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Shengyun Fang - Publications

Affiliations: 
Marine-Estuarine-Environmental Sciences University of Maryland, College Park, College Park, MD 
Area:
General Biology, Molecular Biology, Biochemistry
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu J, Wu Z, Han D, Wei C, Liang Y, Jiang T, Chen L, Sha M, Cao Y, Huang F, Geng X, Yu J, Shen Y, Wang H, Feng L, ... ... Fang S, et al. MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition. Hepatology (Baltimore, Md.). PMID 31469428 DOI: 10.1002/Hep.30917  0.335
2019 Rothan HA, Zhong Y, Sanborn MA, Teoh TC, Ruan J, Yusof R, Hang J, Henderson MJ, Fang S. Small molecule grp94 inhibitors with antiviral activity against Dengue and Zika virus. Antiviral Research. 104590. PMID 31421166 DOI: 10.1016/J.Antiviral.2019.104590  0.304
2019 Ruan J, Rothan HA, Zhong Y, Yan W, Henderson MJ, Chen F, Fang S. A small molecule inhibitor of ER-to-cytosol protein dislocation exhibits anti-dengue and anti-Zika virus activity. Scientific Reports. 9: 10901. PMID 31358863 DOI: 10.1038/S41598-019-47532-7  0.365
2017 Zhong Y, Wang J, Henderson MJ, Yang P, Hagen BM, Siddique T, Vogel BE, Deng HX, Fang S. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. Elife. 6. PMID 28463106 DOI: 10.7554/Elife.23759  0.313
2017 Bao D, Cheng C, Lan X, Xing R, Chen Z, Zhao H, Sun J, Wang Y, Niu C, Zhang B, Fang S. Regulation of p53wt glioma cell proliferation by androgen receptor-mediated inhibition of small VCP/p97-interacting protein expression. Oncotarget. 8: 23142-23154. PMID 28423563 DOI: 10.18632/Oncotarget.15509  0.367
2017 Feng L, Zhang J, Zhu N, Ding Q, Zhang X, Yu J, Qiang W, Zhang Z, Ma Y, Huang D, Shen Y, Fang S, Yu Y, Wang H, Shen Y. Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy. 0. PMID 28121484 DOI: 10.1080/15548627.2017.1280207  0.393
2016 Wu T, Chen W, Zhong Y, Hou X, Fang S, Liu CY, Wang G, Yu T, Huang YY, Ouyang X, Li HQ, Cui L, Yang Y. Nuclear export of ubiquitinated proteins determines the sensitivity of colorectal cancer to proteasome inhibitor. Molecular Cancer Therapeutics. PMID 27903750 DOI: 10.1158/1535-7163.Mct-16-0553  0.375
2016 Chen Q, Zhong Y, Wu Y, Liu L, Wang P, Liu R, Cui F, Li Q, Yang X, Fang S, Xie Q. HRD1-mediated ERAD tuning of ER-bound E2 is conserved between plants and mammals. Nature Plants. 2: 16094. PMID 27322605 DOI: 10.1038/Nplants.2016.94  0.383
2016 Liu J, Tao X, Zhang J, Wang P, Sha M, Ma Y, Geng X, Feng L, Shen Y, Yu Y, Wang S, Fang S, Shen Y. Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation. Oncotarget. PMID 26993772 DOI: 10.18632/Oncotarget.8066  0.327
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Fang S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.334
2015 Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, Fang S. Data in support of DPF2 regulates OCT4 protein level and nuclear distribution. Data in Brief. 5: 599-604. PMID 26958616 DOI: 10.1016/J.Dib.2015.10.010  0.362
2015 Liu J, Zhou C, Tao X, Feng L, Wang X, Chen L, Li C, Huang D, Fang S, Shen Y. ER stress-inducible protein MANF selectively expresses in human spleen. Human Immunology. PMID 26429332 DOI: 10.1016/J.Humimm.2015.09.043  0.348
2015 Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, Fang S. DPF2 regulates OCT4 protein level and nuclear distribution. Biochimica Et Biophysica Acta. PMID 26417682 DOI: 10.1016/J.Bbamcr.2015.09.029  0.408
2015 Li J, Chen Z, Gao LY, Colorni A, Ucko M, Fang S, Du SJ. A transgenic zebrafish model for monitoring xbp1 splicing and endoplasmic reticulum stress in vivo. Mechanisms of Development. PMID 25892297 DOI: 10.1016/J.Mod.2015.04.001  0.352
