207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ray A, Wen J, Yammine L, Culver J, Parida IS, Garren J, Xue L, Hales K, Xiang Q, Birnbaum MJ, Zhang BB, Monetti M, McGraw TE. Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells. Journal of Cell Science. 136. PMID 38126809 DOI: 10.1242/jcs.261454  0.344
2023 Flaherty SE, Bezy O, Zheng W, Yan D, Li X, Jagarlapudi S, Albuquerque B, Esquejo RM, Peloquin M, Semache M, Mancini A, Kang L, Drujan D, Breitkopf SB, Griffin JD, ... ... Birnbaum MJ, et al. Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity. Nature Communications. 14: 3953. PMID 37402735 DOI: 10.1038/s41467-023-39597-w  0.395
2023 Ray A, Wen J, Yammine L, Culver J, Garren J, Xue L, Hales K, Xiang Q, Birnbaum MJ, Zhang BB, Monetti M, McGraw TE. GLUT4 dynamic subcellular localization is controlled by AMP kinase activation as revealed by proximal proteome mapping in human muscle cells. Biorxiv : the Preprint Server For Biology. PMID 37333333 DOI: 10.1101/2023.06.06.543897  0.372
2021 James DE, Stöckli J, Birnbaum MJ. The aetiology and molecular landscape of insulin resistance. Nature Reviews. Molecular Cell Biology. PMID 34285405 DOI: 10.1038/s41580-021-00390-6  0.393
2019 Good AL, Cannon CE, Haemmerle MW, Yang J, Stanescu DE, Doliba NM, Birnbaum MJ, Stoffers DA. JUND regulates pancreatic β cell survival during metabolic stress. Molecular Metabolism. PMID 31023625 DOI: 10.1016/J.Molmet.2019.04.007  0.304
2018 Esquejo RM, Salatto CT, Delmore J, Albuquerque B, Reyes A, Shi Y, Moccia R, Cokorinos E, Peloquin M, Monetti M, Barricklow J, Bollinger E, Smith BK, Day EA, Nguyen C, ... ... Birnbaum MJ, et al. Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models. Ebiomedicine. PMID 29673898 DOI: 10.1016/J.Ebiom.2018.04.009  0.328
2018 Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nature Medicine. PMID 29578539 DOI: 10.1038/Nm.4514  0.486
2018 Roth SW, Bitterman MD, Birnbaum MJ, Bland ML. Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)PProduction and Akt Activation. Cell Reports. 22: 2550-2556. PMID 29514084 DOI: 10.1016/J.Celrep.2018.02.033  0.464
2018 Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metabolism. 27: 351-361.e3. PMID 29414685 DOI: 10.1016/J.Cmet.2017.12.016  0.353
2018 Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, et al. Hepatic Gi signaling regulates whole-body glucose homeostasis. The Journal of Clinical Investigation. PMID 29337301 DOI: 10.1172/Jci94505  0.451
2018 TODA G, KAMEI N, SOEDA K, MASUDA Y, IZUMIDA Y, KOBAYASHI N, SASAKO T, TOBE K, BIRNBAUM MJ, KADOWAKI T, UEKI K. Macrophages React to Postprandial Signals and Regulate the Response to Feeding through Akt-mTOR–Dependent Production of IL-10 Diabetes. 67: 359-OR. DOI: 10.2337/Db18-359-Or  0.384
2017 Quinn WJ, Wan M, Shewale SV, Gelfer R, Rader DJ, Birnbaum MJ, Titchenell PM. mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. The Journal of Clinical Investigation. PMID 29035283 DOI: 10.1172/Jci96036  0.714
2017 Titchenell PM, Lazar MA, Birnbaum MJ. Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends in Endocrinology and Metabolism: Tem. PMID 28416361 DOI: 10.1016/J.Tem.2017.03.003  0.768
2017 Salatto CT, Miller RA, Cameron KO, Cokorinos E, Reyes A, Ward J, Calabrese M, Kurumbail R, Rajamohan F, Kalgutkar AS, Tess DA, Shavnya A, Genung NE, Edmonds DJ, Jatkar A, ... ... Birnbaum MJ, et al. Selective Activation of AMPK b1-containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 28289077 DOI: 10.1124/Jpet.116.237925  0.343
2016 Jang H, Lee GY, Selby CP, Lee G, Jeon YG, Lee JH, Cheng KK, Titchenell P, Birnbaum MJ, Xu A, Sancar A, Kim JB. SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nature Communications. 7: 12180. PMID 27412556 DOI: 10.1038/Ncomms12180  0.764
2016 Shearin AL, Monks BR, Seale P, Birnbaum MJ. Lack of AKT in adipocytes causes severe lipodystrophy. Molecular Metabolism. 5: 472-9. PMID 27408773 DOI: 10.1016/J.Molmet.2016.05.006  0.5
2016 Titchenell PM, Quinn WJ, Lu M, Chu Q, Lu W, Li C, Chen H, Monks BR, Chen J, Rabinowitz JD, Birnbaum MJ. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metabolism. PMID 27238637 DOI: 10.1016/J.Cmet.2016.04.022  0.772
2016 Zhang Z, Amorosa LF, Coyle SM, Macor MA, Birnbaum MJ, Lee LY, Haimovich B. Insulin-dependent regulation of mTORC2-Akt-FoxO suppresses TLR4 signaling in human leukocytes: Relevance to type 2 diabetes. Diabetes. PMID 27207509 DOI: 10.2337/Db16-0027  0.438
2016 Miller RA, Birnbaum MJ. Glucagon: acute actions on hepatic metabolism. Diabetologia. PMID 27115415 DOI: 10.1007/S00125-016-3955-Y  0.387
2016 Wang Q, Yu WN, Chen X, Peng XD, Jeon SM, Birnbaum MJ, Guzman G, Hay N. Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. Cancer Cell. PMID 26996309 DOI: 10.1016/J.Ccell.2016.02.008  0.327
2015 Chen Q, Lu M, Monks BR, Birnbaum MJ. Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1. The Journal of Biological Chemistry. PMID 26668316 DOI: 10.1074/Jbc.M115.677351  0.532
2015 Pauta M, Rotllan N, Fernández-Hernando A, Langhi C, Ribera J, Lu M, Boix L, Bruix J, Jimenez W, Suárez Y, Ford DA, Baldán A, Birnbaum MJ, Morales-Ruiz M, Fernández-Hernando C. Akt-mediated FoxO1 inhibition is required for liver regeneration. Hepatology (Baltimore, Md.). PMID 26473496 DOI: 10.1002/Hep.28286  0.395
