| Year |
Citation |
Score |
| 2022 |
Wu Meyers N, Karasik A, Kaitany K, Fierke CA, Koutmos M. Gambogic acid and juglone inhibit RNase P through distinct mechanisms. The Journal of Biological Chemistry. 102683. PMID 36370850 DOI: 10.1016/j.jbc.2022.102683 |
0.332 |
|
| 2021 |
Si D, Nie G, Hurst TK, Fierke CA, Kopelman R. Combining Active Carbonic Anhydrase with Nanogels: Enzyme Protection and Zinc Sensing. International Journal of Nanomedicine. 16: 6645-6660. PMID 34611401 DOI: 10.2147/IJN.S321099 |
0.791 |
|
| 2020 |
Teramoto T, Kaitany KJ, Kakuta Y, Kimura M, Fierke CA, Hall TMT. Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA. Nucleic Acids Research. PMID 32719843 DOI: 10.1093/Nar/Gkaa627 |
0.398 |
|
| 2019 |
Sahoo BR, Bekier ME, Liu Z, Kocman V, Stoddard AK, Anantharamaiah GM, Nowick J, Fierke CA, Wang Y, Ramamoorthy A. Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers. Journal of Molecular Biology. PMID 31866295 DOI: 10.1016/J.Jmb.2019.12.005 |
0.45 |
|
| 2019 |
Welker Leng K, Castaneda CA, Decroos C, Islam B, Haider S, Christianson DW, Fierke CA. Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant. Biochemistry. PMID 31633931 DOI: 10.1021/Acs.Biochem.9B00653 |
0.437 |
|
| 2019 |
Karasik A, Fierke CA, Koutmos M. Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P. Rna (New York, N.Y.). PMID 31455609 DOI: 10.1261/Rna.069310.118 |
0.317 |
|
| 2019 |
García-Torres D, Fierke CA. The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases. The Journal of Biological Chemistry. PMID 31197034 DOI: 10.1074/Jbc.Ra119.007438 |
0.418 |
|
| 2019 |
Sahoo BR, Genjo T, Nakayama TW, Stoddard AK, Ando T, Yasuhara K, Fierke CA, Ramamoorthy A. A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation. Chemical Science. 10: 3976-3986. PMID 31015938 DOI: 10.1039/C8Sc05771K |
0.438 |
|
| 2018 |
Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A. Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs. Chemical Communications (Cambridge, England). PMID 30379172 DOI: 10.1039/C8Cc07921H |
0.435 |
|
| 2018 |
Sahoo BR, Genjo T, Cox SJ, Stoddard AK, Anantharamaiah GM, Fierke C, Ramamoorthy A. Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation. Journal of Molecular Biology. PMID 30170005 DOI: 10.1016/J.Jmb.2018.08.018 |
0.477 |
|
| 2018 |
Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127017 DOI: 10.1073/Pnas.1806202115 |
0.356 |
|
| 2018 |
Jennings BC, Lawton A, Rizk Z, Fierke CA. SmgGDS-607 regulation of RhoA GTPase prenylation is nucleotide dependent. Biochemistry. PMID 29940100 DOI: 10.1021/Acs.Biochem.8B00567 |
0.405 |
|
| 2017 |
Liu X, Chen Y, Fierke CA. Inner-sphere Coordination of Divalent Metal Ion with Nucleobase in Catalytic RNA. Journal of the American Chemical Society. PMID 29116782 DOI: 10.1021/Jacs.7B08755 |
0.49 |
|
| 2017 |
Castaneda CA, Wolfson NA, Leng KR, Kuo YM, Andrews AJ, Fierke CA. Histone deacetylase 8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared to peptides. The Journal of Biological Chemistry. PMID 29109148 DOI: 10.1074/Jbc.M117.811026 |
0.698 |
|
| 2017 |
Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA. HDAC8 substrates identified by genetically-encoded active site photocrosslinking. Journal of the American Chemical Society. PMID 29035536 DOI: 10.1021/Jacs.7B07603 |
0.763 |
|
| 2017 |
Niu S, Kim BC, Fierke CA, Ruotolo BT. Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1. International Journal of Mass Spectrometry. 420: 9-15. PMID 28983190 DOI: 10.1016/J.Ijms.2016.12.017 |
0.394 |
|
| 2017 |
Castaneda CA, Lopez JE, Joseph CG, Scholle MD, Mrksich M, Fierke CA. Active site metal identity alters HDAC8 substrate selectivity: A potential novel regulatory mechanism. Biochemistry. PMID 28937750 DOI: 10.1021/Acs.Biochem.7B00851 |
0.807 |
|
| 2017 |
Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJ, Jackson ND, Koutmos M, Fierke CA. Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P. Rna (New York, N.Y.). PMID 28874505 DOI: 10.1261/Rna.061457.117 |
0.828 |
|
| 2017 |
Thompson RB, Fierke CA. Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues. Methods in Enzymology. 589: 281-299. PMID 28336067 DOI: 10.1016/Bs.Mie.2017.01.003 |
0.335 |
|
| 2017 |
Chen Y, Liu X, Wu N, Fierke CA. Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors. Methods in Molecular Biology (Clifton, N.J.). 1520: 201-225. PMID 27873254 DOI: 10.1007/978-1-4939-6634-9_12 |
0.485 |
|
| 2016 |
Temple KJ, Wright EN, Fierke CA, Gibbs RA. Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues. Organic Letters. 18: 6038-6041. PMID 27934359 DOI: 10.1021/Acs.Orglett.6B02977 |
0.453 |
|
| 2016 |
Temple KJ, Wright EN, Fierke CA, Gibbs RA. Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27342751 DOI: 10.1016/J.Bmcl.2016.06.035 |
0.503 |
|
| 2016 |
Temple KJ, Wright EN, Fierke CA, Gibbs RA. Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27342750 DOI: 10.1016/J.Bmcl.2016.06.034 |
0.498 |
|
| 2016 |
Klemm BP, Wu N, Chen Y, Liu X, Kaitany KJ, Howard MJ, Fierke CA. The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions. Biomolecules. 6. PMID 27187488 DOI: 10.3390/biom6020027 |
0.813 |
|
| 2016 |
Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M. Differential substrate recognition by isozymes of plant protein-only Ribonuclease P. Rna (New York, N.Y.). PMID 26966150 DOI: 10.1261/Rna.055541.115 |
0.832 |
|
| 2016 |
Alam N, Zimmerman L, Wolfson NA, Joseph CG, Fierke CA, Schueler-Furman O. Structure-Based Identification of HDAC8 Non-histone Substrates. Structure (London, England : 1993). 24: 458-68. PMID 26933971 DOI: 10.1016/J.Str.2016.02.002 |
0.741 |
|
| 2016 |
Lopez JE, Sullivan ED, Fierke CA. Metal-dependent deacetylases: Cancer and epigenetic regulators. Acs Chemical Biology. PMID 26907466 DOI: 10.1021/Acschembio.5B01067 |
0.723 |
|
| 2016 |
Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL. The Tumor Suppressive Small GTPase DiRas1 Binds the Non-canonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. The Journal of Biological Chemistry. PMID 26814130 DOI: 10.1074/Jbc.M115.696831 |
0.311 |
|
| 2016 |
Gantt SM, Decroos C, Lee MS, Gullett LE, Bowman CM, Christianson DW, Fierke CA. General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry. PMID 26806311 DOI: 10.1021/Acs.Biochem.5B01327 |
0.378 |
|
| 2016 |
Pithadia A, Brender JR, Fierke CA, Ramamoorthy A. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. Journal of Diabetes Research. 2016: 2046327. PMID 26649317 DOI: 10.1155/2016/2046327 |
0.456 |
|
| 2016 |