2015 Zhong Y, Shen H, Wang Y, Yang Y, Yang P, Fang S. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Biochemical and Biophysical Research Communications. 458: 424-8. PMID 25660456 DOI: 10.1016/J.Bbrc.2015.01.133  0.37
2015 Chen L, Feng L, Wang X, Du J, Chen Y, Yang W, Zhou C, Cheng L, Shen Y, Fang S, Li J, Shen Y. Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Scientific Reports. 5: 8133. PMID 25640174 DOI: 10.1038/Srep08133  0.373
2014 Chen Z, Ballar P, Fu Y, Luo J, Du S, Fang S. The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 41: 357-68. PMID 25064675 DOI: 10.1016/J.Jgg.2014.05.005  0.393
2014 Yang W, Shen Y, Chen Y, Chen L, Wang L, Wang H, Xu S, Fang S, Fu Y, Yu Y, Shen Y. Mesencephalic astrocyte-derived neurotrophic factor prevents neuron loss via inhibiting ischemia-induced apoptosis. Journal of the Neurological Sciences. 344: 129-38. PMID 25001514 DOI: 10.1016/J.Jns.2014.06.042  0.312
2013 Chen Z, Zhong Y, Wang Y, Xu S, Liu Z, Baskakov IV, Monteiro MJ, Karbowski M, Shen Y, Fang S. Ubiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cells. Plos One. 8: e73482. PMID 24039955 DOI: 10.1371/Journal.Pone.0073482  0.337
2012 Shen Y, Sun A, Wang Y, Cha D, Wang H, Wang F, Feng L, Fang S, Shen Y. Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation. Journal of Neuroinflammation. 9: 254. PMID 23173607 DOI: 10.1186/1742-2094-9-254  0.356
2012 Chen Z, Du S, Fang S. gp78: a multifaceted ubiquitin ligase that integrates a unique protein degradation pathway from the endoplasmic reticulum. Current Protein & Peptide Science. 13: 414-24. PMID 22812524 DOI: 10.2174/138920312802430590  0.398
2012 Zhong Y, Fang S. Live cell imaging of protein dislocation from the endoplasmic reticulum. The Journal of Biological Chemistry. 287: 28057-66. PMID 22722934 DOI: 10.1074/Jbc.M112.381798  0.399
2011 Wang Y, Ballar P, Zhong Y, Zhang X, Liu C, Zhang YJ, Monteiro MJ, Li J, Fang S. SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy. Plos One. 6: e24478. PMID 21909394 DOI: 10.1371/Journal.Pone.0024478  0.383
2011 Zhong Y, Wang Y, Yang H, Ballar P, Lee JG, Ye Y, Monteiro MJ, Fang S. Importin beta interacts with the endoplasmic reticulum-associated degradation machinery and promotes ubiquitination and degradation of mutant alpha1-antitrypsin. The Journal of Biological Chemistry. 286: 33921-30. PMID 21832065 DOI: 10.1074/Jbc.M111.272906  0.398
2011 Ugolino J, Fang S, Kubisch C, Monteiro MJ. Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death. Human Molecular Genetics. 20: 3565-77. PMID 21665991 DOI: 10.1093/Hmg/Ddr274  0.425
2011 Ke Z, Wang X, Liu Y, Fan Z, Chen G, Xu M, Bower KA, Frank JA, Li M, Fang S, Shi X, Luo J. Ethanol induces endoplasmic reticulum stress in the developing brain. Alcoholism, Clinical and Experimental Research. 35: 1574-83. PMID 21599712 DOI: 10.1111/J.1530-0277.2011.01503.X  0.319
2011 Dong G, Ferguson JM, Duling AJ, Nicholas RG, Zhang D, Rezvani K, Fang S, Monteiro MJ, Li S, Li XJ, Wang H. Modeling pathogenesis of Huntington's disease with inducible neuroprogenitor cells. Cellular and Molecular Neurobiology. 31: 737-47. PMID 21452052 DOI: 10.1007/S10571-011-9679-0  0.351
2011 Xu S, Peng G, Wang Y, Fang S, Karbowski M. The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Molecular Biology of the Cell. 22: 291-300. PMID 21118995 DOI: 10.1091/Mbc.E10-09-0748  0.373