2015 Feng D, Youn DY, Zhao X, Gao Y, Quinn WJ, Xiaoli AM, Sun Y, Birnbaum MJ, Pessin JE, Yang F. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). Plos One. 10: e0126240. PMID 26042770 DOI: 10.1371/Journal.Pone.0126240  0.452
2015 DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Molecular and Cellular Biology. 35: 2752-60. PMID 26031333 DOI: 10.1128/Mcb.00422-15  0.529
2015 Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, et al. Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Science Signaling. 8: ra44. PMID 25969542 DOI: 10.1126/Scisignal.2005482  0.388
2015 Titchenell PM, Chu Q, Monks BR, Birnbaum MJ. Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nature Communications. 6: 7078. PMID 25963408 DOI: 10.1038/Ncomms8078  0.776
2015 Koren S, DiPilato LM, Emmett MJ, Shearin AL, Chu Q, Monks B, Birnbaum MJ. The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo. Diabetologia. 58: 1063-70. PMID 25740694 DOI: 10.1007/S00125-015-3532-9  0.52
2015 Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, ... Birnbaum MJ, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 160: 745-58. PMID 25662011 DOI: 10.1016/J.Cell.2015.01.012  0.76
2014 Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA. The Polycomb protein, Bmi1, regulates insulin sensitivity. Molecular Metabolism. 3: 794-802. PMID 25379404 DOI: 10.1016/J.Molmet.2014.08.002  0.739
2014 Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. American Journal of Physiology. Renal Physiology. 307: F1380-9. PMID 25253241 DOI: 10.1152/Ajprenal.00454.2014  0.397
2014 Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways Nature Immunology. 15: 996-996. PMID 25232822 DOI: 10.1038/Ni0910-996  0.354
2014 Baur JA, Birnbaum MJ. Control of gluconeogenesis by metformin: does redox trump energy charge? Cell Metabolism. 20: 197-9. PMID 25100057 DOI: 10.1016/J.Cmet.2014.07.013  0.323
2014 Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, ... Birnbaum MJ, et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications. 5: 4535. PMID 25088745 DOI: 10.1038/Ncomms5535  0.77
2013 Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L. Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways. The Journal of Biological Chemistry. 288: 33966-77. PMID 24126911 DOI: 10.1074/Jbc.M113.492702  0.414
2013 Wan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC, Birnbaum MJ. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell Metabolism. 18: 99-105. PMID 23823480 DOI: 10.1016/J.Cmet.2013.06.001  0.549
2013 Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature Immunology. 14: 611-8. PMID 23644504 DOI: 10.1038/Ni.2607  0.369
2013 Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, ... ... Birnbaum MJ, et al. Construction of human activity-based phosphorylation networks. Molecular Systems Biology. 9: 655. PMID 23549483 DOI: 10.1038/Msb.2013.12  0.354
2013 Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 494: 256-60. PMID 23292513 DOI: 10.1038/Nature11808  0.518
2012 Quinn WJ, Birnbaum MJ. Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c. Proceedings of the National Academy of Sciences of the United States of America. 109: 15974-5. PMID 23012450 DOI: 10.1073/Pnas.1214113109  0.489
2012 Sassu ED, McDermott JE, Keys BJ, Esmaeili M, Keene AC, Birnbaum MJ, DiAngelo JR. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Biochemical and Biophysical Research Communications. 426: 43-8. PMID 22910416 DOI: 10.1016/J.Bbrc.2012.08.028  0.345
2012 Treins C, Alliouachene S, Hassouna R, Xie Y, Birnbaum MJ, Pende M. The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet. Molecular and Cellular Biology. 32: 4001-11. PMID 22851690 DOI: 10.1128/Mcb.00514-12  0.518
2012 Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine. 18: 934-42. PMID 22561686 DOI: 10.1038/Nm.2744  0.468
2012 Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature Medicine. 18: 388-95. PMID 22344295 DOI: 10.1038/Nm.2686  0.526
2012 Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Fajas L, Foretz M, Verdeguer F, Pontoglio M, Ferré P, Scoazec JY, Birnbaum MJ, Ricci JE, et al. PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nature Communications. 3: 672. PMID 22334075 DOI: 10.1038/Ncomms1667  0.408
2012 Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Nuñez G, Samavati L. TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages. Journal of Immunology (Baltimore, Md. : 1950). 188: 2847-57. PMID 22312125 DOI: 10.4049/Jimmunol.1102157  0.341
2012 Wan M, Easton RM, Gleason CE, Monks BR, Ueki K, Kahn CR, Birnbaum MJ. Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Molecular and Cellular Biology. 32: 96-106. PMID 22037765 DOI: 10.1128/Mcb.05806-11  0.389
2012 Chatterjee S, Browning EA, Hong N, DeBolt K, Sorokina EM, Liu W, Birnbaum MJ, Fisher AB. Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. American Journal of Physiology. Heart and Circulatory Physiology. 302: H105-14. PMID 22003059 DOI: 10.1152/Ajpheart.00298.2011  0.329
2012 Kim JS, Sklarz T, Waickman A, Li MO, Rathmell J, Birnbaum M, Powell J, Jordan MS, Koretzky GA. Akt and mTOR Pathways Differentially Regulate the Development of Natural and Inducible IL-17-Producing CD4+ T Cells Blood. 120: 838-838. DOI: 10.1182/Blood.V120.21.838.838  0.353
2011 Wan M, Birnbaum MJ. Of mice and men: not ExAKTly the same? Cell Metabolism. 14: 722-3. PMID 22152300 DOI: 10.1016/J.Cmet.2011.11.009  0.406