Pithadia AS, Bhunia A, Sribalan R, Padmini V, Fierke CA, Ramamoorthy A. Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chemical Communications (Cambridge, England). 52: 942-5. PMID 26587568 DOI: 10.1039/C5Cc07792C |
0.446 |
|
| 2015 |
Jennings BC, Danowitz AM, Wang YC, Gibbs RA, Distefano MD, Fierke CA. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorganic & Medicinal Chemistry Letters. PMID 26803203 DOI: 10.1016/J.Bmcl.2015.12.079 |
0.532 |
|
| 2015 |
Karasik A, Shanmuganathan A, Howard MJ, Fierke CA, Koutmos M. Nuclear Protein-only ribonuclease P 2 Structure and Biochemical Characterization Provide Insight Into the Conserved Properties of tRNA 5'-end Processing Enzymes. Journal of Molecular Biology. PMID 26655022 DOI: 10.1016/J.Jmb.2015.11.025 |
0.434 |
|
| 2015 |
Daniel KB, Sullivan ED, Chen Y, Chan JC, Jennings PA, Fierke CA, Cohen SM. Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. Journal of Medicinal Chemistry. 58: 4812-21. PMID 25974739 DOI: 10.1021/Acs.Jmedchem.5B00539 |
0.327 |
|
| 2015 |
Howard MJ, Klemm BP, Fierke CA. Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P. The Journal of Biological Chemistry. 290: 13454-64. PMID 25817998 DOI: 10.1074/Jbc.M115.644831 |
0.827 |
|
| 2015 |
Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A. Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. Biochemistry. 54: 2249-2261. PMID 25785896 DOI: 10.1021/Acs.Biochem.5B00061 |
0.494 |
|
| 2015 |
Mustoe AM, Liu X, Lin PJ, Al-Hashimi HM, Fierke CA, Brooks CL. Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding. Journal of the American Chemical Society. 137: 3592-9. PMID 25705930 DOI: 10.1021/Ja5130308 |
0.587 |
|
| 2015 |
Kim B, Pithadia AS, Fierke CA. Kinetics and thermodynamics of metal-binding to histone deacetylase 8. Protein Science : a Publication of the Protein Society. 24: 354-65. PMID 25516458 DOI: 10.1002/Pro.2623 |
0.352 |
|
| 2015 |
Dostál L, Kohler WM, Penner-Hahn JE, Miller RA, Fierke CA. Fibroblasts from long-lived rodent species exclude cadmium. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 10-9. PMID 24522391 DOI: 10.1093/Gerona/Glu001 |
0.507 |
|
| 2015 |
Matveeva EG, Franke G, Bourne L, Stoddard AK, Fierke CA, Thompson RB. Ratiometric Bioluminescence-Based Zinc Biosensor with Nanomolar Sensitivity Biophysical Journal. 108: 492. DOI: 10.1016/J.Bpj.2014.11.2690 |
0.308 |
|
| 2014 |
Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy. The Journal of Physical Chemistry Letters. 5: 1864-70. PMID 26273866 DOI: 10.1021/Jz5001775 |
0.49 |
|
| 2014 |
Liu X, Chen Y, Fierke CA. A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P. Nucleic Acids Research. 42: e159. PMID 25249623 DOI: 10.1093/Nar/Gku850 |
0.479 |
|
| 2014 |
Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, ... ... Fierke CA, et al. An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. Acs Chemical Biology. 9: 2210-6. PMID 25089360 DOI: 10.1021/Cb500492R |
0.333 |
|
| 2014 |
Wang N, Lodge JM, Fierke CA, Mapp AK. Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand. Proceedings of the National Academy of Sciences of the United States of America. 111: 12061-6. PMID 25049401 DOI: 10.1073/Pnas.1406033111 |
0.354 |
|
| 2014 |
Wolfson NA, Pitcairn CA, Sullivan ED, Joseph CG, Fierke CA. An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity. Analytical Biochemistry. 456: 61-9. PMID 24674948 DOI: 10.1016/J.Ab.2014.03.012 |
0.747 |
|
| 2014 |
McCranor BJ, Szmacinski H, Zeng HH, Stoddard AK, Hurst T, Fierke CA, Lakowicz JR, Thompson RB. Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor. Metallomics : Integrated Biometal Science. 6: 1034-42. PMID 24671220 DOI: 10.1039/C3Mt00305A |
0.787 |
|
| 2014 |
Daniels KG, Tonthat NK, McClure DR, Chang YC, Liu X, Schumacher MA, Fierke CA, Schmidler SC, Oas TG. Ligand concentration regulates the pathways of coupled protein folding and binding. Journal of the American Chemical Society. 136: 822-5. PMID 24364358 DOI: 10.1021/Ja4086726 |
0.409 |
|
| 2014 |
Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: Finding answers through NMR spectroscopy Journal of Physical Chemistry Letters. 5: 1864-1870. DOI: 10.1021/jz5001775 |
0.399 |
|
| 2013 |
Parisien M, Wang X, Perdrizet G, Lamphear C, Fierke CA, Maheshwari KC, Wilde MJ, Sosnick TR, Pan T. Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. Cell Reports. 3: 1703-13. PMID 23665222 DOI: 10.1016/J.Celrep.2013.04.010 |
0.794 |
|
| 2013 |
Howard MJ, Liu X, Lim WH, Klemm BP, Fierke CA, Koutmos M, Engelke DR. RNase P enzymes: divergent scaffolds for a conserved biological reaction. Rna Biology. 10: 909-14. PMID 23595059 DOI: 10.4161/Rna.24513 |
0.811 |
|
| 2013 |
Wang D, Fierke CA. The BaeSR regulon is involved in defense against zinc toxicity in E. coli. Metallomics : Integrated Biometal Science. 5: 372-83. PMID 23446818 DOI: 10.1039/C3Mt20217H |
0.519 |
|
| 2013 |
Zeng HH, Matveeva EG, Stoddard AK, Fierke CA, Thompson RB. Long wavelength fluorescence ratiometric zinc biosensor. Journal of Fluorescence. 23: 375-9. PMID 23345045 DOI: 10.1007/S10895-013-1161-6 |
0.302 |
|
| 2013 |
Wolfson NA, Pitcairn CA, Fierke CA. HDAC8 substrates: Histones and beyond. Biopolymers. 99: 112-26. PMID 23175386 DOI: 10.1002/Bip.22135 |
0.393 |
|
| 2012 |
Zverina EA, Lamphear CL, Wright EN, Fierke CA. Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions. Current Opinion in Chemical Biology. 16: 544-52. PMID 23141597 DOI: 10.1016/J.Cbpa.2012.10.015 |
0.798 |
|
| 2012 |
Hougland JL, Gangopadhyay SA, Fierke CA. Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. The Journal of Biological Chemistry. 287: 38090-100. PMID 22992747 DOI: 10.1074/Jbc.M112.404954 |
0.806 |
|
| 2012 |
Howard MJ, Lim WH, Fierke CA, Koutmos M. Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing. Proceedings of the National Academy of Sciences of the United States of America. 109: 16149-54. PMID 22991464 DOI: 10.1073/Pnas.1209062109 |
0.654 |
|
| 2012 |
Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP. Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. Biochemistry. 51: 8307-19. PMID 22989235 DOI: 10.1021/Bi3011362 |
0.824 |
|
| 2012 |
Wang D, Hosteen O, Fierke CA. ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc. Journal of Inorganic Biochemistry. 111: 173-81. PMID 22459916 DOI: 10.1016/J.Jinorgbio.2012.02.008 |
0.508 |
|
| 2012 |
Cheriyan M, Toone EJ, Fierke CA. Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates. Biochemistry. 51: 1658-68. PMID 22316217 DOI: 10.1021/Bi201899B |
0.802 |
|
| 2012 |
