autophosphorylation. American Journal of Respiratory and Critical Care Medicine. PMID 26583948 DOI: 10.1164/rccm.201502-0250OC  0.155
2012 Chu PC, Chuang HC, Kulp SK, Chen CS. The mRNA-stabilizing factor HuR protein is targeted by β-TrCP protein for degradation in response to glycolysis inhibition. The Journal of Biological Chemistry. 287: 43639-50. PMID 23115237 DOI: 10.1074/Jbc.M112.393678  0.154
2009 Contreras X, Schweneker M, Chen CS, McCune JM, Deeks SG, Martin J, Peterlin BM. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. The Journal of Biological Chemistry. 284: 6782-9. PMID 19136668 DOI: 10.1074/jbc.M807898200  0.153
2010 Liu Q, Alinari L, Chen CS, Yan F, Dalton JT, Lapalombella R, Zhang X, Mani R, Lin T, Byrd JC, Baiocchi RA, Muthusamy N. FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3182-92. PMID 20460491 DOI: 10.1158/1078-0432.Ccr-09-2484  0.15
2010 Tang YA, Wen WL, Chang JW, Wei TT, Tan YH, Salunke S, Chen CT, Chen CS, Wang YC. A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer. Plos One. 5: e12417. PMID 20856855 DOI: 10.1371/journal.pone.0012417  0.15
2015 Tseng YC, Kulp SK, Lai IL, Hsu EC, He WA, Frankhouser DE, Yan PS, Mo X, Bloomston M, Lesinski GB, Marcucci G, Guttridge DC, Bekaii-Saab T, Chen CS. Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia. Journal of the National Cancer Institute. 107. PMID 26464423 DOI: 10.1093/Jnci/Djv274  0.148
2007 Chen CS, Wang YC, Yang HC, Huang PH, Kulp SK, Yang CC, Lu YS, Matsuyama S, Chen CY, Chen CS. Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. Cancer Research. 67: 5318-27. PMID 17545612 DOI: 10.1158/0008-5472.Can-06-3996  0.147
2009 Wei S, Chuang HC, Tsai WC, Yang HC, Ho SR, Paterson AJ, Kulp SK, Chen CS. Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein. Molecular Pharmacology. 76: 47-57. PMID 19372209 DOI: 10.1124/Mol.109.055376  0.146
2006 Kulp SK, Chen CS, Wang DS, Chen CY, Chen CS. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5199-206. PMID 16951239 DOI: 10.1158/1078-0432.Ccr-06-0429  0.145
2019 Lai IL, Chou CC, Lai PT, Fang CS, Shirley LA, Yan R, Mo X, Bloomston M, K Kulp S, Bekaii-Saab T, Chen CS. Retraction: Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells. Carcinogenesis. 40: e16. PMID 31034565 DOI: 10.1093/carcin/bgz056  0.144
2020 Liva SG, Tseng YC, Dauki AM, Sovic MG, Vu T, Henderson SE, Kuo YC, Benedict JA, Zhang X, Remaily BC, Kulp SK, Campbell M, Bekaii-Saab T, Phelps MA, Chen CS, et al. Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor. Embo Molecular Medicine. e9910. PMID 31930715 DOI: 10.15252/Emmm.201809910  0.144
2013 Chu PC, Kulp SK, Chen CS. Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent. Carcinogenesis. 34: 2694-705. PMID 23864387 DOI: 10.1093/Carcin/Bgt251  0.143
2019 Kulp SK, Chen CS, Wang DS, Chen CY, Chen CS. Retraction: Antitumor Effects of a Novel Phenylbutyrate-based Histone Deacetylase Inhibitor, ()-HDAC-42, in Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 25: 2940. PMID 31043388 DOI: 10.1158/1078-0432.CCR-19-0731  0.14
2011 Hofmeister CC, Yang X, Pichiorri F, Chen P, Rozewski DM, Johnson AJ, Lee S, Liu Z, Garr CL, Hade EM, Ji J, Schaaf LJ, Benson DM, Kraut EH, Hicks WJ, ... ... Chen CS, et al. Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3427-34. PMID 21825263 DOI: 10.1200/JCO.2010.32.4962  0.137
2012 Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. Development of a novel class of glucose transporter inhibitors. Journal of Medicinal Chemistry. 55: 3827-36. PMID 22468970 DOI: 10.1021/Jm300015M  0.137
2009 Chiu HC, Yang J, Soni S, Kulp SK, Gunn JS, Schlesinger LS, Chen CS. Pharmacological exploitation of an off-target antibacterial effect of the cyclooxygenase-2 inhibitor celecoxib against Francisella tularensis. Antimicrobial Agents and Chemotherapy. 53: 2998-3002. PMID 19398640 DOI: 10.1128/Aac.00048-09  0.136
2011 Huang PH, Plass C, Chen CS. Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes. Molecular and Cellular Pharmacology. 3: 39-43. PMID 22468166 DOI: 10.4255/Mcpharmacol.11.06  0.135
2015 Chou YW, Lin FF, Muniyan S, Lin FC, Chen CS, Wang J, Huang CC, Lin MF. Cellular prostatic acid phosphatase (cPAcP) serves as a useful biomarker of histone deacetylase (HDAC) inhibitors in prostate cancer cell growth suppression. Cell & Bioscience. 5: 38. PMID 26185616 DOI: 10.1186/s13578-015-0033-y  0.134
2012 Lin HY, Kuo YC, Weng YI, Lai IL, Huang TH, Lin SP, Niu DM, Chen CS. Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent. The Prostate. 72: 1767-78. PMID 22539223 DOI: 10.1002/pros.22530  0.133
2009 Chiu HC, Soni S, Kulp SK, Curry H, Wang D, Gunn JS, Schlesinger LS, Chen CS. Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent. Journal of Biomedical Science. 16: 110. PMID 20003180 DOI: 10.1186/1423-0127-16-110  0.132
2011 Huang PH, Chen CH, Chou CC, Sargeant AM, Kulp SK, Teng CM, Byrd JC, Chen CS. Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. Molecular Pharmacology. 79: 197-206. PMID 20959362 DOI: 10.1124/Mol.110.067702  0.132
2007 Wei S, Lin LF, Yang CC, Wang YC, Chang GD, Chen H, Chen CS. Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma. Molecular Pharmacology. 72: 725-33. PMID 17569795 DOI: 10.1124/mol.107.035287  0.132
2013 Chen C. The influence of chinese herbal compound on the chronic restraint stress rat cortex and hippocampus BDNF, TrkB Journal of Bionanoscience. 7: 223-228. DOI: 10.1166/jbns.2013.1111  0.13
