| Year |
Citation |
Score |
| 2023 |
Johnston SN, Tsingas M, Ain R, Barve RA, Risbud MV. Increased HIF-2α Activity in the Nucleus Pulposus Causes Intervertebral Disc Degeneration in the Aging Mouse Spine. Biorxiv : the Preprint Server For Biology. PMID 38187709 DOI: 10.1101/2023.12.22.573086 |
0.338 |
|
| 2022 |
Johnston SN, Madhu V, Shapiro IM, Risbud MV. Conditional deletion of HIF-2α in mouse nucleus pulposus reduces fibrosis and provides mild and transient protection from age-dependent structural changes in intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 36117450 DOI: 10.1002/jbmr.4707 |
0.324 |
|
| 2020 |
Ohnishi T, Novais EJ, Risbud MV. Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration. Matrix Biology Plus. 6: 100036. PMID 33543030 DOI: 10.1016/j.mbplus.2020.100036 |
0.325 |
|
| 2020 |
Tsingas M, Ottone OK, Haseeb A, Barve RA, Shapiro IM, Lefebvre V, Risbud MV. Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 33027692 DOI: 10.1016/j.matbio.2020.09.003 |
0.339 |
|
| 2020 |
Tessier S, Risbud MV. Understanding embryonic development for cell-based therapies of intervertebral disc degeneration: Towards an effort to treat disc degeneration subphenotypes. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 32564440 DOI: 10.1002/Dvdy.217 |
0.35 |
|
| 2020 |
Novais EJ, Tran VA, Miao J, Slaver K, Sinensky A, Dyment NA, Addya S, Szeri F, van de Wetering K, Shapiro IM, Risbud MV. Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging. Aging Cell. PMID 32319726 DOI: 10.1111/Acel.13148 |
0.33 |
|
| 2020 |
Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, Shapiro IM, Risbud MV. Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1α -BNIP3 axis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 32251541 DOI: 10.1002/Jbmr.4019 |
0.394 |
|
| 2020 |
Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO, Risbud MV. Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. Jci Insight. PMID 31961823 DOI: 10.1172/Jci.Insight.131382 |
0.369 |
|
| 2019 |
Gorth DJ, Ottone OK, Shapiro IM, Risbud MV. Differential effect of long-term systemic exposure of TNFα on health of the annulus fibrosus and nucleus pulposus of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31800975 DOI: 10.1002/Jbmr.3931 |
0.406 |
|
| 2019 |
Tessier S, Tran VA, Ottone OK, Novais EJ, Doolittle A, DiMuzio MJ, Shapiro IM, Risbud MV. TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31707045 DOI: 10.1016/J.Matbio.2019.10.007 |
0.395 |
|
| 2019 |
Silagi ES, Novais EJ, Bisetto S, Telonis AG, Snuggs J, Le Maitre CL, Qiu Y, Kurland IJ, Shapiro IM, Philp NJ, Risbud MV. Lactate Efflux from Intervertebral Disc Cells is Required for Maintenance of Spine Health. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31692093 DOI: 10.1002/Jbmr.3908 |
0.316 |
|
| 2019 |
Choi H, Madhu V, Shapiro IM, Risbud MV. Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation. Scientific Reports. 9: 15469. PMID 31664118 DOI: 10.1038/S41598-019-51939-7 |
0.402 |
|
| 2019 |
Tessier S, Madhu V, Johnson ZI, Shapiro IM, Risbud MV. NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis. Developmental Biology. PMID 31301300 DOI: 10.1016/J.Ydbio.2019.07.004 |
0.456 |
|
| 2019 |
Gorth DJ, Shapiro IM, Risbud MV. A new understanding of the role of IL-1 in age-related intervertebral disc degeneration in a murine model. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 30875127 DOI: 10.1002/Jbmr.3714 |
0.323 |
|
| 2019 |
