| Year |
Citation |
Score |
| 2024 |
Eaton SA, Christianson DW. Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry. PMID 38420671 DOI: 10.1021/acs.biochem.3c00681 |
0.318 |
|
| 2024 |
Gaynes MN, Ronnebaum TA, Schultz K, Faylo JL, Marmorstein R, Christianson DW. Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation. Journal of Structural Biology. 216: 108060. PMID 38184156 DOI: 10.1016/j.jsb.2023.108060 |
0.807 |
|
| 2023 |
Watson PR, Stollmaier JG, Christianson DW. Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism. The Journal of Biological Chemistry. 299: 105228. PMID 37703993 DOI: 10.1016/j.jbc.2023.105228 |
0.313 |
|
| 2023 |
Watson PR, Christianson DW. Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen . Biochemistry. PMID 37624144 DOI: 10.1021/acs.biochem.3c00288 |
0.412 |
|
| 2023 |
Watson PR, Stollmaier JG, Christianson DW. Crystal Structure of Histone Deacetylase 6 Complexed with ( )-Lipoic Acid, an Essential Cofactor in Central Carbon Metabolism. Biorxiv : the Preprint Server For Biology. PMID 37609266 DOI: 10.1101/2023.08.08.552419 |
0.339 |
|
| 2023 |
Watson PR, Gupta S, Hosseinzadeh P, Brown BP, Baker D, Christianson DW. Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6. Acs Chemical Biology. PMID 37027789 DOI: 10.1021/acschembio.3c00113 |
0.322 |
|
| 2022 |
Eaton SA, Ronnebaum TA, Roose BW, Christianson DW. Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase -Dimethylallyl-l-tryptophan Synthase from . Biochemistry. 61: 2025-2035. PMID 36084241 DOI: 10.1021/acs.biochem.2c00350 |
0.806 |
|
| 2022 |
Tararina MA, Yee DA, Tang Y, Christianson DW. Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis. Biochemistry. 61: 2014-2024. PMID 36037799 DOI: 10.1021/acs.biochem.2c00335 |
0.553 |
|
| 2021 |
Ronnebaum TA, Eaton SA, Brackhahn EAE, Christianson DW. Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase. Biochemistry. 60: 3162-3172. PMID 34609847 DOI: 10.1021/acs.biochem.1c00600 |
0.808 |
|
| 2021 |
Faylo JL, Ronnebaum TA, Christianson DW. Assembly-Line Catalysis in Bifunctional Terpene Synthases. Accounts of Chemical Research. PMID 34254507 DOI: 10.1021/acs.accounts.1c00296 |
0.792 |
|
| 2021 |
Olaoye OO, Watson PR, Nawar N, Geletu M, Sedighi A, Bukhari S, Raouf YS, Manaswiyoungkul P, Erdogan F, Abdeldayem A, Cabral AD, Hassan MM, Toutah K, Shouksmith AE, Gawel JM, ... ... Christianson DW, et al. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of Medicinal Chemistry. PMID 33576627 DOI: 10.1021/acs.jmedchem.0c01922 |
0.335 |
|
| 2021 |
Herbst-Gervasoni CJ, Christianson DW. X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry. PMID 33449614 DOI: 10.1021/acs.biochem.0c00936 |
0.389 |
|
| 2020 |
Ronnebaum TA, Gardner SM, Christianson DW. An Aromatic Cluster in the Active Site of -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry. PMID 33270439 DOI: 10.1021/acs.biochem.0c00876 |
0.816 |
|
| 2020 |
Osko JD, Christianson DW. Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallographica. Section F, Structural Biology Communications. 76: 428-437. PMID 32880591 DOI: 10.1107/S2053230X20010250 |
0.359 |
|
| 2020 |
Reßing N, S Ouml Nnichsen M, Osko J, Schöler A, Schliehe-Diecks J, Skerhut AJ, Borkhardt A, Hauer J, Kassack MU, Christianson DW, Bhatia S, Hansen FK. Multicomponent synthesis, binding mode and structure-activity relationships of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groups. Journal of Medicinal Chemistry. PMID 32803970 DOI: 10.1021/Acs.Jmedchem.9B01888 |
0.397 |
|
| 2020 |
He H, Bian G, Herbst-Gervasoni CJ, Mori T, Shinsky SA, Hou A, Mu X, Huang M, Cheng S, Deng Z, Christianson DW, Abe I, Liu T. Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature Communications. 11: 3958. PMID 32769971 DOI: 10.1038/S41467-020-17642-2 |
0.376 |
|
| 2020 |
Herbst-Gervasoni CJ, Steimbach RR, Morgen M, Miller AK, Christianson DW. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chemical Biology. PMID 32659072 DOI: 10.1021/Acschembio.0C00362 |
0.462 |
|
| 2020 |
Blank PN, Barnett AA, Ronnebaum TA, Alderfer KE, Gillott BN, Christianson DW, Himmelberger JA. Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota. Acta Crystallographica Section D-Biological Crystallography. 76: 542-557. PMID 32496216 DOI: 10.1107/S2059798320004878 |
0.803 |
|
| 2020 |
Miller AK, Morgen M, Steimbach RR, Géraldy M, Hellweg L, Sehr P, Ridinger J, Witt O, Oehme I, Herbst-Gervasoni CJ, Osko JD, Porter NJ, Christianson DW, Gunkel N. Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem. PMID 32348628 DOI: 10.1002/Cmdc.202000149 |
0.343 |
|
| 2020 |
Osko JD, Christianson DW. Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6. Bioorganic & Medicinal Chemistry Letters. 127023. PMID 32067866 DOI: 10.1016/J.Bmcl.2020.127023 |
0.431 |
|
| 2020 |
Ronnebaum TA, Gupta K, Christianson DW. Higher-Order Oligomerization of a Chimeric αβγ Bifunctional Diterpene Synthase with Prenyltransferase and Class II Cyclase Activities is Concentration-Dependent. Journal of Structural Biology. 107463. PMID 31978464 DOI: 10.1016/J.Jsb.2020.107463 |
0.791 |
|
| 2019 |
Osko JD, Porter NJ, Reddy PAN, Xiao YC, Rokka J, Jung M, Hooker JM, Salvino JM, Christianson DW. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. Journal of Medicinal Chemistry. PMID 31793776 DOI: 10.1021/Acs.Jmedchem.9B01540 |
0.451 |
|
| 2019 |
Osko JD, Christianson DW. Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry. PMID 31755702 DOI: 10.1021/Acs.Biochem.9B00934 |
0.317 |
|
| 2019 |
Herbst-Gervasoni CJ, Christianson DW. Binding of N8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry. PMID 31746596 DOI: 10.1021/Acs.Biochem.9B00906 |
0.474 |
|
| 2019 |
Welker Leng K, Castaneda CA, Decroos C, Islam B, Haider S, Christianson DW, Fierke CA. Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant. Biochemistry. PMID 31633931 DOI: 10.1021/Acs.Biochem.9B00653 |
0.462 |
|
| 2019 |
Porter NJ, Christianson DW. Preparation of a new construct of human histone deacetylase 8 for the crystallization of enzyme-inhibitor complexes. Methods in Enzymology. 626: 561-585. PMID 31606091 DOI: 10.1016/Bs.Mie.2019.06.029 |
0.431 |
|
| 2019 |
Osko JD, Christianson DW. Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes. Methods in Enzymology. 626: 447-474. PMID 31606087 DOI: 10.1016/Bs.Mie.2019.06.028 |
0.385 |
|
| 2019 |
Osko JD, Roose BW, Shinsky SA, Christianson DW. Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth Halophile . Biochemistry. PMID 31436969 DOI: 10.1021/Acs.Biochem.9B00582 |
0.494 |
|
| 2019 |
Roose BW, Christianson DW. Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD. Biochemistry. PMID 31251043 DOI: 10.2210/Pdb6Os6/Pdb |
0.427 |
|
| 2019 |
Blank PN, Barrow GH, Christianson DW. Crystal structure of F95Q epi-isozizaene synthase, an engineered sesquiterpene cyclase that generates biofuel precursors β- and γ-curcumene. Journal of Structural Biology. PMID 31152775 DOI: 10.1016/J.Jsb.2019.05.011 |
0.427 |
|
| 2019 |
Blank PN, Shinsky SA, Christianson DW. Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product. Acs Chemical Biology. PMID 30977996 DOI: 10.1021/Acschembio.9B00218 |
