Year |
Citation |
Score |
2020 |
Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, Shapiro IM, Risbud MV. Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1α -BNIP3 axis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 32251541 DOI: 10.1002/Jbmr.4019 |
0.31 |
|
2020 |
Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO, Risbud MV. Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. Jci Insight. PMID 31961823 DOI: 10.1172/Jci.Insight.131382 |
0.328 |
|
2019 |
Gorth DJ, Ottone OK, Shapiro IM, Risbud MV. Differential effect of long-term systemic exposure of TNFα on health of the annulus fibrosus and nucleus pulposus of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31800975 DOI: 10.1002/Jbmr.3931 |
0.311 |
|
2019 |
Tessier S, Tran VA, Ottone OK, Novais EJ, Doolittle A, DiMuzio MJ, Shapiro IM, Risbud MV. TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31707045 DOI: 10.1016/J.Matbio.2019.10.007 |
0.344 |
|
2019 |
Silagi ES, Novais EJ, Bisetto S, Telonis AG, Snuggs J, Le Maitre CL, Qiu Y, Kurland IJ, Shapiro IM, Philp NJ, Risbud MV. Lactate Efflux from Intervertebral Disc Cells is Required for Maintenance of Spine Health. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31692093 DOI: 10.1002/Jbmr.3908 |
0.324 |
|
2019 |
Choi H, Madhu V, Shapiro IM, Risbud MV. Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation. Scientific Reports. 9: 15469. PMID 31664118 DOI: 10.1038/S41598-019-51939-7 |
0.325 |
|
2019 |
Tessier S, Madhu V, Johnson ZI, Shapiro IM, Risbud MV. NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis. Developmental Biology. PMID 31301300 DOI: 10.1016/J.Ydbio.2019.07.004 |
0.34 |
|
2019 |
Novais EM, Diekman BO, Shapiro IM, Risbud MV. p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 30811968 DOI: 10.1016/J.Matbio.2019.02.004 |
0.318 |
|
2018 |
Gorth DJ, Shapiro IM, Risbud MV. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death & Disease. 10: 7. PMID 30584238 DOI: 10.1038/S41419-018-1246-X |
0.323 |
|
2018 |
Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 30092282 DOI: 10.1016/J.Matbio.2018.08.003 |
0.361 |
|
2018 |
Choi H, Chaiyamongkol W, Doolittle AC, Johnson ZI, Gogate SS, Schoepflin ZR, Shapiro IM, Risbud MV. COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus Cells. The Journal of Biological Chemistry. PMID 29700115 DOI: 10.1074/Jbc.Ra117.001167 |
0.359 |
|
2018 |
Choi H, Tessier S, Silagi ES, Kyada R, Yousefi F, Pleshko N, Shapiro IM, Risbud MV. A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29605718 DOI: 10.1016/J.Matbio.2018.03.019 |
0.322 |
|
2018 |
Silagi ES, Batista P, Shapiro IM, Risbud MV. Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Scientific Reports. 8: 4856. PMID 29559661 DOI: 10.1038/S41598-018-23196-7 |
0.319 |
|
2018 |
Silagi ES, Shapiro IM, Risbud MV. Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29501510 DOI: 10.1016/J.Matbio.2018.02.025 |
0.302 |
|
2017 |
Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. Bicarbonate Recycling by HIF-1-dependent Carbonic Anhydrase isoforms 9 and 12 is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28940640 DOI: 10.1002/Jbmr.3293 |
0.313 |
|
2017 |
Hickok NJ, Shapiro IM, Chen AF. The Impact of Incorporating Antimicrobials into Implant Surfaces. Journal of Dental Research. 22034517731768. PMID 28922615 DOI: 10.1177/0022034517731768 |
0.309 |
|
2017 |
Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV. TNF-α Promotes Nuclear Enrichment of TonEBP/NFAT5 to Selectively Control Inflammatory but not Osmoregulatory Responses in Nucleus Pulposus Cells. The Journal of Biological Chemistry. PMID 28842479 DOI: 10.1074/Jbc.M117.790378 |
0.3 |
|
2017 |
Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV. Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Scientific Reports. 7: 4543. PMID 28674405 DOI: 10.1038/S41598-017-04876-2 |
0.315 |
|
2017 |
Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28495754 DOI: 10.1096/Fj.201601291R |
0.313 |
|
2016 |
Johnson ZI, Shapiro IM, Risbud MV. RNA sequencing reveals a role of TonEBP in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells: A homeostatic response? The Journal of Biological Chemistry. PMID 27875309 DOI: 10.1074/Jbc.M116.757732 |
0.321 |
|
2016 |
Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 0. PMID 27314664 DOI: 10.1080/15548627.2016.1192753 |
0.329 |
|
2016 |
Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. PMID 27049729 DOI: 10.18632/Oncotarget.8521 |
0.363 |
|
2016 |
Binch AL, Shapiro IM, Risbud MV. Syndecan-4 in intervertebral disc and cartilage: Saint or synner? Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26796346 DOI: 10.1016/J.Matbio.2016.01.005 |
0.347 |
|
2016 |
Schoepflin ZR, Shapiro IM, Risbud MV. Class I and IIa HDACs Mediate HIF-1α Stability through PHD2-Dependent Mechanism while HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26765925 DOI: 10.1002/Jbmr.2787 |
0.312 |
|
2015 |
Tian Y, Yuan W, Li J, Wang H, Hunt MG, Liu C, Shapiro IM, Risbud MV. TGFβ regulates galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: Implications in intervertebral disc degeneration. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26639428 DOI: 10.1016/J.Matbio.2015.11.008 |
0.36 |
|
2015 |
Shapiro IM, Landis WJ, Risbud MV. Matrix vesicles: Are they anchored exosomes? Bone. 79: 29-36. PMID 25980744 DOI: 10.1016/J.Bone.2015.05.013 |
0.379 |
|
2015 |
Yang Y, Blair HC, Shapiro IM, Wang B. The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway. The Journal of Biological Chemistry. 290: 16918-28. PMID 25979341 DOI: 10.1074/Jbc.M115.663963 |
0.366 |
|
2015 |
