| Year |
Citation |
Score |
| 2022 |
Drilon A, Horan JC, Tangpeerachaikul A, Besse B, Ou SI, Gadgeel SM, Camidge DR, van der Wekken AJ, Nguyen-Phuong L, Acker A, Keddy C, Nicholson KS, Yoda S, Mente S, Sun Y, ... ... Shair MD, et al. NVL-520 is a selective, TRK-sparing, and brain-penetrant inhibitor of ROS1 fusions and secondary resistance mutations. Cancer Discovery. PMID 36511802 DOI: 10.1158/2159-8290.CD-22-0968 |
0.737 |
|
| 2022 |
Barrows RD, Jeffries DE, Vishe M, Tukachinsky H, Zheng SL, Li F, Ma Z, Li X, Jin S, Song H, Zhang R, Zhang S, Ni J, Luan H, Wen L, ... ... Shair MD, et al. Potent Uncompetitive Inhibitors of Nicotinamide -Methyltransferase (NNMT) as In Vivo Chemical Probes. Journal of Medicinal Chemistry. PMID 36288465 DOI: 10.1021/acs.jmedchem.2c01166 |
0.763 |
|
| 2020 |
Decultot L, Policarpo RL, Wright BA, Huang D, Shair MD. Asymmetric Total Synthesis of C9'--Sinefungin. Organic Letters. PMID 32628491 DOI: 10.1021/Acs.Orglett.0C01956 |
0.793 |
|
| 2019 |
Policarpo RL, Decultot L, May E, Kuzmic P, Carlson S, Huang D, Chu V, Wright BA, Dhakshinamoorthy S, Kannt A, Rani S, Dittakavi S, Panarese JD, Gaudet R, Shair MD. High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). Journal of Medicinal Chemistry. PMID 31589440 DOI: 10.1021/Acs.Jmedchem.9B01238 |
0.78 |
|
| 2019 |
Tucker JK, Shair MD. Catalytic Allylic Oxidation to Generate Vinylogous Acyl Sulfonates from Vinyl Sulfonates. Organic Letters. PMID 30883141 DOI: 10.1021/Acs.Orglett.9B00845 |
0.33 |
|
| 2017 |
Nitulescu II, Meyer SC, Wen QJ, Crispino JD, Lemieux ME, Levine RL, Pelish HE, Shair MD. Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. Ebiomedicine. 26: 112-125. PMID 29239838 DOI: 10.1016/J.Ebiom.2017.11.013 |
0.756 |
|
| 2017 |
Tahara T, Streit U, Pelish HE, Shair MD. STAT3 Inhibitory Activity of Structurally Simplified Withaferin A Analogues. Organic Letters. PMID 28350459 DOI: 10.1021/Acs.Orglett.7B00332 |
0.758 |
|
| 2016 |
Poss ZC, Ebmeier CC, Odell AT, Tangpeerachaikul A, Lee T, Pelish HE, Shair MD, Dowell RD, Old WM, Taatjes DJ. Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Reports. PMID 27050516 DOI: 10.1016/J.Celrep.2016.03.030 |
0.762 |
|
| 2015 |
Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, ... ... Shair MD, et al. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 526: 273-6. PMID 26416749 DOI: 10.1038/Nature14904 |
0.746 |
|
| 2015 |
Sparling BA, Tucker JK, Moebius DC, Shair MD. Total Synthesis of (-)-Nemorosone and (+)-Secohyperforin. Organic Letters. 17: 3398-401. PMID 26125288 DOI: 10.1021/Acs.Orglett.5B01121 |
0.818 |
|
| 2015 |
Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, ... ... Shair MD, et al. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Reports. 10: 600-15. PMID 25640182 DOI: 10.1016/J.Celrep.2014.12.054 |
0.327 |
|
| 2015 |
Liu Z, Nitulescu I, Pelish H, Shair M, Sola-Visner M. Mediator Kinase Inhibition Triggers a Phenotypic Switch from Neonatal to Adult-like Megakaryopoiesis Blood. 126: 1171-1171. DOI: 10.1182/Blood.V126.23.1171.1171 |
0.755 |
|
| 2014 |
Lee AS, Liau BB, Shair MD. A unified strategy for the synthesis of 7-membered-ring-containing Lycopodium alkaloids. Journal of the American Chemical Society. 136: 13442-52. PMID 25152067 DOI: 10.1021/Ja507740U |
0.73 |
|
| 2013 |
Lee AS, Shair MD. Synthesis of the C4-epi-lomaiviticin B core reveals subtle stereoelectronic effects. Organic Letters. 15: 2390-3. PMID 23659351 DOI: 10.1021/Ol400832R |
0.412 |
|
| 2013 |
Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T. The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. Molecular Biology of the Cell. 24: 1020-9. PMID 23389632 DOI: 10.1091/Mbc.E12-08-0575 |
0.755 |
|
| 2013 |