Novais EM, Diekman BO, Shapiro IM, Risbud MV. p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 30811968 DOI: 10.1016/J.Matbio.2019.02.004 |
0.404 |
|
| 2018 |
Gorth DJ, Shapiro IM, Risbud MV. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death & Disease. 10: 7. PMID 30584238 DOI: 10.1038/S41419-018-1246-X |
0.422 |
|
| 2018 |
Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 30092282 DOI: 10.1016/J.Matbio.2018.08.003 |
0.482 |
|
| 2018 |
Choi H, Chaiyamongkol W, Doolittle AC, Johnson ZI, Gogate SS, Schoepflin ZR, Shapiro IM, Risbud MV. COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus Cells. The Journal of Biological Chemistry. PMID 29700115 DOI: 10.1074/Jbc.Ra117.001167 |
0.47 |
|
| 2018 |
Choi H, Tessier S, Silagi ES, Kyada R, Yousefi F, Pleshko N, Shapiro IM, Risbud MV. A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29605718 DOI: 10.1016/J.Matbio.2018.03.019 |
0.387 |
|
| 2018 |
Silagi ES, Batista P, Shapiro IM, Risbud MV. Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Scientific Reports. 8: 4856. PMID 29559661 DOI: 10.1038/S41598-018-23196-7 |
0.435 |
|
| 2018 |
Silagi ES, Shapiro IM, Risbud MV. Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29501510 DOI: 10.1016/J.Matbio.2018.02.025 |
0.35 |
|
| 2017 |
Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. Bicarbonate Recycling by HIF-1-dependent Carbonic Anhydrase isoforms 9 and 12 is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28940640 DOI: 10.1002/Jbmr.3293 |
0.387 |
|
| 2017 |
Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV. TNF-α Promotes Nuclear Enrichment of TonEBP/NFAT5 to Selectively Control Inflammatory but not Osmoregulatory Responses in Nucleus Pulposus Cells. The Journal of Biological Chemistry. PMID 28842479 DOI: 10.1074/Jbc.M117.790378 |
0.436 |
|
| 2017 |
Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV. Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Scientific Reports. 7: 4543. PMID 28674405 DOI: 10.1038/S41598-017-04876-2 |
0.399 |
|
| 2017 |
Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28495754 DOI: 10.1096/Fj.201601291R |
0.461 |
|
| 2016 |
Johnson ZI, Shapiro IM, Risbud MV. RNA sequencing reveals a role of TonEBP in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells: A homeostatic response? The Journal of Biological Chemistry. PMID 27875309 DOI: 10.1074/Jbc.M116.757732 |
0.432 |
|
| 2016 |
Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 0. PMID 27314664 DOI: 10.1080/15548627.2016.1192753 |
0.42 |
|
| 2016 |
Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Scientific Reports. 6: 28038. PMID 27292569 DOI: 10.1038/Srep28038 |
0.428 |
|
| 2016 |
Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. PMID 27049729 DOI: 10.18632/Oncotarget.8521 |
0.476 |
|
| 2016 |
Binch AL, Shapiro IM, Risbud MV. Syndecan-4 in intervertebral disc and cartilage: Saint or synner? Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26796346 DOI: 10.1016/J.Matbio.2016.01.005 |
0.411 |
|
| 2016 |
Schoepflin ZR, Shapiro IM, Risbud MV. Class I and IIa HDACs Mediate HIF-1α Stability through PHD2-Dependent Mechanism while HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26765925 DOI: 10.1002/Jbmr.2787 |
0.433 |
|
| 2015 |
Tian Y, Yuan W, Li J, Wang H, Hunt MG, Liu C, Shapiro IM, Risbud MV. TGFβ regulates galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: Implications in intervertebral disc degeneration. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26639428 DOI: 10.1016/J.Matbio.2015.11.008 |
0.513 |
|