2011 Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism. 14: 516-27. PMID 21982711 DOI: 10.1016/J.Cmet.2011.09.001  0.501
2011 Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Molecular Endocrinology (Baltimore, Md.). 25: 2106-18. PMID 21980074 DOI: 10.1210/Me.2010-0329  0.536
2011 Bland ML, Birnbaum MJ. Cell biology. ADaPting to energetic stress. Science (New York, N.Y.). 332: 1387-8. PMID 21680830 DOI: 10.1126/Science.1208444  0.317
2011 Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of Clinical Investigation. 121: 2518-28. PMID 21606593 DOI: 10.1172/Jci45942  0.491
2011 Leavens KF, Birnbaum MJ. Insulin signaling to hepatic lipid metabolism in health and disease. Critical Reviews in Biochemistry and Molecular Biology. 46: 200-15. PMID 21599535 DOI: 10.3109/10409238.2011.562481  0.498
2011 Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, ... Birnbaum MJ, et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nature Medicine. 17: 55-63. PMID 21186369 DOI: 10.1038/Nm.2277  0.419
2011 Tokuda S, Mahaffey CL, Monks B, Faulkner CR, Birnbaum MJ, Danzer SC, Frankel WN. A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Human Molecular Genetics. 20: 988-99. PMID 21159799 DOI: 10.1093/Hmg/Ddq544  0.35
2010 Liu J, Wang Y, Birnbaum MJ, Stoffers DA. Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Proceedings of the National Academy of Sciences of the United States of America. 107: 20494-9. PMID 21059917 DOI: 10.1073/Pnas.1007001107  0.386
2010 Goncalves MD, Pistilli EE, Balduzzi A, Birnbaum MJ, Lachey J, Khurana TS, Ahima RS. Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition. Plos One. 5: e12707. PMID 20856813 DOI: 10.1371/Journal.Pone.0012707  0.318
2010 Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, Alvarez JV, Birnbaum MJ, Chodosh LA. Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Research : Bcr. 12: R72. PMID 20849614 DOI: 10.1186/Bcr2640  0.408
2010 Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 139: 2170-82. PMID 20837017 DOI: 10.1053/J.Gastro.2010.09.002  0.319
2010 Choi SM, Tucker DF, Gross DN, Easton RM, DiPilato LM, Dean AS, Monks BR, Birnbaum MJ. Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Molecular and Cellular Biology. 30: 5009-20. PMID 20733001 DOI: 10.1128/Mcb.00797-10  0.542
2010 Guha M, Fang JK, Monks R, Birnbaum MJ, Avadhani NG. Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2. Molecular Biology of the Cell. 21: 3578-89. PMID 20719961 DOI: 10.1091/Mbc.E10-03-0192  0.337
2010 Hamamdzic D, Fenning RS, Patel D, Mohler ER, Orlova KA, Wright AC, Llano R, Keane MG, Shannon RP, Birnbaum MJ, Wilensky RL. Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease. American Journal of Physiology. Heart and Circulatory Physiology. 299: H699-706. PMID 20601459 DOI: 10.1152/Ajpheart.00071.2010  0.309
2010 Miller RA, Birnbaum MJ. An energetic tale of AMPK-independent effects of metformin. The Journal of Clinical Investigation. 120: 2267-70. PMID 20577046 DOI: 10.1172/Jci43661  0.478
2010 Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F. Regulation of gastric acid secretion by PKB/Akt2. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 25: 695-704. PMID 20511715 DOI: 10.1159/000315089  0.357
2010 Bland ML, Lee RJ, Magallanes JM, Foskett JK, Birnbaum MJ. AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut. Developmental Biology. 344: 293-303. PMID 20478298 DOI: 10.1016/J.Ydbio.2010.05.010  0.347
2010 Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood. 115: 4030-8. PMID 20354168 DOI: 10.1182/Blood-2009-09-241000  0.355
2010 He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. The American Journal of Pathology. 176: 2302-8. PMID 20348245 DOI: 10.2353/Ajpath.2010.090931  0.461
2010 Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F. Regulation of renal tubular glucose reabsorption by Akt2/PKBβ. American Journal of Physiology. Renal Physiology. 298: F1113-7. PMID 20164156 DOI: 10.1152/Ajprenal.00592.2009  0.456
2010 Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 115: 4043-50. PMID 20042722 DOI: 10.1182/Blood-2009-09-241638  0.328
2010 Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ. Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. Molecular Endocrinology (Baltimore, Md.). 24: 178-92. PMID 19897600 DOI: 10.1210/Me.2009-0167  0.474
2009 Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ. Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth. Endocrine Reviews. 30: 930. PMID 28199555 DOI: 10.1210/Edrv.30.7.9990  0.383
2009 Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metabolism. 10: 405-18. PMID 19883618 DOI: 10.1016/J.Cmet.2009.10.004  0.517
2009 DiAngelo JR, Bland ML, Bambina S, Cherry S, Birnbaum MJ. The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 20853-8. PMID 19861550 DOI: 10.1073/Pnas.0906749106  0.359
2009 DiAngelo JR, Birnbaum MJ. Regulation of fat cell mass by insulin in Drosophila melanogaster. Molecular and Cellular Biology. 29: 6341-52. PMID 19822665 DOI: 10.1128/Mcb.00675-09  0.531
2009 Gross DN, Wan M, Birnbaum MJ. The role of FOXO in the regulation of metabolism. Current Diabetes Reports. 9: 208-14. PMID 19490822 DOI: 10.1007/S11892-009-0034-5  0.531