Dastgheyb SS, Toorkey CB, Shapiro IM, Hickok NJ. Porphyrin-adsorbed Allograft Bone: A Photoactive, Antibiofilm Surface. Clinical Orthopaedics and Related Research. 473: 2865-73. PMID 25894811 DOI: 10.1007/S11999-015-4299-5 |
0.326 |
|
2015 |
Johnson ZI, Gogate SS, Day R, Binch A, Markova DZ, Chiverton N, Cole A, Conner M, Shapiro IM, Le Maitre CL, Risbud MV. Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells. Oncotarget. 6: 11945-58. PMID 25844601 DOI: 10.18632/Oncotarget.3631 |
0.336 |
|
2015 |
Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. The Journal of Biological Chemistry. 290: 7195-207. PMID 25635047 DOI: 10.1074/Jbc.M114.611483 |
0.319 |
|
2015 |
McIlhenny S, Zhang P, Tulenko T, Comeau J, Fernandez S, Policha A, Ferroni M, Faul E, Bagameri G, Shapiro I, DiMuzio P. eNOS transfection of adipose-derived stem cells yields bioactive nitric oxide production and improved results in vascular tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 9: 1277-85. PMID 23319464 DOI: 10.1002/Term.1645 |
0.335 |
|
2014 |
Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. Plos One. 9: e110768. PMID 25338007 DOI: 10.1371/Journal.Pone.0110768 |
0.315 |
|
2014 |
Johnson ZI, Shapiro IM, Risbud MV. Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Matrix Biology : Journal of the International Society For Matrix Biology. 40: 10-6. PMID 25172826 DOI: 10.1016/J.Matbio.2014.08.014 |
0.373 |
|
2014 |
Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc disease. The American Journal of Pathology. 184: 2560-72. PMID 25063530 DOI: 10.1016/J.Ajpath.2014.06.006 |
0.316 |
|
2014 |
Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. The Journal of Biological Chemistry. 289: 20594-605. PMID 24867948 DOI: 10.1074/Jbc.M114.565101 |
0.355 |
|
2014 |
Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2455-65. PMID 24558194 DOI: 10.1096/Fj.13-243741 |
0.352 |
|
2014 |
Diaz-Ledezma C, Parvizi J, Zhou Y, Antoci V, Ducheyne P, Freiberg A, Rangel GG, Han SB, Hickok N, Higuera C, Ketonis C, Korkusuz F, Kruczynski J, Macule F, Markuszewski J, ... ... Shapiro I, et al. Prosthesis selection. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 32: S90-7. PMID 24464902 DOI: 10.1002/jor.22552 |
0.425 |
|
2014 |
Diaz-Ledezma C, Parvizi J, Zhou Y, Antoci V, Ducheyne P, Freiberg A, Garcia Rangel G, Han SB, Hickok N, Higuera C, Ketonis C, Korkusuz F, Kruczynski J, Macule F, Markuszewski J, ... ... Shapiro I, et al. Prosthesis selection. The Journal of Arthroplasty. 29: 71-6. PMID 24360496 DOI: 10.1016/J.Arth.2013.09.039 |
0.483 |
|
2014 |
Shapiro IM, Layfield R, Lotz M, Settembre C, Whitehouse C. Boning up on autophagy: the role of autophagy in skeletal biology. Autophagy. 10: 7-19. PMID 24225636 DOI: 10.4161/Auto.26679 |
0.368 |
|
2014 |
Gogate S, Johnson Z, Day R, Binch A, Markova D, Chiverton N, Cole A, Conner M, Shapiro I, Maitre CLL, Risbud M. Unique Regulation of AQP1 and AQP5 Expression by HIF-1 in Nucleus Pulposus Cells Global Spine Journal. 4. DOI: 10.1055/S-0034-1376558 |
0.324 |
|
2013 |
Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. The American Journal of Pathology. 182: 2310-21. PMID 23602832 DOI: 10.1016/J.Ajpath.2013.02.037 |
0.32 |
|
2013 |
Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. The Journal of Biological Chemistry. 288: 16761-74. PMID 23589286 DOI: 10.1074/Jbc.M112.446633 |
0.33 |
|
2013 |
Tran CM, Shapiro IM, Risbud MV. Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues. Matrix Biology : Journal of the International Society For Matrix Biology. 32: 298-306. PMID 23567513 DOI: 10.1016/J.Matbio.2013.03.006 |
0.314 |
|
2013 |
Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity. The Journal of Biological Chemistry. 288: 12654-66. PMID 23530034 DOI: 10.1074/Jbc.M112.448860 |
0.355 |
|
2012 |
Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling. The Journal of Biological Chemistry. 287: 39942-53. PMID 22948157 DOI: 10.1074/Jbc.M112.375964 |
0.331 |
|
2012 |
Stewart S, Barr S, Engiles J, Hickok NJ, Shapiro IM, Richardson DW, Parvizi J, Schaer TP. Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in sheep: a proof-of-concept study. The Journal of Bone and Joint Surgery. American Volume. 94: 1406-15. PMID 22854994 DOI: 10.2106/Jbjs.K.00886 |
0.309 |
|
2012 |
Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Arthritis and Rheumatism. 64: 3324-33. PMID 22674034 DOI: 10.1002/Art.34570 |
0.321 |
|
2012 |
Liu Q, Limthongkul W, Sidhu G, Zhang J, Vaccaro A, Shenck R, Hickok N, Shapiro I, Freeman T. Covalent attachment of P15 peptide to titanium surfaces enhances cell attachment, spreading, and osteogenic gene expression. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 30: 1626-33. PMID 22504956 DOI: 10.1002/Jor.22116 |
0.402 |
|
2012 |
Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia. The Journal of Biological Chemistry. 287: 16975-86. PMID 22451659 DOI: 10.1074/Jbc.M111.334466 |
0.348 |
|
2012 |
Gogate SS, Fujita N, Skubutyte R, Shapiro IM, Risbud MV. Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1α degradation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 1106-17. PMID 22322648 DOI: 10.1002/Jbmr.1571 |
0.306 |
|
2011 |
Risbud MV, Shapiro IM. Notochordal cells in the adult intervertebral disc: new perspective on an old question. Critical Reviews in Eukaryotic Gene Expression. 21: 29-41. PMID 21967331 DOI: 10.1615/Critreveukargeneexpr.V21.I1.30 |
0.364 |
|
2011 |
Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV. TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. The Journal of Biological Chemistry. 286: 39738-49. PMID 21949132 DOI: 10.1074/Jbc.M111.264549 |
0.302 |
|
2011 |
Zahm AM, Bohensky J, Adams CS, Shapiro IM, Srinivas V. Bone cell autophagy is regulated by environmental factors. Cells, Tissues, Organs. 194: 274-8. PMID 21597271 DOI: 10.1159/000324647 |