| 2015 |
Johnson ZI, Schoepflin ZR, Choi H, Shapiro IM, Risbud MV. Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration. European Cells & Materials. 30: 104-16; discussion 1. PMID 26388614 DOI: 10.22203/Ecm.V030A08 |
0.391 |
|
| 2015 |
Blanco FF, Jimbo M, Wulfkuhle J, Gallagher I, Deng J, Enyenihi L, Meisner-Kober N, Londin E, Rigoutsos I, Sawicki JA, Risbud MV, Witkiewicz AK, McCue PA, Jiang W, Rui H, et al. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene. PMID 26387536 DOI: 10.1038/Onc.2015.325 |
0.4 |
|
| 2015 |
Shapiro IM, Landis WJ, Risbud MV. Matrix vesicles: Are they anchored exosomes? Bone. 79: 29-36. PMID 25980744 DOI: 10.1016/J.Bone.2015.05.013 |
0.357 |
|
| 2015 |
Kepler CK, Markova DZ, Koerner JD, Mendelis J, Chen CM, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Substance P Receptor Antagonist Suppresses Inflammatory Cytokine Expression in Human Disc Cells. Spine. PMID 25929203 DOI: 10.1097/Brs.0000000000000954 |
0.331 |
|
| 2015 |
Johnson ZI, Gogate SS, Day R, Binch A, Markova DZ, Chiverton N, Cole A, Conner M, Shapiro IM, Le Maitre CL, Risbud MV. Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells. Oncotarget. 6: 11945-58. PMID 25844601 DOI: 10.18632/Oncotarget.3631 |
0.498 |
|
| 2015 |
Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. The Journal of Biological Chemistry. 290: 7195-207. PMID 25635047 DOI: 10.1074/Jbc.M114.611483 |
0.457 |
|
| 2015 |
Choi H, Johnson ZI, Risbud MV. Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Current Stem Cell Research & Therapy. 10: 307-16. PMID 25584906 DOI: 10.2174/1574888X10666150113112149 |
0.386 |
|
| 2015 |
Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV. Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. The American Journal of Pathology. 185: 485-95. PMID 25476526 DOI: 10.1016/J.Ajpath.2014.09.021 |
0.431 |
|
| 2015 |
Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA. Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 283-93. PMID 25411088 DOI: 10.1002/Jor.22789 |
0.375 |
|
| 2015 |
Blanco FF, Meisner-Kober NC, Londin E, Rigoutsos I, Risbud MV, Yeo CJ, Winter JM, Brody JR. Abstract A05: The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through post-transcriptional regulation of the serine-threonine kinase PIM1 Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Pms14-A05 |
0.393 |
|
| 2014 |
Koerner JD, Markova DZ, Yadla S, Mendelis J, Hilibrand A, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG, Kepler CK. Differential gene expression in anterior and posterior annulus fibrosus. Spine. 39: 1917-23. PMID 25365709 DOI: 10.1097/Brs.0000000000000590 |
0.395 |
|
| 2014 |
Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. Plos One. 9: e110768. PMID 25338007 DOI: 10.1371/Journal.Pone.0110768 |
0.431 |
|
| 2014 |
Johnson ZI, Shapiro IM, Risbud MV. Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Matrix Biology : Journal of the International Society For Matrix Biology. 40: 10-6. PMID 25172826 DOI: 10.1016/J.Matbio.2014.08.014 |
0.461 |
|
| 2014 |
Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc disease. The American Journal of Pathology. 184: 2560-72. PMID 25063530 DOI: 10.1016/J.Ajpath.2014.06.006 |
0.424 |
|
| 2014 |
Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. The Journal of Biological Chemistry. 289: 20594-605. PMID 24867948 DOI: 10.1074/Jbc.M114.565101 |
0.489 |
|
| 2014 |
Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2455-65. PMID 24558194 DOI: 10.1096/Fj.13-243741 |