2009 Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D. Akt2 and SGK3 are both determinants of postnatal hair follicle development. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3193-202. PMID 19433625 DOI: 10.1096/Fj.08-123729  0.368
2009 Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circulation Research. 104: 1085-94. PMID 19342603 DOI: 10.1161/Circresaha.108.189316  0.489
2009 Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM, Lee SY, Yun J, Kim CD, Birnbaum MJ, Bae SS. Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. Febs Letters. 583: 685-90. PMID 19166849 DOI: 10.1016/J.Febslet.2009.01.005  0.35
2009 Steinberg GR, Watt MJ, Ernst M, Birnbaum MJ, Kemp BE, Jørgensen SB. Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity. Diabetes. 58: 829-39. PMID 19136654 DOI: 10.2337/Db08-0659  0.491
2009 Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA. PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle (FASEB Journal (2005) DOI: 10.1096/fj.05-3993fje) Faseb Journal. 23: 2790. DOI: 10.1096/Fj.05-3993Fjeret  0.443
2008 Plastaras JP, Dorsey JF, Carroll K, Kim SH, Birnbaum MJ, El-Deiry WS. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer Biology & Therapy. 7: 2047-53. PMID 19106634 DOI: 10.4161/Cbt.7.12.7570  0.492
2008 Alliouachene S, Tuttle RL, Boumard S, Lapointe T, Berissi S, Germain S, Jaubert F, Tosh D, Birnbaum MJ, Pende M. Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation. The Journal of Clinical Investigation. 118: 3629-38. PMID 18846252 DOI: 10.1172/Jci35237  0.494
2008 Kim EK, Yun SJ, Do KH, Kim MS, Cho M, Suh DS, Kim CD, Kim JH, Birnbaum MJ, Bae SS. Lysophosphatidic acid induces cell migration through the selective activation of Akt1. Experimental & Molecular Medicine. 40: 445-52. PMID 18779657 DOI: 10.3858/Emm.2008.40.4.445  0.367
2008 Kim EK, Tucker DF, Yun SJ, Do KH, Kim MS, Kim JH, Kim CD, Birnbaum MJ, Bae SS. Linker region of Akt1/protein kinase Balpha mediates platelet-derived growth factor-induced translocation and cell migration. Cellular Signalling. 20: 2030-7. PMID 18700164 DOI: 10.1016/J.Cellsig.2008.07.012  0.408
2008 Yun SJ, Kim EK, Tucker DF, Kim CD, Birnbaum MJ, Bae SS. Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha. Biochemical and Biophysical Research Communications. 371: 138-43. PMID 18423396 DOI: 10.1016/J.Bbrc.2008.04.029  0.43
2008 Gross DN, van den Heuvel AP, Birnbaum MJ. The role of FoxO in the regulation of metabolism. Oncogene. 27: 2320-36. PMID 18391974 DOI: 10.1038/Onc.2008.25  0.504
2008 Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3622-7. PMID 18292230 DOI: 10.1073/Pnas.0709180105  0.346
2008 Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. The Journal of Clinical Investigation. 118: 812-9. PMID 18188447 DOI: 10.1172/Jci34239  0.304
2007 Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, Strynadka K, Chohnan S, Smith WW, Tamashiro KL, Ladenheim EE, Ronnett GV, Tu Y, Birnbaum MJ, Lopaschuk GD, et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proceedings of the National Academy of Sciences of the United States of America. 104: 17358-63. PMID 17956983 DOI: 10.1073/Pnas.0708385104  0.344
2007 O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, ... Birnbaum MJ, et al. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metabolism. 6: 294-306. PMID 17908558 DOI: 10.1016/J.Cmet.2007.09.001  0.359
2007 Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 104: 12105-10. PMID 17609365 DOI: 10.1073/Pnas.0705285104  0.387
2007 Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature. 447: 1012-6. PMID 17554339 DOI: 10.1038/Nature05861  0.503
2007 Gleason CE, Gross DN, Birnbaum MJ. When the usual insulin is just not enough. Proceedings of the National Academy of Sciences of the United States of America. 104: 8681-2. PMID 17517662 DOI: 10.1073/Pnas.0702844104  0.485
2007 O'Shaughnessy RF, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C. AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation. The Journal of Biological Chemistry. 282: 17297-305. PMID 17439945 DOI: 10.1074/Jbc.M610386200  0.353
2007 Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metabolism. 5: 167-79. PMID 17339025 DOI: 10.1016/J.Cmet.2007.01.002  0.455
2007 Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. The Journal of Biological Chemistry. 282: 10341-51. PMID 17287212 DOI: 10.1074/Jbc.M610631200  0.516
2007 Birnbaum MJ. Regulation of Glucose and Lipid Metabolism by Akt/PKB The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A44-E  0.414
2006 Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metabolism. 4: 475-90. PMID 17141631 DOI: 10.1016/J.Cmet.2006.10.011  0.413
2006 Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J. Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. The Journal of Biological Chemistry. 281: 36443-53. PMID 17012749 DOI: 10.1074/Jbc.M600788200  0.415
2006 Liu X, Shi Y, Birnbaum MJ, Ye K, De Jong R, Oltersdorf T, Giranda VL, Luo Y. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. The Journal of Biological Chemistry. 281: 31380-8. PMID 16923802 DOI: 10.1074/Jbc.M606603200  0.367
2006 Evans GJ, Barclay JW, Prescott GR, Jo SR, Burgoyne RD, Birnbaum MJ, Morgan A. Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. The Journal of Biological Chemistry. 281: 1564-72. PMID 16243840 DOI: 10.1074/Jbc.M503628200  0.462