Yang Y, Wang B, Ucisik MN, Cui G, Fierke CA, Merz KM. Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS. Journal of the American Chemical Society. 134: 820-3. PMID 22206225 DOI: 10.1021/Ja209650H |
0.356 |
|
| 2012 |
Wang Y, Liu X, Schneider B, Zverina EA, Russ K, Wijeyesakere SJ, Fierke CA, Richardson RJ, Philbert MA. Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 509-21. PMID 22106038 DOI: 10.1093/Toxsci/Kfr317 |
0.371 |
|
| 2011 |
Guan X, Fierke CA. Understanding Protein Palmitoylation: Biological Significance and Enzymology. Science China. Chemistry. 54: 1888-1897. PMID 25419213 DOI: 10.1007/S11426-011-4428-2 |
0.581 |
|
| 2011 |
London N, Lamphear CL, Hougland JL, Fierke CA, Schueler-Furman O. Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. Plos Computational Biology. 7: e1002170. PMID 21998565 DOI: 10.1371/Journal.Pcbi.1002170 |
0.796 |
|
| 2011 |
Cheriyan M, Walters MJ, Kang BD, Anzaldi LL, Toone EJ, Fierke CA. Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate. Bioorganic & Medicinal Chemistry. 19: 6447-53. PMID 21944547 DOI: 10.1016/J.Bmc.2011.08.056 |
0.786 |
|
| 2011 |
Wang D, Hurst TK, Thompson RB, Fierke CA. Genetically encoded ratiometric biosensors to measure intracellular exchangeable zinc in Escherichia coli. Journal of Biomedical Optics. 16: 087011. PMID 21895338 DOI: 10.1117/1.3613926 |
0.789 |
|
| 2011 |
Marvin MC, Walker SC, Fierke CA, Engelke DR. Binding and cleavage of unstructured RNA by nuclear RNase P. Rna (New York, N.Y.). 17: 1429-40. PMID 21665997 DOI: 10.1261/Rna.2633611 |
0.365 |
|
| 2011 |
Koutmou KS, Day-Storms JJ, Fierke CA. The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer. Rna (New York, N.Y.). 17: 1225-35. PMID 21622899 DOI: 10.1261/Rna.2742511 |
0.437 |
|
| 2011 |
Haider S, Joseph CG, Neidle S, Fierke CA, Fuchter MJ. On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorganic & Medicinal Chemistry Letters. 21: 2129-32. PMID 21320778 DOI: 10.1016/J.Bmcl.2011.01.128 |
0.699 |
|
| 2011 |
Wands AM, Wang N, Lum JK, Hsieh J, Fierke CA, Mapp AK. Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator. The Journal of Biological Chemistry. 286: 16238-45. PMID 21317429 DOI: 10.1074/Jbc.M110.207589 |
0.321 |
|
| 2011 |
Cole KE, Gattis SG, Angell HD, Fierke CA, Christianson DW. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 . Biochemistry. 50: 258-65. PMID 21171638 DOI: 10.1021/Bi101622A |
0.809 |
|
| 2011 |
McCranor BJ, Zeng H, Szmacinski H, Fierke CA, Lakowicz JR, Thompson RB. Flim of Physiological Free CU(II) in Living Cells with a Protein-Based Biosensor Biophysical Journal. 100: 470a. DOI: 10.1016/J.Bpj.2010.12.2758 |
0.322 |
|
| 2011 |
Lamphear CL, Zverina EA, Hougland JL, Fierke CA. Global Identification of Protein Prenyltransferase Substrates. Defining the Prenylated Proteome. Enzymes. 29: 207-234. DOI: 10.1016/B978-0-12-381339-8.00012-3 |
0.8 |
|
| 2010 |
Gattis SG, Hernick M, Fierke CA. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions. The Journal of Biological Chemistry. 285: 33788-96. PMID 20709752 DOI: 10.1074/Jbc.M110.147173 |
0.798 |
|
| 2010 |
Dowling DP, Gattis SG, Fierke CA, Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Biochemistry. 49: 5048-56. PMID 20545365 DOI: 10.1021/Bi1005046 |
0.813 |
|
| 2010 |
Hsieh J, Koutmou KS, Rueda D, Koutmos M, Walter NG, Fierke CA. A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P. Journal of Molecular Biology. 400: 38-51. PMID 20434461 DOI: 10.1016/J.Jmb.2010.04.050 |
0.477 |
|
| 2010 |
Hernick M, Gattis SG, Penner-Hahn JE, Fierke CA. Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity. Biochemistry. 49: 2246-55. PMID 20136146 DOI: 10.1021/Bi902066T |
0.802 |
|
| 2010 |
Koutmou KS, Casiano-Negroni A, Getz MM, Pazicni S, Andrews AJ, Penner-Hahn JE, Al-Hashimi HM, Fierke CA. NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proceedings of the National Academy of Sciences of the United States of America. 107: 2479-84. PMID 20133747 DOI: 10.1073/Pnas.0906319107 |
0.8 |
|
| 2010 |
Gantt SL, Joseph CG, Fierke CA. Activation and inhibition of histone deacetylase 8 by monovalent cations. The Journal of Biological Chemistry. 285: 6036-43. PMID 20029090 DOI: 10.1074/Jbc.M109.033399 |
0.805 |
|
| 2010 |
Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA. Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates. Bioorganic & Medicinal Chemistry Letters. 20: 767-70. PMID 20005705 DOI: 10.1016/J.Bmcl.2009.11.011 |
0.734 |
|
| 2010 |
Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. Journal of Molecular Biology. 396: 195-208. PMID 19932118 DOI: 10.1016/J.Jmb.2009.11.039 |
0.77 |
|
| 2010 |
Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA. Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. Journal of Molecular Biology. 395: 176-90. PMID 19878682 DOI: 10.1016/J.Jmb.2009.10.038 |
0.815 |
|
| 2010 |
Hurst TK, Wang D, Thompson RB, Fierke CA. Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochimica Et Biophysica Acta. 1804: 393-403. PMID 19818877 DOI: 10.1016/J.Bbapap.2009.09.031 |
0.787 |
|
| 2009 |
Hsieh J, Fierke CA. Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate. Rna (New York, N.Y.). 15: 1565-77. PMID 19549719 DOI: 10.1261/Rna.1639409 |
0.437 |
|
| 2009 |
Hougland JL, Fierke CA. Getting a handle on protein prenylation. Nature Chemical Biology. 5: 197-8. PMID 19295521 DOI: 10.1038/Nchembio0409-197 |
0.69 |
|
| 2009 |
Hougland JL, Lamphear CL, Scott SA, Gibbs RA, Fierke CA. Context-dependent substrate recognition by protein farnesyltransferase. Biochemistry. 48: 1691-701. PMID 19199818 DOI: 10.1021/Bi801710G |
0.814 |
|
| 2009 |
Hsieh J, Walker SC, Fierke CA, Engelke DR. Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. Rna (New York, N.Y.). 15: 224-34. PMID 19095620 DOI: 10.1261/Rna.1309409 |
0.399 |
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| 2008 |
Bozym R, Hurst TK, Westerberg N, Stoddard A, Fierke CA, Frederickson CJ, Thompson RB. Determination of zinc using carbonic anhydrase-based fluorescence biosensors. Methods in Enzymology. 450: 287-309. PMID 19152866 DOI: 10.1016/S0076-6879(08)03414-9 |
0.759 |
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| 2008 |
Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 47: 13554-63. PMID 19053282 DOI: 10.1021/Bi801610C |
0.806 |
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| 2008 |
Lipton AS, Heck RW, Hernick M, Fierke CA, Ellis PD. Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy. Journal of the American Chemical Society. 130: 12671-9. PMID 18761443 DOI: 10.1021/Ja801776C |
0.311 |
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| 2008 |