Sparling BA, Moebius DC, Shair MD. Enantioselective total synthesis of hyperforin. Journal of the American Chemical Society. 135: 644-7. PMID 23270309 DOI: 10.1021/Ja312150D |
0.817 |
|
| 2012 |
Liau BB, Milgram BC, Shair MD. Total syntheses of HMP-Y1, hibarimicinone, and HMP-P1. Journal of the American Chemical Society. 134: 16765-72. PMID 22970979 DOI: 10.1021/Ja307207Q |
0.78 |
|
| 2011 |
Milgram BC, Liau BB, Shair MD. Gram-scale synthesis of the A'B'-subunit of angelmicin B. Organic Letters. 13: 6436-9. PMID 22084899 DOI: 10.1021/Ol202728V |
0.786 |
|
| 2011 |
Burgett AW, Poulsen TB, Wangkanont K, Anderson DR, Kikuchi C, Shimada K, Okubo S, Fortner KC, Mimaki Y, Kuroda M, Murphy JP, Schwalb DJ, Petrella EC, Cornella-Taracido I, Schirle M, ... ... Shair MD, et al. Natural products reveal cancer cell dependence on oxysterol-binding proteins. Nature Chemical Biology. 7: 639-47. PMID 21822274 DOI: 10.1038/Nchembio.625 |
0.752 |
|
| 2010 |
Lee HG, Ahn JY, Lee AS, Shair MD. Enantioselective synthesis of the lomaiviticin aglycon full carbon skeleton reveals remarkable remote substituent effects during the dimerization event. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 13058-62. PMID 20976820 DOI: 10.1002/Chem.201002157 |
0.587 |
|
| 2010 |
Morris WJ, Shair MD. Synthesis of the N-(tert-butyloxycarbonyl)-O-triisopropylsilyl-D-pyrrolosamine Glycal of Lomaiviticin A & B via Epimerization of L-Threonine. Tetrahedron Letters. 51: 4310-4312. PMID 20802782 DOI: 10.1016/J.Tetlet.2010.06.028 |
0.356 |
|
| 2010 |
Liau BB, Shair MD. Total synthesis of (+)-fastigiatine. Journal of the American Chemical Society. 132: 9594-5. PMID 20568766 DOI: 10.1021/Ja104575H |
0.735 |
|
| 2010 |
Fortner KC, Kato D, Tanaka Y, Shair MD. Enantioselective synthesis of (+)-cephalostatin 1. Journal of the American Chemical Society. 132: 275-80. PMID 19968285 DOI: 10.1021/Ja906996C |
0.791 |
|
| 2010 |
Chen C, Layton ME, Sheehan SM, Shair MD. ChemInform Abstract: Synthesis of (+)-CP-263,114. Cheminform. 31: no-no. DOI: 10.1002/chin.200046230 |
0.665 |
|
| 2010 |
Sheehan SM, Lalic G, Chen JS, Shair MD. ChemInform Abstract: A Highly Efficient and Convergent Reaction for the Synthesis of Bridgehead Enone-Containing Polycyclic Ring Systems. Cheminform. 31: no-no. DOI: 10.1002/chin.200046120 |
0.69 |
|
| 2010 |
CHEN C, LAYTON ME, SHAIR MD. ChemInform Abstract: Stereospecific Synthesis of the CP-263,114 Core Structure. Cheminform. 30: no-no. DOI: 10.1002/chin.199909274 |
0.639 |
|
| 2009 |
Morris WJ, Shair MD. Stereoselective synthesis of 2-deoxy-beta-glycosides using anomeric O-alkylation/arylation. Organic Letters. 11: 9-12. PMID 19061365 DOI: 10.1021/Ol8022006 |
0.302 |
|
| 2008 |
Lee HM, Nieto-Oberhuber C, Shair MD. Enantioselective synthesis of (+)-cortistatin a, a potent and selective inhibitor of endothelial cell proliferation. Journal of the American Chemical Society. 130: 16864-6. PMID 19053422 DOI: 10.1021/Ja8071918 |
0.659 |
|
| 2008 |
Krygowski ES, Murphy-Benenato K, Shair MD. Enantioselective synthesis of the central ring system of lomaiviticin A in the form of an unusually stable cyclic hydrate. Angewandte Chemie (International Ed. in English). 47: 1680-4. PMID 18214870 DOI: 10.1002/Anie.200704830 |
0.788 |
|
| 2007 |
Phillips ST, Shair MD. Syntheses of the eastern halves of ritterazines B, F, G, and H, leading to reassignment of the 5,5-spiroketal stereochemistry of ritterazines B and F. Journal of the American Chemical Society. 129: 6589-98. PMID 17469826 DOI: 10.1021/Ja0705487 |
0.581 |
|
| 2007 |
Fortner KC, Shair MD. Stereoelectronic effects dictate mechanistic dichotomy between Cu(II)-catalyzed and enzyme-catalyzed reactions of malonic acid half thioesters. Journal of the American Chemical Society. 129: 1032-3. PMID 17263375 DOI: 10.1021/Ja0673682 |