0.51 |
|
| 2019 |
Porter NJ, Christianson DW. Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases. Current Opinion in Structural Biology. 59: 9-18. PMID 30743180 DOI: 10.1016/J.Sbi.2019.01.004 |
0.341 |
|
| 2019 |
Vögerl K, Ong N, Senger J, Herp D, Schmidtkunz K, Marek M, Müller M, Bartel K, Shaik TB, Porter NJ, Robaa D, Christianson DW, Romier C, Sippl W, Jung M, et al. Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 (HDAC6) Inhibitors. Journal of Medicinal Chemistry. PMID 30645113 DOI: 10.1021/Acs.Jmedchem.8B01090 |
0.387 |
|
| 2018 |
Porter NJ, Shen S, Barinka C, Kozikowski AP, Christianson DW. Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. Acs Medicinal Chemistry Letters. 9: 1301-1305. PMID 30613344 DOI: 10.2210/Pdb6Mr5/Pdb |
0.405 |
|
| 2018 |
Christianson DW. Correction to Structural and Chemical Biology of Terpenoid Cyclases. Chemical Reviews. PMID 30540443 DOI: 10.1021/Acs.Chemrev.8B00682 |
0.317 |
|
| 2018 |
Bhatia S, Krieger V, Groll M, Osko J, Reßing N, Ahlert H, Borkhardt A, Kurz T, Christianson DW, Hauer J, Hansen FK. Discovery of the first-in-class dual histone deacetylase-proteasome inhibitor. Journal of Medicinal Chemistry. PMID 30365892 DOI: 10.2210/Pdb6H39/Pdb |
0.375 |
|
| 2018 |
Blank PN, Pemberton TA, Chow JY, Poulter CD, Christianson DW. Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene. Biochemistry. PMID 30346736 DOI: 10.1021/Acs.Biochem.8B00899 |
0.46 |
|
| 2018 |
Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW. Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. Journal of Medicinal Chemistry. PMID 30118224 DOI: 10.1021/Acs.Jmedchem.8B01013 |
0.424 |
|
| 2018 |
Mackwitz MKW, Hamacher A, Osko JD, Held J, Schöler A, Christianson DW, Kassack MU, Hansen FK. Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors. Organic Letters. PMID 29790770 DOI: 10.1021/Acs.Orglett.8B01118 |
0.391 |
|
| 2018 |
Porter NJ, Wagner FF, Christianson DW. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. PMID 29775292 DOI: 10.1021/Acs.Biochem.8B00367 |
0.39 |
|
| 2018 |
Shinsky S, Christianson DW. Polyamine Deacetylase Structure and Catalysis: Prokaryotic Acetylpolyamine Amidohydrolase and Eukaryotic HDAC10. Biochemistry. PMID 29533602 DOI: 10.1021/Acs.Biochem.8B00079 |
0.463 |
|
| 2017 |
Porter NJ, Mahendran A, Breslow R, Christianson DW. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203661 DOI: 10.1073/Pnas.1718823114 |
0.451 |
|
| 2017 |
Blank PN, Harris GG, Chou WKW, Duan L, Cane DE, Christianson DW. Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry. PMID 28967743 DOI: 10.1021/Acs.Biochem.7B00895 |
0.424 |
|
| 2017 |
Porter NJ, Christianson DW. Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8. Acs Chemical Biology. PMID 28846375 DOI: 10.1021/Acschembio.7B00330 |
0.444 |
|
| 2017 |
Christianson DW. Structural and Chemical Biology of Terpenoid Cyclases. Chemical Reviews. PMID 28841019 DOI: 10.1021/Acs.Chemrev.7B00287 |
0.449 |
|
| 2017 |
Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher Iii FJ, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, ... Christianson DW, et al. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nature Cell Biology. PMID 28737768 DOI: 10.1038/Ncb3582 |
0.546 |
|
| 2017 |
Hai Y, Shinsky SA, Porter NJ, Christianson DW. Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nature Communications. 8: 15368. PMID 28516954 DOI: 10.1038/Ncomms15368 |
0.631 |
|
| 2017 |
Pemberton TA, Chen M, Harris GG, Chou WK, Duan L, Köksal M, Genshaft AS, Cane DE, Christianson DW. Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry. PMID 28362483 DOI: 10.1021/Acs.Biochem.7B00137 |
0.316 |
|
| 2016 |
Porter NJ, Christianson NH, Decroos C, Christianson DW. Structural and Functional Influence of the Glycine-Rich Loop G(302)GGGY on the Catalytic Tyrosine of Histone Deacetylase 8. Biochemistry. 55: 6718-6729. PMID 27933794 DOI: 10.1021/Acs.Biochem.6B01014 |
0.387 |
|
| 2016 |
Christianson DW, Scrutton NS. Editorial overview: Catalysis and regulation: enzyme structure, mechanism, and biosynthetic pathways. Current Opinion in Structural Biology. PMID 27646478 DOI: 10.1016/J.Sbi.2016.09.005 |
0.372 |
|
| 2016 |
Deardorff MA, Porter NA, Christianson DW. Structural Aspects of HDAC8 Mechanism and Dysfunction in Cornelia de Lange Syndrome Spectrum Disorders. Protein Science : a Publication of the Protein Society. PMID 27576763 DOI: 10.1002/Pro.3030 |
0.346 |
|
| 2016 |
Hai Y, Christianson DW. Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nature Chemical Biology. PMID 27454933 DOI: 10.1038/Nchembio.2134 |
0.62 |
|
| 2016 |
Chen M, Harris GG, Pemberton TA, Christianson DW. Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis. Current Opinion in Structural Biology. 41: 27-37. PMID 27285057 DOI: 10.1016/J.Sbi.2016.05.010 |
0.391 |
|
| 2016 |
Chen M, Chou WK, Al-Lami N, Faraldos JA, Allemann RK, Cane DE, Christianson DW. Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry. PMID 27172425 DOI: 10.1021/Acs.Biochem.6B00343 |
0.386 |
|
| 2016 |
Pemberton TA, Christianson DW. General base-general acid catalysis by terpenoid cyclases. The Journal of Antibiotics. PMID 27072285 DOI: 10.1038/Ja.2016.39 |
0.408 |
|
| 2016 |
Hai Y, Christianson DW. Crystal structures of Leishmania mexicana arginase complexed with α,α-disubstituted boronic amino-acid inhibitors. Acta Crystallographica. Section F, Structural Biology Communications. 72: 300-6. PMID 27050264 DOI: 10.1107/S2053230X16003630 |
0.657 |
|
| 2016 |
Grundy DJ, Chen M, González V, Leoni S, Miller DJ, Christianson DW, Allemann RK. Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture. Biochemistry. 55: 2112-21. PMID 26998816 DOI: 10.1021/Acs.Biochem.6B00115 |
0.441 |
|
| 2016 |
Gantt SM, Decroos C, Lee MS, Gullett LE, Bowman CM, Christianson DW, Fierke CA. General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry. PMID 26806311 DOI: 10.1021/Acs.Biochem.5B01327 |
0.44 |
|
| 2016 |
Chen M, Chou WK, Toyomasu T, Cane DE, Christianson DW. Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. Acs Chemical Biology. PMID 26734760 DOI: 10.1021/Acschembio.5B00960 |
0.47 |
|
| 2015 |
Harris GG, Lombardi PM, Pemberton TA, Matsui T, Weiss TM, Cole KE, Köksal M, Murphy FV, Vedula LS, Chou WK, Cane DE, Christianson DW. Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry. PMID 26598179 DOI: 10.1021/Acs.Biochem.5B01143 |
0.789 |
|
| 2015 |
Decroos C, Christianson DW. Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry. 54: 4692-703. PMID 26200446 DOI: 10.1021/Acs.Biochem.5B00536 |
0.486 |
|
| 2015 |
Decroos C, Clausen DJ, Haines BE, Wiest O, Williams RM, Christianson DW. Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8. Biochemistry. 54: 2126-35. PMID 25793284 DOI: 10.1021/Acs.Biochem.5B00010 |
0.517 |
|
| 2015 |
Hai Y, Kerkhoven EJ, Barrett MP, Christianson DW. Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster. Biochemistry. 54: 458-71. PMID 25536859 DOI: 10.1021/Bi501366A |
0.683 |
|
| 2014 |
Decroos C, Bowman CM, Moser JA, Christianson KE, Deardorff MA, Christianson DW. Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders. Acs Chemical Biology. 9: 2157-64. PMID 25075551 DOI: 10.1021/Cb5003762 |