Mason AB, Judson GL, Bravo MC, Edelstein A, Byrne SL, James NG, Roush ED, Fierke CA, Bobst CE, Kaltashov IA, Daughtery MA. Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. Biochemistry. 47: 9847-55. PMID 18712936 DOI: 10.1021/Bi801133D |
0.326 |
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| 2008 |
Walters MJ, Srikannathasan V, McEwan AR, Naismith JH, Fierke CA, Toone EJ. Characterization and crystal structure of Escherichia coli KDPGal aldolase. Bioorganic & Medicinal Chemistry. 16: 710-20. PMID 17981470 DOI: 10.1016/J.Bmc.2007.10.043 |
0.402 |
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| 2008 |
Andrews AJ, Fierke C. Measuring the Stoichiometry of Magnesium Ions Bound to RNA Handbook of Rna Biochemistry. 250-258. DOI: 10.1002/9783527619504.ch16 |
0.6 |
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| 2007 |
Inamdar MV, Lastoskie CM, Fierke CA, Sastry AM. Mobile trap algorithm for zinc detection using protein sensors. The Journal of Chemical Physics. 127: 185102. PMID 18020665 DOI: 10.1063/1.2778684 |
0.306 |
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| 2007 |
Cheriyan M, Toone EJ, Fierke CA. Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates. Protein Science : a Publication of the Protein Society. 16: 2368-77. PMID 17962400 DOI: 10.1110/Ps.073042907 |
0.804 |
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| 2007 |
Smith JK, Hsieh J, Fierke CA. Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis. Biopolymers. 87: 329-38. PMID 17868095 DOI: 10.1002/Bip.20846 |
0.413 |
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| 2007 |
Krzysiak AJ, Scott SA, Hicks KA, Fierke CA, Gibbs RA. Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries. Bioorganic & Medicinal Chemistry Letters. 17: 5548-51. PMID 17804232 DOI: 10.1016/J.Bmcl.2007.08.024 |
0.698 |
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| 2007 |
Krzysiak AJ, Rawat DS, Scott SA, Pais JE, Handley M, Harrison ML, Fierke CA, Gibbs RA. Combinatorial modulation of protein prenylation. Acs Chemical Biology. 2: 385-9. PMID 17530735 DOI: 10.1021/Cb700062B |
0.81 |
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| 2007 |
Niranjanakumari S, Day-Storms JJ, Ahmed M, Hsieh J, Zahler NH, Venters RA, Fierke CA. Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. Rna (New York, N.Y.). 13: 521-35. PMID 17299131 DOI: 10.1261/Rna.308707 |
0.432 |
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| 2007 |
Getz MM, Andrews AJ, Fierke CA, Al-Hashimi HM. Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. Rna (New York, N.Y.). 13: 251-66. PMID 17194721 DOI: 10.1261/Rna.264207 |
0.754 |
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| 2007 |
Pais JE, Fierke CA. Measurement of kinetic isotope effects to probe the reaction mechanism catalyzed by mammalian protein farnesyltransferase The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A275 |
0.804 |
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| 2007 |
Fierke CA, Herschlag D. The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond. [Current Opinion in Chemical Biology 2006, 10:453-454] (DOI:10.1016/j.cbpa.2006.08.019) Current Opinion in Chemical Biology. 11: 111. DOI: 10.1016/J.Cbpa.2006.11.001 |
0.469 |
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| 2006 |
Hernick M, Fierke CA. Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis. Biochemistry. 45: 15240-8. PMID 17176046 DOI: 10.1021/Bi061405K |
0.38 |
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| 2006 |
Johnson KM, Cleary J, Fierke CA, Opipari AW, Glick GD. Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase. Acs Chemical Biology. 1: 304-8. PMID 17163759 DOI: 10.1021/Cb600143J |
0.305 |
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| 2006 |
Bozym RA, Thompson RB, Stoddard AK, Fierke CA. Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor. Acs Chemical Biology. 1: 103-11. PMID 17163650 DOI: 10.1021/Cb500043A |
0.317 |
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| 2006 |
Hernick M, Fierke CA. Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions. Biochemistry. 45: 14573-81. PMID 17144651 DOI: 10.1021/Bi061625Y |
0.416 |
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| 2006 |
Pais JE, Bowers KE, Fierke CA. Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase. Journal of the American Chemical Society. 128: 15086-7. PMID 17117849 DOI: 10.1021/Ja065838M |
0.814 |
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| 2006 |
Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase. Biochemistry. 45: 7940-8. PMID 16800620 DOI: 10.1021/Bi060823M |
0.435 |
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| 2006 |
Gantt SL, Gattis SG, Fierke CA. Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. Biochemistry. 45: 6170-8. PMID 16681389 DOI: 10.1021/Bi060212U |
0.799 |
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| 2006 |
Xiao S, Hsieh J, Nugent RL, Coughlin DJ, Fierke CA, Engelke DR. Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP. Rna (New York, N.Y.). 12: 1023-37. PMID 16618965 DOI: 10.1261/Rna.23206 |
0.356 |
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| 2006 |
Fullerton SW, Griffiths JS, Merkel AB, Cheriyan M, Wymer NJ, Hutchins MJ, Fierke CA, Toone EJ, Naismith JH. Mechanism of the Class I KDPG aldolase. Bioorganic & Medicinal Chemistry. 14: 3002-10. PMID 16403639 DOI: 10.1016/J.Bmc.2005.12.022 |
0.8 |
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| 2006 |
Sumner JP, Westerberg NM, Stoddard AK, Hurst TK, Cramer M, Thompson RB, Fierke CA, Kopelman R. DsRed as a highly sensitive, selective, and reversible fluorescence-based biosensor for both Cu(+) and Cu(2+) ions. Biosensors & Bioelectronics. 21: 1302-8. PMID 16026976 DOI: 10.1016/J.Bios.2005.04.023 |
0.785 |
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| 2006 |
Sumner JP, Westerberg NM, Stoddard AK, Fierke CA, Kopelman R. Cu +- and Cu 2+-sensitive PEBBLE fluorescent nanosensors using DsRed as the recognition element Sensors and Actuators, B: Chemical. 113: 760-767. DOI: 10.1016/J.Snb.2005.07.028 |
0.78 |
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| 2006 |
Fierke CA, Herschlag D. The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond Mechanisms Current Opinion in Chemical Biology. 10: 453-454. DOI: 10.1016/J.Cbpa.2006.08.019 |
0.475 |
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| 2005 |
Rueda D, Hsieh J, Day-Storms JJ, Fierke CA, Walter NG. The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation. Biochemistry. 44: 16130-9. PMID 16331973 DOI: 10.1021/Bi0519093 |