0.386 |
|
2011 |
Gogate SS, Nasser R, Shapiro IM, Risbud MV. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Arthritis and Rheumatism. 63: 1950-60. PMID 21400481 DOI: 10.1002/Art.30342 |
0.315 |
|
2011 |
Ketonis C, Barr S, Adams CS, Shapiro IM, Parvizi J, Hickok NJ. Vancomycin bonded to bone grafts prevents bacterial colonization. Antimicrobial Agents and Chemotherapy. 55: 487-94. PMID 21098245 DOI: 10.1128/Aac.00741-10 |
0.329 |
|
2011 |
Ketonis C, Barr S, Shapiro IM, Parvizi J, Adams CS, Hickok NJ. Antibacterial activity of bone allografts: comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin. Bone. 48: 631-8. PMID 21035576 DOI: 10.1016/J.Bone.2010.10.171 |
0.363 |
|
2010 |
Zahm AM, Bucaro MA, Ayyaswamy PS, Srinivas V, Shapiro IM, Adams CS, Mukundakrishnan K. Numerical modeling of oxygen distributions in cortical and cancellous bone: oxygen availability governs osteonal and trabecular dimensions. American Journal of Physiology. Cell Physiology. 299: C922-9. PMID 20660162 DOI: 10.1152/Ajpcell.00465.2009 |
0.318 |
|
2010 |
Risbud MV, Schaer TP, Shapiro IM. Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 2141-8. PMID 20568241 DOI: 10.1002/Dvdy.22350 |
0.354 |
|
2010 |
Shapiro IM, Risbud MV. Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Research & Therapy. 12: 117. PMID 20497604 DOI: 10.1186/Ar3003 |
0.338 |
|
2010 |
Skubutyte R, Markova D, Freeman TA, Anderson DG, Dion AS, Williams CJ, Shapiro IM, Risbud MV. Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc. Arthritis and Rheumatism. 62: 2707-15. PMID 20496369 DOI: 10.1002/Art.27558 |
0.37 |
|
2010 |
Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV. Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis and Rheumatism. 62: 1983-92. PMID 20222112 DOI: 10.1002/Art.27445 |
0.336 |
|
2010 |
Risbud MV, Schipani E, Shapiro IM. Hypoxic regulation of nucleus pulposus cell survival: from niche to notch. The American Journal of Pathology. 176: 1577-83. PMID 20133815 DOI: 10.2353/Ajpath.2010.090734 |
0.349 |
|
2010 |
Ketonis C, Adams CS, Barr S, Aiyer A, Shapiro IM, Parvizi J, Hickok NJ. Antibiotic modification of native grafts: improving upon nature's scaffolds. Tissue Engineering. Part A. 16: 2041-9. PMID 20109017 DOI: 10.1089/Ten.Tea.2009.0610 |
0.331 |
|
2010 |
Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 1179-90. PMID 19961337 DOI: 10.1359/Jbmr.091202 |
0.312 |
|
2010 |
Saraiya M, Nasser R, Zeng Y, Addya S, Ponnappan RK, Fortina P, Anderson DG, Albert TJ, Shapiro IM, Risbud MV. Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells. Tissue Engineering. Part A. 16: 1443-55. PMID 19947906 DOI: 10.1089/Ten.Tea.2009.0343 |
0.412 |
|
2010 |
Bohensky J, Leshinsky S, Srinivas V, Shapiro IM. Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression. Pediatric Nephrology (Berlin, Germany). 25: 633-42. PMID 19830459 DOI: 10.1007/S00467-009-1310-Y |
0.324 |
|
2010 |
McIlhenny SE, Hager ES, Grabo DJ, DiMatteo C, Shapiro IM, Tulenko TN, DiMuzio PJ. Linear shear conditioning improves vascular graft retention of adipose-derived stem cells by upregulation of the alpha5beta1 integrin. Tissue Engineering. Part A. 16: 245-55. PMID 19698069 DOI: 10.1089/Ten.Tea.2009.0238 |
0.307 |
|
2009 |
Fischer LJ, McIlhenny S, Tulenko T, Golesorkhi N, Zhang P, Larson R, Lombardi J, Shapiro I, DiMuzio PJ. Endothelial differentiation of adipose-derived stem cells: effects of endothelial cell growth supplement and shear force. The Journal of Surgical Research. 152: 157-66. PMID 19883577 DOI: 10.1016/J.Jss.2008.06.029 |
0.313 |
|
2009 |
Cheng CC, Uchiyama Y, Hiyama A, Gajghate S, Shapiro IM, Risbud MV. PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. Journal of Cellular Physiology. 221: 668-76. PMID 19711351 DOI: 10.1002/Jcp.21904 |
0.353 |
|
2009 |
Denison TA, Koch CF, Shapiro IM, Schwartz Z, Boyan BD. Inorganic phosphate modulates responsiveness to 24,25(OH)2D3 in chondrogenic ATDC5 cells. Journal of Cellular Biochemistry. 107: 155-62. PMID 19288498 DOI: 10.1002/Jcb.22111 |
0.329 |
|
2009 |
Srinivas V, Bohensky J, Zahm AM, Shapiro IM. Autophagy in mineralizing tissues: microenvironmental perspectives. Cell Cycle (Georgetown, Tex.). 8: 391-3. PMID 19177014 DOI: 10.4161/Cc.8.3.7545 |
0.384 |
|
2009 |
Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV. Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. The Journal of Biological Chemistry. 284: 9824-34. PMID 19147493 DOI: 10.1074/Jbc.M807081200 |
0.373 |
|
2009 |
Gajghate S, Hiyama A, Shah M, Sakai D, Anderson DG, Shapiro IM, Risbud MV. Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 992-1001. PMID 19138132 DOI: 10.1359/Jbmr.090103 |
0.358 |
|
2009 |
Adams CS, Antoci V, Harrison G, Patal P, Freeman TA, Shapiro IM, Parvizi J, Hickok NJ, Radin S, Ducheyne P. Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 701-9. PMID 19051247 DOI: 10.1002/Jor.20815 |
0.553 |
|
2009 |
Freeman TA, Patel P, Parvizi J, Antoci V, Shapiro IM. Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healing. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 673-9. PMID 19016539 DOI: 10.1002/Jor.20771 |
0.317 |
|
2009 |
Toworfe GK, Bhattacharyya S, Composto RJ, Adams CS, Shapiro IM, Ducheyne P. Effect of functional end groups of silane self-assembled monolayer surfaces on apatite formation, fibronectin adsorption and osteoblast cell function. Journal of Tissue Engineering and Regenerative Medicine. 3: 26-36. PMID 19012271 DOI: 10.1002/Term.131 |
0.579 |
|
2009 |
Srinivas V, Bohensky J, Shapiro IM. Autophagy: a new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase. Cells, Tissues, Organs. 189: 88-92. PMID 18703865 DOI: 10.1159/000151428 |