0.362 |
|
| 2014 |
Hai Y, Edwards JE, Van Zandt MC, Hoffmann KF, Christianson DW. Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis. Biochemistry. 53: 4671-84. PMID 25007099 DOI: 10.1021/Bi5004519 |
0.691 |
|
| 2014 |
Li R, Chou WK, Himmelberger JA, Litwin KM, Harris GG, Cane DE, Christianson DW. Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase. Biochemistry. 53: 1155-68. PMID 24517311 DOI: 10.1021/Bi401643U |
0.446 |
|
| 2014 |
Köksal M, Potter K, Peters RJ, Christianson DW. 1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis. Biochimica Et Biophysica Acta. 1840: 184-90. PMID 24036329 DOI: 10.1016/J.Bbagen.2013.09.004 |
0.429 |
|
| 2013 |
Hai Y, Dugery RJ, Healy D, Christianson DW. Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme. Biochemistry. 52: 9294-309. PMID 24261485 DOI: 10.1021/Bi401352H |
0.671 |
|
| 2013 |
Chen M, Al-lami N, Janvier M, D'Antonio EL, Faraldos JA, Cane DE, Allemann RK, Christianson DW. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry. 52: 5441-53. PMID 23905850 DOI: 10.1021/Bi400691V |
0.504 |
|
| 2013 |
Köksal M, Chou WK, Cane DE, Christianson DW. Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase. Biochemistry. 52: 5247-55. PMID 23844678 DOI: 10.1021/Bi400797C |
0.501 |
|
| 2013 |
Decroos C, Bowman CM, Christianson DW. Synthesis and evaluation of Nâ¸-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase. Bioorganic & Medicinal Chemistry. 21: 4530-40. PMID 23790721 DOI: 10.1016/J.Bmc.2013.05.045 |
0.449 |
|
| 2013 |
D'Antonio EL, Ullman B, Roberts SC, Dixit UG, Wilson ME, Hai Y, Christianson DW. Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Archives of Biochemistry and Biophysics. 535: 163-76. PMID 23583962 DOI: 10.1016/J.Abb.2013.03.015 |
0.691 |
|
| 2013 |
Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. Journal of Medicinal Chemistry. 56: 2429-46. PMID 23432095 DOI: 10.1021/Jm3017656 |
0.306 |
|
| 2013 |
Genshaft A, Moser JA, D'Antonio EL, Bowman CM, Christianson DW. Energetically unfavorable amide conformations for N6-acetyllysine side chains in refined protein structures. Proteins. 81: 1051-7. PMID 23401043 DOI: 10.1002/Prot.24262 |
0.384 |
|
| 2012 |
Faraldos JA, Gonzalez V, Li A, Yu F, Köksal M, Christianson DW, Allemann RK. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases. Journal of the American Chemical Society. 134: 20844-8. PMID 23214943 DOI: 10.1021/Ja311022S |
0.348 |
|
| 2012 |
D'Antonio EL, Hai Y, Christianson DW. Structure and function of non-native metal clusters in human arginase I. Biochemistry. 51: 8399-409. PMID 23061982 DOI: 10.1021/Bi301145N |
0.653 |
|
| 2012 |
Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, ... ... Christianson DW, et al. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature. 489: 313-7. PMID 22885700 DOI: 10.1038/Nature11316 |
0.769 |
|
| 2012 |
D'Antonio EL, Christianson DW. Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 889-93. PMID 22869115 DOI: 10.1107/S1744309112027820 |
0.411 |
|
| 2012 |
Chen M, Adeniji AO, Twenter BM, Winkler JD, Christianson DW, Penning TM. Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorganic & Medicinal Chemistry Letters. 22: 3492-7. PMID 22507964 DOI: 10.1016/J.Bmcl.2012.03.085 |
0.356 |
|
| 2012 |
Köksal M, Chou WK, Cane DE, Christianson DW. Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate. Biochemistry. 51: 3011-20. PMID 22455514 DOI: 10.1021/Bi201827A |
0.444 |
|
| 2012 |
Köksal M, Chou WK, Cane DE, Christianson DW. Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification. Biochemistry. 51: 3003-10. PMID 22455498 DOI: 10.1021/Bi300109C |
0.461 |
|
| 2012 |
Chen M, Drury JE, Christianson DW, Penning TM. Conversion of human steroid 5β-reductase (AKR1D1) into 3β-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering. The Journal of Biological Chemistry. 287: 16609-22. PMID 22437839 DOI: 10.1074/Jbc.M111.338780 |
0.453 |
|
| 2011 |
Ilies M, Dowling DP, Lombardi PM, Christianson DW. Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorganic & Medicinal Chemistry Letters. 21: 5854-8. PMID 21875805 DOI: 10.1016/J.Bmcl.2011.07.100 |
0.808 |
|
| 2011 |
Lombardi PM, Cole KE, Dowling DP, Christianson DW. Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes. Current Opinion in Structural Biology. 21: 735-43. PMID 21872466 DOI: 10.1016/J.Sbi.2011.08.004 |
0.805 |
|
| 2011 |
D'Antonio EL, Christianson DW. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry. 50: 8018-27. PMID 21870783 DOI: 10.1021/Bi201101T |
0.433 |
|
| 2011 |
Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. Journal of the American Chemical Society. 133: 12474-7. PMID 21790156 DOI: 10.1021/Ja205972N |
0.803 |
|
| 2011 |
Ilies M, Di Costanzo L, Dowling DP, Thorn KJ, Christianson DW. Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design. Journal of Medicinal Chemistry. 54: 5432-43. PMID 21728378 DOI: 10.1021/Jm200443B |
0.666 |
|
| 2011 |
Köksal M, Hu H, Coates RM, Peters RJ, Christianson DW. Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase. Nature Chemical Biology. 7: 431-3. PMID 21602811 DOI: 10.1038/Nchembio.578 |
0.376 |
|
| 2011 |
Lombardi PM, Angell HD, Whittington DA, Flynn EF, Rajashankar KR, Christianson DW. Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases. Biochemistry. 50: 1808-17. PMID 21268586 DOI: 10.1021/Bi101859K |
0.832 |
|
| 2011 |
Cole KE, Gattis SG, Angell HD, Fierke CA, Christianson DW. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 . Biochemistry. 50: 258-65. PMID 21171638 DOI: 10.1021/Bi101622A |
0.761 |
|
| 2011 |
Köksal M, Jin Y, Coates RM, Croteau R, Christianson DW. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature. 469: 116-20. PMID 21160477 DOI: 10.1038/Nature09628 |
0.47 |
|
| 2010 |
Aaron JA, Christianson DW. Trinuclear Metal Clusters in Catalysis by Terpenoid Synthases. Pure and Applied Chemistry. Chimie Pure Et Appliquee. 82: 1585-1597. PMID 21562622 DOI: 10.1351/Pac-Con-09-09-37 |
0.813 |
|
| 2010 |
Köksal M, Zimmer I, Schnitzler JP, Christianson DW. Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission. Journal of Molecular Biology. 402: 363-73. PMID 20624401 DOI: 10.1016/J.Jmb.2010.07.009 |
0.395 |
|
| 2010 |
Dowling DP, Gattis SG, Fierke CA, Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Biochemistry. 49: 5048-56. PMID 20545365 DOI: 10.1021/Bi1005046 |
0.642 |
|
| 2010 |
Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . Biochemistry. 49: 5600-8. PMID 20527960 DOI: 10.1021/Bi100390Z |
0.67 |
|
| 2010 |
Smith AB, Xiong H, Charnley AK, Brenner M, Mesaros EF, Kenesky CS, Di Costanzo L, Christianson DW, Hirschmann R. Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones. Organic Letters. 12: 2994-7. PMID 20518572 DOI: 10.1021/Ol101008Y |
0.364 |
|
| 2010 |
Ilies M, Di Costanzo L, North ML, Scott JA, Christianson DW. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. Journal of Medicinal Chemistry. 53: 4266-76. PMID 20441173 DOI: 10.1021/Jm100306A |
0.35 |
|
| 2010 |