2006 Chen X, Wang Y, Williamson EK, Stalker TJ, Brass LF, Birnbaum MJ, Harwig JH, Abrams CS. Loss of PIP5KIβ Causes a Defect in Lamellipodia Formation and Shear Resistant Adhesion. Blood. 108: 141-141. DOI: 10.1182/Blood.V108.11.141.141  0.327
2005 Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA. PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2072-4. PMID 16203862 DOI: 10.1096/Fj.05-3993Fje  0.512
2005 Kim IA, Bae SS, Fernandes A, Wu J, Muschel RJ, McKenna WG, Birnbaum MJ, Bernhard EJ. Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Research. 65: 7902-10. PMID 16140961 DOI: 10.1158/0008-5472.Can-05-0513  0.361
2005 Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. The Journal of Clinical Investigation. 115: 2119-27. PMID 16075056 DOI: 10.1172/Jci24726  0.393
2005 Birnbaum MJ. Activating AMP-activated protein kinase without AMP. Molecular Cell. 19: 289-90. PMID 16061173 DOI: 10.1016/J.Molcel.2005.07.012  0.357
2005 Birnbaum MJ. SHIPing news: a new way to keep your weight down. Cell Metabolism. 1: 90-2. PMID 16054050 DOI: 10.1016/J.Cmet.2005.01.007  0.348
2005 Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular Cell. 18: 283-93. PMID 15866171 DOI: 10.1016/J.Molcel.2005.03.027  0.435
2005 Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Molecular and Cellular Biology. 25: 1869-78. PMID 15713641 DOI: 10.1128/Mcb.25.5.1869-1878.2005  0.444
2005 Hammerman PS, Fox CJ, Birnbaum MJ, Thompson CB. Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood. 105: 4477-83. PMID 15705789 DOI: 10.1182/Blood-2004-09-3706  0.375
2005 Patel NA, Kaneko S, Apostolatos HS, Bae SS, Watson JE, Davidowitz K, Chappell DS, Birnbaum MJ, Cheng JQ, Cooper DR. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. The Journal of Biological Chemistry. 280: 14302-9. PMID 15684423 DOI: 10.1074/Jbc.M411485200  0.414
2005 Steppan CM, Wang J, Whiteman EL, Birnbaum MJ, Lazar MA. Activation of SOCS-3 by resistin. Molecular and Cellular Biology. 25: 1569-75. PMID 15684405 DOI: 10.1128/Mcb.25.4.1569-1575.2005  0.544
2004 Birnbaum MJ. On the InterAktion between hexokinase and the mitochondrion. Developmental Cell. 7: 781-2. PMID 15572122 DOI: 10.1016/J.Devcel.2004.11.016  0.338
2004 Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB. The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science (New York, N.Y.). 306: 695-8. PMID 15499020 DOI: 10.1126/Science.1100537  0.31
2004 Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). The Journal of Biological Chemistry. 279: 45304-7. PMID 15364919 DOI: 10.1074/Jbc.C400186200  0.516
2004 Russell RR, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. The Journal of Clinical Investigation. 114: 495-503. PMID 15314686 DOI: 10.1172/Jci19297  0.404
2004 Holmes BF, Lang DB, Birnbaum MJ, Mu J, Dohm GL. AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 287: E739-43. PMID 15165992 DOI: 10.1152/Ajpendo.00080.2004  0.321
2004 Minokoshi Y, Alquier T, Furukawa H, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature. 428: 569-574. PMID 15058305 DOI: 10.1038/Nature02440  0.417
2004 Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF. Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. The Journal of Clinical Investigation. 113: 441-50. PMID 14755341 DOI: 10.1172/Jci20267  0.348
2004 Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M. Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Gastroenterology. 126: 122-35. PMID 14699494 DOI: 10.1053/J.Gastro.2003.10.061  0.357
2004 Roovers K, Birnbaum MJ. 19 Regulation of Cell Growth in the Endocrine Pancreas Cold Spring Harbor Monograph Archive. 42: 605-623. DOI: 10.1101/087969672.42.605  0.365
2003 Lawrence JTR, Birnbaum MJ. ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate Proceedings of the National Academy of Sciences of the United States of America. 100: 13320-13325. PMID 14585928 DOI: 10.1073/Pnas.2232129100  0.494
2003 Bae SS, Cho H, Mu J, Birnbaum MJ. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B The Journal of Biological Chemistry. 278: 49530-49536. PMID 14522993 DOI: 10.1074/Jbc.M306782200  0.57
2003 Yin W, Mu J, Birnbaum MJ. Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis in 3T3-L1 Adipocytes Journal of Biological Chemistry. 278: 43074-43080. PMID 12941946 DOI: 10.1074/Jbc.M308484200  0.478
2003 Whiteman EL, Chen JJ, Birnbaum MJ. Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates Endocrinology. 144: 3811-3820. PMID 12933652 DOI: 10.1210/En.2003-0480  0.533
2003 Birnbaum MJ. Lipolysis: More than just a lipase Journal of Cell Biology. 161: 1011-1012. PMID 12810703 DOI: 10.1083/Jcb.200306008  0.339
2003 Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P, Thorens B. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization Journal of Clinical Investigation. 111: 1555-1562. PMID 12750405 DOI: 10.1172/Jci16888  0.489
2003 Whiteman EL, Birnbaum MJ. Assaying tyrosine phosphorylation of insulin receptor and insulin receptor substrates Methods in Molecular Medicine. 83: 119-126. PMID 12619723 DOI: 10.1385/1-59259-377-1:119  0.447
2003 Mu J, Barton ER, Birnbaum MJ. Selective suppression of AMP-activated protein kinase in skeletal muscle: Update on 'lazy mice' Biochemical Society Transactions. 31: 236-241. PMID 12546693 DOI: 10.1042/Bst0310236  0.341
2003 Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner Journal of Biological Chemistry. 278: 10189-10194. PMID 12524439 DOI: 10.1074/Jbc.M210837200  0.441