0.791 |
|
| 2014 |
Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. The Journal of Biological Chemistry. 289: 7374-87. PMID 24464580 DOI: 10.1074/Jbc.M113.526111 |
0.765 |
|
| 2014 |
Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nature Reviews. Rheumatology. 10: 44-56. PMID 24166242 DOI: 10.1038/Nrrheum.2013.160 |
0.385 |
|
| 2014 |
Gogate S, Johnson Z, Day R, Binch A, Markova D, Chiverton N, Cole A, Conner M, Shapiro I, Maitre CLL, Risbud M. Unique Regulation of AQP1 and AQP5 Expression by HIF-1 in Nucleus Pulposus Cells Global Spine Journal. 4. DOI: 10.1055/S-0034-1376558 |
0.446 |
|
| 2014 |
Risbud MV, Shapiro IM. Microenvironmental control of disc cell function: Influence of hypoxia and osmotic pressure The Intervertebral Disc: Molecular and Structural Studies of the Disc in Health and Disease. 93-108. DOI: 10.1007/978-3-7091-1535-0_6 |
0.402 |
|
| 2013 |
Kepler CK, Markova DZ, Dibra F, Yadla S, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs. Spine. 38: 873-80. PMID 23660804 DOI: 10.1097/Brs.0B013E318285Ae08 |
0.304 |
|
| 2013 |
Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. The American Journal of Pathology. 182: 2310-21. PMID 23602832 DOI: 10.1016/J.Ajpath.2013.02.037 |
0.497 |
|
| 2013 |
Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. The Journal of Biological Chemistry. 288: 16761-74. PMID 23589286 DOI: 10.1074/Jbc.M112.446633 |
0.496 |
|
| 2013 |
Tran CM, Shapiro IM, Risbud MV. Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues. Matrix Biology : Journal of the International Society For Matrix Biology. 32: 298-306. PMID 23567513 DOI: 10.1016/J.Matbio.2013.03.006 |
0.76 |
|
| 2013 |
Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity. The Journal of Biological Chemistry. 288: 12654-66. PMID 23530034 DOI: 10.1074/Jbc.M112.448860 |
0.791 |
|
| 2013 |
Wang J, Tian Y, Phillips KL, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL, Risbud MV. Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthritis and Rheumatism. 65: 832-42. PMID 23233369 DOI: 10.1002/Art.37819 |
0.453 |
|
| 2012 |
Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, Alini M, Risbud MV, Chan D, Cheah KS, Yamamura K, Masuda K, Okano H, Ando K, Mochida J. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nature Communications. 3: 1264. PMID 23232394 DOI: 10.1038/Ncomms2226 |
0.336 |
|
| 2012 |
Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling. The Journal of Biological Chemistry. 287: 39942-53. PMID 22948157 DOI: 10.1074/Jbc.M112.375964 |
0.497 |
|
| 2012 |
Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Arthritis and Rheumatism. 64: 3324-33. PMID 22674034 DOI: 10.1002/Art.34570 |
0.49 |
|
| 2012 |
Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia. The Journal of Biological Chemistry. 287: 16975-86. PMID 22451659 DOI: 10.1074/Jbc.M111.334466 |
0.463 |
|
| 2012 |
Gogate SS, Fujita N, Skubutyte R, Shapiro IM, Risbud MV. Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1α degradation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 1106-17. PMID 22322648 DOI: 10.1002/Jbmr.1571 |
0.411 |
|
| 2012 |
Fujita N, Chiba K, Shapiro IM, Risbud MV. HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 401-12. PMID 21987385 DOI: 10.1002/Jbmr.538 |
0.398 |
|
| 2011 |
Risbud MV, Shapiro IM. Notochordal cells in the adult intervertebral disc: new perspective on an old question. Critical Reviews in Eukaryotic Gene Expression. 21: 29-41. PMID 21967331 DOI: 10.1615/Critreveukargeneexpr.V21.I1.30 |
