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Steven Belinsky - Publications

Affiliations: 
University of New Mexico, Albuquerque, NM, United States 
Area:
Biochemistry
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Year Citation  Score
2021 Tellez CS, Picchi MA, Juri D, Do K, Desai DH, Amin SG, Hutt JA, Filipczak PT, Belinsky SA. Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention. Clinical Epigenetics. 13: 44. PMID 33632299 DOI: 10.1186/s13148-021-01034-4  0.441
2020 Tessema M, Tassew DD, Yingling CM, Do K, Picchi MA, Wu G, Petersen H, Randell S, Lin Y, Belinsky SA, Tesfaigzi Y. Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients. Lung Cancer (Amsterdam, Netherlands). 146: 189-196. PMID 32559455 DOI: 10.1016/J.Lungcan.2020.05.017  0.361
2020 Kuehl PJ, Tellez CS, Grimes MJ, March TH, Tessema M, Revelli DA, Mallis LM, Dye WW, Sniegowski T, Badenoch A, Burke M, Dubose D, Vodak DT, Picchi MA, Belinsky SA. 5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming. British Journal of Cancer. PMID 32103148 DOI: 10.1038/S41416-020-0765-2  0.3
2019 Wang Q, Wang P, Zhang L, Tessema M, Bai L, Xu X, Li Q, Zheng X, Saxton B, Chen W, Willink R, Li Z, Zhang L, Belinsky SA, Wang X, et al. Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer. Translational Oncology. 13: 372-382. PMID 31887632 DOI: 10.1016/j.tranon.2019.11.011  0.357
2019 Teneng I, Picchi MA, Leng S, Dagucon CP, Ramalingam S, Tellez CS, Belinsky SA. DNA-PKc deficiency drives pre-malignant transformation by reducing DNA repair capacity in concert with reprogramming the epigenome in human bronchial epithelial cells. Dna Repair. 79: 1-9. PMID 31055244 DOI: 10.1016/j.dnarep.2019.04.006  0.402
2019 Filipczak PT, Leng S, Tellez CS, Do KC, Grimes MJ, Thomas CL, Walton-Filipczak SR, Picchi MA, Belinsky SA. p53-suppressed oncogene TET1 prevents cellular aging in lung cancer. Cancer Research. PMID 30622117 DOI: 10.1158/0008-5472.CAN-18-1234  0.395
2019 Kuehl P, Tellez C, Grimes M, Burke M, Badenoch A, Dubose D, Belinsky S. MA17.09 5-Azacytidine Inhaled Dry Powder Formulation Profoundly Improves Pharmacokinetics and Efficacy for Lung Cancer Therapy Journal of Thoracic Oncology. 14: S319-S320. DOI: 10.1016/J.Jtho.2019.08.643  0.389
2018 Tsoyi K, Osorio JC, Chu SG, Fernandez IE, Poli S, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO. Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness. American Journal of Respiratory Cell and Molecular Biology. PMID 30562054 DOI: 10.1165/Rcmb.2018-0118Oc  0.369
2018 Tessema M, Rossi MR, Picchi MA, Yingling CM, Lin Y, Ramalingam SS, Belinsky SA. Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers. Lung Cancer (Amsterdam, Netherlands). 123: 99-106. PMID 30089603 DOI: 10.1016/j.lungcan.2018.07.011  0.49
2018 Kuehl PJ, Grimes MJ, Dubose D, Burke M, Revelli DA, Gigliotti AP, Belinsky SA, Tessema M. Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model. Drug Delivery. 25: 1127-1136. PMID 29779406 DOI: 10.1080/10717544.2018.1469688  0.358
2018 Leng S, Diergaarde B, Picchi MA, Wilson DO, Gilliland FD, Yuan JM, Siegfried JM, Belinsky SA. Gene Promoter Hypermethylation Detected in Sputum Predicts FEV1 Decline and All-cause Mortality in Smokers. American Journal of Respiratory and Critical Care Medicine. PMID 29437466 DOI: 10.1164/Rccm.201708-1659Oc  0.38
2017 Leng S, Picchi MA, Kang H, Wu G, Filipczak PT, Juri DE, Zhang X, Gauderman WJ, Gilliland FD, Belinsky SA. Dietary nutrient intake, ethnicity, and epigenetic silencing of lung cancer genes detected in sputum in New Mexican smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 29118161 DOI: 10.1158/1940-6207.Capr-17-0196  0.412
2017 Leng S, Wu G, Klinge DM, Thomas CL, Casas E, Picchi MA, Stidley CA, Lee SJ, Aisner S, Siegfried JM, Ramalingam S, Khuri FR, Karp DD, Belinsky SA. Gene methylation biomarkers in sputum as a classifier for lung cancer risk. Oncotarget. 8: 63978-63985. PMID 28969046 DOI: 10.18632/Oncotarget.19255  0.441
2017 Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA. ANK1 Methylation Regulates Expression of MicroRNA-486-5p and Discriminates Lung tumors by Histology and Smoking Status. Cancer Letters. PMID 28965852 DOI: 10.1016/J.Canlet.2017.09.038  0.469
2017 Belinsky SA, Leng S, Wu G, Thomas CL, Picchi MA, Lee SJ, Aisner S, Ramalingam S, Khuri FR, Karp DD. Gene Methylation Biomarkers in Sputum and Plasma as Predictors for Lung Cancer Recurrence. Cancer Prevention Research (Philadelphia, Pa.). PMID 28904059 DOI: 10.1158/1940-6207.CAPR-17-0177  0.454
2017 Leng S, Wu G, Klinge DM, Thomas CL, Casas E, Picchi MA, Stidley CA, Lee SJ, Aisner S, Siegfried JM, Ramalingam S, Khuri FR, Karp DD, Belinsky SA. Gene methylation biomarkers in sputum as a classifier for lung cancer risk. Oncotarget. PMID 28754865 DOI: 10.18632/oncotarget.19255  0.441
2017 Xu X, Chen W, Leng S, Padilla MT, Saxton B, Hutt J, Tessema M, Kato K, Kim KC, Belinsky SA, Lin Y. Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop. Carcinogenesis. PMID 28472347 DOI: 10.1093/carcin/bgx039  0.393
2016 Hulbert A, Jusue Torres I, Stark A, Chen C, Rodgers K, Lee B, Griffin C, Yang A, Huang P, Wrangle J, Belinsky SA, Wang TH, Yang SC, Baylin SB, Brock MV, et al. Early Detection of Lung Cancer using DNA Promoter Hypermethylation in Plasma and Sputum. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27729459 DOI: 10.1158/1078-0432.Ccr-16-1371  0.391
2016 Tellez CS, Juri DE, Do KC, Picchi MA, Wang T, Liu G, Spira AE, Belinsky SA. MiR-196b is epigenetically silenced during the pre-malignant stage of lung carcinogenesis. Cancer Research. PMID 27302168 DOI: 10.1158/0008-5472.CAN-15-3367  0.323
2016 Gong Z, Wang D, Espinal A, Hu Q, Sucheston-Campbell L, Tang L, Freudenheim J, Shields P, Morrison C, Belinsky S, Liu S, Demissie K, Higgins M, Ambrosone C. Abstract A31: Genome-wide microRNA profiling analysis of breast cancer among African American and European American women Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-A31  0.316
2016 Rybicki BA, Rundle A, Kryvenko O, Chitale D, Belinsky S, Tang D. Abstract 2635: Methylation in benign prostate and risk of disease progression in men subsequently diagnosed with prostate cancer Cancer Research. 76: 2635-2635. DOI: 10.1158/1538-7445.Am2016-2635  0.353
2016 Leng S, Guillen H, Tellez C, Picchi M, Swenberg J, Gilliland F, Belinsky S. Abstract 2564: Cis and trans quantitative trait loci for MGMT promoter hypermethylation detected in lung exfoliated cells collected in sputum from smokers Epidemiology. 76: 2564-2564. DOI: 10.1158/1538-7445.Am2016-2564  0.426
2015 Leng S, Thomas CL, Snider AM, Picchi MA, Chen W, Willis DG, Carr TG, Krzeminski J, Desai D, Shantu A, Lin Y, Jacobson MR, Belinsky SA. Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners. Environmental Health Perspectives. PMID 26372664 DOI: 10.1289/ehp.1409437  0.303
2015 Tessema M, Yingling CM, Picchi MA, Wu G, Liu Y, Weissfeld JL, Siegfried JM, Tesfaigzi Y, Belinsky SA. Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 10: 1181-8. PMID 26200272 DOI: 10.1097/Jto.0000000000000592  0.31
2015 Leng S, Wu G, Collins LB, Thomas CL, Tellez CS, Jauregui AR, Picchi MA, Zhang X, Juri DE, Desai D, Amin SG, Crowell RE, Stidley CA, Liu Y, Swenberg JA, ... ... Belinsky SA, et al. Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung. Cancer Research. PMID 26183928 DOI: 10.1158/0008-5472.Can-15-0243  0.411
2015 Leng S, Liu Y, Weissfeld JL, Thomas CL, Han Y, Picchi MA, Edlund CK, Willink RP, Gaither Davis AL, Do KC, Nukui T, Zhang X, Burki EA, Van Den Berg D, Romkes M, ... ... Belinsky SA, et al. 15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers. Journal of the National Cancer Institute. 107. PMID 25713168 DOI: 10.1093/Jnci/Djv035  0.449
2015 Belinsky SA. Unmasking the lung cancer epigenome. Annual Review of Physiology. 77: 453-74. PMID 25668024 DOI: 10.1146/annurev-physiol-021014-072018  0.495
2015 Meek PM, Sood A, Petersen H, Belinsky SA, Tesfaigzi Y. Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease. Biological Research For Nursing. 17: 191-8. PMID 24973415 DOI: 10.1177/1099800414538113  0.389
2015 Teneng I, Tellez CS, Picchi MA, Klinge DM, Yingling CM, Snider AM, Liu Y, Belinsky SA. Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer. Oncogene. 34: 621-30. PMID 24469050 DOI: 10.1038/onc.2013.580  0.554