2011 Wang H, Li Q, Shen Y, Sun A, Zhu X, Fang S, Shen Y. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility. Molecular and Cellular Biochemistry. 346: 137-45. PMID 20886262 DOI: 10.1007/S11010-010-0600-9  0.392
2010 Airavaara M, Chiocco MJ, Howard DB, Zuchowski KL, Peränen J, Liu C, Fang S, Hoffer BJ, Wang Y, Harvey BK. Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury. Experimental Neurology. 225: 104-13. PMID 20685313 DOI: 10.1016/J.Expneurol.2010.05.020  0.313
2010 Jiang H, Jans R, Xu W, Rorke EA, Lin CY, Chen YW, Fang S, Zhong Y, Eckert RL. Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis. The Journal of Biological Chemistry. 285: 31634-46. PMID 20663883 DOI: 10.1074/Jbc.M110.128645  0.332
2010 Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, Ugolino J, Fang S, Cuervo AM, Nixon RA, Monteiro MJ. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Human Molecular Genetics. 19: 3219-32. PMID 20529957 DOI: 10.1093/Hmg/Ddq231  0.415
2010 Yang H, Liu C, Zhong Y, Luo S, Monteiro MJ, Fang S. Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. Plos One. 5: e8905. PMID 20126661 DOI: 10.1371/Journal.Pone.0008905  0.398
2010 Ballar P, Ors AU, Yang H, Fang S. Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1. The International Journal of Biochemistry & Cell Biology. 42: 167-73. PMID 19828134 DOI: 10.1016/J.Biocel.2009.10.005  0.375
2010 Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, Zhang JJ, Shen YJ, Wang HP, Fang S, Shen YX. Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 79-91. PMID 19773801 DOI: 10.1038/Jcbfm.2009.181  0.325
2009 Lim PJ, Danner R, Liang J, Doong H, Harman C, Srinivasan D, Rothenberg C, Wang H, Ye Y, Fang S, Monteiro MJ. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. The Journal of Cell Biology. 187: 201-17. PMID 19822669 DOI: 10.1083/Jcb.200903024  0.408
2009 Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F, Guo Z, Chen H, Li W, Chen H, Kong X, Melamed J, Fang S, Xiao Z, Veenstra TD, et al. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 15: 270-82. PMID 19345326 DOI: 10.1016/J.Ccr.2009.02.021  0.311
2008 Ballar P, Fang S. Regulation of ER-associated degradation via p97/VCP-interacting motif. Biochemical Society Transactions. 36: 818-22. PMID 18793143 DOI: 10.1042/Bst0360818  0.394
2008 Apostolou A, Shen Y, Liang Y, Luo J, Fang S. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. Experimental Cell Research. 314: 2454-67. PMID 18561914 DOI: 10.1016/J.Yexcr.2008.05.001  0.416
2007 Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S. Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. The Journal of Biological Chemistry. 282: 33908-14. PMID 17872946 DOI: 10.1074/Jbc.M704446200  0.405
2007 Shen Y, Ballar P, Apostolou A, Doong H, Fang S. ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates. Biochemical and Biophysical Research Communications. 352: 919-24. PMID 17157811 DOI: 10.1016/J.Bbrc.2006.11.121  0.38
2007 Yang H, Zhong X, Ballar P, Luo S, Shen Y, Rubinsztein DC, Monteiro MJ, Fang S. Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. Experimental Cell Research. 313: 538-50. PMID 17141218 DOI: 10.1016/J.Yexcr.2006.10.031  0.453
2006 Ballar P, Shen Y, Yang H, Fang S. The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation. The Journal of Biological Chemistry. 281: 35359-68. PMID 16987818 DOI: 10.1074/Jbc.M603355200  0.372
2006 Shen Y, Ballar P, Fang S. Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. Biochemical and Biophysical Research Communications. 349: 1285-93. PMID 16979136 DOI: 10.1016/J.Bbrc.2006.08.173  0.428