Di Costanzo L, Ilies M, Thorn KJ, Christianson DW. Inhibition of human arginase I by substrate and product analogues. Archives of Biochemistry and Biophysics. 496: 101-8. PMID 20153713 DOI: 10.1016/J.Abb.2010.02.004 |
0.47 |
|
| 2010 |
Aaron JA, Lin X, Cane DE, Christianson DW. Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. Biochemistry. 49: 1787-97. PMID 20131801 DOI: 10.1021/Bi902088Z |
0.832 |
|
| 2009 |
Drury JE, Di Costanzo L, Penning TM, Christianson DW. Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. The Journal of Biological Chemistry. 284: 19786-90. PMID 19515843 DOI: 10.1074/Jbc.C109.016931 |
0.372 |
|
| 2009 |
Gennadios HA, Gonzalez V, Di Costanzo L, Li A, Yu F, Miller DJ, Allemann RK, Christianson DW. Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis. Biochemistry. 48: 6175-83. PMID 19489610 DOI: 10.1021/Bi900483B |
0.816 |
|
| 2009 |
Chambers JM, Hill PA, Aaron JA, Han Z, Christianson DW, Kuzma NN, Dmochowski IJ. Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase. Journal of the American Chemical Society. 131: 563-9. PMID 19140795 DOI: 10.1021/ja806092w |
0.792 |
|
| 2009 |
Shishova EY, Di Costanzo L, Emig FA, Ash DE, Christianson DW. Probing the specificity determinants of amino acid recognition by arginase. Biochemistry. 48: 121-31. PMID 19093830 DOI: 10.1021/Bi801911V |
0.76 |
|
| 2009 |
Di Costanzo L, Penning TM, Christianson DW. Aldo-keto reductases in which the conserved catalytic histidine is substituted. Chemico-Biological Interactions. 178: 127-33. PMID 19028475 DOI: 10.1016/J.Cbi.2008.10.046 |
0.402 |
|
| 2009 |
Di Costanzo L, Drury JE, Christianson DW, Penning TM. Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1). Molecular and Cellular Endocrinology. 301: 191-8. PMID 18848863 DOI: 10.1016/J.Mce.2008.09.013 |
0.404 |
|
| 2008 |
Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 47: 13554-63. PMID 19053282 DOI: 10.1021/Bi801610C |
0.71 |
|
| 2008 |
Zakharian TY, Di Costanzo L, Christianson DW. (S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Journal of the American Chemical Society. 130: 17254-5. PMID 19032027 DOI: 10.1021/Ja807702Q |
0.453 |
|
| 2008 |
Butts CA, Swift J, Kang SG, Di Costanzo L, Christianson DW, Saven JG, Dmochowski IJ. Directing noble metal ion chemistry within a designed ferritin protein. Biochemistry. 47: 12729-39. PMID 18991401 DOI: 10.1021/Bi8016735 |
0.364 |
|
| 2008 |
Zakharian TY, Di Costanzo L, Christianson DW. Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I. Organic & Biomolecular Chemistry. 6: 3240-3. PMID 18802628 DOI: 10.1039/B811797G |
0.463 |
|
| 2008 |
Aaron JA, Chambers JM, Jude KM, Di Costanzo L, Dmochowski IJ, Christianson DW. Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II. Journal of the American Chemical Society. 130: 6942-3. PMID 18461940 DOI: 10.1021/Ja802214X |
0.796 |
|
| 2008 |
Di Costanzo L, Drury JE, Penning TM, Christianson DW. Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis. The Journal of Biological Chemistry. 283: 16830-9. PMID 18407998 DOI: 10.1074/Jbc.M801778200 |
0.412 |
|
| 2008 |
Shishova EY, Yu F, Miller DJ, Faraldos JA, Zhao Y, Coates RM, Allemann RK, Cane DE, Christianson DW. X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. The Journal of Biological Chemistry. 283: 15431-9. PMID 18385128 DOI: 10.1074/Jbc.M800659200 |
0.78 |
|
| 2008 |
Dowling DP, Di Costanzo L, Gennadios HA, Christianson DW. Evolution of the arginase fold and functional diversity. Cellular and Molecular Life Sciences : Cmls. 65: 2039-55. PMID 18360740 DOI: 10.1007/S00018-008-7554-Z |
0.79 |
|
| 2008 |
Christianson DW. Unearthing the roots of the terpenome. Current Opinion in Chemical Biology. 12: 141-50. PMID 18249199 DOI: 10.1016/J.Cbpa.2007.12.008 |
0.411 |
|
| 2008 |
Vedula LS, Jiang J, Zakharian T, Cane DE, Christianson DW. Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif. Archives of Biochemistry and Biophysics. 469: 184-94. PMID 17996718 DOI: 10.1016/J.Abb.2007.10.015 |
0.824 |
|
| 2007 |
Santhanam L, Lim HK, Lim HK, Miriel V, Brown T, Patel M, Balanson S, Ryoo S, Anderson M, Irani K, Khanday F, Di Costanzo L, Nyhan D, Hare JM, Christianson DW, et al. Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction. Circulation Research. 101: 692-702. PMID 17704205 DOI: 10.1161/Circresaha.107.157727 |
0.33 |
|
| 2007 |
Vedula LS, Zhao Y, Coates RM, Koyama T, Cane DE, Christianson DW. Exploring biosynthetic diversity with trichodiene synthase. Archives of Biochemistry and Biophysics. 466: 260-6. PMID 17678871 DOI: 10.1016/J.Abb.2007.06.016 |
0.821 |
|
| 2007 |
Di Costanzo L, Moulin M, Haertlein M, Meilleur F, Christianson DW. Expression, purification, assay, and crystal structure of perdeuterated human arginase I. Archives of Biochemistry and Biophysics. 465: 82-9. PMID 17562323 DOI: 10.1016/J.Abb.2007.04.036 |
0.472 |
|
| 2007 |
Di Costanzo L, Pique ME, Christianson DW. Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. Journal of the American Chemical Society. 129: 6388-9. PMID 17469833 DOI: 10.1021/Ja071567J |
0.448 |
|
| 2007 |
Krishnamurthy VM, Bohall BR, Kim CY, Moustakas DT, Christianson DW, Whitesides GM. Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II. Chemistry, An Asian Journal. 2: 94-105. PMID 17441142 DOI: 10.1002/Asia.200600360 |
0.565 |
|
| 2007 |
Christianson DW. Chemistry. Roots of biosynthetic diversity. Science (New York, N.Y.). 316: 60-1. PMID 17412944 DOI: 10.1126/Science.1141630 |
0.332 |
|
| 2007 |
Srivastava DK, Jude KM, Banerjee AL, Haldar M, Manokaran S, Kooren J, Mallik S, Christianson DW. Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II. Journal of the American Chemical Society. 129: 5528-37. PMID 17407288 DOI: 10.1021/Ja068359W |
0.719 |
|
| 2007 |
Shin H, Gennadios HA, Whittington DA, Christianson DW. Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC. Bioorganic & Medicinal Chemistry. 15: 2617-23. PMID 17296300 DOI: 10.1016/J.Bmc.2007.01.044 |
0.824 |
|
| 2007 |
Shishova EY, Di Costanzo L, Cane DE, Christianson DW. X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. Biochemistry. 46: 1941-51. PMID 17261032 DOI: 10.1021/Bi0622524 |
0.793 |
|
| 2007 |
De Vivo M, Ensing B, Dal Peraro M, Gomez GA, Christianson DW, Klein ML. Proton shuttles and phosphatase activity in soluble epoxide hydrolase. Journal of the American Chemical Society. 129: 387-94. PMID 17212419 DOI: 10.1021/Ja066150C |
0.668 |
|
| 2007 |
Di Costanzo L, Gomez GA, Christianson DW. Crystal structure of lactaldehyde dehydrogenase from Escherichia coli and inferences regarding substrate and cofactor specificity. Journal of Molecular Biology. 366: 481-93. PMID 17173928 DOI: 10.1016/J.Jmb.2006.11.023 |
0.709 |
|
| 2006 |
Gennadios HA, Christianson DW. Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding. Biochemistry. 45: 15216-23. PMID 17176043 DOI: 10.1021/Bi0619021 |
0.83 |
|
| 2006 |
Di Costanzo L, Flores LV, Christianson DW. Stereochemistry of guanidine-metal interactions: implications for L-arginine-metal interactions in protein structure and function. Proteins. 65: 637-42. PMID 16981206 DOI: 10.1002/Prot.21127 |
0.402 |
|
| 2006 |