2015 Rybicki B, Jankowski M, Do K, Chitale D, Trudeau S, Rundle A, Belinsky S, Tang D. Abstract A07: Methylation of RARB in prediagnosis benign tissue and risk of disease progression in men subsequently diagnosed with prostate cancer Cancer Prevention Research. 8. DOI: 10.1158/1940-6215.Prev-14-A07  0.368
2014 Tessema M, Yingling CM, Snider AM, Do K, Juri DE, Picchi MA, Zhang X, Liu Y, Leng S, Tellez CS, Belinsky SA. GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 784-93. PMID 24807155 DOI: 10.1097/JTO.0000000000000165  0.422
2014 Tellez CS, Grimes MJ, Picchi MA, Liu Y, March TH, Reed MD, Oganesian A, Taverna P, Belinsky SA. SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome. International Journal of Cancer. Journal International Du Cancer. 135: 2223-31. PMID 24668305 DOI: 10.1002/ijc.28865  0.511
2014 Wrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, Glöckner SC, Tessema M, Van Neste L, Easwaran H, Schuebel KE, Licchesi J, Hooker CM, Ahuja N, Amano J, ... Belinsky SA, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer Clinical Cancer Research. 20: 1856-1864. PMID 24486589 DOI: 10.1158/1078-0432.Ccr-13-2109  0.36
2014 Bruse S, Petersen H, Weissfeld J, Picchi M, Willink R, Do K, Siegfried J, Belinsky SA, Tesfaigzi Y. Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion. Respiratory Research. 15: 2. PMID 24405663 DOI: 10.1186/1465-9921-15-2  0.477
2014 Tessema M, Yingling CM, Liu Y, Tellez CS, Van Neste L, Baylin SS, Belinsky SA. Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. Carcinogenesis. 35: 1248-57. PMID 24398667 DOI: 10.1093/carcin/bgt494  0.523
2014 Kusko R, Garrison C, Wang T, Campbell J, Perez-Rogers J, Luo L, Beane J, Liu G, Kadara H, Belinsky S, Lenburg ME, Spira A. Abstract 3554: Gene and miRNA expression networks specific to never smoker lung adenocarcinoma Cancer Research. 74: 3554-3554. DOI: 10.1158/1538-7445.Am2014-3554  0.448
2014 Statt S, Thai P, Chen C, Cheng Y, Belinsky S, Wu R. Abstract 1469: Functional roles of SCAL1 expression in lung cancer and progression Cancer Research. 74: 1469-1469. DOI: 10.1158/1538-7445.Am2014-1469  0.493
2013 Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, ... ... Belinsky SA, et al. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 18946-51. PMID 24158479 DOI: 10.1073/Pnas.1220319110  0.503
2013 Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, March TH, Kuehl PJ, Belinsky SA. Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model. British Journal of Cancer. 109: 1775-81. PMID 24045660 DOI: 10.1038/bjc.2013.575  0.409
2013 Leng S, Liu Y, Thomas CL, Gauderman WJ, Picchi MA, Bruse SE, Zhang X, Flores KG, Van Den Berg D, Stidley CA, Gilliland FD, Belinsky SA. Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico. American Journal of Respiratory and Critical Care Medicine. 188: 1110-6. PMID 24032348 DOI: 10.1164/Rccm.201305-0925Oc  0.457
2013 Karp DD, Lee SJ, Keller SM, Wright GS, Aisner S, Belinsky SA, Johnson DH, Johnston MR, Goodman G, Clamon G, Okawara G, Marks R, Frechette E, McCaskill-Stevens W, Lippman SM, et al. Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 4179-87. PMID 24002495 DOI: 10.1200/JCO.2013.49.2173  0.326
2013 Leng S, Picchi MA, Liu Y, Thomas CL, Willis DG, Bernauer AM, Carr TG, Mabel PT, Han Y, Amos CI, Lin Y, Stidley CA, Gilliland FD, Jacobson MR, Belinsky SA. Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. Carcinogenesis. 34: 1044-50. PMID 23354305 DOI: 10.1093/Carcin/Bgt024  0.328
2013 Wang T, Campbell J, Kusko R, Luo L, Tellez C, Liu G, Xiao J, Lenburg M, Belinsky S, Spira A. Abstract 1948: Shared and distinct microRNA-expression alterations in lung adenocarcinoma from smokers vs. nonsmokers. Cancer Research. 73: 1948-1948. DOI: 10.1158/1538-7445.Am2013-1948  0.406
2013 Van Neste L, Moreau F, Kelley M, Belinsky S, Bigley J, Van Criekinge W. MC13-0087 Epigenetic assay detects early stage non-small cell lung cancer in sputum European Journal of Cancer. 49: S36. DOI: 10.1016/S0959-8049(13)70191-6  0.342
2012 Bruce VR, Belinsky SA, Gott K, Liu Y, March T, Scott B, Wilder J. Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. Dose-Response : a Publication of International Hormesis Society. 10: 516-26. PMID 23304102 DOI: 10.2203/dose-response.12-040.Bruce  0.308
2012 Flores KG, Stidley CA, Mackey AJ, Picchi MA, Stabler SP, Siegfried JM, Byers T, Berwick M, Belinsky SA, Leng S. Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers. Carcinogenesis. 33: 1542-7. PMID 22665368 DOI: 10.1093/Carcin/Bgs194  0.374
2012 Chen W, Xu X, Bai L, Padilla MT, Gott KM, Leng S, Tellez CS, Wilder JA, Belinsky SA, Scott BR, Lin Y. Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen. Carcinogenesis. 33: 1368-74. PMID 22556270 DOI: 10.1093/carcin/bgs159  0.33
2012 Leng S, Do K, Yingling CM, Picchi MA, Wolf HJ, Kennedy TC, Feser WJ, Baron AE, Franklin WA, Brock MV, Herman JG, Baylin SB, Byers T, Stidley CA, Belinsky SA. Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3387-95. PMID 22510351 DOI: 10.1158/1078-0432.Ccr-11-3049  0.431
2012 Tessema M, Yingling CM, Grimes MJ, Thomas CL, Liu Y, Leng S, Joste N, Belinsky SA. Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers. Plos One. 7: e34850. PMID 22496870 DOI: 10.1371/journal.pone.0034850  0.534
2012 Liu Y, Bernauer AM, Yingling CM, Belinsky SA. HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer. Carcinogenesis. 33: 1187-92. PMID 22467238 DOI: 10.1093/carcin/bgs142  0.416
2012 Xu X, Bai L, Chen W, Padilla MT, Liu Y, Kim KC, Belinsky SA, Lin Y. MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation. Plos One. 7: e33846. PMID 22457794 DOI: 10.1371/journal.pone.0033846  0.364
2012 Tessema M, Yingling CM, Thomas CL, Klinge DM, Bernauer AM, Liu Y, Dacic S, Siegfried JM, Dahlberg SE, Schiller JH, Belinsky SA. SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15. Oncogene. 31: 4107-16. PMID 22158045 DOI: 10.1038/Onc.2011.577  0.46
2012 Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, Landi MT, Thun M, Picchi MA, Bruse SE, Crowell RE, Van Den Berg D, Caporaso NE, Amos CI, Siegfried JM, ... ... Belinsky SA, et al. Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study. Cancer Research. 72: 707-15. PMID 22139380 DOI: 10.1158/0008-5472.Can-11-3194  0.457
2012 Bauman J, Verschraegen C, Belinsky S, Muller C, Rutledge T, Fekrazad M, Ravindranathan M, Lee SJ, Jones D. A phase I study of 5-azacytidine and erlotinib in advanced solid tumor malignancies. Cancer Chemotherapy and Pharmacology. 69: 547-54. PMID 21901396 DOI: 10.1007/S00280-011-1729-2  0.355
2012 Wang TW, Campbell JD, Luo L, Liu G, Xiao J, Lenburg ME, Belinsky SA, Spira A. Deep sequencing of the microRNA transcriptome in current, former, and never smokers with lung adenocarcinoma Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P38  0.385
2012 Tessema M, Yingling CM, Grimes MJ, Thomas CL, Liu Y, Leng S, Joste N, Belinsky S. Abstract 3147: Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers Cancer Research. 72: 3147-3147. DOI: 10.1158/1538-7445.Am2012-3147  0.482
2011 Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, Sebree R, Rodgers K, Hooker CM, Franco N, Lee B, Tsai S, Delgado IE, Rudek MA, Belinsky SA, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discovery. 1: 598-607. PMID 22586682 DOI: 10.1158/2159-8290.Cd-11-0214  0.341
2011 Leng S, Bernauer AM, Zhai R, Tellez CS, Su L, Burki EA, Picchi MA, Stidley CA, Crowell RE, Christiani DC, Belinsky SA. Discovery of common SNPs in the miR-205/200 family-regulated epithelial to mesenchymal transition pathway and their association with risk for non-small cell lung cancer. International Journal of Molecular Epidemiology and Genetics. 2: 145-55. PMID 21686129  0.309
2011 Tellez CS, Juri DE, Do K, Bernauer AM, Thomas CL, Damiani LA, Tessema M, Leng S, Belinsky SA. EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Research. 71: 3087-97. PMID 21363915 DOI: 10.1158/0008-5472.Can-10-3035  0.759
2011 Leng S, Bernauer AM, Hong C, Do KC, Yingling CM, Flores KG, Tessema M, Tellez CS, Willink RP, Burki EA, Picchi MA, Stidley CA, Prados MD, Costello JF, Gilliland FD, ... ... Belinsky SA, et al. The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2014-23. PMID 21355081 DOI: 10.1158/1078-0432.Ccr-10-3026  0.398
2011 Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, Channell MM, Liu Y, Casero RA, Baylin SB, Reed MD, Tellez CS, March TH. Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Research. 71: 454-62. PMID 21224363 DOI: 10.1158/0008-5472.Can-10-3184  0.472