2016 Hsu EC, Kulp SK, Huang HL, Tu HJ, Chao MW, Tseng YC, Yang MC, Salunke SB, Sullivan NJ, Chen WC, Zhang J, Teng CM, Fu WM, Sun D, Wicha MS, ... ... Chen CS, et al. Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer. Carcinogenesis. PMID 26905583 DOI: 10.1093/Carcin/Bgw020  0.129
2015 Burnett JP, Korkaya H, Ouzounova MD, Jiang H, Conley SJ, Newman BW, Sun L, Connarn JN, Chen CS, Zhang N, Wicha MS, Sun D. Trastuzumab resistance induces EMT to transform HER2(+) PTEN(-) to a triple negative breast cancer that requires unique treatment options. Scientific Reports. 5: 15821. PMID 26522776 DOI: 10.1038/Srep15821  0.128
2014 Chou CC, Salunke SB, Kulp SK, Chen CS. Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents. Journal of Cellular Biochemistry. 115: 611-24. PMID 24166934 DOI: 10.1002/Jcb.24704  0.128
2016 Henderson SE, Ding LY, Mo X, Bekaii-Saab T, Kulp SK, Chen CS, Huang PH. Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42. Neoplasia (New York, N.Y.). 18: 765-774. PMID 27889645 DOI: 10.1016/J.Neo.2016.10.003  0.124
2016 Chu PC, Kulp SK, Chen CS. Corrigendum. Carcinogenesis. 38: 105-106. PMID 28064180 DOI: 10.1093/carcin/bgw117  0.12
2008 Lapalombella R, Yu B, Triantafillou G, Liu Q, Butchar JP, Lozanski G, Ramanunni A, Smith LL, Blum W, Andritsos L, Wang DS, Lehman A, Chen CS, Johnson AJ, Marcucci G, et al. Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. Blood. 112: 5180-9. PMID 18772452 DOI: 10.1182/Blood-2008-01-133108  0.116
2018 Chu PC, Lin PC, Wu HY, Lin KT, Wu C, Bekaii-Saab T, Lin YJ, Lee CT, Lee JC, Chen CS. Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. Oncogene. PMID 29559746 DOI: 10.1038/s41388-018-0222-3  0.112
2020 Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Retraction: Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Oncotarget. 11: 1096. PMID 32256981 DOI: 10.18632/oncotarget.27533  0.107
2012 Chiu HC, Lee SL, Kapuriya N, Wang D, Chen YR, Yu SL, Kulp SK, Teng LJ, Chen CS. Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus. Bioorganic & Medicinal Chemistry. 20: 4653-60. PMID 22750009 DOI: 10.1016/J.Bmc.2012.06.018  0.103
2011 Thudi NK, Shu ST, Martin CK, Lanigan LG, Nadella MV, Van Bokhoven A, Werbeck JL, Simmons JK, Murahari S, Kisseberth WC, Breen M, Williams C, Chen CS, McCauley LK, Keller ET, et al. Development of a brain metastatic canine prostate cancer cell line. The Prostate. 71: 1251-63. PMID 21321976 DOI: 10.1002/Pros.21341  0.101
1982 Chen C. Chinese with English abstract Acta Petrologica Mineralogica Et Analytica. 1: 71-72 & p 63.  0.1
2018 Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. Retraction of "Development of a Novel Class of Glucose Transporter Inhibitors". Journal of Medicinal Chemistry. PMID 29772905 DOI: 10.1021/Acs.Jmedchem.8B00708  0.095
2015 Salunke SB, Azad AK, Kapuriya NP, Balada-Llasat JM, Pancholi P, Schlesinger LS, Chen CS. Design and synthesis of novel anti-tuberculosis agents from the celecoxib pharmacophore. Bioorganic & Medicinal Chemistry. 23: 1935-43. PMID 25818768 DOI: 10.1016/j.bmc.2015.03.041  0.095
2013 Mishra A, La Perle KM, Sullivan L, Sams GH, Curphey DP, McConnell K, Qi J, Wong HK, Kulp SK, Fernandez S, Bradner JE, Marcucci G, Chen C, Porcu P, Caligiuri MA. Increased Expression Of IL-15 Promotes Cutaneous T-Cell Lymphomagenesis Via The Upregulation Of Histone Deacetylases: Evidence For Successful Preclinical Targeting Blood. 122: 1826-1826. DOI: 10.1182/Blood.V122.21.1826.1826  0.094
2015 Chen WC, Chang YS, Hsu HP, Yen MC, Huang HL, Cho CY, Wang CY, Weng TY, Lai PT, Chen CS, Lin YJ, Lai MD. Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer. Oncotarget. PMID 26556861 DOI: 10.18632/oncotarget.5976  0.094
2004 Roychowdhury S, Baiocchi RA, Vourganti S, Bhatt D, Blaser BW, Freud AG, Chou J, Chen CS, Xiao JJ, Parthun M, Chan KK, Eisenbeis CF, Ferketich AK, Grever MR, Chen CS, et al. Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder. Journal of the National Cancer Institute. 96: 1447-57. PMID 15467034 DOI: 10.1093/Jnci/Djh271  0.092
2014 Mao Y, Wang J, Zhao Y, Wu Y, Kwak KJ, Chen CS, Byrd JC, Lee RJ, Phelps MA, Lee LJ, Muthusamy N. A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 393-400. PMID 23969101 DOI: 10.1016/J.Nano.2013.08.001  0.092
1992 Chen C. Age-dependent changes in the adenylate cyclase system of rat ventral prostate Folia Pharmacologica Japonica. 99: 333-343. PMID 1592316  0.092
2001 Chen C. Risk of prostate cancer in relation to polymorphisms of metabolic genes Epidemiologic Reviews. 23: 30-35. PMID 11588852  0.089
2011 Lin YS, Shaw AY, Wang SG, Hsu CC, Teng IW, Tseng MJ, Huang TH, Chen CS, Leu YW, Hsiao SH. Identification of novel DNA methylation inhibitors via a two-component reporter gene system. Journal of Biomedical Science. 18: 3. PMID 21219604 DOI: 10.1186/1423-0127-18-3  0.087
2016 Cheng H, Xie Z, Jones WP, Wei XT, Liu Z, Wang D, Kulp SK, Wang J, Coss CC, Chen CS, Marcucci G, Garzon R, Covey JM, Phelps MA, Chan KK. Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents. The Aaps Journal. PMID 26943915 DOI: 10.1208/S12248-016-9876-3  0.087
2001 Chen C. A survey of the dietary nutritional composition of centenarians Chinese Medical Journal. 114: 1095-1097. PMID 11677774  0.087
