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Velpandi Ayyavoo - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Molecular Biology, Immunology
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Dos Reis RS, Sant S, Ayyavoo V. Three-Dimensional Human Brain Organoids to Model HIV-1 Neuropathogenesis. Methods in Molecular Biology (Clifton, N.J.). 2610: 167-178. PMID 36534290 DOI: 10.1007/978-1-0716-2895-9_14  0.408
2020 Dos Reis RS, Sant S, Keeney H, Wagner MCE, Ayyavoo V. Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia. Scientific Reports. 10: 15209. PMID 32938988 DOI: 10.1038/S41598-020-72214-0  0.581
2018 Guha D, Wagner MCE, Ayyavoo V. Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury. Journal of Neuroinflammation. 15: 126. PMID 29703241 DOI: 10.1186/S12974-018-1160-2  0.614
2016 Venkatachari NJ, Jain S, Walker L, Bivalkar-Mehla S, Chattopadhyay A, Bar-Joseph Z, Rinaldo C, Ragin A, Seaberg E, Levine A, Becker J, Martin E, Sacktor N, Ayyavoo V. Transcriptome analyses identify key cellular factors associated with HIV-1 associated neuropathogenesis in infected men. Aids (London, England). PMID 28005686 DOI: 10.1097/Qad.0000000000001379  0.562
2016 Jain S, Arrais J, Venkatachari NJ, Ayyavoo V, Bar-Joseph Z. Reconstructing the temporal progression of HIV-1 immune response pathways. Bioinformatics (Oxford, England). 32: i253-i261. PMID 27307624 DOI: 10.1093/Bioinformatics/Btw254  0.377
2016 Guha D, Mancini A, Sparks J, Ayyavoo V. HIV-1 Infection Dysregulates Cell Cycle Regulatory Protein p21 in CD4+ T Cells through miR-20a and miR-106b Regulation. Journal of Cellular Biochemistry. PMID 26755399 DOI: 10.1002/Jcb.25489  0.561
2015 Venkatachari NJ, Zerbato JM, Jain S, Mancini AE, Chattopadhyay A, Sluis-Cremer N, Bar-Joseph Z, Ayyavoo V. Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch. Retrovirology. 12: 85. PMID 26438393 DOI: 10.1186/S12977-015-0211-3  0.591
2015 Guha D, Klamar CR, Reinhart T, Ayyavoo V. Transcriptional Regulation of CXCL5 in HIV-1-Infected Macrophages and Its Functional Consequences on CNS Pathology. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 35: 373-84. PMID 25536401 DOI: 10.1089/Jir.2014.0135  0.593
2014 Zaccard CR, Watkins SC, Ayyavoo V, Rinaldo CR, Mailliard RB. HIV's ticket to ride: Cytotoxic T-lymphocyte-activated dendritic cells exploited for virus intercellular transfer. Aids Research and Human Retroviruses. 30: 1023-4. PMID 25354022 DOI: 10.1089/Aid.2014.0218  0.631
2014 Srinivasan A, Rastogi A, Ayyavoo V, Srivastava S. Nanotechnology-based approaches for the development of diagnostics, therapeutics, and vaccines. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33: 186-91. PMID 24937250 DOI: 10.1089/Mab.2014.0045  0.367
2014 Thapa DR, Hussain SK, Tran WC, Dʼsouza G, Bream JH, Achenback CJ, Ayyavoo V, Detels R, Martínez-Maza O. Serum microRNAs in HIV-infected individuals as pre-diagnosis biomarkers for AIDS-NHL. Journal of Acquired Immune Deficiency Syndromes (1999). 66: 229-37. PMID 24675587 DOI: 10.1097/Qai.0000000000000146  0.445
2014 Hadi K, Walker LA, Guha D, Murali R, Watkins SC, Tarwater P, Srinivasan A, Ayyavoo V. Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions. The Journal of General Virology. 95: 700-11. PMID 24300552 DOI: 10.1099/Vir.0.059576-0  0.575