2003 Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, ... ... Birnbaum MJ, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. The Journal of Clinical Investigation. 111: 91-8. PMID 12511592 DOI: 10.1172/Jci16567  0.535
2002 Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15983-7. PMID 12444247 DOI: 10.1073/Pnas.252625599  0.345
2002 Whiteman EL, Cho H, Birnbaum MJ. Role of Akt/protein kinase B in metabolism Trends in Endocrinology and Metabolism. 13: 444-451. PMID 12431841 DOI: 10.1016/S1043-2760(02)00662-8  0.503
2002 Stolovich M, Tang H, Hornstein E, Levy G, Cohen R, Bae SS, Birnbaum MJ, Meyuhas O. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Molecular and Cellular Biology. 22: 8101-13. PMID 12417714 DOI: 10.1128/Mcb.22.23.8101-8113.2002  0.385
2002 Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum MJ, Chao MV. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 35: 697-709. PMID 12194869 DOI: 10.1016/S0896-6273(02)00821-8  0.367
2002 Kim HS, Skurk C, Thomas SR, Bialik A, Suhara T, Kureishi Y, Birnbaum M, Keaney JF, Walsh K. Regulation of angiogenesis by glycogen synthase kinase-3beta. The Journal of Biological Chemistry. 277: 41888-96. PMID 12167628 DOI: 10.1074/Jbc.M206657200  0.384
2002 Birnbaum MJ. RhoGAP: The next big thing for small mice? Developmental Cell. 2: 521-523. PMID 12015960 DOI: 10.1016/S1534-5807(02)00183-1  0.382
2001 Viollet B, Andreelli F, Jorgensen SB, Perrin C, Flamez D, Mu J, Wojtaszewski JF, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont S. Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochemical Society Transactions. 31: 216-219. PMID 12546688 DOI: 10.1042/Bst0310216  0.494
2001 Nadler ST, Stoehr JP, Rabaglia ME, Schueler KL, Birnbaum MJ, Attie AD. Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice American Journal of Physiology - Endocrinology and Metabolism. 281: E1249-E1254. PMID 11701440 DOI: 10.1152/Ajpendo.2001.281.6.E1249  0.512
2001 Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, Furth EE, Polonsky KS, Naji A, Birnbaum MJ. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nature Medicine. 7: 1133-7. PMID 11590437 DOI: 10.1038/Nm1001-1133  0.486
2001 Choi SL, Kim SJ, Lee KT, Kim J, Mu J, Birnbaum MJ, Soo Kim S, Ha J. The regulation of AMP-activated protein kinase by H2O2 Biochemical and Biophysical Research Communications. 287: 92-97. PMID 11549258 DOI: 10.1006/Bbrc.2001.5544  0.368
2001 Birnbaum MJ. Turning down insulin signaling Journal of Clinical Investigation. 108: 655-659. PMID 11544268 DOI: 10.1172/Jci13714  0.398
2001 Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice Journal of Biological Chemistry. 276: 38349-38352. PMID 11533044 DOI: 10.1074/Jbc.C100462200  0.5
2001 Todd J, Lawrence R, Birnbaum MJ. ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes Molecular and Cellular Biology. 21: 5276-5285. PMID 11438681 DOI: 10.1128/Mcb.21.15.5276-5285.2001  0.503
2001 Mu J, Brozinick JT, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle Molecular Cell. 7: 1085-1094. PMID 11389854 DOI: 10.1016/S1097-2765(01)00251-9  0.414
2001 Miron M, Verdú J, Lachance PE, Birnbaum MJ, Lasko PF, Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nature Cell Biology. 3: 596-601. PMID 11389445 DOI: 10.1038/35078571  0.353
2001 Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) Science. 292: 1728-1731. PMID 11387480 DOI: 10.1126/Science.292.5522.1728  0.556
2001 Li Y, Tennekoon GI, Birnbaum M, Marchionni MA, Rutkowski JL. Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival. Molecular and Cellular Neuroscience. 17: 761-767. PMID 11312610 DOI: 10.1006/Mcne.2000.0967  0.408
2001 Birnbaum MJ. Diabetes. Dialogue between muscle and fat Nature. 409: 672-673. PMID 11217842 DOI: 10.1038/35055643  0.379
2001 Birnbaum M. Role of PI3Ks and protein kinases in GLUT4 trafficking Biochemical Society Transactions. 29: A60-A60. DOI: 10.1042/Bst029A060  0.383
2000 Summers SA, Whiteman EL, Birnbaum MJ. Insulin signaling in the adipocyte International Journal of Obesity. 24: S67-S70. PMID 11126246 DOI: 10.1038/Sj.Ijo.0801509  0.546
2000 Li M, Wang X, Meintzer MK, Laessig T, Birnbaum MJ, Heidenreich KA. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β Molecular and Cellular Biology. 20: 9356-9363. PMID 11094086 DOI: 10.1128/Mcb.20.24.9356-9363.2000  0.343
2000 Okano JI, Gaslightwala I, Birnbaum MJ, Rustgi AK, Nakagawa H. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation Journal of Biological Chemistry. 275: 30934-30942. PMID 10908564 DOI: 10.1074/Jbc.M004112200  0.404
2000 Garza LA, Birnbaum MJ. Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes Journal of Biological Chemistry. 275: 2560-2567. PMID 10644714 DOI: 10.1074/Jbc.275.4.2560  0.456
2000 Okano J, Gaslightwala I, Nakagawa H, Birnbaum MJ, Rustgi AK. Epidermal growth factor induced phosphoinositide 3-OH kinase pathway dependent activation of protein kinase B/Akt in human esophageal cancer cell lines Gastroenterology. 118: A90. DOI: 10.1016/S0016-5085(00)82438-5  0.364
1999 Summers SA, Yin VP, Whiteman EL, Garza LA, Cho H, Tuttle RL, Birnbaum MJ. Signaling pathways mediating insulin-stimulated glucose transport. Annals of the New York Academy of Sciences. 892: 169-86. PMID 10842662 DOI: 10.1111/J.1749-6632.1999.Tb07795.X  0.566