2013 Lee SY, Huang Z, Kang TH, Soong RS, Knoff J, Axenfeld E, Wang C, Alvarez RD, Chen CS, Hung CF, Wu TC. Histone deacetylase inhibitor AR-42 enhances E7-specific CD8⁺ T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination. Journal of Molecular Medicine (Berlin, Germany). 91: 1221-31. PMID 23715898 DOI: 10.1007/s00109-013-1054-9  0.085
2001 Gagnon A, Dods P, Roustan-Delatour N, Chen CS, Sorisky A. Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes* * This work was supported by a grant (to A.S.) from the Medical Research Council of Canada. Endocrinology. 142: 205-212. PMID 28201220 DOI: 10.1210/endo.142.1.7902  0.079
2008 Andritsos LA, Johnson AJ, Lozanski G, Blum W, Kefauver C, Awan F, Smith LL, Lapalombella R, May SE, Raymond CA, Wang DS, Knight RD, Ruppert AS, Lehman A, Jarjoura D, ... Chen CS, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 2519-25. PMID 18427150 DOI: 10.1200/JCO.2007.13.9709  0.078
2015 Chen C. A practical guide for introducing Gibson assembly® gene constructs into chemically competent cells Biotechniques. 58: 144. DOI: 10.2144/000114268  0.075
2015 Berman-Booty LD, Thomas-Ahner JM, Bolon B, Oglesbee MJ, Clinton SK, Kulp SK, Chen CS, La Perle KM. Extra-prostatic transgene-associated neoplastic lesions in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Toxicologic Pathology. 43: 186-97. PMID 24742627 DOI: 10.1177/0192623314531351  0.074
2019 Chu PC, Kulp SK, Chen CS. Retraction: Corrigendum: Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent. Carcinogenesis. 40: e15. PMID 31034566 DOI: 10.1093/carcin/bgz057  0.073
2019 Chu PC, Kulp SK, Chen CS. Retraction: Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent. Carcinogenesis. 40: e14. PMID 31034564 DOI: 10.1093/carcin/bgz055  0.073
2014 Mao Y, Wang J, Zhao Y, Yan R, Li H, Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N, Phelps MA. Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 98: 160-5. PMID 24927402 DOI: 10.1016/J.Jpba.2014.05.022  0.071
1992 Gou D, Chen C. An efficient route toD-myo-inositol 1,3,4-triphosphate andD-myo-inositol 1,3,4,5-tetrakisphosphate Tetrahedron Letters. 33: 721-724. DOI: 10.1016/S0040-4039(00)77699-4  0.069
2012 Berman-Booty LD, Sargeant AM, Rosol TJ, Rengel RC, Clinton SK, Chen CS, Kulp SK. A review of the existing grading schemes and a proposal for a modified grading scheme for prostatic lesions in TRAMP mice. Toxicologic Pathology. 40: 5-17. PMID 22021166 DOI: 10.1177/0192623311425062  0.069
2009 Chen C. Drug-induced autoimmune liver injury Chinese Journal of Gastroenterology. 14: 221-224. DOI: 10.3969/j.issn.1008-7125.2009.04.009  0.061
1992 Chen C. Many-body electronic structures at transition-metal surfaces: Ni(001) Journal of Physics: Condensed Matter. 4: 9855-9868. DOI: 10.1088/0953-8984/4/49/013  0.059
1989 Chen C. Migration and transformation of industrial and occupational structures in Taiwan Ren Kou Xue Kan / Kuo Li Tai-Wan Ta Hsueh. 121-153. PMID 12159723  0.057
2006 Lin H, Chen C, Lin S, Weng J, Chen C. Targeting Histone Deacetylase in Cancer Therapy Cheminform. 37. DOI: 10.1002/chin.200638252  0.057
1991 Chen C. Migration selectivity and its consequences on the occupational structure in the Taipei metropolis In"Gu Munje Nonjip = Journal of Population Studies. 29-58. PMID 12222443  0.057
2003 Chen C. A QoS-based routing algorithm in multimedia satellite networks Ieee Vehicular Technology Conference. 58: 2703-2707.  0.055
1989 Chen C. Electrophysiologic properties of pancreatic beta-cells Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. 20: 268-270. PMID 2558414  0.055
2009 Oblinger J, Bush ML, Wheeler J, Chen C, Jacob A, Welling DB, Chang L. HDAC-42 as a potential radiosensitizer for human schwannomas Otolaryngology - Head and Neck Surgery. 141: P81-P81. DOI: 10.1016/J.Otohns.2009.06.248  0.055
1958 Chen C. Estrane derivatives-I Tetrahedron. 3: 43-48.  0.054
2001 Chen C. Aging and life satisfaction Social Indicators Research. 54: 57-79. DOI: 10.1023/A:1007260728792  0.054
2014 Jiang Y, Wang J, Rozewski DM, Kolli S, Wu CH, Chen CS, Yang X, Hofmeister CC, Byrd JC, Johnson AJ, Phelps MA. Sensitive liquid chromatography/mass spectrometry methods for quantification of pomalidomide in mouse plasma and brain tissue. Journal of Pharmaceutical and Biomedical Analysis. 88: 262-8. PMID 24095801 DOI: 10.1016/j.jpba.2013.08.036  0.053
2013 Chen C. Search for new physics effects involving top quarks and studies of jet shape and substructure at ATLAS Aip Conference Proceedings. 1560: 75-79. DOI: 10.1063/1.4826722  0.053
2007 Chen C. 3 Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 Receptor Progress in Medicinal Chemistry. 45: 111-167. PMID 17280903 DOI: 10.1016/S0079-6468(06)45503-X  0.052
1993 Chen C. Photoemission as a probe of electronic states in ultrathin magnetic overlayers: Correlation and hybridization effects Physical Review B. 48: 1318-1321. DOI: 10.1103/Physrevb.48.1318  0.051
1986 Chen C. PREGNANCY AFTER HUMAN OOCYTE CRYOPRESERVATION The Lancet. 327: 884-886. PMID 2870356 DOI: 10.1016/S0140-6736(86)90989-X  0.051
2000 Chen C. Theoretical study of synthetic reaction of tetrazole and tetrazolate anion International Journal of Quantum Chemistry. 80: 27-37. DOI: 10.1002/1097-461X(2000)80:1<27::AID-QUA2>3.0.CO;2-J  0.05
2000 Chen C. A modeling study of the episodic cross-frontal water transport over the inner shelf of the South Atlantic Bight Journal of Physical Oceanography. 30: 1722-1742.  0.05
1990 Chen C. Selectivity and differentials by type of move in Taiwan In"Gu Munje Nonjip = Journal of Population Studies. 43-57. PMID 12222439  0.049