0.432 |
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| 2005 |
Hicks KA, Hartman HL, Fierke CA. Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I. Biochemistry. 44: 15325-33. PMID 16285736 DOI: 10.1021/Bi050951V |
0.818 |
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| 2005 |
Hartman HL, Hicks KA, Fierke CA. Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity. Biochemistry. 44: 15314-24. PMID 16285735 DOI: 10.1021/Bi0509503 |
0.807 |
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| 2005 |
Pais JE, Bowers KE, Stoddard AK, Fierke CA. A continuous fluorescent assay for protein prenyltransferases measuring diphosphate release. Analytical Biochemistry. 345: 302-11. PMID 16143290 DOI: 10.1016/J.Ab.2005.07.040 |
0.814 |
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| 2005 |
Reigard SA, Zahn TJ, Haworth KB, Hicks KA, Fierke CA, Gibbs RA. Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase. Biochemistry. 44: 11214-23. PMID 16101305 DOI: 10.1021/Bi050725L |
0.713 |
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| 2005 |
Xiao S, Day-Storms JJ, Srisawat C, Fierke CA, Engelke DR. Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing. Rna (New York, N.Y.). 11: 885-96. PMID 15872187 DOI: 10.1261/Rna.7282205 |
0.354 |
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| 2005 |
Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism. The Journal of Biological Chemistry. 280: 16969-78. PMID 15705580 DOI: 10.1074/Jbc.M413560200 |
0.357 |
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| 2005 |
Hernick M, Fierke CA. Zinc hydrolases: the mechanisms of zinc-dependent deacetylases. Archives of Biochemistry and Biophysics. 433: 71-84. PMID 15581567 DOI: 10.1016/J.Abb.2004.08.006 |
0.388 |
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| 2005 |
Zeng HH, Bozym RA, Rosenthal RE, Fiskum G, Cotto-Cumba C, Westerberg N, Fierke CA, Stoddard A, Cramer ML, Frederickson CJ, Thompson R. In situ measurement of free zinc in an ischemia model and cell culture using a ratiometric fluorescence-based biosensor Progress in Biomedical Optics and Imaging - Proceedings of Spie. 5692: 51-59. DOI: 10.1117/12.614168 |
0.781 |
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| 2004 |
Day-Storms JJ, Niranjanakumari S, Fierke CA. Ionic interactions between PRNA and P protein in Bacillus subtilis RNase P characterized using a magnetocapture-based assay. Rna (New York, N.Y.). 10: 1595-608. PMID 15337847 DOI: 10.1261/Rna.7550104 |
0.394 |
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| 2004 |
Griffiths JS, Cheriyan M, Corbell JB, Pocivavsek L, Fierke CA, Toone EJ. A bacterial selection for the directed evolution of pyruvate aldolases. Bioorganic & Medicinal Chemistry. 12: 4067-74. PMID 15246084 DOI: 10.1016/J.Bmc.2004.05.034 |
0.785 |
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| 2004 |
Hartman HL, Bowers KE, Fierke CA. Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. The Journal of Biological Chemistry. 279: 30546-53. PMID 15131129 DOI: 10.1074/Jbc.M403469200 |
0.756 |
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| 2004 |
Bowers KE, Fierke CA. Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group. Biochemistry. 43: 5256-65. PMID 15122891 DOI: 10.1021/Bi049822P |
0.374 |
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| 2004 |
McCall KA, Fierke CA. Probing determinants of the metal ion selectivity in carbonic anhydrase using mutagenesis. Biochemistry. 43: 3979-86. PMID 15049705 DOI: 10.1021/Bi0498914 |
0.363 |
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| 2004 |
Hsieh J, Andrews AJ, Fierke CA. Roles of protein subunits in RNA-protein complexes: lessons from ribonuclease P. Biopolymers. 73: 79-89. PMID 14691942 DOI: 10.1002/Bip.10521 |
0.685 |
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| 2003 |
Zeng HH, Thompson RB, Maliwal BP, Fones GR, Moffett JW, Fierke CA. Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor. Analytical Chemistry. 75: 6807-12. PMID 14670039 DOI: 10.1021/Ac0345401 |
0.325 |
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| 2003 |
Pickett JS, Bowers KE, Fierke CA. Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand. The Journal of Biological Chemistry. 278: 51243-50. PMID 14532266 DOI: 10.1074/Jbc.M309226200 |
0.632 |
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| 2003 |
Tobin DA, Pickett JS, Hartman HL, Fierke CA, Penner-Hahn JE. Structural characterization of the zinc site in protein farnesyltransferase. Journal of the American Chemical Society. 125: 9962-9. PMID 12914459 DOI: 10.1021/Ja035927O |
0.801 |
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| 2003 |
Pickett JS, Bowers KE, Hartman HL, Fu HW, Embry AC, Casey PJ, Fierke CA. Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. Biochemistry. 42: 9741-8. PMID 12911316 DOI: 10.1021/Bi0346852 |
0.82 |
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| 2003 |
Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 8146-50. PMID 12819349 DOI: 10.1073/Pnas.1432990100 |
0.374 |
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| 2003 |
McClure CP, Rusche KM, Peariso K, Jackman JE, Fierke CA, Penner-Hahn JE. EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Journal of Inorganic Biochemistry. 94: 78-85. PMID 12620676 DOI: 10.1016/S0162-0134(02)00611-6 |
0.767 |
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| 2003 |
Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE. Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proceedings of the National Academy of Sciences of the United States of America. 100: 904-9. PMID 12538863 DOI: 10.1073/Pnas.252770599 |
0.367 |
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| 2003 |
Penner-Hahn JE, Tobin D, Matthews RG, Fierke CA, Peariso K, Grahame DA, Garrow TA. Zinc catalyzed alkyl-transfer enzymes Journal of Inorganic Biochemistry. 96: 58. DOI: 10.1016/S0162-0134(03)80504-4 |
0.566 |
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| 2002 |
Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. Journal of Medicinal Chemistry. 45: 4359-70. PMID 12213077 DOI: 10.1021/Jm020183V |
0.809 |
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| 2002 |
Thompson RB, Peterson D, Mahoney W, Cramer M, Maliwal BP, Suh SW, Frederickson C, Fierke C, Herman P. Fluorescent zinc indicators for neurobiology. Journal of Neuroscience Methods. 118: 63-75. PMID 12191759 DOI: 10.1016/S0165-0270(02)00144-9 |
0.351 |
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| 2002 |