2006 Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon RA, Monteiro MJ. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. Journal of Cell Science. 119: 4011-24. PMID 16968747 DOI: 10.1242/Jcs.03163  0.428
2006 Vij N, Fang S, Zeitlin PL. Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. The Journal of Biological Chemistry. 281: 17369-78. PMID 16621797 DOI: 10.1074/Jbc.M600509200  0.417
2006 Vij N, Fang S, Zeitlin PL. 717. VCP Short Hairpin RNA Rescues ΔF508- CFTR and Suppresses IL8 Levels: Therapeutic Implications in Cystic Fibrosis Molecular Therapy. 13: S276-S277. DOI: 10.1016/J.Ymthe.2006.08.796  0.34
2004 Zhong X, Shen Y, Ballar P, Apostolou A, Agami R, Fang S. AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. The Journal of Biological Chemistry. 279: 45676-84. PMID 15331598 DOI: 10.1074/Jbc.M409034200  0.42
2004 Fang S, Weissman AM. A field guide to ubiquitylation. Cellular and Molecular Life Sciences. 61: 1546-1561. PMID 15224180 DOI: 10.1007/S00018-004-4129-5  0.364
2004 Chen G, Bower KA, Ma C, Fang S, Thiele CJ, Luo J. Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1162-4. PMID 15132987 DOI: 10.1096/Fj.04-1551Fje  0.356
2003 Magnifico A, Ettenberg S, Yang C, Mariano J, Tiwari S, Fang S, Lipkowitz S, Weissman AM. WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. The Journal of Biological Chemistry. 278: 43169-77. PMID 12907674 DOI: 10.1074/Jbc.M308009200  0.355
2003 Doong H, Rizzo K, Fang S, Kulpa V, Weissman AM, Kohn EC. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. The Journal of Biological Chemistry. 278: 28490-500. PMID 12750378 DOI: 10.1074/Jbc.M209682200  0.371
2003 Liang JS, Kim T, Fang S, Yamaguchi J, Weissman AM, Fisher EA, Ginsberg HN. Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. The Journal of Biological Chemistry. 278: 23984-8. PMID 12670940 DOI: 10.1074/Jbc.M302683200  0.424
2003 Fang S, Lorick KL, Jensen JP, Weissman AM. RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Seminars in Cancer Biology. 13: 5-14. PMID 12507552 DOI: 10.1016/S1044-579X(02)00095-0  0.355
2002 Xie Q, Guo HS, Dallman G, Fang S, Weissman AM, Chua NH. SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature. 419: 167-70. PMID 12226665 DOI: 10.1038/Nature00998  0.335
2001 Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM. The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum Proceedings of the National Academy of Sciences of the United States of America. 98: 14422-14427. PMID 11724934 DOI: 10.1073/Pnas.251401598  0.365
2000 Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science. 288: 874-877. PMID 10797013 DOI: 10.1126/Science.288.5467.874  0.332
2000 Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. Journal of Biological Chemistry. 275: 8945-8951. PMID 10722742 DOI: 10.1074/Jbc.275.12.8945  0.381
1999 Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination Proceedings of the National Academy of Sciences of the United States of America. 96: 11364-11369. PMID 10500182 DOI: 10.1073/Pnas.96.20.11364  0.34
1999 Sharma RV, Tan E, Fang S, Gurjar MV, Bhalla RC. NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells. The American Journal of Physiology. 276: H1450-9. PMID 10330227 DOI: 10.1152/Ajpheart.1999.276.5.H1450  0.343
1999 Fang S, Sharma RV, Bhalla RC. Enhanced recovery of injury-caused downregulation of paxillin protein by eNOS gene expression in rat carotid artery: Mechanism of NO inhibition of intimal hyperplasia Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 147-152. PMID 9888877 DOI: 10.1161/01.Atv.19.1.147  0.311
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