2007 Andritsos LA, Johnson AJ, Blum W, Kefauver C, Awan F, Smith LL, Lapalombella R, Wang D, Knight RD, Chen C, Byrd JC. Unacceptable Toxicity of Lenalidomide When Administered to CLL Patients at Higher Doses. Blood. 110: 4727-4727. DOI: 10.1182/blood.v110.11.4727.4727  0.049
1973 Chen C. SEISMIC RESISTANT ANALYSIS OF HEAVY EQUIPMENT OF PWR PLANTS .  0.049
2014 Chen C. The Fitness of Information: Quantitative Assessments of Critical Evidence The Fitness of Information: Quantitative Assessments of Critical Evidence. 1-256. DOI: 10.1002/9781118858080  0.049
1991 Chen C. The diagnosis and treatment of Clostridium difficile enterocolitis Zhonghua Yi Xue Za Zhi. 71: 323-325, 24. PMID 1667496  0.048
2000 Chen C. Generalized additive mixed models Communications in Statistics - Theory and Methods. 29: 1257-1271.  0.048
2009 Chen C. Starting afresh Euroasia Semiconductor. 31: 20-25.  0.047
2003 Chen C. Revisiting the disengagement theory with differentials in the determinants of life satisfaction Social Indicators Research. 64: 209-224. DOI: 10.1023/A:1024718321860  0.046
1993 Chen C. Interface effects in strongly correlated metals: an exact-diagonalization study of the t-t′-J model Physics Letters A. 179: 49-54. DOI: 10.1016/0375-9601(93)91090-R  0.046
2014 Chen C. ENTERING 2014 International Surgery. 99: 1. DOI: 10.9738/0020-8868-99.1.1  0.045
2014 Chen C. Aging: Old question, new challenge Progress in Biochemistry and Biophysics. 41: 213-214. DOI: 10.3724/SP.J.1206.2014.00068  0.045
2005 Chen C. Study on special distribution characteristics of seismic activity and active fault in Fujian area Earthquake. 25: 102-108.  0.045
2007 Chen C. Immunity of analog devices against continuous radio-frequency disturbances Sae Technical Papers. DOI: 10.4271/2007-01-0358  0.044
2008 Chen C. Entry mode selection for international construction markets: The influence of host country related factors Construction Management and Economics. 26: 303-314. DOI: 10.1080/01446190701882382  0.044
1993 Chen C. Pairing and charge-density correlations in the three-dimensional negative-U Hubbard model on the fcc lattice Physical Review B. 47: 2861-2865. DOI: 10.1103/Physrevb.47.2861  0.043
1998 Chen C. A study on seawater apparent heavy metal complexation capacity in the Haikou Bay Acta Oceanologica Sinica. 17: 327-336.  0.043
2010 Chen C. UNEP institutional reform with its impact on developing countries Power Shifts and Global Governance: Challenges From South and North. 301-320. DOI: 10.7135/UPO9781843318842.018  0.043
2001 Chen C. Heterosynaptic LTP in early development Neuron. 31: 510-512. PMID 11545708 DOI: 10.1016/S0896-6273(01)00405-6  0.043
1978 Chen C. Petrochemistry and origin of pleistocene volcanic rocks from northern Taiwan Bulletin Volcanologique. 41: 513-528. DOI: 10.1007/BF02597384  0.042
1990 Chen C. Novel many-body effects in the photoemission spectrum of ultrathin bcc-cobalt films Physical Review Letters. 64: 2176-2179. DOI: 10.1103/Physrevlett.64.2176  0.041
1974 Chen C. Seismic resistant design of safety class structures and equipment Nuclear Engineering and Design. 30: 100-110. DOI: 10.1016/0029-5493(74)90155-1  0.041
2016 Chen C. Solving the puzzle of corporate governance of state-owned enterprises: The path of the Temasek model in Singapore and lessons for China Northwestern Journal of International Law and Business. 36: 303-370.  0.04
1988 Chen C. Sommerfeld constant and superconducting gaps determined in a two-band model: Application to La2-xSrxCuO4 Physica C: Superconductivity and Its Applications. 152: 111-115. DOI: 10.1016/0921-4534(88)90079-2  0.04
1994 Chen C. Interface hybridization and spectral distribution in strongly correlated itinerant magnetic systems Physical Review B. 50: 14539-14545. DOI: 10.1103/Physrevb.50.14539  0.04
2002 Chen C. Sorption isotherms of sweet potato slices Biosystems Engineering. 83: 85-95. DOI: 10.1006/bioe.2002.0093  0.039
1997 Chen C. Regionally sustainable development and the development of industries Acta Geographica Sinica. 52.  0.038
1994 Chen C. Raman-regime dispersion relation for relativistic traveling wave tubes Ieee International Conference On Plasma Science. 199.  0.036
2015 Chen C. In the Shadow of the Gestapo: German Secret Police Intelligence in East Asia, 1939–1945 International Journal of Intelligence and Counterintelligence. 28: 775-799. DOI: 10.1080/08850607.2015.1051840  0.036
1992 Chen C. Interaction-driven transfer of spectral weight in the epitaxial monolayer of Ni on Cu(001) Physical Review B. 45: 13811-13814. DOI: 10.1103/Physrevb.45.13811  0.035
2005 Chen C. Measuring the movement of a research paradigm Proceedings of Spie - the International Society For Optical Engineering. 5669: 63-76. DOI: 10.1117/12.602251  0.035
2004 Chen C. Rebellion against the polio vaccine in Nigeria: implications for humanitarian policy African Health Sciences. 4: 205-207. PMID 15687078  0.035
1993 Chen C. Superconductivity in the fcc negative-U Hubbard model: From two to three dimensions Physical Review B. 48: 6683-6686. DOI: 10.1103/Physrevb.48.6683  0.035
2005 Chen C. Infrastructure - The essential enabler Cim Bulletin. 98: 29-31.  0.035
2006 Chen C. In Situ Measurement of Microclimate for the Plantlets cultured In Vitro Biosystems Engineering. 95: 413-423. DOI: 10.1016/j.biosystemseng.2006.08.001  0.034