0.324 |
|
2008 |
Antoci V, Adams CS, Parvizi J, Davidson HM, Composto RJ, Freeman TA, Wickstrom E, Ducheyne P, Jungkind D, Shapiro IM, Hickok NJ. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials. 29: 4684-90. PMID 18814909 DOI: 10.1016/J.Biomaterials.2008.08.016 |
0.538 |
|
2008 |
Zahm AM, Bucaro MA, Srinivas V, Shapiro IM, Adams CS. Oxygen tension regulates preosteocyte maturation and mineralization. Bone. 43: 25-31. PMID 18485858 DOI: 10.1016/J.Bone.2008.03.010 |
0.416 |
|
2008 |
Uchiyama Y, Guttapalli A, Gajghate S, Mochida J, Shapiro IM, Risbud MV. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 23: 1619-28. PMID 18466073 DOI: 10.1359/Jbmr.080502 |
0.371 |
|
2008 |
Watanabe H, Bohensky J, Freeman T, Srinivas V, Shapiro IM. Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy. Journal of Cellular Physiology. 216: 419-25. PMID 18288636 DOI: 10.1002/Jcp.21408 |
0.351 |
|
2007 |
Risbud MV, Guttapalli A, Tsai TT, Lee JY, Danielson KG, Vaccaro AR, Albert TJ, Gazit Z, Gazit D, Shapiro IM. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine. 32: 2537-44. PMID 17978651 DOI: 10.1097/Brs.0B013E318158Dea6 |
0.316 |
|
2007 |
Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1996-2006. PMID 17696763 DOI: 10.1359/Jbmr.070805 |
0.34 |
|
2007 |
Antoci V, Adams CS, Hickok NJ, Shapiro IM, Parvizi J. Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clinical Orthopaedics and Related Research. 462: 200-6. PMID 17572634 DOI: 10.1097/Blo.0B013E31811Ff866 |
0.354 |
|
2007 |
Antoci V, Adams CS, Parvizi J, Ducheyne P, Shapiro IM, Hickok NJ. Covalently attached vancomycin provides a nanoscale antibacterial surface. Clinical Orthopaedics and Related Research. 461: 81-7. PMID 17549031 DOI: 10.1097/Blo.0B013E3181123A50 |
0.57 |
|
2007 |
Bucaro MA, Zahm AM, Risbud MV, Ayyaswamy PS, Mukundakrishnan K, Steinbeck MJ, Shapiro IM, Adams CS. The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis. Journal of Cellular Biochemistry. 102: 483-95. PMID 17520667 DOI: 10.1002/Jcb.21310 |
0.375 |
|
2007 |
Silva GA, Coutinho OP, Ducheyne P, Shapiro IM, Reis RL. Starch-based microparticles as vehicles for the delivery of active platelet-derived growth factor. Tissue Engineering. 13: 1259-68. PMID 17518721 DOI: 10.1089/Ten.2006.0194 |
0.536 |
|
2007 |
Secchi AG, Grigoriou V, Shapiro IM, Cavalcanti-Adam EA, Composto RJ, Ducheyne P, Adams CS. RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis. Journal of Biomedical Materials Research. Part A. 83: 577-84. PMID 17503524 DOI: 10.1002/Jbm.A.31007 |
0.584 |
|
2007 |
Bohensky J, Shapiro IM, Leshinsky S, Watanabe H, Srinivas V. PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate. Journal of Cellular Physiology. 213: 246-51. PMID 17476689 DOI: 10.1002/Jcp.21117 |
0.361 |
|
2007 |
Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. American Journal of Physiology. Cell Physiology. 293: C621-31. PMID 17442734 DOI: 10.1152/Ajpcell.00538.2006 |
0.338 |
|
2007 |
Antoci V, King SB, Jose B, Parvizi J, Zeiger AR, Wickstrom E, Freeman TA, Composto RJ, Ducheyne P, Shapiro IM, Hickok NJ, Adams CS. Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 25: 858-66. PMID 17415753 DOI: 10.1002/Jor.20348 |
0.543 |
|
2007 |
Tsai TT, Guttapalli A, Agrawal A, Albert TJ, Shapiro IM, Risbud MV. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 965-74. PMID 17371162 DOI: 10.1359/Jbmr.070322 |
0.342 |
|
2007 |
Tsai TT, Guttapalli A, Oguz E, Chen LH, Vaccaro AR, Albert TJ, Shapiro IM, Risbud MV. Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy. Spine. 32: 495-502. PMID 17334282 DOI: 10.1097/01.Brs.0000257341.88880.F1 |
0.331 |
|
2007 |
Lee DC, Adams CS, Albert TJ, Shapiro IM, Evans SM, Koch CJ. In situ oxygen utilization in the rat intervertebral disc. Journal of Anatomy. 210: 294-303. PMID 17331178 DOI: 10.1111/J.1469-7580.2007.00692.X |
0.32 |
|
2007 |
Bohensky J, Shapiro IM, Leshinsky S, Terkhorn SP, Adams CS, Srinivas V. HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway. Autophagy. 3: 207-14. PMID 17224629 DOI: 10.4161/Auto.3708 |
0.352 |
|
2007 |
Pucci B, Adams CS, Fertala J, Snyder BC, Mansfield KD, Tafani M, Freeman T, Shapiro IM. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. Journal of Cellular Physiology. 210: 609-15. PMID 17133357 DOI: 10.1002/Jcp.20857 |
0.361 |
|
2007 |
Lee MH, Adams CS, Boettiger D, Degrado WF, Shapiro IM, Composto RJ, Ducheyne P. Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function. Journal of Biomedical Materials Research. Part A. 81: 150-60. PMID 17111408 DOI: 10.1002/Jbm.A.31065 |
0.541 |
|
2007 |
Terkhorn SP, Bohensky J, Shapiro IM, Koyama E, Srinivas V. Expression of HIF Prolyl Hydroxylase Isozymes in Growth Plate Chondrocytes: Relationship Between Maturation and Apoptotic Sensitivity Journal of Cellular Physiology. 210: 257-265. PMID 17044072 DOI: 10.1002/Jcp.20873 |
0.371 |
|
2007 |
Saunders R, Szymczyk KH, Shapiro IM, Adams CS. Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis. Journal of Cellular Biochemistry. 100: 703-15. PMID 17006955 DOI: 10.1002/Jcb.21001 |
0.307 |
|
2007 |
Silva GA, Coutinho OP, Ducheyne P, Shapiro IM, Reis RL. The effect of starch and starch-bioactive glass composite microparticles on the adhesion and expression of the osteoblastic phenotype of a bone cell line. Biomaterials. 28: 326-34. PMID 16876242 DOI: 10.1016/J.Biomaterials.2006.07.009 |
0.639 |
|
2007 |
Radin S, Antoci V, Hickok N, Adams CS, Parvizi J, Shapiro IM, Ducheyne P. In vitro and in vivo bactericidal effect of sol-gel/antibiotic thin films on fixation devices Key Engineering Materials. 1323-1326. DOI: 10.4028/Www.Scientific.Net/Kem.330-332.1323 |
