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Douglas E. Linn, Ph.D. - Publications

Affiliations: 
2011 Toxicology University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Molecular Biology, Oncology, Toxicology
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Barros-Silva JD, Linn DE, Steiner I, Guo G, Ali A, Pakula H, Ashton G, Peset I, Brown M, Clarke NW, Bronson RT, Yuan GC, Orkin SH, Li Z, Baena E. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports. 25: 3504-3518.e6. PMID 30566873 DOI: 10.1016/J.Celrep.2018.11.069  0.513
2018 Pakula H, Linn DE, Schmidt DR, Van Gorsel M, Vander Heiden MG, Li Z. Protocols for Studies on TMPRSS2/ERG in Prostate Cancer. Methods in Molecular Biology (Clifton, N.J.). 1786: 131-151. PMID 29786791 DOI: 10.1007/978-1-4939-7845-8_8  0.523
2016 Linn DE, Penney KL, Bronson RT, Mucci LA, Li Z. Deletion of interstitial genes between TMPRSS2 and ERG promotes prostate cancer progression. Cancer Research. PMID 26880803 DOI: 10.1158/0008-5472.CAN-15-1911  0.506
2016 Barros-Silva J, Linn D, Steiner I, Guo G, Yuan G, Orkin S, Li Z, Baena E. Proffered Paper: Exploring prostate progenitor compartment complexity as a route of targeting prostate cancer heterogeneity European Journal of Cancer. 61: S5. DOI: 10.1016/S0959-8049(16)61011-0  0.475
2015 Linn DE, Bronson RT, Li Z. Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models. Plos One. 10: e0120628. PMID 25780911 DOI: 10.1371/journal.pone.0120628  0.529
2013 Natarajan K, Xie Y, Burcu M, Linn DE, Qiu Y, Baer MR. Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication. Plos One. 8: e74653. PMID 24040307 DOI: 10.1371/Journal.Pone.0074653  0.569
2013 Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, et al. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes & Development. 27: 683-98. PMID 23512661 DOI: 10.1101/Gad.211011.112  0.512
2013 Linn D, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li W, Xu K, Chen M, Qiu Y. Abstract 4089: Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases. Cancer Research. 73: 4089-4089. DOI: 10.1158/1538-7445.Am2013-4089  0.737
2012 Linn DE, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li W, Xu K, Chen M, Qiu Y. Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases. The Journal of Biological Chemistry. 287: 22959-68. PMID 22584579 DOI: 10.1074/Jbc.M111.338350  0.74
2010 Linn DE, Yang X, Sun F, Xie Y, Chen H, Jiang R, Chen H, Chumsri S, Burger AM, Qiu Y. A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostate Cancer Cells. Genes & Cancer. 1: 908-16. PMID 21779471 DOI: 10.1177/1947601910388271  0.601
2010 Dai B, Chen H, Guo S, Yang X, Linn DE, Sun F, Li W, Guo Z, Xu K, Kim O, Kong X, Melamed J, Qiu S, Chen H, Qiu Y. Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells. Cancer Research. 70: 5587-96. PMID 20570899 DOI: 10.1158/0008-5472.Can-09-4610  0.745
2010 Xie Y, Burcu M, Linn DE, Qiu Y, Baer MR. Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression. Molecular Pharmacology. 78: 310-8. PMID 20460432 DOI: 10.1124/Mol.109.061713  0.601
2010 Linn DE, Yang X, Sun F, Xie Y, Chumsri S, Burger A, Qiu Y. Abstract 4228: A functional role of OCT4 for prostate tumor initiation Cancer Research. 70: 4228-4228. DOI: 10.1158/1538-7445.Am10-4228  0.631
2010 Guo Z, Yang X, Sun F, Linn DE, Jiang R, Chen H, Chen H, Kong X, Melamed J, Tepper CG, Kung H, Brodie AMH, Edwards J, Qiu Y. Abstract 1712: Androgen receptor splicing variants promote therapeutic resistance in prostate cancer Cancer Research. 70: 1712-1712. DOI: 10.1158/1538-7445.Am10-1712  0.731
2009 Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F, Guo Z, Chen H, Li W, Chen H, Kong X, Melamed J, Fang S, Xiao Z, Veenstra TD, et al. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 15: 270-82. PMID 19345326 DOI: 10.1016/J.Ccr.2009.02.021  0.72
2009 Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, Chen H, Kong X, Melamed J, Tepper CG, Kung HJ, Brodie AM, Edwards J, Qiu Y. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Research. 69: 2305-13. PMID 19244107 DOI: 10.1158/0008-5472.Can-08-3795  0.717
2008 Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW. EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Molecular Cancer Therapeutics. 7: 3176-86. PMID 18852121 DOI: 10.1158/1535-7163.Mct-08-0526  0.653
2008 Xie Y, Xu K, Linn DE, Yang X, Guo Z, Shimelis H, Nakanishi T, Ross DD, Chen H, Fazli L, Gleave ME, Qiu Y. The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells. The Journal of Biological Chemistry. 283: 3349-56. PMID 18056989 DOI: 10.1074/Jbc.M707773200  0.714
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