0.449 |
|
| 2011 |
Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV. TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. The Journal of Biological Chemistry. 286: 39738-49. PMID 21949132 DOI: 10.1074/Jbc.M111.264549 |
0.47 |
|
| 2011 |
Tran CM, Smith HE, Symes A, Rittié L, Perbal B, Shapiro IM, Risbud MV. Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Arthritis and Rheumatism. 63: 3022-31. PMID 21618206 DOI: 10.1002/Art.30468 |
0.767 |
|
| 2011 |
Gogate SS, Nasser R, Shapiro IM, Risbud MV. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Arthritis and Rheumatism. 63: 1950-60. PMID 21400481 DOI: 10.1002/Art.30342 |
0.474 |
|
| 2011 |
Hiyama A, Skubutyte R, Markova D, Anderson DG, Yadla S, Sakai D, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis and Rheumatism. 63: 1355-64. PMID 21305512 DOI: 10.1002/Art.30246 |
0.365 |
|
| 2010 |
Risbud MV, Schaer TP, Shapiro IM. Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 2141-8. PMID 20568241 DOI: 10.1002/Dvdy.22350 |
0.366 |
|
| 2010 |
Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, Abe K, Mochida J. Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression. Arthritis and Rheumatism. 62: 3036-47. PMID 20533544 DOI: 10.1002/Art.27599 |
0.412 |
|
| 2010 |
Shapiro IM, Risbud MV. Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Research & Therapy. 12: 117. PMID 20497604 DOI: 10.1186/Ar3003 |
0.368 |
|
| 2010 |
Skubutyte R, Markova D, Freeman TA, Anderson DG, Dion AS, Williams CJ, Shapiro IM, Risbud MV. Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc. Arthritis and Rheumatism. 62: 2707-15. PMID 20496369 DOI: 10.1002/Art.27558 |
0.497 |
|
| 2010 |
Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV. Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis and Rheumatism. 62: 1983-92. PMID 20222112 DOI: 10.1002/Art.27445 |
0.775 |
|
| 2010 |
Risbud MV, Schipani E, Shapiro IM. Hypoxic regulation of nucleus pulposus cell survival: from niche to notch. The American Journal of Pathology. 176: 1577-83. PMID 20133815 DOI: 10.2353/Ajpath.2010.090734 |
0.439 |
|
| 2010 |
Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 1179-90. PMID 19961337 DOI: 10.1359/Jbmr.091202 |
0.393 |
|
| 2010 |
Saraiya M, Nasser R, Zeng Y, Addya S, Ponnappan RK, Fortina P, Anderson DG, Albert TJ, Shapiro IM, Risbud MV. Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells. Tissue Engineering. Part A. 16: 1443-55. PMID 19947906 DOI: 10.1089/Ten.Tea.2009.0343 |
0.441 |
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| 2009 |
Cheng CC, Uchiyama Y, Hiyama A, Gajghate S, Shapiro IM, Risbud MV. PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. Journal of Cellular Physiology. 221: 668-76. PMID 19711351 DOI: 10.1002/Jcp.21904 |
0.449 |
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| 2009 |
Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV. Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. The Journal of Biological Chemistry. 284: 9824-34. PMID 19147493 DOI: 10.1074/Jbc.M807081200 |
0.456 |
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| 2009 |
Gajghate S, Hiyama A, Shah M, Sakai D, Anderson DG, Shapiro IM, Risbud MV. Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 992-1001. PMID 19138132 DOI: 10.1359/Jbmr.090103 |
0.43 |
|
| 2008 |
Agrawal A, Gajghate S, Smith H, Anderson DG, Albert TJ, Shapiro IM, Risbud MV. Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc. Arthritis and Rheumatism. 58: 3798-808. PMID 19035510 DOI: 10.1002/Art.24073 |