0.528 |
|
2006 |
Srinivas V, Shapiro IM. Chondrocytes embedded in the epiphyseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis. Autophagy. 2: 215-6. PMID 16874108 DOI: 10.4161/Auto.2649 |
0.348 |
|
2006 |
Tsai TT, Danielson KG, Guttapalli A, Oguz E, Albert TJ, Shapiro IM, Risbud MV. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. The Journal of Biological Chemistry. 281: 25416-24. PMID 16772300 DOI: 10.1074/Jbc.M601969200 |
0.363 |
|
2006 |
Risbud MV, Guttapalli A, Stokes DG, Hawkins D, Danielson KG, Schaer TP, Albert TJ, Shapiro IM. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. Journal of Cellular Biochemistry. 98: 152-9. PMID 16408279 DOI: 10.1002/Jcb.20765 |
0.332 |
|
2006 |
Silva GA, Coutinho OP, Ducheyne P, Shapiro IM, Reis RL. Starch-Based Microparticles as a Novel Strategy for Tissue Engineering Applications Key Engineering Materials. 907-910. DOI: 10.4028/Www.Scientific.Net/Kem.309-311.907 |
0.578 |
|
2006 |
Toworfe GK, Composto RJ, Adams CS, Shapiro IM, Ducheyne P. Initial attachment of osteoblast-like cells on functionalized surfaces coated with calcium phosphate Key Engineering Materials. 309: 275-278. DOI: 10.4028/Www.Scientific.Net/Kem.309-311.275 |
0.567 |
|
2005 |
Shapiro IM, Adams CS, Freeman T, Srinivas V. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Research. Part C, Embryo Today : Reviews. 75: 330-9. PMID 16425255 DOI: 10.1002/Bdrc.20057 |
0.389 |
|
2005 |
Risbud MV, Guttapalli A, Albert TJ, Shapiro IM. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Spine. 30: 2503-9. PMID 16284587 DOI: 10.1097/01.Brs.0000186326.82747.13 |
0.347 |
|
2005 |
Smartt JM, Karmacharya J, Gannon FH, Teixeira C, Mansfield K, Hunenko O, Shapiro IM, Kirschner RE. Intrauterine fetal constraint induces chondrocyte apoptosis and premature ossification of the cranial base. Plastic and Reconstructive Surgery. 116: 1363-1369. PMID 16217480 DOI: 10.1097/01.Prs.0000182224.98761.Cf |
0.546 |
|
2005 |
Teixeira CC, Ischiropoulos H, Leboy PS, Adams SL, Shapiro IM. Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation. Bone. 37: 37-45. PMID 15869914 DOI: 10.1016/J.Bone.2005.03.010 |
0.346 |
|
2005 |
Risbud MV, Fertala J, Vresilovic EJ, Albert TJ, Shapiro IM. Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine. 30: 882-9. PMID 15834331 DOI: 10.1097/01.Brs.0000159096.11248.6D |
0.305 |
|
2005 |
Grigoriou V, Shapiro IM, Cavalcanti-Adam EA, Composto RJ, Ducheyne P, Adams CS. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. The Journal of Biological Chemistry. 280: 1733-9. PMID 15522882 DOI: 10.1074/Jbc.M402550200 |
0.59 |
|
2004 |
Mukundakrishnan K, Ayyaswamy PS, Risbud M, Hu HH, Shapiro IM. Modeling of phosphate ion transfer to the surface of osteoblasts under normal gravity and simulated microgravity conditions. Annals of the New York Academy of Sciences. 1027: 85-98. PMID 15644348 DOI: 10.1196/Annals.1324.009 |
0.328 |
|
2004 |
Bucaro MA, Fertala J, Adams CS, Steinbeck M, Ayyaswamy P, Mukundakrishnan K, Shapiro IM, Risbud MV. Bone cell survival in microgravity: evidence that modeled microgravity increases osteoblast sensitivity to apoptogens. Annals of the New York Academy of Sciences. 1027: 64-73. PMID 15644346 DOI: 10.1196/Annals.1324.007 |
0.398 |
|
2004 |
Risbud MV, Albert TJ, Guttapalli A, Vresilovic EJ, Hillibrand AS, Vaccaro AR, Shapiro IM. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine. 29: 2627-32. PMID 15564911 DOI: 10.1097/01.Brs.0000146462.92171.7F |
0.301 |
|
2004 |
Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ. Stem cell regeneration of the nucleus pulposus. The Spine Journal : Official Journal of the North American Spine Society. 4: 348S-353S. PMID 15541688 DOI: 10.1016/J.Spinee.2004.07.031 |
0.33 |
|
2004 |
Toworfe GK, Composto RJ, Adams CS, Shapiro IM, Ducheyne P. Fibronectin adsorption on surface-activated poly(dimethylsiloxane) and its effect on cellular function. Journal of Biomedical Materials Research. Part A. 71: 449-61. PMID 15481053 DOI: 10.1002/Jbm.A.30164 |
0.57 |
|
2004 |
El-Ghannam AR, Ducheyne P, Risbud M, Adams CS, Shapiro IM, Castner D, Golledge S, Composto RJ. Model surfaces engineered with nanoscale roughness and RGD tripeptides promote osteoblast activity. Journal of Biomedical Materials Research. Part A. 68: 615-27. PMID 14986317 DOI: 10.1002/Jbm.A.20051 |
0.739 |
|
2004 |
Szymczyk KH, Shapiro IM, Adams CS. Ionizing radiation sensitizes bone cells to apoptosis. Bone. 34: 148-56. PMID 14751572 DOI: 10.1016/J.Bone.2003.09.003 |
0.376 |
|
2004 |
Martin N, Schaner P, Tulenko T, Shapiro I, Dimatteo C, Dimuzio P. Endothelial cell-seeding decellularized vein transplants: A novel arterial bypass conduit Journal of Surgical Research. 121: 303. DOI: 10.1016/J.Jss.2004.07.118 |
0.316 |
|
2003 |
Risbud MV, Izzo MW, Adams CS, Arnold WW, Hillibrand AS, Vresilovic EJ, Vaccaro AR, Albert TJ, Shapiro IM. An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells. Spine. 28: 2652-8; discussion 2. PMID 14673364 DOI: 10.1097/01.Brs.0000099384.58981.C6 |
0.303 |
|
2003 |
Mansfield K, Pucci B, Adams CS, Shapiro IM. Induction of apoptosis in skeletal tissues: phosphate-mediated chick chondrocyte apoptosis is calcium dependent. Calcified Tissue International. 73: 161-72. PMID 14565598 DOI: 10.1007/S00223-002-1056-Z |
0.33 |
|
2003 |
Adams CS, Shapiro IM. Mechanisms by which extracellular matrix components induce osteoblast apoptosis. Connective Tissue Research. 44: 230-9. PMID 12952203 DOI: 10.1080/03008200390181717 |
0.395 |
|
2003 |
Razzouk S, Shapiro IM. Detection of apoptotic gene expression in human osteoblast-like cells by cDNA microarrays Journal of Bone and Mineral Metabolism. 21: 261-267. PMID 12928826 DOI: 10.1007/S00774-003-0419-5 |