2013 Guha D, Ayyavoo V. Innate immune evasion strategies by human immunodeficiency virus type 1. Isrn Aids. 2013: 954806. PMID 24052891 DOI: 10.1155/2013/954806  0.494
2013 Zych C, Domling A, Ayyavoo V. Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization. Drug Design, Development and Therapy. 7: 403-12. PMID 23737660 DOI: 10.2147/Dddt.S44139  0.546
2013 Duskova K, Nagilla P, Le HS, Iyer P, Thalamuthu A, Martinson J, Bar-Joseph Z, Buchanan W, Rinaldo C, Ayyavoo V. MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts. Bmc Infectious Diseases. 13: 250. PMID 23721325 DOI: 10.1186/1471-2334-13-250  0.47
2012 Gupta A, Nagilla P, Le H, Bunney C, Zych C, Thalamuthu A, Bar-Joseph Z, Mathavan S, Ayyavoo V. Retraction: Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1) Plos One. 7. PMID 22952567 DOI: 10.1371/Annotation/D28D38B2-41A3-42A6-B421-68F9460A676D  0.311
2012 Guha D, Nagilla P, Redinger C, Srinivasan A, Schatten GP, Ayyavoo V. Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells. Journal of Neuroinflammation. 9: 138. PMID 22727020 DOI: 10.1186/1742-2094-9-138  0.471
2012 Gupta P, Ratner D, Ding M, Patterson B, Rohan LC, Reinhart TA, Ayyavoo V, Huang X, Patton DL, Ramratnam B, Cole AM. Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture. Journal of Acquired Immune Deficiency Syndromes (1999). 60: 455-61. PMID 22592582 DOI: 10.1097/Qai.0B013E318258B420  0.447
2012 Mehla R, Ayyavoo V. Gene array studies in HIV-1 infection. Current Hiv/Aids Reports. 9: 34-43. PMID 22184032 DOI: 10.1007/S11904-011-0100-X  0.605
2011 Gupta A, Nagilla P, Le HS, Bunney C, Zych C, Thalamuthu A, Bar-Joseph Z, Mathavan S, Ayyavoo V. Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). Plos One. 6: e22730. PMID 21829495 DOI: 10.1371/Journal.Pone.0022730  0.396
2010 Venkatachari NJ, Walker LA, Tastan O, Le T, Dempsey TM, Li Y, Yanamala N, Srinivasan A, Klein-Seetharaman J, Montelaro RC, Ayyavoo V. Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles. Virology Journal. 7: 119. PMID 20529298 DOI: 10.1186/1743-422X-7-119  0.515
2010 Schaubert KL, Price DA, Salkowitz JR, Sewell AK, Sidney J, Asher TE, Blondelle SE, Adams S, Marincola FM, Joseph A, Sette A, Douek DC, Ayyavoo V, Storkus W, Leung MY, et al. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology. 40: 1950-62. PMID 20432235 DOI: 10.1002/Eji.200940079  0.57
2009 Venkatachari NJ, Alber S, Watkins SC, Ayyavoo V. HIV-1 infection of DC: evidence for the acquisition of virus particles from infected T cells by antigen uptake mechanism. Plos One. 4: e7470. PMID 19829715 DOI: 10.1371/Journal.Pone.0007470  0.541
2009 Majumder B, Venkatachari NJ, Srinivasan A, Ayyavoo V. HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr). Current Hiv Research. 7: 169-77. PMID 19275586 DOI: 10.2174/157016209787581445  0.651
2009 Kan-Mitchell J, Nyakeriga A, Salkowitz J, Costanzo M, Sidney J, Sette A, Ayyavoo V. P17-24. Interfering overlapping epitopes contribute to the subdominance of an HLA-A2-restricted HIV Gag-specific epitope Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P306  0.538
2008 Srinivasan A, Ayyavoo V, Mahalingam S, Kannan A, Boyd A, Datta D, Kalyanaraman VS, Cristillo A, Collman RG, Morellet N, Sawaya BE, Murali R. A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes. Virology Journal. 5: 99. PMID 18721481 DOI: 10.1186/1743-422X-5-99  0.536