Christianson DW. Structural biology and chemistry of the terpenoid cyclases. Chemical Reviews. 106: 3412-42. PMID 16895335 DOI: 10.1021/Cr050286W |
0.348 |
|
| 2006 |
Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase. Biochemistry. 45: 7940-8. PMID 16800620 DOI: 10.1021/Bi060823M |
0.842 |
|
| 2006 |
Christianson DW. Biochemistry. Five golden rings. Science (New York, N.Y.). 311: 1382-3. PMID 16527957 DOI: 10.1126/Science.1125298 |
0.344 |
|
| 2006 |
Jude KM, Banerjee AL, Haldar MK, Manokaran S, Roy B, Mallik S, Srivastava DK, Christianson DW. Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity. Journal of the American Chemical Society. 128: 3011-8. PMID 16506782 DOI: 10.1021/Ja057257N |
0.729 |
|
| 2006 |
Gomez GA, Morisseau C, Hammock BD, Christianson DW. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Science : a Publication of the Protein Society. 15: 58-64. PMID 16322563 DOI: 10.1110/Ps.051720206 |
0.68 |
|
| 2005 |
Colleluori DM, Reczkowski RS, Emig FA, Cama E, Cox JD, Scolnick LR, Compher K, Jude K, Han S, Viola RE, Christianson DW, Ash DE. Probing the role of the hyper-reactive histidine residue of arginase. Archives of Biochemistry and Biophysics. 444: 15-26. PMID 16266687 DOI: 10.1016/J.Abb.2005.09.009 |
0.795 |
|
| 2005 |
Vedula LS, Cane DE, Christianson DW. Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase. Biochemistry. 44: 12719-27. PMID 16171386 DOI: 10.1021/Bi0510476 |
0.816 |
|
| 2005 |
Di Costanzo L, Sabio G, Mora A, Rodriguez PC, Ochoa AC, Centeno F, Christianson DW. Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proceedings of the National Academy of Sciences of the United States of America. 102: 13058-63. PMID 16141327 DOI: 10.1073/Pnas.0504027102 |
0.489 |
|
| 2005 |
Vedula LS, Rynkiewicz MJ, Pyun HJ, Coates RM, Cane DE, Christianson DW. Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. Biochemistry. 44: 6153-63. PMID 15835903 DOI: 10.1021/Bi050059O |
0.831 |
|
| 2005 |
Christianson DW. Arginase: structure, mechanism, and physiological role in male and female sexual arousal. Accounts of Chemical Research. 38: 191-201. PMID 15766238 DOI: 10.1021/Ar040183K |
0.374 |
|
| 2005 |
Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism. The Journal of Biological Chemistry. 280: 16969-78. PMID 15705580 DOI: 10.1074/Jbc.M413560200 |
0.809 |
|
| 2004 |
Kim NN, Christianson DW, Traish AM. Role of arginase in the male and female sexual arousal response. The Journal of Nutrition. 134: 2873S-2879S; discuss. PMID 15465804 DOI: 10.1093/Jn/134.10.2873S |
0.315 |
|
| 2004 |
Shin H, Cama E, Christianson DW. Design of amino acid aldehydes as transition-state analogue inhibitors of arginase. Journal of the American Chemical Society. 126: 10278-84. PMID 15315440 DOI: 10.1021/Ja047788W |
0.824 |
|
| 2004 |
Cama E, Pethe S, Boucher JL, Han S, Emig FA, Ash DE, Viola RE, Mansuy D, Christianson DW. Inhibitor coordination interactions in the binuclear manganese cluster of arginase. Biochemistry. 43: 8987-99. PMID 15248756 DOI: 10.1021/Bi0491705 |
0.82 |
|
| 2004 |
Gomez GA, Morisseau C, Hammock BD, Christianson DW. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochemistry. 43: 4716-23. PMID 15096040 DOI: 10.1021/Bi036189J |
0.691 |
|
| 2004 |
Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. The Journal of Biological Chemistry. 279: 7223-8. PMID 14660577 DOI: 10.1074/Jbc.M310809200 |
0.304 |
|
| 2003 |
Cama E, Shin H, Christianson DW. Design of amino acid sulfonamides as transition-state analogue inhibitors of arginase. Journal of the American Chemical Society. 125: 13052-7. PMID 14570477 DOI: 10.1021/ja036365b |
0.827 |
|
| 2003 |
Cama E, Colleluori DM, Emig FA, Shin H, Kim SW, Kim NN, Traish AM, Ash DE, Christianson DW. Human arginase II: crystal structure and physiological role in male and female sexual arousal. Biochemistry. 42: 8445-51. PMID 12859189 DOI: 10.2210/Pdb1Pq3/Pdb |
0.802 |
|
| 2003 |
Cama E, Emig FA, Ash DE, Christianson DW. Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I. Biochemistry. 42: 7748-58. PMID 12820884 DOI: 10.1021/Bi030074Y |
0.828 |
|
| 2003 |
Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 8146-50. PMID 12819349 DOI: 10.1073/Pnas.1432990100 |
0.439 |
|
| 2002 |
Whittington DA, Wise ML, Urbansky M, Coates RM, Croteau RB, Christianson DW. Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase. Proceedings of the National Academy of Sciences of the United States of America. 99: 15375-80. PMID 12432096 DOI: 10.1073/Pnas.232591099 |
0.441 |
|
| 2002 |
Seemann M, Zhai G, de Kraker JW, Paschall CM, Christianson DW, Cane DE. Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis. Journal of the American Chemical Society. 124: 7681-9. PMID 12083921 DOI: 10.1021/Ja026058Q |
0.775 |
|
| 2002 |
Jude KM, Wright SK, Tu C, Silverman DN, Viola RE, Christianson DW. Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Biochemistry. 41: 2485-91. PMID 11851394 DOI: 10.1021/Bi015808Q |
0.724 |
|
| 2002 |
Kim CY, Whittington DA, Chang JS, Liao J, May JA, Christianson DW. Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. Journal of Medicinal Chemistry. 45: 888-93. PMID 11831900 DOI: 10.1021/Jm010163D |
0.609 |
|
| 2002 |
Rynkiewicz MJ, Cane DE, Christianson DW. X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity. Biochemistry. 41: 1732-41. PMID 11827517 DOI: 10.1021/Bi011960G |
0.518 |
|
| 2002 |
Grzybowski BA, Ishchenko AV, Kim CY, Topalov G, Chapman R, Christianson DW, Whitesides GM, Shakhnovich EI. Combinatorial computational method gives new picomolar ligands for a known enzyme. Proceedings of the National Academy of Sciences of the United States of America. 99: 1270-3. PMID 11818565 DOI: 10.1073/Pnas.032673399 |
0.566 |
|
| 2002 |
Madder RD, Kim CY, Chandra PP, Doyon JB, Baird TA, Fierke CA, Christianson DW, Voet JG, Jain A. Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase. The Journal of Organic Chemistry. 67: 582-4. PMID 11798333 DOI: 10.1021/Jo0159385 |
0.571 |
|
| 2001 |
Rynkiewicz MJ, Cane DE, Christianson DW. Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade Proceedings of the National Academy of Sciences of the United States of America. 98: 13543-13548. PMID 11698643 DOI: 10.1073/Pnas.231313098 |
0.498 |
|
| 2001 |
Kim CY, Chandra PP, Jain A, Christianson DW. Fluoroaromatic - Fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II Journal of the American Chemical Society. 123: 9620-9627. PMID 11572683 DOI: 10.1021/Ja011034P |
0.56 |
|
| 2001 |
Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW. Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 9545-50. PMID 11493685 DOI: 10.1073/Pnas.161301298 |
0.391 |
|
| 2001 |
Lavulo LT, Sossong TM, Brigham-Burke MR, Doyle ML, Cox JD, Christianson DW, Ash DE. Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid. The Journal of Biological Chemistry. 276: 14242-8. PMID 11278703 DOI: 10.1074/jbc.M010575200 |
0.61 |
|
| 2001 |
Cox JD, Cama E, Colleluori DM, Pethe S, Boucher JL, Mansuy D, Ash DE, Christianson DW. Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry. 40: 2689-701. PMID 11258880 DOI: 10.1021/Bi002318+ |
0.812 |
|
| 2001 |