0.787 |
|
| 2007 |
Shair M, Kirchhausen T, Hannoush R, Goess B. Reversible Small Molecule Induced Separation of Mammalian Golgi Cisternae The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A149-B |
0.755 |
|
| 2007 |
Shair M, Fortner K. Mechanistic Dichotomy: Cu(II)- and Enzyme-Catalyzed Aldol Reaction Synfacts. 2007: 0514-0514. DOI: 10.1055/s-2007-968454 |
0.773 |
|
| 2006 |
Pelish HE, Ciesla W, Tanaka N, Reddy K, Shair MD, Kirchhausen T, Lencer WI. The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochemical Pharmacology. 71: 1720-6. PMID 16677615 DOI: 10.1016/J.Bcp.2006.03.011 |
0.759 |
|
| 2006 |
Goess BC, Hannoush RN, Chan LK, Kirchhausen T, Shair MD. Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors. Journal of the American Chemical Society. 128: 5391-403. PMID 16620111 DOI: 10.1021/Ja056338G |
0.814 |
|
| 2006 |
Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nature Chemical Biology. 2: 39-46. PMID 16408091 DOI: 10.1038/Nchembio751 |
0.77 |
|
| 2006 |
Chan L, Kirchhausen T, Shair M, Goess B, Hannoush R. Diversity-Oriented Synthesis of a 10,102-Membered Library of Carpanones Synfacts. 2006: 0849-0849. DOI: 10.1055/s-2006-941985 |
0.526 |
|
| 2005 |
Magdziak D, Lalic G, Lee HM, Fortner KC, Aloise AD, Shair MD. Catalytic enantioselective thioester aldol reactions that are compatible with protic functional groups. Journal of the American Chemical Society. 127: 7284-5. PMID 15898756 DOI: 10.1021/Ja051759J |
0.759 |
|
| 2005 |
Xu K, Lalic G, Sheehan SM, Shair MD. Dynamic kinetic resolution during a cascade reaction on substrates with chiral all-carbon quaternary centers. Angewandte Chemie (International Ed. in English). 44: 2259-61. PMID 15751105 DOI: 10.1002/Anie.200462039 |
0.662 |
|
| 2004 |
Morales CA, Layton ME, Shair MD. Synthesis of (-)-longithorone A: using organic synthesis to probe a proposed biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 12036-41. PMID 15190180 DOI: 10.1073/Pnas.0401952101 |
0.795 |
|
| 2003 |
Lalic G, Aloise AD, Shair MD. An exceptionally mild catalytic thioester aldol reaction inspired by polyketide biosynthesis. Journal of the American Chemical Society. 125: 2852-3. PMID 12617633 DOI: 10.1021/Ja029452X |
0.786 |
|
| 2002 |
Layton ME, Morales CA, Shair MD. Biomimetic synthesis of (-)-longithorone A. Journal of the American Chemical Society. 124: 773-5. PMID 11817951 DOI: 10.1021/Ja016585U |
0.771 |
|
| 2001 |
Korbel GA, Lalic G, Shair MD. Reaction microarrays: a method for rapidly determining the enantiomeric excess of thousands of samples. Journal of the American Chemical Society. 123: 361-2. PMID 11456535 DOI: 10.1021/Ja0034747 |
0.768 |
|
| 2001 |
Pelish HE, Westwood NJ, Feng Y, Kirchhausen T, Shair MD. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product. Journal of the American Chemical Society. 123: 6740-1. PMID 11439080 DOI: 10.1021/Ja016093H |
0.814 |
|
| 2001 |
Tallarico JA, Depew KM, Pelish HE, Westwood NJ, Lindsley CW, Shair MD, Schreiber SL, Foley MA. An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synthesis for one-bead, one-stock solution chemical genetics. Journal of Combinatorial Chemistry. 3: 312-8. PMID 11350255 DOI: 10.1021/Cc000107I |
0.781 |
|
| 2001 |
Korber GA, Lalic G, Shair MD, Gilbertson SR. Reaction microarrays: A method for rapidly determining the enantiomeric excess of thousands of samples Chemtracts. 14: 200-203. |
0.634 |
|
| 2000 |