2011 Juergens R, Vendetti F, Wrangle J, Coleman B, Sebree R, Rudek-Renaut M, Belinsky S, Brock M, Herman J, Baylin S, Rudin C. Abstract LB-411: A phase II study of combination epigenetic therapy in advanced non-small cell lung cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-411  0.403
2011 Brock MV, Juergens RA, Wrangle J, Vendetti FP, Murphy S, Zhao M, Coleman B, Sebree R, Rodgers K, Hooker CM, Franco N, Lee B, Tsai S, Delgado IE, Rudek MA, ... Belinsky S, et al. Abstract ED03-04: Using epigenetic biomarkers as prognostic and predictive markers in non-small cell lung cancer (NSCLC) and the promise of epigenetic therapy Cancer Epidemiology, Biomarkers & Prevention. 20. DOI: 10.1158/1055-9965.Disp-11-Ed03-04  0.528
2011 Leng S, Bernauer AM, Zhai R, Tellez CS, Su L, Burki EA, Picchi MA, Stidley CA, Crowell RE, Christiani DC, Belinsky SA. Discovery of common SNPs in the miR-205/200 familyregulatedepithelial to mesenchymal transition pathway and their association with risk for non-small cell lung cancer International Journal of Molecular Epidemiology and Genetics. 2: 145-155.  0.309
2010 Tessema M, Klinge DM, Yingling CM, Do K, Van Neste L, Belinsky SA. Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis Oncogene. 29: 5159-5170. PMID 20562917 DOI: 10.1038/onc.2010.255  0.544
2010 Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin X, Hirsch FR, Kennedy TC, Keith RL, Barón AE, Belinsky SA, Miller YE, Byers T, Franklin WA. The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence. Cancer Prevention Research (Philadelphia, Pa.). 3: 447-53. PMID 20332298 DOI: 10.1158/1940-6207.Capr-09-0165  0.334
2010 Stidley CA, Picchi MA, Leng S, Willink R, Crowell RE, Flores KG, Kang H, Byers T, Gilliland FD, Belinsky SA. Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers. Cancer Research. 70: 568-74. PMID 20068159 DOI: 10.1158/0008-5472.Can-09-3410  0.489
2010 Murray-Stewart T, Belinsky S, Marton L, Casero RA. Abstract LB-97: Combination of a conformationally restricted polyamine analogue with DNA methyltransferase or histone deacetylase inhibition induces synergistic reexpression of aberrantly silenced tumor suppressor genes Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-97  0.514
2009 Juergens RA, Vendetti F, Coleman B, Sebree RS, Rudek MA, Belinsky S, Brock M, Herman J, Baylin S, Rudin CM. Interim analysis of a phase II trial of 5-azacitidine (5AC) and entinostat (SNDX-275) in relapsed advanced lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 8055. PMID 27962870 DOI: 10.1200/Jco.2009.27.15_Suppl.8055  0.518
2009 Pulling LC, Grimes MJ, Damiani LA, Juri DE, Do K, Tellez CS, Belinsky SA. Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer. Carcinogenesis. 30: 2023-30. PMID 19917631 DOI: 10.1093/Carcin/Bgp276  0.711
2009 Lyon CM, Klinge DM, Do KC, Grimes MJ, Thomas CL, Damiani LA, March TH, Stidley CA, Belinsky SA. Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model. Carcinogenesis. 30: 2095-9. PMID 19861651 DOI: 10.1093/Carcin/Bgp260  0.775
2009 Scott BR, Belinsky SA, Leng S, Lin Y, Wilder JA, Damiani LA. Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer. Dose-Response : a Publication of International Hormesis Society. 7: 104-31. PMID 19543479 DOI: 10.2203/Dose-Response.08-016.Scott  0.778
2009 Tessema M, Yu YY, Stidley CA, Machida EO, Schuebel KE, Baylin SB, Belinsky SA. Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers. Carcinogenesis. 30: 1132-8. PMID 19435948 DOI: 10.1093/Carcin/Bgp114  0.56
2008 Tessema M, Belinsky SA. Mining the epigenome for methylated genes in lung cancer. Proceedings of the American Thoracic Society. 5: 806-10. PMID 19017733 DOI: 10.1513/pats.200805-045TH  0.516
2008 Damiani LA, Yingling CM, Leng S, Romo PE, Nakamura J, Belinsky SA. Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Research. 68: 9005-14. PMID 18974146 DOI: 10.1158/0008-5472.Can-08-1276  0.8
2008 Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, ... ... Belinsky SA, et al. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Research. 68: 8535-40. PMID 18922928 DOI: 10.1158/0008-5472.Can-08-2129  0.354
2008 Belinsky SA, Schiller JH, Stidley CA. DNA methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer. Nutrition Reviews. 66: S24-6. PMID 18673483 DOI: 10.1111/j.1753-4887.2008.00061.x  0.389
2008 Wakamatsu N, Collins JB, Parker JS, Tessema M, Clayton NP, Ton TV, Hong HH, Belinsky S, Devereux TR, Sills RC, Lahousse SA. Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors. Toxicologic Pathology. 36: 743-52. PMID 18648096 DOI: 10.1177/0192623308320801  0.441
2008 Leng S, Stidley CA, Willink R, Bernauer A, Do K, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Zima C, Crowell RE, Belinsky SA. Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation. Cancer Research. 68: 3049-56. PMID 18413776 DOI: 10.1158/0008-5472.Can-07-6344  0.446
2008 Tessema M, Willink R, Do K, Yu YY, Yu W, Machida EO, Brock M, Van Neste L, Stidley CA, Baylin SB, Belinsky SA. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Research. 68: 1707-14. PMID 18339850 DOI: 10.1158/0008-5472.Can-07-6325  0.537
2008 Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, Ames S, Glöckner S, Piantadosi S, Gabrielson E, Pridham G, Pelosky K, Belinsky SA, Yang SC, Baylin SB, Herman JG. DNA methylation markers and early recurrence in stage I lung cancer. The New England Journal of Medicine. 358: 1118-28. PMID 18337602 DOI: 10.1056/Nejmoa0706550  0.462
2008 Luxen S, Belinsky SA, Knaus UG. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Research. 68: 1037-45. PMID 18281478 DOI: 10.1158/0008-5472.CAN-07-5782  0.507
2008 Juergens RA, Vendetti F, Coleman B, Sebree RS, Rudek MA, Belinsky SA, Brock MV, Herman JG, Baylin SB, Rudin CM. Phase I trial of 5-azacitidine (5AC) and SNDX-275 in advanced lung cancer (NSCLC) Journal of Clinical Oncology. 26: 19036-19036. DOI: 10.1200/Jco.2008.26.15_Suppl.19036  0.366
2007 Lyon CM, Klinge DM, Liechty KC, Gentry FD, March TH, Kang T, Gilliland FD, Adamova G, Rusinova G, Telnov V, Belinsky SA. Radiation-induced lung adenocarcinoma is associated with increased frequency of genes inactivated by promoter hypermethylation. Radiation Research. 168: 409-14. PMID 17903034 DOI: 10.1667/Rr0825.1  0.518
2007 Belinsky SA, Grimes MJ, Casas E, Stidley CA, Franklin WA, Bocklage TJ, Johnson DH, Schiller JH. Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum. British Journal of Cancer. 96: 1278-83. PMID 17406356 DOI: 10.1038/sj.bjc.6603721  0.45
2007 Liu H, Zhou Y, Boggs SE, Belinsky SA, Liu J. Cigarette smoke induces demethylation of prometastatic oncogene synuclein-γ in lung cancer cells by downregulation of DNMT3B Oncogene. 26: 5900-5910. PMID 17369845 DOI: 10.1038/sj.onc.1210400  0.442
2007 Franklin WA, Byers T, Wolf HJ, Braudich S, Hirsch FR, Miller YE, Keith RL, Kennedy TC, Belinsky S, Varella-Garcia M. FISHing for lung cancer: Promising findings using multi-targeted interphase fluorescence in situ hybridization (FISH) for lung cancer detection in sputum Journal of Clinical Oncology. 25: 7567-7567. DOI: 10.1200/Jco.2007.25.18_Suppl.7567  0.462
2007 Lyon CM, Belinsky SA, Klinge D, March T, Keith R, Stidley C. P2-137: Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model Journal of Thoracic Oncology. 2: S545-S546. DOI: 10.1097/01.JTO.0000283601.08974.3f  0.339
2006 Machida EO, Brock MV, Hooker CM, Nakayama J, Ishida A, Amano J, Picchi MA, Belinsky SA, Herman JG, Taniguchi S, Baylin SB. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Research. 66: 6210-8. PMID 16778195 DOI: 10.1158/0008-5472.Can-05-4447  0.403
2006 Vuillemenot BR, Hutt JA, Belinsky SA. Gene promoter hypermethylation in mouse lung tumors. Molecular Cancer Research : McR. 4: 267-73. PMID 16603640 DOI: 10.1158/1541-7786.MCR-05-0218  0.579
2006 Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, Haney J, Kennedy TC, Hirsch FR, Miller Y, Franklin WA, Herman JG, Baylin SB, Bunn PA, Byers T. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Research. 66: 3338-44. PMID 16540689 DOI: 10.1158/0008-5472.Can-05-3408  0.47
2006 Belinsky SA, Grimes M, Johnson D, Levy D, Schiller J. Predicting gene promoter methylation in lung tumors through examination of sputum and serum Journal of Clinical Oncology. 24: 7208-7208. DOI: 10.1200/jco.2006.24.18_suppl.7208  0.494
