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Christopher D. Willey, Ph.D. - Publications

Affiliations: 
2003 Medical University of South Carolina, Charleston, SC, United States 
Area:
Cell Biology, Molecular Biology
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zeng L, Boggs DH, Xing C, Zhang Z, Anderson JC, Wajapeyee N, Veale C, Bredel M, Shi LZ, Bonner JA, Willey CD, Yang ES. Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. Frontiers in Genetics. 11: 1036. PMID 33133138 DOI: 10.3389/Fgene.2020.01036  0.314
2020 Chandrashekar DS, Chakravarthi BVSK, Robinson AD, Anderson JC, Agarwal S, Balasubramanya SAH, Eich ML, Bajpai AK, Davuluri S, Guru MS, Guru AS, Naik G, Della Manna DL, Acharya KK, Carskadon S, ... ... Willey CD, et al. Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression. Oncogene. PMID 32231273 DOI: 10.1038/S41388-020-1275-7  0.428
2020 Nair S, Trummell HQ, Rajbhandari R, Thudi NK, Nozell SE, Warram JM, Willey CD, Yang ES, Placzek WJ, Bonner JA, Bredel M. Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer. Plos One. 15: e0229077. PMID 32069320 DOI: 10.1371/Journal.Pone.0229077  0.301
2019 Ibrahim AN, Yamashita D, Anderson JC, Abdelrashid M, Alwakeal A, Estevez-Ordonez D, Komarova S, Markert JM, Goidts V, Willey CD, Nakano I. Intratumoral spatial heterogeneity of BTK kinomic activity dictates distinct therapeutic response within a single glioblastoma tumor. Journal of Neurosurgery. 1-12. PMID 31628288 DOI: 10.3171/2019.7.Jns191376  0.327
2019 Aye JM, Stafman LL, Williams AP, Garner EF, Stewart JE, Anderson JC, Mruthyunjayappa S, Waldrop MG, Goolsby CD, Markert HR, Quinn C, Marayati R, Mroczek-Musulman E, Willey CD, Yoon KJ, et al. The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor. Oncotarget. 10: 5534-5548. PMID 31565187 DOI: 10.18632/Oncotarget.27165  0.401
2019 Eustace NJ, Anderson JC, Langford CP, Trummell HQ, Hicks PH, Jarboe JS, Mobley JA, Hjelmeland AB, Hackney JR, Pedersen RT, Cosby K, Gillespie GY, Bonner JA, Willey CD. Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. International Journal of Oncology. PMID 30942445 DOI: 10.3892/Ijo.2019.4766  0.454
2019 Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, et al. Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and metastasis in breast cancer. Cancer Research. PMID 30733195 DOI: 10.1158/0008-5472.Can-18-2636  0.372
2018 Dussaq AM, Kennell T, Eustace NJ, Anderson JC, Almeida JS, Willey CD. Kinomics toolbox-A web platform for analysis and viewing of kinomic peptide array data. Plos One. 13: e0202139. PMID 30130366 DOI: 10.1371/Journal.Pone.0202139  0.304
2018 Walker K, Boyd NH, Anderson JC, Willey CD, Hjelmeland AB. Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose. Biomarker Research. 6: 22. PMID 29946469 DOI: 10.1186/S40364-018-0136-9  0.316
2018 Gilbert AN, Anderson JC, Duarte CW, Shevin RS, Langford CP, Singh R, Gillespie GY, Willey CD. Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions. Scientific Reports. 8: 8412. PMID 29849102 DOI: 10.1038/S41598-018-26840-4  0.362
2018 Britain CM, Holdbrooks AT, Anderson JC, Willey CD, Bellis SL. Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death. Journal of Ovarian Research. 11: 12. PMID 29402301 DOI: 10.1186/S13048-018-0385-0  0.325
2017 Rohrbach TD, Jones RB, Hicks PH, Weaver AN, Cooper TS, Eustace NJ, Yang ES, Jarboe JS, Anderson JC, Willey CD. MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines. Oncology Letters. 13: 1216-1222. PMID 28454237 DOI: 10.3892/Ol.2016.5550  0.399
2017 Yang ES, Willey CD, Mehta A, Crowley MR, Crossman DK, Chen D, Anderson JC, Naik G, Della Manna DL, Cooper TS, Sonpavde G. Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets. Oncotarget. 8: 21710-21718. PMID 28423512 DOI: 10.18632/Oncotarget.15558  0.433
2017 Ghosh AP, Willey CD, Anderson JC, Welaya K, Chen D, Mehta A, Ghatalia P, Madan A, Naik G, Sudarshan S, Sonpavde G. Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma. Oncotarget. PMID 28418903 DOI: 10.18632/Oncotarget.16352  0.426