0.353 |
|
2003 |
Gan JC, Ducheyne P, Vresilovic EJ, Shapiro IM. Intervertebral disc tissue engineering II: cultures of nucleus pulposus cells. Clinical Orthopaedics and Related Research. 315-24. PMID 12782890 DOI: 10.1097/01.Blo.0000063797.98363.D3 |
0.602 |
|
2003 |
Gan JC, Ducheyne P, Vresilovic EJ, Swaim W, Shapiro IM. Intervertebral disc tissue engineering I: characterization of the nucleus pulposus. Clinical Orthopaedics and Related Research. 305-14. PMID 12782889 DOI: 10.1097/01.Blo.0000063796.98363.9A |
0.574 |
|
2003 |
Teixeira CC, Rajpurohit R, Mansfield K, Nemelivsky YV, Shapiro IM. Maturation-Dependent Thiol Loss Increases Chondrocyte Susceptibility to Apoptosis† Journal of Bone and Mineral Research. 18: 662-668. PMID 12674327 DOI: 10.1359/Jbmr.2003.18.4.662 |
0.347 |
|
2002 |
Adams CS, Shapiro IM. The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Critical Reviews in Oral Biology and Medicine : An Official Publication of the American Association of Oral Biologists. 13: 465-73. PMID 12499240 DOI: 10.1177/154411130201300604 |
0.409 |
|
2002 |
Cavalcanti-Adam EA, Shapiro IM, Composto RJ, Macarak EJ, Adams CS. RGD peptides immobilized on a mechanically deformable surface promote osteoblast differentiation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: 2130-40. PMID 12469907 DOI: 10.1359/Jbmr.2002.17.12.2130 |
0.392 |
|
2002 |
Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell and Tissue Research. 308: 401-7. PMID 12107433 DOI: 10.1007/S00441-002-0563-6 |
0.586 |
|
2002 |
Perlot RL, Shapiro IM, Mansfield K, Adams CS. Matrix regulation of skeletal cell apoptosis II: role of Arg-Gly-Asp-containing peptides. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: 66-76. PMID 11771671 DOI: 10.1359/Jbmr.2002.17.1.66 |
0.341 |
|
2001 |
Teixeira CC, Mansfield K, Hertkorn C, Ischiropoulos H, Shapiro IM. Phosphate-induced chondrocyte apoptosis is linked to nitric oxide generation American Journal of Physiology - Cell Physiology. 281. PMID 11502560 DOI: 10.1152/Ajpcell.2001.281.3.C833 |
0.3 |
|
2001 |
Adams CS, Mansfield K, Perlot RL, Shapiro IM. Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions. The Journal of Biological Chemistry. 276: 20316-22. PMID 11278303 DOI: 10.1074/Jbc.M006492200 |
0.327 |
|
2001 |
Mansfield K, Teixeira CC, Adams CS, Shapiro IM. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism. Bone. 28: 1-8. PMID 11165936 DOI: 10.1016/S8756-3282(00)00409-9 |
0.329 |
|
2001 |
Ducheyne P, El-Ghannam A, Shapiro IM, Composto RJ. Engineered RGD Peptide Surface Regulates Adhesion, Spreading and Cytoskeletal Organization of Osteoblast-Like Cells Key Engineering Materials. 245-248. DOI: 10.4028/Www.Scientific.Net/Kem.218-220.245 |
0.321 |
|
2000 |
Shenker BJ, Guo TL, Shapiro IM. Mercury-induced apoptosis in human lymphoid cells: Evidence that the apoptotic pathway is mercurial species dependent Environmental Research. 84: 89-99. PMID 11068922 DOI: 10.1006/Enrs.2000.4078 |
0.309 |
|
2000 |
Kaufmann EABE, Ducheyne P, Shapiro IM. Effect of varying physical properties of porous, surface modified bioactive glass 45S5 on osteoblast proliferation and maturation Journal of Biomedical Materials Research. 52: 783-796. PMID 11033562 DOI: 10.1002/1097-4636(20001215)52:4<783::Aid-Jbm24>3.0.Co;2-J |
0.633 |
|
2000 |
Meleti Z, Shapiro IM, Adams CS. Inorganic phosphate induces apoptosis of osteoblast-like cells in culture. Bone. 27: 359-66. PMID 10962346 DOI: 10.1016/S8756-3282(00)00346-X |
0.404 |
|
2000 |
Kaufmann EABE, Ducheyne P, Shapiro IM. Evaluation of osteoblast response to porous bioactive glass (45S5) substrates by RT-PCR analysis Tissue Engineering. 6: 19-28. PMID 10941197 DOI: 10.1089/107632700320856 |
0.628 |
|
2000 |
Gan JC, Ducheyne P, Vresilovic E, Shapiro IM. Bioactive glass serves as a substrate for maintenance of phenotype of nucleus pulposus cells of the intervertebral disc. Journal of Biomedical Materials Research. 51: 596-604. PMID 10880107 DOI: 10.1002/1097-4636(20000915)51:4<596::Aid-Jbm7>3.0.Co;2-O |
0.613 |
|
1999 |
Yagami K, Suh J, Enomoto-Iwamoto M, Koyama E, Abrams WR, Shapiro IM, Pacifici M, Iwamoto M. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. Journal of Cell Biology. 147: 1097-1108. PMID 10579728 DOI: 10.1083/Jcb.147.5.1097 |
0.405 |
|
1999 |
Shapiro IM. Discovery: Osf2/Cbfa1, a master gene of bone formation Clinical Orthodontics and Research. 2: 42-46. PMID 10534978 DOI: 10.1111/Ocr.1999.2.1.42 |
0.367 |
|
1999 |
El-Ghannam A, Ducheyne P, Shapiro IM. Effect of serum proteins on osteoblast adhesion to surface-modified bioactive glass and hydroxyapatite Journal of Orthopaedic Research. 17: 340-345. PMID 10376721 DOI: 10.2106/00004623-199910000-00026 |
0.735 |
|
1999 |
Hobson GM, Funanage VL, Elsemore J, Yagami M, Rajpurohit R, Perriard JC, Hickok NJ, Shapiro IM, Tuan RS. Developmental expression of creatine kinase isoenzymes in chicken growth cartilage. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 14: 747-56. PMID 10320523 DOI: 10.1359/Jbmr.1999.14.5.747 |
0.334 |
|
1999 |
Rajpurohit R, Mansfield K, Ohyama K, Ewert D, Shapiro IM. Chondrocyte death is linked to development of a mitochondrial membrane permeability transition in the growth plate. Journal of Cellular Physiology. 179: 287-296. PMID 10228947 DOI: 10.1002/(Sici)1097-4652(199906)179:3<287::Aid-Jcp6>3.0.Co;2-T |
0.36 |
|
1999 |
Mansfield K, Rajpurohit R, Shapiro IM. Extracellular phosphate lions cause apoptosis of terminally differentiated epiphyseal chondrocytes Journal of Cellular Physiology. 179: 276-286. PMID 10228946 DOI: 10.1002/(Sici)1097-4652(199906)179:3<276::Aid-Jcp5>3.0.Co;2-# |
0.364 |
|
1998 |