2008 Venkatachari NJ, Buchanan WG, Ayyavoo V. Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo. Virology. 376: 140-53. PMID 18440040 DOI: 10.1016/J.Virol.2008.03.015  0.449
2008 Majumder B, Venkatachari NJ, O'Leary S, Ayyavoo V. Infection with Vpr-positive human immunodeficiency virus type 1 impairs NK cell function indirectly through cytokine dysregulation of infected target cells. Journal of Virology. 82: 7189-200. PMID 18417583 DOI: 10.1128/Jvi.01979-07  0.572
2007 Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE. Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. Journal of Molecular Biology. 374: 121-9. PMID 17920628 DOI: 10.1016/J.Jmb.2007.09.009  0.575
2007 Schaubert KL, Price DA, Frahm N, Li J, Ng HL, Joseph A, Paul E, Majumder B, Ayyavoo V, Gostick E, Adams S, Marincola FM, Sewell AK, Altfeld M, Brenchley JM, et al. Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope. Journal of Immunology (Baltimore, Md. : 1950). 178: 7756-66. PMID 17548613 DOI: 10.4049/Jimmunol.178.12.7756  0.516
2007 Majumder B, Venkatachari NJ, Schafer EA, Janket ML, Ayyavoo V. Dendritic cells infected with vpr-positive human immunodeficiency virus type 1 induce CD8+ T-cell apoptosis via upregulation of tumor necrosis factor alpha. Journal of Virology. 81: 7388-99. PMID 17475642 DOI: 10.1128/Jvi.00893-06  0.773
2007 Janket ML, DeRicco JS, Borowski L, Ayyavoo V. Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells. Virus Research. 126: 76-85. PMID 17349711 DOI: 10.1016/J.Virusres.2007.01.019  0.794
2007 Venkatachari NJ, Majumder B, Ayyavoo V. Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function. Virology. 358: 347-56. PMID 17023015 DOI: 10.1016/J.Virol.2006.08.030  0.649
2006 Cui J, Tungaturthi PK, Ayyavoo V, Ghafouri M, Ariga H, Khalili K, Srinivasan A, Amini S, Sawaya BE. The role of Vpr in the regulation of HIV-1 gene expression. Cell Cycle (Georgetown, Tex.). 5: 2626-38. PMID 17172832 DOI: 10.4161/Cc.5.22.3442  0.577
2006 Schafer EA, Venkatachari NJ, Ayyavoo V. Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR). Antiviral Research. 72: 224-32. PMID 16889838 DOI: 10.1016/J.Antiviral.2006.06.008  0.639
2006 Wheeler ED, Achim CL, Ayyavoo V. Immunodetection of human immunodeficiency virus type 1 (HIV-1) Vpr in brain tissue of HIV-1 encephalitic patients. Journal of Neurovirology. 12: 200-10. PMID 16877301 DOI: 10.1080/13550280600827377  0.599
2005 Miles MC, Janket ML, Wheeler ED, Chattopadhyay A, Majumder B, Dericco J, Schafer EA, Ayyavoo V. Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis. The Febs Journal. 272: 4091-102. PMID 16098192 DOI: 10.1111/J.1742-4658.2005.04821.X  0.732
2005 Majumder B, Janket ML, Schafer EA, Schaubert K, Huang XL, Kan-Mitchell J, Rinaldo CR, Ayyavoo V. Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape. Journal of Virology. 79: 7990-8003. PMID 15956545 DOI: 10.1128/Jvi.79.13.7990-8003.2005  0.779
2005 Thotala D, Schafer EA, Tungaturthi PK, Majumder B, Janket ML, Wagner M, Srinivasan A, Watkins S, Ayyavoo V. Corrigendum to “Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues in Vpr-mediated transactivation and virus replication” [Virology 328 (2004) 89–100] Virology. 332: 691. DOI: 10.1016/J.Virol.2004.12.020  0.775
