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Christopher Winslow Akey - Publications

Affiliations: 
Boston University School of Medicine, Boston, MA 
Area:
cryo-electron microscopy
Website:
http://www.bumc.bu.edu/phys-biophys/people/faculty/akey/
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Dorstyn L, Akey CW, Kumar S. New insights into apoptosome structure and function. Cell Death and Differentiation. PMID 29765111 DOI: 10.1038/S41418-017-0025-Z  0.447
2018 Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, ... ... Akey CW, et al. Integrative structure and functional anatomy of a nuclear pore complex. Nature. 555: 475-482. PMID 29539637 DOI: 10.1017/S1431927618006542  0.404
2018 Joong Kim S, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Upla P, Chemmama IE, Pellarin R, Echeverria I, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP. Structure and Functional Anatomy of the Nuclear Pore Complex Biophysical Journal. 114: 372a. DOI: 10.1016/J.Bpj.2017.11.2063  0.377
2017 Mendez DL, Akey IV, Akey CW, Kranz RG. Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro. Biochemistry. 56: 2766-2769. PMID 28510448 DOI: 10.1021/Acs.Biochem.7B00309  0.337
2017 Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW. A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. Structure (London, England : 1993). 25: 40-52. PMID 27916517 DOI: 10.1016/J.Str.2016.11.002  0.643
2016 Cheng TC, Hong C, Akey IV, Yuan S, Akey CW. A near atomic structure of the active human apoptosome. Elife. 5. PMID 27697150 DOI: 10.7554/Elife.17755  0.662
2016 Cheng TC, Hong C, Akey IV, Yuan S, Akey CW. Author response: A near atomic structure of the active human apoptosome Elife. DOI: 10.7554/Elife.17755.030  0.55
2014 Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 506: 102-6. PMID 24153188 DOI: 10.1038/Nature12720  0.365
2013 D'Brot A, Chen P, Vaishnav M, Yuan S, Akey CW, Abrams JM. Tango7 directs cellular remodeling by the Drosophila apoptosome. Genes & Development. 27: 1650-5. PMID 23913920 DOI: 10.1101/Gad.219287.113  0.573
2013 Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure (London, England : 1993). 21: 1361-73. PMID 23850453 DOI: 10.1016/J.Str.2013.05.017  0.774
2013 Yuan S, Akey CW. Apoptosome structure, assembly, and procaspase activation. Structure (London, England : 1993). 21: 501-15. PMID 23561633 DOI: 10.1016/J.Str.2013.02.024  0.661
2013 Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW. Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry. 52: 2319-27. PMID 23521171 DOI: 10.1021/Bi301721G  0.669
2011 Platonova O, Akey IV, Head JF, Akey CW. Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry. 50: 8078-89. PMID 21863821 DOI: 10.1021/Bi2006652  0.428
2011 Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW. The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure (London, England : 1993). 19: 1084-96. PMID 21827945 DOI: 10.1016/J.Str.2011.07.001  0.702
2011 Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW. Structure of the Drosophila apoptosome at 6.9 å resolution. Structure (London, England : 1993). 19: 128-40. PMID 21220123 DOI: 10.1016/J.Str.2010.10.009  0.751
2011 Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW. Structure of the Drosophila apoptosome at 6.9 angstrom resolution Structure. 19: 128-140. DOI: 10.2210/Pdb4V4L/Pdb  0.689
2010 Akey CW. The NPC-transporter, a ghost in the machine. Structure (London, England : 1993). 18: 1230-2. PMID 20947011 DOI: 10.1016/J.Str.2010.09.005  0.309
2010 Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW. Structure of an apoptosome-procaspase-9 CARD complex. Structure (London, England : 1993). 18: 571-83. PMID 20462491 DOI: 10.1016/J.Str.2010.04.001  0.735
2009 Raychaudhury S, Farelli JD, Montminy TP, Matthews M, Ménétret JF, Duménil G, Roy CR, Head JF, Isberg RR, Akey CW. Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure (London, England : 1993). 17: 590-601. PMID 19368892 DOI: 10.1016/J.Str.2009.02.011  0.77
2008 Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW. Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (London, England : 1993). 16: 1126-37. PMID 18611385 DOI: 10.1016/J.Str.2008.05.003  0.375