2017 Eustace N, Anderson J, Langford C, Hicks P, Hjelmeland A, Willey C, Jarboe J. CSIG-10. MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE PHOSPHORYLATION ENHANCES THE GROWTH AND RADIATION RESISTANCE OF GLIOBLASTOMA Neuro-Oncology. 19: vi51-vi52. DOI: 10.1093/Neuonc/Nox168.205  0.403
2016 Dussaq A, Anderson JC, Willey CD, Almeida JS. Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays. Journal of Proteomics & Bioinformatics. 9: 151-157. PMID 27601856 DOI: 10.4172/Jpb.1000401  0.395
2016 Gilbert AN, Shevin RS, Anderson JC, Langford CP, Eustace N, Gillespie GY, Singh R, Willey CD. Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing. Journal of Visualized Experiments : Jove. PMID 27341166 DOI: 10.3791/54026  0.3
2016 Lohiya V, Willey C, Yang ES, Crowley M, Anderson J, Della Manna DL, Naik G, Crossman D, Varambally S, Chandrashekar DS, Sonpavde G. Multiplatform comprehensive kinase analysis of muscle-invasive bladder cancer (MIBC) to identify potentially actionable therapeutic targets. Journal of Clinical Oncology. 34: e16014-e16014. DOI: 10.1200/Jco.2016.34.15_Suppl.E16014  0.397
2015 Anderson JC, Taylor RB, Fiveash JB, de Wijn R, Gillespie GY, Willey CD. KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA. Medical Research Archives. 2015. PMID 27158663 DOI: 10.18103/Mra.V0I3.104  0.389
2015 Rohrbach TD, Shah N, Jackson WP, Feeney EV, Scanlon S, Gish R, Khodadadi R, Hyde SO, Hicks PH, Anderson JC, Jarboe JS, Willey CD. The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. Plos One. 10: e0140870. PMID 26470026 DOI: 10.1371/Journal.Pone.0140870  0.309
2015 Bonner JA, Trummell HQ, Bonner AB, Willey CD, Bredel M, Yang ES. Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition. Bmc Cancer. 15: 673. PMID 26458879 DOI: 10.1186/S12885-015-1679-X  0.316
2015 Anderson JC, Willey CD, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes. Plos One. 10: e0139267. PMID 26406598 DOI: 10.1371/Journal.Pone.0139267  0.389
2015 Willey CD, Gilbert AN, Anderson JC, Gillespie GY. Patient-Derived Xenografts as a Model System for Radiation Research. Seminars in Radiation Oncology. 25: 273-80. PMID 26384275 DOI: 10.1016/J.Semradonc.2015.05.008  0.312
2015 Palanisamy AP, Suryakumar G, Panneerselvam K, Willey CD, Kuppuswamy D. A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium. Journal of Cellular Biochemistry. 116: 2793-803. PMID 25976166 DOI: 10.1002/Jcb.25224  0.748
2015 Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD. Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. International Journal of Oncology. 46: 1079-88. PMID 25524703 DOI: 10.3892/Ijo.2014.2799  0.397
2015 Mehta AN, Yang ES, Willey CD, Crowley M, Chen D, Anderson J, Naik G, Cooper T, Sonpavde G. Multiplatform comprehensive kinase analysis of penile squamous cell carcinoma (PSCC) to identify drivers and potentially actionable therapeutic targets. Journal of Clinical Oncology. 33: 389-389. DOI: 10.1200/Jco.2015.33.7_Suppl.389  0.425
2015 Bredel M, Ferrarese R, Thudi NK, Puliyappadamba VK, Bug E, Trummell H, Anderson J, Willey CD, Yang ES, Beck W, Bonner JA, Carro M. Targeting PTBP1 as a therapeutic strategy to reverse lineage-specific splicing of ANXA7 and ensuing EGFR activation in glioblastoma. Journal of Clinical Oncology. 33: 2075-2075. DOI: 10.1200/Jco.2015.33.15_Suppl.2075  0.311
2015 Rohrbach TD, Hull TD, Jarboe JS, Eustace N, Wang Y, Deshane JS, Willey CD. Abstract A87: Myristoylated alanine rich C-kinase substrate (MARCKS) expression in lung cancer cells influences immune cell populations in tumor microenvironment in murine models Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-A87  0.32
2015 Willey CD, Gilbert AN, Shevin R, Langford CP, Duarte CW, Singh R, Anderson JC, Gillespie GY. Abstract A16: Combinatorial drug testing using 3D microtumors derived from GBM PDX reveals cytotoxic synergisms in pharmacokinomics-informed pathway interactions Brain. 75. DOI: 10.1158/1538-7445.Brain15-A16  0.34