Crary SM, Kurz JC, Fierke CA. Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P. Rna (New York, N.Y.). 8: 933-47. PMID 12166648 DOI: 10.1017/S1355838202025025 |
0.798 |
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| 2002 |
Kurz JC, Fierke CA. The affinity of magnesium binding sites in the Bacillus subtilis RNase P x pre-tRNA complex is enhanced by the protein subunit. Biochemistry. 41: 9545-58. PMID 12135377 DOI: 10.1021/Bi025553W |
0.788 |
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| 2002 |
Chehade KA, Kiegiel K, Isaacs RJ, Pickett JS, Bowers KE, Fierke CA, Andres DA, Spielmann HP. Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. Journal of the American Chemical Society. 124: 8206-19. PMID 12105898 DOI: 10.1021/Ja0124717 |
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| 2002 |
Xiao S, Scott F, Fierke CA, Engelke DR. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Annual Review of Biochemistry. 71: 165-89. PMID 12045094 DOI: 10.1146/Annurev.Biochem.71.110601.135352 |
0.398 |
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| 2002 |
Griffiths JS, Wymer NJ, Njolito E, Niranjanakumari S, Fierke CA, Toone EJ. Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase. Bioorganic & Medicinal Chemistry. 10: 545-50. PMID 11814840 DOI: 10.1016/S0968-0896(01)00307-8 |
0.385 |
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| 2002 |
Madder RD, Kim CY, Chandra PP, Doyon JB, Baird TA, Fierke CA, Christianson DW, Voet JG, Jain A. Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase. The Journal of Organic Chemistry. 67: 582-4. PMID 11798333 DOI: 10.1021/Jo0159385 |
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| 2001 |
Fierke CA, Thompson RB. Fluorescence-based biosensing of zinc using carbonic anhydrase. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 14: 205-22. PMID 11831457 DOI: 10.1023/A:1012980628412 |
0.378 |
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| 2001 |
Wymer N, Buchanan LV, Henderson D, Mehta N, Botting CH, Pocivavsek L, Fierke CA, Toone EJ, Naismith JH. Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. Structure (London, England : 1993). 9: 1-9. PMID 11342129 DOI: 10.1016/S0969-2126(00)00555-4 |
0.417 |
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| 2001 |
DiTusa CA, McCall KA, Christensen T, Mahapatro M, Fierke CA, Toone EJ. Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. Biochemistry. 40: 5345-51. PMID 11330997 DOI: 10.1021/Bi0017327 |
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| 2001 |
DiTusa CA, Christensen T, McCall KA, Fierke CA, Toone EJ. Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. Biochemistry. 40: 5338-44. PMID 11330996 DOI: 10.1021/Bi001731E |
0.368 |
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| 2001 |
Henkels CH, Kurz JC, Fierke CA, Oas TG. Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. Biochemistry. 40: 2777-89. PMID 11258888 DOI: 10.1021/Bi002078Y |
0.777 |
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| 2001 |
Fang XW, Yang XJ, Littrell K, Niranjanakumari S, Thiyagarajan P, Fierke CA, Sosnick TR, Pan T. The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits. Rna (New York, N.Y.). 7: 233-41. PMID 11233980 DOI: 10.1017/S1355838201001352 |
0.365 |
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| 2001 |
Hightower KE, Casey PJ, Fierke CA. Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. Biochemistry. 40: 1002-10. PMID 11170422 DOI: 10.1021/Bi002237D |
0.479 |
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| 2001 |
Jackman JE, Raetz CR, Fierke CA. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site. Biochemistry. 40: 514-23. PMID 11148046 DOI: 10.1021/Bi001872G |
0.765 |
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| 2000 |
Cox JD, Hunt JA, Compher KM, Fierke CA, Christianson DW. Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry. 39: 13687-94. PMID 11076507 DOI: 10.1021/Bi001649J |
0.393 |
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| 2000 |
Spence RA, Hightower KE, Terry KL, Beese LS, Fierke CA, Casey PJ. Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. Biochemistry. 39: 13651-9. PMID 11076503 DOI: 10.1021/Bi001084R |
0.463 |
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| 2000 |
Saderholm MJ, Hightower KE, Fierke CA. Role of metals in the reaction catalyzed by protein farnesyltransferase. Biochemistry. 39: 12398-405. PMID 11015220 DOI: 10.1021/Bi0011781 |
0.828 |
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| 2000 |
Kurz JC, Fierke CA. Ribonuclease P: a ribonucleoprotein enzyme. Current Opinion in Chemical Biology. 4: 553-8. PMID 11006544 DOI: 10.1016/S1367-5931(00)00131-9 |
0.77 |
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| 2000 |
McCall KA, Fierke CA. Colorimetric and fluorimetric assays to quantitate micromolar concentrations of transition metals. Analytical Biochemistry. 284: 307-15. PMID 10964414 DOI: 10.1006/Abio.2000.4706 |
0.356 |
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| 2000 |
Ziehler WA, Day JJ, Fierke CA, Engelke DR. Effects of 5' leader and 3' trailer structures on pre-tRNA processing by nuclear RNase P. Biochemistry. 39: 9909-16. PMID 10933810 DOI: 10.1021/Bi000603N |
0.612 |
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| 2000 |
Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A. Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II. Organic Letters. 2: 1189-92. PMID 10810704 DOI: 10.1021/Ol005608R |
0.348 |
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| 2000 |
McCall KA, Huang C, Fierke CA. Function and mechanism of zinc metalloenzymes. The Journal of Nutrition. 130: 1437S-46S. PMID 10801957 DOI: 10.1093/Jn/130.5.1437S |
0.455 |
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| 2000 |
Burton RE, Hunt JA, Fierke CA, Oas TG. Novel disulfide engineering in human carbonic anhydrase II using the PAIRWISE side-chain geometry database. Protein Science : a Publication of the Protein Society. 9: 776-85. PMID 10794421 DOI: 10.1110/Ps.9.4.776 |
0.358 |
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| 2000 |
Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs. The Journal of Biological Chemistry. 275: 11002-9. PMID 10753902 DOI: 10.1074/Jbc.275.15.11002 |
0.747 |
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| 2000 |
Thompson RB, Whetsell WO, Maliwal BP, Fierke CA, Frederickson CJ. Fluorescence microscopy of stimulated Zn(II) release from organotypic cultures of mammalian hippocampus using a carbonic anhydrase-based biosensor system. Journal of Neuroscience Methods. 96: 35-45. PMID 10704669 DOI: 10.1016/S0165-0270(99)00183-1 |