2007 Chen C. The formation of point-pattern fabric with yarn-structured form Journal of Soochow University Engineering Science Edition. 27: 65-67.  0.034
1995 Chen C. Electron correlation and heavy-fermion states in the Hubbard model Physica B: Physics of Condensed Matter. 206: 729-731. DOI: 10.1016/0921-4526(94)00569-H  0.034
2010 Omar HA, Berman-Booty L, Kulp SK, Chen CS. Energy restriction as an antitumor target. Future Oncology (London, England). 6: 1675-9. PMID 21142654 DOI: 10.2217/Fon.10.130  0.033
1986 Chen C. Chinese concepts of modeling hyperconcentrated streamflow and debris flow In: Proc. Third Int. Symp. On River Sedimentation, Central Theme, Estuarine and Coastal Sedimentation, (Jackson, U.S.a.: Mar..  0.033
2013 Chen C. Shifting interests: Whitlam, Britain and French nuclear tests in the South Pacific Australian Journal of Politics and History. 59: 196-211. DOI: 10.1111/ajph.12011  0.033
2000 Chen C. Integrated suppliers of SCADA/EMS/DMS in regional dispatching center Dianli Xitong Zidonghue/Automation of Electric Power Systems. 24: 68.  0.033
2013 Chen C. [Strategy of prevention and treatment on neonatal necrotizing enterocolitis] Zhonghua Er Ke Za Zhi. Chinese Journal of Pediatrics. 51: 321-325. PMID 23941835  0.033
2007 Chen C. Social networks at Sempra Energy's IT division are key to building strategic capabilities Global Business and Organizational Excellence. 26: 16-24. DOI: 10.1002/joe.20129  0.032
2006 Chen C. Varicocele in male factor infertility: Role of laparoscopic varicocelectomy International Surgery. 91. PMID 17436610  0.032
2012 Chen C. Numerical simulation analysis of soil nailing wall based on FLAC during the excavation of the foundation pit Advanced Materials Research. 594: 2906-2914. DOI: 10.4028/www.scientific.net/AMR.594-597.2906  0.032
1986 Chen C. Bingham plastic or Bagnold's dilatant fluid as a rheological model of debris flow? In: Proc. Third Int. Symp. On River Sedimentation, Central Theme, Estuarine and Coastal Sedimentation, (Jackson, U.S.a.: Mar..  0.032
1994 Chen C. Pierce-type dispersion relation for an intense relativistic electron beam interacting with a slow-wave structure Physics of Plasmas. 1: 167-170.  0.031
2010 Chen C. The Worm's-eye view: Using ethnography to illuminate labor politics and institutional change in contemporary China Contemporary Chinese Politics: New Sources, Methods, and Field Strategies. 129-144. DOI: 10.1017/CBO9780511762512.010  0.031
1990 Chen C. Surface photoemission and inverse photoemission in a periodic-cluster model of bcc iron: A many-body solution Physical Review B. 41: 5031-5039. DOI: 10.1103/PhysRevB.41.5031  0.031
2005 Chen C. More. Clearer. Faster. - It's all about information technology Cim Bulletin. 98: 17-23.  0.031
1994 Chen C. High-spin magnetic heavy-fermion states at ferromagnet/heavy-fermion interfaces Physica B: Physics of Condensed Matter. 194: 1343-1344. DOI: 10.1016/0921-4526(94)91001-4  0.031
2014 Chen C. Study of a new type of nanometer materials in interior design Applied Mechanics and Materials. 484: 43-46. DOI: 10.4028/www.scientific.net/AMM.484-485.43  0.031
2013 Chen C. Analysis of the impact of noise on the value of real estate based on CVM International Journal of Applied Environmental Sciences. 8: 1305-1311.  0.031
1980 Chen C. Non-marine setting of petroleum in the Sungliao basin of northeastern China Journal of Petroleum Geology. 2: 233-264.  0.031
2012 Chen C. Polyhedra scanning revisited Acm Sigplan Notices. 47: 499-508. DOI: 10.1145/2345156.2254123  0.031
2012 Chen C. Polyhedra scanning revisited Proceedings of the Acm Sigplan Conference On Programming Language Design and Implementation (Pldi). 499-508. DOI: 10.1145/2254064.2254123  0.031
2013 Chen C. Identifying the b quark inside a boosted hadronically decaying top quark using jet substructure in its center-of-mass frame Physical Review D - Particles, Fields, Gravitation and Cosmology. 88. DOI: 10.1103/PhysRevD.88.074009  0.03
2005 Chen C. Teck Cominco finds new opportunity Cim Bulletin. 98: 16-17.  0.03
2006 Chen C. Human resources: Trading up Cim Magazine. 1: 35-37.  0.029
1992 Chen C. Extended commuting and migration in the Taipei metropolitan area In"Gu Munje Nonjip = Journal of Population Studies. 161-183. PMID 12222482  0.029
1991 Chen C. Theoretical and experimental studies of cyclotron autoresonance maser amplifiers . 184.  0.028
2001 Chen C. Design for the environment: A quality-based model for green product development Management Science. 47: 250-263.  0.028
2004 Chen C. The approach for the integrated assessment of energy options and health benefit. IES project: Shanghai case study Annual Fuels and Lubes Asia Conference and Exhibition. 10.  0.028
2015 Chen C. Meet our editorial board member Current Drug Targets. 16: 1563.  0.028
1975 Chen C. REVIEWING FORECASTING TECHNIQUES Power. 119: 48-49.  0.028
1990 Chen C. Surface magnetism in an exactly soluble many-body periodic-cluster model of bcc iron Physical Review B. 41: 1320-1326. DOI: 10.1103/Physrevb.41.1320  0.028
1979 Chen C. Immunological infertility - management and prognosis Clinics in Obstetrics and Gynaecology. 6: 403-423. PMID 389522  0.027
2000 Chen C. Research and application of a new type of anticorrosive packing and internal Petrochemical Technology. 29.  0.027
2006 Chen C. Information visualization: Beyond the horizon Information Visualization: Beyond the Horizon. 1-316. DOI: 10.1007/1-84628-579-8  0.027
