| Year |
Citation |
Score |
| 2020 |
Jayakar SS, Chiara DC, Zhou X, Wu B, Bruzik KS, Miller KW, Cohen JB. Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABA) receptors. The Journal of Biological Chemistry. PMID 32540960 DOI: 10.1074/Jbc.Ra120.013452 |
0.348 |
|
| 2017 |
Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. European Journal of Medicinal Chemistry. 136: 334-347. PMID 28505538 DOI: 10.1016/J.Ejmech.2017.04.043 |
0.313 |
|
| 2016 |
Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type-A Receptors (GABAAR). The Journal of Biological Chemistry. PMID 27821594 DOI: 10.1074/Jbc.M116.753335 |
0.316 |
|
| 2016 |
Chiara DC, Savechenkov PY, Zhou X, Desai R, Stern AT, Zhang Y, Forman SA, Bruzik KS, Miller KW, Cohen JB. Interactions of a Photoreactive Steroid Anesthetic (F4N3-Alphaxalone) with Human α1β3γ2 GABA-A Receptors Biophysical Journal. 110: 455a. DOI: 10.1016/J.Bpj.2015.11.2438 |
0.337 |
|
| 2015 |
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. Contrasting actions of a convulsant barbiturate and its anti-convulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects. The Journal of Physiology. PMID 26378885 DOI: 10.1113/Jp270971 |
0.34 |
|
| 2015 |
Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface. The Journal of Biological Chemistry. PMID 26229099 DOI: 10.1074/Jbc.M115.672006 |
0.339 |
|
| 2014 |
Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. The Journal of Biological Chemistry. 289: 27456-68. PMID 25086038 DOI: 10.1074/Jbc.M114.581728 |
0.324 |
|
| 2014 |
Hamouda AK, Stewart DS, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB. Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate. Molecular Pharmacology. 85: 735-46. PMID 24563544 DOI: 10.1124/Mol.113.090985 |
0.312 |
|
| 2013 |
Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor. The Journal of Biological Chemistry. 288: 19343-57. PMID 23677991 DOI: 10.1074/Jbc.M113.479725 |
0.325 |
|
| 2012 |
Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW. Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*. Biophysical Journal. 103: 2331-40. PMID 23283232 DOI: 10.1016/J.Bpj.2012.10.034 |
0.339 |
|
| 2012 |
Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. Journal of Medicinal Chemistry. 55: 6554-65. PMID 22734650 DOI: 10.1021/Jm300631E |
0.322 |
|
| 2011 |
Kruszynski R, Czubacka E, Trzesowska-Kruszynska A, Bartczak TJ, Bruzik KS, Knopik P, Kudzin Z, Stec WJ, Wolf WM. Conformation of Sterically Hindered 4-Methyl-2-oxo-2-trityl-1,3,2-dioxaphosphorinane in the Solid State and the Solution Journal of Chemical Crystallography. 41: 908-918. DOI: 10.1007/S10870-011-0102-Y |
0.323 |
|
| 2010 |
Bai C, Zhao L, Tsai MD, Bruzik KS. Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus. Journal of the American Chemical Society. 132: 1210-1. PMID 20052980 DOI: 10.1021/Ja908285H |
0.756 |
|
| 2010 |
Mihai C, Yue X, Zhao L, Kravchuk A, Tsai MD, Bruzik KS. Nonhydrolyzable analogs of phosphatidylinositol as ligands of phospholipases C New Journal of Chemistry. 34: 925-933. DOI: 10.1039/B9Nj00629J |