2015 Willey CD, Gilbert AN, Shevin R, Langford CP, Singh R, Anderson JC, Gillespie GY. Abstract 312: Profiling drug sensitivity and kinomic pathways utilizing a novel human tumor derived MicroTumor assay Cancer Research. 75: 312-312. DOI: 10.1158/1538-7445.Am2015-312  0.375
2015 Bredel M, Ferrarese R, Thudi N, Puliyappadamba V, Bug E, Trummell H, Anderson J, Willey C, Yang E, Beck W, Bonner J, Carro M. Targeting of PTBP1 Reverses Lineage Specific Splicing of the Tumor Suppressor ANXA7 and Oncogenic EGFR Signaling in Glioblastoma International Journal of Radiation Oncology*Biology*Physics. 93: S48. DOI: 10.1016/J.Ijrobp.2015.07.117  0.306
2014 Anderson JC, Minnich DJ, Dobelbower MC, Denton AJ, Dussaq AM, Gilbert AN, Rohrbach TD, Arafat W, Welaya K, Bonner JA, Willey CD. Kinomic profiling of electromagnetic navigational bronchoscopy specimens: a new approach for personalized medicine. Plos One. 9: e116388. PMID 25549342 DOI: 10.1371/Journal.Pone.0116388  0.349
2014 Sonpavde G, Willey CD, Sudarshan S. Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma. Expert Opinion On Investigational Drugs. 23: 305-15. PMID 24387233 DOI: 10.1517/13543784.2014.871259  0.315
2014 Mehta AN, Willey CD, Anderson J, Welaya KY, Chen D, Ghatalia P, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. Comprehensive kinase profiling to classify clear cell (cc)-renal cell carcinoma (RCC). Journal of Clinical Oncology. 32: 409-409. DOI: 10.1200/Jco.2014.32.4_Suppl.409  0.413
2014 Mehta AN, Willey C, Crowley M, Anderson J, Chen D, Crossman D, Necchi A, Lorenzo Gd, Eigl BJ, Lee RJ, Harshman LC, Dorff TB, Galsky MD, Milowsky MI, Bolger G, et al. Integrated comprehensive high-throughput kinomics profiling and whole exome sequencing of penile squamous cell cancer (PSCC). Journal of Clinical Oncology. 32: 383-383. DOI: 10.1200/Jco.2014.32.4_Suppl.383  0.359
2014 Mehta AN, Willey CD, Anderson J, Welaya KY, Chen D, Ghatalia P, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. Comprehensive functional kinase profiling to classify clear cell (cc)-renal cell carcinoma (RCC). Journal of Clinical Oncology. 32: 4572-4572. DOI: 10.1200/Jco.2014.32.15_Suppl.4572  0.379
2014 Willey CD, Crowley M, Chen D, Anderson J, Mgbemena ON, Crossman D, Naik G, Grizzle WE, Sonpavde G. Identification of potentially targetable kinases by concurrent high-throughput functional kinomics and RNA-sequencing (seq) of muscle-invasive bladder cancer (MIBC). Journal of Clinical Oncology. 32: 4553-4553. DOI: 10.1200/Jco.2014.32.15_Suppl.4553  0.366
2013 Jarboe JS, Dutta S, Velu SE, Willey CD. Mini-review: bmx kinase inhibitors for cancer therapy. Recent Patents On Anti-Cancer Drug Discovery. 8: 228-38. PMID 23198769 DOI: 10.2174/15748928113089990043  0.388
2013 Rohrbach TD, Deshane JS, Steele C, Willey CD. Abstract B93: The influence of macrophage stimulation on lung cancer migration/invasion, proliferation, and treatment sensitivity. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-B93  0.3
2013 Arafat W, Anderson J, Welaya K, Willey C, Gillespie Y, Buchsbaum D. Triple Therapy Using Radiation Therapy (RT), Temozolomide (TMZ), and TRAIL Agonist (TRA-8) Enhances Cell Killing in Primary Glioma Cancer Stem Cells Associated With Changes in Distinct Tyrosine Kinase Signaling Cascades Identified Through Kinomic Analysis International Journal of Radiation Oncology*Biology*Physics. 87: S140. DOI: 10.1016/J.Ijrobp.2013.06.361  0.368
2011 Bonner JA, Yang ES, Trummell HQ, Nowsheen S, Willey CD, Raisch KP. Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 99: 339-43. PMID 21704410 DOI: 10.1016/J.Radonc.2011.05.070  0.332
2010 Willey CD, Xiao D, Tu T, Kim KW, Moretti L, Niermann KJ, Tawtawy MN, Quarles CC, Lu B. Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation. International Journal of Radiation Oncology, Biology, Physics. 77: 1518-26. PMID 19906497 DOI: 10.1016/J.Ijrobp.2009.06.044  0.427