Guo TL, Miller MA, Shapiro IM, Shenker BJ. Mercuric chloride induces apoptosis in human T lymphocytes: Evidence of mitochondrial dysfunction Toxicology and Applied Pharmacology. 153: 250-257. PMID 9878595 DOI: 10.1006/Taap.1998.8549 |
0.321 |
|
1998 |
Guo TL, Miller MA, Datar S, Shapiro IM, Shenker BJ. Inhibition of poly(ADP-ribose) polymerase rescues human T lymphocytes from methylmercury-induced apoptosis. Toxicology and Applied Pharmacology. 152: 397-405. PMID 9853008 DOI: 10.1006/Taap.1998.8526 |
0.324 |
|
1998 |
Santos EM, Radin S, Shenker BJ, Shapiro IM, Ducheyne P. Si-Ca-P xerogels and bone morphogenetic protein act synergistically on rat stromal marrow cell differentiation in vitro Journal of Biomedical Materials Research. 41: 87-94. PMID 9641628 DOI: 10.1002/(Sici)1097-4636(199807)41:1<87::Aid-Jbm11>3.0.Co;2-E |
0.632 |
|
1998 |
Shenker BJ, Guo TL, Shapiro IM. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction Environmental Research. 77: 149-159. PMID 9600808 DOI: 10.1006/Enrs.1997.3816 |
0.321 |
|
1997 |
Insug O, Datar S, Koch CJ, Shapiro IM, Shenker BJ. Mercuric compounds inhibit human monocyte function by inducing apoptosis: Evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve Toxicology. 124: 211-224. PMID 9482123 DOI: 10.1016/S0300-483X(97)00153-4 |
0.329 |
|
1997 |
Ohyama K, Farquharson C, Whitehead CC, Shapiro IM. Further observations on programmed cell death in the epiphyseal growth plate: Comparison of normal and dyschondroplastic epiphyses Journal of Bone and Mineral Research. 12: 1647-1656. PMID 9333125 DOI: 10.1359/Jbmr.1997.12.10.1647 |
0.359 |
|
1997 |
El-Ghannam A, Ducheyne P, Shapiro IM. Porous bioactive glass and hydroxyapatite ceramic affect bone cell function in vitro along different time lines Journal of Biomedical Materials Research. 36: 167-180. PMID 9261678 DOI: 10.1002/(Sici)1097-4636(199708)36:2<167::Aid-Jbm5>3.0.Co;2-I |
0.765 |
|
1997 |
Kirsch T, Nah HD, Shapiro IM, Pacifici M. Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes Journal of Cell Biology. 137: 1149-1160. PMID 9166414 DOI: 10.1083/Jcb.137.5.1149 |
0.354 |
|
1997 |
Shenker BJ, Datar S, Mansfield K, Shapiro IM. Induction of apoptosis in human T-cells by organomercuric compounds: A flow cytometric analysis Toxicology and Applied Pharmacology. 143: 397-406. PMID 9144456 DOI: 10.1006/Taap.1997.8111 |
0.335 |
|
1997 |
Shapiro IM, Mansfield KD, Evans SM, Lord EM, Koch CJ. Chondrocytes in the endochondral growth cartilage are not hypoxic American Journal of Physiology - Cell Physiology. 272. PMID 9142837 DOI: 10.1152/Ajpcell.1997.272.4.C1134 |
0.327 |
|
1997 |
El-Ghannam A, Ducheyne P, Shapiro IM. Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix Biomaterials. 18: 295-303. PMID 9068890 DOI: 10.1016/S0142-9612(96)00059-2 |
0.755 |
|
1997 |
Ducheyne P, Livingston T, Shapiro I, Ayyaswamy P, Gao H, Radin S. Surface-modified bioactive glass particles as microcarriers in a microgravity environment Tissue Engineering. 3: 219-229. DOI: 10.1089/Ten.1997.3.219 |
0.619 |
|
1996 |
Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM. Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. Journal of Cellular Physiology. 168: 424-32. PMID 8707878 DOI: 10.1002/(Sici)1097-4652(199608)168:2<424::Aid-Jcp21>3.0.Co;2-1 |
0.61 |
|
1996 |
Teixeira CC, Shapiro IM, Hatori M, Rajpurohit R, Koch C. Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes. Biochemical Journal. 314: 21-26. PMID 8660285 DOI: 10.1042/Bj3140021 |
0.341 |
|
1996 |
El-Ghannam A, Ducheyne P, Shapiro IM. Effect of serum protein adsorption on osteoblast adhesion to bioactive glass and hydroxyapatite Transactions of the Annual Meeting of the Society For Biomaterials in Conjunction With the International Biomaterials Symposium. 2: 418. |
0.653 |
|
1996 |
El-Ghannam A, Ducheyne P, Shapiro IM. Porous bioactive glass and hydroxyapatite affect bone cell function in vitro along different time lines Transactions of the Annual Meeting of the Society For Biomaterials in Conjunction With the International Biomaterials Symposium. 2: 665. |
0.648 |
|
1995 |
Hatori M, Klatte KJ, Teixeira CC, Shapiro IM. End labeling studies of fragmented DNA in the avian growth plate: Evidence of apoptosis in terminally differentiated chondrocytes Journal of Bone and Mineral Research. 10: 1960-1968. PMID 8619377 DOI: 10.1002/Jbmr.5650101216 |
0.338 |
|
1995 |
Hatori M, Sparkman J, Teixeira CC, Grynpas M, Nervina J, Olivieri N, Shapiro IM. Effects of deferoximine on chondrocyte alkaline phosphatase activity: Proxidant role of deferoximine in thalassemia Calcified Tissue International. 57: 229-236. PMID 8574942 DOI: 10.1007/Bf00310264 |
0.336 |
|
1995 |
El-Ghannam A, Ducheyne P, Shapiro IM. Bioactive material template for in vitro synthesis of bone Journal of Biomedical Materials Research. 29: 359-370. PMID 7615587 DOI: 10.1002/Jbm.820290311 |
0.758 |
|
1995 |
Harrison G, Shapiro IM, Golub EE. The phosphatidylinositol-glycolipid anchor on alkaline phosphatase facilitates mineralization initiation in vitro Journal of Bone and Mineral Research. 10: 568-573. PMID 7610927 DOI: 10.1002/Jbmr.5650100409 |
0.358 |
|
1995 |
Hatori M, Teixeira CC, Debolt K, Pacifici M, Shapiro IM. Adenine nucleotide metabolism by chondrocytes in vitro: Role of ATP in chondrocyte maturation and matrix mineralization Journal of Cellular Physiology. 165: 468-474. PMID 7593225 DOI: 10.1002/Jcp.1041650304 |
0.365 |
|
1995 |
Teixeira CC, Hatori M, Leboy PS, Pacifici M, Shapiro IM. A rapid and ultrasensitive method for measurement of DNA, calcium and protein content, and alkaline phosphatase activity of chondrocyte cultures Calcified Tissue International. 56: 252-256. PMID 7538446 DOI: 10.1007/Bf00298620 |