Kim NN, Cox JD, Baggio RF, Emig FA, Mistry SK, Harper SL, Speicher DW, Morris SM, Ash DE, Traish A, Christianson DW. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 40: 2678-88. PMID 11258879 DOI: 10.1021/Bi002317H |
0.642 |
|
| 2000 |
Cox JD, Hunt JA, Compher KM, Fierke CA, Christianson DW. Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry. 39: 13687-94. PMID 11076507 DOI: 10.1021/Bi001649J |
0.647 |
|
| 2000 |
Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A. Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II Organic Letters. 2: 2557-8. PMID 10956546 |
0.458 |
|
| 2000 |
Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW. Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. The Journal of Biological Chemistry. 275: 25533-9. PMID 10825154 DOI: 10.1074/Jbc.M000433200 |
0.691 |
|
| 2000 |
Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A. Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II. Organic Letters. 2: 1189-92. PMID 10810704 DOI: 10.1021/Ol005608R |
0.591 |
|
| 2000 |
Yamada T, Morisseau C, Maxwell JE, Argiriadi MA, Christianson DW, Hammock BD. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. The Journal of Biological Chemistry. 275: 23082-8. PMID 10806198 DOI: 10.1074/Jbc.M001464200 |
0.327 |
|
| 2000 |
Argiriadi MA, Morisseau C, Goodrow MH, Dowdy DL, Hammock BD, Christianson DW. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. The Journal of Biological Chemistry. 275: 15265-70. PMID 10747889 DOI: 10.1074/Jbc.M000278200 |
0.341 |
|
| 2000 |
Ash DE, Cox JD, Christianson DW. Arginase: a binuclear manganese metalloenzyme. Metal Ions in Biological Systems. 37: 407-28. PMID 10693141 |
0.539 |
|
| 2000 |
Kim CY, Chang JS, Doyon JB, Baird TT, Fierke CA, Jain A, Christianson DW. Contribution of fluorine to protein - Ligand affinity in the binding of fluoroaromatic inhibitors to carbonic anhydrase II Journal of the American Chemical Society. 122: 12125-12134. DOI: 10.1021/Ja002627N |
0.552 |
|
| 1999 |
Paschall CM, Hasserodt J, Jones T, Lerner RA, Janda KD, Christianson DW. Convergence of Catalytic Antibody and Terpene Cyclase Mechanisms: Polyene Cyclization Directed by Carbocation-π Interactions. Angewandte Chemie (International Ed. in English). 38: 1743-1747. PMID 29711206 DOI: 10.1002/(Sici)1521-3773(19990614)38:12<1743::Aid-Anie1743>3.0.Co;2-3 |
0.816 |
|
| 1999 |
Christianson DW, Cox JD. Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes. Annual Review of Biochemistry. 68: 33-57. PMID 10872443 DOI: 10.1146/annurev.biochem.68.1.33 |
0.583 |
|
| 1999 |
Baggio R, Cox JD, Harper SL, Speicher DW, Christianson DW. A new chromophoric assay for arginase activity. Analytical Biochemistry. 276: 251-3. PMID 10603248 DOI: 10.1006/Abio.1999.4355 |
0.534 |
|
| 1999 |
Cox JD, Kim NN, Traish AM, Christianson DW. Arginase-boronic acid complex highlights a physiological role in erectile function. Nature Structural Biology. 6: 1043-7. PMID 10542097 DOI: 10.1038/14929 |
0.653 |
|
| 1999 |
Argiriadi MA, Morisseau C, Hammock BD, Christianson DW. Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 96: 10637-42. PMID 10485878 DOI: 10.1073/Pnas.96.19.10637 |
0.449 |
|
| 1999 |
Paschall CM, Hasserodt J, Jones T, Lerner RA, Janda KD, Christianson DW. Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation - π interactions Angewandte Chemie - International Edition. 38: 1743-1747. DOI: 10.1002/(SICI)1521-3773(19990614)38:12<1743::AID-ANIE1743>3.0.CO;2-3 |
0.767 |
|
| 1999 |
Paschall CM, Hasserodt J, Jones T, Lerner RA, Janda KD, Christianson DW. Konvergenz der Mechanismen eines katalytischen Antikörpers und einer Terpen-Cyclase: eine durch Carbokation-π-Elektronen-Wechselwirkung gesteuerte Polyencyclisierung Angewandte Chemie. 111: 1859-1864. DOI: 10.1002/(Sici)1521-3757(19990614)111:12<1859::Aid-Ange1859>3.0.Co;2-F |
0.753 |
|
| 1998 |
Lesburg CA, Caruthers JM, Paschall CM, Christianson DW. Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism. Current Opinion in Structural Biology. 8: 695-703. PMID 9914250 DOI: 10.1016/S0959-440X(98)80088-2 |
0.819 |
|
| 1998 |
Boriack-Sjodin PA, Zeitlin S, Chen HH, Crenshaw L, Gross S, Dantanarayana A, Delgado P, May JA, Dean T, Christianson DW. Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Science : a Publication of the Protein Society. 7: 2483-9. PMID 9865942 DOI: 10.1002/Pro.5560071201 |
0.472 |
|
| 1998 |
Niranjanakumari S, Stams T, Crary SM, Christianson DW, Fierke CA. Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA. Proceedings of the National Academy of Sciences of the United States of America. 95: 15212-7. PMID 9860948 DOI: 10.1073/Pnas.95.26.15212 |
0.322 |
|
| 1998 |
Ash DE, Scolnick LR, Kanyo ZF, Vockley JG, Cederbaum SD, Christianson DW. Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase. Molecular Genetics and Metabolism. 64: 243-9. PMID 9758714 DOI: 10.1006/Mgme.1998.2677 |
0.345 |
|
| 1998 |
Stams T, Niranjanakumari S, Fierke CA, Christianson DW. Ribonuclease P protein structure: evolutionary origins in the translational apparatus. Science (New York, N.Y.). 280: 752-5. PMID 9563955 DOI: 10.1126/Science.280.5364.752 |
0.344 |
|
| 1998 |
Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Science : a Publication of the Protein Society. 7: 556-63. PMID 9541386 DOI: 10.1002/Pro.5560070303 |
0.439 |
|
| 1998 |
Lukacs CM, Rubin H, Christianson DW. Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction. Biochemistry. 37: 3297-304. PMID 9521649 DOI: 10.1021/Bi972359E |
0.418 |
|
| 1997 |
Christianson DW. Structural chemistry and biology of manganese metalloenzymes. Progress in Biophysics and Molecular Biology. 67: 217-52. PMID 9446936 DOI: 10.1016/S0079-6107(97)88477-5 |
0.358 |
|
| 1997 |
Lesburg CA, Huang C, Christianson DW, Fierke CA. Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry. 36: 15780-91. PMID 9398308 DOI: 10.1021/Bi971296X |
0.44 |
|
| 1997 |
Lesburg CA, Zhai G, Cane DE, Christianson DW. Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology. Science (New York, N.Y.). 277: 1820-4. PMID 9295272 DOI: 10.1126/Science.277.5333.1820 |
0.473 |
|
| 1997 |
Scolnick LR, Kanyo ZF, Cavalli RC, Ash DE, Christianson DW. Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function. Biochemistry. 36: 10558-65. PMID 9265637 DOI: 10.1021/Bi970800V |
0.418 |
|
| 1997 |
Baggio R, Elbaum D, Kanyo ZF, Carroll PJ, Cavalli RC, Ash DE, Christianson DW. Inhibition of Mn2+ 2-arginase by borate leads to the design of a transition state analogue inhibitor, 2(S)-amino-6-boronohexanoic acid Journal of the American Chemical Society. 119: 8107-8108. DOI: 10.1021/Ja971312D |
0.313 |
|
| 1997 |
Scolnick LR, Clements AM, Liao J, Crenshaw L, Hellberg M, May J, Dean TR, Christianson DW. Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase II Journal of the American Chemical Society. 119: 850-851. DOI: 10.1021/Ja963832Z |
0.316 |
|
| 1996 |
Scolnick LR, Christianson DW. X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis. Biochemistry. 35: 16429-34. PMID 8987974 DOI: 10.1021/Bi9617872 |
0.39 |
|
| 1996 |
Stams T, Nair SK, Okuyama T, Waheed A, Sly WS, Christianson DW. Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 93: 13589-94. PMID 8942978 DOI: 10.1073/Pnas.93.24.13589 |