1999 Verdu J, Buratovich MA, Wilder EL, Birnbaum MJ. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nature Cell Biology. 1: 500-6. PMID 10587646 DOI: 10.1038/70293  0.421
1999 Hill MM, Clark SF, Tucker DF, Birnbaum MJ, James DE, Macaulay SL. A role for protein kinase Bβ/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes Molecular and Cellular Biology. 19: 7771-7781. PMID 10523666 DOI: 10.1128/Mcb.19.11.7771  0.534
1999 Hausdorff SF, Fingar DC, Morioka K, Garza LA, Whiteman EL, Summers SA, Birnbaum MJ. Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation. The Journal of Biological Chemistry. 274: 24677-84. PMID 10455135 DOI: 10.1074/Jbc.274.35.24677  0.525
1999 Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, Meinkoth JL. Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation Molecular and Cellular Biology. 19: 5882-5891. PMID 10454535 DOI: 10.1128/Mcb.19.9.5882  0.402
1999 Summers SA, Whiteman EL, Cho H, Lipfert L, Birnbaum MJ. Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes Journal of Biological Chemistry. 274: 23858-23867. PMID 10446150 DOI: 10.1074/Jbc.274.34.23858  0.554
1999 Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE, Birnbaum MJ. The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. The Journal of Biological Chemistry. 274: 17934-40. PMID 10364240 DOI: 10.1074/Jbc.274.25.17934  0.544
1999 Li HL, Davis WW, Whiteman EL, Birnbaum MJ, Puré E. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 96: 6890-5. PMID 10359809 DOI: 10.1073/Pnas.96.12.6890  0.424
1998 Summers SA, Garza LA, Zhou H, Birnbaum MJ. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide Molecular and Cellular Biology. 18: 5457-5464. PMID 9710629 DOI: 10.1128/Mcb.18.9.5457  0.553
1998 Zhou H, Summers SA, Birnbaum MJ, Pittman RN. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. The Journal of Biological Chemistry. 273: 16568-75. PMID 9632728 DOI: 10.1074/Jbc.273.26.16568  0.469
1998 Brozinick JT, Birnbaum MJ. Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle Journal of Biological Chemistry. 273: 14679-14682. PMID 9614064 DOI: 10.1074/Jbc.273.24.14679  0.521
1998 Summers SA, Lipfert L, Birnbaum MJ. Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner Biochemical and Biophysical Research Communications. 246: 76-81. PMID 9600071 DOI: 10.1006/Bbrc.1998.8575  0.431
1998 Kohn AD, Barthel A, Kovacina KS, Boge A, Wallach B, Summers SA, Birnbaum MJ, Scott PH, Lawrence JC, Roth RA. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. The Journal of Biological Chemistry. 273: 11937-43. PMID 9565622 DOI: 10.1074/Jbc.273.19.11937  0.491
1998 Calera MR, Martinez C, Liu H, Jack AK, Birnbaum MJ, Pilch PF. Insulin increases the association of Akt-2 with Glut4-containing vesicles. The Journal of Biological Chemistry. 273: 7201-4. PMID 9516411 DOI: 10.1074/Jbc.273.13.7201  0.485
1998 Seidner G, Alvarez MG, Yeh JI, O'Driscoll KR, Klepper J, Stump TS, Wang D, Spinner NB, Birnbaum MJ, De Vivo DC. GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood- brain barrier hexose carrier Nature Genetics. 18: 188-191. PMID 9462754 DOI: 10.1038/Ng0298-188  0.351
1997 Summers SA, Birnbaum MJ. A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake Biochemical Society Transactions. 25: 981-988. PMID 9388586 DOI: 10.1042/Bst0250981  0.524
1997 Guillam MT, Hümmler E, Schaerer E, Wu JY, Birnbaum MJ, Beermann F, Schmidt A, Dériaz N, Thorens B. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 Nature Genetics. 17: 327-330. PMID 9354799 DOI: 10.1038/Ng1197-327  0.473
1997 Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (New York, N.Y.). 275: 661-5. PMID 9005851 DOI: 10.1126/Science.275.5300.661  0.414
1997 Birnbaum M. PI3- KINASE-DEPENDENT PATHWAYS REGULATING GLUT4 TRANSLOCATION Biochemical Society Transactions. 25: 461S-461S. DOI: 10.1042/Bst025461Sa  0.416
1996 Kohn AD, Summers SA, Birnbaum MJ, Roth RA. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. The Journal of Biological Chemistry. 271: 31372-8. PMID 8940145 DOI: 10.1074/Jbc.271.49.31372  0.534
1996 Hausdorff SF, Fingar DC, Birnbaum MJ. Signalling pathways mediating insulin-activated glucose transport Seminars in Cell and Developmental Biology. 7: 239-247. DOI: 10.1006/Scdb.1996.0032  0.547
1995 Young AT, Dahl J, Hausdorff SF, Bauer PH, Birnbaum MJ, Benjamin TL. Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter. Proceedings of the National Academy of Sciences of the United States of America. 92: 11613-7. PMID 8524814 DOI: 10.1073/Pnas.92.25.11613  0.416
1995 Yeh JI, Gulve EA, Rameh L, Birnbaum MJ. The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport Journal of Biological Chemistry. 270: 2107-2111. PMID 7836438 DOI: 10.1074/Jbc.270.5.2107  0.502
1995 Hausdorff SF, Bennett AM, Neel BG, Birnbaum MJ. Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation Journal of Biological Chemistry. 270: 12965-12968. PMID 7768884 DOI: 10.1074/Jbc.270.22.12965  0.529
1995 Verhey KJ, Yeh JI, Birnbaum MJ. Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment Journal of Cell Biology. 130: 1071-1079. PMID 7657693 DOI: 10.1083/Jcb.130.5.1071  0.711
1995 Yen JI, Verhey KJ, Birnbaum MJ. Kinetic analysis of glucose transporter trafficking in fibroblasts and adipocytes Biochemistry. 34: 15523-15531. PMID 7492554 DOI: 10.1021/Bi00047A018  0.684