0.382 |
|
| 2008 |
Uchiyama Y, Guttapalli A, Gajghate S, Mochida J, Shapiro IM, Risbud MV. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 23: 1619-28. PMID 18466073 DOI: 10.1359/Jbmr.080502 |
0.481 |
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| 2007 |
Risbud MV, Guttapalli A, Tsai TT, Lee JY, Danielson KG, Vaccaro AR, Albert TJ, Gazit Z, Gazit D, Shapiro IM. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine. 32: 2537-44. PMID 17978651 DOI: 10.1097/Brs.0B013E318158Dea6 |
0.335 |
|
| 2007 |
Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1996-2006. PMID 17696763 DOI: 10.1359/Jbmr.070805 |
0.425 |
|
| 2007 |
Zeng Y, Danielson KG, Albert TJ, Shapiro IM, Risbud MV. HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1851-61. PMID 17592963 DOI: 10.1359/Jbmr.070620 |
0.38 |
|
| 2007 |
Bucaro MA, Zahm AM, Risbud MV, Ayyaswamy PS, Mukundakrishnan K, Steinbeck MJ, Shapiro IM, Adams CS. The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis. Journal of Cellular Biochemistry. 102: 483-95. PMID 17520667 DOI: 10.1002/Jcb.21310 |
0.367 |
|
| 2007 |
Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. American Journal of Physiology. Cell Physiology. 293: C621-31. PMID 17442734 DOI: 10.1152/Ajpcell.00538.2006 |
0.413 |
|
| 2007 |
Tsai TT, Guttapalli A, Agrawal A, Albert TJ, Shapiro IM, Risbud MV. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 965-74. PMID 17371162 DOI: 10.1359/Jbmr.070322 |
0.44 |
|
| 2007 |
Tsai TT, Guttapalli A, Oguz E, Chen LH, Vaccaro AR, Albert TJ, Shapiro IM, Risbud MV. Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy. Spine. 32: 495-502. PMID 17334282 DOI: 10.1097/01.Brs.0000257341.88880.F1 |
0.373 |
|
| 2007 |
Oguz E, Tsai TT, Di Martino A, Guttapalli A, Albert TJ, Shapiro IM, Risbud MV. Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype? Spine. 32: 9-16. PMID 17202886 DOI: 10.1097/01.Brs.0000250302.74574.98 |
0.303 |
|
| 2006 |
Tsai TT, Danielson KG, Guttapalli A, Oguz E, Albert TJ, Shapiro IM, Risbud MV. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. The Journal of Biological Chemistry. 281: 25416-24. PMID 16772300 DOI: 10.1074/Jbc.M601969200 |
0.444 |
|
| 2006 |
Risbud MV, Guttapalli A, Stokes DG, Hawkins D, Danielson KG, Schaer TP, Albert TJ, Shapiro IM. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. Journal of Cellular Biochemistry. 98: 152-9. PMID 16408279 DOI: 10.1002/Jcb.20765 |
0.395 |
|
| 2005 |
Risbud MV, Guttapalli A, Albert TJ, Shapiro IM. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Spine. 30: 2503-9. PMID 16284587 DOI: 10.1097/01.Brs.0000186326.82747.13 |
0.432 |
|
| 2005 |
Anderson DG, Albert TJ, Fraser JK, Risbud M, Wuisman P, Meisel HJ, Tannoury C, Shapiro I, Vaccaro AR. Cellular therapy for disc degeneration. Spine. 30: S14-9. PMID 16138059 DOI: 10.1097/01.Brs.0000175174.50235.Ba |
0.34 |
|
| 2005 |
Di Martino A, Sittinger M, Risbud MV. Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials. 26: 5983-90. PMID 15894370 DOI: 10.1016/J.Biomaterials.2005.03.016 |
0.318 |
|
| 2005 |
Risbud MV, Fertala J, Vresilovic EJ, Albert TJ, Shapiro IM. Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine. 30: 882-9. PMID 15834331 DOI: 10.1097/01.Brs.0000159096.11248.6D |
0.324 |
|
| 2004 |
Bucaro MA, Fertala J, Adams CS, Steinbeck M, Ayyaswamy P, Mukundakrishnan K, Shapiro IM, Risbud MV. Bone cell survival in microgravity: evidence that modeled microgravity increases osteoblast sensitivity to apoptogens. Annals of the New York Academy of Sciences. 1027: 64-73. PMID 15644346 DOI: 10.1196/Annals.1324.007 |