0.644 |
|
| 1996 |
Kanyo ZF, Scolnick LR, Ash DE, Christianson DW. Structure of a unique binuclear manganese cluster in arginase. Nature. 383: 554-7. PMID 8849731 DOI: 10.1038/383554A0 |
0.42 |
|
| 1996 |
Lukacs CM, Zhong JQ, Plotnick MI, Rubin H, Cooperman BS, Christianson DW. Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement. Nature Structural Biology. 3: 888-93. PMID 8836107 DOI: 10.1038/Nsb1096-888 |
0.339 |
|
| 1996 |
Stavridi ES, O'Malley K, Lukacs CM, Moore WT, Lambris JD, Christianson DW, Rubin H, Cooperman BS. Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis. Biochemistry. 35: 10608-15. PMID 8718849 DOI: 10.1021/Bi9605806 |
0.425 |
|
| 1996 |
Huang CC, Lesburg CA, Kiefer LL, Fierke CA, Christianson DW. Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry. 35: 3439-46. PMID 8639494 DOI: 10.1021/Bi9526692 |
0.446 |
|
| 1996 |
Nair SK, Elbaum D, Christianson DW. Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor. The Journal of Biological Chemistry. 271: 1003-7. PMID 8557623 DOI: 10.1074/Jbc.271.2.1003 |
0.649 |
|
| 1996 |
Elbaum D, Nair SK, Patchan MW, Thompson RB, Christianson DW. Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor Journal of the American Chemical Society. 118: 8381-8387. DOI: 10.1021/Ja954102E |
0.581 |
|
| 1996 |
Christianson DW, Fierke CA. Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design Accounts of Chemical Research. 29: 331-339. DOI: 10.1021/Ar9501232 |
0.319 |
|
| 1995 |
Ippolito JA, Nair SK, Alexander RS, Kiefer LL, Fierke CA, Christianson DW. Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site. Protein Engineering. 8: 975-80. PMID 8771178 DOI: 10.1093/Protein/8.10.975 |
0.62 |
|
| 1995 |
Lesburg CA, Lloyd MD, Cane DE, Christianson DW. Crystallization and preliminary X-ray diffraction analysis of recombinant pentalenene synthase. Protein Science : a Publication of the Protein Society. 4: 2436-8. PMID 8563643 DOI: 10.1002/Pro.5560041124 |
0.33 |
|
| 1995 |
Ippolito JA, Baird TT, McGee SA, Christianson DW, Fierke CA. Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proceedings of the National Academy of Sciences of the United States of America. 92: 5017-21. PMID 7761440 DOI: 10.1073/Pnas.92.11.5017 |
0.425 |
|
| 1995 |
Nair SK, Krebs JF, Christianson DW, Fierke CA. Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. Biochemistry. 34: 3981-9. PMID 7696263 DOI: 10.1021/Bi00012A016 |
0.662 |
|
| 1995 |
Boriack PA, Christianson DW, Kingery-Wood J, Whitesides GM. Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. Journal of Medicinal Chemistry. 38: 2286-91. PMID 7608893 DOI: 10.1021/Jm00013A004 |
0.319 |
|
| 1995 |
Boriack-Sjodin PA, Heck RW, Laipis PJ, Silverman DN, Christianson DW. Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design. Proceedings of the National Academy of Sciences of the United States of America. 92: 10949-53. PMID 7479916 DOI: 10.1073/Pnas.92.24.10949 |
0.347 |
|
| 1995 |
Lesburg CA, Christianson DW. X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site Journal of the American Chemical Society. 117: 6838-6844. DOI: 10.2210/Pdb1Cng/Pdb |
0.315 |
|
| 1995 |
Katz DS, Christianson DW. Structural aspects of the serpin reaction coordinate Perspectives in Drug Discovery and Design. 2: 459-474. DOI: 10.1007/Bf02172038 |
0.433 |
|
| 1994 |
Smith GM, Alexander RS, Christianson DW, McKeever BM, Ponticello GS, Springer JP, Randall WC, Baldwin JJ, Habecker CN. Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors Protein Science. 3: 118-125. PMID 8142888 DOI: 10.1002/Pro.5560030115 |
0.383 |
|
| 1994 |
Jain A, Whitesides GM, Alexander RS, Christianson DW. Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors. Journal of Medicinal Chemistry. 37: 2100-5. PMID 8027991 DOI: 10.1021/Jm00039A023 |
0.444 |
|
| 1994 |
Katz DS, White SP, Huang W, Kumar R, Christianson DW. Structure determination of aquomet porcine hemoglobin at 2.8 A resolution. Journal of Molecular Biology. 244: 541-53. PMID 7990139 DOI: 10.1006/Jmbi.1994.1751 |
0.388 |
|
| 1994 |
Ippolito JA, Christianson DW. Structural consequences of redesigning a protein-zinc binding site. Biochemistry. 33: 15241-9. PMID 7803386 DOI: 10.2210/Pdb1Cvd/Pdb |
0.466 |
|
| 1994 |
Wei A, Rubin H, Cooperman BS, Christianson DW. Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop. Nature Structural Biology. 1: 251-8. PMID 7656054 DOI: 10.1038/Nsb0494-251 |
0.379 |
|
| 1994 |
Cappalonga Bunn AM, Alexander RS, Christianson DW. Mapping protein-peptide affinity: Binding of peptidylsulfonamide inhibitors to human carbonic anhydrase II Journal of the American Chemical Society. 116: 5063-5068. DOI: 10.1021/Ja00091A006 |
0.301 |
|
| 1994 |
Nair SK, Ludwig PA, Christianson DW. Two-site binding of phenol in the active site of human carbonic anhydrase II: Structural implications for substrate association Journal of the American Chemical Society. 116: 3659-3660. DOI: 10.1021/Ja00087A086 |
0.611 |
|
| 1993 |
Nair SK, Christianson DW. Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II Biochemistry. 32: 4506-4514. PMID 8485129 DOI: 10.1021/Bi00068A005 |
0.623 |
|
| 1993 |
Nair SK, Christianson DW. Crystallographic studies of azide binding to human carbonic anhydrase II European Journal of Biochemistry. 213: 507-515. PMID 8477723 DOI: 10.1111/J.1432-1033.1993.Tb17788.X |
0.649 |
|
| 1993 |
Alexander RS, Kiefer LL, Fierke CA, Christianson DW. Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Biochemistry. 32: 1510-8. PMID 8431430 DOI: 10.1021/Bi00057A015 |
0.472 |
|
| 1993 |
Ippolito JA, Christianson DW. Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II Biochemistry. 32: 9901-9905. PMID 8399159 DOI: 10.1021/Bi00089A005 |
0.483 |
|
| 1993 |
Mann Hyung Lee, Pankratz HS, Wang S, Scott RA, Finnegan MG, Johnson MK, Ippolito JA, Christianson DW, Hausinger RP. Purification and characterization of Klebsiella aerogenes UreE protein: A nickel-binding protein that functions in urease metallocenter assembly Protein Science. 2: 1042-1052. PMID 8318889 DOI: 10.1002/Pro.5560020617 |
0.392 |
|
| 1993 |
Krebs JF, Ippolito JA, Christianson DW, Fierke CA. Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II Journal of Biological Chemistry. 268: 27458-27466. PMID 8262987 DOI: 10.2210/Pdb1Cva/Pdb |
0.363 |
|
| 1993 |
Katz DS, Christianson DW. Modeling the uncleaved serpin antichymotrypsin and its chymotrypsin complex Protein Engineering. 6: 701-709. PMID 8248093 DOI: 10.1093/Protein/6.7.701 |
0.387 |
|
| 1993 |
Katz DS, Wei A, Zhong Q, Rubin H, Cooperman BS, Christianson DW. Crystallization and atomic resolution X-ray diffraction analysis of antichymotrypsin variants Biochemical and Biophysical Research Communications. 196: 752-757. PMID 8240351 DOI: 10.1006/Bbrc.1993.2313 |
0.343 |
|
| 1993 |
Christianson DW. Structure and Energetics of a Non-Proline cis-Peptidyl Linkage in a Proline-202→ Alanine Carbonic Anhydrase II Variant Biochemistry. 32: 10944-10949. PMID 8218160 DOI: 10.1021/Bi00092A003 |
0.379 |
|
| 1993 |