Sheehan SM, Lalic G, Chen JS, Shair MD. A Highly Efficient and Convergent Reaction for the Synthesis of Bridgehead Enone-Containing Polycyclic Ring Systems Financial support from the NIH (GM59403-01A1), Bristol-Myers Squibb, Merck Research Laboratories, Pharmacia & Upjohn, Smith-Kline Beecham, the Corning Fund, and the Research Corporation is gratefully acknowledged. G.L. acknowledges Eli Lilly for a graduate fellowship. Angewandte Chemie (International Ed. in English). 39: 2714-2715. PMID 10934402 DOI: 10.1002/1521-3773(20000804)39:15<2714::Aid-Anie2714>3.0.Co;2-1 |
0.663 |
|
| 2000 |
Lindsley CW, Chan LK, Goess BC, Joseph R, Shair MD. Solid-phase biomimetic synthesis of carpanone-like molecules Journal of the American Chemical Society. 122: 422-423. DOI: 10.1021/Ja993674M |
0.779 |
|
| 2000 |
Walters MA, Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays Chemtracts. 13: 268-275. DOI: 10.1021/Ja992144N |
0.738 |
|
| 2000 |
Aloise AD, Layton ME, Shair MD. Synthesis of cyclooctenones using intramolecular hydroacylation Journal of the American Chemical Society. 122: 12610-12611. DOI: 10.1021/Ja0055920 |
0.799 |
|
| 2000 |
Chen C, Layton ME, Sheehan SM, Shair MD. Synthesis of (+)-CP-263,114 [20] Journal of the American Chemical Society. 122: 7424-7425. DOI: 10.1021/Ja001958X |
0.786 |
|
| 2000 |
Walters MA, Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays Chemtracts. 13: 268-275. |
0.523 |
|
| 1998 |
Chen C, Layton ME, Shair MD. Stereospecific synthesis of the CP-263,114 core structure [13] Journal of the American Chemical Society. 120: 10784-10785. DOI: 10.1021/Ja982581M |
0.781 |
|
| 1998 |
Tan DS, Foley MA, Shair MD, Schreiber SL. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays [25] Journal of the American Chemical Society. 120: 8565-8566. DOI: 10.1021/Ja981746O |
0.668 |
|
| 1996 |
Danishefsky SJ, Shair MD. Observations in the Chemistry and Biology of Cyclic Enediyne Antibiotics: Total Syntheses of Calicheamicin γ1I and Dynemicin A Journal of Organic Chemistry. 61: 16-44. DOI: 10.1021/Jo951560X |
0.476 |
|
| 1996 |
Shair MD, Yoon TY, Mosny KK, Chou TC, Danishefsky SJ. The total synthesis of dynemicin A leading to development of a fully contained bioreductively activated enediyne prodrug Journal of the American Chemical Society. 118: 9509-9525. DOI: 10.1021/Ja960040W |
0.495 |
|
| 1995 |
Shair MD, Yoon T, Danishefsky SJ. Total Synthesis of(±)-Dynemicin A Angewandte Chemie International Edition in English. 34: 1721-1723. DOI: 10.1002/Anie.199517211 |
0.452 |
|
| 1995 |
Shair MD, Danishefsky SJ, Yoon T, Chou T. Enediyne Quinone Imines: Truncated, Biologically Active Dynemicin Congeners Angewandte Chemie International Edition in English. 33: 2477-2479. DOI: 10.1002/Anie.199424771 |
0.429 |
|
| 1995 |
Shair MD, Yoon T, Danishefsky SJ. Totalsynthese von (±)-Dynemicin A Angewandte Chemie. 107: 1883-1885. DOI: 10.1002/Ange.19951071616 |
0.371 |
|
| 1994 |
Shair MD, Yoon T, Danishefsky SJ. A remarkable cross coupling reaction to construct the enediyne linkage relevant to dynemicin A: Synthesis of the deprotected ABC system Journal of Organic Chemistry. 59: 3755-3757. DOI: 10.1021/Jo00093A003 |
0.371 |
|
| 1994 |
Yoon T, Shair MD, Danishefsky SJ, Shulte GK. Experiments directed toward a total synthesis of dynemicin A: A solution to the stereochemical problem Journal of Organic Chemistry. 59: 3752-3754. DOI: 10.1021/Jo00093A002 |
0.387 |
|
| 1994 |
Yoon T, Shair MD, Danishefsky SJ. An advanced dynemicin A model: Stabilization of the 3,8-epoxide by anthraquinone functionality in the absence of the bridging enediyne Tetrahedron Letters. 35: 6259-6262. DOI: 10.1016/S0040-4039(00)73406-X |
0.313 |
|
| 1994 |
Shair MD, Yoon T, Chou T, Danishefsky SJ. Endiin-Chinonimine: verkleinerte, biologisch aktive Dynemicinanaloga Angewandte Chemie. 106: 2578-2580. DOI: 10.1002/Ange.19941062337 |
0.44 |
|
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