2005 Belinsky SA, Klinge DM, Dekker JD, Smith MW, Bocklage TJ, Gilliland FD, Crowell RE, Karp DD, Stidley CA, Picchi MA. Gene promoter methylation in plasma and sputum increases with lung cancer risk. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 6505-11. PMID 16166426 DOI: 10.1158/1078-0432.Ccr-05-0625  0.426
2005 Hutt JA, Vuillemenot BR, Barr EB, Grimes MJ, Hahn FF, Hobbs CH, March TH, Gigliotti AP, Seilkop SK, Finch GL, Mauderly JL, Belinsky SA. Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways. Carcinogenesis. 26: 1999-2009. PMID 15944214 DOI: 10.1093/carcin/bgi150  0.402
2005 Belinsky SA. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis. 26: 1481-7. PMID 15661809 DOI: 10.1093/carcin/bgi020  0.522
2005 Divine KK, Pulling LC, Marron-Terada PG, Liechty KC, Kang T, Schwartz AG, Bocklage TJ, Coons TA, Gilliland FD, Belinsky SA. Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers. International Journal of Cancer. 114: 400-5. PMID 15578700 DOI: 10.1002/Ijc.20761  0.794
2004 Belinsky SA. Gene-promoter hypermethylation as a biomarker in lung cancer. Nature Reviews. Cancer. 4: 707-17. PMID 15343277 DOI: 10.1038/nrc1432  0.451
2004 Mauderly JL, Gigliotti AP, Barr EB, Bechtold WE, Belinsky SA, Hahn FF, Hobbs CA, March TH, Seilkop SK, Finch GL. Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 81: 280-92. PMID 15213336 DOI: 10.1093/toxsci/kfh203  0.354
2004 Pulling LC, Vuillemenot BR, Hutt JA, Devereux TR, Belinsky SA. Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens. Cancer Research. 64: 3844-8. PMID 15172992 DOI: 10.1158/0008-5472.Can-03-2119  0.81
2004 Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB. Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Research. 64: 1611-20. PMID 14996719 DOI: 10.1158/0008-5472.Can-0318-2  0.316
2004 Belinsky SA, Klinge DM, Liechty KC, March TH, Kang T, Gilliland FD, Sotnic N, Adamova G, Rusinova G, Telnov V. Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. Carcinogenesis. 25: 1063-7. PMID 14742312 DOI: 10.1093/Carcin/Bgh096  0.459
2004 Vuillemenot BR, Pulling LC, Palmisano WA, Hutt JA, Belinsky SA. Carcinogen exposure differentially modulates RAR-beta promoter hypermethylation, an early and frequent event in mouse lung carcinogenesis. Carcinogenesis. 25: 623-9. PMID 14656941 DOI: 10.1093/Carcin/Bgh038  0.801
2003 Belinsky SA, Klinge DM, Stidley CA, Issa JP, Herman JG, March TH, Baylin SB. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Research. 63: 7089-93. PMID 14612500  0.511
2003 Pulling LC, Divine KK, Klinge DM, Gilliland FD, Kang T, Schwartz AG, Bocklage TJ, Belinsky SA. Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression. Cancer Research. 63: 4842-8. PMID 12941804  0.787
2003 Palmisano WA, Crume KP, Grimes MJ, Winters SA, Toyota M, Esteller M, Joste N, Baylin SB, Belinsky SA. Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers. Cancer Research. 63: 4620-5. PMID 12907641  0.467
2003 West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of Clinical Investigation. 111: 81-90. PMID 12511591 DOI: 10.1172/Jci16147  0.418
2003 West KA, Linnoila IR, Brognard J, Belinsky S, Harris CC, Dennis PA. P-326 Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo Lung Cancer. 41. DOI: 10.1016/S0169-5002(03)92294-X  0.318
2002 Wardlaw SA, Zhang N, Belinsky SA. Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. Molecular Pharmacology. 62: 326-33. PMID 12130685 DOI: 10.1124/mol.62.2.326  0.35
2002 Belinsky SA, Palmisano WA, Gilliland FD, Crooks LA, Divine KK, Winters SA, Grimes MJ, Harms HJ, Tellez CS, Smith TM, Moots PP, Lechner JF, Stidley CA, Crowell RE. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Research. 62: 2370-7. PMID 11956099  0.531
2002 Gilliland FD, Harms HJ, Crowell RE, Li YF, Willink R, Belinsky SA. Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum. Cancer Research. 62: 2248-52. PMID 11956078  0.448
2002 Cohen AJ, Belinsky S, Franklin W, Beard S. Molecular and physiologic evidence for 5'CpG island methylation of the endothelin B receptor gene in lung cancer. Chest. 121: 27S-28S. PMID 11893663 DOI: 10.1378/Chest.121.3_Suppl.27S-A  0.515
2002 Belinsky SA, Snow SS, Nikula KJ, Finch GL, Tellez CS, Palmisano WA. Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens. Carcinogenesis. 23: 335-9. PMID 11872642  0.5
2002 Belinsky SA, Divine KK, Esteller M, Baylin SB, Herman JG, Palmisano WA. Aberrant promoter methylation in sputum and serum for lung cancer detection Journal of Clinical Ligand Assay. 25: 95-99.  0.47
2001 Auckley DH, Crowell RE, Heaphy ER, Stidley CA, Lechner JF, Gilliland FD, Belinsky SA. Reduced DNA-dependent protein kinase activity is associated with lung cancer Carcinogenesis. 22: 723-727. PMID 11323390 DOI: 10.1093/Carcin/22.5.723  0.331
2001 Pulling LC, Klinge DM, Belinsky SA. p16INK4a and beta-catenin alterations in rat liver tumors induced by NNK. Carcinogenesis. 22: 461-6. PMID 11238187 DOI: 10.1093/Carcin/22.3.461  0.762
2001 Lechner JF, Fugaro JM, Wong Y, Pass HI, Harris CC, Belinsky SA. Perspective: Cell differentiation theory may advance early detection of and therapy for lung cancer Radiation Research. 155: 235-238. PMID 11121240  0.373
2001 Divine KK, Gilliland FD, Crowell RE, Stidley CA, Bocklage TJ, Cook DL, Belinsky SA. The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung. Mutation Research. 461: 273-8. PMID 11104903 DOI: 10.1016/S0921-8777(00)00059-8  0.314
2001 March TH, Marron-Terada PG, Belinsky SA. Refinement of an orthotopic lung cancer model in the nude rat Veterinary Pathology. 38: 483-490. DOI: 10.1354/vp.38-5-483  0.421
2000 Palmisano WA, Divine KK, Saccomanno G, Gilliland FD, Baylin SB, Herman JG, Belinsky SA. Predicting lung cancer by detecting aberrant promoter methylation in sputum Cancer Research. 60: 5954-5958. PMID 11085511  0.445
2000 Baylin SB, Belinsky SA, Herman JG. Aberrant methylation of gene promoters in cancer - Concepts, misconcepts, and promise Journal of the National Cancer Institute. 92: 1460-1461. PMID 10995795 DOI: 10.1093/Jnci/92.18.1460  0.486
2000 Wardlaw SA, March TH, Belinsky SA. Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions Carcinogenesis. 21: 1371-1377. PMID 10874016  0.424
1999 Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis Proceedings of the National Academy of Sciences of the United States of America. 96: 12754-12759. PMID 10535995 DOI: 10.1073/Pnas.96.22.12754  0.406
1998 Neft RE, Crowell RE, Gilliland FD, Murphy MM, Lane JL, Harms H, Coons T, Heaphy E, Belinsky SA, Lechner JF. Frequency of trisomy 20 in nonmalignant bronchial epithelium from lung cancer patients and cancer-free former uranium miners and smokers Cancer Epidemiology Biomarkers and Prevention. 7: 1051-1054. PMID 9829716  0.36
1998 Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, Herman JG. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proceedings of the National Academy of Sciences of the United States of America. 95: 11891-11896. PMID 9751761 DOI: 10.1073/Pnas.95.20.11891  0.478
1998 Jones-Bolin SE, Johansson E, Palmisano WA, Anderson MW, Wiest JS, Belinsky SA. Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression Carcinogenesis. 19: 1503-1508. PMID 9744549 DOI: 10.1093/carcin/19.8.1503  0.394
1998 Belinsky SA. Role of the cytosine DNA-methyltransferase and p16(INK4a) genes in the development of mouse lung tumors Experimental Lung Research. 24: 463-479. PMID 9659578  0.507
1998 Kennedy CH, Cueto R, Belinsky SA, Lechner JF, Pryor WA. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. Febs Letters. 429: 17-20. PMID 9657375 DOI: 10.1016/S0014-5793(98)00505-5  0.319
1998 Lechner JF, Neft RE, Gilliland FD, Crowell RE, Auckley DH, Temes RT, Belinsky SA. Individuals at high risk for lung cancer have airway epithelial cells with chromosome aberrations frequently found in lung tumor cells In Vivo. 12: 23-26. PMID 9575422  0.383
1997 Crowell RE, Belinsky SA. Genetic changes in lung cancer: Potential biomarkers for early detection and prevention Journal of Laboratory and Clinical Medicine. 130: 550-557. PMID 9422328  0.367
1997 Lechner JF, Neft RE, Gilliland FD, Crowell RE, Belinsky SA. Molecular identification of individuals at high risk for lung cancer Radiation Oncology Investigations. 5: 103-105. PMID 9303064 DOI: 10.1002/(SICI)1520-6823(1997)5:3<103::AID-ROI3>3.0.CO;2-1  0.305
1997 Belinsky SA, Swafford DS, Finch GL, Mitchell CE, Kelly G, Hahn FF, Anderson MW, Nikula KJ. Alterations in the K-ras and p53 genes in rat lung tumors. Environmental Health Perspectives. 105: 901-6. PMID 9255578  0.419