0.329 |
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| 2000 |
Huang C, Hightower KE, Fierke CA. Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state. Biochemistry. 39: 2593-602. PMID 10704208 DOI: 10.1021/Bi992356X |
0.429 |
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| 2000 |
Kim CY, Chang JS, Doyon JB, Baird TT, Fierke CA, Jain A, Christianson DW. Contribution of fluorine to protein - Ligand affinity in the binding of fluoroaromatic inhibitors to carbonic anhydrase II Journal of the American Chemical Society. 122: 12125-12134. DOI: 10.1021/Ja002627N |
0.345 |
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| 1999 |
Alber BE, Colangelo CM, Dong J, Stålhandske CM, Baird TT, Tu C, Fierke CA, Silverman DN, Scott RA, Ferry JG. Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarchaeon Methanosarcina thermophila. Biochemistry. 38: 13119-28. PMID 10529183 DOI: 10.1021/Bi9828876 |
0.305 |
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| 1999 |
Hunt JA, Ahmed M, Fierke CA. Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues. Biochemistry. 38: 9054-62. PMID 10413479 DOI: 10.1021/Bi9900166 |
0.441 |
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| 1999 |
Hightower KE, Fierke CA. Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase. Current Opinion in Chemical Biology. 3: 176-81. PMID 10226042 DOI: 10.1016/S1367-5931(99)80030-1 |
0.374 |
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| 1999 |
Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K, Young K, Su LH, Fierke CA, Jackman JE, Raetz CR, Coleman J, Tomoyasu T, Matsuzawa H. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Molecular Microbiology. 31: 833-44. PMID 10048027 DOI: 10.1046/J.1365-2958.1999.01221.X |
0.731 |
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| 1999 |
Jackman JE, Raetz CR, Fierke CA. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme. Biochemistry. 38: 1902-11. PMID 10026271 DOI: 10.1021/Bi982339S |
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| 1999 |
Thompson RB, Maliwal BP, Fierke CA. Selectivity and sensitivity of fluorescence lifetime-based metal ion biosensing using a carbonic anhydrase transducer. Analytical Biochemistry. 267: 185-95. PMID 9918670 DOI: 10.1006/Abio.1998.2991 |
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| 1999 |
Thompson RB, Zeng H, Loetz M, McCall K, Fierke CA. Improved response of a fluorescence-based metal ion biosensor using engineered carbonic anhydrase variants Proceedings of Spie. 3858: 161-166. DOI: 10.1117/12.372913 |
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| 1998 |
Thompson RB, Maliwal BP, Fierke CA. Expanded dynamic range of free zinc ion determination by fluorescence anisotropy. Analytical Chemistry. 70: 1749-54. PMID 21651269 DOI: 10.1021/Ac971199+ |
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|
| 1998 |
Niranjanakumari S, Stams T, Crary SM, Christianson DW, Fierke CA. Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA. Proceedings of the National Academy of Sciences of the United States of America. 95: 15212-7. PMID 9860948 DOI: 10.1073/Pnas.95.26.15212 |
0.821 |
|
| 1998 |
Thompson RB, Maliwal BP, Feliccia VL, Fierke CA, McCall K. Determination of picomolar concentrations of metal ions using fluorescence anisotropy: biosensing with a "reagentless" enzyme transducer. Analytical Chemistry. 70: 4717-23. PMID 9844569 DOI: 10.1021/Ac980864R |
0.389 |
|
| 1998 |
Hightower KE, Huang CC, Casey PJ, Fierke CA. H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. Biochemistry. 37: 15555-62. PMID 9799520 DOI: 10.1021/Bi981525V |
0.434 |
|
| 1998 |
Loria A, Niranjanakumari S, Fierke CA, Pan T. Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme. Biochemistry. 37: 15466-73. PMID 9799509 DOI: 10.1021/Bi9816507 |
0.409 |
|
| 1998 |
Crary SM, Niranjanakumari S, Fierke CA. The protein component of Bacillus subtilis ribonuclease P increases catalytic efficiency by enhancing interactions with the 5' leader sequence of pre-tRNAAsp. Biochemistry. 37: 9409-16. PMID 9649323 DOI: 10.1021/Bi980613C |
0.823 |
|
| 1998 |
Niranjanakumari S, Kurz JC, Fierke CA. Expression, purification and characterization of the recombinant ribonuclease P protein component from Bacillus subtilis. Nucleic Acids Research. 26: 3090-6. PMID 9628904 DOI: 10.1093/Nar/26.13.3090 |
0.775 |
|
| 1998 |
Stams T, Niranjanakumari S, Fierke CA, Christianson DW. Ribonuclease P protein structure: evolutionary origins in the translational apparatus. Science (New York, N.Y.). 280: 752-5. PMID 9563955 DOI: 10.1126/Science.280.5364.752 |
0.418 |
|
| 1998 |
Kurz JC, Niranjanakumari S, Fierke CA. Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNAAsp. Biochemistry. 37: 2393-400. PMID 9485387 DOI: 10.1021/Bi972530M |
0.788 |
|
| 1998 |
Jackman JE, Raetz CRH, Fierke CA. A single zinc is required for UDP-3-O-Acyl-glcnac deacetylase activity Faseb Journal. 12: A1427. |
0.608 |
|
| 1997 |
Lesburg CA, Huang C, Christianson DW, Fierke CA. Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry. 36: 15780-91. PMID 9398308 DOI: 10.1021/Bi971296X |
0.406 |
|
| 1997 |
Hunt JA, Fierke CA. Selection of carbonic anhydrase variants displayed on phage. Aromatic residues in zinc binding site enhance metal affinity and equilibration kinetics. The Journal of Biological Chemistry. 272: 20364-72. PMID 9252341 DOI: 10.1074/Jbc.272.33.20364 |
0.421 |
|
| 1997 |
Wuebbens MW, Roush ED, Decastro CM, Fierke CA. Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. Biochemistry. 36: 4327-36. PMID 9100029 DOI: 10.1021/Bi9627424 |
0.355 |
|
| 1997 |
Huang CC, Casey PJ, Fierke CA. Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. The Journal of Biological Chemistry. 272: 20-3. PMID 8995218 DOI: 10.1074/Jbc.272.1.20 |
0.397 |
|
| 1997 |
Fierke CA, Crarv SM, Kurz JC, Niranjanakumari S. Ribonuclease P: Function of magnesium ions and protein subunit Faseb Journal. 11: A852. |
0.732 |
|
| 1996 |
Thompson RB, Ge Z, Patchan MW, Fierke CA. Performance enhancement of fluorescence energy transfer-based biosensors by site-directed mutagenesis of the transducer. Journal of Biomedical Optics. 1: 131-7. PMID 23014654 DOI: 10.1117/12.227108 |
0.374 |
|
| 1996 |
Venters RA, Farmer BT, Fierke CA, Spicer LD. Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. Journal of Molecular Biology. 264: 1101-16. PMID 9000633 DOI: 10.1006/Jmbi.1996.0699 |
0.316 |
|
| 1996 |