1995 Birnbaum MJ, James DE. The insulin-regulatable glucose transporter GLUT-4 Current Opinion in Endocrinology & Diabetes. 2: 383-391. DOI: 10.1097/00060793-199510000-00003  0.476
1995 Verhey K, Yeh J, Birnbaum M. GLUT-4 targeting: lessons from insulin-responsive cells Trends in Cell Biology. 5: 451. DOI: 10.1016/S0962-8924(00)89110-2  0.681
1995 Verhey KJ, Yeh JI, Birnbaum MJ. GLUT-4 targeting: lessons from insulin-responsive cells Trends in Cell Biology. 5: 451.  0.348
1994 Garvey WT, Birnbaum MJ. Cellular insulin action and insulin resistance. Bailliere's Clinical Endocrinology and Metabolism. 7: 785-873. PMID 8304915 DOI: 10.1016/S0950-351X(05)80237-X  0.452
1994 Fingar DC, Birnbaum MJ. Characterization of the mitogen-activated protein kinase/90-kilodalton ribosomal protein S6 kinase signaling pathway in 3T3-L1 adipocytes and its role in insulin-stimulated glucose transport. Endocrinology. 134: 728-35. PMID 8299568 DOI: 10.1210/Endo.134.2.8299568  0.541
1994 Hausdorff SF, Frangioni JV, Birnbaum MJ. Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes Journal of Biological Chemistry. 269: 21391-21394. PMID 8063767  0.425
1994 Chuang LM, Hausdorff SF, Myers MG, White MF, Birnbaum MJ, Kahn CR. Interactive roles of ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes Journal of Biological Chemistry. 269: 27645-27649. PMID 7961682  0.411
1993 Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653  0.479
1993 Hudson AW, Fingar DC, Seidner GA, Griffiths G, Burke B, Birnbaum MJ. Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells. The Journal of Cell Biology. 122: 579-88. PMID 8335686 DOI: 10.1083/Jcb.122.3.579  0.492
1993 Verhey KJ, Hausdorff SF, Birnbaum MJ. Identification of the carboxy terminus as important for the isoform-specific subcellular targeting of glucose transporter proteins. The Journal of Cell Biology. 123: 137-47. PMID 7691826 DOI: 10.1083/Jcb.123.1.137  0.662
1993 Chuang LM, Myers MG, Seidner GA, Birnbaum MJ, White MF, Kahn CR. Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 90: 5172-5. PMID 7685118 DOI: 10.1073/Pnas.90.11.5172  0.497
1992 Hudson AW, Ruiz M, Birnbaum MJ. Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts. The Journal of Cell Biology. 116: 785-97. PMID 1309819 DOI: 10.1083/Jcb.116.3.785  0.448
1992 Birnbaum MJ. The insulin-sensitive glucose transporter. International Review of Cytology-a Survey of Cell Biology. 137: 239-297. DOI: 10.1016/S0074-7696(08)62678-9  0.505
1991 Garvey WT, Maianu L, Huecksteadt TP, Birnbaum MJ, Molina JM, Ciaraldi TP. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. The Journal of Clinical Investigation. 87: 1072-81. PMID 1999488 DOI: 10.1172/Jci115068  0.476
1990 Hiraki Y, McMorrow IM, Birnbaum MJ. The regulation of glucose transporter gene expression by cyclic adenosine monophosphate in NIH3T3 fibroblasts. Molecular Endocrinology (Baltimore, Md.). 3: 1470-6. PMID 2481819 DOI: 10.1210/Mend-3-9-1470  0.359
1989 Hiraki Y, Garcia de Herreros A, Birnbaum MJ. Transformation stimulates glucose transporter gene expression in the absence of protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 86: 8252-6. PMID 2682641 DOI: 10.1073/Pnas.86.21.8252  0.398
1989 Garvey WT, Huecksteadt TP, Lima FB, Birnbaum MJ. Expression of a glucose transporter gene cloned from brain in cellular models of insulin resistance: Dexamethasone decreases transporter mRNA in primary cultured adipocytes Molecular Endocrinology. 3: 1132-1141. PMID 2677680 DOI: 10.1210/mend-3-7-1132  0.315
1989 Garvey WT, Huecksteadt TP, Birnbaum MJ. Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus Science. 245: 60-63. PMID 2662408 DOI: 10.1126/Science.2662408  0.467
1989 Birnbaum MJ. Identification of a novel gene encoding an insulin-responsive glucose transporter protein Cell. 57: 305-315. PMID 2649253 DOI: 10.1016/0092-8674(89)90968-9  0.483
1987 Birnbaum MJ, Haspel HC, Rosen OM. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription Science. 235: 1495-1498. PMID 3029870 DOI: 10.1126/Science.3029870  0.59
1986 Birnbaum MJ, Haspel HC, Rosen OM. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein Proceedings of the National Academy of Sciences of the United States of America. 83: 5784-5788. PMID 3016720 DOI: 10.1073/Pnas.83.16.5784  0.593
1986 Petruzzelli L, Herrera R, Arenas-Garcia R, Fernandez R, Birnbaum MJ, Rosen OM. Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody Proceedings of the National Academy of Sciences of the United States of America. 83: 4710-4714. PMID 3014506 DOI: 10.1073/Pnas.83.13.4710  0.648
1986 Slater EP, Anderson T, Cattini P, Isaacs R, Birnbaum MJ, Gardner DG, Eberhardt NL, Baxter JD. Mechanisms of glucocorticoid hormone action. Advances in Experimental Medicine and Biology. 196: 67-80. PMID 3012984 DOI: 10.1007/978-1-4684-5101-6_5  0.495
1984 Lan NC, Karin M, Nguyen T, Weisz A, Birnbaum MJ, Eberhardt NL, Baxter JD. Mechanisms of glucocorticoid hormone action. Journal of Steroid Biochemistry. 20: 77-88. PMID 6368989 DOI: 10.1016/0022-4731(84)90192-4  0.519
1976 Birnbaum MJ, Schultz J, Fain JN. Hormone stimulated glycogenolysis in isolated goldfish hepatocytes American Journal of Physiology. 231: 191-197. PMID 183509 DOI: 10.1152/Ajplegacy.1976.231.1.191  0.471
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