1997 Belinsky SA, Swafford DS, Middleton SK, Kennedy CH, Tesfaigzi J. Deletion and differential expression of p16INK4a in mouse lung tumors. Carcinogenesis. 18: 115-20. PMID 9054597 DOI: 10.1093/carcin/18.1.115  0.391
1997 Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG, Belinsky SA. Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Molecular and Cellular Biology. 17: 1366-74. PMID 9032263 DOI: 10.1128/Mcb.17.3.1366  0.491
1997 Tierney LA, Neft RE, Belinsky SA, Lauer FT, Gilliland FD, Crowell RE, Lechner JF. Double-label suspension immunohistochemistry for the detection of gene dysfunction in sputum Journal of Histotechnology. 20: 13-17. DOI: 10.1179/His.1997.20.1.13  0.302
1997 Belinsky S, Crowell R, Neft R, Gilliland F, Lechner J. 728 Loss of chromosome 9q21-23 in nonmalignant bronchial epithelial cells from individuals at risk for lung cancer Lung Cancer. 18: 187. DOI: 10.1016/S0169-5002(97)80108-0  0.366
1996 Finch GL, Hoover MD, Hahn FF, Nikula KJ, Belinsky SA, Haley PJ, Griffith WC. Animal models of beryllium-induced lung disease. Environmental Health Perspectives. 104: 973-9. PMID 8933044  0.36
1996 Issa JPJ, Baylin SB, Belinsky SA. Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure Cancer Research. 56: 3655-3658. PMID 8706002  0.531
1996 Belinsky SA, Nikula KJ, Baylin SB, Issa JPJ. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer Proceedings of the National Academy of Sciences of the United States of America. 93: 4045-4050. PMID 8633014 DOI: 10.1073/Pnas.93.9.4045  0.372
1996 Finch GL, Nikula KJ, Belinsky SA, Barr EB, Stoner GD, Lechner JF. Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse Cancer Letters. 99: 161-167. PMID 8616820 DOI: 10.1016/0304-3835(95)04059-5  0.372
1996 Belinsky SA, Middleton SK, Picksley SM, Hahn FF, Nikula KJ. Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat Radiation Research. 145: 449-456. PMID 8600505 DOI: 10.2307/3579066  0.356
1995 Belinsky SA, Nikula KJ, Baylin SB, Issa Jp. A microassay for measuring cytosine DNA methyltransferase activity during tumor progression Toxicology Letters. 82: 335-340. PMID 8597074 DOI: 10.1016/0378-4274(95)03486-2  0.366
1995 Shivapurkar N, Belinsky SA, Wolf DC, Tang Z, Alabaster O. Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane Cancer Letters. 96: 63-70. PMID 7553609 DOI: 10.1016/0304-3835(95)03947-U  0.328
1995 Swafford DS, Nikula KJ, Mitchell CE, Belinsky SA. Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black. Carcinogenesis. 16: 1215-21. PMID 7539340 DOI: 10.1093/carcin/16.5.1215  0.32
1994 Nickell-Brady C, Hahn FF, Finch GL, Belinsky SA. Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors. Carcinogenesis. 15: 257-62. PMID 7545909 DOI: 10.1093/carcin/15.2.257  0.409
1993 Belinsky SA, Stefanski SA, Anderson2 MW. The A/J Mouse Lung as a Model for Developing New Chemointervention Strategies Cancer Research. 53: 410-416. PMID 8417832  0.348
1993 Devereux TR, Belinsky SA, Maronpot RR, White CM, Hegi ME, Patel AC, Foley JF, Greenwell A, Anderson MW. Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains. Molecular Carcinogenesis. 8: 177-85. PMID 8216736 DOI: 10.1002/mc.2940080308  0.362
1991 Belinsky SA, Devereux TR, White CM, Foley JF, Maronpot RR, Anderson MW. Role of clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine Experimental Lung Research. 17: 263-278. PMID 2050030 DOI: 10.3109/01902149109064417  0.371
1991 Devereux TR, Anderson MW, Belinsky SA. Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant c3h mouse Carcinogenesis. 12: 299-303. PMID 1995195 DOI: 10.1093/Carcin/12.2.299  0.433
1990 Belinsky SA, Foley JF, White CM, Anderson MW, Maronpot RR. Dose-Response Relationship between O6-Methylguanine Formation in Clara Cells and Induction of Pulmonary Neoplasia in the Rat by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Cancer Research. 50: 3772-3780. PMID 2340522  0.35
1990 Belinsky SA, Devereux TR, Anderson MW. Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 233: 105-116. PMID 2233792 DOI: 10.1016/0027-5107(90)90155-W  0.439
1989 Belinsky SA, Devereux TR, Anderson MW, Maronpot RR, Stoner GD. Relationship between the Formation of Promutagenic Adducts and the Activation of the K-ras Protooncogene in Lung Tumors from A/J Mice Treated with Nitrosamines Cancer Research. 49: 5305-5311. PMID 2670201  0.415
1988 Devereux TR, Anderson MW, Belinsky SA. Factors Regulating Activation and DNA Alkylation by 4-(N-Methyl-N-nitrosamino)- 1 -(3-pyridyl)-l -butanone and Nitrosodimethylamine in Rat Lung and Isolated Lung Cells, and the Relationship to Carcinogenicity Cancer Research. 48: 4215-4221. PMID 3390815  0.345
1987 Belinsky SA, White CM, Devereux TR, Swenberg JA, Anderson MW. Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Research. 47: 1143-8. PMID 3802095  0.333
Low-probability matches (unlikely to be authored by this person)
1986 Belinsky SA, White CM, Boucheron JA, Richardson FC, Swenberg JA, Anderson M. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Research. 46: 1280-4. PMID 3943097  0.299
1992 Belinsky SA, Devereux TR, Foley JF, Maronpot RR, Anderson MW. Role of the Alveolar Type II Cell in the Development and Progression of Pulmonary Tumors Induced by 4-(Methylnitrosamino)-l-(3-pyridyl)-1-butanone in the A/J Mouse Cancer Research. 52: 3164-3173. PMID 1591728  0.297
2007 Belinsky SA. M15-01: Integrating epigenetic and genetic biomarkers for early lung cancer detection Journal of Thoracic Oncology. 2: S190-S191. DOI: 10.1097/01.JTO.0000282969.68425.3a  0.293
2012 Hoang T, Dahlberg SE, Schiller JH, Mehta MP, Fitzgerald TJ, Belinsky SA, Johnson DH. Randomized phase III study of thoracic radiation in combination with paclitaxel and carboplatin with or without thalidomide in patients with stage III non-small-cell lung cancer: the ECOG 3598 study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 616-22. PMID 22271472 DOI: 10.1200/JCO.2011.36.9116  0.29
1993 Hegi ME, Fox TR, Belinsky SA, Devereux TR, Anderson MW. Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator Carcinogenesis. 14: 145-149. PMID 8425263 DOI: 10.1093/Carcin/14.1.145  0.289
2019 Verco J, Johnston W, Frost M, Baltezor M, Kuehl PJ, Lopez A, Gigliotti A, Belinsky SA, Wolff R, diZerega G. Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer. Journal of Aerosol Medicine and Pulmonary Drug Delivery. PMID 31347939 DOI: 10.1089/jamp.2018.1517  0.289
2016 Gong Z, Wang D, Espinal A, Hu Q, Peng X, Sucheston-Campbell L, Tang L, Freudenheim J, Shields P, Morrison C, Belinsky S, Liu S, Demissie K, Higgins M, Ambrosone C. Abstract 1960: Identification of differentially expressed miRNAs of breast cancer among African American and European American women Cancer Research. 76: 1960-1960. DOI: 10.1158/1538-7445.Am2016-1960  0.289
2009 Bailey VJ, Easwaran H, Zhang Y, Griffiths E, Belinsky SA, Herman JG, Baylin SB, Carraway HE, Wang TH. MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Research. 19: 1455-61. PMID 19443857 DOI: 10.1101/Gr.088831.108  0.288
2004 West KA, Linnoila IR, Belinsky SA, Harris CC, Dennis PA. Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. Cancer Research. 64: 446-51. PMID 14744754 DOI: 10.1158/0008-5472.CAN-03-3241  0.287
2014 Xu X, Padilla MT, Li B, Wells A, Kato K, Tellez C, Belinsky SA, Kim KC, Lin Y. MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Research. 74: 460-70. PMID 24282280 DOI: 10.1158/0008-5472.CAN-13-1713  0.286
2021 Kuehl PJ, Yingling CM, Dubose D, Burke M, Revelli DA, Chen W, Dye WW, Belinsky SA, Tessema M. Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer. Drug Delivery. 28: 767-775. PMID 33860729 DOI: 10.1080/10717544.2021.1912209  0.281
2019 Chen W, Do KC, Saxton B, Leng S, Filipczak P, Tessema M, Belinsky SA, Lin Y. Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small cell lung cancer cells. Molecular Carcinogenesis. PMID 30790354 DOI: 10.1002/mc.22992  0.277
1987 Belinsky SA, White CM, Devereux TR, Anderson MW. DNA adducts as a dosimeter for risk estimation Environmental Health Perspectives. 76: 3-8. PMID 3447903 DOI: 10.1289/Ehp.87763  0.277
2008 Leng S, Stidley CA, Bernauer AM, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Crowell RE, Belinsky SA. Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. Carcinogenesis. 29: 1380-5. PMID 18499700 DOI: 10.1093/Carcin/Bgn121  0.274
2006 Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Research. 66: 1089-95. PMID 16424045 DOI: 10.1158/0008-5472.CAN-05-2698  0.273