0.766 |
|
| 2010 |
MIHAI C, MATAKA J, RIDDLE S, TSAI M, BRUZIK KS. ChemInform Abstract: Synthesis of Enantiomerically Pure Phosphorothiolate Assay Substrate for Phosphatidylinositol-Specific Phospholipase C. Cheminform. 28: no-no. DOI: 10.1002/chin.199739247 |
0.744 |
|
| 2009 |
Bai C, Zhao L, Rebecchi M, Tsai MD, Bruzik KS. Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus. Journal of the American Chemical Society. 131: 8362-3. PMID 19492832 DOI: 10.1021/Ja902326U |
0.742 |
|
| 2007 |
Liu Y, Mihai C, Kubiak RJ, Rebecchi M, Bruzik KS. Phosphorothiolate analogues of phosphatidylinositols as assay substrates for phospholipase C. Chembiochem : a European Journal of Chemical Biology. 8: 1430-9. PMID 17659518 DOI: 10.1002/Cbic.200700061 |
0.763 |
|
| 2004 |
Stahelin RV, Ananthanarayanan B, Blatner NR, Singh S, Bruzik KS, Murray D, Cho W. Mechanism of membrane binding of the phospholipase D1 PX domain. The Journal of Biological Chemistry. 279: 54918-26. PMID 15475361 DOI: 10.1074/Jbc.M407798200 |
0.303 |
|
| 2003 |
Liu Y, Bruzik KS, Ananthanarayanan B, Cho W. New aspects of formation of 1,2-cyclic phosphates by phospholipase C-delta1. Bioorganic & Medicinal Chemistry. 11: 2471-5. PMID 12735994 DOI: 10.1016/S0968-0896(03)00150-0 |
0.393 |
|
| 2003 |
Mihai C, Kravchuk AV, Tsai MD, Bruzik KS. Application of Brønsted-type LFER in the study of the phospholipase C mechanism. Journal of the American Chemical Society. 125: 3236-42. PMID 12630878 DOI: 10.1021/Ja029362S |
0.768 |
|
| 2003 |
Kravchuk AV, Zhao L, Bruzik KS, Tsai MD. Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity. Biochemistry. 42: 2422-30. PMID 12600209 DOI: 10.1021/Bi0271953 |
0.533 |
|
| 2003 |
Kubiak RJ, Bruzik KS. Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols. The Journal of Organic Chemistry. 68: 960-8. PMID 12558421 DOI: 10.1021/Jo0206418 |
0.353 |
|
| 2003 |
Zhao L, Liu Y, Bruzik KS, Tsai MD. A novel calcium-dependent bacterial phosphatidylinositol-specific phospholipase C displaying unprecedented magnitudes of thio effect, inverse thio effect, and stereoselectivity. Journal of the American Chemical Society. 125: 22-3. PMID 12515492 DOI: 10.1021/Ja029019N |
0.587 |
|
| 2001 |
Kravchuk AV, Zhao L, Kubiak RJ, Bruzik KS, Tsai MD. Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effects. Biochemistry. 40: 5433-9. PMID 11331007 DOI: 10.1021/Bi002372Q |
0.606 |
|
| 2001 |
Kubiak RJ, Yue X, Hondal RJ, Mihai C, Tsai MD, Bruzik KS. Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond. Biochemistry. 40: 5422-32. PMID 11331006 DOI: 10.1021/Bi002371Y |
0.776 |
|
| 2000 |
Hengge AC, Bruzik KS, Tobin AE, Cleland WW, Tsai MD. Kinetic Isotope Effects and Stereochemical Studies on a Ribonuclease Model: Hydrolysis Reactions of Uridine 3'-Nitrophenyl Phosphate. Bioorganic Chemistry. 28: 119-133. PMID 10915550 DOI: 10.1006/Bioo.2000.1170 |
0.513 |
|
| 1999 |
Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, Shears SB. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. The Journal of Biological Chemistry. 274: 18973-80. PMID 10383396 DOI: 10.1074/Jbc.274.27.18973 |