2004 Thotala D, Schafer EA, Tungaturthi PK, Majumder B, Janket ML, Wagner M, Srinivasan A, Watkins S, Ayyavoo V. Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication. Virology. 328: 89-100. PMID 15380361 DOI: 10.1016/J.Virol.2004.07.013  0.762
2004 Tungaturthi PK, Sawaya BE, Ayyavoo V, Murali R, Srinivasan A. HIV-1 Vpr: genetic diversity and functional features from the perspective of structure. Dna and Cell Biology. 23: 207-22. PMID 15142378 DOI: 10.1089/104454904773819798  0.542
2004 Janket ML, Manickam P, Majumder B, Thotala D, Wagner M, Schafer EA, Collman RG, Srinivasan A, Ayyavoo V. Differential regulation of host cellular genes by HIV-1 viral protein R (Vpr): cDNA microarray analysis using isogenic virus. Biochemical and Biophysical Research Communications. 314: 1126-32. PMID 14751250 DOI: 10.1016/J.Bbrc.2004.01.008  0.781
2003 Majumder B, Gray B, McBurney S, Schaefer TM, Dentchev T, Mahalingam S, Reinhart TA, Ayyavoo V. Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine. Immunology Letters. 89: 207-14. PMID 14556980 DOI: 10.1016/S0165-2478(03)00141-X  0.47
2003 Tungaturthi PK, Sawaya BE, Singh SP, Tomkowicz B, Ayyavoo V, Khalili K, Collman RG, Amini S, Srinivasan A. Role of HIV-1 Vpr in AIDS pathogenesis: relevance and implications of intravirion, intracellular and free Vpr. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 57: 20-4. PMID 12642033 DOI: 10.1016/S0753-3322(02)00328-1  0.6
2002 Muthumani K, Bagarazzi M, Conway D, Hwang DS, Ayyavoo V, Zhang D, Manson K, Kim J, Boyer J, Weiner DB. Inclusion of Vpr accessory gene in a plasmid vaccine cocktail markedly reduces Nef vaccine effectiveness in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques. Journal of Medical Primatology. 31: 179-85. PMID 12390540 DOI: 10.1034/J.1600-0684.2002.02004.X  0.465
2002 Ayyavoo V, Muthumani K, Kudchodkar S, Zhang D, Ramanathan P, Dayes NS, Kim JJ, Sin JI, Montaner LJ, Weiner DB. HIV-1 viral protein R compromises cellular immune function in vivo. International Immunology. 14: 13-22. PMID 11751747 DOI: 10.1093/Intimm/14.1.13  0.412
2001 Vanitharani R, Mahalingam S, Rafaeli Y, Singh SP, Srinivasan A, Weiner DB, Ayyavoo V. HIV-1 Vpr transactivates LTR-directed expression through sequences present within -278 to -176 and increases virus replication in vitro. Virology. 289: 334-42. PMID 11689055 DOI: 10.1006/Viro.2001.1153  0.598
2001 Ramanathan MP, Ayyavoo V, Weiner DB. Choice of expression vector alters the localization of a human cellular protein. Dna and Cell Biology. 20: 101-5. PMID 11244567 DOI: 10.1089/104454901750070300  0.334
2000 Muthumani K, Montaner LJ, Ayyavoo V, Weiner DB. Vpr-GFP virion particle identifies HIV-infected targets and preserves HIV-1Vpr function in macrophages and T-cells. Dna and Cell Biology. 19: 179-88. PMID 10749170 DOI: 10.1089/104454900314564  0.544
2000 Ayyavoo V, Kudchodkar S, Ramanathan MP, Le P, Muthumani K, Megalai NM, Dentchev T, Santiago-Barrios L, Mrinalini C, Weiner DB. Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes. Aids (London, England). 14: 1-9. PMID 10714562 DOI: 10.1097/00002030-200001070-00001  0.399
1998 Ayyavoo V, Nagashunmugam T, Phung MT, Buckner C, Kudckodkar S, Le P, Reddy PJ, Santiago L, Patel M, Tea L, Weiner DB. Construction of attenuated HIV-1 accessory gene immunization cassettes. Vaccine. 16: 1872-9. PMID 9795395 DOI: 10.1016/S0264-410X(98)00172-8  0.373