2022 Leng S, Picchi MA, Meek PM, Jiang M, Bayliss SH, Zhai T, Bayliyev RI, Tesfaigzi Y, Campen MJ, Kang H, Zhu Y, Lan Q, Sood A, Belinsky SA. Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers. Respiratory Research. 23: 236. PMID 36076291 DOI: 10.1186/s12931-022-02162-y  0.272
2012 Belinsky SA, Spira A, Tellez C. Abstract CN06-02: Epigenetic Deregulation of MicroRNAs During Tobacco Carcinogen-Induced Transformation of Bronchial Epithelial Cells Cancer Prevention Research. 5: CN06-02-CN06-02. DOI: 10.1158/1940-6207.PREV-12-CN06-02  0.272
1994 Mauderly JL, Snipes MB, Barr EB, Belinsky SA, Bond JA, Brooks AL, Chang IY, Cheng YS, Gillett NA, Griffith WC. Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: Neoplastic and nonneoplastic lung lesions. Research Report (Health Effects Institute). 1-75; discussion 77-. PMID 7530965  0.269
2019 Chen W, Wang Q, Xu X, Saxton B, Tessema M, Leng S, Choksi S, Belinsky SA, Liu ZG, Lin Y. Vasorin/ATIA Promotes Cigarette Smoke-Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis. Translational Oncology. 13: 32-41. PMID 31760267 DOI: 10.1016/j.tranon.2019.09.001  0.266
2010 Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y. Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers. American Journal of Respiratory and Critical Care Medicine. 182: 1098-104. PMID 20595226 DOI: 10.1164/Rccm.201002-0222Oc  0.263
2014 Bauman J, Shaheen M, Verschraegen CF, Belinsky SA, Houman Fekrazad M, Lee FC, Rabinowitz I, Ravindranathan M, Jones DV. A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers. Translational Oncology. PMID 24746712 DOI: 10.1016/j.tranon.2014.03.001  0.259
2007 Ju W, Wang X, Shi H, Chen W, Belinsky SA, Lin Y. A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Molecular Pharmacology. 71: 1381-8. PMID 17296806 DOI: 10.1124/mol.106.032185  0.257
2010 Chen W, Bai L, Wang X, Xu S, Belinsky SA, Lin Y. Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Molecular Pharmacology. 77: 416-23. PMID 19933775 DOI: 10.1124/mol.109.061226  0.254
1989 Belinsky SA, White CM, Trushin N, Hecht SS. Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the fischer rat Carcinogenesis. 10: 2269-2274. PMID 2591016 DOI: 10.1093/Carcin/10.12.2269  0.252
2013 Tang D, Kryvenko ON, Mitrache N, Do KC, Jankowski M, Chitale DA, Trudeau S, Rundle A, Belinsky SA, Rybicki BA. Methylation of the RARB gene increases prostate cancer risk in black Americans. The Journal of Urology. 190: 317-24. PMID 23376149 DOI: 10.1016/J.Juro.2013.01.083  0.247
2007 Kagan J, Srivastava S, Barker PE, Belinsky SA, Cairns P. Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools. Cancer Research. 67: 4545-9. PMID 17510378 DOI: 10.1158/0008-5472.Can-06-2888  0.243
1988 Belinsky SA, Dolan ME, White CM, Maronpot RR, Pegg AE, Anderson MW. Cell specific differences in o-methylguanine-dna methyltransferase activity and removal of o-methylguanine in rat pulmonary cells Carcinogenesis. 9: 2053-2058. PMID 3180342 DOI: 10.1093/carcin/9.11.2053  0.24
2019 Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, ... ... Belinsky SA, et al. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nature Genetics. PMID 30804561 DOI: 10.1038/S41588-018-0342-2  0.236
2003 Tesfaigzi Y, Wright PS, Belinsky SA. SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L889-98. PMID 12832281 DOI: 10.1152/Ajplung.00065.2003  0.236
2023 Tellez CS, Grimes MJ, Juri DE, Do K, Willink R, Dye WW, Wu G, Picchi MA, Belinsky SA. Flavored E-cigarette product aerosols induce transformation of human bronchial epithelial cells. Lung Cancer (Amsterdam, Netherlands). 179: 107180. PMID 36989612 DOI: 10.1016/j.lungcan.2023.107180  0.232
2016 Rybicki BA, Rundle A, Kryvenko ON, Mitrache N, Do KC, Jankowski M, Chitale DA, Trudeau S, Belinsky SA, Tang D. Methylation in Benign Prostate and Risk of Disease Progression in Men Subsequently Diagnosed with Prostate Cancer. International Journal of Cancer. Journal International Du Cancer. PMID 26860439 DOI: 10.1002/Ijc.30038  0.227
2002 Belinsky SA. Epigenetics is alive and growing. Trends in Molecular Medicine. 8: 53-4. PMID 11815265 DOI: 10.1016/S1471-4914(02)02284-0  0.227
2016 Filipczak PT, Thomas CL, Chen W, Salzman A, McDonald JD, Lin Y, Belinsky SA. TSC2 deficiency unmasks a novel necrosis pathway that is suppressed by the RIP1/RIP3/MLKL signaling cascade. Cancer Research. PMID 27756752 DOI: 10.1158/0008-5472.CAN-16-1052  0.225
2018 Verco J, Johnston W, Baltezor M, Kuehl PJ, Gigliotti A, Belinsky SA, Lopez A, Wolff R, Hylle L, diZerega G. Pharmacokinetic Profile of Inhaled Submicron Particle Paclitaxel (NanoPac) in a Rodent Model. Journal of Aerosol Medicine and Pulmonary Drug Delivery. PMID 30359162 DOI: 10.1089/jamp.2018.1467  0.224
2014 Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS, Leng S, Padilla MT, Nyunoya T, Belinsky SA, Lin Y. RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis. Cell Death and Differentiation. 21: 1061-70. PMID 24583643 DOI: 10.1038/cdd.2014.25  0.224
1995 Belinsky SA, Lechner JF, Johnson NF. An improved method for the isolation of type II and clara cells from mice In Vitro Cellular &Amp; Developmental Biology - Animal: Journal of the Society For in Vitro Biology. 31: 361-366. PMID 7543342 DOI: 10.1007/BF02634285  0.223
2008 Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, Lin Y. Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Molecular Cancer Therapeutics. 7: 1156-63. PMID 18483303 DOI: 10.1158/1535-7163.Mct-07-2183  0.222
2017 Leng S, Picchi MA, Tesfaigzi Y, Wu G, Gauderman WJ, Xu F, Gilliland FD, Belinsky SA. Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico. International Journal of Chronic Obstructive Pulmonary Disease. 12: 3171-3181. PMID 29133979 DOI: 10.2147/Copd.S142237  0.215
2008 Sood A, Stidley CA, Picchi MA, Celedón JC, Gilliland F, Crowell RE, Belinsky SA, Tesfaigzi Y. Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers. Copd. 5: 274-81. PMID 18972275 DOI: 10.1080/15412550802363345  0.214
1985 Belinsky SA, White CM, Boucheron JA. Accumulation of DNA adducts in hepatic and respiratory tissue following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone (NNK) Proceedings of the American Association For Cancer Research.  0.214
1995 Mitchell CE, Belinsky SA, Lechner JF. Detection and quantitation of mutant K-ras codon 12 restriction fragments by capillary electrophoresis. Analytical Biochemistry. 224: 148-53. PMID 7710062 DOI: 10.1006/abio.1995.1020  0.211
2008 Leng S, Bernauer A, Stidley CA, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Crowell RE, Belinsky SA. Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 2062-9. PMID 18708399 DOI: 10.1158/1055-9965.Epi-08-0308  0.21
2022 Zhai T, Diergaarde B, Wilson DO, Kang H, Sood A, Bayliss SH, Yuan JM, Picchi MA, Lan Q, Belinsky SA, Siegfried JM, Cook LS, Leng S. Early natural menopause is associated with poor lung health and increased mortality among female smokers. American Journal of Obstetrics and Gynecology. PMID 35934119 DOI: 10.1016/j.ajog.2022.07.031  0.209
2018 Gong Z, Wang J, Wang D, Buas MF, Ren X, Freudenheim J, Belinsky SA, Liu S, Ambrosone CB, Higgins MJ. Differences in microRNA expression in breast cancer between women of African and European ancestry. Carcinogenesis. PMID 30321299 DOI: 10.1093/Carcin/Bgy134  0.208
2021 Chen W, Saxton B, Tessema M, Belinsky SA. Inhibition of GFAT1 in lung cancer cells destabilizes PD-L1 protein. Carcinogenesis. PMID 34270713 DOI: 10.1093/carcin/bgab063  0.207
2016 Leng S, Weissfeld JL, Picchi MA, Styn MA, Claus ED, Clark VP, Wu G, Thomas CL, Gilliland FD, Yuan J, Siegfried JM, Belinsky SA. A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania. International Journal of Molecular Epidemiology and Genetics. 7: 95-104. PMID 27335628  0.206
2021 Tellez CS, Juri DE, Phillips LM, Do K, Thomas CL, Willink R, Dye WW, Wu G, Zhou Y, Irshad H, Kishida S, Kiyono T, Belinsky SA. Comparative Genotoxicity and Mutagenicity of Cigarette, Cigarillo, and Shisha Tobacco Products in Epithelial and Cardiac Cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 34390580 DOI: 10.1093/toxsci/kfab101  0.203
2016 Bruse S, Moreau M, Bromberg Y, Jang JH, Wang N, Ha H, Picchi M, Lin Y, Langley RJ, Qualls C, Klensney-Tait J, Zabner J, Leng S, Mao J, Belinsky SA, et al. Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility. Human Genomics. 10: 1. PMID 26744305 DOI: 10.1186/S40246-015-0058-7  0.202