0.324 |
|
| 1999 |
Kubiak RJ, Hondal RJ, Yue X, Tsai MD, Bruzik KS. Identification of a novel catalytic triad with dual functions in enzymatic cleavage of the P-O bond Journal of the American Chemical Society. 121: 488-489. DOI: 10.1021/Ja9834677 |
0.435 |
|
| 1999 |
Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Bruzik KS, Tsai MD. Mechanism of phosphatidylinositol-specific phospholipase C revealed by protein engineering and phosphorothioate analogs of phosphatidylinositol Acs Symposium Series. 718: 109-120. |
0.312 |
|
| 1998 |
Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Yue X, Bruzik KS, Tsai MD. Mechanism of phosphatidylinositol-specific phospholipase C: A unified view of the mechanism of catalysis Biochemistry. 37: 4568-4580. PMID 9521777 DOI: 10.1021/Bi972646I |
0.571 |
|
| 1998 |
Solomons KR, Freeman S, Schwalbe CH, Shears SB, Nelson DJ, Xie W, Bruzik KS, Kaetzel MA. Synthesis of d-1,2-dideoxy-1,2-difluoro-myo-inositol 3,4,5,6-tetrakisphosphate and its enantiomer as analogues of myo-inositol 3,4,5,6-tetrakisphosphate Carbohydrate Research. 309: 337-343. DOI: 10.1016/S0008-6215(98)00146-3 |
0.334 |
|
| 1997 |
Hondal RJ, Riddle SR, Kravchuk AV, Zhao Z, Liao H, Bruzik KS, Tsai MD. Phosphatidylinositol-specific phospholipase C: Kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol Biochemistry. 36: 6633-6642. PMID 9184143 DOI: 10.1021/Bi962866G |
0.604 |
|
| 1997 |
Bruzik KS, Nyholm PG. NMR study of the conformation of galactocerebroside in bilayers and solution: galactose reorientation during the metastable-stable gel transition. Biochemistry. 36: 566-75. PMID 9012672 DOI: 10.1021/Bi962204R |
0.359 |
|
| 1997 |
Tan Z, Bruzik KS, Shears SB. Properties of the inositol 3,4,5,6-tetrakisphosphate 1-kinase purified from rat liver. Regulation of enzyme activity by inositol 1,3,4-trisphosphate. The Journal of Biological Chemistry. 272: 2285-90. PMID 8999935 DOI: 10.1074/Jbc.272.4.2285 |
0.376 |
|
| 1997 |
Hondal RJ, Zhao Z, Riddle SR, Kravchuk AV, Liao H, Bruzik KS, Tsai MD. Phosphatidylinositol-specific phospholipase C. 3. Elucidation of the catalytic mechanism and comparison with ribonuclease A Journal of the American Chemical Society. 119: 9933-9934. DOI: 10.1021/Ja9714402 |
0.548 |
|
| 1997 |
Hondal RJ, Bruzik KS, Zhao Z, Tsai MD. Mechanism of phosphatidylinositol-phospholipase C. 2. Reversal of a thio effect by site-directed mutagenesis [17] Journal of the American Chemical Society. 119: 5477-5478. DOI: 10.1021/Ja964217Y |
0.537 |
|
| 1997 |
Mihai C, Mataka J, Riddle S, Tsai MD, Bruzik KS. Synthesis of enantiomerically pure phosphorothiolate assay substrate for phosphatidylinositol-specific phospholipase C Bioorganic and Medicinal Chemistry Letters. 7: 1235-1238. DOI: 10.1016/S0960-894X(97)00197-2 |
0.729 |
|
| 1997 |
Kubiak RJ, Bruzik KS. SYNTHESIS OF PHOSPHOROTHIOATE ANALOGS OF PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE Bioorganic & Medicinal Chemistry Letters. 7: 1231-1234. DOI: 10.1016/S0960-894X(97)00196-0 |