0.332 |
|
1994 |
Shapiro IM, Debolt K, Hatori M, Iwamoto M, Pacifici M. Retinoic acid induces a shift in the energetic state of hypertrophic chondrocytes Journal of Bone and Mineral Research. 9: 1229-1237. PMID 7976505 DOI: 10.1002/Jbmr.5650090813 |
0.329 |
|
1994 |
Iwamoto M, Yagami K, Shapiro IM, Leboy PS, Adams SL, Pacifici M. Retinoic acid is a major regulator of chondrocyte maturation and matrix mineralization. Microscopy Research and Technique. 28: 483-91. PMID 7949394 DOI: 10.1002/Jemt.1070280604 |
0.381 |
|
1994 |
Ducheyne P, El-Ghannam A, Shapiro I. Effect of bioactive glass templates on osteoblast proliferation and in vitro synthesis of bone-like tissue Journal of Cellular Biochemistry. 56: 162-167. PMID 7829574 DOI: 10.1002/Jcb.240560207 |
0.749 |
|
1994 |
El-Ghannam A, Ducheyne P, Shapiro IM. Bioactive glass templates for the synthesis of bone like tissue in vitro Materials Research Society Symposium Proceedings. 331: 257-262. DOI: 10.1557/Proc-331-257 |
0.752 |
|
1993 |
Iwamoto M, Shapiro IM, Yagami K, Boskey AL, Leboy PS, Adams SL, Pacifici M. Retinoic acid induces rapid mineralization and expression of mineralization-related genes in chondrocytes. Experimental Cell Research. 207: 413-20. PMID 8344389 DOI: 10.1006/Excr.1993.1209 |
0.327 |
|
1992 |
Shapiro IM, Debolt K, Funanage VL, Smith SM, Tuan RS. Developmental regulation of creatine kinase activity in cells of the epiphyseal growth cartilage. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 7: 493-500. PMID 1615758 DOI: 10.1002/Jbmr.5650070505 |
0.353 |
|
1992 |
Golub EE, Harrison G, Taylor AG, Camper S, Shapiro IM. The role of alkaline phosphatase in cartilage mineralization Bone and Mineral. 17: 273-278. PMID 1611320 DOI: 10.1016/0169-6009(92)90750-8 |
0.306 |
|
1992 |
Funanage VL, Carango P, Shapiro IM, Tokuoka T, Tuan RS. Creatine kinase activity is required for mineral deposition and matrix synthesis in endochondral growth cartilage. Bone and Mineral. 17: 228-36. PMID 1611312 DOI: 10.1016/0169-6009(92)90742-V |
0.355 |
|
1992 |
Chung C, Golub EE, Forbes E, Tokuoka T, Shapiro IM. Mechanism of action of β-glycerophosphate on bone cell mineralization Calcified Tissue International. 51: 305-311. PMID 1422975 DOI: 10.1007/Bf00334492 |
0.35 |
|
1991 |
Pacifici M, Golden EB, Adams SL, Shapiro IM. Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytes. Experimental Cell Research. 192: 266-70. PMID 1984417 DOI: 10.1016/0014-4827(91)90185-W |
0.354 |
|
1991 |
Shapiro IM, Leboy PS, Tokuoka T, Forbes E, DeBolt K, Adams SL, Pacifici M. Ascorbic acid regulates multiple metabolic activities of cartilage cells. The American Journal of Clinical Nutrition. 54: 1209S-1213S. PMID 1962572 DOI: 10.1093/Ajcn/54.6.1209S |
0.387 |
|
1991 |
Matsumoto H, Silverton SF, Debolt K, Shapiro IM. Superoxide dismutase and catalase activities in the growth cartilage: Relationship between oxidoreductase activity and chondrocyte maturation Journal of Bone and Mineral Research. 6: 569-574. PMID 1887819 DOI: 10.1002/Jbmr.5650060607 |
0.312 |
|
1990 |
Pacifici M, Oshima O, Fisher LW, Young MF, Shapiro IM, Leboy PS. Changes in osteonectin distribution and levels are associated with mineralization of the chicken tibial growth cartilage. Calcified Tissue International. 47: 51-61. PMID 2369692 DOI: 10.1007/Bf02555866 |
0.36 |
|
1990 |
Pacifici M, Golden EB, Oshima O, Shapiro IM, Leboy PS, Adams SL. Hypertrophic chondrocytes. The terminal stage of differentiation in the chondrogenic cell lineage? Annals of the New York Academy of Sciences. 599: 45-57. PMID 2221676 DOI: 10.1111/J.1749-6632.1990.Tb42363.X |
0.374 |
|
1989 |
Oshima O, Leboy PS, McDonald SA, Tuan RS, Shapiro IM. Developmental expression of genes in chick growth cartilage detected by in situ hybridization Calcified Tissue International. 45: 182-192. PMID 2505910 DOI: 10.1007/Bf02556062 |
0.301 |
|
1988 |
Shapiro IM, Golub EE, Chance B, Piddington C, Oshima O, Tuncay OC, Frasca P, Haselgrove JC. Linkage between energy status of perivascular cells and mineralization of the chick growth cartilage. Developmental Biology. 129: 372-9. PMID 3417044 DOI: 10.1016/0012-1606(88)90384-3 |
0.338 |
|
1986 |
Kakuta S, Golub EE, Haselgrove JC, Chance B, Frasca P, Shapiro IM. Redox studies of the epiphyseal growth cartilage: pyridine nucleotide metabolism and the development of mineralization. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 1: 433-40. PMID 3503558 DOI: 10.1002/Jbmr.5650010508 |
0.332 |
|
1986 |
Minkin C, Shapiro IM. Osteoclasts, mononuclear phagocytes, and physiological bone resorption Calcified Tissue International. 39: 357-359. PMID 3099999 DOI: 10.1007/Bf02555171 |
0.364 |
|
1985 |
Kakuta S, Golub EE, Shapiro IM. Morphochemical analysis of phosphorus pools in calcifying cartilage Calcified Tissue International. 37: 293-299. PMID 3926279 DOI: 10.1007/Bf02554877 |
0.312 |
|
1984 |
Shapiro IM, Boyde A. Microdissection-elemental analysis of the mineralizing growth cartilage of the normal and rachitic chick Metabolic Bone Disease and Related Research. 5: 317-326. PMID 6493043 DOI: 10.1016/0221-8747(84)90019-5 |
0.349 |
|
1982 |
Shapiro IM, Golub EE, Kakuta S, Hazelgrove J, Havery J, Chance B, Frasca P. Initiation of endochondral calcification is related to changes in the redox state of hypertrophic chondrocytes. Science (New York, N.Y.). 217: 950-2. PMID 7112108 DOI: 10.1126/Science.7112108 |
0.327 |
|
1975 |
Shanfeld J, Shapiro I, Davidovitch Z. The measurement of adenosine 3,5-monophosphate in bone. Analytical Biochemistry. 66: 450-9. PMID 166572 DOI: 10.1016/0003-2697(75)90613-2 |
0.336 |
|
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