2010 Jarboe J, Chiu S, Anderson J, Whitley A, Willey C. Myristoylated Alanine Rich C-kinase Substrate (MARCKS) Can Regulate Glioma Cell Migration, Proliferation, and Radiation Sensitivity International Journal of Radiation Oncology*Biology*Physics. 78: S646. DOI: 10.1016/J.Ijrobp.2010.07.1504  0.415
2009 Bonner JA, Trummell HQ, Willey CD, Plants BA, Raisch KP. Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 92: 339-44. PMID 19616333 DOI: 10.1016/J.Radonc.2009.06.022  0.345
2009 Moretti L, Kim KW, Jung DK, Willey CD, Lu B. Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor. Molecular Cancer Therapeutics. 8: 1270-9. PMID 19417149 DOI: 10.1158/1535-7163.Mct-08-0893  0.309
2008 Willey CD, Palanisamy AP, Johnston RK, Mani SK, Shiraishi H, Tuxworth WJ, Zile MR, Balasubramanian S, Kuppuswamy D. STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMX. International Journal of Biological Sciences. 4: 184-99. PMID 18612371 DOI: 10.7150/Ijbs.4.184  0.758
2008 Tu T, Thotala D, Geng L, Hallahan DE, Willey CD. Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium. Cancer Research. 68: 2861-9. PMID 18413754 DOI: 10.1158/0008-5472.Can-07-5743  0.409
2007 Cuneo KC, Tu T, Geng L, Fu A, Hallahan DE, Willey CD. HIV protease inhibitors enhance the efficacy of irradiation. Cancer Research. 67: 4886-93. PMID 17510418 DOI: 10.1158/0008-5472.Can-06-3684  0.324
2007 Albert JM, Cao C, Kim KW, Willey CD, Geng L, Xiao D, Wang H, Sandler A, Johnson DH, Colevas AD, Low J, Rothenberg ML, Lu B. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 3033-42. PMID 17505006 DOI: 10.1158/1078-0432.Ccr-06-2872  0.328
2007 Kim KW, Mutter RW, Willey CD, Subhawong TK, Shinohara ET, Albert JM, Ling G, Cao C, Gi YJ, Lu B. Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests. International Journal of Radiation Oncology, Biology, Physics. 67: 1519-25. PMID 17394948 DOI: 10.1016/J.Ijrobp.2006.12.018  0.344
2007 Yu K, Ma P, Ge J, Willey CD, Yang P, Wang Z, Gao Q. Expression of protein kinase C isoforms in cultured human retinal pigment epithelial cells. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fã¼R Klinische Und Experimentelle Ophthalmologie. 245: 993-9. PMID 17124607 DOI: 10.1007/S00417-006-0467-3  0.369
2007 Willey C, Tu T, Rao V, Cuneo K, Lu B, Hallahan D. PKC(epsilon) Regulates Radiation Induced Akt Activation via Myristoylated Alanine Rich C Kinase Substrate (MARCKS) in Vascular Endothelium International Journal of Radiation Oncology*Biology*Physics. 69: S101. DOI: 10.1016/J.Ijrobp.2007.07.185  0.416
2006 Balasubramanian S, Mani S, Shiraishi H, Johnston RK, Yamane K, Willey CD, Cooper G, Tuxworth WJ, Kuppuswamy D. Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. Journal of Molecular and Cellular Cardiology. 41: 669-79. PMID 16928382 DOI: 10.1016/J.Yjmcc.2006.04.022  0.655
2006 Palanisamy AP, Willey CD, Kuppuswamy D. A82. Bmx and c-Src mediates phosphorylation of p130Cas during cardiac hypertrophy Journal of Molecular and Cellular Cardiology. 40: 891. DOI: 10.1016/J.Yjmcc.2006.03.360  0.734
2005 Willey C, Geng L, Fu A, Osusky K, Hallahan D. Specific Inhibition of p110δ Catalytic Subunit of Phosphatidylinositol 3’-Kinase With IC489666 Radiosensitizes Vascular Endothelium to Provide Improved Tumor Control International Journal of Radiation Oncology*Biology*Physics. 63: S170-S171. DOI: 10.1016/J.Ijrobp.2005.07.293  0.344
2003 Willey CD, Balasubramanian S, Rodríguez Rosas MC, Ross RS, Kuppuswamy D. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. Journal of Molecular and Cellular Cardiology. 35: 671-83. PMID 12788385 DOI: 10.1016/S0022-2828(03)00112-3  0.68
2002 Iijima Y, Laser M, Shiraishi H, Willey CD, Sundaravadivel B, Xu L, McDermott PJ, Kuppuswamy D. c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells. The Journal of Biological Chemistry. 277: 23065-75. PMID 11940578 DOI: 10.1074/Jbc.M200328200  0.712
2000 Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D. Integrin activation and focal complex formation in cardiac hypertrophy. The Journal of Biological Chemistry. 275: 35624-30. PMID 10958798 DOI: 10.1074/Jbc.M006124200  0.708
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