1987 Belinsky SA, Swenberg JA, Anderson MW. Molecular dosimetry of O6-methylguanine formation and cell toxicity in lung and nasal mucosa by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone. Iarc Scientific Publications. 430-3. PMID 3679414  0.201
2011 Rybicki B, Mitrache N, Do K, Jankowski M, Tang D, Rundle A, Bock C, Beebe-Dimmer J, Belinsky S. Methylation of Retinoic Acid Receptor, Beta (RARB) Gene Increases Risk for Prostate Cancer in African-American Men Cancer Epidemiology Biomarkers & Prevention. 20: 718-718. DOI: 10.1158/1055-9965.Epi-11-0091  0.193
2017 Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, ... ... Belinsky SA, et al. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nature Genetics. PMID 28166215 DOI: 10.1038/Ng.3752  0.192
2004 West KA, Linnoila IR, Brognard J, Belinsky S, Harris C, Dennis PA. Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo. Chest. 125: 101S-2S. PMID 15136436 DOI: 10.1378/Chest.125.5_Suppl.101S  0.189
2020 Cheng W, Liu Y, Tang J, Duan H, Wei X, Zhang X, Yu S, Campen MJ, Han W, Rothman N, Belinsky SA, Lan Q, Zheng Y, Leng S. Carbon content in airway macrophages and genomic instability in Chinese carbon black packers. Archives of Toxicology. PMID 32076763 DOI: 10.1007/S00204-020-02678-6  0.184
1993 Mitchell CE, Bechtold WE, Belinsky SA. Metabolism of nitrofluoranthenes by rat lung subcellular fractions. Carcinogenesis. 14: 1161-6. PMID 8508503 DOI: 10.1093/carcin/14.6.1161  0.183
1999 Henderson RF, Hahn FF, Barr EB, Belinsky SA, Ménache MG, Benson JM. Carcinogenicity of inhaled butadiene diepoxide in female B6C3F1 mice and Sprague-Dawley rats Toxicological Sciences. 52: 33-44. PMID 10568696  0.182
2020 Crosby L, Yucesoy B, Leggett C, Tu Z, Belinsky SA, McDonald J, Leng S, Wu G, Irshad H, Valerio LG, Rosenfeldt H. Smoke Chemistry, In vitro Cytotoxicity, and Genotoxicity Demonstrates Enhanced Toxicity of Cigarillos Compared to Cigarettes. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33021639 DOI: 10.1093/toxsci/kfaa155  0.18
2012 Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y. Methylated Genes in Sputum Among Older Smokers With Asthma. Chest. 142: 425-31. PMID 22345380 DOI: 10.1378/Chest.11-2519  0.179
2011 Bruse S, Sood A, Petersen H, Liu Y, Leng S, Celedón JC, Gilliland F, Celli B, Belinsky SA, Tesfaigzi Y. New Mexican Hispanic smokers have lower odds of chronic obstructive pulmonary disease and less decline in lung function than non-Hispanic whites. American Journal of Respiratory and Critical Care Medicine. 184: 1254-60. PMID 21908412 DOI: 10.1164/Rccm.201103-0568Oc  0.178
1993 Liu Y, Sundqvist K, Belinsky SA, Castonguay A, Tjälve H, Grafström RC. Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in cultured explants and epithelial cells of human buccal mucosa. Carcinogenesis. 14: 2383-8. PMID 8242870 DOI: 10.1093/Carcin/14.11.2383  0.176
2014 Petersen H, Sood A, Meek PM, Shen X, Cheng Y, Belinsky SA, Owen CA, Washko G, Pinto-Plata V, Kelly E, Celli B, Tesfaigzi Y. Rapid lung function decline in smokers is a risk factor for COPD and is attenuated by angiotensin-converting enzyme inhibitor use. Chest. 145: 695-703. PMID 24008986 DOI: 10.1378/Chest.13-0799  0.171
2023 Jiang M, Hu CJ, Rowe CL, Kang H, Gong X, Dagucon CP, Wang J, Lin Y, Sood A, Guo Y, Zhu Y, Alexis NE, Gilliland FD, Belinsky SA, Yu X, et al. Application of artificial intelligence in quantifying lung deposition dose of black carbon in people with exposure to ambient combustion particles. Journal of Exposure Science & Environmental Epidemiology. PMID 37848612 DOI: 10.1038/s41370-023-00607-0  0.17
2021 Bruse S, Moreau M, Bromberg Y, Jang JH, Wang N, Ha H, Picchi M, Lin Y, Langley RJ, Qualls C, Klesney-Tait J, Zabner J, Leng S, Mao J, Belinsky SA, et al. Correction to: Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility. Human Genomics. 15: 74. PMID 34965893 DOI: 10.1186/s40246-021-00373-w  0.169
2020 Devadoss D, Singh SP, Acharya A, Do KC, Periyasamy P, Manevski M, Mishra N, Tellez CS, Ramakrishnan S, Belinsky SA, Byrareddy SN, Buch S, Chand HS, Sopori M. HIV-1 Productively Infects and Integrates in Bronchial Epithelial Cells. Frontiers in Cellular and Infection Microbiology. 10: 612360. PMID 33614527 DOI: 10.3389/fcimb.2020.612360  0.163
2000 Henderson RF, Barr EB, Belinsky SA, Benson JM, Hahn FF, Ménache MG. 1,3-butadiene: cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-diepoxybutane Research Report (Health Effects Institute). PMID 10925838  0.162
2006 Tesfaigzi Y, Myers OB, Stidley CA, Schwalm K, Picchi M, Crowell RE, Gilliland FD, Belinsky SA. Genotypes in matrix metalloproteinase 9 are a risk factor for COPD. International Journal of Chronic Obstructive Pulmonary Disease. 1: 267-78. PMID 18046864 DOI: 10.2147/Copd.2006.1.3.267  0.155
1982 Belinsky SA, Bedell MA, Swenberg JA. Effect of chronic ethanol diet on the replication, alkylation, and repair of DNA from hepatocytes and nonparenchymal cells following dimethylnitrosamine administration. Carcinogenesis. 3: 1293-7. PMID 7151247 DOI: 10.1093/Carcin/3.11.1293  0.153
1997 Neft RE, Murphy MM, Tierney LA, Belinsky SA, Andersen M, Saccomanno G, Michels R, Timm S, Gilliland FD, Crowell RE, Lechner JF. Concurrent fluorescence in situ hybridization and immunocytochemistry for the detection of chromosome aberrations in exfoliated bronchial epithelial cells Acta Cytologica. 41: 1769-1773. DOI: 10.1159/000333183  0.145
1987 Belinsky SA, Walker VE, Maronpot RR, Swenberg JA, Anderson MW. Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia. Cancer Research. 47: 6058-65. PMID 3664508  0.141
2020 Tellez CS, Juri DE, Phillips LM, Do K, Yingling CM, Thomas CL, Dye WW, Wu G, Kishida S, Kiyono T, Belinsky SA. Cytotoxicity and Genotoxicity of E-Cigarette Generated Aerosols Containing Diverse Flavoring Products and Nicotine in Oral Epithelial Cell Lines. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33226417 DOI: 10.1093/toxsci/kfaa174  0.14
1998 Finch GL, March TH, Hahn FF, Barr EB, Belinsky SA, Hoover MD, Lechner JF, Nikula KJ, Hobbs CH. Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic beryllium Toxicologic Pathology. 26: 484-491. PMID 9715507  0.135
1987 Swenberg JA, Richardson FC, Boucheron JA, Deal FH, Belinsky SA, Charbonneau M, Short BG. High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances. Environmental Health Perspectives. 76: 57-63. PMID 3447904  0.13
1987 Belinsky SA, Anderson MW. Tissue and cellular specificity for DNA adduct formation and persistence following in vivo exposure to chemicals Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progres De La Recherche Experimentale Des Tumeurs. 31: 11-20. PMID 3562856  0.127
2015 Petersen H, Leng S, Belinsky SA, Miller BE, Tal-Singer R, Owen CA, Celli B, Tesfaigzi Y. Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis. The European Respiratory Journal. PMID 26160869 DOI: 10.1183/13993003.00682-2015  0.126
2006 Divine KK, Liechty KC, Crume KC, Belinsky SA. Nested multigene MSP/DHPLC method for analyzing promoter hypermethylation status in clinical samples. Biotechniques. 40: 40, 42, 44 passim. PMID 16454038 DOI: 10.2144/000112095  0.117
1982 Belinsky SA, Kauffman FC, Thurman RG. Regulation of mixed-function oxidation of 7-ethoxycoumarin in periportal and pericentral regions of perfused liver from phenobarbital and β-naphthoflavone-treated rats Federation Proceedings. 41: 7610.  0.093
1981 Thurman RG, Reinke LA, Belinsky S, Evans RK, Kauffman FC. Co-regulation of the mixed-function oxidation of p-nitroanisole and glucuronidation of p-nitrophenol in the perfused rat liver by carbohydrate reserves Archives of Biochemistry and Biophysics. 209: 137-142. PMID 7283432 DOI: 10.1016/0003-9861(81)90265-4  0.091
1980 Belinsky SA, Reinke LA, Kauffman FC, Thurman RG. Inhibition of mixed-function oxidation of p-nitroanisole in perfused rat liver by 2,4-dinitrophenol Archives of Biochemistry and Biophysics. 204: 207-213. PMID 7425638  0.086
1983 Reinke LA, Kauffman FC, Belinsky SA, Thurman RG. Inhibition of p-nitroanisole O-demethylation in perfused rat liver by potassium cyanide Archives of Biochemistry and Biophysics. 225: 313-319. PMID 6311107 DOI: 10.1016/0003-9861(83)90035-8  0.086
2021 Scott BR, Lin Y, Saxton B, Chen W, Potter CA, Belinsky SA. Modeling Cell Survival Fraction and Other Dose-Response Relationships for Immunodeficient C.B-17 SCID Mice Exposed to 320-kV X Rays. Dose-Response : a Publication of International Hormesis Society. 19: 15593258211019887. PMID 34104124 DOI: 10.1177/15593258211019887  0.083