2008 Chandramouli P, Topf M, Ménétret JF, Eswar N, Cannone JJ, Gutell RR, Sali A, Akey CW. Structure of the mammalian 80S ribosome at 8.7 A resolution. Structure (London, England : 1993). 16: 535-48. PMID 18400176 DOI: 10.1016/J.Str.2008.01.007  0.403
2007 Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW. Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Molecular Cell. 28: 1083-92. PMID 18158904 DOI: 10.1016/J.Molcel.2007.10.034  0.422
2006 Yu X, Wang L, Acehan D, Wang X, Akey CW. Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. Journal of Molecular Biology. 355: 577-89. PMID 16310803 DOI: 10.1016/J.Jmb.2005.10.040  0.793
2005 Yu X, Acehan D, Ménétret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW. A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (London, England : 1993). 13: 1725-35. PMID 16271896 DOI: 10.1016/J.Str.2005.09.006  0.799
2005 Ménétret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW. Architecture of the ribosome-channel complex derived from native membranes. Journal of Molecular Biology. 348: 445-57. PMID 15811380 DOI: 10.1016/J.Jmb.2005.02.053  0.392
2004 Namboodiri VM, Schmidt-Zachmann MS, Head JF, Akey CW. Purification, crystallization and preliminary X-ray analysis of the N-terminal domain of NO38, a nucleolar protein from Xenopus laevis. Acta Crystallographica. Section D, Biological Crystallography. 60: 2325-7. PMID 15583381 DOI: 10.1107/S0907444904023959  0.41
2004 Namboodiri VM, Akey IV, Schmidt-Zachmann MS, Head JF, Akey CW. The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus. Structure (London, England : 1993). 12: 2149-60. PMID 15576029 DOI: 10.1016/J.Str.2004.09.017  0.335
2004 Clemons WM, Ménétret JF, Akey CW, Rapoport TA. Structural insight into the protein translocation channel. Current Opinion in Structural Biology. 14: 390-6. PMID 15313231 DOI: 10.1016/J.Sbi.2004.07.006  0.423
2004 Acehan D, Yu X, Wang L, Jiang X, Booth CR, Wang X, Akey CW. Structures of the human and Drosophila apoptosome determined by single particle electron cryo-microscopy Microscopy and Microanalysis. 10: 230-231. DOI: 10.1017/S1431927604883090  0.737
2003 Akey CW, Luger K. Histone chaperones and nucleosome assembly. Current Opinion in Structural Biology. 13: 6-14. PMID 12581654 DOI: 10.1016/S0959-440X(03)00002-2  0.31
2003 Namboodiri VM, Dutta S, Akey IV, Head JF, Akey CW. The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding. Structure (London, England : 1993). 11: 175-86. PMID 12575937 DOI: 10.1016/S0969-2126(03)00007-8  0.585
2002 Morgan DG, Ménétret JF, Neuhof A, Rapoport TA, Akey CW. Structure of the mammalian ribosome-channel complex at 17A resolution. Journal of Molecular Biology. 324: 871-86. PMID 12460584 DOI: 10.1016/S0022-2836(02)01111-7  0.365
2002 Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Molecular Cell. 9: 423-32. PMID 11864614 DOI: 10.1016/S1097-2765(02)00442-2  0.768
2001 Dutta S, Akey IV, Dingwall C, Hartman KL, Laue T, Nolte RT, Head JF, Akey CW. The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly. Molecular Cell. 8: 841-53. PMID 11684019 DOI: 10.1016/S1097-2765(01)00354-9  0.586
2000 Menetret JF, Neuhof A, Morgan DG, Plath K, Radermacher M, Rapoport TA, Akey CW. The structure of ribosome-channel complexes engaged in protein translocation. Molecular Cell. 6: 1219-32. PMID 11106759 DOI: 10.1016/S1097-2765(00)00118-0  0.338
2000 Morgan DG, Ménétret JF, Radermacher M, Neuhof A, Akey IV, Rapoport TA, Akey CW. A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments. Journal of Molecular Biology. 301: 301-21. PMID 10926511 DOI: 10.1006/Jmbi.2000.3947  0.403
2000 Ménétret J, Morgan DG, Radermacher M, Neuhof A, Rapoport TA, Akey CW. Three-Dimensional Structure of Ribosome-Sec61p Translocation Complexes From Mammals Microscopy and Microanalysis. 6: 264-265. DOI: 10.1017/S143192760003381X  0.401
1999 Meyer TH, Ménétret JF, Breitling R, Miller KR, Akey CW, Rapoport TA. The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex. Journal of Molecular Biology. 285: 1789-800. PMID 9917412 DOI: 10.1006/Jmbi.1998.2413  0.414