2015 Chen C. Contemporary prospects and voices of the future Asian Americans in Michigan: Voices From the Midwest. 283-285.  0.026
2006 Chen C. From filial piety to religious piety: Evangelical christianity reconstructing Taiwanese immigrant families in the United States International Migration Review. 40: 573-602. DOI: 10.1111/j.1747-7379.2006.00032.x  0.026
2014 Chen C. Study of new environmentally friendly materials in interior design Applied Mechanics and Materials. 484: 47-51. DOI: 10.4028/www.scientific.net/AMM.484-485.47  0.026
1986 Chen C. EXPERIMENTAL INVESTIGATION OF GAS BEARINGS WITH TANGENTIAL INLETS FOR 400,000 rpm TURBINES Jichuang Yu Yeya. 34-38.  0.026
2002 Chen C. Analysis of calculating method shrinkage in length of silk fabrics present Journal of Soochow University Engineering Science Edition. 22: 7-11.  0.026
2015 Chen C. New methods and development trend of modern Lingnan architectural creation Advances in Civil Engineering and Building Materials Iv - Selected and Peer Reviewed Papers From the 2014 4th International Conference On Civil Engineering and Building Materials, Cebm 2014. 7-12.  0.026
2014 Chen C. Accidental pilgrims: Modernity, migration, and Christian conversion among contemporary Taiwanese Americans Encountering Modernity: Christianity in East Asia and Asian America. 95-115.  0.026
2015 Chen C. Identification of a bottom quark-antiquark pair in a single jet with high transverse momentum and its application Physical Review D - Particles, Fields, Gravitation and Cosmology. 92. DOI: 10.1103/PhysRevD.92.093010  0.025
2006 Chen C. Finding answers (and more questions) through research Ot Practice. 11: 9-10.  0.025
2015 Chen C. High-generation organometallic rotaxane dendrimer Science China Chemistry. 58: 1089. DOI: 10.1007/s11426-015-5450-6  0.025
2016 Chen C. Superior cloning performance with SGI-DNA gibson assembly® kits Biotechniques. 60: 151-152. DOI: 10.2144/000114394  0.025
1999 Chen C. Time to steady-state for drugs with capacity-limited elimination Biopharmaceutics and Drug Disposition. 20: 231-232. PMID 10440799 DOI: 10.1002/(SICI)1099-081X(199905)20:4<231::AID-BDD180>3.0.CO;2-5  0.024
1968 Chen C. Pleistocene pteropods in pelagic sediments Nature. 219: 1145-1149. DOI: 10.1038/2191145a0  0.024
1997 Chen C. Chemistry for Pharmacy and the Life Sciences: Including Pharmacology and Biomedical Science.Gareth Thomas The Quarterly Review of Biology. 72: 116-116. DOI: 10.1086/419754  0.024
2006 Chen C. A household-based convoy and the reciprocity of support exchange between adult children and noncoresiding parents Journal of Family Issues. 27: 1100-1136. DOI: 10.1177/0192513X06288122  0.024
1995 Chen C. Response [2] Science. 267: 437.  0.024
2013 Chen C. Identifying the boosted hadronically decaying top quark using jet substructure in its center-of-mass frame Physical Review D - Particles, Fields, Gravitation and Cosmology. 87. DOI: 10.1103/PhysRevD.87.074007  0.024
2009 Chen C. China's Integration with the Global Economy: WTO Accession, Foreign Direct Investment and International Trade China's Integration With the Global Economy: Wto Accession, Foreign Direct Investment and International Trade.  0.023
1987 Chen C. The mathematical model and computer simulation of an lci drive Electric Machines and Power Systems. 13: 195-206. DOI: 10.1080/07313568708909235  0.023
2011 Chen C. Permanent magnet linear alternator magnetic field analysis Asee Annual Conference and Exposition, Conference Proceedings.  0.023
2011 Chen C. "We have all become students of color now": The California student movement and the rhetoric of privilege South Atlantic Quarterly. 110: 559-564. DOI: 10.1215/00382876-1162606  0.023
2004 Chen C. Multiscale topological structures in quantum spin chains Physical Review B - Condensed Matter and Materials Physics. 70. DOI: 10.1103/Physrevb.70.092404  0.022
1995 Chen C. Binding number and toughness for matching extension Discrete Mathematics. 146: 303-306. DOI: 10.1016/0012-365X(94)00175-5  0.022
1998 Chen C. Superconvergence for L2-projection in finite elements Chinese Science Bulletin. 43: 22-24.  0.022
1974 Chen C. Realizability of Communication Nets: An Application of the Zadeh Criterion Ieee Transactions On Circuits and Systems. 21: 150-151. DOI: 10.1109/TCS.1974.1083810  0.021
1988 Chen C. Pregnancies after human oocyte cryopreservation Annals of the New York Academy of Sciences. 541: 541-549. PMID 3195932  0.021
1992 Chen C. Theory of electron-cyclotron-resonance laser accelerators Physical Review A. 46: 6654-6661. DOI: 10.1103/PhysRevA.46.6654  0.021
2003 Chen C. Prediction of longitudinal variations in temperature and relative humidity for evaporative cooling greenhouses International Agricultural Engineering Journal. 12: 143-164.  0.021
2014 Chen C. Recognition International Surgery. 99: 97. DOI: 10.9738/0020-8868-99.2.97  0.021
2011 Chen C. Government audit and national economic security Communications in Computer and Information Science. 232: 157-163. DOI: 10.1007/978-3-642-23998-4_24  0.02
1995 Chen C. A simple criterion for global exponential stabilizability of nonlinear multiple time-delay singularly perturbed systems International Journal of Control. 62: 1197-1208. DOI: 10.1080/00207179508921591  0.02
2013 Chen C. Discussion of 'Government ownership, corporate governance and tax aggressiveness: Evidence from China' Accounting and Finance. 53: 1053-1059. DOI: 10.1111/acfi.12054  0.019