0.322 |
|
| 1996 |
Zhiwen G, Bruzik K. Enzymatic Synthesis of Inositol Phosphodiesters Using Phosphatidylinositol-Specific Phospholipase C Phosphorus, Sulfur, and Silicon and the Related Elements. 111: 69-69. DOI: 10.1080/10426509608054698 |
0.399 |
|
| 1996 |
Bhamare N, Wang Y, Tsai MD, Bruzik KS. Design, Synthesis And Biochemical Applications Of Analogs Of Phosphatidylinositol Phosphorus Sulfur and Silicon and the Related Elements. 109: 317-320. DOI: 10.1080/10426509608046262 |
0.38 |
|
| 1996 |
Bruzik KS, Guan Z, Riddle S, Tsai M. Synthesis of Inositol Phosphodiesters by Phospholipase C-Catalyzed Transesterification† Journal of the American Chemical Society. 118: 7679-7688. DOI: 10.1021/Ja9616084 |
0.559 |
|
| 1995 |
Bruzik KS, Kubiak RJ. General synthesis of phosphatidylinositol 3-phosphates Tetrahedron Letters. 36: 2415-2418. DOI: 10.1016/0040-4039(95)00317-6 |
0.329 |
|
| 1994 |
Bruzik KS, Hakeem AA, Tsai MD. Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C? Biochemistry. 33: 8367-8374. PMID 8031771 DOI: 10.1021/Bi00193A026 |
0.529 |
|
| 1994 |
Bruzik KS, Tsai MD. Toward the mechanism of phosphoinositide-specific phospholipases C. Bioorganic & Medicinal Chemistry. 2: 49-72. PMID 7922124 DOI: 10.1016/S0968-0896(00)82002-7 |
0.516 |
|
| 1992 |
Bruzik KS, Morocho AM, Jhon DY, Rhee SG, Tsai MD. Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C. Biochemistry. 31: 5183-93. PMID 1318746 DOI: 10.1021/Bi00137A014 |
0.513 |
|
| 1992 |
Bruzik KS, Tsai MD. Efficient and systematic syntheses of enantiomerically pure and regiospecifically protected myo-inositols Journal of the American Chemical Society. 114: 6361-6374. DOI: 10.1021/Ja00042A011 |
0.368 |
|
| 1992 |
Bruzik KS, Myers J, Tsai M. Practical synthesis of enantiomerically pure myo-inositol derivatives Tetrahedron Letters. 33: 1009-1012. DOI: 10.1016/S0040-4039(00)91846-X |
0.33 |
|
| 1992 |
Pietrusiewicz K, Salamończyk GM, Bruzik KS, Wieczorek W. The synthesis of homochiral inositol phosphates from myo-inositol Tetrahedron. 48: 5523-5542. DOI: 10.1016/S0040-4020(01)88305-8 |
0.362 |
|
| 1991 |
Bruzik KS, Tsai MD. Phospholipase stereospecificity at phosphorus. Methods in Enzymology. 197: 258-69. PMID 1646930 DOI: 10.1016/0076-6879(91)97151-N |
0.488 |
|
| 1990 |
Bruzik KS, Grajkowski A, Lesnikowski ZJ, Salamonczyk GM, Stec WJ. Conformation of Diastereomers of Adenosine Cyclic 3′, 5′-Phosphorothioate Nucleosides and Nucleotides. 9: 827-836. DOI: 10.1080/15257779008043148 |
0.318 |
|
| 1990 |
Bruzik KS, Salamończyk GM, Soboń B. From Molecular Conformation to Phospholipid Bilayer Organization Phosphorus, Sulfur, and Silicon and the Related Elements. 51: 39-42. DOI: 10.1080/10426509008040677 |
0.308 |
|
| 1990 |
M.Salamonczyk G, S.Bruzik K. The synthesis of diastereomers of phosphorothioate analogue of dipalmitoylphosphatidylinositol Tetrahedron Letters. 31: 2015-2016. DOI: 10.1016/S0040-4039(00)88903-0 |
0.307 |
|
| 1989 |