1981 Reinke LA, Belinsky SA, Evans RK, Kauffman FC, Thurman RG. Conjugation of p-nitrophenol in the perfused rat liver: The effect of substrate concentration and carbohydrate reserves Journal of Pharmacology and Experimental Therapeutics. 217: 863-870. PMID 6785420  0.081
1984 Reinke LA, Harmon T, Belinsky SA, Kauffman FC, Thurman RG. p-Nitroanisole O-demethylation in perfused hamster liver. High rates of pentose cycle-independent mixed-function oxidation Biochemical Pharmacology. 33: 1315-1321. PMID 6712737 DOI: 10.1016/0006-2952(84)90186-2  0.081
1982 Reinke LA, Belinsky SA, Kauffman FC, Evans RK, Thurman RG. Regulation of NADPH-dependent mixed-function oxidation in perfused livers. Comparative studies with sorbitol and ethanol Biochemical Pharmacology. 31: 1621-1628. PMID 7092954 DOI: 10.1016/0006-2952(82)90390-2  0.077
1983 Thurman RG, Kauffman FC, JI S, Lemasters JJ, Conway JG, Belinsky SA, Kashiwagi T, Matsumura T. Metabolic heterogeneity in the perfused rat liver Pharmacology, Biochemistry and Behavior. 18: 415-419. PMID 6356163 DOI: 10.1016/0091-3057(83)90209-5  0.075
1984 Belinsky SA, Kauffman FC, Thurman RG. Reducing equivalents for mixed function oxidation in periportal and pericentral regions of the liver lobule in perfused livers from normal and phenobarbital-treated rats Molecular Pharmacology. 26: 574-581. PMID 6333582  0.075
1979 Reinke LA, Kauffman FC, Evans RK, Belinsky SA, Thurman RG. p-Nitrophenol conjugation in perfused livers from normal and phenobarbital-treated rats: Influence of nutritional state Research Communications in Chemical Pathology and Pharmacology. 23: 185-193. PMID 108780  0.072
1987 Belinsky SA, Kari FW, Kauffman FC, Thurman RG. Effect of β-naphthoflavone on mitochondrial supply of reducing equivalents for monooxygenation in periportal and pericentral regions of the liver lobule Molecular Pharmacology. 32: 315-320. PMID 3497333  0.067
2022 John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH, Koskela JT, Luan J, Li X, Terzikhan N, Xu H, Bartz TM, Petersen H, ... ... Belinsky SA, et al. Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap. Chest. PMID 35104449 DOI: 10.1016/j.chest.2021.12.674  0.066
2005 Tesfaigzi Y, Myers OB, Stidley CA, Schwalm K, Picchi M, Crowell RE, Gilliland FD, Belinsky SA. Genotypes in matrix metalloproteinase 9 are risk factors for chronic obstructive pulmonary disease Experimental Lung Research. 31: 74-75. PMID 16395864  0.064
1986 Belinsky SA, Badr MZ, Kauffman FC, Thurman RG. Mechanism of hepatotoxicity in periportal regions of the liver lobule due to allyl alcohol: Studies on thiols and energy status Journal of Pharmacology and Experimental Therapeutics. 238: 1132-1137. PMID 3746662  0.064
1980 Reinke LA, Kauffman FC, Belinsky SA, Thurman RG. Interactions between ethanol metabolism and mixed-function oxidation in perfused rat liver: Inhibition of p-nitroanisole O-demethylation Journal of Pharmacology and Experimental Therapeutics. 213: 70-78. PMID 6987376  0.064
1986 Badr MZ, Belinsky SA, Kauffman FC, Thurman RG. Mechanism of hepatotoxicity to periportal regions of the liver lobule due to allyl alcohol: Role of oxygen and lipid peroxidation Journal of Pharmacology and Experimental Therapeutics. 238: 1138-1142. PMID 3755756  0.064
2020 Zhou Y, Irshad H, Dye WW, Wu G, Tellez CS, Belinsky SA. Voltage and e-liquid composition affect nicotine deposition within the oral cavity and carbonyl formation. Tobacco Control. PMID 32587113 DOI: 10.1136/tobaccocontrol-2020-055619  0.063
1984 Thurman RG, Kauffman FC, Belinsky SA. Mixed function oxidation of 7-ethoxycoumarin in β-naphthoflavone treated rats: Sources of reducing equivalents in periportal and pericentral regions of the liver lobule Federation Proceedings. 43.  0.063
1984 Belinsky SA, Kauffman FC, Sokolove PM, Tsukuda T, Thurman RG. Calcium-mediated inhibition of glucuronide production by epinephrine in the perfused rat liver Journal of Biological Chemistry. 259: 7705-7711. PMID 6330073  0.062
1980 Kauffman FC, Evans RK, Reinke LA, Belinsky SA, Ballow C, Thurman RG. Effects of 3-methylcholanthrene on oxidized nicotinamide-adenine dinucleotide phosphatedependent dehydrogenases and selected metabolites in perfused rat liver Biochemical Pharmacology. 29: 697-700. PMID 20227942 DOI: 10.1016/0006-2952(80)90542-0  0.062
1983 Belinsky SA, Kauffman FC, Ji S, Lemasters JJ, Thurman RG. Stimulation of mixed-function oxidation of 7-ethoxycoumarin in periportal and pericentral regions of the perfused rat liver by xylitol European Journal of Biochemistry. 137: 1-6. PMID 6606574 DOI: 10.1111/J.1432-1033.1983.Tb07787.X  0.061
1989 Belinsky SA, Kauffman FC, Thurman RG. Interactions between glycolysis and mixed function oxidation: Studies with 7-ethoxycoumarin in perfused livers from β-naphthoflavone-treated rats Molecular Pharmacology. 35: 512-518. PMID 2704372  0.061
1983 Reinke LA, Kauffman FC, Belinsky SA, Thurman RG. Effects of ethanol and sorbitol on mixed-function oxidation in perfused rat livers Pharmacology, Biochemistry and Behavior. 18: 289-294. PMID 6634842 DOI: 10.1016/0091-3057(83)90188-0  0.058
1984 Belinsky SA, Popp JA, Kauffman FC, Thurman RG. Trypan blue uptake as a new method to investigate hepatotoxicity in periportal and pericentral regions of the liver lobule: Studies with allyl alcohol in the perfused liver Journal of Pharmacology and Experimental Therapeutics. 230: 755-760. PMID 6470978  0.057
1979 Reinke LA, Ballow C, Belinsky SA. Effect of benzo(a)pyrene on intermediary metabolism in isolated perfused rat livers Federation Proceedings. 38.  0.056
1981 Belinsky SA, Reinke LA, Kauffman FC. Metabolism of p-nitroanisole in perfused rat liver in absence of NADPH generation from the pentose phosphate shunt Federation Proceedings. 40: 2874.  0.056
1991 Brown PC, Thurman RG, Belinsky SA, Kauffman FC. Effect of allyl alcohol on xanthine dehydrogenase activity in the perfused rat liver Toxicology Letters. 58: 1-6. PMID 1897001 DOI: 10.1016/0378-4274(91)90183-7  0.055
1985 Belinsky SA, Reinke LA, Scholz R, Kauffman FC, Thurman RG. Rates of pentose cycle flux in perfused rat liver: Evaluation of the role of reducing equivalents from the pentose cycle for mixed-function oxidation Molecular Pharmacology. 28: 371-376. PMID 4058419  0.054
1980 Reinke LA, Belinsky SA, Kauffman FC, Thurman RG. Mechanism of inhibition of mixed-function oxidation by ethanol Advances in Experimental Medicine and Biology. 132: 151-161. PMID 7424703 DOI: 10.1007/978-1-4757-1419-7_16  0.05
2011 Belinsky SB, Blagg JD. Analyzing the glass ceiling effect among radiologic technologists. Radiologic Technology. 82: 300-10. PMID 21406707  0.049
2013 Liu Y, Nyunoya T, Leng S, Belinsky SA, Tesfaigzi Y, Bruse S. Softwares and methods for estimating genetic ancestry in human populations. Human Genomics. 7: 1. PMID 23289408 DOI: 10.1186/1479-7364-7-1  0.042
1984 Belinsky SA, Matsumura T, Kauffman FC, Thurman RG. Rates of allyl alcohol metabolism in periportal and pericentral regions of the liver lobule Molecular Pharmacology. 25: 158-164. PMID 6708931  0.042
1979 Reinke LA, Kauffman FC, Belinsky SA, Thurman RG. Mechanism of the inhibition of mixed-function oxidation by ethanol Alcoholism: Clinical and Experimental Research. 3: 264.  0.039
1991 Belinsky SB. Teaching students using incremental skill format Radiologic Technology. 62: 288-294. PMID 2027951  0.036
1984 Belinsky SA, Kauffman FC, Thurman RG. Mixed-function oxidation of 7-ethoxycoumarin in β-naphthoflavone treated rats: Interaction with glycolysis Federation Proceedings. 43.  0.032
2007 Belinsky SB, Tataronis GR. Past experiences of the clinical instructor and current attitudes toward evaluation of students. Journal of Allied Health. 36: 11-6. PMID 17425186  0.026
2003 Belinsky SB, Garcia N, Keech FK, Matelli GO. Towards breaking the barriers: The professionalization of the radiologic sciences Journal of Allied Health. 32: 252-255.  0.023
1985 Belinsky SA, Bradford BU, Forman DT, Glassman EB, Felder MR, Thurman RG. Hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase Hepatology. 5: 1179-1182. PMID 2933316 DOI: 10.1002/Hep.1840050619  0.02
1984 Sokolove PM, Tsukuda T, Belinsky S. Stimulation of hepatic microsomal β-glucuronidase by calcium Federation Proceedings. 43.  0.01
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