2014 Chen C. Traumatic optic neuropathy the many presentations and treatment options Neuro-Ophthalmology. 38: 105-106. DOI: 10.3109/01658107.2013.874457  0.019
1989 Chen C. Preliminary application of the computer technique to GuQin music research Journal of Computer Science and Technology. 4: 85-96. DOI: 10.1007/BF02943992  0.019
1991 Chen C. Calculating the conditions of lubrication of the piston skirt Schmierungstechnik. 22: 17-19.  0.019
2000 Chen C. General report on food and nutrition surveillance in 1998 and policy recommendation Wei Sheng Yan Jiu = Journal of Hygiene Research. 29: 258-262. PMID 2003051011  0.018
2001 Chen C. Review of research on ultraviolet and deep-UV nonlinear optical crystals in the last decade Pacific Rim Conference On Lasers and Electro-Optics, Cleo - Technical Digest. 2.  0.018
1999 Chen C. The main schools of TCM in Zhejiang Zhonghua Yi Shi Za Zhi (Beijing, China : 1980). 29: 235-238. PMID 11624245  0.018
1987 Chen C. Negative u centers and local lattice vibration in charge disproportionation system Chinese Physics Letters. 4: 489-492. DOI: 10.1088/0256-307X/4/11/003  0.018
2006 Chen C. Mining can take you places Cim Magazine. 1.  0.017
2012 Chen C. New approach to identifying boosted hadronically decaying particles using jet substructure in its center-of-mass frame Physical Review D - Particles, Fields, Gravitation and Cosmology. 85. DOI: 10.1103/PhysRevD.85.034007  0.017
2015 Chen C. The research of novel practical teaching system on higher vocational business English based on job skills on small and medium sized foreign trade enterprises Engineering Technology, Engineering Education and Engineering Management - International Conference On Engineering Technology, Engineering Education and Engineering Management, Eteeem 2014. 219-222.  0.017
2002 Chen C. Physical design with multiple on-chip voltages Proceedings of the International Symposium On Physical Design. 118.  0.017
2006 Chen C. Laparoscopic myomectomy for large myomas International Surgery. 91. PMID 17436607  0.017
2005 Chen C. Gibraltar reopened Cim Bulletin. 98: 32-33.  0.016
2015 Chen C. Preprint publication option. International Surgery. 100: 387. PMID 25785313 DOI: 10.9738/0020-8868-100.3.i  0.016
2005 Chen C. Mining SMART Cim Bulletin. 98: 12-13.  0.015
1995 Chen C. A short-tailed demodectic mite and Demodex canis infestation in a Chihuahua Dog Veterinary Dermatology. 6: 227-229.  0.015
2015 Chen C. Courageous Dedicated Research. International Surgery. 100: 1159. PMID 26595488 DOI: 10.9738/0020-8868-100.7.i  0.015
2003 Chen C. Helping graduates to get professional employment Asee Annual Conference Proceedings. 9209-9214.  0.015
2014 Chen C. [Focus on the application of digital techniques in obstetrics and gynecology] Zhonghua Fu Chan Ke Za Zhi. 49: 81-83. PMID 24739636  0.014
2005 Chen C. A self of one's own Taiwanese immigrant women and religious conversion Gender and Society. 19: 336-357. DOI: 10.1177/0891243204273125  0.014
2011 Chen C. [Expert's Comment] Zhonghua Er Ke Za Zhi. Chinese Journal of Pediatrics. 49: 450. PMID 21924059  0.013
1971 Chen C. Supervision of the high risk foetus in labour Berita Jururawat. 11: 33-34. PMID 5210384  0.013
1990 Chen C. Computational determination of the size of gap between piston stem and cylinder barrel Schmierungstechnik. 21: 333-334.  0.013
2002 Chen C. Treatment of facial peripheral paralysis with wasp cream guasha in 42 cases Chinese Journal of Clinical Rehabilitation. 6: 2975.  0.012
1994 Chen C. A new experimentally observable resonance in a free-electron laser with strong guide magnetic field Nuclear Inst. and Methods in Physics Research, A. 341. DOI: 10.1016/0168-9002(94)90460-X  0.012
1964 Chen C. Pteropod ooze from Bermuda pedestal Science. 144: 60-62.  0.012
1992 Chen C. Histological study of tissues surrounding an overloaded mandibular apatite implant and its antagonist teeth at three months Kokubyo Gakkai Zasshi. the Journal of the Stomatological Society, Japan. 59: 479-511. PMID 1522382  0.012
2014 Chen C. A novel particle swarm algorithm for online trading customer classification Applied Mechanics and Materials. 644: 2181-2184. DOI: 10.4028/www.scientific.net/AMM.644-650.2181  0.011
2004 Chen C. United states and European Union approaches to internet jurisdiction and their impact on e-commerce University of Pennsylvania Journal of International Economic Law. 25: 423-454.  0.011
2001 Chen C. Moisture measurement of grain using humidity sensors Transactions of the American Society of Agricultural Engineers. 44: 1241-1245.  0.011
1999 Chen C. Recurrence formula for radial matrix elements of two-dimensional isotropic harmonic oscillator Guangzi Xuebao/Acta Photonica Sinica. 28: 588-590.  0.01
2011 Chen C. China's military legislation construction in 2009 Chinese Academy of Social Sciences Yearbooks: Legal Development. 5: 97-117.  0.01
2006 Chen C. Coal and oil sands news: Energizing the future at Prairie Mines Cim Magazine. 1: 10-11.  0.01
2009 Chen C. Characteristics of FDI firms in china after WTO accession China's Integration With the Global Economy: Wto Accession, Foreign Direct Investment and International Trade. 101-124.  0.01
2015 Chen C. Reader easy access. International Surgery. 100: 579. PMID 25875535 DOI: 10.9738/0020-8868-100.4.i  0.01