Jackman JE, Merz KM, Fierke CA. Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer. Biochemistry. 35: 16421-8. PMID 8987973 DOI: 10.1021/Bi961786+ |
0.658 |
|
| 1996 |
Beebe JA, Kurz JC, Fierke CA. Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNAAsp. Biochemistry. 35: 10493-505. PMID 8756706 DOI: 10.1021/Bi960870M |
0.772 |
|
| 1996 |
Huang CC, Lesburg CA, Kiefer LL, Fierke CA, Christianson DW. Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry. 35: 3439-46. PMID 8639494 DOI: 10.1021/Bi9526692 |
0.413 |
|
| 1996 |
Christianson DW, Fierke CA. Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design Accounts of Chemical Research. 29: 331-339. DOI: 10.1021/Ar9501232 |
0.307 |
|
| 1996 |
Thompson RB, Ge Z, Patchan M, Huang CC, Fierke CA. Fiber optic biosensor for Co(II) and Cu(II) based on fluorescence energy transfer with an enzyme transducer Biosensors and Bioelectronics. 11: 557-564. DOI: 10.1016/0956-5663(96)83291-X |
0.378 |
|
| 1995 |
Fierke CA, Hammes GG. Transient kinetic approaches to enzyme mechanisms. Methods in Enzymology. 249: 3-37. PMID 7791616 DOI: 10.1016/0076-6879(95)49029-9 |
0.354 |
|
| 1995 |
Ippolito JA, Baird TT, McGee SA, Christianson DW, Fierke CA. Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proceedings of the National Academy of Sciences of the United States of America. 92: 5017-21. PMID 7761440 DOI: 10.1073/Pnas.92.11.5017 |
0.422 |
|
| 1995 |
Nair SK, Krebs JF, Christianson DW, Fierke CA. Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. Biochemistry. 34: 3981-9. PMID 7696263 DOI: 10.1021/Bi00012A016 |
0.381 |
|
| 1995 |
Whitty A, Fierke CA, Jencks WP. Role of binding energy with coenzyme A in catalysis by 3-oxoacid coenzyme A transferase. Biochemistry. 34: 11678-89. PMID 7547900 DOI: 10.1021/Bi00037A005 |
0.712 |
|
| 1995 |
Kiefer LL, Paterno SA, Fierke CA. Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency Journal of the American Chemical Society. 117: 6831-6837. DOI: 10.1021/Ja00131A004 |
0.322 |
|
| 1994 |
Kiefer LL, Fierke CA. Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites Biochemistry. 33: 15233-15240. PMID 7803385 DOI: 10.1021/Bi00255A003 |
0.405 |
|
| 1994 |
Beebe JA, Fierke CA. A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P. Biochemistry. 33: 10294-304. PMID 7520753 DOI: 10.1021/Bi00200A009 |
0.396 |
|
| 1993 |
Krebs JF, Rana F, Dluhy RA, Fierke CA. Kinetic and spectroscopic studies of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II Biochemistry. 32: 4496-4505. PMID 8485128 DOI: 10.1021/Bi00068A004 |
0.38 |
|
| 1993 |
Alexander RS, Kiefer LL, Fierke CA, Christianson DW. Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Biochemistry. 32: 1510-8. PMID 8431430 DOI: 10.1021/Bi00057A015 |
0.378 |
|
| 1993 |
Kiefer LL, Krebs JF, Paterno SA, Fierke CA. Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II Biochemistry. 32: 9896-9900. PMID 8399158 DOI: 10.1021/Bi00089A004 |
0.405 |
|
| 1993 |
Kiefer LL, Ippolito JA, Fierke CA, Christianson DW. Redesigning The Zinc-Binding Site Of Human Carbonic Anhydrase-Ii - Structure Of A His2Asp-Zn2+ Metal Coordination Polyhedron. Journal of the American Chemical Society. 115: 12581-12582. DOI: 10.1021/Ja00079A046 |
0.355 |
|
| 1992 |
Roush ED, Fierke CA. Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma Biochemistry. 31: 12536-12542. PMID 1463741 DOI: 10.1021/Bi00164A034 |
0.315 |
|
| 1991 |
Nair SK, Calderone TL, Christianson DW, Fierke CA. Altering the mouth of a hydrophobic pocket: Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121 Journal of Biological Chemistry. 266: 17320-17325. PMID 1910042 DOI: 10.2210/Pdb12Ca/Pdb |
0.394 |
|
| 1991 |
Krebs JF, Fierke CA, Alexander RS, Christianson DW. Conformational mobility of His-64 in the Thr-200 → ser mutant of human carbonic anhydrase II Biochemistry. 30: 9153-9160. PMID 1909891 DOI: 10.1021/Bi00102A005 |
0.362 |
|
| 1991 |
Adams JA, Fierke CA, Benkovic SJ. The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli. Biochemistry. 30: 11046-54. PMID 1834173 DOI: 10.1021/Bi00110A006 |
0.5 |
|
| 1991 |
Fierke CA. Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II Biochemistry. 30: 11054-11063. PMID 1657158 DOI: 10.1021/Bi00110A007 |
0.378 |
|
| 1989 |
Andrews J, Fierke CA, Birdsall B, Ostler G, Feeney J, Roberts GC, Benkovic SJ. A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei. Biochemistry. 28: 5743-50. PMID 2505841 DOI: 10.1021/Bi00440A007 |
0.513 |
|
| 1989 |
Fierke CA, Benkovic SJ. Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding. Biochemistry. 28: 478-86. PMID 2496745 DOI: 10.1021/Bi00428A011 |
0.536 |
|
| 1989 |
Benkovic SJ, Adams JA, Fierke CA, Naylor AM. Insights into Enzymic Catalysis from Studies on Dihydrofolate Reductases Pteridines. 1: 37-43. DOI: 10.1515/Pteridines.1989.1.1.37 |
0.523 |
|
| 1988 |
Benkovic SJ, Fierke CA, Naylor AM. Insights into enzyme function from studies on mutants of dihydrofolate reductase. Science (New York, N.Y.). 239: 1105-10. PMID 3125607 DOI: 10.1126/Science.3125607 |
0.554 |
|
| 1987 |
Fierke CA, Kuchta RD, Johnson KA, Benkovic SJ. Implications for enzymic catalysis from free-energy reaction coordinate profiles. Cold Spring Harbor Symposia On Quantitative Biology. 52: 631-8. PMID 3331348 DOI: 10.1101/Sqb.1987.052.01.072 |
0.478 |
|
| 1987 |
Fierke CA, Johnson KA, Benkovic SJ. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry. 26: 4085-92. PMID 3307916 DOI: 10.1021/Bi00387A052 |
0.474 |
|
| 1987 |
Taira K, Chen J, Fierke CA, Benkovic SJ. Protein Engineering of Dihydrofolate Reductase. pH Dependency of Phe-31 Mutants Bulletin of the Chemical Society of Japan. 60: 3025-3030. DOI: 10.1246/Bcsj.60.3025 |
0.459 |
|
| 1987 |
Taira K, Fierke CA, Chen J, Johnson KA, Benkovic SJ. On interpreting the inhibition of and catalysis by dihydrofolate reductase Trends in Biochemical Sciences. 12: 275-278. DOI: 10.1016/0968-0004(87)90134-4 |
0.542 |
|
| 1986 |
Mayer RJ, Chen JT, Taira K, Fierke CA, Benkovic SJ. Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 83: 7718-20. PMID 3463995 DOI: 10.1073/Pnas.83.20.7718 |
0.532 |
|
| 1986 |
Fierke CA, Jencks WP. Two functional domains of coenzyme A activate catalysis by coenzyme A transferase. Pantetheine and adenosine 3'-phosphate 5'-diphosphate. The Journal of Biological Chemistry. 261: 7603-6. PMID 3458707 |
0.515 |
|
| 1985 |
Chen JT, Mayer RJ, Fierke CA, Benkovic SJ. Site-specific mutagenesis of dihydrofolate reductase from Escherichia coli. Journal of Cellular Biochemistry. 29: 73-82. PMID 3905833 DOI: 10.1002/Jcb.240290203 |
0.531 |
|
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