0.366 |
|
| 2004 |
Risbud MV, Albert TJ, Guttapalli A, Vresilovic EJ, Hillibrand AS, Vaccaro AR, Shapiro IM. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine. 29: 2627-32. PMID 15564911 DOI: 10.1097/01.Brs.0000146462.92171.7F |
0.325 |
|
| 2004 |
Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ. Stem cell regeneration of the nucleus pulposus. The Spine Journal : Official Journal of the North American Spine Society. 4: 348S-353S. PMID 15541688 DOI: 10.1016/J.Spinee.2004.07.031 |
0.36 |
|
| 2004 |
Sittinger M, Hutmacher DW, Risbud MV. Current strategies for cell delivery in cartilage and bone regeneration. Current Opinion in Biotechnology. 15: 411-8. PMID 15464370 DOI: 10.1016/J.Copbio.2004.08.010 |
0.338 |
|
| 2004 |
El-Ghannam AR, Ducheyne P, Risbud M, Adams CS, Shapiro IM, Castner D, Golledge S, Composto RJ. Model surfaces engineered with nanoscale roughness and RGD tripeptides promote osteoblast activity. Journal of Biomedical Materials Research. Part A. 68: 615-27. PMID 14986317 DOI: 10.1002/Jbm.A.20051 |
0.314 |
|
| 2003 |
Risbud MV, Karamuk E, Schlosser V, Mayer J. Hydrogel-coated textile scaffolds as candidate in liver tissue engineering: II. Evaluation of spheroid formation and viability of hepatocytes. Journal of Biomaterials Science. Polymer Edition. 14: 719-31. PMID 12903739 DOI: 10.1163/156856203322274969 |
0.34 |
|
| 2002 |
Risbud MV, Dabhade R, Gangal S, Bhonde RR. Radio-frequency plasma treatment improves the growth and attachment of endothelial cells on poly(methyl methacrylate) substrates: implications in tissue engineering. Journal of Biomaterials Science. Polymer Edition. 13: 1067-80. PMID 12484484 DOI: 10.1163/156856202320813792 |
0.315 |
|
| 2002 |
Risbud MV, Karamuk E, Moser R, Mayer J. Hydrogel-coated textile scaffolds as three-dimensional growth support for human umbilical vein endothelial cells (HUVECs): possibilities as coculture system in liver tissue engineering. Cell Transplantation. 11: 369-77. PMID 12162377 DOI: 10.3727/000000002783985837 |
0.358 |
|
| 2002 |
Risbud MV, Sittinger M. Tissue engineering: advances in in vitro cartilage generation. Trends in Biotechnology. 20: 351-6. PMID 12127283 DOI: 10.1016/S0167-7799(02)02016-4 |
0.309 |
|
| 2002 |
Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell and Tissue Research. 308: 401-7. PMID 12107433 DOI: 10.1007/S00441-002-0563-6 |
0.449 |
|
| 2002 |
Kurup S, Risbud MV, Bhonde RR. Selective cytotoxicity of MIA Pa Ca-2 conditioned medium to acinar cells: a novel approach to reduce acinar cell contaminants in isolated islet preparations from BALB/c mice. Transplant International : Official Journal of the European Society For Organ Transplantation. 14: 191-5. PMID 11499910 DOI: 10.1007/S001470100303 |
0.328 |
|
| 2002 |
Risbud MV, Bhonde MR, Bhonde RR. Effect of chitosan-polyvinyl pyrrolidone hydrogel on proliferation and cytokine expression of endothelial cells: implications in islet immunoisolation. Journal of Biomedical Materials Research. 57: 300-5. PMID 11484194 DOI: 10.1002/1097-4636(200111)57:2<300::Aid-Jbm1171>3.0.Co;2-Q |
0.442 |
|
| 2000 |
Risbud M, Hardikar A, Bhonde R. Growth modulation of fibroblasts by chitosan-polyvinyl pyrrolidone hydrogel: implications for wound management? Journal of Biosciences. 25: 25-31. PMID 10824195 DOI: 10.1007/Bf02985178 |
0.33 |
|
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