2015 Chen C. The foundation of International Surgery International Surgery. 100: 967. DOI: 10.9738/0020-8868-100.6.i  0.01
2015 Chen C. Taking stock International Surgery. 100: 1. DOI: 10.9738/0020-8868-100.1.1  0.01
2015 Chen C. Caught Theater. 45: 43-75. DOI: 10.1215/01610775-3095494  0.01
2015 Chen C. Preface Pigments in Fruits and Vegetables. v-vi. DOI: 10.1007/978-1-4939-2356-4  0.01
2014 Chen C. Professor Earl R. Owen--in memoriam International Surgery. 99: 299. PMID 25058755 DOI: 10.9738/0020-8868-99.4.299  0.01
2014 Chen C. Curiosity International Surgery. 99: 195. PMID 24833137 DOI: 10.9738/0020-8868-99.3.195  0.01
2014 Chen C. Doing things the right way International Surgery. 99: 492. DOI: 10.9738/0020-8868-99.5.492  0.01
2014 Chen C. On building an English website for Tujia traditional culture Wit Transactions On Information and Communication Technologies. 49: 1019-1023. DOI: 10.2495/ICIE131242  0.01
2014 Chen C. Mapping scientific frontiers: The quest for knowledge visualization Mapping Scientific Frontiers: the Quest For Knowledge Visualization. 1-344. DOI: 10.1007/978-1-4471-5128-9  0.01
2013 Chen C. An overview of what we are about International Surgery. 98. PMID 23971785 DOI: 10.9738/0020-8868-98.3.i  0.01
2013 Chen C. Editorial review board International Surgery. 98. PMID 23701158 DOI: 10.9738/0020-8868-98.2.i  0.01
2013 Chen C. Goals for 2013 International Surgery. 98. PMID 23438284 DOI: 10.9738/0020-8868-98.1.000  0.01
2013 Chen C. Empathy in language learning and its inspiration to the development of intercultural communicative competence Theory and Practice in Language Studies. 3: 2267-2273. DOI: 10.4304/tpls.3.12.2267-2273  0.01
2012 Chen C. 21st century technology and online publishing International Surgery. 97. PMID 23102087 DOI: 10.9738/0020-8868-97.2.i  0.01
2012 Chen C. Implementation of electronic publishing and distribution International Surgery. 97. DOI: 10.9738/0020-8868-97.1.fmi  0.01
2011 Chen C. The importance of peer review and constant improvement International Surgery. 96. PMID 22026297 DOI: 10.9738/0020-8868-96.2.i  0.01
2011 Chen C. Moving forward International Surgery. 96. DOI: 10.9738/0020-8868-96.4.i  0.01
2011 Chen C. Electronic distribution of International Surgery International Surgery. 96.  0.01
2009 Chen C. Preface China's Integration With the Global Economy: Wto Accession, Foreign Direct Investment and International Trade. DOI: 10.1007/978-3-642-54812-3  0.01
2009 Chen C. China's economy after WTO accession: An overview China's Integration With the Global Economy: Wto Accession, Foreign Direct Investment and International Trade. 1-16.  0.01
2009 Chen C. Getting saved in America: Taiwanese immigration and religious experience Getting Saved in America: Taiwanese Immigration and Religious Experience.  0.01
2009 Chen C. Preface China's Integration With the Global Economy: Wto Accession, Foreign Direct Investment and International Trade.  0.01
2008 Chen C. Obesity in China. Foreword Obesity Reviews : An Official Journal of the International Association For the Study of Obesity. 9: 1. PMID 18307690 DOI: 10.1111/j.1467-789X.2007.00429.x  0.01
2008 Chen C. Chinese Americans and American society Chinese Studies in History. 41: 3-22. DOI: 10.2753/CSH0009-4633410301  0.01
2008 Chen C. " True Buddhism is not Chinese": Taiwanese immigrants defining Buddhist identity in the United States Religion and the Social Order. 15: 145-161.  0.01
2007 Chen C. Institutional barriers to private participation in infrastructure: The case of electronic toll collection in Taiwan Association of Researchers in Construction Management, Arcom 2007 - Proceedings of the 23rd Annual Conference. 2: 673-682.  0.01
2006 Chen C. The Iron Core Company Cim Magazine. 1: 16-23.  0.01
2006 Chen C. Quadra mining - Dressed for success Cim Magazine. 1.  0.01
2006 Chen C. Coal and oil sands: Hometown flavour of the oil sands Cim Magazine. 1.  0.01
2006 Chen C. Coal and oil sands: East coast coal still making history Cim Magazine. 1.  0.01
2006 Chen C. Coal and oil sands: Reinventing an industry at Western Canadian Coal Cim Magazine. 1.  0.01
2005 Chen C. Developing ties for quick project construction Cim Bulletin. 98: 22-23.  0.01
2005 Chen C. The Jericho Diamond Project: Canada's next diamond producer ramping up Cim Bulletin. 98: 48-50.  0.01
2003 Chen C. Superconvergence for rectangular serendipity finite elements Science in China, Series a: Mathematics, Physics, Astronomy. 46: 1. DOI: 10.1360/03ys9001  0.01
2003 Chen C. The roots of illiberal nationalism in Romania: A historical institutionalist analysis of the Leninist legacy East European Politics and Societies. 17: 166-201+349. DOI: 10.1177/0888325403017002002  0.01
2002 Chen C. Generation of even-number-atom Greenberger-Horne-Zerlinger states Guangzi Xuebao/Acta Photonica Sinica. 31: 799.  0.01
1993 Chen C. Quality of medical care and quality assurance Annals of the Academy of Medicine Singapore. 22: 127-128. PMID 8363323  0.01
1993 Chen C. Reply Journal of the American College of Cardiology. 22: 1554-1555. DOI: 10.1016/0735-1097(93)90577-N  0.01
1991 Chen C. A preliminary report on percutaneous balloon valvuloplasty by domestic balloon catheter Chinese Journal of Cardiology. 19: 151-152. PMID 1914855  0.01
1966 Chen C. Calcareous zooplankton in the Scotia Sea and Drake Passage Nature. 212: 678-681. DOI: 10.1038/212678a0  0.01
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