Kiefer LL, Ippolito JA, Fierke CA, Christianson DW. Redesigning The Zinc-Binding Site Of Human Carbonic Anhydrase-Ii - Structure Of A His2Asp-Zn2+ Metal Coordination Polyhedron. Journal of the American Chemical Society. 115: 12581-12582. DOI: 10.1021/Ja00079A046 |
0.385 |
|
| 1992 |
Wei A, Rubin H, Cooperman BS, Schechter N, Christianson DW. Crystallization, activity assay and preliminary X-ray diffraction analysis of the uncleaved form of the serpin antichymotrypsin Journal of Molecular Biology. 226: 273-276. PMID 1619657 DOI: 10.1016/0022-2836(92)90140-F |
0.338 |
|
| 1992 |
Kanyo ZF, Chen CY, Daghigh F, Ash DE, Christianson DW. Crystallization and oligomeric structure of rat liver arginase Journal of Molecular Biology. 224: 1175-1177. PMID 1569574 DOI: 10.1016/0022-2836(92)90479-4 |
0.34 |
|
| 1992 |
Cappalonga AM, Alexander RS, Christianson DW. Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc enzymes Journal of Biological Chemistry. 267: 19192-19197. PMID 1527041 |
0.403 |
|
| 1992 |
Ippolito JA, Christianson DW. The contribution of halogen atoms to protein-ligand interactions International Journal of Biological Macromolecules. 14: 193-197. PMID 1504038 DOI: 10.1016/S0141-8130(05)80026-1 |
0.388 |
|
| 1991 |
Alexander RS, Nair SK, Christianson DW. Engineering the hydrophobic pocket of carbonic anhydrase II. Biochemistry. 30: 11064-72. PMID 1932029 DOI: 10.1021/Bi00110A008 |
0.638 |
|
| 1991 |
Nair SK, Calderone TL, Christianson DW, Fierke CA. Altering the mouth of a hydrophobic pocket: Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121 Journal of Biological Chemistry. 266: 17320-17325. PMID 1910042 DOI: 10.2210/Pdb12Ca/Pdb |
0.63 |
|
| 1991 |
Krebs JF, Fierke CA, Alexander RS, Christianson DW. Conformational mobility of His-64 in the Thr-200 → ser mutant of human carbonic anhydrase II Biochemistry. 30: 9153-9160. PMID 1909891 DOI: 10.1021/Bi00102A005 |
0.412 |
|
| 1991 |
Christianson DW. Structural biology of zinc Advances in Protein Chemistry. 42: 281-355. PMID 1793007 DOI: 10.1016/S0065-3233(08)60538-0 |
0.422 |
|
| 1991 |
Nair SK, Christianson DW. Structural properties of human carbonic anhydrase II at pH 9.5 Biochemical and Biophysical Research Communications. 181: 579-584. PMID 1755840 DOI: 10.1016/0006-291X(91)91229-6 |
0.585 |
|
| 1991 |
Nair SK, Christianson DW. Unexpected pH-dependent conformation of his-64, the proton shuttle of carbonic anhydrase II Journal of the American Chemical Society. 113: 9455-9458. DOI: 10.1021/Ja00025A005 |
0.532 |
|
| 1990 |
Christianson DW, Alexander RS. Another catalytic triad? Nature. 346: 225. PMID 2374586 DOI: 10.1038/346225B0 |
0.324 |
|
| 1990 |
Ippolito JA, Alexander RS, Christianson DW. Hydrogen bond stereochemistry in protein structure and function Journal of Molecular Biology. 215: 457-471. PMID 2231715 DOI: 10.1016/S0022-2836(05)80364-X |
0.324 |
|
| 1990 |
Alexander RS, Kanyo ZF, Chirlian LE, Christianson DW. Stereochemistry of phosphate-lewis acid interactions: Implications for nucleic acid structure and recognition Journal of the American Chemical Society. 112: 933-937. DOI: 10.1021/Ja00159A004 |
0.368 |
|
| 1989 |
Christianson DW, Mangani S, Shoham G, Lipscomb WN. Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. The Journal of Biological Chemistry. 264: 12849-53. PMID 2568989 |
0.507 |
|
| 1989 |
Christianson DW, Alexander RS. Carboxylate-histidine-zinc interactions in protein structure and function Journal of the American Chemical Society. 111: 6412-6419. DOI: 10.1021/Ja00198A065 |
0.44 |
|
| 1988 |
Shoham G, Christianson DW, Oren DA. Complex between carboxypeptidase A and a hydrated ketomethylene substrate analogue Proceedings of the National Academy of Sciences of the United States of America. 85: 684-688. PMID 3422451 DOI: 10.1073/Pnas.85.3.684 |
0.696 |
|
| 1988 |
Christianson DW, Lipscomb WN. Comparison of carboxypeptidase A and thermolysin: Inhibition by phosphonamidates Journal of the American Chemical Society. 110: 5560-5565. DOI: 10.1021/Ja00224A047 |
0.444 |
|
| 1987 |
Christianson DW, David PR, Lipscomb WN. Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue. Proceedings of the National Academy of Sciences of the United States of America. 84: 1512-5. PMID 3470737 DOI: 10.1073/Pnas.84.6.1512 |
0.75 |
|
| 1987 |
Christianson DW, Lipscomb WN. Carboxypeptidase A: novel enzyme-substrate-product complex Journal of the American Chemical Society. 109: 5536-5538. DOI: 10.1021/Ja00252A046 |
0.525 |
|
| 1987 |
Christianson DW, Lipscomb WN. Carboxypeptidase A: Novel enzyme-substrate-product complex [12] Journal of the American Chemical Society. 109: 5536-5538. |
0.459 |
|
| 1986 |
Christianson DW, Lipscomb WN. Structure of the complex between an unexpectedly hydrolyzed phosphonamidate inhibitor and carboxypeptidase A. Journal of the American Chemical Society. 108: 545-6. PMID 22175497 DOI: 10.1021/Ja00263A052 |
0.543 |
|
| 1986 |
Christianson DW, Lipscomb WN. X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature. Proceedings of the National Academy of Sciences of the United States of America. 83: 7568-72. PMID 3463986 DOI: 10.1073/Pnas.83.20.7568 |
0.612 |
|
| 1986 |
Christianson DW, Lipscomb WN. The complex between carboxypeptidase A and a possible transition-state analogue: Mechanistic inferences from high-resolution X-ray structures of enzyme-inhibitor complexes Journal of the American Chemical Society. 108: 4998-5003. DOI: 10.1021/Ja00276A048 |
0.549 |
|
| 1985 |
Christianson DW, Lipscomb WN. Binding of a possible transition state analogue to the active site of carboxypeptidase A. Proceedings of the National Academy of Sciences of the United States of America. 82: 6840-4. PMID 3863130 DOI: 10.1073/Pnas.82.20.6840 |
0.609 |
|
| 1985 |
Christianson DW, Kuo LC, Lipscomb WN. Novel structure of the complex between carboxypeptidase A and a ketonic substrate analogue Journal of the American Chemical Society. 107: 8281-8283. DOI: 10.1021/Ja00312A089 |
0.564 |
|
| 1985 |
Christianson DW, Lipscomb WN. A molecular orbital evaluation of possible factors affecting the homolytic activation of coenzyme B12 Journal of the American Chemical Society. 107: 2682-2686. DOI: 10.1021/Ja00295A021 |
0.419 |
|
| 1984 |
Shoham G, Christianson DW, Bartsch RA, Heo GS, Olsher U, Lipscomb WN. Crystal and molecular structure of the complex between sym-dibenzo-14-crown-4-oxyacetate and lithium(1+) ion, [C20H21O7]-.cntdot.Li+.cntdot.7.5H2O Journal of the American Chemical Society. 106: 1280-1285. DOI: 10.1021/Ja00317A018 |
0.677 |
|
| 1984 |
SHOHAM G, CHRISTIANSON DW, BARTSCH RA, HEO GS, OLSHER U, LIPSCOMB WN. ChemInform Abstract: CRYSTAL AND MOLECULAR STRUCTURE OF THE COMPLEX BETWEEN SYM-DIBENZO-14-CROWN-4-OXYACETATE AND LITHIUM(1+) ION, (C20H21O7)-.CNTDOT.LI+.CNTDOT.7.5H2O Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198424057 |
0.65 |
|
| 1984 |
Shoham G, Christianson DW, Bartsch RA, Heo GS, Olsher U, Lipscomb WN. Crystal and molecular structure of the complex between sym-dibenzo-14-crown-4-oxyacetate and Li+, [C20H21O7]-·Li +·7.5H2O Journal of the American Chemical Society. 106: 1280-1285. |
0.453 |
|
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