1998 Yang Q, Rout MP, Akey CW. Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Molecular Cell. 1: 223-34. PMID 9659919 DOI: 10.1016/S1097-2765(00)80023-4  0.375
1998 Yang Q, Ménétret J, Akey IV, Plath K, Rapoport TA, Akey CW. Structural Studies of Translocation Channels: The Nuclear Pore Complex and the Translocon Microscopy and Microanalysis. 4: 960-961. DOI: 10.1017/S1431927600024922  0.346
1997 Bullitt E, Rout MP, Kilmartin JV, Akey CW. The yeast spindle pole body is assembled around a central crystal of Spc42p. Cell. 89: 1077-86. PMID 9215630 DOI: 10.1016/S0092-8674(00)80295-0  0.373
1996 Hanein D, Matlack KE, Jungnickel B, Plath K, Kalies KU, Miller KR, Rapoport TA, Akey CW. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation. Cell. 87: 721-32. PMID 8929540 DOI: 10.1016/S0092-8674(00)81391-4  0.401
1995 Akey CW. Structural plasticity of the nuclear pore complex Journal of Molecular Biology. 248: 273-293. PMID 7739040 DOI: 10.1016/S0022-2836(95)80050-6  0.404
1993 Akey CW, Radermacher M. Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy Journal of Cell Biology. 122: 1-19. PMID 8314837 DOI: 10.1083/Jcb.122.1.1  0.424
1990 Akey CW. Visualization of transport-related configurations of the nuclear pore transporter Biophysical Journal. 58: 341-355. PMID 2207242 DOI: 10.1016/S0006-3495(90)82381-X  0.321
1989 Akey CW. Interactions and structure of the nuclear pore complex revealed by cryo-electron microscopy Journal of Cell Biology. 109: 955-970. PMID 2768344 DOI: 10.1083/Jcb.109.3.955  0.425
1989 Akey CW, Goldfarb DS. Protein import through the nuclear pore complex is a multistep process Journal of Cell Biology. 109: 971-982. PMID 2475512 DOI: 10.1083/Jcb.109.3.971  0.365
1987 Akey CW, Crepeau RH, Edelstein SJ. The innermost chorionic layer of Drosophila. II. Three-dimensional structure determination of the 90 ° crystal form by electron microscopy Journal of Molecular Biology. 193: 685-692. PMID 3112411 DOI: 10.1016/0022-2836(87)90351-2  0.661
1987 Akey CW, Edelstein SJ. The innermost chorionic layer of Drosophila. I. The role of chorin octamers in the formation of a family of interdigitating crystalline plates Journal of Molecular Biology. 193: 673-683. PMID 3112410 DOI: 10.1016/0022-2836(87)90350-0  0.646
1986 Akey CW, Dunn SD, Spitsberg V, Edelstein SJ. Electron microscopy of single molecules and crystals of F1-ATPases Methods in Enzymology. 434-446. PMID 2908457 DOI: 10.1016/S0076-6879(86)26043-7  0.622
1984 Akey CW, Szalay M, Edelstein SJ. Trigonal catalase crystals: a new molecular packing assignment obtained from sections preserved with tannic acid. Ultramicroscopy. 13: 103-11. PMID 6474594 DOI: 10.1016/0304-3991(84)90061-5  0.615
1984 Akey CW, Szalay M, Edelstein SJ. Trigonal catalase crystals: A new molecular packing assignment obtained from sections preserved with tannic acid Ultramicroscopy. 13: 103-111. DOI: 10.1016/0304-3991(84)90061-5  0.532
1983 Akey CW, Crepeau RH, Dunn SD, McCarty RE, Edelstein SJ. Electron microscopy and single molecule averaging of subunit-deficient F1-ATPases from Escherichia coli and spinach chloroplasts. Embo Journal. 2: 1409-1415. PMID 10872338 DOI: 10.1002/J.1460-2075.1983.Tb01599.X  0.607
1983 Akey CW, Edelstein SJ. Equivalence of the projected structure of thin catalase crystals preserved for electron microscopy by negative stain, glucose or embedding in the presence of tannic acid Journal of Molecular Biology. 163: 575-612. PMID 6842587 DOI: 10.1016/0022-2836(83)90113-4  0.623
1983 Akey CW, Spitsberg V, Edelstein SJ. Electron microscopy of beef heart F1-ATPase crystals. Journal of Biological Chemistry. 258: 3222-3229. PMID 6219110  0.6
1980 Akey CW, Moffat K, Wharton DC, Edelstein SJ. Characterization of crystals of a cytochrome oxidase (nitrite reductase) from Pseudomonas aeruginosa by X-ray diffraction and electron microscopy Journal of Molecular Biology. 136: 19-43. PMID 6245219 DOI: 10.1016/0022-2836(80)90364-2  0.627
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