Antkowiak R, Antkowiak WZ, Bruzik K. The structure of sultone formed in reychler's reaction Tetrahedron. 45: 7515-7522. DOI: 10.1016/S0040-4020(01)89214-0 |
0.308 |
|
| 1989 |
Bruzik KS, Salamończyk GM. Synthesis of the enantiomeric 1,4,5,6-tetra-O-benzyl-myo inositols Carbohydrate Research. 195: 67-73. DOI: 10.1016/0008-6215(89)85089-X |
0.355 |
|
| 1988 |
Bruzik KS. Conformation of the polar headgroup of sphingomyelin and its analogues. Biochimica Et Biophysica Acta. 939: 315-26. PMID 3355820 DOI: 10.1016/0005-2736(88)90076-4 |
0.358 |
|
| 1988 |
Bruzik KS, Stec WJ. ALKOXYPHOSPHONIUM SALT INTERMEDIATES IN THE THIONO-THIOLO REARRANGEMENT OF PHOSPHYLTHIONATES IN PROTIC ACID MEDIA Phosphorous and Sulfur and the Related Elements. 35: 229-240. DOI: 10.1080/03086648808074326 |
0.371 |
|
| 1988 |
Bruzik KS. Synthesis and spectral properties of chemically and stereochemically homogeneous sphingomyelin and its analogues Journal of the Chemical Society-Perkin Transactions 1. 423-431. DOI: 10.1039/P19880000423 |
0.385 |
|
| 1987 |
Bruzik KS, Tsai MD. A calorimetric study of the thermotropic behavior of pure sphingomyelin diastereomers. Biochemistry. 26: 5364-8. PMID 3676257 DOI: 10.1021/Bi00391A022 |
0.504 |
|
| 1985 |
Tsai TC, Hart J, Jiang RT, Bruzik K, Tsai MD. Phospholipids chiral at phosphorus. Use of chiral thiophosphatidylcholine to study the metal-binding properties of bee venom phospholipase A2. Biochemistry. 24: 3180-8. PMID 3839681 DOI: 10.1021/Bi00334A016 |
0.5 |
|
| 1984 |
Bruzik K, Tsai MD. Phospholipids chiral at phosphorus. Synthesis of chiral phosphatidylcholine and stereochemistry of phospholipase D. Biochemistry. 23: 1656-61. PMID 6722117 DOI: 10.1021/Bi00303A012 |
0.347 |
|
| 1983 |
Bruzik K, Jiang RT, Tsai MD. Phospholipids chiral at phosphorus. Preparation and spectral properties of chiral thiophospholipids. Biochemistry. 22: 2478-86. PMID 6688028 DOI: 10.1021/Bi00279A026 |
0.486 |
|
| 1983 |
Bruzik KS, Jiang R, Tsai M. Phospholipids chiral at phosphorus. synthesis, absolute configurations and applications Phosphorus and Sulfur and the Related Elements. 18: 369-372. DOI: 10.1080/03086648308076042 |
0.48 |
|
| 1982 |
Bruzik K, Tsai MD. Phospholipids chiral at phosphorus. 1. Stereochemistry of transphosphatidylation catalyzed by phospholipase D Journal of the American Chemical Society. 104: 863-865. DOI: 10.1002/Chin.198221245 |
0.311 |
|
| 1979 |
Bruzik K, Stec WJ. Stereochemistry of thiono-thiolo rearrangement of phosphorothioic esters. 2 The Journal of Organic Chemistry. 44: 4488-4492. DOI: 10.1021/Jo00393A005 |
0.326 |
|
| 1976 |
Stec WJ, Uzanski B, Bruzik K, Michalski J. Correction. Protic Acid Catalyzed Thiono-Thiolo Rearrangements of Phosphorus Esters. The Journal of Organic Chemistry. 41: 4051-4052. DOI: 10.1021/Jo00887A616 |
0.302 |
|
| 1976 |
Stec WJ, Uznanski B, Bruzik K, Michalski J. Protic acid catalyzed thiono-thiolo rearrangements of phosphorus esters The Journal of Organic Chemistry. 41: 1291-1293. DOI: 10.1021/Jo00869A058 |
0.307 |
|
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