1998 Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 95: 3419-24. PMID 9520381 DOI: 10.1073/Pnas.95.7.3419  0.49
1998 Bagarazzi ML, Boyer JD, Ayyavoo V, Weiner DB. Nucleic acid-based vaccines as an approach to immunization against human immunodeficiency virus type-1. Current Topics in Microbiology and Immunology. 226: 107-43. PMID 9479839 DOI: 10.1007/978-3-642-80475-5_8  0.438
1997 Ayyavoo V, Nagashunmugam T, Boyer J, Mahalingam S, Fernandes LS, Le P, Lin J, Nguyen C, Chattargoon M, Goedert JJ, Friedman H, Weiner DB. Development of genetic vaccines for pathogenic genes: construction of attenuated vif DNA immunization cassettes. Aids (London, England). 11: 1433-44. PMID 9342065 DOI: 10.1097/00002030-199712000-00007  0.5
1997 Ayyavoo V, Mahboubi A, Mahalingam S, Ramalingam R, Kudchodkar S, Williams WV, Green DR, Weiner DB. HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B. Nature Medicine. 3: 1117-23. PMID 9334723 DOI: 10.1038/Nm1097-1117  0.395
1997 Ayyavoo V, Rafaeli Y, Nagashunmugam T, Mahalingham S, Phung MT, Hamam A, Williams WV, Weiner DB. HIV-1 viral protein R (Vpr) as a regulator of the target cell. Psychoneuroendocrinology. 22: S41-9. PMID 9264146 DOI: 10.1016/S0306-4530(97)00018-8  0.582
1997 Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Weiner DB. Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr. Journal of Virology. 71: 6339-47. PMID 9261351 DOI: 10.1128/Jvi.71.9.6339-6347.1997  0.356
1997 Kim JJ, Ayyavoo V, Bagarazzi ML, Chattergoon M, Boyer JD, Wang B, Weiner DB. Development of a multicomponent candidate vaccine for HIV-1. Vaccine. 15: 879-83. PMID 9234538 DOI: 10.1016/S0264-410X(96)00260-5  0.35
1997 Ayyavoo V, Mahalingam S, Rafaeli Y, Kudchodkar S, Chang D, Nagashunmugam T, Williams WV, Weiner DB. HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitro. Journal of Leukocyte Biology. 62: 93-9. PMID 9225999 DOI: 10.1002/Jlb.62.1.93  0.587
1997 Mahalingam S, MacDonald B, Ugen KE, Ayyavoo V, Agadjanyan MG, Williams WV, Weiner DB. In vitro and in vivo tumor growth suppression by HIV-1 Vpr. Dna and Cell Biology. 16: 137-43. PMID 9052734 DOI: 10.1089/Dna.1997.16.137  0.365
1997 Kim JJ, Ayyavoo V, Bagarazzi ML, Chattergoon MA, Dang K, Wang B, Boyer JD, Weiner DB. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. Journal of Immunology (Baltimore, Md. : 1950). 158: 816-26. PMID 8992999 DOI: 10.1016/S0165-2478(97)85079-1  0.433
1996 Ayyavoo V, Ugen KE, Fernandes LS, Goedert JJ, Rubinstein A, Williams WV, Weiner DB. Analysis of genetic heterogeneity, antigenicity, and biological characteristics of HIV-1 in a maternal transmitter and nontransmitter patient pair. Dna and Cell Biology. 15: 571-80. PMID 8756338 DOI: 10.1089/Dna.1996.15.571  0.448
1994 Ugen KE, Wang B, Ayyavoo V, Agadjanyan M, Boyer J, Li F, Kudchodkar S, Lin J, Merva M, Fernandes L, Williams WV, Weiner DB. DNA inoculation as a novel vaccination method against human retroviruses with rheumatic disease associations Immunologic Research. 13: 154-162. PMID 7775806 DOI: 10.1007/Bf02918276  0.395
1991 Ho WZ, Ayyavoo V, Srinivasan A, Stinski MF, Plotkin SA, Gonczol E. Human immunodeficiency virus type 1 tat gene enhances human cytomegalovirus gene expression and viral replication Aids Research and Human Retroviruses. 7: 689-695. PMID 1657075  0.518
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